CN103285255B - Anti-coccidiosis pharmaceutical composition as well as preparation method and use thereof - Google Patents
Anti-coccidiosis pharmaceutical composition as well as preparation method and use thereof Download PDFInfo
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Abstract
The invention relates to the field of veterinary drugs, in particular to prevention and cure of coccidiosis in chicken, precisely an anti-coccidiosis pharmaceutical composition and a preparation method thereof. The pharmaceutical composition disclosed by the invention is a Chinese herbal medicine preparation prepared by taking gemma agrimoninae, artemisia apiacea, coptis chinensis, elecampane, scutellaria baicalensis, antifebrile dichroa, clinopodium polycephalum, pinellia ternata, caulis bambusae in taeniam and the root of kudzu vine as crude drugs. The pharmaceutical composition disclosed by the invention has an obvious effect on treating avian coccidiosis; simultaneously, the pharmaceutical composition has the advantages of being safe for use, free from residue, difficult for generating drug resistance, low in cost and the like.
Description
Technical field
The present invention relates to field of veterinary, particularly the control of chicken coccidiosis, is specifically disclose a kind of coccidiostat combination and preparation method thereof.
Background technology
Chicken coccidiosis is the chicken parasitic disease caused by Eimeria, is to endanger maximum a kind of parasitic disease to poultry husbandry at present.This pathogen not only life cycle long, resistance is strong, and general disinfecting drug is difficult to be killed, and ill chicken still may excrete with pathogen in several months after being ill, thus pollutes cycle stretch-out.This disease is multiple is in the past born in spring and autumn joint, and the infection scope of coccidiosis also develops into into chicken by chickling gradually and plants chicken.Chicken coccidiosis infects into chicken, the growth promoter of Growing Chicken can be caused although most to be obstructed in recessive symptom, and all can cause corresponding impact to the rate of fertilization etc. of the survival rate of kind of chicken, laying rate and hatching egg.
The means of current control chicken coccidiosis are still based on chemoprophylaxis, and the economic loss that the whole world causes because of chicken coccidiosis is every year more than 2,000,000,000 dollars.Poultry husbandry occupies very large proportion in China's animal husbandry, especially in middle part and the southern areas of China, because warmer climate is moist, is more conducive to existence and the propagation of coccidian oocyst, more serious to the harm of poultry husbandry.At present, the protective agents of coccidiosis of domestic fowls comprises polyether ionophoric antibiotics and chemosynthesis coccidiostat.Coccidiosis, easily to anticoccidial drug resistant, makes the selectable active drug of control coccidiosis fewer and feweri.In recent years, the coccidial vaccine that the chicken that market has occurred is special, but there is preventive effect instability, and the danger breaking out chicken coccidiosis after having use, may be there is.Therefore, the generation from thorough prevention and control coccidiosis also acquires a certain degree of difficulty, and the control of coccidiosis is further difficult.
But Chinese herbal medicine has the advantages such as toxic and side effects is little, worm is killed in noresidue, enhancing human body immunity function, not easily generation drug resistance because of it, and is subject to the favor of vast breeding enterprise.Improving constantly along with the domestic and international attention degree to food safety, in the urgent need to efficient, toxic and side effects is little, the medicine of noresidue, solve abuse of antibiotics, chemical synthetic drug to bring in animal derived food residual, drug resistance, toxic and side effects problem.The Chinese herbal medicine resource of China's abundant, under the guidance of modern medicine theory, the modern Chinese veterinary drug preparation of application Chinese veterinarian traditional theory exploitation anticoccidial has great importance and wide application prospect.
Summary of the invention
The object of the present invention is to provide a kind of effectively Anticoccidiosis pharmaceutical composition, especially for the pharmaceutical composition for the treatment of coccidiosis of domestic fowls.
Another object of the present invention is to provide preparation method and the purposes of this pharmaceutical composition.
The invention provides a kind of Anticoccidiosis pharmaceutical composition, it is characterized in that: it is the preparation be prepared from by the ingredient of following weight proportioning:
Bud of hairyvein agrimony 10-25 part, Herba Artemisiae Annuae 15-25 part, Rhizoma Coptidis 5-15 part, Radix Aucklandiae 5-15 part, Radix Scutellariae 5-15 part, Radix Dichroae 15-20 part, Herba Clinopodii 5-25 part, Rhizoma Pinelliae 5-15 part, Caulis Bambusae In Taenia 5-15 part, Radix Puerariae 5-15 part.
