CN105664026A - Medicine composition for treating infant spleen-deficiency type diarrhea and preparing method of medicine composition - Google Patents

Medicine composition for treating infant spleen-deficiency type diarrhea and preparing method of medicine composition Download PDF

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CN105664026A
CN105664026A CN201610087641.4A CN201610087641A CN105664026A CN 105664026 A CN105664026 A CN 105664026A CN 201610087641 A CN201610087641 A CN 201610087641A CN 105664026 A CN105664026 A CN 105664026A
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herba
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pharmaceutical composition
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李可亮
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/55—Glands not provided for in groups A61K35/22 - A61K35/545, e.g. thyroids, parathyroids or pineal glands
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    • A61K36/03—Phaeophycota or phaeophyta (brown algae), e.g. Fucus
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Abstract

The invention discloses a medicine composition for treating infant spleen-deficiency type diarrhea and a preparing method of the medicine composition. The medicine composition is prepared from crinite uraria herb, musk, seaweed, snow of June herb, patience dock roots, fortune silene herb with roots, lily, rhizoma curcumae, common coltsfoot flowers, asiatic bilberry leaves, fructus hippophae, semen cassiae, slivery aleuritopteris herb, obcordate christia herb, plumeria acutifolia flowers, lucid ganoderma, officinal magnolia bark, panax notoginseng, bovista, diaphragma juglandis fructus, Chinese tinospora stems, spores of lepisorus waltonii (Ching) Ching, garlic, roots or leaves or fruits of zanthoxylum avicennae (Lam.)DC., yam, water chestnuts, nudicaulous poppy fruits or herb with flowers, manyprickle acanthopanax roots, glabrousleaf pittosporum seeds, boschniakia rossica, violet herba and fruits or leaves of vitis flexuosa thunb. The medicine composition for treating infant spleen-deficiency type diarrhea and the preparing method of the medicine composition have the advantages that the medicine composition has the effects of regulating vital energy and regulating the middle warmer, tonifying the spleen and invigorating the stomach, relaxing the bowels and clearing away heat and promoting diuresis, also has the functions of protecting the intestine and stomach mucosa, promoting appetite, enhancing resistance and arresting pain, and is fast in effect taking, high in effective rate, definite in treatment effect, short in treatment course, free of toxic or side effects, low in price and the like.

Description

A kind of pharmaceutical composition treating infant spleen-deficient diarrhoea and preparation method thereof
Technical field
The present invention relates to technical field of medicine, particularly to a kind of pharmaceutical composition treating infant spleen-deficient diarrhoea and preparation method thereof.
Background technology
Infantile diarrhea, has another name called infantile dyspepsia, is a kind of acute gastrointestinal dysfunction of infantile period, based on the syndrome of diarrhoea, vomiting, the highest with summer and autumn sickness rate. Primary disease paathogenic factor is divided into three aspects: body constitution, infection and digestive functional disturbance. Clinical main manifestations be times of defecation increase, passage of loose stools and Electrolyte imbalance. Primary disease treatment is not in time so that occurring serious Electrolyte imbalance can jeopardize children's's life.
The cause of disease of infantile diarrhea: 1, physical factors: primary disease occurs mainly in infant, its endogenous cause of ill feature: (1) baby's gastrointestinal development is not mature enough, and the activity of enzyme is relatively low, but nutritional need is relatively many, gastrointestinal tract burden weight. (2) cradle nerve, endocrine, blood circulation and Liver and kidney function grow equal immaturity, and regulative mechanism is poor. (3) infant immunization function also imperfection. Serum escherichia coli antibody titer is minimum to 2 one full year of life to come into being, and edge up height later. Thus infant is susceptible to suffer from escherichia coli enteritis. In breast milk, escherichia coli antibody titer is high, and particularly just Ruzhong Escherichia coli secretory IgA is high, so the less morbidity of breast feeding infant, ill also lighter. In like manner young infant rotavirus antibody is low, and when same collective is popular, young infant is fallen ill many. (4) baby's body fluid compartments is different with adult, and extracellular fluid accounting example is higher, and water metabolism is vigorous, and regulatory function is poor again, is easier to body fluid, electrolyte disturbance. Baby is susceptible to suffer from rickets and malnutrition, easily causes digestive functional disturbance, and now intestinal secretion type IgA is not enough, easy what delay after diarrhoea. 