CN105311615A - Traditional Chinese medicine composition for treating goose paramyxovirus disease and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating goose paramyxovirus disease and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for treating a goose paramyxovirus disease. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 18-24 parts of milkvetch root, 12-18 parts of codonopsis pilosula, 12-18 parts of kudzuvine root, 12-18 parts of Chinese thorowax root, 6-12 parts of ash bark, 10-16 parts of dried ginger and 10-16 parts of honeysuckle flower. The traditional Chinese medicine composition can be in the form of powder, and a preparation method of the traditional Chinese medicine composition comprises the following steps: (1) weighing each traditional Chinese medicine according to a formula; (2) crushing the traditional Chinese medicines, and sieving through a sieve of 80-200 meshes; (3) mixing for 5-15 minutes to obtain traditional Chinese medicine powder; and (4) sub-packaging the traditional Chinese medicine powder at 100-300g per bag to obtain a finished product. The Chinese herbal medicines selected for the formula have the effects of invigorating the spleen and replenishing qi, raising yang to stop diarrhea, clearing away heat and toxic materials, and cooling blood to relieve dysentery, so that the traditional Chinese medicine composition can be used for treating the goose paramyxovirus disease effectively, and the cure rate can reach 87.13%.
Description
Technical field
The invention belongs to Chinese veterinary drug preparation field, especially a kind of Chinese medicine composition for the treatment of goose paramyxovirus disease and preparation method thereof.
Background technology
Goose paramyxovirus disease is Late Cambrian at home in 1997, the acute infectious disease be goose a kind of being feature with symptom of digestive tract and pathological changes.Comparatively large to the harm of goose, often cause large quantities of death, young goose mortality rate can reach more than 90%, and provisions goose industry causes serious economic loss.
This disease all has stronger susceptibility to each age goose, and age in days is less, and sickness rate, mortality rate are higher.This disease, without seasonal, all can occur throughout the year, often cause endemic conditions.The incubation period of this disease is generally 3-5 days, the young goose 2-3 days that age in days is little, the goose 3-6 days that age in days is large.Sick goose spirit is tired, and drop-head hangs down wing, inappetence or refusing to eat, and amount of drinking water increases, slow in action, is reluctant lower water, keeps afloat to float with current after lower water.Sick goose draws yellow-white light stool or watery stool, is sometimes with blood to be kermesinus.Under head is inserted in wing by Adult Geese, severe patient common oral flows out watery liquid, and turns round neck, turn-takes, faces upward first-class nervous symptoms.Long the dying of exhaustion because of malnutrition of becoming thin of the course of disease, the sick goose of part can survive recovery from illness, but retarded growth.Young goose is everlasting dead in 1-2 days after morbidity, young goose, becomes the goose course of disease slightly long, is generally 3-5 days.
Cut open inspection subcutaneous pale with muscle as seen, there is petechia tiny on a small quantity on heart, liver, kidney surface.Hyperemia in various degree, the pathological changes such as hemorrhage and downright bad is had from esophagus end to cloacal whole gastrointestinal mucosal.The Alimentary tract disease of most feature is in esophagus end glandular stomach and the muscular stomach initiating terminal mucosa swelling be attached thereto, erosion, very easily peels off.Epithelium of intestinal mucosa necrosis comes off, and forms pseudomembrane together with the cellulose oozed out, and is wrapped up by intestinal contents, block enteric cavity, cause intestinal extremely to expand outward, intestinal mucosa has faint yellow or canescence Semen Sesami greatly to small broad bean large fibroid necrosis incrustation, presents courageous and upright ulcer surface after stripping.
Current goose paramyxovirus disease there is no specific treatment medicine, mainly to put prevention first.Once morbidity, immediately sick goose need be separated with healthy gaggle, avoid further infection.The intramuscular injection of report goose paramyxovirus hyper-immune serum six anti-associating penicillin is had to treat, but limited efficiency.China's natural resources of Chinese medicinal materials is extensive, and Clinical practice has the history of more than one thousand years, and treatment by Chinese herbs can play the effect for the treatment of both the principal and secondary aspects of a disease, and therefore exploitation effectively can treat the Chinese medicine composition of goose paramyxovirus disease is one of effective way solving this area difficult problem.
