CN104337967A - Traditional Chinese medicine composition for treating coccidiosis in chicken and preparation method of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition for treating coccidiosis in chicken and preparation method of traditional Chinese medicine composition Download PDFInfo
- Publication number
- CN104337967A CN104337967A CN201410559909.0A CN201410559909A CN104337967A CN 104337967 A CN104337967 A CN 104337967A CN 201410559909 A CN201410559909 A CN 201410559909A CN 104337967 A CN104337967 A CN 104337967A
- Authority
- CN
- China
- Prior art keywords
- parts
- chicken
- chinese medicine
- radix
- medicine composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/285—Aucklandia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
Abstract
The invention relates to a traditional Chinese medicine composition for treating coccidiosis in chicken. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 12-18 parts of radix dichroa, 9-21 parts of herba agrimoniae, 6-9 parts of fructus bruceae, 15-36 parts of artemisia apiacea, 9-21 parts of paeonia lactiflora, 6-12 parts of angelica, 6-15 parts of rhizoma coptidis, 6-12 parts of areca catechu, 6-12 parts of radix aucklandiae, 9-15 parts of rheum officinale, 9-18 parts of radix scutellariae and 6-12 parts of cinnamomum cassia. Compared with the prior art, the traditional Chinese medicine composition is prepared from pure natural Chinese herbal medicines, raw medicines are easily available, and the traditional Chinese medicine composition is cheap, safe and has no residue and no any toxic and side effects to bodies of beasts and birds. The traditional Chinese medicine composition is prepared into powder, and a preparation method is simple, easy to operate and suitable for large-scale production application.
Description
Technical field
The invention belongs to technical field of Chinese medicine for animals, be specifically related to a kind of Chinese medicine composition being used for the treatment of chicken coccidiosis and preparation method thereof.
Background technology
Chicken coccidiosis (Coccidiosis in Chicken) colonizes in chicken intestinal mucomembranous epithelial cell by one or more coccidiosiss the acute popular protozoacide caused, it is the common and very serious a kind of parasitic disease of harm of chicken, all likely occur throughout the year, especially the most serious with hot and humid weather, the chickling incidence rate of sickness rate 15 ~ 50 age in days is up to 100%, and mortality rate can reach more than 80%.The chick growth of resistance to mistake is slow, dysplasia.Become chicken mostly be carrier, healthy chicken eaten coccidiosis chicken manure pollute feedstuff, drinking-water the most easily infected.Destroy enterocyte when coccidiosis grows in vivo and cause digestion, malabsorption, chick growth is slow, and dysplasia, causes the growth retardation of chicken, even dead etc., brings massive losses to animal husbandry.
Applying now more is clinically polyethers chemicals, but prevent this disease from needing continual medication, chicken long-term taking chemicals of catching an illness can cause drug residue, very easily produce drug resistance again, have a strong impact on therapeutic effect, reduce the meat of chicken, the quality of egg product and safety, increasing to chicken body, meat, egg and sanitarian harm.Since the forties in last century, Levine found that sulfa drugs has Anti-human globulin test, successively have 50 multi-medicaments to drop into clinical practice, contribution has been made in the development for poultry husbandry.But along with the extensive use of medicine, coccidiosis resistance problems is increasingly general and serious, and the generation of multiple drug resistance or cross-resistance substantially reduces the service life of medicine.Because coccidiosis very easily develops immunity to drugs to Western medicine, therefore, treatment by Chinese herbs coccidiosis is adopted to become the emphasis of people's research.
Summary of the invention
The technical problem to be solved in the present invention is that chicken long-term taking chemicals of catching an illness can cause drug residue, produce drug resistance, have a strong impact on therapeutic effect, reduce the meat of chicken, the quality of egg product and safety, for solving the problem, the invention provides a kind of Chinese medicine composition being used for the treatment of chicken coccidiosis and preparation method thereof.
The object of the invention is to realize in the following manner:
Be used for the treatment of a Chinese medicine composition for chicken coccidiosis, be made up of the crude drug of following quality proportioning: Radix Dichroae 12 ~ 18 parts, Herba Agrimoniae 9 ~ 21 parts, Fructus Bruceae 6 ~ 9 parts, Herba Artemisiae Annuae 15 ~ 36 parts, Radix Paeoniae 9 ~ 21 parts, Radix Angelicae Sinensis 6 ~ 12 parts, Rhizoma Coptidis 6 ~ 15 parts, Semen Arecae 6 ~ 12 parts, the Radix Aucklandiae 6 ~ 12 parts, Radix Et Rhizoma Rhei 9 ~ 15 parts, Radix Scutellariae 9 ~ 18 parts, Cortex Cinnamomi 6 ~ 12 parts.