2, infective agent: be divided in digestive tract and infection outside digestive tract, based on the former. (1) infect in digestive tract: pathogenic microorganism can enter digestant for baby road with the food polluted or water, thus easily occurs artificial feeding infant. When feeding, vessel used or food itself such as non-sterile or sterilization not, also have infection to be likely to. Virus infects also by respiratory tract or water source. The infection of (poison) person next to that carried disease germs by adult, is contaminted as broken out bacillary (or viral) enteritis rear section medical personnel in ward, becomes asymptomatic intestinal and carries disease germs (poison) person, may result in transmission of pathogen. (2) infect outside digestive tract: organ, tissue outside digestive tract are infected and also can cause diarrhoea, are common in otitis media, pharyngitis, pneumonia, urinary tract infection and skin infection etc.Diarrhoea is how not serious, and the age, more little person was more common. Cause the reason of diarrhoea partly because extra intestinal infection causes digestive functional disturbance, another part to be probably inside and outside intestinal to be caused by same cause of disease (mainly virus) sense. (3) enteric flora disturbance caused by abuse of antibiotics: long-term apply broad ectrum antibiotic relatively largely, such as chloromycetin, kanamycin, gentamycin, ampicillin, various cephamycin, particularly two kinds or the above and used time, except can directly stimulate intestinal or stimulate vegetative nerve to cause enterokinesia to speed, glucose absorption reduces, disaccharidase activity reduces and except suffering from diarrhoea, more seriously can cause enteric flora disturbance. Now normal intestinal escherichia coli disappear or significantly reduce, simultaneously drug-resistant S. aureus, Bacillus proteus, bacillus pyocyaneus, clostridium difficile or Candida albicans etc. can amount reproduction, cause medicine enteritis more rambunctious. 3, digestive functional disturbance: (1) dietary factor. (2) carbohydrate is not tolerated. (3) food anaphylaxis. (4) drug influence. (5) other factors: the changing suddenly of as very few in uncleanly environment, outdoor activities, rule of life, outside climatic sudden change (traditional Chinese medical science is called " wind, cold, summer-heat, dairrhea caused by pathogenic damp ") etc. also easily cause infantile diarrhea.
Analyzing the cause of disease of infantile diarrhea, therefore distinguish that its clinical syndrome is divided into: type of getting ill from overeating: performance abdominal distention, stomachache, cry noisy before rushing down, stool acid is smelly with indigestion milk block, and appetite is bad, has halitosis. It is more common in rotavirus enteritis with dyspepsia infant. Damp-heat type: performance stool, in egg soup sample, has a small amount of mucus, with heating, xerostomia, urinates deep yellow and lack. This kind of suffers from diarrhoea more common in the fall. Spleen-deficient intestinal infection is modal a kind of type in intestinal infection. It is mainly in the friendship in autumn in summer, the outer gas cut by epidemic disease caused by damp-heat pathogen poison and the intestines and stomach, strongly fragrant hold back in middle Jiao, retention and fumigation of damp-heat inside the body, QI and blood retardance, QI and blood and epidemic disease caused by damp-heat pathogen poison knot of fighting mutually turns to pus and blood; The development of evil in febrile disease is not normal and has loose bowels; Intestinal has heat then rush down lower urgently; Damp-heat gluing each other is then let out and not well; Damp invasion of lower energizer is burning sensation of the anus then; Damp and hot interior Sheng then dysphoria with smothery sensation is thirsty, oliguria with reddish urine; Red tongue, yellow and greasy fur, arteries and veins along several then all power damp and hot as. The acute stage of disease, is more common in spleen-deficient intestinal infection. Spleen-deficient: diarrhoea does not heal, soft stools, with white milk block, loss of appetite, becomes thin weak. Common rotavirus enteritis later stage or chronic diarrhea unhealed. Wind-cold type: diarrhoea has soft stools such as cystose, and color is light, and stink is few, suffers from abdominal pain with borborygmus. It is more common in the early stage of rotavirus enteritis.
The active stage state of an illness is critical or the peak period of disease progression, and hyperpyrexia, symptom increases the weight of gradually. Antibiotics alone therapeutic effect is inconspicuous, belongs to spleen-deficient intestinal infection by Chinese medical discrimination, then available herbal drug enema in treatment, can obtain good therapeutic effect.
The inspection of infantile diarrhea: blood routine examination. Stool microscopy: dyspepsia person has fat drop or a small amount of mucus, and enteritis person has leukocyte and accidental erythrocyte and phagocyte, the visible fungus of fungal enteritis to embrace son and mycelia, cultivates and may separate out pathogenic bacterium.
