CN105998970A - Pharmaceutical composition for treating canine infectious bronchitis and preparation method thereof - Google Patents

Pharmaceutical composition for treating canine infectious bronchitis and preparation method thereof Download PDF

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CN105998970A
CN105998970A CN201610384917.5A CN201610384917A CN105998970A CN 105998970 A CN105998970 A CN 105998970A CN 201610384917 A CN201610384917 A CN 201610384917A CN 105998970 A CN105998970 A CN 105998970A
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weight portion
weight
radix
herba
pharmaceutical composition
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衣文娟
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Yantai Minwang Electromechanical Technology Co Ltd
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Yantai Minwang Electromechanical Technology Co Ltd
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/06—Fungi, e.g. yeasts
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Abstract

The invention discloses a pharmaceutical composition for treating canine infectious bronchitis and a preparation method thereof. The pharmaceutical composition comprises the following raw materials: Japanese ardisia root, Ventilago leiocarpa Benth, Polemonium caeruleum, chicory, ginkgo, veined inula root, dandelion, fimbriatestipulate begonia herb, wehling lindera root, greyblue spicebush root, Ligularia dentate, Ganoderma lucidum, largeleaf violet herb, oroxylum indicum, radix stemonae, honeysuckle, Gynostemma, marshy betony herb, Photinia villosa, Eurya groffii, Abacopteris triphylla, Medicago lupulina, Hongkong rhaphidophora herb, Yunnan bulbophyllum herb, Japanese youngia herb or root and Ceratostigma willmottianum Stapf. The invention has beneficial effects that the pharmaceutical composition for treating canine infectious bronchitis has the effects of resisting bacteria, relieving inflammation, eliminating phlegm, relieving cough and moistening, has the advantages of high efficiency, curative effect, reduction of mortality rate, high cure rate, and no toxic or side effect. Compared with the traditional medicine, the pharmaceutical composition has the characteristics of short healing time, short course of treatment, good curative effect high safety and strong pertinency.

Description

A kind of pharmaceutical composition treating Infectious Tracheobroncheitis and preparation method thereof
Technical field
The present invention relates to veterinary drug technical field, particularly to a kind of pharmaceutical composition treating Infectious Tracheobroncheitis and Its preparation method.
Background technology
Infectious Tracheobroncheitis (ITB) is commonly referred to dog and coughs or disease coughed by dog nest, have break out, sudden cough, Irregularly spit, a kind of hyperinfection respiratory tract disease of the feature such as eye nasal discharge.
The clinical symptoms of Infectious Tracheobroncheitis: 1, occurred most frequently in summer and autumn without complication ITB, break out, Sudden cough, and with nausea and vomiting shape, the then bouncing vocal fold swelling of other aspect dogs may result in cough, spits, often quilt Poultry is main is mistaken for vomiting, generally has the history contacted with other Canis familiaris L.s or doghouse before 3-7 days.Although easily can be lured by treatment of organs Lead cough, but the most notable.As without complication, need not treat and can recover voluntarily.2, there are complication ITB canine distemper, hepatitis and sidestream The Canis familiaris L. that cold and raising immunity history is not clear, has more serious cough, respiratory symptom, has antibacterial accompanying infection, it is more likely that have recently In other doghouses, pet shop, post the history that the ground such as kennel, veterinary hospital stayed.Cough can be produced or do not produce cough.Disease Shape shows themselves in that body temperature rising-depressed, loss of appetite of spirit or dyspnea-mucus are to coctum eye nasal discharge.With The relevant complication of tracheal pneumonia can threat to life.
Primary disease infected dogs and fox, the dog at various ages all can infection morbidity, below 4 monthly ages, pup sickness rate is higher, Especially just wean pup susceptible disease soon, thereby increases and it is possible to cause death.Dog infect this most after being ill can for a long time band poison, disease dog, disease Vulpes and carrier thereof are the sources of infection of primary disease.This disease be high degree in contact infect, by air through respiratory tract be its main propagation Approach.Dog is once had to fall ill in the dog group of dense husbandry, just can be the most popular, and be difficult to eradicate, pup can fall ill by whole nest, latent General 5-10 days of volt phase.
The virus of Infectious Tracheobroncheitis and I type hepatitis infectiosa canis virus belong to mammalian adenoviruses together, and the latter causes dog infection Property hepatitis.The two is not only related but also have any different, and II type hepatitis infectiosa canis virus is a variant of I type, with II type hepatitis infectiosa canis virus vaccine The dog of immunity, can produce the stronger immunity to infectious hepatitis.
The clinical examination of Infectious Tracheobroncheitis: luring and cough substantially, trachea auscultation has rale, and body temperature might not raise, In early days may be normal, when secondary has antibacterial infect or develop into pneumonia, body temperature Chang Zhongdu raises (about 39.5 DEG C).Primary disease is also Easily and the mixed infection such as canine distemper, parainfluenza, Simplex Virus, at this moment complicated symptoms and serious, mortality rate is the highest.
Infectious Tracheobroncheitis pathological change: cut open inspection and die of illness dog, mainly see pneumonia and bronchitis pathological changes.Pulmonary congestion, Consolidation, atelectasis;Bronchial lymph nodes is congested, hemorrhage, and bronchial mucosa is congested, becoming fragile or seeing thickens, and tube chamber has a large amount of points Secretion.The most visible Hypertrophic adenoma focus.Primary disease is finally made a definite diagnosis and must be relied on virus purification and Serological testing, and pathological material of disease is adopted Take respiratory secretions and respiratory apparatus tissue.
The prophylactico-therapeutic measures of Infectious Tracheobroncheitis: (1) treat.There is no the medicine of specially good effect at present, answer intensive care, Improve nutrition, symptomatic treatment and prevent secondary infection.Warming to be paid special attention on Hu Li, symptomatic treatment is with cough-relieving, flat Breathe heavily, antiinflammatory is main, and prevention bacterial infection preferably selects broad-spectrum antibiotic and some can reach effective in trachea-bronchial epithelial cell mucosa The medicine of concentration.Medicine as conventional has: codeine, dihydrocodeinone, stadol, hydration terpene two fine wine codeine, Thailand Happy rhzomorph, tetracycline, kanamycin, cephalosporin, chlortetracycline etc..Cortex class, steroid therapy have antiinflammation, contribute to subtracting The clinical symptoms of hypopathia dog, conventional dexamethasone, meticortelone etc., but must use with Antibiotic combination.Intratracheal instillation or Spraying uses acetyl cysteine also to have preferable expelling phlegm for arresting cough effect.(2) prevent.The domestic specificity vaccine that there is no at present can be used, Having ready conditions and import dog six Seedling can be used to carry out immunity inoculation, Intervet company of Holland produces at present " vaccine coughed by dog nest " takes Collunarium method, no pain, i.e. can reach preventive effect.Other preventive measure, with general infectious disease, should be specifically noted that reinforcement is raised Manage, periodically sterilize and quarantine, prevent virus incoming.Once morbidity should isolate disease dog early, and the morbidity of whole nest also should be suitable Evacuate, should treat in time simultaneously, and carry out environment disinfected.
Current medicine effect is the most prominent, therefore researches and develops a kind of specific medicament treating Infectious Tracheobroncheitis It it is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The technical problem to be solved is: provide a kind of pharmaceutical composition treating Infectious Tracheobroncheitis and Its preparation method, the medicine composite for curing dog pneumonia of the present invention is by anti-inflammation, expelling phlegm for arresting cough, wets one's whistle, and can play effect Rate is high, determined curative effect, reduces mortality rate, and cure rate is high, has no side effect, relative to conventional medicament on therapeutic effect, has The features such as healing time is short, short treating period, good effect, and safety is high, with strong points.