Be made up of the crude drug of following quality proportioning: Radix Dichroae 15 parts, Herba Agrimoniae 18 parts, Fructus Bruceae 6 parts, Herba Artemisiae Annuae 27 parts, Radix Paeoniae 18 parts, Radix Angelicae Sinensis 9 parts, Rhizoma Coptidis 9 parts, Semen Arecae 6 parts, the Radix Aucklandiae 6 parts, Radix Et Rhizoma Rhei 9 parts, Radix Scutellariae 12 parts, Cortex Cinnamomi 6 parts.
Concrete operation step is: take each taste medicine according to formula, and mixing after pulverizing, crosses 60 mesh sieves.
The Chinese medicine composition for the treatment of chicken coccidiosis mix with chicken feedstuff to feed and gives chicken food use, and wherein often 100kg chicken feedstuff adds the Chinese medicine composition of 800 ~ 1200g treatment chicken coccidiosis.
The present invention selects effect of raw material to be summarized as follows:
Radix Dichroae: this product is the dry root of saxifragaceae plant Radix Dichroae, cold in nature, acrid in the mouth, hardship, the effect such as have preventing the attack (or recurrence) of malaria, eliminate the phlegm, nature and flavor toil is trembled with fear, poisonous, returns lung, liver, heart channel; Parasite killing, expectorant, removing food stagnancy, appetizing.
Radix Dichroae and halofuginone hydrobromide all have obvious inhibitory action to the zygoblast of Eimeria Tenella, Eimeria Necatrix, the first generation and second filial generation schizont.Trypanosoma evansi in Buffalo can all or part ofly be killed (1:1 decoct is in 1:10 or 1:5 concentration).Have Antimalarial to fowl malaria, duck malaria, monkey malaria and canary malaria, malaria is tired and is about 26 times of quinine, 5 times that its leaf (Ramulus et Folium Dichroae febrifugae) is root.Febrifugine has anti-ameba effect, and comparatively emetine is strong, and therapeutic index is also high, for chicken coccidiosis, rabbit coccidiosis, protozoon dysentery etc.
Herba Agrimoniae: bitter in the mouth, puckery, property is put down.Return lung, liver, spleen channel, have effect of Xu-tonic, astringing to arrest bleeding, detoxification sore treatment, parasite killing.Be mainly used in hemoptysis, haematemesis, epistaxis, hematuria clinically, have blood in stool and metrorrhagia etc.; Treatment dysentery, to control dysentery for its chief, because there being convergence, especially suitable to chronic dysentery unhealed.Modern pharmacology confirms, Herba Agrimoniae is containing agrimophol, agrimonine, tannin and vitamin K etc.Visceral vessel, raising blood pressure can be shunk, heart tonifying, excited breathing; Can blood calcium be increased, make skeletal muscle excited; Can clotting time be accelerated, increase platelet and reach anastalsis.
Fructus Bruceae: be the fruit of Simarubaceae brucea plant Fructus Bruceae; Plant the bitter principle of similar guassin in structure containing more than 30, as bruceine A, B, C, D, E etc., Brusatol, dehydrogenation Brusatol etc., also contain fatty acid as various active compositions such as glycerol trioleate; Nature and flavor are bitter, and cold, mild toxicity, returns large intestine, Liver Channel; Energy heat clearing away, removing toxic substances, parasite killing, preventing the attack (or recurrence) of malaria, erosion wart; Cure mainly toxic-heat and blood stasis, cold-dysentery, chronic dysentery with frequent relapse, malaria, hemorrhoid, carbuncle etc.; Modern pharmacology proves that Fructus Bruceae has the effects such as antitumor, malaria, anti-ameba, antibacterial, antiviral.
Herba Artemisiae Annuae: this product is the herb of feverfew Herba Artemisiae Annuae, property is bitter, cold, has clearing away summer-heat, except effects such as steaming, preventing the attack (or recurrence) of malaria.In recent years in the control of chicken coccidiosis, achieve good effect.The research such as Chen Pudan shows, Herba Artemisiae Annuae and extract is external can effectively suppress coccidian oocyst Sporulated, the anticoccidial index of Herba Artemisiae Annuae injection and Herba Artemisiae Annuae granule is respectively 164.69 and 155.86, effectively can increase survival rate and the body weight increase rate of infected chicken, and the caecum lesion that coccidium infection causes can be alleviated, reduce hemafecia, there is good anticoccidial effect.This product also can strengthen immunologic function, strengthens macrophages phagocytic capacity, improves lymphocytic conversion ratio, increases spleen weight.
Radix Paeoniae: nature and flavor are slightly cold, some is bitter and sour for taste, has nourishing the blood and yin, the effect of pain relieving hepatoprotective.
Radix Angelicae Sinensis: warm in nature, sweet in the mouth is pungent, nontoxic, enriches blood and invigorates blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation, can well along logical inside of human body.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, sometimes, if sensation dysmenorrhea, feels bad especially, Radix Angelicae Sinensis can be selected to use, there is good health-care effect, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.
