CN106214862A - A kind of Traditional Chinese veterinary medicine oral solution preventing and treating the atypical newcastle of chicken and preparation method thereof - Google Patents
A kind of Traditional Chinese veterinary medicine oral solution preventing and treating the atypical newcastle of chicken and preparation method thereof Download PDFInfo
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- CN106214862A CN106214862A CN201610695005.XA CN201610695005A CN106214862A CN 106214862 A CN106214862 A CN 106214862A CN 201610695005 A CN201610695005 A CN 201610695005A CN 106214862 A CN106214862 A CN 106214862A
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- Oil, Petroleum & Natural Gas (AREA)
- Neurosurgery (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to field of traditional Chinese veterinary, particularly disclose a kind of Traditional Chinese veterinary medicine oral solution preventing and treating the atypical newcastle of chicken and preparation method thereof.The Traditional Chinese veterinary medicine oral solution of this atypical newcastle of preventing and treating chicken is with Herba Agrimoniae, Herba Lysimachiae, Radix Isatidis, the Radix Astragali, Rhizoma Polygoni Cuspidati, Rhizoma Osmundae, Radix Scutellariae, Radix Ampelopsis, Radix Glycyrrhizae as active component, make by certain parts by weight, it is specifically designed to the preventing and treating chronic newcastle of chicken, evident in efficacy, can drink water medication, poultry medication is convenient, and degree of absorbing is high, drug residue free, to ensureing that the cultivation of poultry green health is significant.
Description
Technical field
The invention belongs to field of traditional Chinese veterinary, particularly to a kind of Traditional Chinese veterinary medicine oral solution preventing and treating the atypical newcastle of chicken and
Its preparation method.
Background technology
Newcastle (ND) is that the one of the fowl caused by Avian pneumo-encephalitis virus is acute, hot, septic and high degree in contact pass
Catching an illness, disease is with high heat, dyspnea, dysentery, neurological disorders, mucosa and serous coat is hemorrhage is characterized, and has the highest sickness rate
And case fatality rate, it is a kind of Infectious Diseases of harm aviculture.Along with commonly using of vaccine, the typical newcastle of high mortality
The most less generation, but with sickness rate 10%-30%, clinical symptoms is inconspicuous, pathological change is not true to type, mortality rate is the highest, lay eggs
The atypical newcastle disease that chicken egg drop reduction is characterized occurs the most repeatedly, and provisions fowl industry brings huge economic loss.
Newcastle mainly uses vaccine immunity to prevent, and chicken group once fall ill, and there is no specific treatment medicine, particularly exists
The antiviral Western medicine such as amantadine, ribavirin disables after poultry in China, and the treatment of newcastle has become more prominent
A difficult problem.Chinese herbal medicine is a big treasure-house of China's traditional medicine, has the feature of Yin Yang balancing, eliminating pathogenic factor for supporting vital QI, treating both the principal and secondary aspects of a disease, positive day
Benefit becomes the focus of new antiviral drug research.Because of Chinese medicine have that effect is unique, antiviral spectrum is wide, toxic and side effects is little, evident in efficacy
Etc. advantage, herbal medicine as prevention, treatment disease and is promoted that the emphasis of growth of animal makes by many large-scale livestock and poultry cultivation enterprises
With object, the herbal medicine of middle-size and small-size plant (family) uses the most increasingly extensive.Along with improving constantly of living standards of the people, China
People's diet structure there occurs significantly change, and green products of domestic animal is favored by market deeply.Poultry is solved by herbal control
Western medicine residue problem in poultry product, produces nontoxic, harmless animal products, becomes the inexorable trend of following animal husbandry development.
Therefore, need a kind of Chinese herbal medicine badly and prevent and treat diseases caused by exogenous pathogenic factor epidemic disease according to determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs principle and the atypical newcastle disease that causes.
Summary of the invention
The technical problem to be solved in the present invention be to provide one prepare composition proportion simple, each rationally, good effect, without medicine
Residual, poultry is prone to absorption, the Traditional Chinese veterinary medicine oral solution of the preventing and treating atypical newcastle of chicken easy to use and preparation method thereof.
