CN1180806C - Pure Chinese medicine preparation - Google Patents
Pure Chinese medicine preparation Download PDFInfo
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- CN1180806C CN1180806C CNB011297832A CN01129783A CN1180806C CN 1180806 C CN1180806 C CN 1180806C CN B011297832 A CNB011297832 A CN B011297832A CN 01129783 A CN01129783 A CN 01129783A CN 1180806 C CN1180806 C CN 1180806C
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Abstract
The present invention provides a pure traditional Chinese medicine preparation and a preparing method thereof. The preparation is used for preventing and treating main virus disease (ND/IBD) of a chicken, and simultaneously can be used for feed supplement products for disease prevention and growth promotion. The prescription is prepared from astragali root, isatis root, heartleaf houttuynia herb, Chinese pulsatilla root, coptis, rehmannia root, indigowoad leaf, largehead atractylodes rhizome and liquorice. The pure traditional Chinese medicine preparation can be mixed with water or feed for a chicken group conveniently, can have obvious treating effect on virus diseases, such as IBD, ND, etc. of a chicken, can obviously add the weight of a chick, and is a good feed supplement having the advantages of disease resistance, growth promotion and no residue.
Description
The present invention relates to a kind of Chinese medicine preparation of preventing and treating virosiss such as infectious bursal disease, newcastle disease and preparation method thereof.
Infectious bursal disease (IBD) and newcastle (ND) are acute, contagious disease, have characteristics such as bamboo telegraph and high incidence, high mortality, are two big eqpidemic diseases of serious harm poultry husbandry.Over nearly twenties years, China fowl diseases worker has carried out going deep into systematic research to the control of IBD and ND, especially the achievement at aspects such as vaccine research, immune programme for children, immunization method and immunologic surveillances is comparatively outstanding, and be widely used, make the outbreak of epidemic of IBD and ND obtain obvious control.But because the proportion that China casual household raises chickens is very big, feeding environment is viral severe contamination, management level are very limited, immune programme for children and immunization method confusion, and the variation of virus virulence/strain, the chicken group who causes inoculating vaccine still happens occasionally and at new characteristics such as the atypical newcastle disease of aspects such as symptom, pathological changes, M ﹠ M performance; IBD is all the more so, and China has confirmed the existence of virus subtype and highly virulent strain, and this brings great difficulty for correct suitable vaccine and the rational immune programme for children of arrangement selected, and the selection of vaccine and the phenomenon that immuning failure appears in improper use usually occur.In view of this, study practicable method, be used to prevent and treat IBD and ND, its important realistic meaning is arranged.
In recent years, done number of research projects and obtained gratifying achievement aspect the livestock and poultry of China veterinary work person under herbal control intensive culture condition, studies confirm that Chinese herbal medicine has original advantage in some poultry infectious disease aspect preventing and treating, and significantly is better than chemical synthetic drug to some viral diseases; Cooperate chemical medicine to prevent and treat bacterial disease, can reduce the use amount of chemical medicine, thereby alleviate the toxic and side effects of chemicals and intravital residual, delay the appearance of Resistant strain, have crucial public health meaning poultry.People such as Yang Yucheng are that prescription is succeeded in developing " virus gram " with Flos Lonicerae, Radix Isatidis, the Radix Astragali, Radix Scrophulariae, Radix Angelicae Sinensis, Rhizoma Atractylodis, are used for the control of virosis, it is reported that the cure rate to artificial challenge ND and IBD reaches 63.16% and 93.33% respectively; People such as Guo Guiqiang, Jiang Wencan has also developed the control that preparations such as " fowl plague life treasured ", " spirit of gram pestilence " are used for atypical newcastle disease.But above-mentioned these Chinese medicine preparation of developing all can only not have the function that promotes the chicken growth as the drug use of the main diseases viral disease (ND/IBD) of preventing and treating chicken, and purposes is single, the demand that incompatibility is raised chickens and produced.
The purpose of this invention is to provide a kind of main diseases viral disease (ND/IBD) that both can be used to prevent and treat chicken, can be used for the product of diseases prevention, somatotrophic feed additive simultaneously again---a kind of Chinese medicine preparation (being called for short " Kangnangyi ") of preventing and treating infectious bursal disease, newcastle disease and preparation method thereof.To adapt to the actual demand of raising chickens and producing.