Rhizoma Coptidis: heat clearing and damp drying, eliminating fire and detoxication, bowel relieving antidiarrheal, suppressing the hyperactive liver improving eyesight.Modern pharmacological research is thought: 1, have broad-spectrum antibacterial action; Anti-bacteria, fungus, virus, fungus, protozoacide; 2, antidiarrheal, stomach invigorating, improves gastric juice, bile secretion, promotes gastrointestinal motility; 3, function of gallbladder promoting, increases bile and is formed and promote bilirubin excretion; 4, immunomodulating, has suppression to leukaemia, antiplatelet aggregation.
Semen Arecae: property is bitter, pungent, temperature; Return stomach, large intestine channel.Expelling intestinal worms and removing food stagnancy, therapeutic method to keep the adverse QI flowing downwards row water, preventing the attack (or recurrence) of malaria; Cure mainly malnutrition due to parasitic infestation, dyspepsia, abdominal distention, after dysentery heavily etc.
The Radix Aucklandiae: pungent, bitter, temperature.Return spleen, stomach, large intestine, three burnt, gallbladder meridians.There are promoting the circulation of QI to relieve pain, effect of strengthening the spleen to promote digestion.For breast gastral cavity distending pain, heavy after dysentery, food stagnation does not disappear, anorexia.The real intestinal antidiarrheal of Radix Aucklandiae (roasted).For stomachache of having loose bowels.
Radix Et Rhizoma Rhei: purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.The main component in, Radix Et Rhizoma Rhei not well for excess-heat constipation, stagnant stomachache, dysentery with catharsis effect is anthraquinone glycoside and dianthracene ketone glycoside, its discharge function act as by force compared with its corresponding glycoside unit. and Radix Et Rhizoma Rhei and Radix Et Rhizoma Rhei treatment acute hemorrhage of upper gastrointestinal tract, all have good haemostatic effect.
Radix Scutellariae: this product tool broad-spectrum antibacterial action, all have bacteriostasis to alpha streptococcus, streptococcus pneumoniae, meningococcus, staphylococcus aureus, diphtheria corynebacterium, vibrio cholera, dysentery bacterium, cattle and sheep pig three type brucella, bacillus pyocyaneus, white scour of chicken bacillus etc., especially to staphylococcus and bacillus pyocyaneus inhibitory action stronger.Also there is inhibitory action to some pathogenic fungus, virus, also have inhibitory or killing effect to leptospira, protozoon etc.Swell for enteritis, pneumonia, brucellosis, influenza, endometritis, conjunctivitis, ophthalmia and inflammation.Also the preventive drug of the white scour of chicken can be used as.
Cortex Cinnamomi: property is pungent, sweet, hot; Return kidney, spleen, the heart, Liver Channel.Have and promote gastrointestinal motility, antiulcer, antiplatelet aggregation, promotion cardiovascular system, strengthen immunologic function, promote the effect such as central nervous system, antiinflammatory, antibacterial, antitumor, slow down aging; Mend fire supporing yang, dispersing cold for relieving pain, warming the meridian and promoting blood circulation; Cure mainly insufficiency of kidney-YANG, the aversion to cold and cold limbs of decline of the fire from the gate of life, soreness of the waist and knees, impotence and seminal emission, dysuria or frequency, dyspnea with rapid and short breath of losing heart, all cards of edema oliguria; Decline of the fire from the gate of life, fire is Gui Yuan not, floating YANG, refusing yang, and heat in the upper and cold in the lower, flushed complexion cold foot, dizziness and tinnitus, and dispute gruel is broken; Spleen-kidney vacuity cold, coldness and pain in the epigastrium, decreased food intake loose stool; Lumbago due to renal deficiency; Arthralgia due to cold-dampnes; Colic of cold type pain; Cold womb is infertile, stomachache of being retarded by silt puerperal; Carbuncle of yin nature multiple abscess, or deficiency and coldness carbuncle and ulcer difficulty in discharging of pus, or do not hold back after bursting.
The present invention adopts Herba Artemisiae Annuae, Radix Dichroae, Herba Agrimoniae, Rhizoma Coptidis, Radix Aucklandiae pure natural Chinese herbal medicine, according to monarch principle composition of prescription.Radix Dichroae, Herba Artemisiae Annuae, the anthelmintic of Fructus Bruceae parasite killing, heat-clearing and toxic substances removing in side, rush down under be monarch drug by worm; Radix Et Rhizoma Rhei cooling blood for hemostasis, to rush down lower intestinal stasis relieving be ministerial drug; Rhizoma Coptidis, Radix Scutellariae heat clearing away are damp and hot, eliminating fire and detoxication, be minister; Chinese angelica blood supplementing nourishes blood, promoting blood circulation and stopping pain, and the Radix Paeoniae Alba is nourished blood yin fluid astringing, easing the affected liver to relieve pain, Cortex Cinnamomi promoting the flow of QI-blood by warming the meridian, Radix Aucklandiae promoting the circulation of QI to relieve pain, and strengthening the spleen to promote digestion is adjuvant drug; Herba Agrimoniae parasite killing removing heat from blood, Semen Arecae invigorating the stomach and promoting digestion, parasite killing are for making medicine.