In order to realize foregoing invention purpose, the invention provides a kind of drug regimen treating Infectious Tracheobroncheitis Thing, described pharmaceutical composition includes following raw medicinal material: Radix ardisiae japonicae, Radix Cudraniae, flower, Herba Cichorii, Semen Ginkgo, Radix Inulae Nervosae, Pu Gong English, Rhizoma Begoniae Fimbristipulatae, Radix Linderae Glaucae, tingia Farfugium kaemferi, Ganoderma, Herba Violae diamantiacae, Semen Oroxyli, the Radix Stemonae, Flos Lonicerae, Herb Gynostemmae Pentaphylli, Stachys palustris L., hair Leaf Chinese photinia, Fructus Lycii, hilllock Eurya plant, three marks, shamrock, Herba Scindapsi Officinalis, Herba Bulbophylli inconspicui, Herba youngiae japonicae and Radix ceratostigmatis willemottiani.
In described medicine, the parts by weight of each raw medicinal material are: Radix ardisiae japonicae 12-24 weight portion, Radix Cudraniae 10-30 weight Part, flower 14-26 weight portion, Herba Cichorii 15-35 weight portion, Semen Ginkgo 2-4 weight portion, Radix Inulae Nervosae 11-21 weight portion, Herba Taraxaci 13- 23 weight portions, Rhizoma Begoniae Fimbristipulatae 14-28 weight portion, Radix Linderae Glaucae 15-35 weight portion, tingia Farfugium kaemferi 12-22 weight portion, Ganoderma 10-40 Weight portion, Herba Violae diamantiacae 13-31 weight portion, Semen Oroxyli 14-28 weight portion, Radix Stemonae 3-5 weight portion, Flos Lonicerae 14-22 weight portion, strand Stock blue 15-35 weight portion, Stachys palustris L. 12-24 weight portion, hair leaf Chinese photinia 7-14 weight portion, Fructus Lycii 9-18 weight portion, hilllock Eurya plant 15-25 weight portion, three marks 12-24 weight portion, shamrock 14-32 weight portion, Herba Scindapsi Officinalis 11-21 weight portion, Herba Bulbophylli inconspicui 14-34 Weight portion, Herba youngiae japonicae 10-20 weight portion and Radix ceratostigmatis willemottiani 15-35 weight portion.
In described medicine, the parts by weight of each raw medicinal material are: Radix ardisiae japonicae 14-22 weight portion, Radix Cudraniae 10-30 weight Part, flower 15-25 weight portion, Herba Cichorii 15-35 weight portion, Semen Ginkgo 2-3 weight portion, Radix Inulae Nervosae 12-20 weight portion, Herba Taraxaci 14- 22 weight portions, Rhizoma Begoniae Fimbristipulatae 14-26 weight portion, Radix Linderae Glaucae 15-35 weight portion, tingia Farfugium kaemferi 12-20 weight portion, Ganoderma 10-40 Weight portion, Herba Violae diamantiacae 13-30 weight portion, Semen Oroxyli 14-28 weight portion, Radix Stemonae 3-4 weight portion, Flos Lonicerae 15-20 weight portion, strand Stock blue 15-35 weight portion, Stachys palustris L. 14-22 weight portion, hair leaf Chinese photinia 7-13 weight portion, Fructus Lycii 9-16 weight portion, hilllock Eurya plant 15-25 weight portion, three marks 12-22 weight portion, shamrock 15-32 weight portion, Herba Scindapsi Officinalis 12-20 weight portion, Herba Bulbophylli inconspicui 15-32 Weight portion, Herba youngiae japonicae 10-20 weight portion and Radix ceratostigmatis willemottiani 15-35 weight portion.
In described medicine, the parts by weight of each raw medicinal material are: Radix ardisiae japonicae 15-22 weight portion, Radix Cudraniae 10-30 weight Part, flower 15-23 weight portion, Herba Cichorii 15-35 weight portion, Semen Ginkgo 2-3 weight portion, Radix Inulae Nervosae 12-20 weight portion, Herba Taraxaci 14- 22 weight portions, Rhizoma Begoniae Fimbristipulatae 14-25 weight portion, Radix Linderae Glaucae 15-35 weight portion, tingia Farfugium kaemferi 12-20 weight portion, Ganoderma 10-40 Weight portion, Herba Violae diamantiacae 15-30 weight portion, Semen Oroxyli 14-26 weight portion, Radix Stemonae 3-4 weight portion, Flos Lonicerae 16-20 weight portion, strand Stock blue 15-32 weight portion, Stachys palustris L. 14-20 weight portion, hair leaf Chinese photinia 8-12 weight portion, Fructus Lycii 9-15 weight portion, hilllock Eurya plant 15-25 weight portion, three marks 12-21 weight portion, shamrock 18-32 weight portion, Herba Scindapsi Officinalis 12-20 weight portion, Herba Bulbophylli inconspicui 16-30 Weight portion, Herba youngiae japonicae 10-20 weight portion and Radix ceratostigmatis willemottiani 15-33 weight portion.
In described medicine, the parts by weight of each raw medicinal material are: Radix ardisiae japonicae 17 weight portion, Radix Cudraniae 20 weight portion, flower 22 weight portions, Herba Cichorii 32 weight portion, Semen Ginkgo 2 weight portion, Radix Inulae Nervosae 14 weight portion, Herba Taraxaci 19 weight portion, Rhizoma Begoniae Fimbristipulatae 22 weight Part, Radix Linderae Glaucae 32 weight portion, tingia Farfugium kaemferi 15 weight portion, Ganoderma 30 weight portion, Herba Violae diamantiacae 20 weight portion, Semen Oroxyli 15 weight Part, the Radix Stemonae 3 weight portion, Flos Lonicerae 17 weight portion, Herb Gynostemmae Pentaphylli 30 weight portion, Stachys palustris L. 16 weight portion, hair leaf Chinese photinia 12 weight Part, Fructus Lycii 14 weight portion, hilllock Eurya plant 23 weight portion, three marks 12 weight portions, shamrock 30 weight portion, Herba Scindapsi Officinalis 15 weight Part, Herba Bulbophylli inconspicui 18 weight portion, Herba youngiae japonicae 10 weight portion and Radix ceratostigmatis willemottiani 32 weight portion.
In described medicine, the parts by weight of each raw medicinal material are: Radix ardisiae japonicae 21 weight portion, Radix Cudraniae 19 weight portion, flower 22 weight portions, Herba Cichorii 32 weight portion, Semen Ginkgo 2 weight portion, Radix Inulae Nervosae 16 weight portion, Herba Taraxaci 20 weight portion, Rhizoma Begoniae Fimbristipulatae 16 weight Part, Radix Linderae Glaucae 32 weight portion, tingia Farfugium kaemferi 18 weight portion, Ganoderma 30 weight portion, Herba Violae diamantiacae 25 weight portion, Semen Oroxyli 22 weight Part, the Radix Stemonae 3 weight portion, Flos Lonicerae 17 weight portion, Herb Gynostemmae Pentaphylli 28 weight portion, Stachys palustris L. 15 weight portion, hair leaf Chinese photinia 10 weight Part, Fructus Lycii 13 weight portion, hilllock Eurya plant 24 weight portion, three marks 15 weight portions, shamrock 30 weight portion, Herba Scindapsi Officinalis 16 weight Part, Herba Bulbophylli inconspicui 24 weight portion, Herba youngiae japonicae 15 weight portion and Radix ceratostigmatis willemottiani 32 weight portion.
