CN103191240B - Traditional Chinese veterinary medicine oral solution for preventing and treating viral diseases of poultry - Google Patents
Traditional Chinese veterinary medicine oral solution for preventing and treating viral diseases of poultry Download PDFInfo
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Abstract
The invention belongs to the field of traditional Chinese veterinary medicines, and in particular discloses a traditional Chinese veterinary medicine oral solution for preventing and treating viral diseases of poultry. The traditional Chinese medicine is composed of a liquid medicine A and a liquid medicine B, wherein the active ingredients of the liquid medicine A are composed of astragalus mongholicus, semen raphani, white paeony root, sanguisorba officinalis, herba epimedii, radix bupleuri, fructus aurantii, and liquorice; the active ingredients of the liquid medicine B are composed of coptis chinensis, rheum officinale, polygonum cuspidatum, cyrtomium fortunei, honeysuckle, fructus forsythiae, and houttuynia cordata. The traditional Chinese veterinary medicine oral solution disclosed by the invention is mainly used for treating the viral diseases of poultry and safe in use, avoids western medicine residues to guarantee the security of meat and eggs, has an obvious and durable curative effect, is fast to be absorbed, works rapidly, has strong effects, is simple to take, has sufficient medicine sources, is proper in price, and can be used for treating the viral diseases of poultry fundamentally and preventing and treating the viral diseases, such as Newcastle disease and duck virus hepatitis, of poultry.
Description
(1) technical field
The invention belongs to field of traditional Chinese veterinary, particularly a kind of herbal medicine oral liquid of preventing and treating poultry virus disease.
(2) background technology
Poultry virus disease is the most serious disease of harm China's aviculture, although vaccine has been brought into play important function in controlling viral disease, but because virus serotype is many, be easy to the various reasons such as variation, maternal antibody interference, vaccine improper use, immunosuppressant, the phenomenon of clinical immuning failure occurs repeatedly, to aviculture, has brought huge economic loss.
Existing chemical antiviral Western medicine, as ribavirin, amantadine, moroxydine hydrochloride etc., not only still imprecise to the curative effect of many animality diseases, be easy to produce drug resistance, and toxic and side effects is stronger, China has forbidden being used as for animals, and therefore seeking novel antiviral herbal medicine preparation has safely and efficiently been extremely urgent.
(3) summary of the invention
The present invention, in order to make up the deficiencies in the prior art, provides a kind of simple, to use safety, lasting control poultry virus disease evident in efficacy herbal medicine oral liquid of preparing.
The present invention is achieved through the following technical solutions:
Prevent and treat a herbal medicine oral liquid for poultry virus disease, by A medicinal liquid and B medicinal liquid, formed,
Its active component of A medicinal liquid is comprised of the raw material of following parts by weight:
16～24 parts of the Radixs Astragali, 16～24 parts of Semen Raphanis, 8～12 parts of the Radix Paeoniae Albas, 8～12 parts of Radix Sanguisorbaes, 8～12 parts of Herba Epimedii, 8～12 parts of Radix Bupleuri, 8～12 parts of Fructus Aurantiis, 8～12 parts, Radix Glycyrrhizae;
Its active component of B medicinal liquid is comprised of the raw material of following parts by weight:
12～18 parts of Rhizoma Coptidis, 12～18 parts of Radix Et Rhizoma Rhei, 12～18 parts of Rhizoma Polygoni Cuspidati, 12～18 parts of Rhizoma Osmundae, 12～18 parts of Flos Loniceraes, 10～15 parts of Fructus Forsythiaes, 10～15 parts of Herba Houttuyniae.
The herbal medicine oral liquid of this control poultry virus disease, is comprised of A medicinal liquid and B medicinal liquid, and the weight proportion of its preferred each active component is:
Its active component of A medicinal liquid is comprised of the raw material of following parts by weight:
20 parts of the Radixs Astragali, 20 parts of Semen Raphanis, 10 parts of the Radix Paeoniae Albas, 10 parts of Radix Sanguisorbaes, 10 parts of Herba Epimedii, 10 parts of Radix Bupleuri, 10 parts of Fructus Aurantiis, 10 parts, Radix Glycyrrhizae;
Its active component of B medicinal liquid is comprised of the raw material of following parts by weight:
15 parts of Rhizoma Coptidis, 15 parts of Radix Et Rhizoma Rhei, 15 parts of Rhizoma Polygoni Cuspidati, 15 parts of Rhizoma Osmundae, 15 parts of Flos Loniceraes, 12 parts of Fructus Forsythiaes, 12 parts of Herba Houttuyniae.