The present invention have heat clearing and damp drying, parasite killing dysentery relieving, protect the liver, cooling blood for hemostasis, heat-clearing and toxic substances removing effect, scalable body's immunity, being adapted to the mixed infection of prevention and therapy chicken coccidiosis and coccidiosis and antibacterial, treating both the principal and secondary aspects of a disease, is a kind of comparatively ideal anticoccidial preparation.Chinese medicine is the maturation by suppressing unsporulated oocysts, kills Sporulated Oocysts, improves peripheral blood lymphocyte especially T lymphocyte quantity, improves quantity and the activity of T, bone-marrow-derived lymphocyte in immune organ, reaches the object of anticoccidial.Peng Guanghui thinks, compound Chinese medicinal preparation, based on anthelmintic removing toxic substances, is aided with the medicine such as stomach invigorating dampness, dysentery relieving hemostasis, makes it mutual coordination, produce omnibearing coordinative role and transfer the entirety of body advantage factor, thus the effect reaching pest-resistant, treat.Part Chinese herbal medicine can alleviate the clinical symptoms of coccidiosis infection chicken simultaneously.
This product have protect the liver, function of gallbladder promoting, and antiinflammatory, antiallergic, diuresis, calmness, the blood pressure lowering of expansion peripheral blood vessel spoke effect, burnt suppression platelet aggregation.
Relative to prior art, the present invention adopts pure natural Chinese herbal medicine, and crude drug is easy to get, cheap and safety, noresidue, without any side effects to poultry body.Above-mentioned Chinese medicine composition is prepared into powder by the present invention, and method is simple, be easy to operation, is suitable for large-scale production and application.
Detailed description of the invention
Embodiment 1:
The Chinese medicine composition being used for the treatment of chicken coccidiosis of the present embodiment, is made up of the crude drug of following quality proportioning: Radix Dichroae 12 ~ 18 parts, Herba Agrimoniae 9 ~ 21 parts, Fructus Bruceae 6 ~ 9 parts, Herba Artemisiae Annuae 15 ~ 36 parts, Radix Paeoniae 9 ~ 21 parts, Radix Angelicae Sinensis 6 ~ 12 parts, Rhizoma Coptidis 6 ~ 15 parts, Semen Arecae 6 ~ 12 parts, the Radix Aucklandiae 6 ~ 12 parts, Radix Et Rhizoma Rhei 9 ~ 15 parts, Radix Scutellariae 9 ~ 18 parts, Cortex Cinnamomi 6 ~ 12 parts.
Concrete operation step:
Take each taste medicine according to formula, mixing after pulverizing, crosses 60 mesh sieves.
The Chinese medicine composition for the treatment of chicken coccidiosis mix with chicken feedstuff to feed and gives chicken food use, and wherein often 100kg chicken feedstuff adds the Chinese medicine composition of 800 ~ 1200g treatment chicken coccidiosis.
Embodiment 2:
The Chinese medicine composition being used for the treatment of chicken coccidiosis of the present embodiment, is made up of the crude drug of following quality proportioning: Radix Dichroae 180g, Herba Agrimoniae 210g, Fructus Bruceae 90g, Herba Artemisiae Annuae 360g, Radix Paeoniae 210g, Radix Angelicae Sinensis 120g, Rhizoma Coptidis 150g, Semen Arecae 120g, Radix Aucklandiae 120g, Radix Et Rhizoma Rhei 150g, Radix Scutellariae 180g, Cortex Cinnamomi 120g.
The preparation method of above-mentioned Chinese medicine is undertaken by embodiment 1.
The Chinese medicine composition for the treatment of chicken coccidiosis mix with chicken feedstuff to feed and gives chicken food use, and wherein often 100kg chicken feedstuff adds the Chinese medicine composition of 800g treatment chicken coccidiosis.
Embodiment 3:
The Chinese medicine composition being used for the treatment of chicken coccidiosis of the present embodiment, is made up of the crude drug of following quality proportioning: Radix Dichroae 150g, Herba Agrimoniae 180g, Fructus Bruceae 70g, Herba Artemisiae Annuae 270g, Radix Paeoniae 180g, Radix Angelicae Sinensis 90g, Rhizoma Coptidis 140g, Semen Arecae 90g, Radix Aucklandiae 90g, Radix Et Rhizoma Rhei 120g, Radix Scutellariae 150g, Cortex Cinnamomi 90g.
The preparation method of above-mentioned Chinese medicine is undertaken by embodiment 1.