The technical scheme is that
A kind of Traditional Chinese veterinary medicine oral solution preventing and treating the atypical newcastle of chicken, its active component is by the raw material of following parts by weight
Make: Herba Agrimoniae 10～30 parts, Herba Lysimachiae 12～36 parts, Radix Isatidis 10～30 parts, the Radix Astragali 7～21 parts, Rhizoma Polygoni Cuspidati 10～30 parts, pass through
Many 18～24 parts, Radix Scutellariae 18～24 parts, Radix Ampelopsis 7～21 parts, Radix Glycyrrhizae 3～9 parts.
The Traditional Chinese veterinary medicine oral solution of this atypical newcastle of preventing and treating chicken, the weight proportion of its preferred each raw material is: red crowned crane
Grass 20 parts, Herba Lysimachiae 24 parts, Radix Isatidis 20 parts, the Radix Astragali 14 parts, Rhizoma Polygoni Cuspidati 20 parts, Rhizoma Osmundae 21 parts, Radix Scutellariae 21 parts, Radix Ampelopsis 14 parts, sweet
Grass 6 parts.
The preparation method of the Traditional Chinese veterinary medicine oral solution of this atypical newcastle of preventing and treating chicken, employing following steps:
(1) each raw material mixing weighing above-mentioned parts by weight is placed in Chinese medicine extracting tank, boiling 2 times, specifically side
Method is: adds the water of 7 times of weight for the first time, soaks 1 hour, boil 1 hour, obtains first-time filtrate after filtration；Second time adds 3 times of weight
Water, boil 0.5 hour, after filtration secondary filtrate；
(2) first-time filtrate prepared in combining step (1) and secondary filtrate, obtain merging filtrate；Merging filtrate is reduced pressure dense
It is reduced to every milliliter of concentrated solution and is equivalent to 1g crude drug, obtain concentrated solution；
(3) in concentrated solution step (2) prepared, addition accounts for the sodium benzoate that concentrated solution weight ratio is 0.3%, and stirring is all
Even, obtain the Traditional Chinese veterinary medicine oral solution of the described preventing and treating atypical newcastle of chicken.
Usage and dosage: every day 1ml/kg body weight, drinking-water, be used in conjunction 4-5 days.
The property of medicine and the pharmacology analysis of raw material of Chinese medicine selected by the present invention are as follows:
Rhizoma Polygoni Cuspidati: mildly bitter flavor, cold nature.Enter liver, gallbladder, lung three warp.There is dampness removing jaundice eliminating, heat-clearing and toxic substances removing, eliminating stasis to stop pain, cough-relieving
The merit reduced phlegm.Curing mainly jaundice due to damp-heat, stranguria with turbid discharge, leukorrhagia, rheumatic arthralgia, carbuncle sore tumefacting virus, burn due to hot liquid or fire, amenorrhea, lump in the abdomen, instep beats damage
Wound, cough due to lung-heat.
Herba Agrimoniae: bitter in the mouth, puckery, property is put down.Enter the heart, liver two warp.There is astringing to arrest bleeding, detoxification sore treatment, parasite killing, puckery antiperspirant, cough-relieving
Merit.Cure mainly spitting of blood, spit blood, epistaxis, hematuria, metrorrhagia, dysentery, malaria, diabetes hyperhidrosis, the disease such as overstrain cough, external treatment infusorian
The property disease such as vaginitis, furuncle carbuncle, hemorrhoid.
Radix Isatidis: bitter in the mouth, cold in nature.Enter the heart, stomach two warp.There is heat-clearing and toxic substances removing, removing heat from blood, the merit of sore-throat relieving.Cure mainly pestilence seasonal noxious pathogen,
Heating pharyngalgia, maculae caused by violent heat pathogen, mumps, scarlet fever, major part pestilence, erysipelas, carbuncle.
Herba Lysimachiae: sweet in the mouth, salty, cold nature.Enter liver, gallbladder, kidney, bladder four warp.There is relieving stranguria by diuresis, heat-clearing and toxic substances removing, dissipating blood stasis
Detumescence, eliminating damp-heat, Sha Lin, urinate and puckery have a pain, jaundice dark coloured urine, the merit of carbuncle furuncle.Cure mainly liver and gall and urinary system calculus, pyretic stranguria,
Oedema due to nephritis, jaundice due to damp-heat, sore carbuncle, venom, traumatic injury.