The preparation method of the herbal medicine oral liquid of this control poultry virus disease, comprises the steps:
(1) each raw material of above-mentioned weight in A medicinal liquid is inserted in Chinese medicine extracting tank together, add 7 times of water gagings, soak 1 hour, decoct, boil rear maintenance 1 hour, tapping, filters; Medicinal residues add 3 times of water gagings again, continue to boil 0.5 hour, and tapping, filters; Merge decocting liquid twice, concentrating under reduced pressure, to relative density of medicine liquid approximately 1.10 left and right, filters, and adds sodium benzoate anticorrosion in filtrate, and filtrate, with bottle fill, obtains A medicinal liquid;
(2) each raw material of above-mentioned weight in B medicinal liquid is inserted in Chinese medicine extracting tank together, add 7 times of water gagings, soak 1 hour, decoct, boil rear maintenance 1 hour, tapping, filters; Medicinal residues add 3 times of water gagings again, continue to boil 0.5 hour, and tapping, filters; Merge decocting liquid twice, concentrating under reduced pressure, to relative density of medicine liquid approximately 1.10 left and right, filters, and adds sodium benzoate anticorrosion in filtrate, and filtrate, with bottle fill, obtains B medicinal liquid;
(3) by A medicinal liquid, B medicinal liquid in 1: 1 ratio supporting packing in same packing crates.
Usage and dosage: every morning is used A medicinal liquid drinking-water, and dosage is every kg body weight 0.5ml; Use B medicinal liquid drinking-water afternoon, dosage is every kg body weight 0.5ml, is used in conjunction 7 days.
Herbal medicine oral liquid of the present invention is specifically designed to treatment poultry virus disease, multi-medicament is suitably coordinated, utilize its mutual collaborative or resistant function, improve curative effect, to adapt to the treatment requirement of the complicated state of an illness, reduce untoward reaction, have no side effect, use safety, avoided Western medicine residual, ensured the safety of meat and egg production, evident in efficacy lasting, absorb fast, prove effective rapidly, effect is strong, take simple, medicine source is sufficient, price is suitable, can fundamentally treat poultry virus disease, can be used for poultry newcastle, the control of the viral diseases such as duck viral hepatitis.
(4) specific embodiment
Embodiment 1:
The preparation method of the herbal medicine oral liquid of this control poultry virus disease, comprises the steps:
(1) take 20 kilograms of the Radixs Astragali, 20 kilograms of Semen Raphanis, 10 kilograms of the Radix Paeoniae Albas, 10 kilograms of Radix Sanguisorbaes, 10 kilograms of Herba Epimedii, 10 kilograms of Radix Bupleuri, 10 kilograms of Fructus Aurantiis, 10 kilograms, Radix Glycyrrhizae, insert together in Chinese medicine extracting tank, add 7 times of water gagings, soak 1 hour, decoct, boil rear maintenance 1 hour, tapping, filters; Medicinal residues add 3 times of water gagings again, continue to boil 0.5 hour, and tapping, filters; Merge decocting liquid twice, put in concentration tank, concentrating under reduced pressure, to relative density of medicine liquid approximately 1.10 left and right, filters, and in filtrate, adding mass fraction is that 0.3% sodium benzoate aqueous solution is anticorrosion, and filtrate, with the fill of 500ml white liquid medicinal bottle, obtains A medicinal liquid;
(2) take 15 kilograms of Rhizoma Coptidis, 15 kilograms of Radix Et Rhizoma Rhei, 15 kilograms of Rhizoma Polygoni Cuspidati, 15 kilograms of Rhizoma Osmundae, 15 kilograms of Flos Loniceraes, 12 kilograms of Fructus Forsythiaes, 12 kilograms of Herba Houttuyniae, insert together in Chinese medicine extracting tank, add 7 times of water gagings, soak 1 hour, decoct, boil rear maintenance 1 hour, tapping, filters; Medicinal residues add 3 times of water gagings again, continue to boil 0.5 hour, and tapping, filters; Merge decocting liquid twice, put in concentration tank, concentrating under reduced pressure, to relative density of medicine liquid approximately 1.10 left and right, filters, and in filtrate, adding mass fraction is that 0.3% sodium benzoate aqueous solution is anticorrosion, and filtrate, with the fill of 500ml brown liquid medicinal bottle, obtains B medicinal liquid;
(3) 15 bottles of white bottle A medicinal liquids and 15 bottles of palm fibre bottle B medicinal liquids are packed in same packing crates.