The Chinese medicine composition for the treatment of chicken coccidiosis mix with chicken feedstuff to feed and gives chicken food use, and wherein often 100kg chicken feedstuff adds the Chinese medicine composition of 900g treatment chicken coccidiosis.
Embodiment 4:
The Chinese medicine composition being used for the treatment of chicken coccidiosis of the present embodiment, is made up of the crude drug of following quality proportioning: Radix Dichroae 130g, Herba Agrimoniae 130g, Fructus Bruceae 80g, Herba Artemisiae Annuae 200g, Radix Paeoniae 150g, Radix Angelicae Sinensis 75g, Rhizoma Coptidis 120g, Semen Arecae 75g, Radix Aucklandiae 75g, Radix Et Rhizoma Rhei 100g, Radix Scutellariae 120g, Cortex Cinnamomi 75g.
The preparation method of above-mentioned Chinese medicine is undertaken by embodiment 1.
The Chinese medicine composition for the treatment of chicken coccidiosis mix with chicken feedstuff to feed and gives chicken food use, and wherein often 100kg chicken feedstuff adds the Chinese medicine composition of 1000g treatment chicken coccidiosis.
Embodiment 5:
The Chinese medicine composition being used for the treatment of chicken coccidiosis of the present embodiment, is made up of the crude drug of following quality proportioning: Radix Dichroae 120g, Herba Agrimoniae 90g, Fructus Bruceae 60g, Herba Artemisiae Annuae 150g, Radix Paeoniae 90g, Radix Angelicae Sinensis 60g, Rhizoma Coptidis 90g, Semen Arecae 60g, Radix Aucklandiae 60g, Radix Et Rhizoma Rhei 90g, Radix Scutellariae 90g, Cortex Cinnamomi 60g.
The preparation method of above-mentioned Chinese medicine is undertaken by embodiment 1.
The Chinese medicine composition for the treatment of chicken coccidiosis mix with chicken feedstuff to feed and gives chicken food use, and wherein often 100kg chicken feedstuff adds the Chinese medicine composition of 1200g treatment chicken coccidiosis.
Embodiment 6:
The Chinese medicine composition being used for the treatment of chicken coccidiosis of the present embodiment, is made up of the crude drug of following quality proportioning: Radix Dichroae 170g, Herba Agrimoniae 110g, Fructus Bruceae 65g, Herba Artemisiae Annuae 180g, Radix Paeoniae 120g, Radix Angelicae Sinensis 105g, Rhizoma Coptidis 60g, Semen Arecae 105g, Radix Aucklandiae 105g, Radix Et Rhizoma Rhei 140g, Radix Scutellariae 110g, Cortex Cinnamomi 105g.
The preparation method of above-mentioned Chinese medicine is undertaken by embodiment 1.
The Chinese medicine composition for the treatment of chicken coccidiosis mix with chicken feedstuff to feed and gives chicken food use, and wherein often 100kg chicken feedstuff adds the Chinese medicine composition of 1100g treatment chicken coccidiosis.
Embodiment 7:
The Chinese medicine composition being used for the treatment of chicken coccidiosis of the present embodiment, is made up of the crude drug of following quality proportioning: Radix Dichroae 125, 135, 140, 145, 155, 160, 165, 175g, Herba Agrimoniae 100, 120, 140, 150, 160, 170, 190, 200g, Fructus Bruceae 62, 68, 72, 75, 78, 82, 85, 88g, Herba Artemisiae Annuae 160, 170, 190, 210, 220, 230, 240, 250, 260, 280, 290, 300, 310, 320, 330, 340, 350g, Radix Paeoniae 100, 110, 130, 140, 160, 170, 190, 200g, Radix Angelicae Sinensis 65, 70, 80, 85, 95, 100, 110, 115g, Rhizoma Coptidis 70, 80, 95, 105, 110, 115, 125, 130, 135, 145g, Semen Arecae 65, 70, 80, 85, 95, 100, 110, 115g, the Radix Aucklandiae 65, 70, 80, 85, 95, 100, 110, 115g, Radix Et Rhizoma Rhei 95, 105, 110, 115, 125, 130, 135, 145g, Radix Scutellariae 100, 130, 140, 160, 170g, Cortex Cinnamomi 65, 70, 80, 85, 95, 100, 110, 115g.
The preparation method of above-mentioned Chinese medicine is undertaken by embodiment 1.
The Chinese medicine composition for the treatment of chicken coccidiosis mix with chicken feedstuff to feed and gives chicken food use, wherein often 100kg chicken feedstuff add 850,950,1050, the Chinese medicine composition of 1150g treatment chicken coccidiosis.
Clinical experimental study
1 materials and methods
1.1 experimental animal
Healthy 817 meat of 11 ages in days are mixed chicken 700, and by Zhengzhou, laboratory animal supply center of animal husbandry engineering college provides, and 3d excrement inspection continuously before administration, confirms that non-ball worm infects.
