CN110840973A - Traditional Chinese veterinary medicine powder for preventing goose viral diseases and preparation method thereof - Google Patents
Traditional Chinese veterinary medicine powder for preventing goose viral diseases and preparation method thereof Download PDFInfo
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- CN110840973A CN110840973A CN201911302221.3A CN201911302221A CN110840973A CN 110840973 A CN110840973 A CN 110840973A CN 201911302221 A CN201911302221 A CN 201911302221A CN 110840973 A CN110840973 A CN 110840973A
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Abstract
The invention discloses a traditional Chinese veterinary medicine powder for preventing goose viral diseases, which is prepared from the following components in parts by weight: 1-5 parts of radix salviae miltiorrhizae, 10-20 parts of radix isatidis, 3-6 parts of rhizoma acori graminei, 1-5 parts of florists chrysosporium, 1-5 parts of ligusticum wallichii, 2-8 parts of pyrrosia lingua, 10-15 parts of radix puerariae, 10-20 parts of liquorice and 5-10 parts of orange peel. The invention also provides a preparation method of the traditional Chinese veterinary medicine powder for preventing goose viral diseases. The invention also provides a preparation method of the traditional Chinese veterinary medicine powder for preventing goose viral diseases. The traditional Chinese veterinary medicine powder provided by the invention is suitable for clearing away heat and toxic materials, promoting diuresis and reducing edema, treating damp-heat diarrhea, inhibiting virus and bacteria proliferation and improving the immunity of the body.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese veterinary medicines, and particularly relates to a traditional Chinese veterinary medicine powder for preventing goose viral diseases and a preparation method thereof.
Background
Goose has strong disease resistance in poultry and has few disease types. With the rapid development of the intensive production of the goose farming industry. The kinds of diseases of geese are more and more. In recent years, viral or bacterial virulent infectious diseases such as goose paramyxovirus disease, goose influenza, goose hemorrhagic necrotizing hepatitis and the like are discovered successively. Especially, the recent outbreak of avian influenza hinders the healthy development of goose breeding industry.
At present, goose paramyxovirus disease is a new infectious disease, is an acute infectious disease characterized by digestive tract pathological changes, has a high morbidity, and particularly has a morbidity and mortality rate of goslings within 10 days of age of 100 percent and a morbidity and mortality rate of goslings within 10-15 days of age of more than 90 percent; if the vaccination to the goose paramyxovirus disease is not timely in the breeding process, serious economic loss is caused to the goose breeding industry. In the prior art, after goose paramyxovirus is attacked, antiviral serum or yolk antibody is generally adopted for treatment, but the antiviral western medicines for poultry are few, expensive and high in side effect, and the powerful antiviral western medicines are particularly utilized to induce teratogenesis. The traditional Chinese medicine has good antiviral effect, small side effect and no drug resistance, but the existing traditional Chinese medicine for preventing goose paramyxovirus disease is deficient in information, so that in order to prevent goose paramyxovirus disease, inhibit virus and bacteria proliferation and improve goose organism immunity, the traditional Chinese medicine with good prevention effect and low toxic and side effect is searched for according to the theory of dialectical treatment of Chinese veterinary medical science and prescription, starting from the whole body, and the purpose of treating the root cause is achieved. Has important social significance for inhibiting the spreading of goose paramyxovirus disease and has important economic value for many goose breeders.
Disclosure of Invention
In order to solve the defects in the background art, the invention aims to provide a traditional Chinese veterinary medicine powder for preventing goose viral diseases and a preparation method thereof.
In order to achieve the purpose, the invention adopts the following technical scheme:
the invention aims to provide a traditional Chinese veterinary medicine powder for preventing goose viral diseases, which is prepared from the following raw materials in parts by weight: 1-5 parts of radix salviae miltiorrhizae, 10-20 parts of radix isatidis, 3-6 parts of rhizoma acori graminei, 1-5 parts of florists chrysosporium, 1-5 parts of ligusticum wallichii, 2-8 parts of pyrrosia lingua, 10-15 parts of radix puerariae, 10-20 parts of liquorice and 5-10 parts of orange peel.