Further, the weight proportion of said medicine composition is as follows:
Bud of hairyvein agrimony 10-25 part, Herba Artemisiae Annuae 15-25 part, Rhizoma Coptidis 5-15 part, Radix Aucklandiae 5-15 part, Radix Scutellariae 5-15 part, Radix Dichroae 15-20 part, Herba Clinopodii 5-25 part, Rhizoma Pinelliae 5-15 part, Caulis Bambusae In Taenia 5-15 part, Radix Puerariae 5-15 part.
Further, the weight proportion of said medicine composition is as follows:
Bud of hairyvein agrimony 20 parts, Herba Artemisiae Annuae 20 parts, Rhizoma Coptidis 10 parts, the Radix Aucklandiae 10 parts, Radix Scutellariae 10 parts, Radix Dichroae 20 parts, Herba Clinopodii 10 parts, the Rhizoma Pinelliae 10 parts, Caulis Bambusae In Taenia 10 parts, Radix Puerariae 10 parts.
Present invention also offers the preparation method of this Anticoccidiosis pharmaceutical composition, it comprises the steps:
(1) each ingredient is taken by weight ratio.
(2) each medicine material taken is pulverized, sieve after maybe by each medicine material of taking through water or alcohol extraction, concentrated after, then add adjuvant conventional in pharmacy or complementary composition, be prepared from.
The dosage form of the Anticoccidiosis pharmaceutical composition that the preparation method of Anticoccidiosis pharmaceutical composition of the present invention obtains is:
Powder, powder, granule or oral liquid.
Anticoccidiosis pharmaceutical composition of the present invention can be used for preparation treatment coccidiostat.
Anticoccidiosis pharmaceutical composition of the present invention more can be used for preparation treatment poultry against coccidia medicine.
Each drug component in pharmaceutical composition of the present invention and consumption thereof are according to Chinese veterinarian's prescription dialectical treatmert principle, get by repeatedly practise in a large number, there is heat-clearing and toxic substances removing, parasite killing goes to amass, the function of astringing to arrest bleeding, after being prepared into pharmaceutically conventional preparation, cure mainly the application of fowl coccidiosis disease aspect.
Advantage and the good effect of medicine of the present invention are:
(1) medicine of the present invention plays Chinese medicine organic conception and dialectically treats theory, good effect, instant effect, treating both the principal and secondary aspects of a disease, can be used for preventing and treating chicken coccidiosis.
(2) medicine of the present invention is pure Chinese medicinal preparation, and toxic and side effects is little, noresidue, can not produce harm, not easily produce drug resistance, free from environmental pollution the health of the mankind;
(3) medicine of the present invention can be absorbed fast and be played due drug effect in animal body, the modes such as mixed drink, mixed feeding can be adopted simultaneously to concentrate administration, be beneficial to mass prevention and mass treatment;
(4) medicine material wide material sources of the present invention, production technology is simple, and production cost is low, has saved the spending of poultry medication widely.
Detailed description of the invention
Embodiment 1 medicine preparation of the present invention and use
Take the raw material containing following weight:
Bud of hairyvein agrimony 20g, Herba Artemisiae Annuae 20g, Rhizoma Coptidis 10g, Radix Aucklandiae 10g, Radix Scutellariae 10g, Radix Dichroae 20g, Herba Clinopodii 10g, Rhizoma Pinelliae 10g, Caulis Bambusae In Taenia 10g, Radix Puerariae 10g.
(2), after being pulverized by each weight crude drug claimed in step (1), sieving, fully powder is mixed with into.Drug use method of the present invention: coccidiosis, mixed feeding: every 1kg feedstuff, fowl 10g, is used in conjunction 7.
Embodiment 2 medicine preparation of the present invention and use
(1) raw material containing following weight is taken:
Bud of hairyvein agrimony 10g, Herba Artemisiae Annuae 10g, Rhizoma Coptidis 5g, Radix Aucklandiae 5g, Radix Scutellariae 5g, Radix Dichroae 10g, Herba Clinopodii 5g, Rhizoma Pinelliae 5g, Caulis Bambusae In Taenia 5g, Radix Puerariae 5g.
(2) after each weight proportion crude drug claimed in step (1) being pulverized, after first medical material being soaked 2 hours with ethanol, alcohol reflux 2 times, each 2 hours, merging filtrate was also condensed into paste; Filtering residue uses water extraction 2 times again, each 2 hours at every turn, and filter, merging filtrate is also condensed into paste; Merge extractum, finally add appropriate amount of starch and dextrin (or other adjuvant), mix homogeneously, makes soft material, granulates, and dries, is namely prepared into granule (every 1g is equivalent to crude drug in whole 2g).
(3) drug use method of the present invention: coccidiosis, mixed drink: fowl, every 1L water adds this product 2.5g, freely drinks, and is used in conjunction 7.