1.2 egg capsule
Thered is provided by Agricultural University Of He'nan's parasite laboratory, include Eimeria tenella Sporulated coccidian oocyst, before use rejuvenation in cockerel body, be separated and be placed in 25g/L potassium bichromate solution, count after Sporulated, be stored among 4 DEG C of refrigerators.
1.3 trial drug
Adopt powder prepared by embodiment 2 ~ 4 respectively.
1.4 contrast medicines
Diclazuril pre-mixing agent produces (specification: 100g:5g by Zhengzhou Houyi Pharmaceutical Co., Ltd.; Lot number: 20130521), therapeutic dose is that every 100kg chicken feedstuff adds 2g diclazuril pre-mixing agent.
2 test methods
2.1 test groupings
11 age in days 817 meat purchased to be mixed chicken 700, do not divide into groups after raising 3d with the feedstuff adaptability containing anticoccidial drug.Grouping started to take every chicken body weight the same day, and selective body is great little close strong young 600, is divided into 8 groups at random, namely blank group, positive controls and embodiment 2 ~ 4 preparation powder and drug control group, often organize chicken number in table 1.Grouping terminates namely to carry out artificial challenge and therapeutic test.
2.2 artificial challenges and therapeutic test
Except blank group, every test chicken equal per oral inoculation 0.2mLE.tenella Sporulated Oocysts suspension during other 7 groups of 15 ages in days (containing Sporulated Oocysts 8.0 × 104/only).Infect the same day of coccidian oocyst, immediately each group of chicken is carried out to the treatment of medicine and control drug according to above-mentioned grouping situation.Except blank group and positive controls, the high, medium and low dosage component of embodiment 3 does not add 2000,1000,500g spice mixed feeding according to every 100kg feedstuff; Loose dosage component prepared by embodiment 2,4 does not add 1000 spice mixed feedings according to every 100kg feedstuff, is used in conjunction 5d.After infecting every day checkout facility chicken spirit, the promoting the circulation of blood of going forward side by side of appetite, feces just scores, after administration the 8th day, start to weigh, calculate the survival rate of each group, rate of body weight gain; And chicken is all slaughtered cut open inspection, observe and carry out that caecum lesion is scored, hemafecia is scored; Calculate caecum egg sac number, egg capsule than number, egg capsule value and anticoccidial index (ACI).
2.3 evaluating drug effect indexs
2.3.1 survival rate
Survival rate (%)=(in group internal memory live chickens number/group test chicken sum) × 100%.
2.3.2 body weight increase rate
Body weight increase rate=(average weight gain of the average weight gain/blank group of each infected group) × 100%.
2.3.3 feces is scored
With reference to the standard of Morehouse, namely the 4th day after artificial challenge starts to observe blood stool situation, and by the most serious once the scoring of hemafecia, and calculate full cell mean, feces normally remembers 0 point; This every, sky chicken on average occurs that how much piling hemafecia just remembers how many points respectively.
2.3.4 caecum lesion is scored
With reference to the method for Johnson and Reid, score (0 ~ 4) according to cuing open the rear caecum lesion situation of inspection: have no pathological changes, remember 0 point; Caecum wall has minute quantity petechial hemorrhage speckle, and intestinal wall does not thicken, and other are normal, remember 1 point; Cecal content is with a small amount of blood, and caecum wall slightly thickens, visible most ecchymosis, remembers 2 points; Have volume blood or caecum core in caecum, the plump and obvious caecum of caecum wall is out of shape and atrophy, remembers 3 points; The remarkable atrophy of caecum, pathological changes is gone directly intestines, and intestinal wall is extremely plump, containing blood clot or caecum core in caecum, remembers 4 points.Chicken dead in experimental period cuts open inspection at any time, and all chickens because of Caecum Coccidiosis death, pathological changes remembers 4 points.Score according to caecum lesion, calculate full group average lesion and score, then obtain pathological changes value.Complete group of average lesion score=and full group lesion score summation/full group observes chicken number; Pathological changes value=entirely organize average lesion to score × 10.
2.3.5 egg capsule value
After off-test, slaughter whole chicken, cut off caecum, scraping content, homogenate, calculate egg capsule 1,000,000 number in every caecum homogenate, draw egg capsule value.In every caecum homogenate, egg capsule 1,000,000 number is less than 0.1, and egg capsule value is 0; In every caecum homogenate, egg capsule 1,000,000 number is 0.1 ~ 1.0, and egg capsule value is 1; In every caecum homogenate, egg capsule 1,000,000 number is 2.0 ~ 5.0, and egg capsule value is 10; In every caecum homogenate, egg capsule 1,000,000 number is 6.0 ~ 10.0, and egg capsule value is 20; In every caecum homogenate, egg capsule 1,000,000 number is greater than 11.0, and egg capsule value is 40.
