CN104784491A - Traditional Chinese medicine preparation for treating salpingitis of laying hens and preparation method thereof - Google Patents

Abstract

The invention provides a traditional Chinese medicine preparation for treating salpingitis of laying hens and a preparation method thereof. The traditional Chinese medicine preparation comprises the following raw material medicines: root of toothed habenaria, common fibraurea stem, rhizome of large leaf Japanese ginseng, fructificatio corioli, common nepenthes, root of smalleaf desmodium, leaf of puberulous glochidion, common aeschynomene herb, root of evans begonia, Chinese sage herb, all-grass of irisleaf oberonia, digua fig stem, root of delavay ampelopsis, leaf and twig of fruticose breynia, carolina cranesbill herb, hypericum patulum and mountain pepper root. The traditional Chinese medicine preparation for treating the salpingitis of the laying hens and the preparation method thereof have the beneficial effects that the traditional Chinese medicine preparation for treating the salpingitis of the laying hens has the advantages of exact curative effect, no toxic and side effects and no medicine residues; and the egg laying rate of the laying hens can be improved, and the habitus and the disease resistance of the laying hens can be reinforced.

Description

A kind of Chinese medicine preparation for the treatment of hens salpingitis and preparation method thereof

Technical field

The present invention relates to the cultivated animals feed additive containing deriving from plant, animal or mineral component, particularly relating to a kind of Chinese medicine preparation for the treatment of hens salpingitis and preparation method thereof.

Background technology

Hens salpingitis is a kind of common disease of laying hen, and its clinical manifestation is varied, but all to cause laying hen laying rate to decline, shell egg, soft-shelled egg, arenaceous shell egg, abnormal-shape egg, white shell egg, small-sized egg increase as cardinal symptom.

The infection of hens salpingitis because of the feeding and management level of raiser, environmental health, prophylactico-therapeutic measures difference and have significant difference, with or without the impact of the factors such as other epidemic disease of secondary, thus cause the M & M of Chicken salpingitis also to have larger difference.Its cause of disease is more complicated, is one of frequently-occurring disease threatening aquaculture, has carried out great impact also to cultivation industrial belt simultaneously.

Pathogenic factor: the reason that primary disease occurs is more, as pouity dwelling place sanitary condition is too poor, cloaca is polluted by antibacterial (as Salmonella pullorum, Salmonella paratyphi, escherichia coli etc.) and invades fallopian tube; Or feeding animals feedstuff is too much, lay eggs excessive or produce double-yolked egg, eggshell breaks in fallopian tube sometimes, damage fallopian tube; Or lay eggs too much, be deficient in vitamin in feedstuff A, D, E etc. all can cause salpingitis.Poultry suffers from salpingitis, often causes prolapse of fallopian tube, difficult labour etc.High yield hen raw then easily sends out primary disease.

Cardinal symptom: chicken group outward appearance is normal, but without egg-laying peak.The salpingitic sick fowl main manifestations of infected chicken is that pain is uneasy, and difficulty of laying eggs has pain, often with bloodstain on its eggshell of the egg of output.Often discharge Huang, white pus sample secretions in fallopian tube, pollute perianal and feather below thereof.Along with the development of the state of an illness, pain is uneasy, and body temperature raises, sometimes in lethargy shape, normal sleeping ground does not rise, and abdominal part of walking lands, the salpingitic sick fowl of infected chicken starts heating, and after heat is moved back, stand transfixed to the ground, two wings are sagging, feather pine disorderly, some abdominal paries, by ground or lethargy, can cause peritonitis, or salpingorrhexis cause yolk peritonitis when inflammation spreads to abdominal cavity.

Summary of the invention

Technical problem to be solved by this invention is, provides a kind of determined curative effect, has no side effect and the Chinese medicine preparation and preparation method thereof for the treatment of hens salpingitis of drug residue free.

In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine preparation for the treatment of hens salpingitis, each raw medicinal material of described Chinese medicine preparation comprises: Radix Habenariae Dentatae, Caulis Fibraureae, Rhizoma Panacis Majoris, Coriolous Dersicolor (Fr.) Quel, Herba nepenthis, Folium glochidionis puberi, Radix desmodiik microphylli, Herba Aeschynonenes Indicae, Radix Bischofiae Javanicae, Herba Salviae Chinensis, Herba Oberoniae iridifoliae, Caulis et Folium fici Tikouae, Radix Ampelopsis delavayanae, Folium et cacumen Breyniae Fruticosae, Herba Erodii, Herba Hyperici Patuli and Radix Linderae Glaucae.

Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine preparation can be preferably as follows: Radix Habenariae Dentatae 30 ~ 40 parts, Caulis Fibraureae 40 ~ 50 parts, Rhizoma Panacis Majoris 20 ~ 30 parts, Coriolous Dersicolor (Fr.) Quel 10 ~ 20 parts, Herba nepenthis 10 ~ 20 parts, Folium glochidionis puberi 5 ~ 15 parts, Radix desmodiik microphylli 15 ~ 25 parts, Herba Aeschynonenes Indicae 10 ~ 20 parts, Radix Bischofiae Javanicae 20 ~ 30 parts, Herba Salviae Chinensis 30 ~ 40 parts, Herba Oberoniae iridifoliae 10 ~ 20 parts, Caulis et Folium fici Tikouae 20 ~ 30 parts, Radix Ampelopsis delavayanae 5 ~ 15 parts, Folium et cacumen Breyniae Fruticosae 5 ~ 15 parts, Herba Erodii 15 ~ 25 parts, Herba Hyperici Patuli 20 ~ 30 parts and Radix Linderae Glaucae 10 ~ 20 parts.

Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine preparation can be preferably as follows: Radix Habenariae Dentatae 35 ~ 40 parts, Caulis Fibraureae 45 ~ 50 parts, Rhizoma Panacis Majoris 25 ~ 30 parts, Coriolous Dersicolor (Fr.) Quel 15 ~ 20 parts, Herba nepenthis 10 ~ 15 parts, Folium glochidionis puberi 5 ~ 10 parts, Radix desmodiik microphylli 20 ~ 25 parts, Herba Aeschynonenes Indicae 10 ~ 15 parts, Radix Bischofiae Javanicae 25 ~ 30 parts, Herba Salviae Chinensis 30 ~ 35 parts, Herba Oberoniae iridifoliae 15 ~ 20 parts, Caulis et Folium fici Tikouae 20 ~ 25 parts, Radix Ampelopsis delavayanae 10 ~ 15 parts, Folium et cacumen Breyniae Fruticosae 5 ~ 10 parts, Herba Erodii 15 ~ 20 parts, Herba Hyperici Patuli 25 ~ 30 parts and Radix Linderae Glaucae 10 ~ 15 parts.

Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine preparation can be preferably as follows: Radix Habenariae Dentatae 36 parts, Caulis Fibraureae 50 parts, Rhizoma Panacis Majoris 27 parts, Coriolous Dersicolor (Fr.) Quel 18 parts, Herba nepenthis 12 parts, Folium glochidionis puberi 8 parts, Radix desmodiik microphylli 24 parts, Herba Aeschynonenes Indicae 11 parts, Radix Bischofiae Javanicae 27 parts, Herba Salviae Chinensis 34 parts, Herba Oberoniae iridifoliae 15 parts, Caulis et Folium fici Tikouae 23 parts, Radix Ampelopsis delavayanae 14 parts, Folium et cacumen Breyniae Fruticosae 6 parts, Herba Erodii 17 parts, Herba Hyperici Patuli 28 parts and Radix Linderae Glaucae 13 parts.

Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine preparation can be preferably as follows: Radix Habenariae Dentatae 39 parts, Caulis Fibraureae 47 parts, Rhizoma Panacis Majoris 28 parts, Coriolous Dersicolor (Fr.) Quel 16 parts, Herba nepenthis 15 parts, Folium glochidionis puberi 5 parts, Radix desmodiik microphylli 22 parts, Herba Aeschynonenes Indicae 13 parts, Radix Bischofiae Javanicae 29 parts, Herba Salviae Chinensis 32 parts, Herba Oberoniae iridifoliae 19 parts, Caulis et Folium fici Tikouae 25 parts, Radix Ampelopsis delavayanae 11 parts, Folium et cacumen Breyniae Fruticosae 9 parts, Herba Erodii 18 parts, Herba Hyperici Patuli 26 parts and Radix Linderae Glaucae 14 parts.

Wherein, when the dosage form of described Chinese medicine preparation is powder, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine preparation raw medicinal material, and adding relative to the determining alcohol of mixture quality 5 ~ 7 times is the ethanol of 65 ~ 75%, reflux 2 ~ 4 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 ~ 4 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds the starch relative to its quality 2 ~ 4 times in the micropowders obtained by second step, mixing, obtains powder.

Wherein, when the dosage form of described Chinese medicine preparation is oral solutions, its preparation method comprises the following steps:

The first step, Radix Habenariae Dentatae, Caulis Fibraureae, Rhizoma Panacis Majoris, Coriolous Dersicolor (Fr.) Quel, Herba nepenthis, Folium glochidionis puberi, Radix desmodiik microphylli, Herba Aeschynonenes Indicae and Radix Bischofiae Javanicae are mixed in proportion, be that the methanol of 70% ~ 80% is as solvent with determining alcohol, adopt percolation with the speed of 1 ~ 3ml per minute slowly percolation, collect percolate, concentrating under reduced pressure is also dry, obtains and gets dry extract, be ground into 200 ~ 300 object powder, the quality of the methanol added is 3 ~ 5 times of first step mixture quality;

Second step, is mixed in proportion surplus stock medical material, is ground into 100 ~ 200 object powder;

3rd step, in the powder that second step obtains, adds the distilled water of the powder quality 3 ~ 6 times obtained relative to second step, decocts 2 ~ 4 hours, filter, obtain the first filtrate; Filtering residue is added the distilled water relative to its quality 2 ~ 4 times, decoct 1 ~ 2 hour, filter, obtain the second filtrate; Merge the first filtrate and the second filtrate, concentrate away the water of 2/3 ~ 3/4 volume, add the ethanol that determining alcohol is 90 ~ 95%, make determining alcohol reach 70% ~ 80%, leave standstill 12 ~ 24 hours, filter, concentrating under reduced pressure, drying, obtains and gets dry extract, and is ground into 200 ~ 300 object powder;

4th step, the powder mixing first step and the 3rd step obtained, add the distilled water relative to mixed-powder quality 3 ~ 5 times amount, the sucrose of 0.1 ~ 0.3 times, the sodium benzoate of 0.01 ~ 0.02 times, stir, boil, cooling, filter, subpackage, namely sterilizing obtains oral liquid.

Beneficial effect of the present invention: Chinese medicine preparation of the present invention has determined curative effect to treatment hens salpingitis, not easily recur, has no side effect, the advantage of drug residue free, and can improve the laying rate of laying hen, good egg rate, the body constitution strengthening laying hen and resistance against diseases.

Detailed description of the invention

The invention provides a kind of Chinese medicine preparation for the treatment of hens salpingitis, each raw medicinal material of Chinese medicine preparation comprises: Radix Habenariae Dentatae, Caulis Fibraureae, Rhizoma Panacis Majoris, Coriolous Dersicolor (Fr.) Quel, Herba nepenthis, Folium glochidionis puberi, Radix desmodiik microphylli, Herba Aeschynonenes Indicae, Radix Bischofiae Javanicae, Herba Salviae Chinensis, Herba Oberoniae iridifoliae, Caulis et Folium fici Tikouae, Radix Ampelopsis delavayanae, Folium et cacumen Breyniae Fruticosae, Herba Erodii, Herba Hyperici Patuli and Radix Linderae Glaucae.

In described Chinese medicine, the pharmacology of each raw medicinal material is as follows:

Radix Habenariae Dentatae: [another name] swan hatches, beautiful phoenix spends root, Radix Satyrii nepalensis, two Sphallerocarpus gracilis, twoflower rattlesnake plantain, old hen is hatched, golden goose hatches, Ren caprae seu ovis ginseng, Buddha's warrior attendant are complied with one's wishes, to Radix Ginseng, swelling and hanging down of either of the testes medicine, ovum gallinaceum ginseng, mountain Dens Elephatis, kidney seven.[source] medical material Ji Yuan: be the tuber of the beautiful phoenix flower of orchid Pluma Anseris domestica.[nature and flavor] are sweet; Bitter; Flat.[return through] lung; Kidney channel.[function cures mainly] the kidney invigorating lung benefiting; Dampness removing; Removing toxic substances.Main lumbago due to renal deficiency; Sexual impotence; Pulmonary tuberculosis cough; Edema; Leukorrhagia; Hernia; Carbuncle furunculosis; Snake bite and insect sting.[each discussion] 1. " Jiangxi medical herbs ": loose gas, removing toxic substances.2. " Kunming conventional medical herbs among the people ": nourishing lung and kidney, diuresis, antiinflammatory.3. " choosing of Simao, Yunnan Chinese herbal medicine ": nourishing, relieving cough and resolving phlegm.Control orchitis, salpingitis, the cough of body void.[extracts] " China's book on Chinese herbal medicine "

Caulis Fibraureae: [another name] Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori), Rhizoma Coptidis rattan, Caulis Tinosporae, mountain king, huangteng, Herba Aristolochiae, JINSUOSHI.[source] medical material Ji Yuan: be rhizome or the leaf of menispermaceous plants Caulis Fibraureae.[nature and flavor] are bitter; Cold in nature.[return through] heart; Liver Channel.[function cures mainly] heat-clearing and toxic substances removing; Dampness removing.Main acute tonsillitis, pharyngolaryngitis, upper respiratory tract infection; Conjunctivitis; Jaundice; Gastroenteritis; Dysentery; Infantile dyspepsia; Food poisoning; Salpingitis; Acute and chronic endometritis; Acute pelvic inflammatory disease; Vaginitis; Furuncle; Burn and scald.[extracts] " China's book on Chinese herbal medicine "

Rhizoma Panacis Majoris: [source] this product is the dry rhizome of Araliaceae Rhizoma Panacis Majoris Panax japonicus C.A.Mey.var.major (Burk.) C.Y.Wu et K.M.Feng or Rhizoma Panacis bipinnatifidi (bamboo root Radix Notoginseng, turn round son seven, Rhizoma Coptidis Radix Notoginseng, floral leaf Radix Notoginseng) Panax japonicusC.A.Mey.var.bipinnatifidus (seem.) C.Y.Wu et K.M.Feng.Autumn excavates, removing rough bark and fibrous root, dry; Or steam (boiling) rear drying thoroughly.[nature and flavor] are bitter, sweet, are slightly cold.[return through] returns liver, lung, stomach warp.[function cures mainly] tonifying the lung, yin nourishing, active, hemostasis.For deficiency of both QI and YIN, dysphoria with smothery sensation is thirsty, cough due to consumptive disease, injury from falling down, arthralgia, hemoptysis, spits blood, traumatic hemorrhage.[extracts] " Chinese Pharmacopoeia "