In described medicine, the parts by weight of each raw medicinal material are: Radix ardisiae japonicae 20 weight portion, Radix Cudraniae 30 weight portion, flower 21 weight portions, Herba Cichorii 19 weight portion, Semen Ginkgo 3 weight portion, Radix Inulae Nervosae 16 weight portion, Herba Taraxaci 21 weight portion, Rhizoma Begoniae Fimbristipulatae 23 weight Part, Radix Linderae Glaucae 32 weight portion, tingia Farfugium kaemferi 16 weight portion, Ganoderma 35 weight portion, Herba Violae diamantiacae 25 weight portion, Semen Oroxyli 22 weight Part, the Radix Stemonae 4 weight portion, Flos Lonicerae 18 weight portion, Herb Gynostemmae Pentaphylli 30 weight portion, Stachys palustris L. 16 weight portion, hair leaf Chinese photinia 10 weight Part, Fructus Lycii 13 weight portion, hilllock Eurya plant 22 weight portion, three marks 14 weight portions, shamrock 30 weight portion, Herba Scindapsi Officinalis 15 weight Part, Herba Bulbophylli inconspicui 20 weight portion, Herba youngiae japonicae 15 weight portion and Radix ceratostigmatis willemottiani 32 weight portion.
Described preparation method comprises the following steps: is all put in pulverizer by described raw medicinal material and is ground into fine powder, puts Enter acid and alkali-resistance infusion kettle, the ethanol that determining alcohol is 80%-90% relative to 3-5 times of fine powder quality is poured in pot, at room temperature Under normal pressure, impregnating 20-30 days, the liquid impregnated and dregs pressing are filtered subsequently, filtrate reduced in volume obtains paste, puts into Oven for drying, the temperature of oven drying is 110-115 DEG C, 10-20 minute drying time, grinds to form 150-250 mesh thin after drying Powder so that it is fine powder amount reaches more than 95% always expected, obtains described medicine.
The invention has the beneficial effects as follows: the Drug therapy dog pneumonia of the present invention is by anti-inflammation, expelling phlegm for arresting cough, profit Larynx, can play efficiency high, and determined curative effect reduces mortality rate, and cure rate is high, has no side effect, relative to conventional medicament in treatment In effect, have that healing time is short, short treating period, good effect, the features such as safety is high, with strong points.
Detailed description of the invention
The present invention provides a kind of pharmaceutical composition treating Infectious Tracheobroncheitis, and described pharmaceutical composition includes following Raw medicinal material: Radix ardisiae japonicae, Radix Cudraniae, flower, Herba Cichorii, Semen Ginkgo, Radix Inulae Nervosae, Herba Taraxaci, Rhizoma Begoniae Fimbristipulatae, Radix Linderae Glaucae, tingia bag I, Ganoderma, Herba Violae diamantiacae, Semen Oroxyli, the Radix Stemonae, Flos Lonicerae, Herb Gynostemmae Pentaphylli, Stachys palustris L., hair leaf Chinese photinia, Fructus Lycii, hilllock Eurya plant, three Mark, shamrock, Herba Scindapsi Officinalis, Herba Bulbophylli inconspicui, Herba youngiae japonicae and Radix ceratostigmatis willemottiani.
The characteristic of above-mentioned raw materials medical material is as follows:
Radix ceratostigmatis willemottiani: another name: seven-star arrow [Sichuan].Source: lumbaginaceae Ceratostigma platymiscium Radix ceratostigmatis willemottiani Ceratostigma Willmottianum Stapf and ceratostigma plumbaginoides Bunge C. plumbaginoides Bunge, is used as medicine with root.Xia Qiu gathers, and dries.Property Taste: sweet, acrid, warm.Cure mainly: spasmolytic, analgesia.The pain caused for gastritis, gastric ulcer, ascariasis of biliary tract, cholecystitis and ascariasis Bitterly.
Shamrock: another name: Herba Cucubali [Kunming].Source: pulse family clover shamrock Medicago Lupulina L., with all herbal medicine.Xia Qiucai, cleans and dries.Nature and flavor: sweet, micro-puckery are flat.Curing mainly: clearing away heat-damp and promoting diuresis, removing heat from blood is only Blood, relaxing muscles and tendons and activating QI and blood in the collateral.For icterohepatitis, have blood in stool, bleeding hemorrhoids, leukemia, sciatica, rheumatic ostalgia, lumbar muscle strain. Venom is controlled in external.
Hilllock Eurya plant: another name: Hex godajam (colebr) Wall, Formica fusca wood.Source: Theaceae hilllock Eurya plant Eurya groffii Merr., is used as medicine with leaf. Nature and flavor: micro-hardship are flat.Cure mainly: eliminating phlegm antitussive, reducing swelling and alleviating pain.Cure mainly pulmonary tuberculosis, cough.Treating swelling and pain by traumatic injury is controlled in external.
Hair leaf Chinese photinia: another name: Oryza glutinosa pearl, Deng Xiangguan.Source: Rosaceae hair leaf Chinese photinia Photinia villosa (Thunb.) DC., is used as medicine with root, fruit.Nature and flavor: bitter are flat.Cure mainly: dehumidifying heat, emesis rushes down.Control vomiting and dirarrhea, dysentery, extensive Multiple fatigue.
Herba Violae diamantiacae: source: " Shaanxi Chinese herbal medicine ".Another name: big Herba violae patrinii.Source: complete for common violet kind plant great Ye common violet Grass.Late summer gathers, and cleans, dries in the shade or using fresh herb.Nature and flavor: bitter in the mouth is pungent, cool in nature.Cure mainly: heat-clearing and toxic substances removing, hemostasis.Control furuncle toxic swelling, wheat Grain is swollen, venom, traumatic hemorrhage, pulmonary tuberculosis.
Tingia Farfugium kaemferi: another name: rescue greatly, ligularia dentata Hara.Source: Compositae tingia Farfugium kaemferi Ligularia dentata (A. Gray) Hara, is used as medicine with root.Nature and flavor: pungent, tepor.Cure mainly: relaxing muscles and tendons to promote blood circulation, eliminating stasis to stop pain.Cure mainly traumatic injury, pain.
The Radix Stemonae: another name: Radix Stemonae, Herba delphinii grandiflori, noisy louse medicine, medicine louse medicine.Source: this product is Stemonaceae plant Radix Stemonae Stemona sessilifolia (Miq.) Miq., Radix stemonae japonicae Stemona japonica (Bl.) Miq. or to leaf hundred The dried root of portion Stemona tuberosa Lour..Spring, season in autumn two excavate, and remove fibrous root, clean, put in boiling water boiling the hottest Or steam to without the white heart, take out, dry.Nature and flavor: sweet, bitter, tepor.Gui Jing: return lung meridian.Slightly poisonous.Cure mainly: nourishing the lung to keep the adverse QI downward cough-relieving, Parasite killing.Cough for new chronic cough, pulmonary tuberculosis cough, pertussis；Outer for head louse, body louse, enterobiasis, pudendal pruritus.Honey Radix Stemonae nourishing the lung to arrest cough. For deficiency of YIN chronic cough.
Rhizoma Begoniae Fimbristipulatae: source: " wide conventional medicament plants register ".Another name: Radix Semiaquilegiae, red autumnal leaves, scattered blood, dragon and tiger leaf (" propagation Register planted by system medicine "), cross water certain herbaceous plants with big flowers red, red (" Guangxi practicality Chinese herbal medicine newly selects ") night.Source: carry on the back sky for Begoniaceae plant purple The bulb of certain herbaceous plants with big flowers or Herb.Spring, summer gather, and dry.Nature and flavor: sweet are cool.1. Guangzhou army " conventional Chinese herbal medicine handbook ": " sweet light, Cool." 2. " conventional Chinese herbal medicine color atlas ": " is sweet puckery, cool, nontoxic." 3. " Guangxi practicality Chinese herbal medicine newly selects ": " is sour and astringent, cool in nature." Cure mainly: clearing away heat and cooling blood, promoting blood circulation and detoxication.Control summer-heat hyperpyrexia, cough due to lung-heat, spitting of blood, osteopatia sprain, blood stasis pain, sore scabies, water Burning hot wound.1. Guangzhou army " conventional Chinese herbal medicine handbook ": " heat-clearing and toxic substances removing, moistens dryness and relieve cough, dissipating blood stasis for subsidence of swelling.Control exogenous high fever.Heatstroke Fever, cough due to lung-heat, treating swelling and pain by traumatic injury.Fresh goods is mashed, and can apply malignant boil furunculosis." 2. " conventional Chinese herbal medicine color atlas ": " controls pneumonia Cough, spitting of blood, chronic bronchitis." 3. " Guangxi practicality Chinese herbal medicine newly selects ": " removing heat from blood and promoting blood circulation, anti-inflammatory analgetic.Cure mainly spitting of blood, blood The stasis of blood is suffered from abdominal pain, bruise, fracture, burn, tinea scabies."