The Radix Astragali: sweet in the mouth, slightly warm in nature.Enter spleen, lung two warp.There is polishing consolidating superficial resistance, the merit of torr skin ulcer granulation promoting.Cure mainly body void spontaneous perspiration,
Chronic diarrhea, proctoptosis, uterine prolapse, chronic nephritis, body is impractical swollen, chronic ulcer, the long disunion of the open sore part.
Rhizoma Osmundae: bitter in the mouth, is slightly cold.Return liver, spleen channel.There is parasite killing, heat clearing away, removing toxic substances, the merit of cooling blood for hemostasis.Cure mainly wind heat sense
Emit, warm skin eruption, spit blood, hemoptysis, epistaxis, have blood in stool, metrorrhagia, dysentery, the intestinal parasitic disease such as leukorrhagia and hook, ascarid, cestode.
Radix Scutellariae: bitter in the mouth, cold in nature, enters the heart, lung, gallbladder, large intestine channel.There is removing the relative excess fire, dehumidifying heat, hemostasis, antiabortive merit.Cure mainly
High fever excessive thirst, cough due to lung-heat, damp-heat dysentery, jaundice, pyretic stranguria, tell, be defeated in battle, collapse, leak, conjunctival congestion and swelling pain, frequent fetal movement, carbuncle furuncle.
Radix Ampelopsis: bitter in the mouth, pungent, cold nature.Enter the heart, lung, liver, spleen four warp.There is heat-clearing and toxic substances removing, removing obstruction for relieving pain, promoting tissue regeneration and ulcer healing
Merit.Treatment of ulcer toxic swelling, scrofula, scald, eczema, pyrexial malaria, infantile convulsion, dysentery, hemorrhoidal hamorrhage, anal fistula, leucorrhea, traumatic injury, wound
Hemorrhage.
Radix Glycyrrhizae: sweet in the mouth, property is put down.Enter the heart, lung, spleen, stomach four warp.Have and middle emergency, lung moistening, removing toxic substances, the merit of coordinating the actions of various ingredients in a prescription.
Curing mainly weakness of the spleen and stomach, lack of appetite, loose stool of suffering from abdominal pain, overstrain generates heat, and consumptive lung disease is coughed, cardiopalmus, infantile convulsion；Raw use, controls laryngopharynx swelling and pain, digestibility
Ulcer, ulcer sores, solve poison of drug and alimentary toxicosis.
The present invention prevents and treats Traditional Chinese veterinary medicine oral solution of the atypical newcastle of chicken and preparation method thereof, for the physiological situation of chicken
And health status, by plurality of raw materials mix and match, scientific composition, wherein Rhizoma Polygoni Cuspidati, Radix Scutellariae heat-clearing and toxic substances removing are principal agent, Herba Agrimoniae, plate
Lan Gen, Rhizoma Osmundae, Radix Ampelopsis, Herba Lysimachiae cooling blood for hemostasis, removing obstruction for relieving pain, eliminating damp-heat are ministerial drug, and it is assistant that Radix Astragali benefit defends consolidating superficial resistance, and Radix Glycyrrhizae is adjusted
With all medicines for making.Each raw material is had complementary advantages, and utilizes the collaborative or resistant function that it is mutual, has heat-clearing and toxic substances removing, dampness removing heat from blood
Effect, can be used for the preventing and treating of the atypical newcastle of chicken, good effect, no drug residue.
Detailed description of the invention
In order to make technical scheme clearer, below in conjunction with embodiment, the present invention is carried out further
Describe in detail.