Preferably, the raw materials comprise the following components in parts by weight: 2 parts of radix salviae miltiorrhizae, 15 parts of radix isatidis, 4 parts of rhizoma acori graminei, 3 parts of Ardisia punctata, 2 parts of ligusticum wallichii, 5 parts of pyrrosia lingua, 12 parts of radix puerariae, 15 parts of liquorice and 8 parts of orange peel.
The second purpose of the invention is to provide a preparation method of the traditional Chinese veterinary medicine powder for preventing goose viral diseases, which comprises the following steps:
s1, weighing the following raw materials in parts by weight: 1-5 parts of radix salviae miltiorrhizae, 10-20 parts of radix isatidis, 3-6 parts of rhizoma acori graminei, 1-5 parts of florists chrysosporium, 1-5 parts of ligusticum wallichii, 2-8 parts of pyrrosia lingua, 10-15 parts of radix puerariae, 10-20 parts of liquorice and 5-10 parts of orange peel for later use;
s2, crushing the raw material medicines weighed by the S1 into particles, adding water to soak for 2-4 h: adding water into the soaked raw materials, decocting for 2-4 times, adding water in an amount which is 6-8 times of the total amount of the raw materials for the first time, decocting for 1.5-2 hours, taking decoction, and filtering; then adding water in an amount which is 4-6 times that of the total raw materials, decocting for 1.0-2 h, taking decoction, and filtering; mixing decoctions, and filtering to obtain filtrate;
s3, concentrating the filtrate obtained in the step S2 under reduced pressure to be thick paste, and drying the thick paste to be powder to obtain a raw medicine preparation;
s4, adding auxiliary materials into the original medicine preparation obtained in the step S3, and uniformly mixing to obtain the traditional Chinese veterinary medicine powder.
The pharmacological action and the drug effect of the traditional Chinese medicine of the invention are as follows:
red yam: bitter, slightly astringent and cool in nature; spleen, stomach, large intestine and liver meridians entered; the efficacy is as follows: clearing away heat and toxic material, cooling blood and promoting blood circulation; the main treatment is as follows: respiratory tract infection, tonsillitis, acute bacillary dysentery, acute enteritis, urinary system infection, various hemorrhage, traumatic injury, menoxenia, rheumatic arthralgia, toxic heat, pyocutaneous disease, and burn.
Radix isatidis: bitter and cold; heart and stomach meridians entered; the efficacy is as follows: clearing away heat and toxic materials, cooling blood, and relieving sore throat; the main treatment is as follows: epidemic febrile disease, fever, pharyngalgia, epidemic macula, mumps, throat rot, erysipelas, fever with swollen head, erysipelas, and carbuncle.
Grassleaf sweelflag rhizome: bitter and slightly pungent in taste; resolving dampness, promoting appetite, inducing resuscitation, eliminating phlegm, refreshing mind, and improving intelligence; can be used for treating epigastric fullness, inappetence, dysentery, coma, epilepsy, amnesia, and deafness. Regulating qi, promoting blood circulation, dispelling pathogenic wind, and removing dampness; it can be used for treating epilepsy, phlegm syncope, fever, coma, amnesia, qi block, deafness, vexation, gastralgia, abdominal pain, arthralgia due to wind-cold-dampness, superficial infection, toxic swelling, and traumatic injury.
A small umbrella: bitter, sweet and pungent taste and warm nature; it enters liver, bladder and kidney meridians; promoting blood circulation for regulating menstruation, dispelling pathogenic wind and removing dampness; can be used for treating amenorrhea, dysmenorrhea, rheumatalgia, and traumatic injury;
ligusticum wallichii: pungent and warm; entering liver and gallbladder meridians; promoting qi circulation, relieving depression, dispelling wind-dryness and dampness, promoting blood circulation, and relieving pain; it is indicated for wind-cold headache, dizziness, hypochondriac pain, abdominal pain, cold arthralgia, spasm of tendons, amenorrhea, dystocia, postpartum pain due to blood stasis, carbuncle, cellulitis, sore and ulcer. Can be used for treating menoxenia, amenorrhea, dysmenorrhea, abdominal pain, pricking pain in chest and hypochondrium, traumatic injury, swelling and pain, headache, and rheumatalgia.