For realizing purpose of the present invention, we are at the Chinese medicine antiviral, on the basis of Chinese medicine growth promotion two aspect research achievements, study, explore, develop and both have control ND/IBD function, again the combination formula of the pure Chinese medicinal preparation " Kangnangyi " that can use as the feed additive of raising chickens in producing.The prescription of said preparation is as follows: Radix Astragali 4-8 part, Radix Isatidis 4-8 part, Herba Houttuyniae 2-6 part, Radix Pulsatillae 2-6 part, Rhizoma Coptidis 1-5 part, Radix Rehmanniae 1-5 part, Folium Isatidis 1-5 part, Rhizoma Atractylodis Macrocephalae 1-5 part, Radix Glycyrrhizae 1-3 part (weight portion).
The preparation method of this pure Chinese medicinal preparation " Kangnangyi " comprises following technical process:
(1) Radix Astragali is used cold distilled water (4 ℃ of water temperatures) merceration 36 hours, collects the doubling dose that immersion is concentrated into crude drug weight;
(2) Radix Isatidis, the Radix Pulsatillae, Herba Houttuyniae are collected the doubling dose that immersion is concentrated into crude drug weight with 45% ethanol hot dipping 48 hours;
(3) Radix Glycyrrhizae is used the ammonia percolation, and percolate is concentrated into the doubling dose of crude drug weight;
(4) Rhizoma Coptidis, Folium Isatidis, the Radix Rehmanniae, the Rhizoma Atractylodis Macrocephalae mix above-mentioned medicinal residues water logging 30 minutes, and heating decocts, and at a simmer with high heat before, change slow fire into after boiling, and keep slight boiling condition 1 hour, leach medicinal liquid, and the squeezing medicinal residues fully extrude medicinal liquid;
(5) merge whole medicinal liquids, be evaporated to the twice of the whole crude drug amount of prescription weight;
(6) ethanol (concentration is 70%) of adding 10%, 0.1% sodium benzoate is anticorrosion, packing.
This Chinese medicine preparation " Kangnangyi " is based on principle such as traditional Chinese veterinary medicine " set upright hold concurrently eliminating evil " and develops in conjunction with the characteristics of incidence of chicken IBD/ND and chicken growth characteristic, and its principles of formulating prescriptions are invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, strengthening vital QI to eliminate pathogenic factors.
Its side separates as follows:
It is depressed to cure mainly chicken essence god, inappetence, and fervescence, it is thin to defecate, and it is stupid to stand, and is reluctant to walk about, and human body is become thin.The Radix Astragali, Rhizoma Atractylodis Macrocephalae warming and invigorating the spleen and stomach, invigorating the spleen and replenishing QI, living positive consolidating superficial resistance are principal agent in the side, Rhizoma Coptidis, the Radix Rehmanniae, the Radix Pulsatillae, Radix Isatidis heat-clearing and toxic substances removing are accessory drugs, Radix Glycyrrhizae invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, the mitigation property of medicine are adjuvant drug, and all medicines are harmonious and reach the effect of invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing.In addition, can use, have effects such as the growth of promotion, enhancing body premunition as feed additive.
The quality standard of product of the present invention is:
This product is a sepia, slightly muddy solution; Gas perfume (or spice), bitter in the mouth, little suffering; Relative density should be not less than 1.08; PH value is between 3.5-5.0; Contain crude drug amount 0.5g ± 0.05g/ml.
Pure Chinese medicinal preparation of the present invention " Kangnangyi " was done following efficacy test:
The effect observation of 1 " Kangnangyi " control chicken IBD
Under laboratory condition, carried out " Kangnangyi " control test to chicken IBD, the result of the test of preventing and treating to IBD is: 1 day in advance to chicken drink-service " Kangnangyi ", dosage is 1ml//day, logotype 5 days, the counteracting toxic substances Effective Vate of Protection reaches 86.67% and relatively extremely significantly (t check: p＜0.01) of (counteracting toxic substances matched group chicken survival rate is 66.67%) difference of matched group; Behind the counteracting toxic substances 4 hours, begin to chicken drink-service " Kangnangyi ", dosage be 1ml/ only/day, logotype 5 days, Effective Vate of Protection is 83.33% and significantly (the t check: p＜0.01) of the poor heteropole of matched group; 2 days begin to chicken drink-service " Kangnangyi " behind the counteracting toxic substances, dosage be 1ml/ only/day, logotype 5 days, Effective Vate of Protection is 76.67% and significantly (the t check: p＜0.05) of matched group comparing difference; Increase " Kangnangyi " using dosage to 2ml//day, 5 days test group of logotype, the counteracting toxic substances Effective Vate of Protection does not have obvious raising.Show that thus application " Kangnangyi " control IBD has good prevention effect, should begin administration time as early as possible for improving curative effect, using dosage is with 1ml//day, and logotype was advisable in 5 days.