Coriolous Dersicolor (Fr.) Quel: [another name] Coriolus Versicolor, yellow Coriolous Dersicolor (Fr.) Quel, grey sesame, watt bacterium, bright cloud leather lid bacterium, polychrome bolete, redly see hands, thousand layers of mushroom, lathe work Coriolous Dersicolor (Fr.) Quel.[source] medical material Ji Yuan: be the sporophore of On Polyporaceae Corilus versicolor Quel..Latin plant animal mineral name: Coriolus versicolor (L.exFr.) Quel. [Polystictus versicolor (L.) Fr.].Gather and store: the whole year all can gather, removing impurity, dries.[nature and flavor] are sweet; Light; Be slightly cold.[return through] liver; Spleen; Lung meridian.[function cures mainly] invigorating spleen to remove dampness; Relieving cough and asthma; Heat-clearing and toxic substances removing; Antitumor.Main chronic active hepatitis; Hepatitis interstitialis chronica; Chronic bronchitis; Infantile spasm bronchitis; Laryngopharynx swelling and pain; Kinds of tumors; Rheumatoid arthritis; Leukemia.[extracts] " China's book on Chinese herbal medicine "

Herba nepenthis: [another name] catchfly, the monkey field of razor clam, zhuzailong, danshuitong, monkey cage, gongzaiping.[source] medical material Ji Yuan: be the stem and leaf of Nepenthaceae plant Herba nepenthis.Latin plant animal mineral name: Nepenthes mirabilis (Lour.) Druce.Gather and store: autumn gathers, cutting is dried.[nature and flavor] are sweet; Light; Cool.[return through] lung; Gallbladder; Stomach warp.[function cures mainly] nourishing the lung to arrest cough; Clearing away heat-damp and promoting diuresis calculus; Removing toxic substances and promoting subsidence of swelling.Main dryness of the lung hemoptysis; Cold cough; Pertussis; Jaundice; Dysentery; Lithangiuria; Also can be used for gastric and duodenal ulcers; Hypertension; Diabetes; Skin infection carbuncle.[each discussion] be " Luchuan book on Chinese herbal medicine " 1.: antiinflammatory, removing toxic substances, and row water, harnesses the river swollen, dysentery, carbuncle sore, and ulcer is red and swollen, and insect bite is hindered, and controls traumatic injury.2. " Guangdong Chinese medicine " II: lung heat clearing portion dryness-fire, controls hemoptysis.3. Guangzhou army " conventional Chinese herbal medicine handbook ": clearing away heat-damp and promoting diuresis, preventing phlegm from forming and stopping coughing.Control icterohepatitis, gastric and duodenal ulcers pain, lithangiuria, hypertension, cold cough, pertussis.[extracts] " China's book on Chinese herbal medicine "

Folium glochidionis puberi: [source] is come from " Jiangxi traditional herbal medicine ".[another name] calabazilla leaf.[source] medical material Ji Yuan: be the leaf of euphorbia plant Fructus glochidionis puberi(Herba Glochidii Puberi) Glochidion puberum (L.) Hutch..Latin plant animal mineral name: Glochidion puberum (L.) Huteh. [Agy neia pubera L.].Gather and store: summer, autumn gather, using fresh herb or dry for subsequent use.[nature and flavor] bitter in the mouth; Puckery; Cool in nature; Mild toxicity.[return through] large intestine channel.[function cures mainly] clearing away heat-damp and promoting diuresis; Removing toxic substances and promoting subsidence of swelling.Main damp-heat dysentery; Jaundice; Stranguria with turbid discharge; Leukorrhagia; Heating; Throat kind pain; Carbuncle furuncle swells; Dermatitis rhus; Eczema; Worm venom.[each discussion] 1. " Guangxi Chinese medicinal herbal ": dampness removing, removing blood stasis, separate dermatitis rhus, snake venom.Control dermatitis rhus, dysentery, traumatic injury, Serpentis stings poison.2. " Guangdong Chinese medicine " II: disappear stagnant, removing dampness, heat clearing away, relaxing muscles and tendons and activating QI and blood in the collateral.Control dysentery, flu, influenza, excessive physical fatigue, Mus, venom.[extracts] " China's book on Chinese herbal medicine "

Radix desmodiik microphylli: [source] is come from " Yunnan Chinese herbal medicine ".It is fragrant that [another name] climbs ground; Herba desmodii microphylli root.[source] medical material Ji Yuan: be the root of leguminous plant Herba Desmodii Microphylli Desmodium microphylLum (Thunb.) DC..Latin plant animal mineral name: Desmodium microphyllum (Thunb.) DC. [Hedysarum microphyllum Thunb.].Gather and store: summer, autumn gather, using fresh herb or dry.[nature and flavor] are sweet; Bitter; Cool.[return through] liver; Bladder; Large intestine channel.[function cures mainly] clearing away heat-damp and promoting diuresis; Relieving cough and asthma; Subduing swelling and detoxicating.Main stranguria caused by urinary stone; Stomachache; Jaundice; Dysentery; Cough; Asthma; Infantile malnutrition; Venom; Carbuncle skin ulcer scrofula; Dermatitis rhus; Hemorrhoid.[each discussion] 1. " Yunnan Chinese herbal medicine ": anti-inflammation hemostasia, dampness removing dredging collateral.Control puerperal hemorrhage, redly collapse leucorrhea, amenorrhea, weak night sweat, dysentery, rheumatism, urinary tract infection, hemorrhoid, proctoptosis, traumatic injury.2. Jiangxi " medical herbs handbook ": clearing away heat to improve acuity of vision.[extracts] " China's book on Chinese herbal medicine "

Herba Aeschynonenes Indicae: [source] is come from " will planted by middle traditional Chinese medicines ".[English name] Common AeschynomeneHerb, Herb of Common Aeschynomene.[another name] water antler, close bright grass, Herba Cassiae Nomamis, raft bean, wooden barnyard grass, only wooden root, wild Fructus Gleditsia, comb tree, wild Herba Mimosae Pudicae, Scolopendra willow, wild Sophora japonica L., Herba Lespedezae Cuneatae, standing grain sickle grass, Radix Rhapontici, wild duck tree grass, wild cold bean, wild beanstalk, Hai Liu, draw field grass.[source] medical material Ji Yuan: be the aerial parts of leguminous plant Herba Aeschynonenes Indicae.Latin plant animal mineral name: Aeschynomene indica L.Gather and store: the 9-10 month gathers, and extracts aerial parts together, using fresh herb or dry.[nature and flavor] sweetness and bitterness; Cold; Nontoxic.[return through] lung; Stomach warp.[function cures mainly] clearing away heat-damp and promoting diuresis, dispelling pathogenic wind for improving eyesight, lactogenesis.Main pyretic stranguria, stranguria with blood, edema, has loose bowels, furuncle and phyma, skin ulcer scabies, conjunctival congestion and swelling pain, and look unfamiliar nebula, nyctalopia, arthralgia, and puerpera's breast is few.[each discussion] 1. supplement to the Herbal: main sudden high fever is drenched, hot urination, and children's's clonic convulsion is sick.Improving eyesight, lower water, hemostasis dysentery.Smash strand juice clothes.2. " Zhiwu Mingshi Tukao ": remove wind, parasite killing.3. " Tian Bao book on Chinese herbal medicine ": pathogenic wind expelling, de-swelling.Treat Scarabaeiform infantile malnutrition, jaundice, edema of the dorsum of the foot poison.4. " classify herbal ": control fire swollen.Steamed chicken, relieving stranguria by diuresis.5. Guangzhou army " conventional Chinese herbal medicine handbook ": heat clearing away disappears stagnant.Control flatulence, dyspepsia, ache induced by gastritis, anemopyretic cold, eczema, dermatitis.6. " Jiangxi medical herbs ": clearing away heat-damp and promoting diuresis, detumescence hemostasis.[extracts] " China's book on Chinese herbal medicine "