Summary of the invention
The problem to be solved in the present invention is: overcome the deficiencies in the prior art, provides a kind of evident in efficacy, Chinese medicine composition that cure rate is high.
Another technical problem that the present invention will solve is: provide a kind of Chinese medicine formula for the treatment of goose paramyxovirus disease.
Another technical problem that the present invention will solve is: the preparation method providing the powder of above-mentioned Chinese medicine composition.
For solving the problems of the technologies described above, the technical solution used in the present invention is: a kind of Chinese medicine composition for the treatment of goose paramyxovirus disease, is characterized in that: be prepared from by the raw material of following mass fraction: Radix Astragali 18-24 part, Radix Codonopsis 12-18 part, Radix Puerariae 12-18 part, Radix Bupleuri 12-18 part, Cortex Fraxini 6-12 part, Rhizoma Zingiberis 10-16 part, Flos Lonicerae 10-16 part.
Further, the mass fraction of the optimum feed stock of this Chinese medicine composition is as follows: the Radix Astragali 24 parts, Radix Codonopsis 16 parts, Radix Puerariae 18 parts, Radix Bupleuri 14 parts, Cortex Fraxini 6 parts, Rhizoma Zingiberis 10 parts, Flos Lonicerae 12 parts.
Further, this Chinese medicine composition is the various conventional extract oral medicine dosage form containing or do not contain pharmaceutic adjuvant.
Further, described preparation can be powder.
Further, the preparation method of the powder of said composition is: (1) takes each Chinese medicine by formula ratio; (2) Chinese medicine is pulverized, cross 80-200 mesh sieve; (3) mix 5-15 minute and obtain Chinese medicine powder; (4) Chinese medicine powder is pressed every bag of 100-300g subpackage, get product.
The advantage that the present invention has and good effect are:
(1) this prescription is according to tcm theory, and scientific compatibility, has effect of invigorating the spleen and replenishing QI, yang invigorating antidiarrheal, heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery.Through Clinical Laboratory treatment goose paramyxovirus disease determined curative effect, cure rate can reach 87.13%, thus has filled up the blank in this treatment field.
(2) this prescription selects pure natural Chinese herbal medicine to be raw material, can extensive Gains resources, and preparation technology is simple, is easy to large-scale production.
(3) pharmacological action of each raw material of Chinese medicine of the present invention is:
The Radix Astragali: air making-up and spleen enlivening, ascending up spleen-Qi and Yang;
Radix Codonopsis: spleen reinforcing lung qi, enriches blood;
Radix Puerariae: yang invigorating antidiarrheal;
Radix Bupleuri: elevate a turnable ladder yang-energy;
Cortex Fraxini: heat clearing and damp drying, astringent therapy dysentery relieving;
Rhizoma Zingiberis: warming spleen and stomach for dispelling cold, strong activating the spleen sun;
Flos Lonicerae: heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery.