The Therapeutic Method of infantile diarrhea is as follows: 1, dietetic therapy: mild reduces milk amount, and generation is with rice water, sugar-salt-water etc.; Serious symptom answers fasting 8～24 hours, and vein fluid infusion. 2, fluid therapy: (1) oral medication: suitable in mild dehydration or vomit not severe one. (2) vein Clysis: for moderate, severe dehydration.3, control to infect for the cause of disease, select antibacterials. 4, symptomatic treatment: suffer from diarrhoea orally available bismuth subcarbonate or light acid albumin. Aid digestion orally available Pepsin Mixture, or polyzyme tablets.
But above-mentioned Therapeutic Method affects appetite, cures the symptoms, not the disease, it is unfavorable for treating, and toxic side effect.
Summary of the invention
The technical problem to be solved is in that; a kind of pharmaceutical composition treating infant spleen-deficient diarrhoea and preparation method thereof is provided; the present invention have regulate the flow of vital energy and in, spleen reinforcing stomach invigorating, loosening bowel to relieve constipation and clearing away heat-damp and promoting diuresis effect; have protection gastrointestinal mucosa concurrently, increase appetite, build up resistance and the effect of pain relieving; have rapid-action, effective percentage is high, determined curative effect, treatment short treating period, have no side effect, the advantages such as price is low.
In order to solve above-mentioned technical problem, the present invention provides a kind of pharmaceutical composition treating infant spleen-deficient diarrhoea, wherein, including following raw medicinal material: Herba Urariae crinitae, Moschus, Sargassum, Serissa foetida, Radix Rumicis Patientiae, Herba silenes fortunei, Bulbus Lilii, Rhizoma Curcumae, Flos Farfarae, Semen Cassiae, Aleuritopteris argentea (Gmel.) Fee, Herba Christiae Obcordatae, Flos Plumeriae Acutifoliae, Ganoderma, Flos Magnoliae Officinalis, Lasiosphaera Seu Calvatia, Partition in Fructus Juglandis, Caulis Tinosporae, halberd Ye Wawei, Bulbus Allii, Rhizoma Dioscoreae, Radix Et Caulis Acanthopanacis Senticosi, Semen Pittospori Glabrati, Herba Boschniakiae Rossicae, Climbing Viloet Herb and Pueraria lobota.
In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Herba Urariae crinitae 7-14 weight portion, Moschus 10-20 weight portion, Sargassum 6-12 weight portion, Serissa foetida 11-21 weight portion, Radix Rumicis Patientiae 14-28 weight portion, Herba silenes fortunei 8-19 weight portion, Bulbus Lilii 10-30 weight portion, Rhizoma Curcumae 9-18 weight portion, Flos Farfarae 12-32 weight portion, Semen Cassiae 12-21 weight portion, Aleuritopteris argentea (Gmel.) Fee 10-30 weight portion, Herba Christiae Obcordatae 8-16 weight portion, Flos Plumeriae Acutifoliae 12-32 weight portion, Ganoderma 13-23 weight portion, Flos Magnoliae Officinalis 13-31 weight portion, Lasiosphaera Seu Calvatia 11-21 weight portion, Partition in Fructus Juglandis 14-28 weight portion, Caulis Tinosporae 12-22 weight portion, halberd Ye Wawei 13-36 weight portion, Bulbus Allii 10-20 weight portion, 8-16 weight portion, Rhizoma Dioscoreae 10-30 weight portion, Radix Et Caulis Acanthopanacis Senticosi 7-14 weight portion, Semen Pittospori Glabrati 11-21 weight portion, Herba Boschniakiae Rossicae 12-32 weight portion, Climbing Viloet Herb 10-20 weight portion and Pueraria lobota 12-28 weight portion.
In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Herba Urariae crinitae 8-13 weight portion, Moschus 12-20 weight portion, Sargassum 7-12 weight portion, Serissa foetida 12-20 weight portion, Radix Rumicis Patientiae 15-28 weight portion, Herba silenes fortunei 9-18 weight portion, Bulbus Lilii 12-30 weight portion, Rhizoma Curcumae 10-16 weight portion, Flos Farfarae 14-30 weight portion, Semen Cassiae 12-20 weight portion, Aleuritopteris argentea (Gmel.) Fee 15-30 weight portion, Herba Christiae Obcordatae 8-15 weight portion, Flos Plumeriae Acutifoliae 12-30 weight portion, Ganoderma 14-22 weight portion, Flos Magnoliae Officinalis 15-30 weight portion, Lasiosphaera Seu Calvatia 12-20 weight portion, Partition in Fructus Juglandis 15-28 weight portion, Caulis Tinosporae 14-20 weight portion, halberd Ye Wawei 15-35 weight portion, Bulbus Allii 10-20 weight portion, 9-15 weight portion, Rhizoma Dioscoreae 10-30 weight portion, Radix Et Caulis Acanthopanacis Senticosi 7-12 weight portion, Semen Pittospori Glabrati 12-20 weight portion, Herba Boschniakiae Rossicae 14-30 weight portion, Climbing Viloet Herb 15-20 weight portion and Pueraria lobota 13-26 weight portion.