The effect observation of 2 " Kangnangyis " control chicken ND
With the fast big broiler of the yellow plumage of the non-immunity of 30 ages in days is subjects, carries out artificial counteracting toxic substances with median lethal dose(LD 50) ND intensity, observes " Kangnangyi " prevention effect to ND.The result shows: preceding 1 day of counteracting toxic substances, begin to chicken feed drink " Kangnangyi " 1ml/ only/day, logotype 5 days, the counteracting toxic substances Effective Vate of Protection reach 73.3% and matched group relatively (counteracting toxic substances matched group chicken survival rate is 56.7%; ) significant difference (t check: p＜0.05); Using ND IV is that vaccine immunity cooperates Kangnangyi drinking-water simultaneously, and the counteracting toxic substances Effective Vate of Protection reaches 83.3% and significantly (the t check: p＜0.01) of the poor heteropole of matched group after 3 days; The chicken group occurs beginning to feed drink " Kangnangyi " 2ml//day to chicken after the symptom, logotype 5 days, and the treatment effective percentage reaches 66.7%.If cooperate intramuscular injection cephalosporin simultaneously, can improve the treatment effective percentage and reach 73.3%.Simple result of the test explanation is used when ND is given birth in the chicken mass-sending in the urgent immunity of weak malicious Seedling, uses " Kangnangyi " can accelerate chicken group rehabilitation to chicken drinking-water, reduces the chicken death toll.When using " Kangnangyi " processing ND case, some antibiotic can be suitably be used in addition, the chicken death toll can be reduced to a certain extent to prevent chicken group's secondary infection.
3 " Kangnangyis " are to the influence of chicken growth promoter and immune organ
With 60 10 day age chickling be divided into 3 groups at random, 20 every group.The I group is for measuring the test group that influences to growth promoter, and the II group is for measuring the test group that influences to immune organ, and the III group is the normal control group.I, II test group from 10 day age except that normal raising, add in the drinking-water " Kangnangyi " 0.5ml/ only/day, logotype 5 days stopped 5 days, reuse 5 days.Finished test to 20 day age, add up each test value, show that significantly (the t check: p＜0.01), " Kangnangyi " test II group Fa Shi refers to significantly (the t check: p＜0.05) of capsule number (%) spleen index (%) and control Group II I comparing difference for " Kangnangyi " test I group average weight gain, average feed consumption, material anharmonic ratio and the poor heteropole of control Group II I; The result: " Kangnangyi " has the chicken of quickening growth rate, improves efficiency of feed utilization, the effect of enhancing body resistance.
The observation of curative effect on probation of 4 " Kangnangyis "
At the test site Chinese medicine preparation " Kangnangyi " is tried out observe the curative effect.Use " Kangnangyi " plumage more than 1.2 hundred million part altogether, about 65% is used for the control of chicken IBD, and 25% is applied to the control of newcastle disease, and other auxiliary treatment that is applied to diseases such as Columba livia I type paramyxovirus disease, bird flu reaches the use as additive.
The trial effect of " 4.1 Kangnangyi " control IBD
Promptly adopt " Kangnangyi " to chicken drinking-water in early days in chicken mass-sending disease, the 1st day 2ml/ only, 2-5 days 1ml/ only/day, generally saw promptly on the 2nd day in medication that the chicken group mental status was clearly better, dead chicken number reduces, and chicken group foodstuff amount is recovered gradually, stops death substantially to 3-4 days chicken group chickens.The mortality rate multipotency is controlled at about 1%, and effective percentage reaches more than 98% and (the t check: p＞0.05) of the yellow no significant difference of injection high-immunity egg.Infect serious chicken group at some, because of chicken body constitution poor, as intramuscular injection high-immunity egg Huang often cause more serious stress, the rate that causes death increases, and uses " Kangnangyi " treatment this moment, can obviously reduce chicken death, therapeutic effect significantly is better than intramuscular injection high-immunity egg Huang.Use " Kangnangyi " whole therapeutic process drug cost at 0.08-0.1 unit/plumage, in the production of raising chickens, can accept.
" 4.2 Kangnangyi " control chicken ND trial effect
ND is given birth in chicken mass-sending at present, and adopting ND I usually is that vaccine is given promptly immunity of chicken, this processing way, and the chicken group generally will just can stop death about 4-5 days.Observing 5 morbidity chicken groups, to use ND I be vaccine when giving the urgent immunity of chicken, begin to chicken drink-service " Kangnangyi ", the 1st day 2ml/ only, 2-5 days 1ml/ only/day.Medication saw promptly on the 2nd day that the chicken group mental status was clearly better, and dead chicken number obviously reduced or stopped death in the 3rd day, and effective percentage is more than 85%.Be applied to take place the chicken group of subclinical type ND aborning, use " Kangnangyi " generally at the 2nd day of the beginning medicine feed separately, the chicken death toll promptly obviously reduces, and it is normal that the chicken group recovers gradually.