And (3) reed: bitter taste and cold nature, induce diuresis to treat stranguria, clear lung-heat and purge heat. It can be used for treating stranguria, hematuria, lithangiuria, nephritis, metrorrhagia, dysentery, cough due to lung heat, chronic tracheitis, incised wound, and superficial infection.
Kudzu root: sweet and pungent in flavor and cool in nature; entering lung and stomach meridians; relieving muscles and fever, promoting eruption, promoting fluid production to quench thirst, invigorating yang and relieving diarrhea; can be used for treating fever due to exterior syndrome, pain of neck and back, measles without adequate eruption, thirst due to fever, diabetes due to yin deficiency, dysentery due to heat-purging, and diarrhea due to spleen deficiency.
Licorice root: sweet in taste and neutral in nature; entering heart, lung, spleen and stomach meridians; has the effects of invigorating spleen and replenishing qi, clearing away heat and toxic materials, eliminating phlegm and relieving cough, relieving spasm and pain, and harmonizing the medicines; can be used for treating weakness of spleen and stomach, asthenia, palpitation, short breath, cough, excessive phlegm, abdominal and limb spasm, pain, carbuncle, swelling, sore, and drug toxicity and strong nature.
Orange peel: pungent, slightly bitter and warm in flavor, entering spleen and lung meridians; has the effects of regulating qi, regulating middle energizer, eliminating dampness and resolving phlegm, and can be used with cautions for treating chest distress, anorexia and loose stool due to spleen and stomach qi stagnation, abdominal distention, emesis or damp-turbidity obstruction in middle energizer, but with internal excess heat.
Compared with the prior art, the invention has the beneficial effects that:
the traditional Chinese veterinary medicine powder for preventing the goose viral diseases provided by the invention takes the red-rooted salvia roots, the indigowoad roots and the grassleaf sweelflag rhizome as monarch medicines, and has the effects of clearing away heat and toxic materials, refreshing mind and promoting intelligence; the Ardisia floribunda and the Ligusticum wallichii are taken as ministerial drugs, so that the effects of dispelling wind and removing dampness, promoting blood circulation to arrest pain, clearing away the lung-heat and clearing away heat are achieved; herba pyrrosiae and radix puerariae are used as adjuvant drugs, and the traditional Chinese medicine composition has the effects of promoting diuresis, treating stranguria, clearing away lung-heat, clearing away heat, promoting the production of body fluid, quenching thirst, invigorating yang and relieving diarrhea; the liquorice and the orange peel are used as guiding drugs, the spleen is tonifying and qi is benefited, the heat and toxic materials are cleared away, the qi is regulated and the middle warmer is regulated, the dampness and phlegm are eliminated, the effects of regulating the effects of the drugs are achieved, the medicine is suitable for clearing away heat and toxic materials, promoting diuresis and reducing edema, damp and hot diarrhea, inhibiting virus and bacteria proliferation and improving the immunity of the organism, especially the scattering of goose paramyxovirus disease can be effectively prevented, and the medicine has important economic value for a plurality of goose farmers.
Detailed Description
In order to make the technical solutions of the present invention better understood and enable those skilled in the art to practice the present invention, the following embodiments are further described, but the present invention is not limited to the following embodiments.
Example 1
A traditional Chinese veterinary medicine powder for preventing goose viral diseases is prepared from the following components in parts by weight: 2g of radix salviae miltiorrhizae, 15g of radix isatidis, 4g of rhizoma acori graminei, 3g of florists chrysosporium, 2g of ligusticum wallichii, 5g of folium pyrrosiae, 12g of radix puerariae, 15g of liquorice and 8g of orange peel.