Among formula, the sweet temperature of the Radix Astragali, is apt to into taste, is the key medicine of invigorating the spleen and replenishing QI.Deficiency-weakness of spleen-QI can be controlled, fatigue and weakness, anorexia and loose stool.Radix Codonopsis nature and flavor are sweet flat, and master returns spleen lung two warp, with the gas of spleen reinforcing lung for Main Function, and the empty asthenia of the body for deficiency of QI in middle-JIAO, anorexia and loose stool disease.Because it can QI invigorating can be enriched blood again, being usually used in the deficiency of vital energy can not hemopoietic, or blood deficiency is difficult activating QI, and sees the deficiency of both QI and blood of pale or sallow complexion, weak, dizzy, cardiopalmus.Radix Puerariae acrid in the mouth rises to be sent out, energy sending up the lucid YANG, inspires the gas of the clear sun of taste rise and play the effect of antidiarrheal dysentery.Radix Bupleuri also can the gas of the clear sun of elevate a turnable ladder taste, and with controlling deficiency of QI in middle-JIAO, the feeling of heaviness in the epigastrium and abdomen caused by collapse of QI is done swollen, lack of appetite asthenia, chronic diarrhea proctoptosis.Cortex Fraxini bitter cold and astringent therapy, function heat clearing and damp drying, astringent therapy dysentery relieving, leukorrhagia stopping.Rhizoma Zingiberis is hot dry strong, main enter taste and be longer than warming spleen and stomach for dispelling cold, strong activating the spleen sun, be the principal agent of warm middle Jiao, alonely can control invasion by pathogenic cold watery diarrhea.Flos Lonicerae is sweet cold, has heat-clearing and toxic substances removing, removing heat from blood, the effect of dysentery relieving, commonly uses and controls pyretic toxicity dysentery, dysentery pus and blood.
Above-mentioned seven flavor medicine compatibility uses, and has effect of invigorating the spleen and replenishing QI, yang invigorating antidiarrheal, heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery, to effectively treating goose paramyxovirus disease.
Detailed description of the invention
Be further described the present invention below by specific embodiment, following examples are descriptive, are not determinate, can not limit protection scope of the present invention with this.
Embodiment 1
Treat a Chinese powder medicine for goose paramyxovirus disease, the parts by weight of each raw material are as follows: the Radix Astragali 24 parts, Radix Codonopsis 16 parts, Radix Puerariae 18 parts, Radix Bupleuri 14 parts, Cortex Fraxini 6 parts, Rhizoma Zingiberis 10 parts, Flos Lonicerae 12 parts are prepared from.Its preparation method is: (1) takes each Chinese medicine by above-mentioned formula ratio; (2) Chinese medicine is pulverized, cross 100 mesh sieves; (3) mixing obtains Chinese medicine for 10 minutes and mixes powder; (4) Chinese medicine is mixed powder by every bag of 200g subpackage, get product.
Embodiment 2
Treat a Chinese powder medicine for goose paramyxovirus disease, the parts by weight of each raw material are as follows: the Radix Astragali 18 parts, Radix Codonopsis 12 parts, Radix Puerariae 14 parts, Radix Bupleuri 18 parts, Cortex Fraxini 12 parts, Rhizoma Zingiberis 16 parts, Flos Lonicerae 10 parts are prepared from.Its preparation method is: (1) takes each Chinese medicine by above-mentioned formula ratio; (2) Chinese medicine is pulverized, cross 100 mesh sieves; (3) mixing obtains Chinese medicine for 10 minutes and mixes powder; (4) Chinese medicine is mixed powder by every bag of 200g subpackage, get product.
Embodiment 3
Treat a Chinese powder medicine for goose paramyxovirus disease, the parts by weight of each raw material are as follows: the Radix Astragali 20 parts, Radix Codonopsis 18 parts, Radix Puerariae 12 parts, Radix Bupleuri 12 parts, Cortex Fraxini 8 parts, Rhizoma Zingiberis 14 parts, Flos Lonicerae 16 parts are prepared from.Its preparation method is: (1) takes each Chinese medicine by above-mentioned formula ratio; (2) Chinese medicine is pulverized, cross 100 mesh sieves; (3) mixing obtains Chinese medicine for 10 minutes and mixes powder; (4) Chinese medicine is mixed powder by every bag of 200g subpackage, get product.