In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Herba Urariae crinitae 12 weight portion, Moschus 20 weight portion, Sargassum 9 weight portion, Serissa foetida 16 weight portion, Radix Rumicis Patientiae 24 weight portion, Herba silenes fortunei 15 weight portion, Bulbus Lilii 25 weight portion, Rhizoma Curcumae 15 weight portion, Flos Farfarae 30 weight portion, Semen Cassiae 16 weight portion, Aleuritopteris argentea (Gmel.) Fee 20 weight portion, Herba Christiae Obcordatae 13 weight portion, Flos Plumeriae Acutifoliae 24 weight portion, Ganoderma 15 weight portion, Flos Magnoliae Officinalis 28 weight portion, Lasiosphaera Seu Calvatia 15 weight portion, Partition in Fructus Juglandis 26 weight portion, Caulis Tinosporae 18 weight portion, halberd Ye Wawei 32 weight portion, Bulbus Allii 15 weight portion, 13 weight portions, Rhizoma Dioscoreae 20 weight portion, Radix Et Caulis Acanthopanacis Senticosi 11 weight portion, Semen Pittospori Glabrati 16 weight portion, Herba Boschniakiae Rossicae 25 weight portion, Climbing Viloet Herb 15 weight portion and Pueraria lobota 23 weight portion.
In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Herba Urariae crinitae 12 weight portion, Moschus 16 weight portion, Sargassum 9 weight portion, Serissa foetida 18 weight portion, Radix Rumicis Patientiae 24 weight portion, Herba silenes fortunei 15 weight portion, Bulbus Lilii 25 weight portion, Rhizoma Curcumae 15 weight portion, Flos Farfarae 30 weight portion, Semen Cassiae 18 weight portion, Aleuritopteris argentea (Gmel.) Fee 20 weight portion, Herba Christiae Obcordatae 12 weight portion, Flos Plumeriae Acutifoliae 30 weight portion, Ganoderma 21 weight portion, Flos Magnoliae Officinalis 18 weight portion, Lasiosphaera Seu Calvatia 14 weight portion, Partition in Fructus Juglandis 24 weight portion, Caulis Tinosporae 15 weight portion, halberd Ye Wawei 32 weight portion, Bulbus Allii 12 weight portion, 9 weight portions, Rhizoma Dioscoreae 20 weight portion, Radix Et Caulis Acanthopanacis Senticosi 9 weight portion, Semen Pittospori Glabrati 17 weight portion, Herba Boschniakiae Rossicae 25 weight portion, Climbing Viloet Herb 19 weight portion and Pueraria lobota 13 weight portion.
Described pharmaceutical composition also includes: Corm Eleocharitis, Fructus Papaveris nudicaulis, Folium Vaccinii Bracteati, fructus hippophae and Radix Notoginseng.
In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Herba Urariae crinitae 7-14 weight portion, Moschus 10-20 weight portion, Sargassum 6-12 weight portion, Serissa foetida 11-21 weight portion, Radix Rumicis Patientiae 14-28 weight portion, Herba silenes fortunei 8-19 weight portion, Bulbus Lilii 10-30 weight portion, Rhizoma Curcumae 9-18 weight portion, Flos Farfarae 12-32 weight portion, Semen Cassiae 12-21 weight portion, Aleuritopteris argentea (Gmel.) Fee 10-30 weight portion, Herba Christiae Obcordatae 8-16 weight portion, Flos Plumeriae Acutifoliae 12-32 weight portion, Ganoderma 13-23 weight portion, Flos Magnoliae Officinalis 13-31 weight portion, Lasiosphaera Seu Calvatia 11-21 weight portion, Partition in Fructus Juglandis 14-28 weight portion, Caulis Tinosporae 12-22 weight portion, halberd Ye Wawei 13-36 weight portion, Bulbus Allii 10-20 weight portion, 8-16 weight portion, Rhizoma Dioscoreae 10-30 weight portion, Radix Et Caulis Acanthopanacis Senticosi 7-14 weight portion, Semen Pittospori Glabrati 11-21 weight portion, Herba Boschniakiae Rossicae 12-32 weight portion, Climbing Viloet Herb 10-20 weight portion, Pueraria lobota 12-28 weight portion, Corm Eleocharitis 10-20 weight portion, Fructus Papaveris nudicaulis 2-4 weight portion, Folium Vaccinii Bracteati 14-32 weight portion, fructus hippophae 15-25 weight portion and Radix Notoginseng 10-20 weight portion.