Embodiment 1:
The Traditional Chinese veterinary medicine oral solution of this atypical newcastle of preventing and treating chicken, is made up of the raw material of following weight:
Herba Agrimoniae 20 kilograms, Herba Lysimachiae 24 kilograms, Radix Isatidis 20 kilograms, the Radix Astragali 14 kilograms, Rhizoma Polygoni Cuspidati 20 kilograms, Rhizoma Osmundae 21,000
Gram, Radix Scutellariae 21 kilograms, Radix Ampelopsis 14 kilograms, 6 kilograms of Radix Glycyrrhizae；
The preparation method of the Traditional Chinese veterinary medicine oral solution of this atypical newcastle of preventing and treating chicken, employing following steps:
(1) weigh each raw material (160 kilograms altogether) of above-mentioned weight, put in Chinese medicine extracting tank after mixing, add Chinese medicine
The water (i.e. 1120 kilograms) that raw material weight is 7 times, soaks 1 hour, decocts, and keeps 1 hour, tapping, filter once to filter after boiling
Liquid；Medicinal residues add the water (i.e. 480 kilograms) of raw material of Chinese medicine weight 3 times, decoct, and keep 0.5 hour, tapping after boiling, and filter
Obtain secondary filtrate；
(2) first-time filtrate prepared in combining step (1) and secondary filtrate, obtain merging filtrate, be placed in efficient concentration device
Concentrating under reduced pressure, concentration of liquid medicine is equivalent to 1g crude drug (i.e. 160 liters) to every milliliter of concentrated solution, obtains concentrated solution；
(3) in concentrated solution step (2) prepared, addition accounts for the sodium benzoate anticorrosion that concentrated solution weight ratio is 0.3%, stirs
With 250ml plastic drug package fill after mixing uniformly, obtain the Traditional Chinese veterinary medicine oral solution of the described preventing and treating atypical newcastle of chicken.
Usage and dosage: every day 1ml/kg body weight, drinking-water, be used in conjunction 4-5 days.
Embodiment 2:
The Traditional Chinese veterinary medicine oral solution of this atypical newcastle of preventing and treating chicken, is made up of the raw material of following weight: Herba Agrimoniae 30,000
Gram, Herba Lysimachiae 36 kilograms, Radix Isatidis 30 kilograms, the Radix Astragali 21 kilograms, Rhizoma Polygoni Cuspidati 30 kilograms, Rhizoma Osmundae 24 kilograms, Radix Scutellariae 24 kilograms, Radix Ampelopsis
21 kilograms, 9 kilograms of Radix Glycyrrhizae；
Preparation method and usage and dosage are with embodiment 1.
Embodiment 3:
The Traditional Chinese veterinary medicine oral solution of this atypical newcastle of preventing and treating chicken, is made up of the raw material of following weight: Herba Agrimoniae 10,000
Gram, Herba Lysimachiae 12 kilograms, Radix Isatidis 10 kilograms, the Radix Astragali 7 kilograms, Rhizoma Polygoni Cuspidati 10 kilograms, Rhizoma Osmundae 18 kilograms, Radix Scutellariae 18 kilograms, Radix Ampelopsis 7
Kilogram, 3 kilograms of Radix Glycyrrhizae；
Preparation method and usage and dosage are with embodiment 1.
Embodiment 4:
The Traditional Chinese veterinary medicine oral solution of this atypical newcastle of preventing and treating chicken, is made up of the raw material of following weight: Herba Agrimoniae 15,000
Gram, Herba Lysimachiae 18 kilograms, Radix Isatidis 15 kilograms, the Radix Astragali 10.5 kilograms, Rhizoma Polygoni Cuspidati 15 kilograms, Rhizoma Osmundae 19.5 kilograms, Radix Scutellariae 19.5 thousand
Gram, Radix Ampelopsis 10.5 kilograms, 4.5 kilograms of Radix Glycyrrhizae；
Preparation method and usage and dosage are with embodiment 1.
Embodiment 5:
The Traditional Chinese veterinary medicine oral solution of this atypical newcastle of preventing and treating chicken, is made up of the raw material of following weight: Herba Agrimoniae 25,000
Gram, Herba Lysimachiae 30 kilograms, Radix Isatidis 25 kilograms, the Radix Astragali 17.5 kilograms, Rhizoma Polygoni Cuspidati 25 kilograms, Rhizoma Osmundae 22.5 kilograms, Radix Scutellariae 22.5 thousand
Gram, Radix Ampelopsis 17.5 kilograms, 7.5 kilograms of Radix Glycyrrhizae；
Preparation method and usage and dosage are with embodiment 1.