Usage and dosage: every morning is used A medicinal liquid drinking-water, and dosage is every kg body weight 0.5ml; Use B medicinal liquid drinking-water afternoon, dosage is every kg body weight 0.5ml, is used in conjunction 7 days.Drink A medicinal liquid the morning, yang invigorating consolidating superficial resistance, dispersing the stagnated live-QI to relieve the stagnation of QI, can alleviate accumulating of the interior noxious substance of poultry body at night, increases feed intake, the recovery of invigorating health effectively; Drink B medicinal liquid afternoon, heat-clearing and toxic substances removing, virus replication, reduces death at night.
The herbal medicine oral liquid of this control poultry virus disease is for poultry virus prevention and treatment of diseases such as newcastle disease, duck viral hepatitiss.
Embodiment 2:
The herbal medicine oral liquid of this control poultry virus disease, is comprised of A medicinal liquid and B medicinal liquid,
Its active component of A medicinal liquid is comprised of the raw material of following weight:
16 kilograms of the Radixs Astragali, 16 kilograms of Semen Raphanis, 9 kilograms of the Radix Paeoniae Albas, 9 kilograms of Radix Sanguisorbaes, 9 kilograms of Herba Epimedii, 11 kilograms of Radix Bupleuri, 11 kilograms of Fructus Aurantiis, 11 kilograms, Radix Glycyrrhizae;
Its active component of B medicinal liquid is comprised of the raw material of following weight:
12 kilograms of Rhizoma Coptidis, 12 kilograms of Radix Et Rhizoma Rhei, 16 kilograms of Rhizoma Polygoni Cuspidati, 16 kilograms of Rhizoma Osmundae, 16 kilograms of Flos Loniceraes, 10 kilograms of Fructus Forsythiaes, 10 kilograms of Herba Houttuyniae.
Preparation method and usage and dosage are with embodiment 1.
Embodiment 3:
The herbal medicine oral liquid of this control poultry virus disease, is comprised of A medicinal liquid and B medicinal liquid,
Its active component of A medicinal liquid is comprised of the raw material of following weight:
24 kilograms of the Radixs Astragali, 24 kilograms of Semen Raphanis, 8 kilograms of the Radix Paeoniae Albas, 8 kilograms of Radix Sanguisorbaes, 8 kilograms of Herba Epimedii, 8 kilograms of Radix Bupleuri, 8 kilograms of Fructus Aurantiis, 8 kilograms, Radix Glycyrrhizae;
Its active component of B medicinal liquid is comprised of the raw material of following weight:
18 kilograms of Rhizoma Coptidis, 18 kilograms of Radix Et Rhizoma Rhei, 18 kilograms of Rhizoma Polygoni Cuspidati, 12 kilograms of Rhizoma Osmundae, 12 kilograms of Flos Loniceraes, 15 kilograms of Fructus Forsythiaes, 15 kilograms of Herba Houttuyniae.
Preparation method and usage and dosage are with embodiment 1.
Embodiment 4:
The herbal medicine oral liquid of this control poultry virus disease, is comprised of A medicinal liquid and B medicinal liquid,
Its active component of A medicinal liquid is comprised of the raw material of following weight:
18 kilograms of the Radixs Astragali, 22 kilograms of Semen Raphanis, 12 kilograms of the Radix Paeoniae Albas, 12 kilograms of Radix Sanguisorbaes, 12 kilograms of Herba Epimedii, 12 kilograms of Radix Bupleuri, 12 kilograms of Fructus Aurantiis, 12 kilograms, Radix Glycyrrhizae;
Its active component of B medicinal liquid is comprised of the raw material of following weight:
13 kilograms of Rhizoma Coptidis, 17 kilograms of Radix Et Rhizoma Rhei, 12 kilograms of Rhizoma Polygoni Cuspidati, 18 kilograms of Rhizoma Osmundae, 18 kilograms of Flos Loniceraes, 14 kilograms of Fructus Forsythiaes, 13 kilograms of Herba Houttuyniae.