Semen Ginkgo: another name: Semen Ginkgo core.Source: this product is Ginkgoaceae plant Ginkgo biloba (maidenhair tree, Gong Sunshu) Ginkgo biloba L. Dry mature seed.Gather during seed maturity in autumn, remove meat episperm, clean, after slightly steaming or slightly boil, dry.Nature and flavor: Sweet, bitter, puckery, flat；Poisonous.Gui Jing: return lung meridian.Curing mainly: astringing lung QI for relieving asthma, leukorrhagia stopping is turbid, urine reducing.Breathing with cough for abundant expectoration, leukorrhagia is white Turbid, enuresis frequent micturition.
Radix Cudraniae: another name: sesame, golden cicada ejection, HUANGLONG ejection, lead a cow into stone, Flos Wikstroemiae Nutantis, Radix Cudraniae, mountain Fructus Litchi, thousandweight Skin.Source: Moraceae three-bristle cudrania platymiscium cudrania cochinchinensis Cudrania cochin chinensis (Lour.) Kudo et Masam., with root It is used as medicine.The whole year can adopt, and clean section is dried.Congener Zhe Shu (Ci Sang) Cudrania tricuspidata (Carr.) Bur..Effect is roughly the same with front kind.Nature and flavor: micro-hardship are flat.Cure mainly: relieving cough and resolving phlegm, expelling wind and removing dampness, eliminating stasis to stop pain.Tie for lung Core, icterohepatitis, hepatosplenomegaly, taste-blindness rate, rheumatic lumbago and scelalgia；Fracture, traumatic injury are controlled in external.
Radix Inulae Nervosae: source: " the southern regions of the Yunnan Province book on Chinese herbal medicine ".Another name: Radix Saniculae Astrantifoliae, Radix Clematidis (" the southern regions of the Yunnan Province book on Chinese herbal medicine "), (" Guizhou is among the people for black root Medicine "), grass Radix Clematidis (" Kunming conventional medical herbs among the people "), copper foot Wei spirit (" choosing of Yunnan Chinese herbal medicine "), black Wheeling, ferrum foot Wheeling (" choosing of Simao, Yunnan Chinese herbal medicine "), Radix vernoniae asperae, little black root (" Economic In Yunnan plant ").Source: for feverfew Inula Narvosa Root.Autumn excavates, and cleans cutting, dries.Nature and flavor: 1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " acrid in the mouth is bitter, warm in nature." 2. " Guizhou Folk medicine Thing ": " acrid-sweet flavor, warm in nature." curing mainly: cold-dispelling, removing food stagnancy is stagnant, the meridian dredging.Control coldness and pain in the epigastrium, dyspeptic abdominal distention, dysphagic, stomachache, body Empty hyperhidrosis, cold cough, rheumatism tinea pedis.1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " controlling cold shut pain due to disorder of QI in chest and diaphragm, whet the appetite gas, can control dysphagic, cold-damp Muscle and tendon injury bone, only beriberi caused by pathogenic damp.Liquor decoction, chronic infantile convulsion due to dysfunction of the spleen of dispelling." 2. " Guizhou folk medicine ": " fills blood, hidroschesis." 3. " Yunnan Chinese herbal medicine Choosing ": " wind-damp dispelling, the meridian dredging, removing food stagnancy pain relieving.Treating rheumatic arthritis, lumbago and skelalgia, stomachache, dyspepsia, a fishbone or other bone caught in the throat larynx." 4. " cloud The Chinese herbal medicine choosing of Simao, south ": " diuretic dehumidifies, eliminating phlegm and stopping cough.Cure cold, cough, high heat."
Flower: source: come from " Jilin Chinese herbal medicine ".Another name: electric light flower.Source: medical material Ji Yuan: for flower section vegetable silk flower Root and rhizome.Latin plant animal mineral name: 1.Polemonium coeruleum L. [P. laxi-florum (Regel)Kitamura;P. racemosum (Regel) Kitamura]2.Polemonium liniflorum V.Vassil. gather and store: autumn gathers, cleaning earth, dry.Nature and flavor: bitter；Flat.Gui Jing: lung；The heart；Liver；Spleen；Stomach warp. Cure mainly: reduce phlegm；Calm the nerves；Hemostasis.Main cough with copious phlegm；Epilepsy；Insomnia；Spitting of blood；Nosebleed song；Spit blood；Have blood in stool；Menorrhagia
Radix Linderae Glaucae: source: come from " Fujian traditional herbal medicine ".Another name: ox tendon strip root, root of Lindera glauca (Sieb. Et Zucc.) Blume, Thunder God height, red autumnal leaves bavin, Huang Gold toothed oak.Source: medical material Ji Yuan: for the root of canella Fructus Linderae Glaucae.Latin plant animal mineral name: Lindera glauca (Sieb.et Zucc.) Bl. gathers and stores: autumn gathers, and dries.Nature and flavor: pungent；Temperature；Bitter.Gui Jing: liver；Stomach warp.Cure mainly: Dispelling wind and removing obstruction in the collateral；Vital energy regualting and blood circulation-promoting；Inducing diuresis and reducing edema；Preventing phlegm from forming and stopping coughing.Main air pain of dampness syndrome；Traumatic injury；Gastralgia；De-power impairment caused by overstrain；? Tracheitis；Edema
Three marks: another name: three plumage crescent Herba pteridii latiusculis, Herba pronephrii triphylli, Rhizoma Helminthostachydis Zeylanicae.Source: fern Athyriaceae three plumage crescent Herba pteridii latiusculi Abacopteris triphylla (Sw.) Ching, with all herbal medicine.Nature and flavor: micro-sweet, pungent are flat.Cure mainly: dissipate poison detumescence, clearly Transconversion into heat expectorant.Cure mainly venom, traumatic injury, eczema, dermatitis, ulcerative carbuncle furuncle and phyma, acute/chronic bronchitis.
Semen Oroxyli: source: this product is being dried to of Bignoniaceae plant oroxylum indicum Oroxylum indicum (L.) Vent. Ripe seed.Autumn, mature fruit of gathering in season in winter two, tan by the sun to cracking of fruit, take out seed, dry.Nature and flavor: bitter, sweet are cool.Gui Jing: Return lung, liver, stomach warp.Cure mainly: removing heat from the lung and relieving sorethroat, dispersing the stagnated liver-QI for regulating the stomach.For cough due to lung-heat, sore throat, hoarseness, stomachache due to hyperactive liver-QI attacking the stomach.
Herb Gynostemmae Pentaphylli: another name: Herba Gynostemmatis, Herba Gynostemmatis, Herb Gynostemmae Pentaphylli.Source: cucurbitaceae genus gynostemma Herb Gynostemmae Pentaphylli Gynostemma pentaphyllum (Thunb.) Makino, is used as medicine with root stock.Autumn gathers, and cleans and dries, levigation.Property Taste: bitter, cold.Cure mainly: heat-clearing and toxic substances removing, eliminating phlegm and stopping cough.For chronic bronchitis, infectious hepatitis, nephritis is scorching, gastroenteritis.