2.3.6 anticoccidial index
Anticoccidial index (ACI)=(body weight increase rate+survival rate)-(pathological changes value+egg capsule value).
2.4 evaluation of result
Judge the effect of anticoccidial according to ACI: ACI>180, anticoccidial is efficient; ACI is 160 ~ 180, imitates in anticoccidial; ACI is 120 ~ 160, anticoccidial poor efficiency; ACI<120, anticoccidial is invalid.
3 results and analysis
The treatment situation of 3.1 chicken coccidiosis and result of the test
After test chicken inoculation coccidiosis 3 days, it is depressed that chicken shows spirit, and feather pine disorderly, fear of cold, to flock together, and diet is even absolutely useless for declining, and dysentery, hemafecia then occur.Dead 5 of positive controls, the chicken that dies of illness is cutd open inspection and sees the obvious enlargement of caecum, hemorrhage or have blood clot.After the medication of each administration group, clinical symptoms alleviates gradually.Infect latter 4th day, start to record test index; Within 8th day, weigh, catch and kill, observe caecum lesion and score, take cecal content to measure egg capsule value simultaneously, the results are shown in Table 1.
The therapeutic effect of coccidiosis resisted by table 1
3.2 interpretations of result and discussion
High in embodiment 3 groups, middle dosage group ACI value is 186.1 and 180.5, for anticoccidial is efficient; Embodiment 2, embodiment 4, control group A CI value 161.9,175.6,163.5, for imitating in anticoccidial; The ACI value of embodiment 3 groups of low dose group is respectively 148.3, is anticoccidial poor efficiency.This result of the test shows, embodiment 3 is high, middle dosage group all can prevent and treat Eimeria Tenella disease well, and can prevent rate of body weight gain from reducing, the rate of body weight gain of two groups is close, all higher than embodiment 2, embodiment 4, matched group; The present invention is pure Chinese powder medicine, and toxic and side effects is little, low-residual, not easily produce drug resistance.Recommend its best dosage to be dosage in test group, namely by 1.0% spice, mixed feeding, is used in conjunction 5 ~ 7d.
Claims (4)
1. be used for the treatment of a Chinese medicine composition for chicken coccidiosis, it is characterized in that: be made up of the crude drug of following quality proportioning: Radix Dichroae 12 ~ 18 parts, Herba Agrimoniae 9 ~ 21 parts, Fructus Bruceae 6 ~ 9 parts, Herba Artemisiae Annuae 15 ~ 36 parts, Radix Paeoniae 9 ~ 21 parts, Radix Angelicae Sinensis 6 ~ 12 parts, Rhizoma Coptidis 6 ~ 15 parts, Semen Arecae 6 ~ 12 parts, the Radix Aucklandiae 6 ~ 12 parts, Radix Et Rhizoma Rhei 9 ~ 15 parts, Radix Scutellariae 9 ~ 18 parts, Cortex Cinnamomi 6 ~ 12 parts.
2. the Chinese medicine composition being used for the treatment of chicken coccidiosis according to claim 1, is characterized in that: be made up of the crude drug of following quality proportioning: Radix Dichroae 15 parts, Herba Agrimoniae 18 parts, Fructus Bruceae 6 parts, Herba Artemisiae Annuae 27 parts, Radix Paeoniae 18 parts, Radix Angelicae Sinensis 9 parts, Rhizoma Coptidis 9 parts, Semen Arecae 6 parts, the Radix Aucklandiae 6 parts, Radix Et Rhizoma Rhei 9 parts, Radix Scutellariae 12 parts, Cortex Cinnamomi 6 parts.
3. the preparation method being used for the treatment of the Chinese medicine composition of chicken coccidiosis according to claim 1 and 2, is characterized in that: concrete operation step is: take each taste medicine according to formula, and mixing after pulverizing, crosses 60 mesh sieves.