Preparation method and usage and dosage are with embodiment 1.
The present invention prevents and treats the mechanism of action of the herbal medicine oral liquid of poultry virus disease: A medicinal liquid benefit is defended consolidating superficial resistance, ascending up spleen-Qi and Yang, dispersing the stagnated live-QI to relieve the stagnation of QI, cooling blood for hemostasis, invigorating the spleen and regulating the stomach, the fever that viral infection is caused, hemorrhage, the decline of searching for food, hypoimmunity, organ dysfunction are lost and in disorder etc. are had rapid repair function, can effectively reduce mortality rate; B medicinal liquid clearing away heat-damp and promoting diuresis, eliminating fire and detoxication, dampness removing heat from blood, dispelling wind eliminating stagnation, propagation that can the multiple virus of strong inhibition.Two medicinal liquids coordinate can kill virus, and relief of symptoms, repairs damage, and promote body to search for food, improve resistance, thereby has the rapid effect dead, that Cure Viruses infects that reduces.
With regard to effect of drugs of the present invention, further do following explanation below:
(I) In-vitro Inhibitory Effect of oral liquid of the present invention to Avian pneumo-encephalitis virus (NDV):
By oral liquid B medicinal liquid of the present invention and NDV first test tube moderate immixture 30 minutes, again mixed liquor is inoculated to 11 age in days SPF chick embryo allantoic cavities, put in couveuse and continue to hatch, after 96 hours as a result, Embryo Gallus domesticus is all survived, it is 0 that HA tires, and all death in 48 hours of virus control group Embryo Gallus domesticus, it is 8.0 that HA tires.Result shows, oral liquid of the present invention has direct deactivation to NDV in vitro.
Oral liquid B medicinal liquid of the present invention is first inoculated in to SPF chick embryo allantoic cavity, hatches and inoculate NDV after 1 hour, put in couveuse and continue to hatch, after 96 hours as a result, Embryo Gallus domesticus survival rate is 50%, in allantoic fluid, NDV blood clotting valency is 3.5, and all death in 48 hours of matched group Embryo Gallus domesticus, blood clotting valency is 7.5.Result of the test shows, oral liquid of the present invention has obvious inhibitory action to NDV propagation in Embryo Gallus domesticus.
The two kinds of different equal proved invention of egg inoculation method oral liquids have good inhibitory action in vitro to NDV.
(II) In-vitro Inhibitory Effect of oral liquid of the present invention to H9 bird flu virus:
By the H9 type bird flu virus of 5000 times of dilutions and oral liquid B medicinal liquid of the present invention mixed in equal amounts 30 minutes in vitro, inoculate 11 age in days SPF Embryo Gallus domesticus, every embryo 0.2mL, 37 ℃ are continued hatching, after 96 hours as a result, Embryo Gallus domesticus is all survived, in allantoic fluid, viral hemoagglutination valency is 0, and 48 hours Embryo Gallus domesticus of virus control group are all dead, and in allantoic fluid, viral hemoagglutination valency is 9.7.Both differences are extremely remarkable, and Embryo Gallus domesticus test shows that oral liquid of the present invention has good In-vitro Inhibitory Effect to H9 bird flu virus.
(III) clinical effect trial of oral liquid of the present invention to artificial challenge's newcastle disease:
A) experimental animal: the healthy cockerel of 25 age in days Hai Lanbai, without any vaccine immunity.
B) virus: Avian pneumo-encephalitis virus F48E8 strain, it is 1: 256 that HA tires.
C) test method:
(a) test grouping: test chickling is divided into drug test group, counteracting toxic substances matched group and blank group at random, 30 every group.
(b) counteracting toxic substances: NDV is done to 10
-4dilution, every thoracic muscle injection 0.1mL.
(c) gavage medicine: 3 days from counteracting toxic substances start, drug test group every morning gavages A medicinal liquid 1ml, gavages B medicinal liquid 1ml afternoon, is used in conjunction 7 days; Counteracting toxic substances matched group is not used any medicine, gavages normal saline 1ml at every turn, the upper and lower noon each 1 time, is used in conjunction 7 days.