Herba youngiae japonicae: another name: hair repeatedly, wild mustard [Fujian], Hemerocallis citrina Baroni branch Rhizoma et radix valerianae, wild green vegetable.Source: Compositae Youngia is planted Thing Herba youngiae japonicae Youngia japonica (L.) DC. [Crepis japonica (L.) Benth.], enters with herb or root Medicine.The four seasons can adopt, and cleans, using fresh herb or dry.Nature and flavor: hardship sweet, micro-are cool.Cure mainly: heat-clearing and toxic substances removing, inducing diuresis to remove edema, pain relieving.For Pharyngitis, mastitis, toothache, dysuria, cirrhotic ascites；Furuncle toxic swelling is controlled in external.
Stachys palustris L.: source: " Zhejiang conventional medical herbs among the people ".Another name: Wangjiang is blue or green, sky Semen Sesami (" Li Shi grass is secret "), Baima Orchid, mud lampwick, wild country silkworm, Bletilla striata (Thunb.ex A.Murray)Rchb.f. grass (" Zhejiang conventional medical herbs among the people ").Source: for the root or complete of labiate Stachys palustris L. Grass.Spring gathered to early winter.Nature and flavor: " Wenling county drug resource register ": " taste is micro-sweet, and property is put down." cure mainly: removing heat-phlegm, antibacterial Antiinflammatory.Control cough due to pathogenic wind-heat, laryngopharynx swelling and pain, pertussis, dysentery, herpes zoster.1. " will planted by Hangzhou medicine ": " de-power analeptic."② " Zhejiang conventional medical herbs among the people ": " anti-inflammation." 3. " Wenling county drug resource register ": " tonifying YIN relieves inflammation or internal heat, expectorant of purging heat.Control wind Heat rises, laryngopharynx swelling and pain, cough, aphonia, herpes herpes simplex."
Herba Cichorii: source: this strain Uygur nationality conventional crude drugs.For feverfew saussurea intybus Cichorium glandulosum Boiss.et Hout and the aerial parts of Herba Cichorii Cichorium intybus L..Autumn taps, and removes impurity, dries.Property Taste: micro-hardship, salty is cool.Cure mainly: liver heat removing function of gallbladder promoting, invigorating the stomach and promoting digestion, inducing diuresis to remove edema.For jaundice due to damp-heat, lack of appetite of having a stomachache, edema oliguria.
Radix ardisiae japonicae: source: " Bencao Tujing ".Source: for the root of Radix ardisiae japonicae section plant Radix ardisiae japonicae, can adopt the whole year, Clean, dry.Nature and flavor: pungent are flat.1. " Bencao Tujing ": " acrid in the mouth." 2. " detailed outline ": " is pungent, flat, nontoxic." cure mainly: 1. " this sketch Warp ": " disease diaphragm gas time main, goes wind-phlegm to use it." 2. " detailed outline ": " removing toxic substances removing blood stasis." 3. " Traditional Chinese Medicine in Sichuan will ": " controls cold air stomachache." Radix ardisiae japonicae Radix ardisiae japonicae Radix ardisiae japonicae Herba Scindapsi Officinalis: another name: Jin Zhubiao, little Nan Soviet Union, great Nan Soviet Union, little Cortex Ampelopsis Aconitifoliae Radicis, climb that rock is imperial, climb tree Dragon.Source: Araeceae Scindapsus plant Herba Scindapsi Officinalis Scindapsus officinalis Schott, is used as medicine with Herb.The four seasons Can adopt, clean, dry.Nature and flavor: bitter, cold.Cure mainly: clearing away lung-heat to relieve cough, reunion of fractured tendons and bones.For upper respiratory tract infection, bronchitis, hundred Day is coughed, angina pectoris, traumatic injury, fracture, bones and muscles pain.
Herba Bulbophylli inconspicui: another name: Herba Bulbophylli Odoratissim, Shi Dou, extension fish, a sheep milk leaf Herba Bulbophylli radiati careless, Dracocephalum moldabium, single.Source: belong to for the orchid family Bulbophyllum Plant Herba Bulbophylli inconspicui Bulbophyllum inconspicuum Maxim., with all herbal medicine.The whole year can adopt, and cleans and shines after drying or steaming Dry standby.Nature and flavor: sweet, light are cool.Cure mainly: nourishing YIN and clearing away heat, preventing phlegm from forming and stopping coughing.For xeropulmonary cough, hemoptysis of pulmonary tuberculosis, calentura excessive thirst, Tonsillitis.
Ganoderma: another name: Ganoderma lucidum seu Japonicum, Ganoderma, Ganoderma Lucidum.Source: this product is On Polyporaceae Ganoderma lucidum (Leyss. Ex Fr.) Karst. Ganoderma Lucidum(Leyss.ex Fr.) the dry son of Karst. or Ganoderma Ganoderma sinense Zhao, Xu et Zhang is real Body.The whole year gathers, and removes impurity, wipes out the lower end stem with rotten wood, silt or culture matrix, dry in the shade or 40～50 DEG C of bakings Dry.Nature and flavor: sweet are flat.Gui Jing: GUIXIN, lung, liver, kidney channel.Cure mainly: invigorating QI and tranquilization, relieving cough and asthma.For dizziness sleeplessness, cardiopalmus gas Short, asthenia cough with asthma.
Herba Taraxaci: another name: Herba crotalariae albidae, Po Poding.Source: this product is feverfew Herba Taraxaci Taraxacum Mongolicum Hand.-Mazz., alkali ground Herba Taraxaci Taraxacum sinicum Kitag. or belong to the dry of several plants together Dry herb.Spend spring to autumn and excavate when just opening, remove impurity, clean, dry.Nature and flavor: bitter, sweet, cold.Gui Jing: return liver, stomach warp. Cure mainly: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome.For furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, wet Hot jaundice, the puckery pain of pyretic stranguria.
Flos Lonicerae: another name: Flos Lonicerae, Flos Lonicerae, Flos Lonicerae, two precious flowers.Source: this product is caprifoliaceae plant Radix Ophiopogonis Lonicera Japonica Thunb., Flos Lonicerae Lonicera hypoglauca Miq., Flos Lonicerae (hair calyx Radix Ophiopogonis) Lonicera The flower that confusa DC. or the dry flower of hair style Radix Ophiopogonis Lonicera dasystyla Rehd. or band just open.Early summer flower Gather before opening, be dried.Nature and flavor: sweet, cold.Gui Jing: return lung, the heart, stomach warp.Cure mainly: heat-clearing and toxic substances removing, wind-heat dissipating.For carbuncle Furuncle, sore throat, erysipelas, toxic-heat and blood stasis, anemopyretic cold, epidemic febrile disease is generated heat.
Fructus Lycii: source: this product is the dry mature fruit of plant of Solanaceae lycium barbarum Lycium barbarum L.. Summer, season in autumn two fruit are gathered when taking on a red color, hot-air seasoning, remove carpopodium.Or dry in the air to rhicnosis, dry, remove carpopodium.Nature and flavor: Sweet, flat.Gui Jing: return liver, kidney channel.Cure mainly: nourishing the liver and kidney, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior Heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand.
Hereinafter using embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve whereby Certainly technical problem, and the process that realizes reaching technique effect can fully understand and implement according to this.