Test example (one):
The preventing and treating of newcastle disease virus is imitated by the Traditional Chinese veterinary medicine oral solution preventing and treating the atypical newcastle of chicken for the checking present invention
Really, of the present invention oral liquid In-vitro Inhibitory Effect to Avian pneumo-encephalitis virus (NDV) it is expanded on further below by way of test example:
1 material
Experimental animal: 11 age in days SPF Embryo Gallus domesticus.
Virus: the F48E8 strain of Avian pneumo-encephalitis virus NDV, EID50It is 10-8.36/0.1mL。
Investigational agent: oral liquid prepared by embodiment of the present invention 1-5 is as the trial drug of test example (one).
Comparison medicine: moroxydine hydrochloride, pharmacy head factory in Liaoning produces, is made into the solution for standby of 0.1% concentration with PBS.
2 methods
2.1 egg inoculation
First NDV F48E8 strain normal saline dilution is become 200EID50Virus liquid, then by embodiment of the present invention 1-5 system
The each 1mL of standby oral liquid mixes in microcentrifugal tube with equivalent NDV diluent respectively, after 37 DEG C of water-bath effect 0.5h, respectively
Inoculate 11 age in days SPF chick embryo allantoic cavities, 0.2mL/ embryo, 10 pieces/group, as test group 1-5.
Normal saline 1ml is mixed with equivalent NDV diluent, after 37 DEG C of water-bath 0.5h, inoculates the SPF Embryo Gallus domesticus urine of 11 ages in days
Blister cavities, 0.2mL/ embryo, 10 pieces/group, as positive controls.
0.1% moroxydine hydrochloride solution 1ml is mixed with equivalent NDV diluent, 37 DEG C of water-bath 0.5h, inoculate 11 ages in days
SPF chick embryo allantoic cavity, 0.2mL/ embryo, 10 pieces/group, as drug control group.
After egg inoculation is complete, puts 37 DEG C of calorstats and hatch 96h, an every 24h Embryo Gallus domesticus of inspection, discard the dead germ in 24h,
Embryo Gallus domesticus of surviving after 24h dead germ later and 96h all puts 4 DEG C of Refrigerator stores.Record chicken embryo death time and quantity.
2.2 hemagglutination test: use micro-agglutination method to carry out, measure NDV hemagglutinative titer (HA) in every piece of chick embryo allantoic liquid.
2.3 data analysiss: employing SPSS software carries out data analysis to Embryo Gallus domesticus survival rate, the hemagglutinative titer of each group, determines
Diversity between each group.
3 results
Test 1-5 group after 96 hours Embryo Gallus domesticus all survive, moroxydine hydrochloride group and positive controls Embryo Gallus domesticus are equal in 72 hours
All dead, statistical analysis shows, exist between test 1-5 group Embryo Gallus domesticus survival rate and positive controls pole significant difference (p <
0.01), and moroxydine hydrochloride group and positive control group difference are notable (p > 0.05).From the point of view of HA titre, test 1-5 group HA
Titre is 0, and positive controls is 8.6, and moroxydine hydrochloride group is 7.8, all exists the most aobvious between test 1-5 group and positive controls
Write difference (p<0.01), and moroxydine hydrochloride group and positive control group difference be not notable (p>0.05).Result of the test refers to table
1。
Table 1 test example (one) Embryo Gallus domesticus result of the test
Test shows, oral liquid of the present invention has obvious inhibitory action to NDV propagation in vitro.
Test example (two):
In order to verify that the present invention prevents and treats the interaction between each composition of Traditional Chinese veterinary medicine oral solution of the atypical newcastle of chicken,
It is expanded on further below by way of test example.
1 material
Experimental animal: 11 age in days SPF Embryo Gallus domesticus.