4.3 to a plurality of generation Columba livia I type paramyxovirus disease Columba livia groups being arranged when using the urgent immunity of Columba livia I type paramyxovirus inactivated vaccine, using " Kangnangyi " drinks water to Columba livia, show " Kangnangyi " mental status, and the body constitution of sick Columba livia recovers to have obvious facilitation to sick Columba livia group.
4.4 to part chicken group from 1 day age chickling bring into use " Kangnangyi " drinking-water (0.1ml/ only/day) to 20 day age, confirmation can obviously promote the growth of chicken, reduce death rate.
Show that according to test pure Chinese medicinal preparation of the present invention " Kangnangyi " has following major technique effect:
1, " Kangnangyi " is Chinese herbal and crude drugs preparations, mixes water or spice use can for the chicken group, and be convenient, effectively, overcome the problem that injection high-immunity egg yellow liquor may bring.In addition, Chinese herbal medicine is that crude drug is a Chinese herbal and crude drugs preparations, mixes water or spice use can for the chicken group, and is convenient, effectively, thing, little to the side effect of animal body, residual low, aspect public health, have remarkable advantages.Therefore, the research and development of " Kangnangyi " has obvious practical significance.
2, " Kangnangyi " reaches as high as 86.67% to the counteracting toxic substances protective rate of IBD, and the on-scene care effective percentage reaches 98%; To the counteracting toxic substances protective rate of ND reach as high as 73.3% and counteracting toxic substances matched group comparing difference remarkable, have tangible prevention effect, on-the-spotly cooperate urgent inoculation, the control effective percentage reaches more than 85%.
3, " Kangnangyi " can obviously promote the weightening finish of chickling, is the feed additive of a kind of well disease-resistant, growth promotion, noresidue.In addition, " Kangnangyi " can improve spleen index and the fabricius bursa index of chicken, illustrates that " Kangnangyi " has the effect of enhancing human body immunity function, understands the function of virosiss such as " Kangnangyi " control IBD and ND from mechanism Shanghai Stock Exchange.
Embodiment one
The prescription of this routine pure Chinese medicinal preparation " Kangnangyi " is: 4 parts of the Radixs Astragali, 6 parts of Radix Isatidis, 6 parts of Herba Houttuyniae, 3 parts of the Radix Pulsatillaes, 3 parts of Rhizoma Coptidis, 2 parts in the Radix Rehmanniae, 1 part of Folium Isatidis, 4 parts of the Rhizoma Atractylodis Macrocephalaes, 1 part in Radix Glycyrrhizae (weight portion).
Concocting method:
The Radix Astragali is used cold distilled water (4 ℃ of water temperatures) merceration 36 hours, collects the doubling dose that immersion is concentrated into crude drug weight;
Radix Isatidis, the Radix Pulsatillae, Herba Houttuyniae are collected the weight doubling dose that immersion is concentrated into crude drug with 45% ethanol hot dipping 48 hours;
Radix Glycyrrhizae is used the ammonia percolation, and percolate is concentrated into the doubling dose of crude drug weight;
Rhizoma Coptidis, Folium Isatidis, the Radix Rehmanniae, the Rhizoma Atractylodis Macrocephalae mix above-mentioned medicinal residues water logging 30 minutes, and heating decocts, and at a simmer with high heat before, change slow fire into after boiling, and keep slight boiling condition 1 hour, leach medicinal liquid, and the squeezing medicinal residues fully extrude medicinal liquid;
Merge whole medicinal liquids, be evaporated to the twice of the whole crude drug amount of prescription weight;
The ethanol (concentration is 70%) of adding 10%, 0.1% sodium benzoate is anticorrosion, packing.
Embodiment two
The prescription of this routine pure Chinese medicinal preparation " Kangnangyi " is: 6 parts of the Radixs Astragali, Radix Isatidis 4-part, 4 parts of Herba Houttuyniae, 4 parts of the Radix Pulsatillaes, 2 parts of Rhizoma Coptidis, 2 parts in the Radix Rehmanniae, 1 part of Folium Isatidis, 6 parts of the Rhizoma Atractylodis Macrocephalaes, 1 part in Radix Glycyrrhizae (weight portion).Its concocting method is with embodiment one.