Embodiment 1 medicine 1
Embodiments provide a kind of pharmaceutical composition treating Infectious Tracheobroncheitis, former by following parts by weight Material medical material is made: Radix ardisiae japonicae 17 weight portion, Radix Cudraniae 20 weight portion, spend 22 weight portions, Herba Cichorii 32 weight portion, Semen Ginkgo 2 weight Amount part, Radix Inulae Nervosae 14 weight portion, Herba Taraxaci 19 weight portion, Rhizoma Begoniae Fimbristipulatae 22 weight portion, Radix Linderae Glaucae 32 weight portion, tingia Farfugium kaemferi 15 Weight portion, Ganoderma 30 weight portion, Herba Violae diamantiacae 20 weight portion, Semen Oroxyli 15 weight portion, the Radix Stemonae 3 weight portion, Flos Lonicerae 17 weight portion, Herb Gynostemmae Pentaphylli 30 weight portion, Stachys palustris L. 16 weight portion, hair leaf Chinese photinia 12 weight portion, Fructus Lycii 14 weight portion, hilllock Eurya plant 23 weight portion, Three mark 12 weight portions, shamrock 30 weight portion, Herba Scindapsi Officinalis 15 weight portion, Herba Bulbophylli inconspicui 18 weight portion, Herba youngiae japonicae 10 weight portion and Radix ceratostigmatis willemottiani 32 weight portion.
Said medicine is to be prepared by following preparation method: is all put in pulverizer by described raw medicinal material and is ground into carefully Powder, puts into acid and alkali-resistance infusion kettle, pours in pot, the ethanol that determining alcohol is 85% relative to 3.5 times of fine powder quality at room temperature into Under normal pressure, impregnating 25 days, the liquid impregnated and dregs pressing are filtered subsequently, filtrate reduced in volume obtains paste, puts into baking Case is dried, and the temperature of oven drying is 110 DEG C, 15 minutes drying times, grinds to form 180 mesh fine powders so that it is fine powder amount after drying Reach more than 95% always expected, obtain described medicine.
Embodiment 2 medicine 2
Embodiments provide a kind of pharmaceutical composition treating Infectious Tracheobroncheitis, former by following parts by weight Material medical material is made: Radix ardisiae japonicae 21 weight portion, Radix Cudraniae 19 weight portion, spend 22 weight portions, Herba Cichorii 32 weight portion, Semen Ginkgo 2 weight Amount part, Radix Inulae Nervosae 16 weight portion, Herba Taraxaci 20 weight portion, Rhizoma Begoniae Fimbristipulatae 16 weight portion, Radix Linderae Glaucae 32 weight portion, tingia Farfugium kaemferi 18 Weight portion, Ganoderma 30 weight portion, Herba Violae diamantiacae 25 weight portion, Semen Oroxyli 22 weight portion, the Radix Stemonae 3 weight portion, Flos Lonicerae 17 weight portion, Herb Gynostemmae Pentaphylli 28 weight portion, Stachys palustris L. 15 weight portion, hair leaf Chinese photinia 10 weight portion, Fructus Lycii 13 weight portion, hilllock Eurya plant 24 weight portion, Three mark 15 weight portions, shamrock 30 weight portion, Herba Scindapsi Officinalis 16 weight portion, Herba Bulbophylli inconspicui 24 weight portion, Herba youngiae japonicae 15 weight portion and Radix ceratostigmatis willemottiani 32 weight portion.
Said medicine is to be prepared by following preparation method: is all put in pulverizer by described raw medicinal material and is ground into carefully Powder, puts into acid and alkali-resistance infusion kettle, is poured in pot by the ethanol that determining alcohol is 80% relative to 5 times of fine powder quality, normal at room temperature Pressure, impregnates 20 days, the liquid impregnated and dregs pressing is filtered subsequently, and filtrate reduced in volume obtains paste, puts into baking oven Drying, the temperature of oven drying is 115 DEG C, 18 minutes drying times, grinds to form 220 mesh fine powders so that it is fine powder amount reaches after drying To more than the 95% of total material, obtain described medicine.
Embodiment 3 medicine 3
Embodiments provide a kind of pharmaceutical composition treating Infectious Tracheobroncheitis, former by following parts by weight Material medical material is made: Radix ardisiae japonicae 20 weight portion, Radix Cudraniae 30 weight portion, spend 21 weight portions, Herba Cichorii 19 weight portion, Semen Ginkgo 3 weight Amount part, Radix Inulae Nervosae 16 weight portion, Herba Taraxaci 21 weight portion, Rhizoma Begoniae Fimbristipulatae 23 weight portion, Radix Linderae Glaucae 32 weight portion, tingia Farfugium kaemferi 16 Weight portion, Ganoderma 35 weight portion, Herba Violae diamantiacae 25 weight portion, Semen Oroxyli 22 weight portion, the Radix Stemonae 4 weight portion, Flos Lonicerae 18 weight portion, Herb Gynostemmae Pentaphylli 30 weight portion, Stachys palustris L. 16 weight portion, hair leaf Chinese photinia 10 weight portion, Fructus Lycii 13 weight portion, hilllock Eurya plant 22 weight portion, Three mark 14 weight portions, shamrock 30 weight portion, Herba Scindapsi Officinalis 15 weight portion, Herba Bulbophylli inconspicui 20 weight portion, Herba youngiae japonicae 15 weight portion and Radix ceratostigmatis willemottiani 32 weight portion.
Said medicine is to be prepared by following preparation method: is all put in pulverizer by described raw medicinal material and is ground into carefully Powder, puts into acid and alkali-resistance infusion kettle, is poured in pot by the ethanol that determining alcohol is 90% relative to 4 times of fine powder quality, normal at room temperature Pressure, impregnates 28 days, the liquid impregnated and dregs pressing is filtered subsequently, and filtrate reduced in volume obtains paste, puts into baking oven Drying, the temperature of oven drying is 115 DEG C, 20 minutes drying times, grinds to form 150 mesh fine powders so that it is fine powder amount reaches after drying To more than the 95% of total material, obtain described medicine.
Toxicity test
1, cumulative toxicity test report
Select 30 healthy mices, female, male each 10, with the medicine of the embodiment of the present invention 1 as object, every 7 days of dose design Being a phase, each issue dosage is respectively 0.10LD50,0.20LD50,0.25LD50,0.30LD 50,0.40LD50, this sample The LD 50 female, male mice of product be 4000m part/k part BW (five dosage is 500,750,1100,1800,2400m Part/k part BW).Within every 7 days, weigh once, adjust dosage, by 0.05ml/10 part BW per os gavage.After 28 days, animal is without extremely Situation of dying occurs, off-test, by ascending-dose to tested material 28 days after, female, buck is all without death condition generation.With Embodiment 2, the medicine of embodiment 3 are object, carry out toxicity test according to the method described above, and result such as embodiment 1 is identical.
2, acute toxicity test
Application NIH mice 40, SPF level, male and female half and half, body weight 15～20g, carry out acute toxicity test.Mice is randomly divided into Two groups, often group 20, i.e. matched group and administration group, fasting 12 hours before experiment；The medicine prepared by embodiments of the invention 1 is molten In Xie Shui, (concentration is 6.75g crude drug/ml, maximum concentration) gavage, gavage volume is that 7ml/kg(i.e. unit dosage form is 28.7 crude drugs/kg), matched group gives normal saline, within one day, is administered 3 times, delivery time 8 hours, after administration continuously Observe 14 days, and record toxic reaction and the death toll of mice.Test result indicate that: compare with matched group, after administration, mice is not Seeing notable difference, experiment Continuous Observation 21 days, mouse systemic situation, diet, drinking-water, body weight increase the most normal.Therefore the present invention The acute toxicity of the medicine of embodiment 1 is low, clinical drug safety.Respectively with the medicine of embodiment 2 and embodiment 3 as object, press Carrying out toxicity test according to said method, result such as embodiment 1 is identical.
Clinical symptoms: mainly present laryngitis, tracheitis, bronchitis, tonsillitis and symptoms of pneumonia, clinical manifestation weight Differing, the Symptoms of pup generally ratio is more serious.There is the most suddenly paroxysmal dry cough in sick dog, then occurs retching or feeling sick, Serious may occur in which rhinorrhea, flows outwardly more nose liquid, antiadoncus, anorexia with breathing.Some dogs performance paroxysmal is breathed Difficulty, vomit or diarrhoea etc..The course of disease extends, sick dog down in spirits, loss of appetite, muscular tremor, finally can develop into pneumonia, exhale Suction is urged, visual mucosa cyanosis, is easily caused death.