Embodiment 4
Treat a Chinese powder medicine for goose paramyxovirus disease, the parts by weight of each raw material are as follows: the Radix Astragali 22 parts, Radix Codonopsis 15 parts, Radix Puerariae 15 parts, Radix Bupleuri 13 parts, Cortex Fraxini 9 parts, Rhizoma Zingiberis 12 parts, Flos Lonicerae 14 parts are prepared from.Its preparation method is: (1) takes each Chinese medicine by above-mentioned formula ratio; (2) Chinese medicine is pulverized, cross 100 mesh sieves; (3) mixing obtains Chinese medicine for 10 minutes and mixes powder; (4) Chinese medicine is mixed powder by every bag of 200g subpackage, get product.
Clinical trial
Experiment 1:
The a collection of 35-60 age in days goose that Handan in Hebei province egg goose raiser raises, householder finds that gaggle sporadicly falls ill.Sick goose shows as lassitude, loss of appetite, and feather is loose, two skelasthenia, and paralysis, is reluctant to walk about, and peel off slow-witted standing, and draw yellow-white loose stool, blood stool and the intestinal mucosa come off, head and neck bends backward, i.e. death in 3-4 days after morbidity.Cut open inspection to die of illness goose its intestinal bleeding visible, mucosa comes off, and small intestinal has a large amount of yellow-white thromboembolism, the watery feces of rectum cloaca adularescent.According to incidence and clinical symptoms, be tentatively judged as goose paramyxovirus disease.The whole buried process of goose so will die of illness, morbidity goose is isolated for treatment, and spice is fed the Chinese powder medicine obtained by the embodiment of the present invention 1, and spice is fed than being 200g Chinese powder medicine: 150Kg feedstuff, one day 2 times, is used in conjunction 7 days.Simultaneously with new P&G sterilization goose house, once a day.After medication, namely second day gaggle death toll amount reduce, and within the 3rd day, reduces to 4, within the 4th day, no longer occurs death.After 1 week, sick goose mental restoration, appetite increases, and freely, defecation frequency and form all recover normal in activity, and jumpbogroup is fully recovered.
Test 1 result to show, the Chinese powder medicine obtained by patent Example 1 of the present invention effectively can treat goose paramyxovirus disease, reduces gaggle mortality rate, reduces the economic loss of raiser.
Experiment 2
1500 plumage goose Seedlings are bought at Yangzhou foster goose family in Jiangsu Province's from other places, raise to starting morbidity during 45 age in days.Sick goose spirit is tired, and eyelid is red and swollen, and feather is fluffy and disorderly.Slow-witted vertical, slow in action unable or can not throw oneself on the ground, the single foot had is mentioned.Loss of appetite, amount of drinking water increases.Their early stage draws white light stool, and the later stage draws watery stools, in dark red, yellow green or blackish green.I.e. death in 2-3 days after morbidity.Cut open the downright bad or intestinal mucosa of visible whole being dispersed in property of the mucous membrane of small intestine fibrin of inspection to have canescence or faint yellow Semen Sesami arrive greatly the large fibroid of small broad bean to form a scab, after stripping, have hemorrhagic ulcer face.Cecal tonsil enlargement, obviously hemorrhage.Cloaca mucous hyperemia, gastrorrhagia, hyperemia.According to incidence, clinical symptoms with cut open inspection result, preliminary judgement is goose paramyxovirus disease.
The whole audience adds up to the morbidity of 634 geese, first three day dead 28.Sick for death goose is cooked buried process, prevents to all the other gaggle injection goose paramyxovirus deactivation immune vaccines of not falling ill.606 the sick geese fallen ill are isolated for treatment.Sick goose is divided into three groups, often organizes 202.First group of 0.01% ribavirin+0.01% ofloxacin drinking-water, one day 2 times, is used in conjunction 5 days; Second group of subcutaneous injection goose paramyxovirus hyper-immune serum 2ml/ plumage, one day 1 time, is used in conjunction 3 days; The 3rd group of Chinese powder medicine that spice is fed obtained by the embodiment of the present invention 1, one day 2 times, is used in conjunction 5 days, and spice is than being 200g:150Kg feedstuff.