Virus: the F48E8 strain of Avian pneumo-encephalitis virus NDV, EID50It is 10-8.36/0.1mL。
Investigational agent: the embodiment of the present invention 1 preparation oral liquid and from 9 kinds of raw materials of the embodiment of the present invention 1 oral liquid appoint
Meaning choose one of which, two kinds, three kinds, four kinds, five kinds, six kinds, seven kinds, eight kinds make oral liquid, as test example (two)
Test group medicine.
2 methods
2.1 egg inoculation
First NDV F48E8 strain normal saline dilution is become 200EID50Virus liquid, then by test example (two) each test group
The each 1mL of medicine mixes in microcentrifugal tube with equivalent NDV diluent respectively, after 37 DEG C of water-bath effect 0.5h, inoculates 11 respectively
Age in days SPF chick embryo allantoic cavity, 0.2mL/ embryo, 10 pieces/group, as test group.
Normal saline 1ml is mixed with equivalent NDV diluent, after 37 DEG C of water-bath 0.5h, inoculates the SPF Embryo Gallus domesticus urine of 11 ages in days
Blister cavities, 0.2mL/ embryo, 10 pieces/group, as positive controls.
2.2 hemagglutination test: use micro-agglutination method to carry out, measure NDV hemagglutinative titer (HA) in every piece of chick embryo allantoic liquid.
2.3 data analysiss: employing SPSS software carries out data analysis to Embryo Gallus domesticus survival rate, the hemagglutinative titer of each group, determines
Diversity between each group.
3 results
Positive controls in 48 hours Embryo Gallus domesticus the most dead, HA titre is 8.6；Oral liquid group (the 1-1 of embodiment 1 preparation
Group), Embryo Gallus domesticus is all survived, and HA titre is 0；2-1 group is to 2-27 group, and respectively group Embryo Gallus domesticus survival rate is all between 10%～60%, HA
Titre is between 4.7～8.2.Statistical analysis shows, the oral liquid group Embryo Gallus domesticus survival rate of embodiment 1 preparation, HA titre are with positive
Pole significant difference (p < 0.01) is there is between matched group.From the point of view of result of the test, the oral liquid effect of embodiment 1 preparation is superior to it
Its each test group.
The experimental result now choosing wherein 28 groups is described as follows:
Each test group oral liquid component in table 2 test example (two)
The preparation method of test example (two) each test group medicine is as follows:
(1) weigh each raw material, put in Chinese medicine extracting tank after mixing, add the water of raw material of Chinese medicine weight 7 times, soak 1 little
Time, decoct, keep 1 hour after boiling, tapping, filter to obtain first-time filtrate；Medicinal residues add the water of raw material of Chinese medicine weight 3 times, decoct
Boil, keep 0.5 hour after boiling, tapping, filter to obtain secondary filtrate；
(2) first-time filtrate prepared in combining step (1) and secondary filtrate, obtain merging filtrate, be placed in efficient concentration device
Concentrating under reduced pressure, concentration of liquid medicine is equivalent to 1g crude drug to every milliliter of concentrated solution, obtains concentrated solution；
(3) in concentrated solution step (2) prepared, addition accounts for the sodium benzoate anticorrosion that concentrated solution weight ratio is 0.3%, stirs
With 250ml plastic drug package fill after mixing uniformly, obtain described test group oral liquid.
Table 3 test example (two) Embryo Gallus domesticus result of the test
Test shows, oral liquid of the present invention has obvious inhibitory action to NDV propagation, and drug ratio is best, hence it is evident that excellent
Medicine is respectively organized in other.
Application examples:
Case 1:
Jinan plant, only, during 230 age in days, chicken group starts to send out the blue brown laying hen more than 8000 in sea that wherein a hen house is raised
Disease, sick chicken spirit is depressed, and feed intake declines, and has respiratory symptom, draws green loose stool, and egg drop reduction, every day is the most dead.Cut open
Examine the chicken that dies of illness, glandular stomach nipple slight bleeding, muscular stomach horny layer ulcer, under horny layer, have hemorrhage speckle, whole intestinal diffusivity to go out
Blood, intestinal mucosa comes off, and cecal tonsil swelling is hemorrhage, and myocardium crown fat is hemorrhage, and trachea hyperemia is hemorrhage, and follicle is downright bad.According to
Clinical symptoms and cut open inspection pathological changes, is diagnosed as atypical newcastle.Beginning to use oral liquid of the present invention to treat, every chicken is every
It 1ml, the upper and lower noon divide 2 times concentrate drinking-water medication, be used in conjunction 5 days.After medication 3 days, chicken symptom starts to alleviate, and feed intake is notable
Increasing, after medication the 7th day, chicken group recovers normal completely.