Radix Bischofiae Javanicae: [source] is come from " Guizhou side's medicine among the people collection ".[another name] YIKOUXUE, gold thread hoist, red white two balls, Radix Bischofiae Javanicae.[source] medical material Ji Yuan: be the root of Begoniaceae plant Flos Begoniae Evansianae.Latin plant animal mineral name: Begonia evansiana Andr. gathers and stores: the whole year all can gather; Uproot; Clean; Using fresh herb; Or section is dried.[nature and flavor] sour in the mouth; Puckery.[function cures mainly] blood stasis dispelling; Hemostasis; Clearing away heat-damp and promoting diuresis.Main traumatic injury; Spit blood, spit blood; Epistaxis; Knife injury is hemorrhage; Metrorrhagia; Blood stasis amenorrhea; Menoxenia; Leukorrhagia; Stranguria with turbid discharge; Dysentery; Stomachache; Laryngopharynx swelling and pain.[each discussion] 1 " classifying herbal ": control haematemesis, traumatic injury.2. " Guizhou side among the people medicine collection ": emesis blood, spitting of blood, knife injury are hemorrhage.3. " Shaanxi Chinese herbal medicine ": promoting blood circulation to remove blood stasis, heat clearing away, hemostasis and pain-relieving.Control traumatic injury, spit blood, epistaxis, gastric ulcer, dysentery, lung abscess, metrorrhagia, leucorrhea, menoxenia.4. " Guizhou medical herbs ": blood circulation promoting and blood stasis dispelling, cooling blood for hemostasis.5. Jiangxi " medical herbs handbook ": circulation of qi promoting promoting the circulation of blood, reducing swelling and alleviating pain, spasmolytic, controls scrofula.[extracts] " China's book on Chinese herbal medicine "

Herba Salviae Chinensis: [source] is come from " detailed outline ".[another name] Herba Salviae Chinensis, five phoenixes flower, little Radix Salviae Miltiorrhizae, below the moon red, black sand-grass, black face wind, Rsdix Wisterinae Venustae, Herba Salviae Chinensis, stone great river, mountain seam take, Zi Danhua, Arisaema balansae Engl. ginseng, Herba Scutellariae Barbatae, field Herba Apii graveolentis, HUOXUECAO.[source] medical material Ji Yuan: be the herb of labiate Salvia chinensis.Latin plant animal mineral name: Salvia chinensis Benth.Gather and store: florescence taps herb, using fresh herb or dry.[nature and flavor] acrid in the mouth; Bitter; Cold nature.[return through] returns liver; Spleen channel.[function cures mainly] blood circulation promoting and blood stasis dispelling; Clearing away heat-damp and promoting diuresis; Mass dissipating and swelling eliminating.Main menoxenia; Dysmenorrhea; Amenorrhea; Metrorrhagia, has blood in stool; Jaundice due to damp-heat; Hot toxic-heat and blood stasis; Drench pain; Leukorrhagia; Rheumatic ostalgia; Scrofula; Skin ulcer swells; Acute mastitis; Herpes zoster; Leprosy; Traumatic injury wound is swollen.[extracts] " China's book on Chinese herbal medicine "

Herba Oberoniae iridifoliae: [source] is come from " choosing of Simao, Yunnan Chinese herbal medicine ".[another name] dovetail Rhizoma Tupistrae Wattii, fish tail bar grass, tree bamboo, rat tail, the flat orchid of stone, wild flat bamboo, the flat bamboo of stone, hair Mus tail.[source] medical material Ji Yuan: be the herb of orchid Rhizoma Iridis Tectori orchid.Latin plant animal mineral name: Oberonia iridifolia (Roxb.) Lindl. [Cymbidium iridifolium Roxb.].Gather and store: the whole year all can gather, boiled water dries after scalding.[nature and flavor] micro-hardship; Cool in nature.[return through] urinary bladder channel.[function cures mainly] clearing away heat-damp and promoting diuresis; Promoting blood circulation to remove obstruction in the collateral.Main urinary tract infection; Bronchitis; Asthma; Intestinal is scorching; Dyspepsia; Traumatic injury; Fracture.[extracts] " China's book on Chinese herbal medicine "

Caulis et Folium fici Tikouae: [source] is published in " Guizhou side's medicine among the people collection ".[another name] Caulis Entadae, Ipomoea hungaiensis Lingelsh. Et Borza., DIWUGONG, Cortex Ampelopsis Aconitifoliae Radicis, Radix Seu Caulis Mucunae Sempervirentis, cross SHILONG, Rhizoma et radix panici repentis, Radix Pachyrhizi Erosi stem, cattle holder nose, Radix Clematidis Clarkeanae, Nostoc commune, wild country melon vine, white slope tiger, climb ground milk, bore Pheretima, Herba hyperici elodeoidis, Caulis et Folium fici Tikouae, Folium Eriobotryae, within 10000 years, take off.[source] medical material Ji Yuan: be stem, the leaf of moraceae plants Radix Pachyrhizi Erosi banyan.Latin plant animal mineral name: Ficus tikoua Bur. gathers and stores: the 9-10 month gathers, cleans and dries.[nature and flavor] bitter in the mouth; Cold in nature.[function cures mainly] clearing away heat-damp and promoting diuresis; Promoting blood circulation to remove obstruction in the collateral; Removing toxic substances and promoting subsidence of swelling.Main cough due to lung-heat; Dysentery; Edema; Yellow cellulitis; Infantile dyspepsia; Rheumatalgia; Amenorrhea; Leukorrhagia; Traumatic injury; Bleeding hemorrhoids; Innominate toxic swelling.[extracts] " China's book on Chinese herbal medicine "

Radix Ampelopsis delavayanae: [source] is come from " Yunnan Chinese herbal medicine ".[another name] Ramulus et Folium Bischofiae Javanicae is logical, wild Jambul root, five pawl gold, Radix vitis romanetii, Delavay ampelopsis root, Hypoestes poilanei R. Benoistr., Herba Ipomoeae Cairicae, tetrastigma hemsleyanum, red Caulis et Folium cayratiae trifoliae, Radix seu folium Gaultheriae intermediae, fly Caulis Zanthoxyli multijugi, JIANZHONGXIAO, red red Pueraria lobota, red internal diabetes, red Pueraria lobota, black Caulis seu Radix Schisandrae Henryi, SANYE rattan, red Canis familiaris L. poplar.[source] medical material Ji Yuan: be root or the ratan of vitaceae trilobated leaf Caulis seu folium ampelopsis brevipedunculatae (Caulis Ampelopsis Brevipedunculae).Latin plant animal mineral name: Ampelopsis delavayana (Franch.) Planch. [Vitis delavayana Franch.] gathers and stores: ratan of gathering in summer, autumn, autumn excavates root, clean, cut into slices respectively, dry or dry.[nature and flavor] are pungent; Light; Puckery; Flat.[return through] heart; Liver Channel.[function cures mainly] clearing away heat-damp and promoting diuresis; Promoting blood circulation to remove obstruction in the collateral; Hemostasia and promoting granulation; Removing toxic substances and promoting subsidence of swelling.Main stranguria; Nebulousurine; Hernia; The swelling and hanging down of either of the testes; Rheumatic arthralgia; Traumatic injury congestive edema; Wound hemorrhage; Scald; Carbuncle sore.[each discussion] 1. " Shaanxi Chinese herbal medicine ": subduing swelling and detoxicating, hemostasis and pain-relieving, evacuation of pus granulation promoting, wind-damp dispelling.Control traumatic injury, fracture, rheumatic arthritis, rheumatic lumbago and scelalgia, has blood in stool, metrorrhagia, leucorrhea.2. " pharmacy circular ": control burn due to hot liquid or fire, wound, vomiting and diarrhoea, chronic ulcer and the skin damage caused by blister gases.(1960，8(2)：63)。3. " Yunnan proved recipe of traditional Chinese medicine ": hemostasis, pain relieving, anticorrosion, antiinflammatory, granulation promoting of drawing out the pus.Control bone to break broken skin, skin ulcer rash pain, burn due to hot liquid or fire.4. " Chinese herbal medicine is commonly used in Sichuan ": control traumatic injury, gold wound, knife injury, carbuncle malignant boil toxic swelling, pathogenic wind toxic trip is red.[extracts] " China's book on Chinese herbal medicine "