4. the application being used for the treatment of the Chinese medicine composition of chicken coccidiosis according to claim 1 and 2, it is characterized in that: the Chinese medicine composition for the treatment of chicken coccidiosis mix with chicken feedstuff to feed and gives chicken food use, and wherein often 100kg chicken feedstuff adds the Chinese medicine composition of 800 ~ 1200g treatment chicken coccidiosis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410559909.0A CN104337967A (en) | 2014-10-21 | 2014-10-21 | Traditional Chinese medicine composition for treating coccidiosis in chicken and preparation method of traditional Chinese medicine composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410559909.0A CN104337967A (en) | 2014-10-21 | 2014-10-21 | Traditional Chinese medicine composition for treating coccidiosis in chicken and preparation method of traditional Chinese medicine composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104337967A true CN104337967A (en) | 2015-02-11 |
Family
ID=52494958
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410559909.0A Pending CN104337967A (en) | 2014-10-21 | 2014-10-21 | Traditional Chinese medicine composition for treating coccidiosis in chicken and preparation method of traditional Chinese medicine composition |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104337967A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107865250A (en) * | 2017-12-15 | 2018-04-03 | 安徽金冠农牧科技有限公司 | A kind of feed for preventing and treating chicken coccidiasis and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102885914A (en) * | 2012-10-30 | 2013-01-23 | 天津生机集团股份有限公司 | Traditional Chinese medicine oral liquid for treating chicken coccidiosis and preparation method thereof |
| CN103285255A (en) * | 2013-05-06 | 2013-09-11 | 安徽华澳生物技术有限公司 | Anti-coccidiosis pharmaceutical composition as well as preparation method and use thereof |
| CN103830378A (en) * | 2014-03-25 | 2014-06-04 | 烟台金海药业有限公司 | Chinese veterinary medicine superfine powder for treating chicken caecal coccidiosis and preparation method thereof |
-
2014
- 2014-10-21 CN CN201410559909.0A patent/CN104337967A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102885914A (en) * | 2012-10-30 | 2013-01-23 | 天津生机集团股份有限公司 | Traditional Chinese medicine oral liquid for treating chicken coccidiosis and preparation method thereof |
| CN103285255A (en) * | 2013-05-06 | 2013-09-11 | 安徽华澳生物技术有限公司 | Anti-coccidiosis pharmaceutical composition as well as preparation method and use thereof |
| CN103830378A (en) * | 2014-03-25 | 2014-06-04 | 烟台金海药业有限公司 | Chinese veterinary medicine superfine powder for treating chicken caecal coccidiosis and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 张泉鑫 等: "《中西结合兽医宝鉴》", 31 January 2013, 中国农业出版社 * |
| 梁崇杰 等: "《畜禽常见病土法良方3000例》", 30 September 2006, 四川科学技术出版社 * |
| 鞠躬尽瘁在路上: "鸡球虫病诊断及其综合防治措施", 《百度文库》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107865250A (en) * | 2017-12-15 | 2018-04-03 | 安徽金冠农牧科技有限公司 | A kind of feed for preventing and treating chicken coccidiasis and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104208238B (en) | A kind of for Chinese medicine composition treating chicken coccidiosis and preparation method thereof | |
| CN104012798B (en) | Be used for the treatment of the feed of Gilt Uterus intimitis, Chinese medicine composition and preparation method | |
| CN103721045B (en) | For improving the Chinese traditional immunopoteniators of broiler immunologic function in growth course | |
| CN103239651B (en) | Traditional Chinese medicine for treating subclinical mastitis for dairy cow | |
| CN105012673A (en) | Traditional Chinese medicine for preventing and treating mycotoxicosis of domestic animals and preparation method of traditional Chinese medicine | |
| CN105028995A (en) | Mixed dog food and preparation method thereof | |
| CN102552657B (en) | Chinese medicinal composition used for treating Newcastle disease of chicken | |
| CN108210764A (en) | A kind of Chinese medicine composition for treating chicken coccidiasis and preparation method thereof | |
| CN105920316B (en) | The Chinese materia medica preparation for improving milk cow immunity, preventing mastitis for milk cows | |
| CN104337967A (en) | Traditional Chinese medicine composition for treating coccidiosis in chicken and preparation method of traditional Chinese medicine composition | |
| CN103652490A (en) | Pig feed for treating blue-eared pig disease and preparation method thereof | |
| CN103599362A (en) | Traditional Chinese medicine composition for treating swine enzootic pneumonia and preparation method thereof | |
| CN103301385A (en) | Traditional Chinese medicine composition for treating animal diarrhea and preparation method thereof | |
| CN104082529A (en) | Feed for controlling piglet's yellow-white dysentery | |
| CN102657772B (en) | Decoction for treating avian staphylocosis, feed and preparation method | |
| CN104288719A (en) | Traditional Chinese medicine composition for treating chronic enteritis | |
| CN104222632B (en) | Feed for preventing coccidiosis of rabbits | |
| CN103845647A (en) | Traditional Chinese medicine for treating infantile anorexia caused by dysfunction of spleen in transportation | |
| CN105056093A (en) | Medicine for treating chronic gastric and duodenal ulcer and preparing method thereof | |
| CN104800362A (en) | Veterinary traditional Chinese medicine composition, traditional Chinese medicine powder and preparation method and application thereof | |
| CN105288048B (en) | Traditional Chinese medicine compound oral liquid for preventing and treating calf diarrhea | |
| CN103705820B (en) | Medicine being used for the treatment of yellow scour of piglet and preparation method thereof | |
| CN104068283A (en) | Fodder, traditional Chinese medicine composition, preparation method and application, used for preventing and curing sheep pox | |
| CN103877545A (en) | Traditional Chinese medicinal composition for treating poultry diarrhea and preparation method thereof | |
| CN104644983A (en) | Traditional Chinese medicine oral liquid for treating white scour of piglet and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150211 |