CN105816577A - Pharmaceutical composition for treating duck virus hepatitis and preparation method thereof - Google Patents
Pharmaceutical composition for treating duck virus hepatitis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a pharmaceutical composition for treating duck virus hepatitis and a preparation method thereof. The pharmaceutical composition is prepared from folium isatidis, fructus toosendan, herb of malay blumea, roots of rhodomyrtus tomentosa, brine alkali, fructus forsythia, herb of rupestrine dragonhead, diaphragma juglandis, Indian rorippa herb, radix panacis quinquefolii, licorice roots, plumula nelumbinis, amur barberry roots, bigleaf beautyberry roots, coriolus versicolor, pine leaves, all-grass of poisonous buttercrp herb, herbal swertiae mileensis, flos chrysanthemi, herbal taraxaci, herb of bentham dichrocephala, radix trichosanthis, folium apocyni veneti, semen cassiae, homlockleaved moonwort and herb of spanishneedles. The pharmaceutical composition has the advantages that antibacterial and anti-inflammation effects are achieved, the prevention and treatment effect on ducklings suffering from duck virus hepatitis is remarkable, yin and yang can be balanced, the cure rate is high, the treatment course is short, the quantity of medicine residues is small, and meanwhile the immunity and disease resistance of the ducklings can be enhanced.
Description
Technical field
The present invention relates to field of veterinary, particularly to a kind of pharmaceutical composition treating duck viral hepatitis and preparation method thereof.
Background technology
The acute infectious disease that duck viral hepatitis is mainly caused by DHV, its course of disease is short, and sickness rate is high, propagates fast, and mortality rate is high.DHV (DHV) has I, II, III 3 serotype, wherein I type, III type are that Picornaviridae enterovirus belongs to virus, II type is class Astrovirus, there is not cross-immunity between each serotype, mostly is I type DHV in the cause of disease that China is popular.This disease throughout the year in all have generation, but often occur in spring or winter, main by digestive tract, respiratory tract infection, duckling within many infringements 3 week old, also the duckling that can cause 4-6 week old falls ill, in 1 week old, the mortality rate of duckling is up to 95%, and the case fatality rate of 2-3 week old is not higher than 50%, and the later M & M of 4 week old is the most relatively low.
Clinical symptoms: spirit is depressed, and appetite is gradually reduced, feather is slightly the most unglazed, instability of gait, two wing shakes, dyspnea, diarrhoea, and the symptoms such as opisthotonus occur in row's yellow or celadon loose stool.Sick duck being cutd open inspection observe, pathological changes mainly has: liver enlargement, khaki, and there is hemorrhage speckle on surface；Indivedual also have necrosis region, and gollbladder dilation, spleen enlargement, there is mottling decorative pattern on surface；Kidney enlargement, has dendroid congested.
At present, the treatment to duck viral hepatitis mainly uses Western medicine, such as duck virus hepatitis yolk antibody, hyper-immune serum and monoclonal antibody.There is the shortcoming being difficult to preserve in high immunity yolk antibody, sometimes there is the most repeatedly injecting the situation of all difficult symptom management of high immunity yolk antibody, and, what the producing of major part yolk antibody used is not the Ovum Anas domestica that produced of specific pathogen free microorganism duck, thus cause pathogenic microorganism to pass to duck by yolk antibody, even be the Ovum Anas domestica that produced of specific pathogen free microorganism duck, because yolk itself is a kind of nutrient substance, during production if do not note sterile working or preserve improper, easily pollute pathogenic microorganism, cause transmission of disease.Hyper-immune serum and monoclonal antibody are due to expensive in short supply with the source of goods, and actual application is less.
It addition, the herbal medicine that can treat duck viral hepatitis on market is little, even if there have individual plants can prevent and treat duck liver to be scorching, but but there is easily recurrence and the disadvantage that can not effect a radical cure.
Compared with doctor trained in Western medicine, Chinese medicine not only cure rate is high, instant effect, and drug residue free, and cost price is low.Emphasizing to regulate allomeric function, improve the premunition of duck self, prolonged application is safe and reliable, can carry out marketing.
Summary of the invention
The technical problem to be solved is to be to provide a kind of pharmaceutical composition treating duck viral hepatitis, the pharmaceutical composition of the present invention has antibacterial, antiinflammation, to suffering from the prevention of duckling of duck viral hepatitis and treating evident in efficacy, can also Yin Yang balancing, cure rate is high, treatment short treating period, drug residue are low, can strengthen immunity and the resistance against diseases of duck simultaneously.
In order to realize foregoing invention purpose, the invention provides a kind of pharmaceutical composition treating duck viral hepatitis, described pharmaceutical composition includes following raw medicinal material: Folium Isatidis, Fructus Toosendan, Herba Blumeae Lacerae, mountain root, salt alkali, Fructus Forsythiae, Herba Dracocephali Rupestris, dish, Radix Panacis Quinquefolii, Radix Glycyrrhizae, Plumula Nelumbinis, Folium Callicarpae Formosanae, Coriolous Dersicolor (Fr.) Quel, Flos Chrysanthemi, Herba Taraxaci, Herba Houttuyniae, Radix Trichosanthis, Folium Apocyni Veneti, Semen Cassiae, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. and Herba Bidentis Bipinnatae.
nullIn described pharmaceutical composition, the ratio of weight and number of each raw medicinal material is: Folium Isatidis 15-25 weight portion、Fructus Toosendan 1-2 weight portion、Herba Blumeae Lacerae 12-32 weight portion、Mountain root 13-27 weight portion、Salt alkali 13-32 weight portion、Fructus Forsythiae 14-28 weight portion、Herba Dracocephali Rupestris's 12-22 weight portion、Dish 13-31 weight portion、Radix Panacis Quinquefolii 15-25 weight portion、Radix Glycyrrhizae 15-35 weight portion、Plumula Nelumbinis 12-42 weight portion、Folium Callicarpae Formosanae 10-20 weight portion、Coriolous Dersicolor (Fr.) Quel 14-26 weight portion、Flos Chrysanthemi 15-35 weight portion、Herba Taraxaci 15-25 weight portion、Herba Houttuyniae 13-33 weight portion、Radix Trichosanthis 12-24 weight portion、Folium Apocyni Veneti 14-32 weight portion、Semen Cassiae 17-38 weight portion、Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 14-22 weight portion and Herba Bidentis Bipinnatae 10-30 weight portion.
In described pharmaceutical composition, the ratio of weight and number of each raw medicinal material is: Folium Isatidis 22 weight portion, Fructus Toosendan 1 weight portion, Herba Blumeae Lacerae 30 weight portion, mountain root 24 weight portion, salt alkali 32 weight portion, Fructus Forsythiae 26 weight portion, Herba Dracocephali Rupestris 20 weight portion, dish 30 weight portion, Radix Panacis Quinquefolii 24 weight portion, Radix Glycyrrhizae 34 weight portion, Plumula Nelumbinis 40 weight portion, Folium Callicarpae Formosanae 15 weight portion, Coriolous Dersicolor (Fr.) Quel 22 weight portion, Flos Chrysanthemi 32 weight portion, Herba Taraxaci 20 weight portion, Herba Houttuyniae 32 weight portion, Radix Trichosanthis 24 weight portion, Folium Apocyni Veneti 31 weight portion, Semen Cassiae 35 weight portion, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 16 weight portion and Herba Bidentis Bipinnatae 25 weight portion.
Described pharmaceutical composition also includes: Folium Pini, Herba Ranunculi Scelerati (Radix Anemones rupicolae), Herba Swertiae Mileensis, Partition in Fructus Juglandis and Radix Berberidis Amurensis.
nullIn described pharmaceutical composition, the parts by weight of each raw medicinal material are: Folium Isatidis 15-25 weight portion、Fructus Toosendan 1-2 weight portion、Herba Blumeae Lacerae 12-32 weight portion、Mountain root 13-27 weight portion、Salt alkali 13-32 weight portion、Fructus Forsythiae 14-28 weight portion、Herba Dracocephali Rupestris's 12-22 weight portion、Dish 13-31 weight portion、Radix Panacis Quinquefolii 15-25 weight portion、Radix Glycyrrhizae 15-35 weight portion、Plumula Nelumbinis 12-42 weight portion、Folium Callicarpae Formosanae 10-20 weight portion、Coriolous Dersicolor (Fr.) Quel 14-26 weight portion、Flos Chrysanthemi 15-35 weight portion、Herba Taraxaci 15-25 weight portion、Herba Houttuyniae 13-33 weight portion、Radix Trichosanthis 12-24 weight portion、Folium Apocyni Veneti 14-32 weight portion、Semen Cassiae 17-38 weight portion、Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 14-22 weight portion、Herba Bidentis Bipinnatae 10-30 weight portion、Folium Pini 10-30 weight portion、Herba Ranunculi Scelerati (Radix Anemones rupicolae) 1-2 weight portion、Herba Swertiae Mileensis 13-24 weight portion、Partition in Fructus Juglandis 15-30 weight portion and Radix Berberidis Amurensis 17-33 weight portion.