Embodiment 3 medicine preparation of the present invention and use
(1) raw material containing following weight is taken:
Bud of hairyvein agrimony 20 parts, Herba Artemisiae Annuae 20 parts, Rhizoma Coptidis 10 parts, the Radix Aucklandiae 10 parts, Radix Scutellariae 10 parts, Radix Dichroae 20 parts, Herba Clinopodii 10 parts, the Rhizoma Pinelliae 10 parts, Caulis Bambusae In Taenia 10 parts, Radix Puerariae 10 parts.
(2) after each weight proportion crude drug claimed in step (1) being pulverized, after first medical material being soaked 2 hours with ethanol, alcohol reflux 2 times, each 2 hours, merging filtrate was also condensed into paste; Filtering residue uses water extraction 2 times again, each 2 hours at every turn, and filter, merging filtrate is also condensed into paste; Merge extractum, finally add appropriate amount of starch and dextrin (or other adjuvant), mix homogeneously, dry, pulverize, be namely prepared into powder (every 1g is equivalent to crude drug in whole 1g).
(3) drug use method of the present invention: coccidiosis, mixed feeding: poultry, fowl, every 1kg feedstuff adds medicine 5g of the present invention, is used in conjunction 7.
Embodiment 4 medicine preparation of the present invention and use
(1) raw material containing following weight is taken:
Bud of hairyvein agrimony 20g, Herba Artemisiae Annuae 20g, Rhizoma Coptidis 10g, Radix Aucklandiae 10g, Radix Scutellariae 10g, Radix Dichroae 20g, Herba Clinopodii 10g, Rhizoma Pinelliae 10g, Caulis Bambusae In Taenia 10g, Radix Puerariae 10g.
(2) after being pulverized by each weight proportion crude drug claimed in step (1), after medical material being soaked 1 hour with water, then decoct to boiling with high heat, then use slow fire boiling 30 minutes, filter, filtering residue adds water with slow fire boiling twice, each 1 hour.Merging filtrate, is concentrated into 130 milliliters by filtrate, adding ethanol content in ethanol to filtrate is 70%, and filter, filtrate recycling ethanol, is concentrated into every 1ml and is equivalent to crude drug in whole 1g, and filter, embedding, sterilizing, is namely prepared into oral liquid.
(3) drug use method of the present invention: coccidiosis, mixed drink: fowl, every 1L water adds this product 5ml, freely drinks, and is used in conjunction 7.
For showing the prevention effect of medicine of the present invention to coccidiosis, clinical observation on the therapeutic effect test being carried out to medicine of the present invention, sets forth the beneficial effect of medicine of the present invention below by way of test example further.
Test example 1
Place: chicken farm, Anqing Wangjiang
In May, 2011, spirit is depressed, feather is fluffy, it is slow-witted vertical to close one's eyes to have the chicken of nearly 1/3 to occur in Yuan plant about 2000 plumage 23 age in days miscellaneous chicken, and feed intake declines, the phenomenons such as amount of drinking water increase.Sick chicken arranges white loose stool or watery stools, and severe one discharges red hemafecia, is full of mucus in the feces that part chicken is discharged.Cut open the sick chicken of inspection and find that intestinal wall outward appearance has bolarious ecchymosis, caecum, small intestinal are in hemorrhagic inflammation in various degree, and intestinal mucosa thickens, and has ecchymosis or necrosis region, is diagnosed as chicken coccidiosis.After being picked out from Ji Qunzhong by ill for institute chicken, use embodiment 1 to prepare medicine of the present invention, adopt mixed feeding administration, every 1 ton of feedstuff adds medicine 10kg of the present invention, is used in conjunction 7.From the 3rd day, the state of an illness started to alleviate, and within the 5th day, plays institute's ill chicken spirit state, appetite recovery is normal.
Test example 2
Place: Anhui Huaao Biotechnology Co., Ltd.'s veterinary drug research and development centre experimental animal room
Get healthy 20 Japanese instar chickling 120, be divided into 4 groups at random, be respectively blank group, infect matched group, medicine group of the present invention and sulfaclozine group.Blank group is not fallen ill not administration, and infect matched group and to fall ill not administration, medicine group of the present invention uses embodiment 2 to prepare, and add in drinking water according to 2.5g/L dosage, sulfaclozine sodium adds in feedstuff according to 600mg/kg.Except blank group, all the other 2 groups in administration after 24 hours, according to 1 × 10
4an individual/coccidian oocyst is inoculated.Observe test, after one week, slaughter the test chicken of survival, record correlation test data, result of the test sees the following form.
Note: anticoccidial index (Anticoccidial index, ACI), ACI=(survival rate+body weight increase rate) × 100-(pathological changes value+egg capsule value), ACI are greater than 180 for efficient anticoccidial drug.