Folium et cacumen Breyniae Fruticosae: [source] is come from " Guangzhou air force commonly uses Chinese herbal medicine handbook ".[another name] Tanaka road, four eyed leaf, night blue tea, xylotrupes, crow is write, mausoleum male earner, Testis et penis Gallus domesticus leaf, pot cover are young, crow paint mortar, blue or green paint, mountain village orchid, Radix Polygalae Wattersii, paint SHENGCAO, monkey are write, wild Radix Betae.[source] medical material Ji Yuan: be the browse of euphorbia plant Folium et cacumen Breyniae Fruticosae.Latin plant animal mineral name: Breynia fruticosa (L.) Hook.f. [Andrachne fruticosa L.].Gather and store: the whole year all can gather, drying or using fresh herb.[nature and flavor] mildly bitter flavor; Cool in nature; Poisonous.[return through] large intestine; Liver Channel.[function cures mainly] clearing heat and expelling damp; Promoting blood circulation and detoxication.Main stomachache is vomited and diarrhoea; Eczema; Herpes zoster; Dermatitis; Dermatitis rhus; Rheumatic arthralgia; Puerperal galactostasis; Pudendal pruritus.[extracts] " China's book on Chinese herbal medicine "

Herba Erodii: [source] comes from supplementary Amplifications of the Compendium of Materia Medica.[another name] Herba Erodii, old official grass, five-petaled flowers, always pass through grass, Big Dipper grass, five leaf connection, Hydrocotyle sibthorpioides lam.Var.Batvachium (Hand.-Mazz.) et shan., crow muscle, pass through muscle, five tooth cakes, crow mouth, quail mouth.[source] medical material Ji Yuan: be the herb of MangNiu Er Seedling section plant Mang cattle Seedling, Herba Erodii, Siberia Herba Erodii, nepal cranesbill, tuber Herba Erodii band fruit.Gather and store: when summer, autumn, fruit was by maturation, extract aerial parts or Herb is pulled up, removing earth and impurity, dry.[nature and flavor] bitter in the mouth; Micro-pungent; Property is put down.[return through] spleen; Urinary bladder channel.[function cures mainly] dispelling wind and removing obstruction in the collateral; Invigorate blood circulation; Clearing away heat-damp and promoting diuresis.Main air pain of dampness syndrome; Numbness of the skin; Muscles and bones is miserable; Traumatic injury; Dysentery; Sore.[each discussion] be " the southern regions of the Yunnan Province book on Chinese herbal medicine " 1.: all wind skin of dispelling is itched.Control bones and muscles pain, phlegm-fire flaccidity is soft, brothers' clonic spasm of the muscle, and numb, diuresis, rushes down bladder accumulated heat, attacks loose all pyogenic infections from tumour or sore, moves back consumptive disease heat fever, controls wind-fire dental caries, the diseases such as varioliform exanthema mange.2. " detailed outline is picked up any lost article from the road ": remove wind, dredge through invigorating blood circulation, muscle reinforcing and bone strengthening, dredging collateral arteries and veins.Control damage, arthromyodynia, numb, Pi Feng, infusing drugs in wine is often drunk.3. " modern Practical Chinese medicinal ": only chronic dysentery, thick the intestines and stomach, spleen invigorating in tune.4. " Guizhou side's medicine among the people collection ": control traumatic injury, only knife injury is hemorrhage, again can cough-relieving, lung benefiting gas.5. " pharmacognosy ": heat-clearing and toxic substances removing.Control calentura to quench one's thirst, carbuncle skin ulcer swells.[extracts] " China's book on Chinese herbal medicine "

Herba Hyperici Patuli: [another name] Radix Hyperici Monogyni (Herba Hyperici Monogyni), pig thumb willow, Fructus Hyperici belli, Herba Hyperici Patuli, Hypericum beanii, SHANZHIZI, Hubei anemone, Lysimachia christinae Hance, great Ye Huang, limit, land for growing field crops Huang, Cladrastis kentukea Rudd, Jin Xiang, Dragon Boat Festival flower.[source] is the Herb of Garcinia maingayii Herba Hyperici Patuli.Latin plant animal mineral name: Hypericum patulumThunb.ex Murray [Norysca patula (Thunb.exMurray) J.Voigt].Gather and store: summer gathers, cleaning, chopping, dries.[nature and flavor] are bitter; Cold.[return through] liver; Kidney; Urinary bladder channel.[function cures mainly] clearing away heat-damp and promoting diuresis detoxifies; Dispersing the stagnated liver-QI and dredging collateral; Stasis-dispelling and pain-killing.Main damp and hot gonorrhea; Hepatitis; Flu; Tonsillitis; The hernia swelling and hanging down of either of the testes; Bones and muscles pain; Traumatic injury.[extracts] " China's book on Chinese herbal medicine "

Radix Linderae Glaucae: [source] is come from " Fujian traditional herbal medicine ".[another name] ox tendon strip root, root of Lindera glauca (Sieb. Et Zucc.) Blume, Thunder God are high, red autumnal leaves bavin, gold toothed oak.[source] medical material Ji Yuan: be the root of canella Fructus Linderae Glaucae.Latin plant animal mineral name: Lindera glauca (Sieb.et Zucc.) Bl.Gather and store: autumn gathers, drying.[nature and flavor] are pungent; Temperature; Bitter.[return through] liver; Stomach warp.[function cures mainly] dispelling wind and removing obstruction in the collateral; Vital energy regualting and blood circulation-promoting; Inducing diuresis and reducing edema; Preventing phlegm from forming and stopping coughing.Main air pain of dampness syndrome; Traumatic injury; Gastralgia; De-power impairment caused by overstrain; Bronchitis; Edema.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "

Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine preparation can be preferably as follows: Radix Habenariae Dentatae 30 ~ 40 parts, Caulis Fibraureae 40 ~ 50 parts, Rhizoma Panacis Majoris 20 ~ 30 parts, Coriolous Dersicolor (Fr.) Quel 10 ~ 20 parts, Herba nepenthis 10 ~ 20 parts, Folium glochidionis puberi 5 ~ 15 parts, Radix desmodiik microphylli 15 ~ 25 parts, Herba Aeschynonenes Indicae 10 ~ 20 parts, Radix Bischofiae Javanicae 20 ~ 30 parts, Herba Salviae Chinensis 30 ~ 40 parts, Herba Oberoniae iridifoliae 10 ~ 20 parts, Caulis et Folium fici Tikouae 20 ~ 30 parts, Radix Ampelopsis delavayanae 5 ~ 15 parts, Folium et cacumen Breyniae Fruticosae 5 ~ 15 parts, Herba Erodii 15 ~ 25 parts, Herba Hyperici Patuli 20 ~ 30 parts and Radix Linderae Glaucae 10 ~ 20 parts.

Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine preparation can be preferably as follows: Radix Habenariae Dentatae 35 ~ 40 parts, Caulis Fibraureae 45 ~ 50 parts, Rhizoma Panacis Majoris 25 ~ 30 parts, Coriolous Dersicolor (Fr.) Quel 15 ~ 20 parts, Herba nepenthis 10 ~ 15 parts, Folium glochidionis puberi 5 ~ 10 parts, Radix desmodiik microphylli 20 ~ 25 parts, Herba Aeschynonenes Indicae 10 ~ 15 parts, Radix Bischofiae Javanicae 25 ~ 30 parts, Herba Salviae Chinensis 30 ~ 35 parts, Herba Oberoniae iridifoliae 15 ~ 20 parts, Caulis et Folium fici Tikouae 20 ~ 25 parts, Radix Ampelopsis delavayanae 10 ~ 15 parts, Folium et cacumen Breyniae Fruticosae 5 ~ 10 parts, Herba Erodii 15 ~ 20 parts, Herba Hyperici Patuli 25 ~ 30 parts and Radix Linderae Glaucae 10 ~ 15 parts.

Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine preparation can be preferably as follows: Radix Habenariae Dentatae 36 parts, Caulis Fibraureae 50 parts, Rhizoma Panacis Majoris 27 parts, Coriolous Dersicolor (Fr.) Quel 18 parts, Herba nepenthis 12 parts, Folium glochidionis puberi 8 parts, Radix desmodiik microphylli 24 parts, Herba Aeschynonenes Indicae 11 parts, Radix Bischofiae Javanicae 27 parts, Herba Salviae Chinensis 34 parts, Herba Oberoniae iridifoliae 15 parts, Caulis et Folium fici Tikouae 23 parts, Radix Ampelopsis delavayanae 14 parts, Folium et cacumen Breyniae Fruticosae 6 parts, Herba Erodii 17 parts, Herba Hyperici Patuli 28 parts and Radix Linderae Glaucae 13 parts.

Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine preparation can be preferably as follows: Radix Habenariae Dentatae 39 parts, Caulis Fibraureae 47 parts, Rhizoma Panacis Majoris 28 parts, Coriolous Dersicolor (Fr.) Quel 16 parts, Herba nepenthis 15 parts, Folium glochidionis puberi 5 parts, Radix desmodiik microphylli 22 parts, Herba Aeschynonenes Indicae 13 parts, Radix Bischofiae Javanicae 29 parts, Herba Salviae Chinensis 32 parts, Herba Oberoniae iridifoliae 19 parts, Caulis et Folium fici Tikouae 25 parts, Radix Ampelopsis delavayanae 11 parts, Folium et cacumen Breyniae Fruticosae 9 parts, Herba Erodii 18 parts, Herba Hyperici Patuli 26 parts and Radix Linderae Glaucae 14 parts.

Wherein, when the dosage form of described Chinese medicine preparation is powder, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine preparation raw medicinal material, and adding relative to the determining alcohol of mixture quality 5 ~ 7 times is the ethanol of 65 ~ 75%, reflux 2 ~ 4 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 ~ 4 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds the starch relative to its quality 2 ~ 4 times in the micropowders obtained by second step, mixing, obtains powder.

Wherein, when the dosage form of described Chinese medicine preparation is oral solutions, its preparation method comprises the following steps:

The first step, Radix Habenariae Dentatae, Caulis Fibraureae, Rhizoma Panacis Majoris, Coriolous Dersicolor (Fr.) Quel, Herba nepenthis, Folium glochidionis puberi, Radix desmodiik microphylli, Herba Aeschynonenes Indicae and Radix Bischofiae Javanicae are mixed in proportion, be that the methanol of 70% ~ 80% is as solvent with determining alcohol, adopt percolation with the speed of 1 ~ 3ml per minute slowly percolation, collect percolate, concentrating under reduced pressure is also dry, obtains and gets dry extract, be ground into 200 ~ 300 object powder, the quality of the methanol added is 3 ~ 5 times of first step mixture quality;

Second step, is mixed in proportion surplus stock medical material, is ground into 100 ~ 200 object powder;

3rd step, in the powder that second step obtains, adds the distilled water of the powder quality 3 ~ 6 times obtained relative to second step, decocts 2 ~ 4 hours, filter, obtain the first filtrate; Filtering residue is added the distilled water relative to its quality 2 ~ 4 times, decoct 1 ~ 2 hour, filter, obtain the second filtrate; Merge the first filtrate and the second filtrate, concentrate away the water of 2/3 ~ 3/4 volume, add the ethanol that determining alcohol is 90 ~ 95%, make determining alcohol reach 70% ~ 80%, leave standstill 12 ~ 24 hours, filter, concentrating under reduced pressure, drying, obtains and gets dry extract, and is ground into 200 ~ 300 object powder;

4th step, the powder mixing first step and the 3rd step obtained, add the distilled water relative to mixed-powder quality 3 ~ 5 times amount, the sucrose of 0.1 ~ 0.3 times, the sodium benzoate of 0.01 ~ 0.02 times, stir, boil, cooling, filter, subpackage, namely sterilizing obtains oral liquid.

Below adopt embodiment to describe embodiments of the present invention in detail, fully understand how application technology means solve technical problem in the present invention whereby, reach technique effect and implement according to this.

Embodiment 1: powder

Get Radix Habenariae Dentatae 360g, Caulis Fibraureae 500g, Rhizoma Panacis Majoris 270g, Coriolous Dersicolor (Fr.) Quel 180g, Herba nepenthis 120g, Folium glochidionis puberi 80g, Radix desmodiik microphylli 240g, Herba Aeschynonenes Indicae 110g, Radix Bischofiae Javanicae 270g, Herba Salviae Chinensis 340g, Herba Oberoniae iridifoliae 150g, Caulis et Folium fici Tikouae 230g, Radix Ampelopsis delavayanae 140g, Folium et cacumen Breyniae Fruticosae 60g, Herba Erodii 170g, Herba Hyperici Patuli 280g and Radix Linderae Glaucae 130g.

Its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine preparation raw medicinal material, and adding relative to the determining alcohol of mixture quality 6 times is the ethanol of 70%, reflux 4 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 3 times again, reflux 2 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 hours, pulverize, sieve, obtain 400 object micropowders;

3rd step, adds the starch relative to its quality 3.4 times in the micropowders obtained by second step, mixing, obtains powder.

Embodiment 2: oral solutions

Get Radix Habenariae Dentatae 390g, Caulis Fibraureae 470g, Rhizoma Panacis Majoris 280g, Coriolous Dersicolor (Fr.) Quel 160g, Herba nepenthis 150g, Folium glochidionis puberi 50g, Radix desmodiik microphylli 220g, Herba Aeschynonenes Indicae 130g, Radix Bischofiae Javanicae 290g, Herba Salviae Chinensis 320g, Herba Oberoniae iridifoliae 190g, Caulis et Folium fici Tikouae 250g, Radix Ampelopsis delavayanae 110g, Folium et cacumen Breyniae Fruticosae 90g, Herba Erodii 180g, Herba Hyperici Patuli 260g and Radix Linderae Glaucae 140g.