Curative effect diagnostic criteria:
Cure: symptom, sign, virus purification and Serological testing are the most normal；
Effective: symptom, sign, virus purification and Serological testing are clearly better, but three have one recover normal the most completely；
Effective: after medication, the state of an illness has taken a turn for the better；
Invalid: after medication, the state of an illness is without being clearly better or adding severe one.
Treatment contrast test:
In December, 2014 in December ,-2015, has 400 dogs suffering from infectious bronchitis, and 400 dogs are randomly divided into four Group, respectively embodiment 1 group, embodiment 2 groups, embodiment 3 groups and matched group, use the prepared medicine 1 of embodiment 1, reality respectively Execute medicine 2 that example 2 prepares, medicine 3 that embodiment 3 prepares carries out treating and matched group is treated, wherein, and embodiment 1 group-3 Dose be every every day 0.3g be uniformly blended in basal diet, be 10-20 days during treatment；Matched group selects tetracycline 15mg/kg body weight, erythromycin 0.1mg/kg body weight, it is dissolved in 5% glucose, intravenous injection, 2 times/day, treats 10-20 days.Control Treatment is observed three months after terminating, and records cure rate and the mortality rate of each group of dog, and result is as shown in table 1.
Therapeutic outcome:
See Tables 1 and 2, as it can be seen from table 1 use the medicine composite for curing Infectious Tracheobroncheitis of the present invention, phase For conventional medicament on therapeutic effect, have and be markedly improved；From table 2 it can be seen that use the pharmaceutical composition of the present invention Treatment Infectious Tracheobroncheitis, relative to conventional medicament, significantly shortens on the course for the treatment of treating.
Table 1 each experimental group therapeutic effect synopsis
Group Number of cases Cure number Cure rate (%) Significant figure Effective number Invalid number
Embodiment 1 group 100 95 95% 3 1 1
Embodiment 2 groups 100 96 96% 2 1 1
Embodiment 3 groups 100 100 100% 0 0 0
Matched group 100 42 42% 10 13 35
2 four groups of table is cured after treating 4 courses for the treatment of respectively, effective and effective time comparative example (%)
Group Number of cases 1st course for the treatment of 2nd course for the treatment of 3rd course for the treatment of 4th course for the treatment of
Embodiment 1 group 99 23(23.2%) 24(24.2%) 25(25.3%) 27(27.3%)
Embodiment 2 groups 99 23(23.2%) 24(24.2%) 25(25.3%) 27(27.3%)
Embodiment 3 groups 100 24(24%) 25(25%) 25(25%) 26 (26%)
Matched group 55 0(0%) 5(9.1%) 11(20%) 39(70.9%)
According to the clinical statistics in above table, the pharmaceutical composition that the present invention provides has that healing time is short, short treating period, Good effect, the features such as safety is high, with strong points.
Model case:
In December, 2015 Taian Shandong finds the pup at 15 3 monthly ages, finds wherein have 5 main retch occur, and rhinorrhea, with exhaling Suction flows outwardly more nose liquid, antiadoncus, anorexia, paroxysmal dyspnea, down in spirits, loss of appetite, muscular tremor, The symptoms such as breathing is urged, visual mucosa cyanosis, select a wherein sick pup to carry out Serological testing, are diagnosed as canine infectious Tracheitis.Immediately pup symptom do not occur is isolated raising place.Choose 5 ill pups therein, use the present invention The medicine 1 that embodiment is 1 group, dose be every every day 0.3g be uniformly blended in basal diet, feed 15 days, the 10th day ill children Dog symptom is obviously improved, and within the 15th day, 5 pups are all fully recovered, and cures after continuing to feed 5 days.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all spirit in the present invention and Within principle, any modification, equivalent substitution and improvement etc. made, should be included within the scope of the present invention.

Claims (8)

1. the pharmaceutical composition treating Infectious Tracheobroncheitis, it is characterised in that described pharmaceutical composition includes following Raw medicinal material: Radix ardisiae japonicae, Radix Cudraniae, flower, Herba Cichorii, Semen Ginkgo, Radix Inulae Nervosae, Herba Taraxaci, Rhizoma Begoniae Fimbristipulatae, Radix Linderae Glaucae, tingia bag I, Ganoderma, Herba Violae diamantiacae, Semen Oroxyli, the Radix Stemonae, Flos Lonicerae, Herb Gynostemmae Pentaphylli, Stachys palustris L., hair leaf Chinese photinia, Fructus Lycii, hilllock Eurya plant, three Mark, shamrock, Herba Scindapsi Officinalis, Herba Bulbophylli inconspicui, Herba youngiae japonicae and Radix ceratostigmatis willemottiani.
The pharmaceutical composition of Infectious Tracheobroncheitis the most according to claim 1, it is characterised in that each in described medicine The parts by weight of raw medicinal material are: Radix ardisiae japonicae 12-24 weight portion, Radix Cudraniae 10-30 weight portion, flower 14-26 weight portion, chrysanthemum Lettuce 15-35 weight portion, Semen Ginkgo 2-4 weight portion, Radix Inulae Nervosae 11-21 weight portion, Herba Taraxaci 13-23 weight portion, Rhizoma Begoniae Fimbristipulatae 14-28 weight Amount part, Radix Linderae Glaucae 15-35 weight portion, tingia Farfugium kaemferi 12-22 weight portion, Ganoderma 10-40 weight portion, Herba Violae diamantiacae 13-31 weight Part, Semen Oroxyli 14-28 weight portion, Radix Stemonae 3-5 weight portion, Flos Lonicerae 14-22 weight portion, Herb Gynostemmae Pentaphylli 15-35 weight portion, light leaf water Soviet Union's 12-24 weight portion, hair leaf Chinese photinia 7-14 weight portion, Fructus Lycii 9-18 weight portion, hilllock Eurya plant 15-25 weight portion, three mark 12-24 Weight portion, shamrock 14-32 weight portion, Herba Scindapsi Officinalis 11-21 weight portion, Herba Bulbophylli inconspicui 14-34 weight portion, Herba youngiae japonicae 10-20 weight Part and Radix ceratostigmatis willemottiani 15-35 weight portion.
The pharmaceutical composition of Infectious Tracheobroncheitis the most according to claim 1 and 2, it is characterised in that described medicine In the parts by weight of each raw medicinal material be: Radix ardisiae japonicae 14-22 weight portion, Radix Cudraniae 10-30 weight portion, flower 15-25 weight Part, Herba Cichorii 15-35 weight portion, Semen Ginkgo 2-3 weight portion, Radix Inulae Nervosae 12-20 weight portion, Herba Taraxaci 14-22 weight portion, Rhizoma Begoniae Fimbristipulatae 14-26 weight portion, Radix Linderae Glaucae 15-35 weight portion, tingia Farfugium kaemferi 12-20 weight portion, Ganoderma 10-40 weight portion, Herba Violae diamantiacae 13- 30 weight portions, Semen Oroxyli 14-28 weight portion, Radix Stemonae 3-4 weight portion, Flos Lonicerae 15-20 weight portion, Herb Gynostemmae Pentaphylli 15-35 weight portion, Stachys palustris L. 14-22 weight portion, hair leaf Chinese photinia 7-13 weight portion, Fructus Lycii 9-16 weight portion, hilllock Eurya plant 15-25 weight portion, three Mark 12-22 weight portion, shamrock 15-32 weight portion, Herba Scindapsi Officinalis 12-20 weight portion, Herba Bulbophylli inconspicui 15-32 weight portion, Herba youngiae japonicae 10- 20 weight portions and Radix ceratostigmatis willemottiani 15-35 weight portion.