Case 2:
Weifang raiser, raises 817 broiler chicken 10000, starts morbidity during 41 age in days, and chicken group's spirit is depressed, searches for food
Amount declines, and draws green loose stool, and indivedual chickens occur turn-taking, turning round the nervous symptoms such as neck, and every day dead more than 30 only, is cutd open inspection and dies of illness chicken, gland
Stomach nipple slight bleeding, muscular stomach horny layer bleed bottom, intestinal mucosa is hemorrhage, and Semen Jujubae shape ulcer occur in some gut associated lymphatic tissues, blind
Intestinal tonsil body swelling is hemorrhage, and heart hat fat is hemorrhage, and tunica mucosa tracheae is hemorrhage, is chronic newcastle through clinical diagnosis.Use this immediately
Invention oral liquid is treated, every chicken 0.5ml every day, and the upper and lower noon divides 2 concentration drinking-water medications, and after being used in conjunction 5 days, chicken group is dead
Stopping, spirit, appetite recover normal.
Claims (3)
1. prevent and treat a Traditional Chinese veterinary medicine oral solution for the atypical newcastle of chicken, it is characterized in that: its active component is by following weight portion
The raw material of number is made: Herba Agrimoniae 10～30 parts, Herba Lysimachiae 12～36 parts, Radix Isatidis 10～30 parts, the Radix Astragali 7～21 parts, Rhizoma Polygoni Cuspidati 10
～30 parts, Rhizoma Osmundae 18～24 parts, Radix Scutellariae 18～24 parts, Radix Ampelopsis 7～21 parts, Radix Glycyrrhizae 3～9 parts.
The Traditional Chinese veterinary medicine oral solution of the preventing and treating atypical newcastle of chicken the most according to claim 1, is characterized in that: its activity becomes
Divide and be made up of the raw material of following parts by weight: Herba Agrimoniae 20 parts, Herba Lysimachiae 24 parts, Radix Isatidis 20 parts, the Radix Astragali 14 parts, Rhizoma Polygoni Cuspidati 20
Part, Rhizoma Osmundae 21 parts, Radix Scutellariae 21 parts, Radix Ampelopsis 14 parts, 6 parts of Radix Glycyrrhizae.
3. the preparation side according to the Traditional Chinese veterinary medicine oral solution of the arbitrary described preventing and treating atypical newcastle of chicken of claim 1-2
Method, is characterized in that: comprise the steps:
(1) each raw material mixing weighing above-mentioned parts by weight is placed in Chinese medicine extracting tank, boiling 2 times, method particularly includes:
Add the water of 7 times of weight for the first time, soak 1 hour, boil 1 hour, after filtration, obtain first-time filtrate；Second time adds the water of 3 times of weight,
Boil 0.5 hour, after filtration, obtain secondary filtrate；
(2) first-time filtrate prepared in combining step (1) and secondary filtrate, obtain merging filtrate；Merging filtrate is evaporated to
Every milliliter of concentrated solution is equivalent to 1g crude drug, obtains concentrated solution；
(3) in concentrated solution step (2) prepared, addition accounts for the sodium benzoate that concentrated solution weight ratio is 0.3%, stirs, i.e.
Obtain the Traditional Chinese veterinary medicine oral solution of the described preventing and treating atypical newcastle of chicken.
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| CN109078065A (en) * | 2018-10-31 | 2018-12-25 | 衡阳市武顺循环农牧绿色生态科技有限公司 | A kind of drug and preparation method thereof for preventing and treating the mucosal checken pest of fowl |
| CN109602795A (en) * | 2018-12-25 | 2019-04-12 | 北京鑫开元医药科技有限公司 | A kind of pharmaceutical composition and its extracting method, pharmaceutical preparation, purposes |
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