In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Folium Isatidis 22 weight portion, Fructus Toosendan 1 weight portion, Herba Blumeae Lacerae 30 weight portion, mountain root 24 weight portion, salt alkali 32 weight portion, Fructus Forsythiae 26 weight portion, Herba Dracocephali Rupestris 20 weight portion, dish 30 weight portion, Radix Panacis Quinquefolii 24 weight portion, Radix Glycyrrhizae 34 weight portion, Plumula Nelumbinis 40 weight portion, Folium Callicarpae Formosanae 15 weight portion, Coriolous Dersicolor (Fr.) Quel 22 weight portion, Flos Chrysanthemi 32 weight portion, Herba Taraxaci 20 weight portion, Herba Houttuyniae 32 weight portion, Radix Trichosanthis 24 weight portion, Folium Apocyni Veneti 31 weight portion, Semen Cassiae 35 weight portion, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 16 weight portion, Herba Bidentis Bipinnatae 25 weight portion, Folium Pini 30 weight portion, Herba Ranunculi Scelerati (Radix Anemones rupicolae) 1 weight portion, Herba Swertiae Mileensis 23 weight portion, Partition in Fructus Juglandis 30 weight portion and Radix Berberidis Amurensis 27 weight portion.
The dosage form of described pharmaceutical composition is injectable powder, and its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into the mixed powder being ground into the micron particles of 0.1～10 μm volume average particle size and particle diameter in super micron mill less than the nano-scale particle composition of 0.1 μm volume average particle size, described mixed powder powder rate is at least 95%；
Second step, the ethanol that determining alcohol is 85%～95% of the quality 3 relative to described mixed powder～5 times is added in the mixed powder that the first step obtains, stirring and dissolving obtains ethanol solution, ethanol solution is stood 24～36 hours under conditions of 5 DEG C～10 DEG C, use percolation with per minute 1～2ml speed slowly percolation, collect percolate, it is concentrated and dried, and pulverizing 40～60 minutes in super micron mill are put at this, the micron particles and the particle diameter that obtain 0.1～10 μm volume average particle size are less than the mixed powder that the nano-scale particle of 0.1 μm volume average particle size forms, the powder rate that obtains of described mixed powder is at least 95%；
3rd step, takes mixed powder 10g～20g that second step obtains, and adds propylene glycol 30g～50g, adds 200ml water for injection, and stirring makes it dissolve, injects water to 1000ml further, add 1g～1.5g needle-use activated carbon, be sufficiently stirred for 30～50 minutes；Decarbonization filtering；With 0.22～0.24 μm filtering with microporous membrane；Lyophilization obtains sterilized powder, subpackage embedding.
The dosage form of described pharmaceutical composition is powder, and its preparation method comprises the following steps:
The first step, mountain root, salt alkali, Fructus Forsythiae, Herba Dracocephali Rupestris, dish and Radix Panacis Quinquefolii are mixed in described ratio, dissolves with the ethanol that determining alcohol is 85%～95% of 3～5 times of the mixture quality relative to acquisition, extract after being heated to reflux 2～4 hours, filter, obtain the first filtrate；Filtering residue is dissolved with the ethanol of the determining alcohol 85%～95% of 1～2 times of the mixture quality relative to acquisition again, extracts after being heated to reflux 1～2 hour, filter, obtain the second filtrate；Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.7～0.9g crude drug/mL, through the macroporous adsorptive resins eluting that volume is 5L, first with deionized water or the distilled water eluting of 5 times of resin column volumes, it is 90%～95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collecting ethanol elution, concentrating under reduced pressure removes ethanol, is dried and is ground into powder；
Second step, Radix Trichosanthis, Folium Apocyni Veneti, Semen Cassiae, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. and Herba Bidentis Bipinnatae are mixed in described ratio, add the ethanol of determining alcohol 85%～95% relative to 2～4 times of mixture quality obtained, heating and refluxing extraction 1～2 times, extracting solution merges, being centrifuged remove impurity with tube centrifuge, when the extracting solution after remove impurity is evaporated under conditions of 60 DEG C～70 DEG C 60 DEG C, relative density is the mastic of 1.20～1.23, and the mastic spray dryer after concentrating is dried to powder；
3rd step, is mixed surplus stock medical material in described ratio, adds the water dissolution relative to 2～4 times of mixture quality obtained, and heating decocts 2～4 hours, filters；By filtering residue again with the water dissolution of 1～2 times of the mixture quality relative to acquisition, again heating decoction 1～2 hour, filtration；Merging the filtrate of twice, concentrating under reduced pressure removes moisture, is dried and is ground into powder；
4th step, the powder mixing that the first step, second step and the 3rd step are obtained, it is screened into the fine powder of 80～120 mesh subsequently, the fine powder obtained is put in mixing and blending machine and stirs, i.e. obtain powder.
The invention has the beneficial effects as follows: the pharmaceutical composition of the present invention has antibacterial, antiinflammation, to suffering from the prevention of duckling of duck viral hepatitis and treating evident in efficacy, can also Yin Yang balancing, cure rate is high, treatment short treating period, drug residue are low, can strengthen immunity and the resistance against diseases of duck simultaneously.
Detailed description of the invention
The invention provides a kind of pharmaceutical composition treating duck viral hepatitis, including following raw medicinal material: Folium Isatidis, Fructus Toosendan, Herba Blumeae Lacerae, mountain root, salt alkali, Fructus Forsythiae, Herba Dracocephali Rupestris, Partition in Fructus Juglandis, dish, Radix Panacis Quinquefolii, Radix Glycyrrhizae, Plumula Nelumbinis, Radix Berberidis Amurensis, Folium Callicarpae Formosanae, Coriolous Dersicolor (Fr.) Quel, Folium Pini, Herba Ranunculi Scelerati (Radix Anemones rupicolae), Herba Swertiae Mileensis, Flos Chrysanthemi, Herba Taraxaci, Herba Houttuyniae, Radix Trichosanthis, Folium Apocyni Veneti, Semen Cassiae, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. and Herba Bidentis Bipinnatae.
The pharmacological property of above-mentioned each raw medicinal material is as follows:
Folium Callicarpae Formosanae: another name: Folium Callicarpae Formosanae, Folium Callicarpae Formosanae.Source: Verenaceae Callicarpa plant callicarpa pedunculata CallicarpapedunculataR.Brown and Callicarpa dichotoma C.dichotoma(Lour.) K.Koch., is used as medicine with stem, leaf and root.Spring, summer, autumn picking leaves and tender stem, using fresh herb or dry is ground into powder；The root four seasons can adopt, and section is dried.Nature and flavor: bitter, puckery are flat.Cure mainly: hemostasis, dissipating blood stasis, antiinflammatory.For epistaxis, spitting of blood, gastrointestinal hemorrhage, metrorrhagia, upper respiratory tract infection, tonsillitis, pneumonia, bronchitis；Traumatic hemorrhage is controlled in external, burn.
Radix Panacis Quinquefolii: source: this product is the dry root of Araliaceae Radix Panacis Quinquefolii PanaxquinquefoliumL..It is all cultivation product, excavates autumn, clean, dry or cold drying.Nature and flavor: hardship sweet, micro-are cool.Gui Jing: GUIXIN, lung, kidney channel.Cure mainly: boosting qi and nourishing yin, clearing away heat and promoting production of body fluid.For deficiency of vital energy yin deficiency, interior-heat, cough with asthma expectorant blood, deficiency-heat is tired of tired, quenches one's thirst, dryness of the mouth and throat.
Partition in Fructus Juglandis: another name: Semen Juglandis kind every.Source: this product is the wooden barrier film of juglandaceae plant Semen Juglandis JuglansregiaL..Nature and flavor: bitter, puckery are flat.Cure mainly: the kidney invigorating arresting seminal emission.For emission due to deficiency of the kidney, spermatorrhea, the enuresis.
Herba Houttuyniae: source: " the southern regions of the Yunnan Province book on Chinese herbal medicine ".Another name: star green bristlegrass grass, constellation grass (" the southern regions of the Yunnan Province book on Chinese herbal medicine " arranges this), three rosetangles (" Yunnan proved recipe of traditional Chinese medicine "), ground Fructus Piperis, drum fourth grass (" Yunnan Chinese herbal medicine ").Source: for the little Herba Houttuyniae of feverfew or the herb of chrysanthemum leaf Herba Houttuyniae.Summer gathers, and dries.Nature and flavor: " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " bitter in the mouth, cold in nature." cure mainly: heat-clearing and toxic substances removing, dampness removing, nebula of dispelling.Treating malaria disease, dysentery, diarrhoea, hepatitis, women leucorrhea, day nebula, aphtha, skin infection.1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " control children's's internal organs accumulated heat, person of rushing down clear water, smash juice, breast stewes clothes.Or smash juice order watery wine clothes, preventing the attack (or recurrence) of malaria." 2. " Yunnan Chinese herbal medicine ": " heat-clearing and toxic substances removing.Treating the liver is scorching, infantile dyspepsia, nyctalopia, skin infection." 3. " catalogue planted by Guizhou medicine ": " removing damp-heat, removing nebula of detoxifying.Control furuncle, mist, oral aphthae in children, women leucorrhea." 4. " choosing of Yunnan Chinese herbal medicine ": " heat-clearing and toxic substances removing, pain relieving, antidiarrheal.Cure cold high heat, diarrhoea, hepatitis."