Its preparation method comprises the following steps:

The first step, Radix Habenariae Dentatae, Caulis Fibraureae, Rhizoma Panacis Majoris, Coriolous Dersicolor (Fr.) Quel, Herba nepenthis, Folium glochidionis puberi, Radix desmodiik microphylli, Herba Aeschynonenes Indicae and Radix Bischofiae Javanicae are mixed in proportion, be that the methanol of 80% is as solvent with determining alcohol, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, concentrating under reduced pressure is also dry, obtains and gets dry extract, be ground into 300 object powder, the quality of the methanol added is 4.5 times of first step mixture quality;

Second step, is mixed in proportion surplus stock medical material, is ground into 200 object powder;

3rd step, in the powder that second step obtains, adds the distilled water of the powder quality 5 times obtained relative to second step, decocts 3 hours, filter, obtain the first filtrate; Filtering residue is added the distilled water relative to its quality 3 times, decoct 2 hours, filter, obtain the second filtrate; Merge the first filtrate and the second filtrate, concentrate away the water of 2/3 volume, add the ethanol that determining alcohol is 90%, make determining alcohol reach 75%, leave standstill 20 hours, filter, concentrating under reduced pressure, dry, obtain and get dry extract, be ground into 300 object powder;

4th step, the powder mixing first step and the 3rd step obtained, add the distilled water relative to mixed-powder quality 4 times amount, the sucrose of 0.25 times, the sodium benzoate of 0.015 times, stir, boil, cooling, filter, subpackage, namely sterilizing obtains oral liquid.

Toxicity test:

Acute toxicity testing: application mice 70, male and female half and half, body weight 20 ~ 26g, carries out acute toxicity testing.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese powder medicine prepared by embodiments of the invention 1, (concentration is 15.54g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 77.7 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage powder LD50>77.7 crude drug/kg of the present invention, every day, maximum dosage-feeding was 155.4 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 2.4g crude drug/day/chicken, grow up laying hen body weight in 1.8KG, average dosage is 1.333g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 23g) oral administration gavage Chinese medicine of the present invention is 117 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is low, clinical drug safety.

Long term toxicity test: Chinese medicine embodiment 1 powder of the present invention presses 4.82,9.32 and 17.42g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical experiment:

Laboratory animal: the Roman egghen 1750 of Linyi City suburb poultry specialist, in June, 2014, chicken group major part occurs that pain is uneasy, difficulty of laying eggs has pain, mostly with bloodstain on its eggshell of the egg of output, often discharge Huang, white pus sample secretions in fallopian tube, pollute perianal and feather below thereof.The phenomenons such as the appearance body temperature that part is serious raises, and sometimes in lethargy shape, does not rise sleepingly, and abdominal part of walking lands, and stand transfixed to the ground, two wings are sagging, and feather pine is random.Be diagnosed as salpingitis.By ill 1254, be divided into two groups at random, an experimental group (654) and a matched group (600).Experimental chicken is raised in cages, free choice feeding and drinking-water, conventional feeding and management.

Experimental technique:

Experimental group: first conventional raising 2 days.Then normal water, adds the Chinese powder medicine of the embodiment of the present invention 1, stirs in the normal feedstuff of feeding in the ratio of 2.5%, connect and feed 5 days.

Matched group: first conventional raising 2 days.Mixed drink: ovum health (Hebei cloud starts thing pharmaceutcal corporation, Ltd), is watered 1000L according to every 100g, every day 1-2 time, connects and feeds 5 days; Mixed feeding: add following composition in the normal feedstuff of feeding: every 100kg normal feedstuff adds 70g egg fowl many ovum element (Xinxiang, Henan Bai Yang animal husbandry group Bai Lan pharmacy branch company) and 100g egg good fortune (Xinxiang, Henan Bai Yang animal husbandry group Bai Lan pharmacy branch company), connects and feeds 5 days.

Observe statistical indicator: the situation of searching for food of observing chicken every day, record egg production, broken egg, soft egg, abnormal-shape egg quantity etc., add up the indexs such as each group of feed intake, laying rate, rate of broken eggs.

Curative effect determinate standard: cure: egg production becomes reconciled the recovery of egg rate normally, and mental status is good, and feather is normal, and fallopian tube is without pussy discharge; Effective: egg production egg rate of becoming reconciled is clearly better, mental status is good, and fallopian tube is without pussy discharge; Invalid: egg production egg rate of becoming reconciled does not change substantially, and mental status is without being clearly better, and fallopian tube still has pussy discharge.Wherein, effective percentage is the percentage ratio that healing number and significant figure account for sum.

Therapeutic outcome: treatment situation statistical result before and after treatment, in table 1; Before and after treatment, laying rate and the statistical result of good egg rate are in table 2.

Situation contrast treated by table 1 before and after treating as follows:

Group	Recovery from illness (only)	Effectively (only)	Invalid (only)	Effective percentage (%)
					Experimental group	482	142	30	95.4％
Matched group	308	195	97	83.8％

From the data of table 1, compared with matched group, use the Drug therapy Chicken salpingitis of the embodiment of the present invention, there is evident in efficacy, that cure rate is high advantage.

482 laying hens of simultaneously in two months subsequently, experimental group being cured and matched group 308 laying hen follow-up observations of curing 2 months, result is added up, and treatment group recurs 11, and relapse rate is 2.28%; Matched group recurs 48, relapse rate 15.58%.Difference has statistical significance (p<0.05), and experimental group relapse rate is lower than matched group.

Front and back laying rate treated by table 2 and the contrast of good egg rate is as follows:

From the data of table 2, the medicine of the embodiment of the present invention, compared with matched group, better can improve the egg production of ill chicken, laying rate becomes reconciled egg rate; Use Chinese medicine of the present invention, within about 3 days, laying rate gets final product rebound significantly, and the abnormal-shape egg such as husky preserved egg, soft egg, little egg obviously reduce, and laying rate egg rate of becoming reconciled within about 5 days, just can be made to return to state before laying hen disease, even better than state before sick.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (9)

1. treat the Chinese medicine preparation of hens salpingitis for one kind, it is characterized in that, each raw medicinal material of described Chinese medicine preparation comprises: Radix Habenariae Dentatae, Caulis Fibraureae, Rhizoma Panacis Majoris, Coriolous Dersicolor (Fr.) Quel, Herba nepenthis, Folium glochidionis puberi, Radix desmodiik microphylli, Herba Aeschynonenes Indicae, Radix Bischofiae Javanicae, Herba Salviae Chinensis, Herba Oberoniae iridifoliae, Caulis et Folium fici Tikouae, Radix Ampelopsis delavayanae, Folium et cacumen Breyniae Fruticosae, Herba Erodii, Herba Hyperici Patuli and Radix Linderae Glaucae.

2. Chinese medicine preparation as claimed in claim 1, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine preparation is as follows: Radix Habenariae Dentatae 30 ~ 40 parts, Caulis Fibraureae 40 ~ 50 parts, Rhizoma Panacis Majoris 20 ~ 30 parts, Coriolous Dersicolor (Fr.) Quel 10 ~ 20 parts, Herba nepenthis 10 ~ 20 parts, Folium glochidionis puberi 5 ~ 15 parts, Radix desmodiik microphylli 15 ~ 25 parts, Herba Aeschynonenes Indicae 10 ~ 20 parts, Radix Bischofiae Javanicae 20 ~ 30 parts, Herba Salviae Chinensis 30 ~ 40 parts, Herba Oberoniae iridifoliae 10 ~ 20 parts, Caulis et Folium fici Tikouae 20 ~ 30 parts, Radix Ampelopsis delavayanae 5 ~ 15 parts, Folium et cacumen Breyniae Fruticosae 5 ~ 15 parts, Herba Erodii 15 ~ 25 parts, Herba Hyperici Patuli 20 ~ 30 parts and Radix Linderae Glaucae 10 ~ 20 parts.