This result of the test shows, medicine of the present invention infects chicken coccidiosis significant therapeutic effect, and medicine group curative effect of the present invention is better than sulfaclozine sodium pre-mixing agent, and by the method for drinking water administration, simple and easy to do.Department of Pharmacy of the present invention pure natural medical, not easily produces drug resistance, compared with chemicals, has obvious advantage.
Test example 3
Place: chicken farm, Feixi, Hefei ,Anhui
In June, 2011, Feixi, Hefei City, Anhui Province small towns Liu family raises table hens 3000, and early growth is good, and 24 ages in days start morbidity and constantly death.Sick chicken off color, disorderly, eye semi-closure, loss of appetite, necking down is slow-witted vertical, and ataxia draining sample redness just for feather pine.Cut open inspection sick chicken duodenum, jejunum outward appearance be aubergine and have the petechia differed in size, caecum swells, and is mixed with blood and cheesy thing, and intestinal wall has transparent round speckle, is diagnosed as chickens infected with eimeria.Use embodiment 4 to prepare medicine of the present invention, the administration of mixed drink, freely drinks, after being used in conjunction 7, and the rehabilitation gradually of sick chicken.
Although the present invention describes with reference to specific embodiment, this description not meaning that is construed as limiting the present invention.With reference to description of the invention, other distortion of the disclosed embodiments, all can expect for those skilled in the art.Therefore, such distortion can not depart from scope and the spirit of appended claims restriction.
Claims (5)
1. an anticoccidial drugs compositions, is characterized in that: it is the preparation be prepared from by the ingredient of following weight proportioning:
Bud of hairyvein agrimony 10-25 part, Herba Artemisiae Annuae 15-25 part, Rhizoma Coptidis 5-15 part, Radix Aucklandiae 5-15 part, Radix Scutellariae 5-15 part, Radix Dichroae 15-20 part, Herba Clinopodii 5-15 part, Rhizoma Pinelliae 5-15 part, Caulis Bambusae In Taenia 5-15 part, Radix Puerariae 5-15 part.
2. anticoccidial drugs compositions according to claim 1, is characterised in that: it is the preparation be prepared from by the ingredient of following weight proportioning:
Bud of hairyvein agrimony 20 parts, Herba Artemisiae Annuae 20 parts, Rhizoma Coptidis 10 parts, the Radix Aucklandiae 10 parts, Radix Scutellariae 10 parts, Radix Dichroae 20 parts, Herba Clinopodii 10 parts, the Rhizoma Pinelliae 10 parts, Caulis Bambusae In Taenia 10 parts, Radix Puerariae 10 parts.
3. a preparation method for anticoccidial drugs compositions as claimed in claim 1 or 2, it comprises the steps:
(1) by weight ratio, each ingredient is taken,
(2) each medicine material taken is pulverized, sieve after maybe by each medicine material of claiming through water or alcohol extraction, concentrated after, then add adjuvant conventional in pharmacy, be prepared from.
4. the preparation method of anticoccidial drugs compositions according to claim 3, is characterized in that the dosage form obtained is: powder, tablet, granule, oral liquid or injection.
5. the anticoccidial drugs compositions described in claim 1 or 2 is in the application preparing anticoccidial drugs object space face.
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| CN104337967A (en) * | 2014-10-21 | 2015-02-11 | 郑州后羿制药有限公司 | Traditional Chinese medicine composition for treating coccidiosis in chicken and preparation method of traditional Chinese medicine composition |
| CN106389741A (en) * | 2016-09-30 | 2017-02-15 | 安徽华澳生物技术有限公司 | Medicament for preventing and treating chicken coccidiosis |
| CN107279535B (en) * | 2017-07-12 | 2019-01-04 | 江苏隆达生物科技有限公司 | A kind of feed addictive and production method for newborn piglet expelling parasite |
| CN108815222A (en) * | 2018-09-13 | 2018-11-16 | 四川农业大学 | A kind of preparation method and application of anticoccidial Chinese medicine composition |
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| CN101670005B (en) * | 2009-09-29 | 2011-11-23 | 北京大北农动物保健科技有限责任公司 | Anticoccidiosis pharmaceutical composition and preparation method and use thereof |
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Addressee: Patent manager of Anhui Agriculture University Document name: Notification that Application Deemed not to be Proposed |
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Denomination of invention: A combination of anti coccidiosis drugs and its preparation method and application Effective date of registration: 20240102 Granted publication date: 20141224 Pledgee: Anhui Changfeng rural commercial bank Limited by Share Ltd. double pier branch Pledgor: ANHUI HUAAO BIOTECHNOLOGY Pty Ltd. Registration number: Y2023980075844 |