The preparation method of the traditional Chinese veterinary medicine powder comprises the following steps:
s1, weighing the following raw materials in parts by weight: 2g of radix salviae miltiorrhizae, 15g of radix isatidis, 4g of rhizoma acori graminei, 3g of florists chrysosporium, 2g of ligusticum wallichii, 5g of folium pyrrosiae, 12g of radix puerariae, 15g of liquorice and 8g of orange peel for later use;
s2, crushing the raw material medicines weighed by the S1 into particles, adding water to soak the particles for 3 h: decocting the soaked raw materials in water for 3 times, adding water 7 times the amount of the raw materials for the first time, decocting for 1.5 hr, collecting decoction, and filtering; secondly, adding water in an amount which is 5 times that of the total raw materials, decocting for 2 hours, taking decoction, and filtering; thirdly, adding water which is 5 times of the total amount of the raw materials, decocting for 2 hours, taking decoction, and filtering; mixing decoctions, and filtering to obtain filtrate;
s3, concentrating the filtrate obtained in the step S2 under reduced pressure to be thick paste, and drying the thick paste to be powder to obtain a raw medicine preparation;
s4, adding auxiliary materials including 5g of propionic acid and 3g of sodium glutamate into the original medicine preparation obtained in the step S3, and uniformly mixing to obtain the traditional Chinese veterinary medicine powder.
Example 2
A traditional Chinese veterinary medicine powder for preventing goose viral diseases is prepared from the following components in parts by weight: 1g of radix Polygoni Ciliinerve, 10g of radix Isatidis, 3g of rhizoma Acori Graminei, 1g of Ardisia punctata, 1g of rhizoma Ligustici Chuanxiong, 2g of folium Pyrrosiae, 10g of radix Puerariae, 10g of Glycyrrhrizae radix, and 5g of pericarpium Citri Tangerinae.
The preparation method of the traditional Chinese veterinary medicine powder comprises the following steps:
s1, weighing the following raw materials in parts by weight: 1g of radix Polygoni Ciliinerve, 10g of radix Isatidis, 3g of rhizoma Acori Graminei, 1g of Ardisia punctata, 1g of rhizoma Ligustici Chuanxiong, 2g of folium Pyrrosiae, 10g of radix Puerariae, 10g of Glycyrrhrizae radix, and 5g of pericarpium Citri Tangerinae;
s2, crushing the raw material medicines weighed by the S1 into particles, adding water to soak for 2 h: decocting the soaked raw materials in water for 4 times, adding water 8 times the amount of the raw materials for the first time, decocting for 1.5 hr, collecting decoction, and filtering; secondly, adding water in an amount which is 4 times that of the total raw materials, decocting for 1.0h, taking decoction, and filtering; thirdly, adding water in an amount which is 4 times that of the total raw materials, decocting for 1.0h, taking decoction, and filtering; mixing decoctions, and filtering to obtain filtrate;
s3, concentrating the filtrate obtained in the step S2 under reduced pressure to be thick paste, and drying the thick paste to be powder to obtain a raw medicine preparation;
s4, adding auxiliary materials including 3g of propionic acid and 2g of sodium glutamate into the original medicine preparation obtained in the step S3, and uniformly mixing to obtain the traditional Chinese veterinary medicine powder.
Example 3
A traditional Chinese veterinary medicine powder for preventing goose viral diseases is prepared from the following components in parts by weight: 5g of radix Polygoni Ciliinerve, 20g of radix Isatidis, 6g of rhizoma Acori Graminei, 5g of Ardisia punctata, 5g of rhizoma Ligustici Chuanxiong, 8g of folium Pyrrosiae, 15g of radix Puerariae, 20g of Glycyrrhrizae radix, and 10g of pericarpium Citri Tangerinae.