4. according to the pharmaceutical composition of the Infectious Tracheobroncheitis described in any one of claim 1-3, it is characterised in that described In medicine, the parts by weight of each raw medicinal material are: Radix ardisiae japonicae 15-22 weight portion, Radix Cudraniae 10-30 weight portion, flower 15-23 Weight portion, Herba Cichorii 15-35 weight portion, Semen Ginkgo 2-3 weight portion, Radix Inulae Nervosae 12-20 weight portion, Herba Taraxaci 14-22 weight portion, red sky Certain herbaceous plants with big flowers 14-25 weight portion, Radix Linderae Glaucae 15-35 weight portion, tingia Farfugium kaemferi 12-20 weight portion, Ganoderma 10-40 weight portion, Herba Violae diamantiacae 15-30 weight portion, Semen Oroxyli 14-26 weight portion, Radix Stemonae 3-4 weight portion, Flos Lonicerae 16-20 weight portion, Herb Gynostemmae Pentaphylli 15-32 weight Part, Stachys palustris L. 14-20 weight portion, hair leaf Chinese photinia 8-12 weight portion, Fructus Lycii 9-15 weight portion, hilllock Eurya plant 15-25 weight portion, three Branch mark 12-21 weight portion, shamrock 18-32 weight portion, Herba Scindapsi Officinalis 12-20 weight portion, Herba Bulbophylli inconspicui 16-30 weight portion, Herba youngiae japonicae 10-20 weight portion and Radix ceratostigmatis willemottiani 15-33 weight portion.
5. according to the pharmaceutical composition of the Infectious Tracheobroncheitis described in any one of claim 1-4, it is characterised in that described In medicine, the parts by weight of each raw medicinal material are: Radix ardisiae japonicae 17 weight portion, Radix Cudraniae 20 weight portion, spend 22 weight portions, chrysanthemum Lettuce 32 weight portion, Semen Ginkgo 2 weight portion, Radix Inulae Nervosae 14 weight portion, Herba Taraxaci 19 weight portion, Rhizoma Begoniae Fimbristipulatae 22 weight portion, Radix Linderae Glaucae 32 weight portions, tingia Farfugium kaemferi 15 weight portion, Ganoderma 30 weight portion, Herba Violae diamantiacae 20 weight portion, Semen Oroxyli 15 weight portion, the Radix Stemonae 3 weight Amount part, Flos Lonicerae 17 weight portion, Herb Gynostemmae Pentaphylli 30 weight portion, Stachys palustris L. 16 weight portion, hair leaf Chinese photinia 12 weight portion, Fructus Lycii 14 Weight portion, hilllock Eurya plant 23 weight portion, three marks 12 weight portions, shamrock 30 weight portion, Herba Scindapsi Officinalis 15 weight portion, Herba Bulbophylli inconspicui 18 weight Part, Herba youngiae japonicae 10 weight portion and Radix ceratostigmatis willemottiani 32 weight portion.
6. according to the pharmaceutical composition of the Infectious Tracheobroncheitis described in any one of claim 1-5, it is characterised in that described In medicine, the parts by weight of each raw medicinal material are: Radix ardisiae japonicae 21 weight portion, Radix Cudraniae 19 weight portion, spend 22 weight portions, chrysanthemum Lettuce 32 weight portion, Semen Ginkgo 2 weight portion, Radix Inulae Nervosae 16 weight portion, Herba Taraxaci 20 weight portion, Rhizoma Begoniae Fimbristipulatae 16 weight portion, Radix Linderae Glaucae 32 weight portions, tingia Farfugium kaemferi 18 weight portion, Ganoderma 30 weight portion, Herba Violae diamantiacae 25 weight portion, Semen Oroxyli 22 weight portion, the Radix Stemonae 3 weight Amount part, Flos Lonicerae 17 weight portion, Herb Gynostemmae Pentaphylli 28 weight portion, Stachys palustris L. 15 weight portion, hair leaf Chinese photinia 10 weight portion, Fructus Lycii 13 Weight portion, hilllock Eurya plant 24 weight portion, three marks 15 weight portions, shamrock 30 weight portion, Herba Scindapsi Officinalis 16 weight portion, Herba Bulbophylli inconspicui 24 weight Part, Herba youngiae japonicae 15 weight portion and Radix ceratostigmatis willemottiani 32 weight portion.
7. according to the pharmaceutical composition of the Infectious Tracheobroncheitis described in any one of claim 1-6, it is characterised in that described In medicine, the parts by weight of each raw medicinal material are: Radix ardisiae japonicae 20 weight portion, Radix Cudraniae 30 weight portion, spend 21 weight portions, chrysanthemum Lettuce 19 weight portion, Semen Ginkgo 3 weight portion, Radix Inulae Nervosae 16 weight portion, Herba Taraxaci 21 weight portion, Rhizoma Begoniae Fimbristipulatae 23 weight portion, Radix Linderae Glaucae 32 weight portions, tingia Farfugium kaemferi 16 weight portion, Ganoderma 35 weight portion, Herba Violae diamantiacae 25 weight portion, Semen Oroxyli 22 weight portion, the Radix Stemonae 4 weight Amount part, Flos Lonicerae 18 weight portion, Herb Gynostemmae Pentaphylli 30 weight portion, Stachys palustris L. 16 weight portion, hair leaf Chinese photinia 10 weight portion, Fructus Lycii 13 Weight portion, hilllock Eurya plant 22 weight portion, three marks 14 weight portions, shamrock 30 weight portion, Herba Scindapsi Officinalis 15 weight portion, Herba Bulbophylli inconspicui 20 weight Part, Herba youngiae japonicae 15 weight portion and Radix ceratostigmatis willemottiani 32 weight portion.
8., according to the preparation method of the pharmaceutical composition of the Infectious Tracheobroncheitis described in any one of claim 1-7, it is special Levying and be, described preparation method comprises the following steps: is all put in pulverizer by described raw medicinal material and is ground into fine powder, puts into Acid and alkali-resistance infusion kettle, pours into the ethanol that determining alcohol is 80%-90% relative to 3-5 times of fine powder quality in pot, normal at room temperature Pressure, impregnates 20-30 days, the liquid impregnated and dregs pressing is filtered subsequently, and filtrate reduced in volume obtains paste, puts into baking Case is dried, and the temperature of oven drying is 110-115 DEG C, 10-20 minute drying time, grinds to form 150-250 mesh fine powder after drying, Make that its fine powder amount reaches always to expect more than 95%, obtains described medicine.
CN201610384917.5A 2016-06-02 2016-06-02 Pharmaceutical composition for treating canine infectious bronchitis and preparation method thereof Withdrawn CN105998970A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107495340A (en) * 2017-08-11 2017-12-22 安徽中森生物技术有限公司 A kind of anti-trioxypurine diuretic compositions and preparation method thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104001045A (en) * 2014-05-13 2014-08-27 山东新希望六和集团有限公司 Drug for treating dog pneumonia and preparation method thereof
CN104706766A (en) * 2013-12-11 2015-06-17 天津嘉创生物科技有限公司 Oral liquid with heat clearing, toxicity removing, and cough and asthma relieving functions and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104706766A (en) * 2013-12-11 2015-06-17 天津嘉创生物科技有限公司 Oral liquid with heat clearing, toxicity removing, and cough and asthma relieving functions and preparation method thereof
CN104001045A (en) * 2014-05-13 2014-08-27 山东新希望六和集团有限公司 Drug for treating dog pneumonia and preparation method thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107495340A (en) * 2017-08-11 2017-12-22 安徽中森生物技术有限公司 A kind of anti-trioxypurine diuretic compositions and preparation method thereof

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