Herba Swertiae Mileensis: another name: Swertia mileensis T.N. Ho et W. L. Shi, Fel Mylopharyngodon piceus, walk gallbladder medicine, Herba hedyotis costatae.Source: this product is gentianaceae plant Herba Swertiae Mileensis SwertiamileensisT.N.HeetW.L.Shi, dry herb.Autumn, flowering fruit bearing stage was gathered, and removes silt, dries.Nature and flavor: bitter, sweet, cold.Gui Jing: return liver, gallbladder, bladder warp.Cure mainly: liver heat removing function of gallbladder promoting, clearing away heat-damp and promoting diuresis.For jaundice dark coloured urine, the puckery pain of pyretic stranguria.
Herba Bidentis Bipinnatae: source: supplement to the Herbal.Nature and flavor: 1. supplement to the Herbal: " bitter in the mouth, flat, nontoxic." 2. " Quanzhou book on Chinese herbal medicine ": " is warm in nature, and bitter in the mouth is nontoxic." cure mainly: heat clearing away, removing toxic substances, dissipating blood stasis, detumescence.Treating malaria disease, diarrhoea, dysentery, hepatitis, acute nephritis, stomachache, dysphagic, acute appendicitis, laryngopharynx swelling and pain, traumatic injury, snake bite and insect sting.1. " this leather is picked up any lost article from the road ": " main Serpentis and Aranea sting, and pestle is broken applies it, also pestle strand juice clothes." 2. " detailed outline ": " is coated with scorpion a kind of scorpion wound." 3. " Fujian traditional herbal medicine ": " removing blood stasis and activating blood flow, eliminating carbuncle detoxifies." 4. " medicine will is planted in Jiangsu ": " is smash juice and is applied, hemostasis." 5. " illustrated handbook planted by middle traditional Chinese medicines ": " decoction, controls dysentery, the secondary pain of throat, dysphagia and regurgitation, the disease such as cardiospasm and esophagectasia.There are removing toxic substances, antidiarrheal, antipyretic effect.Near with controlling cecitis." 6. " Quanzhou book on Chinese herbal medicine ": " repercussive, analgesia, hold back incised wound.Controlling trusted subordinate and tie pain, postnatal blood stasis, menstruation is obstructed, and incised wound is hemorrhage, enterorrhagia, hemorrhagic dysentery, hematuria." 7. " east, Fujian book on Chinese herbal medicine ": " controls acute appendicitis, stranguria with turbid discharge, malaria, jaundice, dysuria, traumatic injury."
Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw.: source: " Shaanxi Chinese herbal medicine ".Another name: YIDUOYUN (" Shaanxi Chinese herbal medicine ").Source: for the whole herb with root of Botrychiaceae plant Herba pteridii latiusculi Cai.Spring, winter excavate, and dry or using fresh herb.Nature and flavor: " Shaanxi Chinese herbal medicine ": " pained, cool." curing mainly: 1. " Shaanxi Chinese herbal medicine ": " heat-clearing and toxic substances removing, suppressing the hyperactive liver eliminating stagnation.Control lung abscess, conjunctivitis, impairment caused by overstrain, venom, scrofula." 2. Nanchuan " conventional Chinese herbal medicine handbook ": " qi-restoratives lung moistening, relieving cough and resolving phlegm.Control cough, weak and celostomia after being ill."
Radix Trichosanthis: source: this product is cucurbitaceous plant Fructus Trichosanthis TrichosantheskirilowiiMaxim. or the dry root of trichosanthes rosthornii Harms Trichosan-thesrosthorniiHerms.Autumn, season in winter two excavate, and clean, and remove crust, and cutting or vertical profile become lobe, are dried.Nature and flavor: hardship sweet, micro-, are slightly cold.Gui Jing: attach to the lung and stomach meridians.Cure mainly: clearing away heat and promoting production of body fluid, detumescence and apocenosis.For calentura excessive thirst, lung-heat type cough, interior-heat quenches one's thirst, sore swollen toxin.
Folium Pini: source: Collective Notes to the Canon of Materia medica.Another name: bristles Folium Pini (Holy Benevolent Prescriptions), Folium Pini (" easy folk prescription "), illawarra mountain pine palpus (" the SHENGCAO property of medicine is standby to be wanted "), Folium Pini (Guangzhou army " conventional Chinese herbal medicine handbook ").Source: for pinaceae plant Pinus tabuliformis or the leaf of Pinus massoniana Lamb, pinus yunnanensis faranch etc..The whole year can adopt, and with twelfth month, the person of adopting is best.Dry after adopting, place and be dried place.Nature and flavor: 1. " not Lu ": " bitter in the mouth, temperature." 2. " Japan hanako materia medica ": " warms up, nontoxic." return through: " book on Chinese herbal medicine is the newest ": " enters the heart, spleen two warp." cure mainly: dispeiling pathogenic wind and removing dampness, parasite killing, antipruritic.Dispelling the wind and dampness pathogens flaccidity syndrome and arthralgia syndrome, traumatic injury, insomnia, edema, eczema, scabies.And epidemic encephalitis, influenza, ancylostomiasis can be prevented and treated.
Coriolous Dersicolor (Fr.) Quel: another name: Coriolus Versicolor, yellow Coriolous Dersicolor (Fr.) Quel, ash sesame, watt bacterium, bright cloud leather lid bacterium, polychrome bolete, red see hands, thousand layers of mushroom, lathe work Coriolous Dersicolor (Fr.) Quel.Source: medical material Ji Yuan: for the sporophore of On Polyporaceae Corilus versicolor Quel..Latin plant animal mineral name: Coriolusversicolor (L.exFr.) Quel. [Polystictusversicolor (L.) Fr.], gathers and stores: the whole year all can gather, and removes impurity, dries.Nature and flavor: sweet；Light；It is slightly cold.Gui Jing: liver；Spleen；Lung meridian.Cure mainly: invigorating spleen to remove dampness；Relieving cough and asthma；Heat-clearing and toxic substances removing；Antitumor..
Fructus Toosendan: source: " book on Chinese herbal medicine is just ".Another name: chinaberry is real (" herbal classic "), practices real (Collective Notes to the Canon of Materia medica), Fructus Toosendan.Core Fructus Jujubae (Hou Ningji " medicine spectrum "), Fructus Toosendan (" Bencao Tujing)).Source: for the fruit of canella Fructus Toosendan.Nature and flavor: bitter, cold, poisonous.1. " herbal classic ": " bitter, cold." 2. " not Lu ": " be slightly poisonous." 3. " pearl sac ": " acid, bitter." 4. " medical center bun is wanted ": " core: toil；Cold." return through: enter liver, stomach, small intestine meridian.Cure mainly: dehumidifying heat, clearing away liver-fire, pain relieving, parasite killing.Control epigastric pain with cold limbs due to adverseness of heat, hypochondriac pain, colic, abdominal pain due to worm stagnation.
Plumula Nelumbinis: source: " feeding habits book on Chinese herbal medicine ".Another name: the heart of a lotus seed (" elegant "), the bitter heart of a lotus seed (" Bencao Tujing "), the lotus heart of a lotus seed (" detailed outline "), Plumula Nelumbinis (" book on Chinese herbal medicine is the newest ").Source: for the green plumule of the mature seed of nymphaeaceae plant lotus.Gather autumn Semen Nelumbinis time, strip from Semen Nelumbinis, dry.Nature and flavor: bitter, cold.1. land pearl not exactly round in shape " poem coloured glaze ": " taste is the most bitter." 2. " detailed outline ": " is bitter, cold, nontoxic." 3. " Chongqing hall random notes ": " sweetness and bitterness is salty." return through: " book on Chinese herbal medicine is the newest ": " enters the heart, lung, kidney three warp." cure mainly: clear away heart-fire, reduce phlegm and internal heat, hemostasis, arresting seminal emission.Control vexed, thirsty, spit blood, seminal emission, conjunctival congestion and swelling pain." this leather is the newest ": " lung-fire, drops in clearing away heart-fire, suppressing the hyperactive liver fire, purgation of spleen excess fire.Relieving summer heat relieving restlessness, raw rule is quenched the thirst, and controls mesh red and swollen."
Folium Apocyni Veneti: another name: bluish dogbane, Herba Euphorbiae Helioscopiae Folium Camelliae sinensis numb, wild, Arisaema balansae Engl. grass.Source: for the leaf of apocynaceae plant Herba Apocyni veneti ApocynumvenetumL..Summer gathers, and removes impurity, is dried.Nature and flavor: cool in nature, sweet in the mouth, hardship.Cure mainly: clearing away liver-fire, suppressing the hyperactive liver to relieve the wind syndrome.Headache dizziness, convulsion with spasms for liver fire exuberance.This product has the effect reduced blood pressure.
Dish: another name: wild herbs, ferrum colza, sarson, Herba Rorippae, barbarea, Semen vignae sinensis.Source: Cruciferae Lepidium plant dish Rorippamontana(Wall.) Small or Herba Rorippae Rorippaindica(L.) Hiern., with all herbal medicine.Xia Qiu gathers, and dries.Nature and flavor: sweet, light are cool.Cure mainly: heat-clearing and toxic substances removing, antitussive, diuresis.For cold, fever, laryngopharynx swelling and pain, cough due to lung-heat, chronic tracheitis, acute rheumatic arthritis, hepatitis, dysuria；Dermatitis rhus, venom, furuncle carbuncle are controlled in external.