The preparation method of the traditional Chinese veterinary medicine powder comprises the following steps:
s1, weighing the following raw materials in parts by weight: 5g of radix salviae miltiorrhizae, 20g of radix isatidis, 6g of rhizoma acori graminei, 5g of florists chrysosporium, 5g of ligusticum wallichii, 8g of folium pyrrosiae, 15g of radix puerariae, 20g of liquorice and 10g of orange peel for later use;
s2, crushing the raw material medicines weighed by the S1 into particles, adding water to soak for 4 h: decocting the soaked raw materials in water for 2 times, adding 6 times of water for the first time, decocting for 2 hr, collecting decoction, and filtering; secondly, adding 6 times of water into the total amount of the raw materials, decocting for 2h, taking decoction, and filtering; mixing decoctions, and filtering to obtain filtrate;
s3, concentrating the filtrate obtained in the step S2 under reduced pressure to be thick paste, and drying the thick paste to be powder to obtain a raw medicine preparation;
s4, adding auxiliary materials including 8g of propionic acid and 5g of sodium glutamate into the original medicine preparation obtained in the step S3, and uniformly mixing to obtain the traditional Chinese veterinary medicine powder.
The veterinary drug powder for preventing goose viral diseases provided in examples 1 to 3, and the therapeutic effects of the oral veterinary drug powder provided in examples 1 to 3 are substantially parallel, so the effects of the present invention will be described below by using only the veterinary drug powder prepared in example 1 as an example.
The effects of the present invention will be further described below using clinical tests.
Clinical trial
1 general data
Selecting 30-60 days old geese bred by a plurality of laying goose farmers, and selecting 820 geese with goose paramyxovirus disease symptoms.
The selection basis is as follows:
1) the goose is white and thin feces at the early stage of illness, and then is water-like with dark red, yellow or green color.
2) Listlessness, fluffy feather, weakness of limbs and squat,
3) when one foot is lifted all the time, the appetite is reduced or the goose is abolished, the breeding geese stop laying eggs but drink water is increased,
4) then, nerve symptoms such as cervical sprain, split cleft, etc. were found.
2. Method of treatment
2.1 goose groups
The intervention study was carried out by randomly dividing the geese 820 having symptoms of goose paramyxovirus disease into a treatment group and a control group according to a random number table method.
Treatment groups: 410 geese with paramyxovirus disease symptoms, wherein the white thin manure 102, the two limbs of which are weak and the ground 87 squat, are lifted 114 by one foot, and the neck is twisted and the split 107 is split;
control group: 410 goose with paramyxovirus disease symptoms, wherein the white thin feces 115, two limbs of which are weak, squat the ground 85, lift 96 with one foot, twist neck and split 104.
2.2 methods of treatment
Treatment groups: the oral traditional Chinese veterinary medicine powder prepared in the embodiment 1 of the invention is taken twice a day in the morning and at night, and the dosage of the traditional Chinese veterinary medicine powder provided in the embodiment 1 is 0.1-0.3% of the weight of the feed taken each time, and the traditional Chinese veterinary medicine powder is taken together with the feed.
Control group: the ribavirin tablets are taken twice a day in the morning and at night, and the weight of the ribavirin tablets taken each time accounts for 0.05-0.1% of the weight of the feed taken each time, and the ribavirin tablets and the feed are taken together.
The two groups are administered simultaneously for 5 days.
3. Criteria for therapeutic effect
And (3) curing: the sick goose recovers the spirit, the appetite is normal, the goose moves freely, and the stool form and times are all recovered to be normal;
the effect is shown: the sick goose has improved spirit, increased appetite, reduced diarrhea frequency and improved shape;
the method has the following advantages: the symptoms of the patients are improved, the symptoms are not completely eliminated, and the patients need to continue to take the medicine after lifting the feet occasionally;
and (4) invalidation: the symptoms did not go well or even worsen or die after treatment.