3. Chinese medicine preparation as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine preparation is as follows: Radix Habenariae Dentatae 35 ~ 40 parts, Caulis Fibraureae 45 ~ 50 parts, Rhizoma Panacis Majoris 25 ~ 30 parts, Coriolous Dersicolor (Fr.) Quel 15 ~ 20 parts, Herba nepenthis 10 ~ 15 parts, Folium glochidionis puberi 5 ~ 10 parts, Radix desmodiik microphylli 20 ~ 25 parts, Herba Aeschynonenes Indicae 10 ~ 15 parts, Radix Bischofiae Javanicae 25 ~ 30 parts, Herba Salviae Chinensis 30 ~ 35 parts, Herba Oberoniae iridifoliae 15 ~ 20 parts, Caulis et Folium fici Tikouae 20 ~ 25 parts, Radix Ampelopsis delavayanae 10 ~ 15 parts, Folium et cacumen Breyniae Fruticosae 5 ~ 10 parts, Herba Erodii 15 ~ 20 parts, Herba Hyperici Patuli 25 ~ 30 parts and Radix Linderae Glaucae 10 ~ 15 parts.

4. the Chinese medicine preparation as described in claims 1 to 3, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine preparation is as follows: Radix Habenariae Dentatae 36 parts, Caulis Fibraureae 50 parts, Rhizoma Panacis Majoris 27 parts, Coriolous Dersicolor (Fr.) Quel 18 parts, Herba nepenthis 12 parts, Folium glochidionis puberi 8 parts, Radix desmodiik microphylli 24 parts, Herba Aeschynonenes Indicae 11 parts, Radix Bischofiae Javanicae 27 parts, Herba Salviae Chinensis 34 parts, Herba Oberoniae iridifoliae 15 parts, Caulis et Folium fici Tikouae 23 parts, Radix Ampelopsis delavayanae 14 parts, Folium et cacumen Breyniae Fruticosae 6 parts, Herba Erodii 17 parts, Herba Hyperici Patuli 28 parts and Radix Linderae Glaucae 13 parts.

5. the Chinese medicine preparation as described in claims 1 to 3, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine preparation is as follows: Radix Habenariae Dentatae 39 parts, Caulis Fibraureae 47 parts, Rhizoma Panacis Majoris 28 parts, Coriolous Dersicolor (Fr.) Quel 16 parts, Herba nepenthis 15 parts, Folium glochidionis puberi 5 parts, Radix desmodiik microphylli 22 parts, Herba Aeschynonenes Indicae 13 parts, Radix Bischofiae Javanicae 29 parts, Herba Salviae Chinensis 32 parts, Herba Oberoniae iridifoliae 19 parts, Caulis et Folium fici Tikouae 25 parts, Radix Ampelopsis delavayanae 11 parts, Folium et cacumen Breyniae Fruticosae 9 parts, Herba Erodii 18 parts, Herba Hyperici Patuli 26 parts and Radix Linderae Glaucae 14 parts.

6. the Chinese medicine preparation as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine preparation is powder, and its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine preparation raw medicinal material, and adding relative to the determining alcohol of mixture quality 5 ~ 7 times is the ethanol of 65 ~ 75%, reflux 2 ~ 4 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 ~ 4 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds the starch relative to its quality 2 ~ 4 times in the micropowders obtained by second step, mixing, obtains powder.

7. the Chinese medicine preparation as described in claim 1 to 6, is characterized in that, the dosage form of described Chinese medicine preparation is oral solutions, and its preparation method comprises the following steps:

The first step, Radix Habenariae Dentatae, Caulis Fibraureae, Rhizoma Panacis Majoris, Coriolous Dersicolor (Fr.) Quel, Herba nepenthis, Folium glochidionis puberi, Radix desmodiik microphylli, Herba Aeschynonenes Indicae and Radix Bischofiae Javanicae are mixed in proportion, be that the methanol of 70% ~ 80% is as solvent with determining alcohol, adopt percolation with the speed of 1 ~ 3ml per minute slowly percolation, collect percolate, concentrating under reduced pressure is also dry, obtains and gets dry extract, be ground into 200 ~ 300 object powder, the quality of the methanol added is 3 ~ 5 times of first step mixture quality;

Second step, is mixed in proportion surplus stock medical material, is ground into 100 ~ 200 object powder;

3rd step, in the powder that second step obtains, adds the distilled water of the powder quality 3 ~ 6 times obtained relative to second step, decocts 2 ~ 4 hours, filter, obtain the first filtrate; Filtering residue is added the distilled water relative to its quality 2 ~ 4 times, decoct 1 ~ 2 hour, filter, obtain the second filtrate; Merge the first filtrate and the second filtrate, concentrate away the water of 2/3 ~ 3/4 volume, add the ethanol that determining alcohol is 90 ~ 95%, make determining alcohol reach 70% ~ 80%, leave standstill 12 ~ 24 hours, filter, concentrating under reduced pressure, drying, obtains and gets dry extract, and is ground into 200 ~ 300 object powder;

4th step, the powder mixing first step and the 3rd step obtained, add the distilled water relative to mixed-powder quality 3 ~ 5 times amount, the sucrose of 0.1 ~ 0.3 times, the sodium benzoate of 0.01 ~ 0.02 times, stir, boil, cooling, filter, subpackage, namely sterilizing obtains oral liquid.

8. a preparation method for Chinese medicine preparation described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine preparation is powder, and its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine preparation raw medicinal material, and adding relative to the determining alcohol of mixture quality 5 ~ 7 times is the ethanol of 65 ~ 75%, reflux 2 ~ 4 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 ~ 4 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds the starch relative to its quality 2 ~ 4 times in the micropowders obtained by second step, mixing, obtains powder.

9. a preparation method for Chinese medicine preparation described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine preparation is oral solutions, and its preparation method comprises the following steps:

The first step, Radix Habenariae Dentatae, Caulis Fibraureae, Rhizoma Panacis Majoris, Coriolous Dersicolor (Fr.) Quel, Herba nepenthis, Folium glochidionis puberi, Radix desmodiik microphylli, Herba Aeschynonenes Indicae and Radix Bischofiae Javanicae are mixed in proportion, be that the methanol of 70% ~ 80% is as solvent with determining alcohol, adopt percolation with the speed of 1 ~ 3ml per minute slowly percolation, collect percolate, concentrating under reduced pressure is also dry, obtains and gets dry extract, be ground into 200 ~ 300 object powder, the quality of the methanol added is 3 ~ 5 times of first step mixture quality;

Second step, is mixed in proportion surplus stock medical material, is ground into 100 ~ 200 object powder;

3rd step, in the powder that second step obtains, adds the distilled water of the powder quality 3 ~ 6 times obtained relative to second step, decocts 2 ~ 4 hours, filter, obtain the first filtrate; Filtering residue is added the distilled water relative to its quality 2 ~ 4 times, decoct 1 ~ 2 hour, filter, obtain the second filtrate; Merge the first filtrate and the second filtrate, concentrate away the water of 2/3 ~ 3/4 volume, add the ethanol that determining alcohol is 90 ~ 95%, make determining alcohol reach 70% ~ 80%, leave standstill 12 ~ 24 hours, filter, concentrating under reduced pressure, drying, obtains and gets dry extract, and is ground into 200 ~ 300 object powder;

4th step, the powder mixing first step and the 3rd step obtained, add the distilled water relative to mixed-powder quality 3 ~ 5 times amount, the sucrose of 0.1 ~ 0.3 times, the sodium benzoate of 0.01 ~ 0.02 times, stir, boil, cooling, filter, subpackage, namely sterilizing obtains oral liquid.