Salt alkali: source: for salt block through the powder being processed into.Nature and flavor: salty, bitter, temperature.Cure mainly: heart tonifying, diuresis, calm, antiinflammatory, blood pressure lowering.
Herba Blumeae Lacerae: another name: Hemerocallis citrina Baroni Scabrous Elephantfoot Herb.Source: Compositae Herba Blumeae Balsamiferae platymiscium is shown in the herb of the yellow BlumealaceraDC. of frost.Spring and summer is gathered, and clean chopping is dried, or fresh leaf.Nature and flavor: bitter, cold.Cure mainly: heat-clearing and toxic substances removing, reducing swelling and alleviating pain.For tonsillitis, stomatitis, gingival abscess, mumps, infantile pneumonia；Ulcerative carbuncle toxic swelling, skin pruritus are controlled in external.
Flos Chrysanthemi: another name: Flos Chrysanthemi, Flos Chrysanthemi, chamomile, medicine chrysanthemum, Ramulus et Folium Mussaendae Pubescentis chrysanthemum, tea chrysanthemum, Flos Chrysanthemi, Flos Chrysanthemi, in the least chrysanthemum, Flos Chrysanthemi, Flos Chrysanthemi.Source: this product is the dry capitulum of feverfew chrysanthemum ChrysanthemummorifoliumRamat..9～gather when spending in full bloom November in batches, dry in the shade or dry, or smoked, steam after dry.Medical material is different with processing method by the place of production, is divided into " Flos Chrysanthemi ", " Flos Chrysanthemi ", " Flos Chrysanthemi ", " Flos Chrysanthemi ".Nature and flavor: sweet, bitter, are slightly cold.Gui Jing: return lung, Liver Channel.Cure mainly: dissipate wind heat clearing away, suppressing the hyperactive liver improving eyesight.For anemopyretic cold, dizziness of having a headache, conjunctival congestion and swelling pain, eyes is dim-sighted.
Fructus Forsythiae: another name: Fructus Forsythiae, Hemerocallis citrina Baroni bar, yellow chain barriness, Huang Qidan, green grass or young crops stick up, fall to sticking up.Nature and flavor: bitter, are slightly cold.Gui Jing: return lung, the heart, small intestine meridian.Cure mainly: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.For carbuncle, scrofula, acute mastitis, erysipelas, anemopyretic cold, epidemic febrile disease from the beginning of, warm is joined the army, high hot excessive thirst, and coma sends out speckle, pyretic stranguria urine retention.
Radix Glycyrrhizae: source: this product is glycyrrhizic legume GlycyrrhizauralensisFisch., Glycyrrhiza inflata Bat. GlycyrrhizainflataBat. or the dry root of Glycyrrhiza glabra L. GlycyrrhizaglabraL..Spring, season in autumn two excavate, and remove fibrous root, dry.Nature and flavor: sweet are flat.Gui Jing: GUIXIN, lung, spleen, stomach warp.Cure mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, extremity contraction urgency pain, carbuncle sore tumefacting virus, cushion toxicity, strong.
Folium Isatidis: source: this product is the dried leaves of cruciferae isatis IsatisindigoticaFort..In the summer, divide in season in autumn two 2～3 times and gather, remove impurity, dry.Nature and flavor: bitter, cold.Gui Jing: GUIXIN, stomach warp.Cure mainly: heat-clearing and toxic substances removing, blood cooling and ecchymoses removing.Join the army for pathogenic warmth, unconsciousness due to high fever, send out speckle dermexanthesis, jaundice, hematodiarrhoea, mumps, sore throat, erysipelas, carbuncle.
Semen Cassiae: source: " herbal classic ".Another name: Semen Cassiae, sheep bright (" WU Pu Bencao "), Cornu Caprae seu Ovis (" the most refined "), Horse hoof Semen Cassiae (TAO Hong-Jing), also gb 1 (" medical science main story "), bullshit bean (" the SHENGCAO property of medicine is standby to be wanted "), false Semen phaseoli radiati (" will planted by middle traditional Chinese medicines "), Horse hoof (" medicine will is planted in Jiangsu "), Herba Senecionis Scandentis (" Shanxi Chinese medicinal herbal)), celery is determined (" Shaanxi Chinese medicinal herbal "), swordweed (" Guangdong Chinese medicine "), wild Semen phaseoli radiati (" Jiangxi medical herbs "), Os Sus domestica is bright, pig dung indigo plant bean, spire Herba crotalariae mucronatae, rock at night, sheep tail bean (" the main poisonous plants in south ").Source: for the mature seed of leguminous plant Semen Cassiae.Autumn gathers after fruit maturation, Herb cuts off or takes fruit pod, dries, get seed, raise clean pod shell and impurity, then dry.Nature and flavor: bitter sweet are cool.1. " herbal classic ": " salty in the mouth is flat." 2. " not Lu ": " be bitter sweet, is slightly cold, nontoxic." 3. " book on Chinese herbal medicine is just ": " mildly bitter flavor is micro-sweet, and property is put down, micro-cool." return through: enter liver, kidney channel.1. " Thunder God concocts property of medicine solution ": " enter Liver Channel." 2. " Bencao Jingshu ": " liver meridian, also enters gallbladder, kidney." cure mainly: liver heat removing, improving eyesight, diuretic, relieving constipation.Control wind heat acute conjunctivitis, optic atrohic blindness, nyctalopia, hypertension, hepatitis, cirrhotic ascites, habitual constipation.
Herba Ranunculi Scelerati (Radix Anemones rupicolae): another name: without hair smallage, duck palm, water violet, water cucumber perfume, hammer of beating a gong, delicate fragrance grass.Source: for Ranunculaceae ranunculus Herba Ranunculi Scelerati (Radix Anemones rupicolae) RanunculussceleratusL., with all herbal medicine.Summer gathers, and cleans and dries or using fresh herb.Nature and flavor: bitter, pungent are flat.Poisonous.Cure mainly: detumescence, eliminating stagnation of drawing out pus by applying a plaster to the affected part, preventing the attack (or recurrence) of malaria.For tuberculous lymphadenitis, malaria, carbuncle, venom, chronic ulcer of the lower limb.
Herba Dracocephali Rupestris: source: " plateau Chinese herbal treatment handbook ".Another name: Ha Dun-Bi Yanggu (illiteracy name), that crow Huang is (Tibetan name).Source: for the herb of labiate Herba Dracocephali Rupestris.7～adopt herb August, clean, dry.Nature and flavor: Gan Xin is cool.1. " plateau Chinese herbal treatment handbook ": " pungent, cool." 2. " Inner Mongol Chinese herbal medicine ": " sweetness and bitterness, flat." return through: " plateau Chinese herbal treatment handbook ": " enters lung, stomach, spleen three warp." cure mainly: heat clearing and inflammation relieving, cooling blood for hemostasis.Control affection due to external wind and heat, cold and heat of having a headache, laryngalgia, cough, icterohepatitis, spit blood, epistaxis, dysentery.1. " plateau Chinese herbal treatment handbook ": " antipyretic antiinflammatory.Control headache due to pathogenic wind-heat, laryngalgia cough, diseases caused by exogenous pathogenic factor folder food, fullness in the epigastrium and chest." 2. " Inner Mongol Chinese herbal medicine ": " heat clearing and damp drying, cool liver is stopped blooding.Control headache, jaundice, spit blood, epistaxis, pharyngalgia, dysentery."
Mountain root: source: " the SHENGCAO property of medicine is standby to be wanted ".Another name: hilllock root (" full exhibition a collection of selected materials infectious disease ").Source: for myrtaceous of ma Tao Pen section plant.The whole year can adopt, using fresh herb or dry.Nature and flavor: sweet, micro-acid, temper.1. Guangzhou army " conventional Chinese herbal medicine handbook ": " sweet puckery, flat." 2. " Fujian Chinese herbal medicine ": " is micro-misery, temperature." cure mainly: dehumidifying is dispeled the wind, hemostasis, pain relieving.Treating the liver is scorching, metrorrhagia, stomachache, rheumatic arthritis, hernia, and hemorrhoid are scalded.1. " the SHENGCAO property of medicine is standby to be wanted ": " control pained." 2. " Guangxi Chinese medicinal herbal ": " cures the wound cold, invasion of the blood-chamber by heat." 3. " south of the Five Ridges herbal ": " Xie Jiure does not moves back."
Radix Berberidis Amurensis: another name: Radix Berberidis, Canis familiaris L. milk, vinegar slip, Ci Ci slips, Radix Berberidis soulieanae, Radix Berberidis anhweiensis.Source: for Berberidaceae berberis porcupine quill BerberisjulianaeSchneid, little Rhizoma Coptidis thorn B.wilsonaeHemsl., berberis poiretii B.poiretiiSchneid., yellow calamite (Amur Barberry Root) B.amurensisRupr. or the root of its other kind of congener, root bark, stem and peel of stem.Spring, autumn excavate, and remove branch and leaf, fibrous root and earth, are peeled by skin, cut into slices respectively, dry standby.Nature and flavor: bitter, cold.Cure mainly: heat clearing and damp drying, eliminating fire and detoxication.For bacillary dysentery, gastroenteritis, paratyphoid fever, dyspepsia, jaundice, cirrhotic ascites, urinary system infection, acute nephritis, tonsillitis, stomatitis, bronchitis；Otitis media, conjunctival congestion and swelling pain, trauma infection contamination are controlled in external.