4. The results of the clinical trials are shown in table 1.
TABLE 1 results of clinical trials
As can be seen from table 1, the cure rates, the death rates and the total effective rates of the two groups are all less than 0.05, and significant differences exist, the test results of the oral traditional Chinese veterinary medicine powder provided by the embodiment 1 of the invention show that the total effective rate is as high as 94%, the cure rate is 69%, the death rate is 1.7%, and the total effective rate of the control group is 95%, the cure rate is 71% and the death rate is 2.6%, which indicates that the effect of the traditional Chinese veterinary medicine powder for preventing goose paramyxovirus disease is similar to the antiviral effect of the powerful antiviral western medicine, but the death rate of the antiviral western medicine is slightly higher than that of the traditional Chinese veterinary medicine powder provided by the invention, and further shows that the traditional Chinese veterinary medicine powder provided by the invention has small side effect, can effectively prevent the scattering of goose paramyxovirus disease, and has important economic value for many goose farmers.
It should be noted that when the following claims refer to numerical ranges, it should be understood that both ends of each numerical range and any value between the two ends can be selected, and since the steps and methods used are the same as those of the embodiments, the preferred embodiments of the present invention have been described for the sake of avoiding redundancy, and although the preferred embodiments of the present invention have been described, those skilled in the art may make other changes and modifications to the embodiments once they learn the basic inventive concept. Therefore, it is intended that the appended claims be interpreted as including preferred embodiments and all such alterations and modifications as fall within the scope of the invention.
It will be apparent to those skilled in the art that various changes and modifications may be made in the present invention without departing from the spirit and scope of the invention. Thus, if such modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include such modifications and variations.
Claims (3)
1. The traditional Chinese veterinary medicine powder for preventing goose viral diseases is characterized by comprising the following raw materials in parts by weight: 1-5 parts of radix salviae miltiorrhizae, 10-20 parts of radix isatidis, 3-6 parts of rhizoma acori graminei, 1-5 parts of florists chrysosporium, 1-5 parts of ligusticum wallichii, 2-8 parts of pyrrosia lingua, 10-15 parts of radix puerariae, 10-20 parts of liquorice and 5-10 parts of orange peel.
2. The traditional Chinese veterinary medicine powder for preventing goose viral diseases according to claim 1, which is prepared from the following raw materials in parts by weight: 2 parts of radix salviae miltiorrhizae, 15 parts of radix isatidis, 4 parts of rhizoma acori graminei, 3 parts of Ardisia punctata, 2 parts of ligusticum wallichii, 5 parts of pyrrosia lingua, 12 parts of radix puerariae, 15 parts of liquorice and 8 parts of orange peel.
3. The preparation method of the veterinary Chinese medicine powder for preventing goose viral diseases, which is disclosed by claim 1, is characterized by comprising the following steps of:
s1, weighing the following raw materials in parts by weight: 1-5 parts of radix salviae miltiorrhizae, 10-20 parts of radix isatidis, 3-6 parts of rhizoma acori graminei, 1-5 parts of florists chrysosporium, 1-5 parts of ligusticum wallichii, 2-8 parts of pyrrosia lingua, 10-15 parts of radix puerariae, 10-20 parts of liquorice and 5-10 parts of orange peel for later use;
s2, crushing the raw material medicines weighed by the S1 into particles, adding water to soak for 2-4 h: adding water into the soaked raw materials, decocting for 2-4 times, adding water in an amount which is 6-8 times of the total amount of the raw materials for the first time, decocting for 1.5-2 hours, taking decoction, and filtering; then adding water in an amount which is 4-6 times that of the total raw materials, decocting for 1.0-2 h, taking decoction, and filtering; mixing decoctions, and filtering to obtain filtrate;
s3, concentrating the filtrate obtained in the step S2 under reduced pressure to be thick paste, and drying the thick paste to be powder to obtain a raw medicine preparation;
s4, adding auxiliary materials into the original medicine preparation obtained in the step S3, and uniformly mixing to obtain the traditional Chinese veterinary medicine powder.
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