(d) clinical observation: after counteracting toxic substances, observe the clinical symptoms of respectively organizing chicken every day, records death condition, and chicken is cutd open inspection to dying of illness.
D) result of the test:
After counteracting toxic substances the 3rd day, each was organized chicken group and all shows obvious clinical symptoms, and mine massively appetite, amount of drinking water of chicken declines, sick chicken down in spirits, drop-head are closed one's eyes, are flocked together, and indivedual chickens are lied prostrate on the ground, dyspnea, send the moist rale of " snore snore ", indivedual chickens sound of stridulating.Counteracting toxic substances matched group is compared with drug test group, and symptom is obviously serious, and death is many.The typical cytopathic such as the chicken that dies of illness cuts open that inspection all shows as that glandular stomach is hemorrhage, Semen Jujubae shape ulcer appears in intestinal diffuse hemorrhage, lymphoid tissue, cecal tonsil swelling is hemorrhage.After counteracting toxic substances 10 days, survival chicken recovers normal.Drug test group chickling survival rate is 36.7%, and counteracting toxic substances matched group survival rate is 6.7%, both significant differences.Chicken death toll refers to following table 1:
Table 1 newcastle disease Experimental infection efficacy result
| Group | Chickling sum | Death toll | Survival number | Survival rate (%) |
| Drug test group | 30 | 19 | 11 | 36.7 |
| Counteracting toxic substances matched group | 30 | 28 | 2 | 6.7 |
| Blank group | 30 | 0 | 30 | 100 |
Newcastle disease Experimental infection shows, oral liquid of the present invention has good prevention effect to newcastle.
(IV) therapeutic effect of the present invention to newcastle natural occurrence chicken group:
In Laiwu in Shandong province, the various places such as Weifang, Yantai, Linyi, chronic newcastle natural occurrence chicken group has been carried out to expansion Clinical Treatment Test with oral liquid of the present invention, use A medicinal liquid the morning, use B medicinal liquid afternoon, concentrate drinking-water medication, dosage is every kg body weight 0.5ml, treat altogether 4450 of disease chickens, cure 4312, dead 138, cure rate average out to 96.9%.General medication is after 2 days, and death starts to decline, and feed intake starts to rise, and after medication 4-5 days, chicken group recovers normally, to have obtained good curative effect substantially, and concrete therapeutic effect is in Table 2:
Table 2 newcastle disease clinical effect trial result
| Place | Chicken group quantity | Cure number | Death toll | Cure rate (%) |
| Weifang chicken house | 1500 | 1466 | 34 | 97.7 |
| Laiwu chicken house | 1200 | 1151 | 49 | 95.9 |
| Yantai raiser | 800 | 771 | 29 | 96.4 |
| Linyi raiser | 950 | 924 | 26 | 97.3 |
| Sum | 4450 | 4312 | 138 | 96.9 |
Model case:
Case 1: Heze plant, only raise AA broiler chicken more than 15000,26 ages in days, chicken group sudden onset, sick chicken spirit is depressed, and feed intake declines, and has respiratory symptom, draws green loose stool, dead five, 60 of every day.Cut open and examine the chicken that dies of illness, glandular stomach thelorrhagia, muscular stomach horny layer ulcer, has hemorrhage speckle under horny layer, whole intestinal diffuse hemorrhage, intestinal mucosa comes off, and cecal tonsil swelling is hemorrhage, and myocardium crown fat is hemorrhage, and trachea hyperemia is hemorrhage.According to clinical symptoms and cut open inspection pathological changes, be diagnosed as newcastle disease.Bring into use malicious gram+lomefloxacin hydrochloride drinking-water, be used in conjunction after 2 days, the dead quantity of chicken group further increases, and chicken group is without being clearly better.Use immediately oral liquid of the present invention instead and treat, use white bottle A medicinal liquid the morning, every each 0.5ml of chicken, concentrates drinking-water; Use palm fibre bottle B medicinal liquid afternoon, every each 0.5ml of chicken, concentrates drinking-water, is used in conjunction 7 days.After medication 3 days, chicken is dead obviously to decline, and feed intake significantly increases, and after medication the 7th day, it is normal that chicken group recovers completely.