Herba Taraxaci: another name: Herba crotalariae albidae, Po Poding.Source: this product is feverfew Herba Taraxaci TaraxacummongolicumHand.-Mazz., alkali ground Herba Taraxaci TaraxacumsinicumKitag. or belong to the dry herb of several plants together.Spend spring to autumn and excavate when just opening, remove impurity, clean, dry.Nature and flavor: bitter, sweet, cold.Gui Jing: return liver, stomach warp.Cure mainly: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome.For furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.
nullIn described pharmaceutical composition, the ratio of weight and number of each raw medicinal material is: Folium Isatidis 15-25 weight portion、Fructus Toosendan 1-2 weight portion、Herba Blumeae Lacerae 12-32 weight portion、Mountain root 13-27 weight portion、Salt alkali 13-32 weight portion、Fructus Forsythiae 14-28 weight portion、Herba Dracocephali Rupestris's 12-22 weight portion、Dish 13-31 weight portion、Radix Panacis Quinquefolii 15-25 weight portion、Radix Glycyrrhizae 15-35 weight portion、Plumula Nelumbinis 12-42 weight portion、Folium Callicarpae Formosanae 10-20 weight portion、Coriolous Dersicolor (Fr.) Quel 14-26 weight portion、Flos Chrysanthemi 15-35 weight portion、Herba Taraxaci 15-25 weight portion、Herba Houttuyniae 13-33 weight portion、Radix Trichosanthis 12-24 weight portion、Folium Apocyni Veneti 14-32 weight portion、Semen Cassiae 17-38 weight portion、Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 14-22 weight portion and Herba Bidentis Bipinnatae 10-30 weight portion.
In described pharmaceutical composition, the ratio of weight and number of each raw medicinal material is: Folium Isatidis 22 weight portion, Fructus Toosendan 1 weight portion, Herba Blumeae Lacerae 30 weight portion, mountain root 24 weight portion, salt alkali 32 weight portion, Fructus Forsythiae 26 weight portion, Herba Dracocephali Rupestris 20 weight portion, dish 30 weight portion, Radix Panacis Quinquefolii 24 weight portion, Radix Glycyrrhizae 34 weight portion, Plumula Nelumbinis 40 weight portion, Folium Callicarpae Formosanae 15 weight portion, Coriolous Dersicolor (Fr.) Quel 22 weight portion, Flos Chrysanthemi 32 weight portion, Herba Taraxaci 20 weight portion, Herba Houttuyniae 32 weight portion, Radix Trichosanthis 24 weight portion, Folium Apocyni Veneti 31 weight portion, Semen Cassiae 35 weight portion, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 16 weight portion and Herba Bidentis Bipinnatae 25 weight portion.
nullIn described pharmaceutical composition, the parts by weight of each raw medicinal material are: Folium Isatidis 15-25 weight portion、Fructus Toosendan 1-2 weight portion、Herba Blumeae Lacerae 12-32 weight portion、Mountain root 13-27 weight portion、Salt alkali 13-32 weight portion、Fructus Forsythiae 14-28 weight portion、Herba Dracocephali Rupestris's 12-22 weight portion、Dish 13-31 weight portion、Radix Panacis Quinquefolii 15-25 weight portion、Radix Glycyrrhizae 15-35 weight portion、Plumula Nelumbinis 12-42 weight portion、Folium Callicarpae Formosanae 10-20 weight portion、Coriolous Dersicolor (Fr.) Quel 14-26 weight portion、Flos Chrysanthemi 15-35 weight portion、Herba Taraxaci 15-25 weight portion、Herba Houttuyniae 13-33 weight portion、Radix Trichosanthis 12-24 weight portion、Folium Apocyni Veneti 14-32 weight portion、Semen Cassiae 17-38 weight portion、Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 14-22 weight portion、Herba Bidentis Bipinnatae 10-30 weight portion、Folium Pini 10-30 weight portion、Herba Ranunculi Scelerati (Radix Anemones rupicolae) 1-2 weight portion、Herba Swertiae Mileensis 13-24 weight portion、Partition in Fructus Juglandis 15-30 weight portion and Radix Berberidis Amurensis 17-33 weight portion.
In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Folium Isatidis 22 weight portion, Fructus Toosendan 1 weight portion, Herba Blumeae Lacerae 30 weight portion, mountain root 24 weight portion, salt alkali 32 weight portion, Fructus Forsythiae 26 weight portion, Herba Dracocephali Rupestris 20 weight portion, dish 30 weight portion, Radix Panacis Quinquefolii 24 weight portion, Radix Glycyrrhizae 34 weight portion, Plumula Nelumbinis 40 weight portion, Folium Callicarpae Formosanae 15 weight portion, Coriolous Dersicolor (Fr.) Quel 22 weight portion, Flos Chrysanthemi 32 weight portion, Herba Taraxaci 20 weight portion, Herba Houttuyniae 32 weight portion, Radix Trichosanthis 24 weight portion, Folium Apocyni Veneti 31 weight portion, Semen Cassiae 35 weight portion, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 16 weight portion, Herba Bidentis Bipinnatae 25 weight portion, Folium Pini 30 weight portion, Herba Ranunculi Scelerati (Radix Anemones rupicolae) 1 weight portion, Herba Swertiae Mileensis 23 weight portion, Partition in Fructus Juglandis 30 weight portion and Radix Berberidis Amurensis 27 weight portion.
The dosage form of described pharmaceutical composition is injectable powder, and its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into the mixed powder being ground into the micron particles of 0.1～10 μm volume average particle size and particle diameter in super micron mill less than the nano-scale particle composition of 0.1 μm volume average particle size, described mixed powder powder rate is at least 95%；
Second step, the ethanol that determining alcohol is 85%～95% of the quality 3 relative to described mixed powder～5 times is added in the mixed powder that the first step obtains, stirring and dissolving obtains ethanol solution, ethanol solution is stood 24～36 hours under conditions of 5 DEG C～10 DEG C, use percolation with per minute 1～2ml speed slowly percolation, collect percolate, it is concentrated and dried, and pulverizing 40～60 minutes in super micron mill are put at this, the micron particles and the particle diameter that obtain 0.1～10 μm volume average particle size are less than the mixed powder that the nano-scale particle of 0.1 μm volume average particle size forms, the powder rate that obtains of described mixed powder is at least 95%；
3rd step, takes mixed powder 10g～20g that second step obtains, and adds propylene glycol 30g～50g, adds 200ml water for injection, and stirring makes it dissolve, injects water to 1000ml further, add 1g～1.5g needle-use activated carbon, be sufficiently stirred for 30～50 minutes；Decarbonization filtering；With 0.22～0.24 μm filtering with microporous membrane；Lyophilization obtains sterilized powder, subpackage embedding.
The dosage form of described pharmaceutical composition is powder, and its preparation method comprises the following steps:
The first step, mountain root, salt alkali, Fructus Forsythiae, Herba Dracocephali Rupestris, dish and Radix Panacis Quinquefolii are mixed in described ratio, dissolves with the ethanol that determining alcohol is 85%～95% of 3～5 times of the mixture quality relative to acquisition, extract after being heated to reflux 2～4 hours, filter, obtain the first filtrate；Filtering residue is dissolved with the ethanol of the determining alcohol 85%～95% of 1～2 times of the mixture quality relative to acquisition again, extracts after being heated to reflux 1～2 hour, filter, obtain the second filtrate；Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.7～0.9g crude drug/mL, through the macroporous adsorptive resins eluting that volume is 5L, first with deionized water or the distilled water eluting of 5 times of resin column volumes, it is 90%～95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collecting ethanol elution, concentrating under reduced pressure removes ethanol, is dried and is ground into powder；
Second step, Radix Trichosanthis, Folium Apocyni Veneti, Semen Cassiae, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. and Herba Bidentis Bipinnatae are mixed in described ratio, add the ethanol of determining alcohol 85%～95% relative to 2～4 times of mixture quality obtained, heating and refluxing extraction 1～2 times, extracting solution merges, being centrifuged remove impurity with tube centrifuge, when the extracting solution after remove impurity is evaporated under conditions of 60 DEG C～70 DEG C 60 DEG C, relative density is the mastic of 1.20～1.23, and the mastic spray dryer after concentrating is dried to powder；
3rd step, is mixed surplus stock medical material in described ratio, adds the water dissolution relative to 2～4 times of mixture quality obtained, and heating decocts 2～4 hours, filters；By filtering residue again with the water dissolution of 1～2 times of the mixture quality relative to acquisition, again heating decoction 1～2 hour, filtration；Merging the filtrate of twice, concentrating under reduced pressure removes moisture, is dried and is ground into powder；
4th step, the powder mixing that the first step, second step and the 3rd step are obtained, it is screened into the fine powder of 80～120 mesh subsequently, the fine powder obtained is put in mixing and blending machine and stirs, i.e. obtain powder.
Hereinafter using embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the process that realizes reaching technique effect can fully understand and implement according to this.