Embodiment three
The prescription of this routine pure Chinese medicinal preparation " Kangnangyi " is: 7 parts of the Radixs Astragali, 7 parts of Radix Isatidis, 2 parts of Herba Houttuyniae, 2 parts of the Radix Pulsatillaes, 4 parts of Rhizoma Coptidis, 3 parts in the Radix Rehmanniae, 2 parts of Folium Isatidiss, 1 part of the Rhizoma Atractylodis Macrocephalae, 2 parts in Radix Glycyrrhizae (weight portion).Its concocting method together
Embodiment one.
Claims (2)
1. Chinese medicine preparation of preventing and treating infectious bursal disease, newcastle disease is characterized in that it is made by following raw medicaments in portion by weight: Radix Astragali 4-8 part, Radix Isatidis 4-8 part, Herba Houttuyniae 2-6 part, Radix Pulsatillae 2-6 part, Rhizoma Coptidis 1-5 part, Radix Rehmanniae 1-5 part, Folium Isatidis 1-5 part, Rhizoma Atractylodis Macrocephalae 1-5 part, Radix Glycyrrhizae 1-3 part.
2. the preparation method of the Chinese medicine preparation of control infectious bursal disease according to claim 1, newcastle disease is characterized in that comprising following technical process:
(1) Radix Astragali is collected the doubling dose that immersion is concentrated into crude drug weight with the cold distilled water merceration of 4 ℃ of water temperatures 36 hours;
(2) Radix Isatidis, the Radix Pulsatillae, Herba Houttuyniae are collected the doubling dose that immersion is concentrated into crude drug weight with 45% ethanol hot dipping 48 hours;
(3) Radix Glycyrrhizae is used the ammonia percolation, and percolate is concentrated into the doubling dose of crude drug weight;
(4) Rhizoma Coptidis, Folium Isatidis, the Radix Rehmanniae, the Rhizoma Atractylodis Macrocephalae mix above-mentioned medicinal residues water logging 30 minutes, and heating decocts, and at a simmer with high heat before, change slow fire into after boiling, and keep slight boiling condition 1 hour, leach medicinal liquid, and the squeezing medicinal residues fully extrude medicinal liquid;
(5) merge whole medicinal liquids, be evaporated to the twice of the whole crude drug amount of prescription weight;
(6) adding 10% concentration is 70% ethanol, and 0.1% sodium benzoate is anticorrosion, packing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011297832A CN1180806C (en) | 2001-10-18 | 2001-10-18 | Pure Chinese medicine preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011297832A CN1180806C (en) | 2001-10-18 | 2001-10-18 | Pure Chinese medicine preparation |
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| CN1411833A CN1411833A (en) | 2003-04-23 |
| CN1180806C true CN1180806C (en) | 2004-12-22 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB011297832A Expired - Fee Related CN1180806C (en) | 2001-10-18 | 2001-10-18 | Pure Chinese medicine preparation |
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Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100438902C (en) * | 2006-07-05 | 2008-12-03 | 河北农业大学 | Medicine for preventing and treating infectious rhinitis of chicken |
| CN102188536A (en) * | 2010-03-12 | 2011-09-21 | 关中生 | Method for preparing Radix Astragali rehmanniae radix particles |
| CN101912452A (en) * | 2010-08-31 | 2010-12-15 | 四川华神农大动物保健药品有限公司 | Veterinary Chinese medicinal composition for enhancing nonspecific immunologic function and application thereof |
| CN102524576B (en) * | 2012-01-11 | 2013-07-24 | 陵县世海养殖专业合作社 | Chicken feed and preparation method |
| CN102552657B (en) * | 2012-02-06 | 2013-09-25 | 青岛农业大学 | Chinese medicinal composition used for treating Newcastle disease of chicken |
| CN105168357A (en) * | 2015-09-10 | 2015-12-23 | 重庆布尔动物药业有限公司 | Effect of stephania terandra and radix astragali oral liquor on common infectious diseases serum antibody titers of chicken |
| CN107982343A (en) * | 2017-11-17 | 2018-05-04 | 锦州景良动物药业有限公司 | A kind of preparation method of the traditional Chinese medicine oral liquid of chick epidemic prevention |
| CN112022924A (en) * | 2020-10-22 | 2020-12-04 | 河南大农联生物工程有限公司 | Traditional Chinese medicine composition for preventing and treating pigeon pest and preparation method thereof |
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2001
- 2001-10-18 CN CNB011297832A patent/CN1180806C/en not_active Expired - Fee Related
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