Case 2: Jinan Shanghe raiser, raise 5000 of 817 broiler chicken, during 35 age in days, start morbidity, chicken group spirit is depressed, and feed intake declines, and draws green loose stool, there is turn-taking, turning round the nervous symptoms such as neck in indivedual chickens, only, cut open and examine the chicken that dies of illness every day dead more than 30, the slight bleeding of glandular stomach nipple, muscular stomach horny layer bleed bottom, intestinal mucosa is hemorrhage, there is Semen Jujubae shape ulcer in some gut associated lymphatic tissues, cecal tonsil swelling is hemorrhage, and heart is hemorrhage, tunica mucosa tracheae is hemorrhage, through clinical diagnosis, is chronic newcastle.Use immediately oral liquid of the present invention to treat, use white bottle A medicinal liquid the morning, 1000 1 bottle of chickens (500ml/ bottle), concentrate drinking-water; Using palm fibre bottle B medicinal liquid afternoon, is also 1 bottle of 1000 chicken (500ml/ bottles), concentrates drinking-water to use, be used in conjunction 4 days after chicken group death stop, spirit, appetite recover normal.
Claims (2)
1. a herbal medicine oral liquid of preventing and treating poultry virus disease, is characterized in that: by A medicinal liquid and B medicinal liquid, formed,
Its active component of A medicinal liquid is made by the raw material of following parts by weight:
16～24 parts of the Radixs Astragali, 16～24 parts of Semen Raphanis, 8～12 parts of the Radix Paeoniae Albas, 8～12 parts of Radix Sanguisorbaes, 8～12 parts of Herba Epimedii, 8～12 parts of Radix Bupleuri, 8～12 parts of Fructus Aurantiis, 8～12 parts, Radix Glycyrrhizae;
Its active component of B medicinal liquid is made by the raw material of following parts by weight:
12～18 parts of Rhizoma Coptidis, 12～18 parts of Radix Et Rhizoma Rhei, 12～18 parts of Rhizoma Polygoni Cuspidati, 12～18 parts of Rhizoma Osmundae, 12～18 parts of Flos Loniceraes, 10～15 parts of Fructus Forsythiaes, 10～15 parts of Herba Houttuyniae.
2. the herbal medicine oral liquid of control poultry virus disease according to claim 1, is characterized in that: by A medicinal liquid and B medicinal liquid, formed,
Its active component of A medicinal liquid is made by the raw material of following parts by weight:
20 parts of the Radixs Astragali, 20 parts of Semen Raphanis, 10 parts of the Radix Paeoniae Albas, 10 parts of Radix Sanguisorbaes, 10 parts of Herba Epimedii, 10 parts of Radix Bupleuri, 10 parts of Fructus Aurantiis, 10 parts, Radix Glycyrrhizae;
Its active component of B medicinal liquid is made by the raw material of following parts by weight:
15 parts of Rhizoma Coptidis, 15 parts of Radix Et Rhizoma Rhei, 15 parts of Rhizoma Polygoni Cuspidati, 15 parts of Rhizoma Osmundae, 15 parts of Flos Loniceraes, 12 parts of Fructus Forsythiaes, 12 parts of Herba Houttuyniae.
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| CN104435626A (en) * | 2014-12-17 | 2015-03-25 | 鼎正动物药业（天津）有限公司 | Traditional Chinese medicine oral liquid for treating viral diseases of livestock and poultry and preparation method of traditional Chinese medicine oral liquid |
| CN105535702A (en) * | 2016-01-19 | 2016-05-04 | 肖华 | Traditional Chinese medicine composition for preventing and treating newcastle disease and preparation method thereof |
| CN106215009A (en) * | 2016-08-26 | 2016-12-14 | 任英明 | A kind of herbal medicine treating swine fever |
| CN107468796A (en) * | 2017-08-22 | 2017-12-15 | 武汉新联大生物有限公司 | A kind of clearing heat and detoxicating antiviral veterinary Chinese medicinal composition and preparation method |
| CN111011596A (en) * | 2019-11-25 | 2020-04-17 | 徐州绿科农牧科技有限公司 | Traditional Chinese medicine composition for replacing preventive antibiotics in meat duck breeding and application thereof |
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