Embodiment 1 pharmaceutical composition 1
Embodiments provide a kind of pharmaceutical composition treating duck viral hepatitis, it is made up of the raw medicinal material of following parts by weight: Folium Isatidis 22 weight portion, Fructus Toosendan 1 weight portion, Herba Blumeae Lacerae 30 weight portion, mountain root 24 weight portion, salt alkali 32 weight portion, Fructus Forsythiae 26 weight portion, Herba Dracocephali Rupestris 20 weight portion, dish 30 weight portion, Radix Panacis Quinquefolii 24 weight portion, Radix Glycyrrhizae 34 weight portion, Plumula Nelumbinis 40 weight portion, Folium Callicarpae Formosanae 15 weight portion, Coriolous Dersicolor (Fr.) Quel 22 weight portion, Flos Chrysanthemi 32 weight portion, Herba Taraxaci 20 weight portion, Herba Houttuyniae 32 weight portion, Radix Trichosanthis 24 weight portion, Folium Apocyni Veneti 31 weight portion, Semen Cassiae 35 weight portion, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 16 weight portion and Herba Bidentis Bipinnatae 25 weight portion.
Its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into the mixed powder being ground into the micron particles of 3 μm volume average particle size and particle diameter in super micron mill less than the nano-scale particle composition of 0.1 μm volume average particle size, described mixed powder powder rate is at least 95%；
Second step, the ethanol that determining alcohol is 90% of the quality 4 times relative to described mixed powder is added in the mixed powder that the first step obtains, stirring and dissolving obtains ethanol solution, ethanol solution is stood 30 hours under conditions of 9 DEG C, use percolation with the speed slowly percolation of 2ml per minute, collect percolate, it is concentrated and dried, and pulverizing 50 minutes in super micron mill are put at this, the micron particles and the particle diameter that obtain 4 μm volume average particle size are less than the mixed powder that the nano-scale particle of 0.1 μm volume average particle size forms, the powder rate that obtains of described mixed powder is at least 95%；
3rd step, takes the mixed powder 15g that second step obtains, and adds propylene glycol 40g, adds 200ml water for injection, and stirring makes it dissolve, injects water to 1000ml further, add 1.5g needle-use activated carbon, be sufficiently stirred for 40 minutes；Decarbonization filtering；With 0.23 μm filtering with microporous membrane；Lyophilization obtains sterilized powder, subpackage embedding.
Embodiment 2 pharmaceutical composition 2
nullEmbodiments provide a kind of pharmaceutical composition treating duck viral hepatitis，It is made up of the raw medicinal material of following parts by weight: Folium Isatidis 22 weight portion、Fructus Toosendan 1 weight portion、Herba Blumeae Lacerae 30 weight portion、Mountain root 24 weight portion、Salt alkali 32 weight portion、Fructus Forsythiae 26 weight portion、Herba Dracocephali Rupestris 20 weight portion、Dish 30 weight portion、Radix Panacis Quinquefolii 24 weight portion、Radix Glycyrrhizae 34 weight portion、Plumula Nelumbinis 40 weight portion、Folium Callicarpae Formosanae 15 weight portion、Coriolous Dersicolor (Fr.) Quel 22 weight portion、Flos Chrysanthemi 32 weight portion、Herba Taraxaci 20 weight portion、Herba Houttuyniae 32 weight portion、Radix Trichosanthis 24 weight portion、Folium Apocyni Veneti 31 weight portion、Semen Cassiae 35 weight portion、Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 16 weight portion、Herba Bidentis Bipinnatae 25 weight portion、Folium Pini 30 weight portion、Herba Ranunculi Scelerati (Radix Anemones rupicolae) 1 weight portion、Herba Swertiae Mileensis 23 weight portion、Partition in Fructus Juglandis 30 weight portion and Radix Berberidis Amurensis 27 weight portion.
Its preparation method is as follows:
The first step, is mixed mountain root, salt alkali, Fructus Forsythiae, Herba Dracocephali Rupestris, dish and Radix Panacis Quinquefolii in described ratio, dissolves with the ethanol that determining alcohol is 90% of 4 times of the mixture quality relative to acquisition, extracts after being heated to reflux 3 hours, filters, obtain the first filtrate；Filtering residue is dissolved with the ethanol of the determining alcohol 90% of 2 times of the mixture quality relative to acquisition again, extracts after being heated to reflux 2 hours, filter, obtain the second filtrate；Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.8g crude drug/mL, through the macroporous adsorptive resins eluting that volume is 5L, first with deionized water or the distilled water eluting of 5 times of resin column volumes, it is 90% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collecting ethanol elution, concentrating under reduced pressure removes ethanol, is dried and is ground into powder；
Second step, Radix Trichosanthis, Folium Apocyni Veneti, Semen Cassiae, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. and Herba Bidentis Bipinnatae are mixed in described ratio, add the ethanol of determining alcohol 90% relative to 3 times of mixture quality obtained, heating and refluxing extraction 2 times, extracting solution merges, being centrifuged remove impurity with tube centrifuge, it is the mastic of 1.22 that the extracting solution after remove impurity is evaporated under conditions of 65 DEG C relative density when 60 DEG C, and the mastic spray dryer after concentrating is dried to powder；
3rd step, is mixed surplus stock medical material in described ratio, adds the water dissolution relative to 3 times of mixture quality obtained, and heating decocts 3 hours, filters；By filtering residue again with the water dissolution of 1.5 times of the mixture quality relative to acquisition, again heating decoction 1.5 hours, filtration；Merging the filtrate of twice, concentrating under reduced pressure removes moisture, is dried and is ground into powder；
4th step, the powder mixing that the first step, second step and the 3rd step are obtained, it is screened into the fine powder of 100 mesh subsequently, the fine powder obtained is put in mixing and blending machine and stirs, i.e. obtain powder.
The toxicity test of pharmaceutical composition:
1, trial drug
Choose Folium Isatidis 22g, Fructus Toosendan 1g, Herba Blumeae Lacerae 30g, mountain root 24g, salt alkali 32g, Fructus Forsythiae 26g, Herba Dracocephali Rupestris 20g, dish 30g, Radix Panacis Quinquefolii 24g, Radix Glycyrrhizae 34g, Plumula Nelumbinis 40g, Folium Callicarpae Formosanae 15g, Coriolous Dersicolor (Fr.) Quel 22g, Flos Chrysanthemi 32g, Herba Taraxaci 20g, Herba Houttuyniae 32g, Radix Trichosanthis 24g, Folium Apocyni Veneti 31g, Semen Cassiae 35g, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 16g and Herba Bidentis Bipinnatae 25g mixing, be ground into powder；To obtain powder and add immersion 25 hours in 1400g cold water, with slow fire boiling, decocting time is 1.5 hours, decoction liquor is filtered, it is thus achieved that the first filtrate, collects filtering residue；Again add in 1400g cold water by filtering the filtering residue obtained, with slow fire boiling 3 times, decoct 1 hour every time, filter and merge filtrate, it is thus achieved that the second filtrate；Merging twice filtrate, concentrating under reduced pressure removes part water, it is thus achieved that decoction, the crude drug concentration of decoction is 3g/ml.
2, test method: select SD rat, give the decoction of the pharmaceutical composition of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, last is administered latter 24 hours respectively to organize to live and kills 1/2 animal (male and female half and half), and remaining 1/2 animal lives after continuing to observe 2 weeks and kills.Observe the outward appearance of animal, general behavior, food ration, body weight change during test, be administered latter 90 days and drug withdrawal carries out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crca, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology for 2 weeks.Result of the test shows: the pharmaceutical composition of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change the most without exception；Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all between normal range, group without significant difference；Each group main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively the 180 of clinical medicine dose, 60,20 times, pharmaceutical composition according to the result of the test present invention is administered at high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) and has no significant effect rat for continuous 90 days, without clear and definite toxicity target organ and sensitive indicator, convalescent period observes and also has no retardance toxic reaction, and the dose safety of the pharmaceutical composition clinical practice of the prompting present invention is higher.
Clinical trial
(1) material prepares
Experiment duck and place are chosen:
17 the duck fields selecting In Chaohu City, Anhui Province are Experimental Base, randomly select 1 age in days duckling 180, as treatment contrast test object.Separately randomly select the healthy 1 age in days duckling 180 in these 17 duck fields to be only used as preventing contrast test object.
(2) bacterial strain extracts:
The duck that dies of illness 20 duck viral hepatitiss of 17 duckeries in In Chaohu City, Anhui Province cuts open inspection, the aseptic thymus of disease duck, the liver taked, and bone marrow, spleen etc. are organized, the pathological material of disease sterilizing PBS gathered is ground, at dual anti-37 DEG C of final concentration 1000 μ/ml, acts on 30min, multigelation 3-4 time, centrifugal, supernatant adds 50% volume fraction chloroform give 15min, and period not failure of oscillation shakes, and 70 DEG C process 5min, centrifugal, supernatant, through 0.22 μm membrane filtration, sets low temperature refrigerator frozen, standby.
(3) prevention contrast experiment:
The 180 of random choose 1 week old health ducklings are randomly divided into 3 groups (embodiment 1 group, embodiment 2 groups and matched groups), wherein, embodiment 1 group, embodiment 2 groups and matched group use the injectable powder of the embodiment of the present invention 1, the powder of embodiment 2 and conventional medicament to prevent respectively；Wherein, injectable powder uses subcutaneous injection, each 10mg/kg, twice daily, injects 6 days continuously；The using method of powder is according in the part by weight conventional feed of 3g:100g by powder, feeds 6 days continuously；Matched group 1 and embodiment group carrying out artificial challenge with 5 times of diluents of standby culture, only, observed and recorded respectively organizes sickness rate and the mortality rate of duck to lumbar injection 0.3mL/, and result is as shown in table 1.