Sick goose mental restoration, appetite are normal, freedom of movement, stool form and number of times all recover normal for curing; Sick goose spirit takes a turn for the better, and appetite increases, and just number of times of having loose bowels reduces, and what form took a favorable turn is effective; After treatment symptom have no improvement even worsen or death for invalid.Observe the curative effect of each group, the results are shown in Table 1.
Table 1 different pharmaceutical treatment goose paramyxovirus disease experimental result
As can be seen from Table 1, diseases caused by retention of fluid ribavirin and the curative effect of ofloxacin to goose paramyxovirus disease poor (59.41%), mortality rate is up to 37.62%.And adopt the Chinese powder medicine treatment goose paramyxovirus disease obtained by the embodiment of the present invention 1, good effect can be obtained, cure rate and effective percentage are respectively 87.13% and 5.94%, be better than 76.24% and 4.95% of goose paramyxovirus hyper-immune serum group, and between two groups, there is significant significant difference, P >=0.05.
The above, be only preferred embodiments of the present invention, is illustrative instead of determinate, can list several embodiments according to limited range, therefore in the change do not departed under general plotting of the present invention and amendment, should belong within protection scope of the present invention.
Claims (5)
1. treat a Chinese medicine composition for goose paramyxovirus disease, it is characterized in that, be prepared from by the raw material of following mass fraction:
Radix Astragali 18-24 part, Radix Codonopsis 12-18 part, Radix Puerariae 12-18 part, Radix Bupleuri 12-18 part, Cortex Fraxini 6-12 part, Rhizoma Zingiberis 10-16 part, Flos Lonicerae 10-16 part.
2. a kind of Chinese medicine composition for the treatment of goose paramyxovirus disease according to claim 1, is characterized in that: the mass fraction of optimum feed stock is as follows:
The Radix Astragali 24 parts, Radix Codonopsis 16 parts, Radix Puerariae 18 parts, Radix Bupleuri 14 parts, Cortex Fraxini 6 parts, Rhizoma Zingiberis 10 parts, Flos Lonicerae 12 parts.
3. a kind of Chinese medicine composition for the treatment of goose paramyxovirus disease according to claim 1 and 2, is characterized in that: this Chinese medicine composition is the various conventional extract oral medicine dosage form containing or do not contain pharmaceutic adjuvant.
4. a kind of Chinese medicine composition for the treatment of goose paramyxovirus disease according to claim 3, is characterized in that: described preparation can be powder.
5. prepare an a kind of method for the treatment of the Chinese powder medicine of goose paramyxovirus disease as claimed in claim 4, it is characterized in that, preparation method is: (1) takes each Chinese medicine by formula ratio; (2) Chinese medicine was pulverized 80-200 mesh sieve; (3) mix 5-15 minute and obtain Chinese medicine powder; (4) Chinese medicine powder is pressed every bag of 100-300g subpackage, get product.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110840973A (en) * | 2019-12-17 | 2020-02-28 | 河南牧业经济学院 | Traditional Chinese veterinary medicine powder for preventing goose viral diseases and preparation method thereof |
| CN115969951A (en) * | 2022-12-28 | 2023-04-18 | 华农（肇庆）生物产业技术研究院有限公司 | Anti-diarrhea preparation for treating pets and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101757297A (en) * | 2009-07-24 | 2010-06-30 | 王直军 | Chinese medicine fodder additive for preventing and treating poultry paramyxovirus and influenza |
| CN102048054A (en) * | 2010-09-29 | 2011-05-11 | 吴艳霞 | Traditional Chinese medicine feed additive used for preventing and treating poultry paramyxovirus influenza |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110840973A (en) * | 2019-12-17 | 2020-02-28 | 河南牧业经济学院 | Traditional Chinese veterinary medicine powder for preventing goose viral diseases and preparation method thereof |
| CN115969951A (en) * | 2022-12-28 | 2023-04-18 | 华农（肇庆）生物产业技术研究院有限公司 | Anti-diarrhea preparation for treating pets and preparation method thereof |
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Application publication date: 20160210 |