Table 1 preventive effect synopsis
| Group | Sum | Artificial challenge's number | Sickness rate | Death toll | Mortality rate | Protective rate |
| Embodiment 1 group | 60 | 60 | 0% | 0 | 0% | 100% |
| Embodiment 2 groups | 60 | 60 | 0% | 0 | 0% | 100% |
| Matched group | 60 | 0 | 24% | 0 | 40% | 60% |
Knowable to the data of table 1: the feedstuff containing pharmaceutical composition of the present invention has obvious preventive effect to treatment duck viral hepatitis.
(4) treatment contrast test:
It is randomly divided into three groups (embodiment group, western medicine group, blank groups) with 180 1 week old ducklings of the supernatant lumbar injection filtered, taking different medicine after there is clinical symptoms, wherein, embodiment group selects the pharmaceutical composition 1 of embodiment 1, dose be every every day 0.5g, treat 6 days；Western medicine group selects amantadine oral liquid oral medication, 1ml is administered orally every time, every day 2 times, is used in conjunction 6 days.Carry out neck injection, treat 6 days；Blank group does not feed any medicine.Observed and recorded respectively organizes the sickness rate of meat-type duck, cure rate and mortality rate, and result is as shown in table 2.
Table 2 therapeutic effect synopsis
| Group | Morbidity number | Sickness rate | Death toll | Mortality rate | Cure number | Cure rate |
| Embodiment group | 60 | 100% | 0 | 0% | 60 | 100% |
| Western medicine group | 60 | 100% | 12 | 20% | 48 | 80% |
| Blank group | 60 | 100% | 30 | 50% | - | - |
Knowable to the data of table 2: pharmaceutical composition of the present invention is substantially better than western medicine group to the therapeutic effect of duck viral hepatitis, reduce mortality rate, improve cure rate.
Model case:
The duckling of 300 1 week old of Taian Shandong ducks specialized household raising in by the end of December, 2014, nearly 100 duckling spirit are depressed, and appetite is gradually reduced, and feather is slightly the most unglazed, instability of gait, two wing shakes, dyspnea, diarrhoea, row's yellow or celadon loose stool, the symptoms such as opisthotonus occur.Selecting a wherein seriously ill duckling to dissect, find liver enlargement, khaki, there is hemorrhage speckle on surface；Indivedual also have necrosis region, and gollbladder dilation, spleen enlargement, there is mottling decorative pattern on surface；Kidney enlargement, has dendroid congested.Take the pathological material of diseases such as the heart of ill duckling, liver, spleen and shred grinding, make 1: 5 with sterile saline and be diluted to suspension, after adding penicillin and streptomycin process, be inoculated in the duck embryo chorioallantoic cavity of 1 week old, every duck embryonic breeding kind 0.5ml, after 3-5 days, duck embryo is dead, cuts open the dead duck embryo of inspection, find gollbladder dilation, there is mottling decorative pattern on surface, has dendroid congested, is diagnosed as acute duck viral hepatitis.Immediately duckling symptom do not occur is isolated raising place.Choose 50 ill ducklings therein, start to feed the feedstuff being added with the embodiment of the present invention 2 powder, powder is mixed in conventional feed according to 3:100 weight ratio, feed 6 days, within 2nd day, ill duckling symptom is obviously improved, and within the 3rd day, 50 ducklings are all fully recovered, after continuing to feed 4 days, compared with healthy duckling, average weight is essentially identical.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all within the spirit and principles in the present invention, any modification, equivalent substitution and improvement etc. made, should be included within the scope of the present invention.
Claims (10)
1. the pharmaceutical composition treating duck viral hepatitis, it is characterized in that, described pharmaceutical composition includes following raw medicinal material: Folium Isatidis, Fructus Toosendan, Herba Blumeae Lacerae, mountain root, salt alkali, Fructus Forsythiae, Herba Dracocephali Rupestris, dish, Radix Panacis Quinquefolii, Radix Glycyrrhizae, Plumula Nelumbinis, Folium Callicarpae Formosanae, Coriolous Dersicolor (Fr.) Quel, Flos Chrysanthemi, Herba Taraxaci, Herba Houttuyniae, Radix Trichosanthis, Folium Apocyni Veneti, Semen Cassiae, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. and Herba Bidentis Bipinnatae.
nullThe pharmaceutical composition for the treatment of duck viral hepatitis the most according to claim 1，It is characterized in that，In described pharmaceutical composition, the ratio of weight and number of each raw medicinal material is: Folium Isatidis 15-25 weight portion、Fructus Toosendan 1-2 weight portion、Herba Blumeae Lacerae 12-32 weight portion、Mountain root 13-27 weight portion、Salt alkali 13-32 weight portion、Fructus Forsythiae 14-28 weight portion、Herba Dracocephali Rupestris's 12-22 weight portion、Dish 13-31 weight portion、Radix Panacis Quinquefolii 15-25 weight portion、Radix Glycyrrhizae 15-35 weight portion、Plumula Nelumbinis 12-42 weight portion、Folium Callicarpae Formosanae 10-20 weight portion、Coriolous Dersicolor (Fr.) Quel 14-26 weight portion、Flos Chrysanthemi 15-35 weight portion、Herba Taraxaci 15-25 weight portion、Herba Houttuyniae 13-33 weight portion、Radix Trichosanthis 12-24 weight portion、Folium Apocyni Veneti 14-32 weight portion、Semen Cassiae 17-38 weight portion、Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 14-22 weight portion and Herba Bidentis Bipinnatae 10-30 weight portion.
The pharmaceutical composition for the treatment of duck viral hepatitis the most according to claim 1 and 2, it is characterized in that, in described pharmaceutical composition, the ratio of weight and number of each raw medicinal material is: Folium Isatidis 22 weight portion, Fructus Toosendan 1 weight portion, Herba Blumeae Lacerae 30 weight portion, mountain root 24 weight portion, salt alkali 32 weight portion, Fructus Forsythiae 26 weight portion, Herba Dracocephali Rupestris 20 weight portion, dish 30 weight portion, Radix Panacis Quinquefolii 24 weight portion, Radix Glycyrrhizae 34 weight portion, Plumula Nelumbinis 40 weight portion, Folium Callicarpae Formosanae 15 weight portion, Coriolous Dersicolor (Fr.) Quel 22 weight portion, Flos Chrysanthemi 32 weight portion, Herba Taraxaci 20 weight portion, Herba Houttuyniae 32 weight portion, Radix Trichosanthis 24 weight portion, Folium Apocyni Veneti 31 weight portion, Semen Cassiae 35 weight portion, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 16 weight portion and Herba Bidentis Bipinnatae 25 weight portion.
4. according to the pharmaceutical composition of the treatment duck viral hepatitis described in any one of claim 1-3, it is characterised in that described pharmaceutical composition also includes: Folium Pini, Herba Ranunculi Scelerati (Radix Anemones rupicolae), Herba Swertiae Mileensis, Partition in Fructus Juglandis and Radix Berberidis Amurensis.
null5. according to the pharmaceutical composition of the treatment duck viral hepatitis described in any one of claim 1-4，It is characterized in that，In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Folium Isatidis 15-25 weight portion、Fructus Toosendan 1-2 weight portion、Herba Blumeae Lacerae 12-32 weight portion、Mountain root 13-27 weight portion、Salt alkali 13-32 weight portion、Fructus Forsythiae 14-28 weight portion、Herba Dracocephali Rupestris's 12-22 weight portion、Dish 13-31 weight portion、Radix Panacis Quinquefolii 15-25 weight portion、Radix Glycyrrhizae 15-35 weight portion、Plumula Nelumbinis 12-42 weight portion、Folium Callicarpae Formosanae 10-20 weight portion、Coriolous Dersicolor (Fr.) Quel 14-26 weight portion、Flos Chrysanthemi 15-35 weight portion、Herba Taraxaci 15-25 weight portion、Herba Houttuyniae 13-33 weight portion、Radix Trichosanthis 12-24 weight portion、Folium Apocyni Veneti 14-32 weight portion、Semen Cassiae 17-38 weight portion、Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 14-22 weight portion、Herba Bidentis Bipinnatae 10-30 weight portion、Folium Pini 10-30 weight portion、Herba Ranunculi Scelerati (Radix Anemones rupicolae) 1-2 weight portion、Herba Swertiae Mileensis 13-24 weight portion、Partition in Fructus Juglandis 15-30 weight portion and Radix Berberidis Amurensis 17-33 weight portion.
null6. according to the pharmaceutical composition of the treatment duck viral hepatitis described in any one of claim 1-5，It is characterized in that，In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Folium Isatidis 22 weight portion、Fructus Toosendan 1 weight portion、Herba Blumeae Lacerae 30 weight portion、Mountain root 24 weight portion、Salt alkali 32 weight portion、Fructus Forsythiae 26 weight portion、Herba Dracocephali Rupestris 20 weight portion、Dish 30 weight portion、Radix Panacis Quinquefolii 24 weight portion、Radix Glycyrrhizae 34 weight portion、Plumula Nelumbinis 40 weight portion、Folium Callicarpae Formosanae 15 weight portion、Coriolous Dersicolor (Fr.) Quel 22 weight portion、Flos Chrysanthemi 32 weight portion、Herba Taraxaci 20 weight portion、Herba Houttuyniae 32 weight portion、Radix Trichosanthis 24 weight portion、Folium Apocyni Veneti 31 weight portion、Semen Cassiae 35 weight portion、Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 16 weight portion、Herba Bidentis Bipinnatae 25 weight portion、Folium Pini 30 weight portion、Herba Ranunculi Scelerati (Radix Anemones rupicolae) 1 weight portion、Herba Swertiae Mileensis 23 weight portion、Partition in Fructus Juglandis 30 weight portion and Radix Berberidis Amurensis 27 weight portion.
7. according to the pharmaceutical composition of the treatment duck viral hepatitis described in any one of claim 1-6, it is characterised in that the dosage form of described pharmaceutical composition is injectable powder, and its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into the mixed powder being ground into the micron particles of 0.1～10 μm volume average particle size and particle diameter in super micron mill less than the nano-scale particle composition of 0.1 μm volume average particle size, described mixed powder powder rate is at least 95%；
Second step, the ethanol that determining alcohol is 85%～95% of the quality 3 relative to described mixed powder～5 times is added in the mixed powder that the first step obtains, stirring and dissolving obtains ethanol solution, ethanol solution is stood 24～36 hours under conditions of 5 DEG C～10 DEG C, use percolation with per minute 1～2ml speed slowly percolation, collect percolate, it is concentrated and dried, and pulverizing 40～60 minutes in super micron mill are put at this, the micron particles and the particle diameter that obtain 0.1～10 μm volume average particle size are less than the mixed powder that the nano-scale particle of 0.1 μm volume average particle size forms, the powder rate that obtains of described mixed powder is at least 95%；
3rd step, takes mixed powder 10g～20g that second step obtains, and adds propylene glycol 30g～50g, adds 200ml water for injection, and stirring makes it dissolve, injects water to 1000ml further, add 1g～1.5g needle-use activated carbon, be sufficiently stirred for 30～50 minutes；Decarbonization filtering；With 0.22～0.24 μm filtering with microporous membrane；Lyophilization obtains sterilized powder, subpackage embedding.
8. according to the pharmaceutical composition of the treatment duck viral hepatitis described in any one of claim 1-6, it is characterised in that the dosage form of described pharmaceutical composition is powder, and its preparation method comprises the following steps:
The first step, mountain root, salt alkali, Fructus Forsythiae, Herba Dracocephali Rupestris, dish and Radix Panacis Quinquefolii are mixed in described ratio, dissolves with the ethanol that determining alcohol is 85%～95% of 3～5 times of the mixture quality relative to acquisition, extract after being heated to reflux 2～4 hours, filter, obtain the first filtrate；Filtering residue is dissolved with the ethanol of the determining alcohol 85%～95% of 1～2 times of the mixture quality relative to acquisition again, extracts after being heated to reflux 1～2 hour, filter, obtain the second filtrate；Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.7～0.9g crude drug/mL, through the macroporous adsorptive resins eluting that volume is 5L, first with deionized water or the distilled water eluting of 5 times of resin column volumes, it is 90%～95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collecting ethanol elution, concentrating under reduced pressure removes ethanol, is dried and is ground into powder；
Second step, Radix Trichosanthis, Folium Apocyni Veneti, Semen Cassiae, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. and Herba Bidentis Bipinnatae are mixed in described ratio, add the ethanol of determining alcohol 85%～95% relative to 2～4 times of mixture quality obtained, heating and refluxing extraction 1～2 times, extracting solution merges, being centrifuged remove impurity with tube centrifuge, when the extracting solution after remove impurity is evaporated under conditions of 60 DEG C～70 DEG C 60 DEG C, relative density is the mastic of 1.20～1.23, and the mastic spray dryer after concentrating is dried to powder；
3rd step, is mixed surplus stock medical material in described ratio, adds the water dissolution relative to 2～4 times of mixture quality obtained, and heating decocts 2～4 hours, filters；By filtering residue again with the water dissolution of 1～2 times of the mixture quality relative to acquisition, again heating decoction 1～2 hour, filtration；Merging the filtrate of twice, concentrating under reduced pressure removes moisture, is dried and is ground into powder；
4th step, the powder mixing that the first step, second step and the 3rd step are obtained, it is screened into the fine powder of 80～120 mesh subsequently, the fine powder obtained is put in mixing and blending machine and stirs, i.e. obtain powder.
9. according to the pharmaceutical composition of the treatment duck viral hepatitis described in any one of claim 1-6, it is characterised in that the dosage form of described pharmaceutical composition is injectable powder, and its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into the mixed powder being ground into the micron particles of 0.1～10 μm volume average particle size and particle diameter in super micron mill less than the nano-scale particle composition of 0.1 μm volume average particle size, described mixed powder powder rate is at least 95%；
Second step, the ethanol that determining alcohol is 85%～95% of the quality 3 relative to described mixed powder～5 times is added in the mixed powder that the first step obtains, stirring and dissolving obtains ethanol solution, ethanol solution is stood 24～36 hours under conditions of 5 DEG C～10 DEG C, use percolation with per minute 1～2ml speed slowly percolation, collect percolate, it is concentrated and dried, and pulverizing 40～60 minutes in super micron mill are put at this, the micron particles and the particle diameter that obtain 0.1～10 μm volume average particle size are less than the mixed powder that the nano-scale particle of 0.1 μm volume average particle size forms, the powder rate that obtains of described mixed powder is at least 95%；
3rd step, takes mixed powder 10g～20g that second step obtains, and adds propylene glycol 30g～50g, adds 200ml water for injection, and stirring makes it dissolve, injects water to 1000ml further, add 1g～1.5g needle-use activated carbon, be sufficiently stirred for 30～50 minutes；Decarbonization filtering；With 0.22～0.24 μm filtering with microporous membrane；Lyophilization obtains sterilized powder, subpackage embedding.
10. the preparation method of the pharmaceutical composition of the treatment duck viral hepatitis as described in any one of claim 1-6, it is characterised in that the dosage form of described pharmaceutical composition is powder, and its preparation method comprises the following steps:
The first step, mountain root, salt alkali, Fructus Forsythiae, Herba Dracocephali Rupestris, dish and Radix Panacis Quinquefolii are mixed in described ratio, dissolves with the ethanol that determining alcohol is 85%～95% of 3～5 times of the mixture quality relative to acquisition, extract after being heated to reflux 2～4 hours, filter, obtain the first filtrate；Filtering residue is dissolved with the ethanol of the determining alcohol 85%～95% of 1～2 times of the mixture quality relative to acquisition again, extracts after being heated to reflux 1～2 hour, filter, obtain the second filtrate；Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.7～0.9g crude drug/mL, through the macroporous adsorptive resins eluting that volume is 5L, first with deionized water or the distilled water eluting of 5 times of resin column volumes, it is 90%～95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collecting ethanol elution, concentrating under reduced pressure removes ethanol, is dried and is ground into powder；
Second step, Radix Trichosanthis, Folium Apocyni Veneti, Semen Cassiae, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. and Herba Bidentis Bipinnatae are mixed in described ratio, add the ethanol of determining alcohol 85%～95% relative to 2～4 times of mixture quality obtained, heating and refluxing extraction 1～2 times, extracting solution merges, being centrifuged remove impurity with tube centrifuge, when the extracting solution after remove impurity is evaporated under conditions of 60 DEG C～70 DEG C 60 DEG C, relative density is the mastic of 1.20～1.23, and the mastic spray dryer after concentrating is dried to powder；
3rd step, is mixed surplus stock medical material in described ratio, adds the water dissolution relative to 2～4 times of mixture quality obtained, and heating decocts 2～4 hours, filters；By filtering residue again with the water dissolution of 1～2 times of the mixture quality relative to acquisition, again heating decoction 1～2 hour, filtration；Merging the filtrate of twice, concentrating under reduced pressure removes moisture, is dried and is ground into powder；
4th step, the powder mixing that the first step, second step and the 3rd step are obtained, it is screened into the fine powder of 80～120 mesh subsequently, the fine powder obtained is put in mixing and blending machine and stirs, i.e. obtain powder.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106511813A (en) * | 2016-12-14 | 2017-03-22 | 合肥和源农业科技有限公司 | Drug for treating duck virus hepatitis |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104189565A (en) * | 2014-08-17 | 2014-12-10 | 严中明 | Traditional Chinese medicine composition for preventing and treating duck viral hepatitis |
| CN104906502A (en) * | 2015-05-18 | 2015-09-16 | 山东新希望六和集团有限公司 | Pharmaceutical composition for treatment of chicken damaged by heat and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104189565A (en) * | 2014-08-17 | 2014-12-10 | 严中明 | Traditional Chinese medicine composition for preventing and treating duck viral hepatitis |
| CN104906502A (en) * | 2015-05-18 | 2015-09-16 | 山东新希望六和集团有限公司 | Pharmaceutical composition for treatment of chicken damaged by heat and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106511813A (en) * | 2016-12-14 | 2017-03-22 | 合肥和源农业科技有限公司 | Drug for treating duck virus hepatitis |
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