In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Herba Urariae crinitae 12 weight portion, Moschus 16 weight portion, Sargassum 9 weight portion, Serissa foetida 18 weight portion, Radix Rumicis Patientiae 24 weight portion, Herba silenes fortunei 15 weight portion, Bulbus Lilii 25 weight portion, Rhizoma Curcumae 15 weight portion, Flos Farfarae 30 weight portion, Semen Cassiae 18 weight portion, Aleuritopteris argentea (Gmel.) Fee 20 weight portion, Herba Christiae Obcordatae 12 weight portion, Flos Plumeriae Acutifoliae 30 weight portion, Ganoderma 21 weight portion, Flos Magnoliae Officinalis 18 weight portion, Lasiosphaera Seu Calvatia 14 weight portion, Partition in Fructus Juglandis 24 weight portion, Caulis Tinosporae 15 weight portion, halberd Ye Wawei 32 weight portion, Bulbus Allii 12 weight portion, 9 weight portions, Rhizoma Dioscoreae 20 weight portion, Radix Et Caulis Acanthopanacis Senticosi 9 weight portion, Semen Pittospori Glabrati 17 weight portion, Herba Boschniakiae Rossicae 25 weight portion, Climbing Viloet Herb 19 weight portion, Pueraria lobota 13 weight portion, Corm Eleocharitis 20 weight portion, Fructus Papaveris nudicaulis 3 weight portion, Folium Vaccinii Bracteati 32 weight portion, fructus hippophae 24 weight portion and Radix Notoginseng 14 weight portion.
When the dosage form of described pharmaceutical composition is granule, its preparation method comprises the following steps:
The first step, each for described pharmaceutical composition raw medicinal material is mixed in described ratio, add the ethanol that determining alcohol is 85%～95% relative to 4～8 times of mixture, heat to boiling reflux 3～5 hours, filter, adopt percolation with the speed slowly percolation of 1～2ml per minute, collect percolate, being evaporated to relative density when 50～60 DEG C subsequently under vacuum 0.06～0.09Mpa is the mastic of 1.04～1.10, spray drying, the inlet temperature of spray dryer 160～175 DEG C, leaving air temp 80～85 DEG C, be ground into powder subsequently, make dried cream powder;
Second step, adds the dextrin of the cane sugar powder relative to dried cream powder quality 0.2～0.4 times and 0.1～0.2 times in the dried cream powder obtained, makes granule, dries in 40～50 DEG C, it is thus achieved that granule.
When the dosage form of described pharmaceutical composition is syrup, its preparation method comprises the following steps:
The first step, Radix Rumicis Patientiae, Herba silenes fortunei, Bulbus Lilii and Rhizoma Curcumae are mixed in described ratio, add the ethanol that determining alcohol is 80%～90% relative to 4～6 times of mixture, heating and refluxing extraction 2～4 times, each reflux, extract, 2 hours～3 hours, united extraction liquid, with the centrifugal remove impurity of tube centrifuge, when extracting solution after remove impurity is evaporated to 60 DEG C in 60 DEG C～70 DEG C when, relative density is the medicinal liquid of 1.05～1.10, concentrated solution spray dryer after concentration is dried, it is ground into 100～200 orders subsequently, it is thus achieved that dry powder;
Second step, Semen Pittospori Glabrati, Herba Boschniakiae Rossicae, Climbing Viloet Herb and Pueraria lobota are mixed in described ratio, is ground into powder, with the ethanol that determining alcohol is 85%～95% as solvent, impregnate 48 hours～72 hours, adopting percolation with the speed slowly percolation of 1～2ml per minute, collect percolate, being concentrated into relative density when 60 DEG C is the mastic of 1.25～1.27, dry with spray dryer, being ground into 100～200 orders subsequently, it is thus achieved that dry powder, the quality of affiliated ethanol is 3～5 times of second step mixture quality;
3rd step, surplus stock medical material is mixed in described ratio, add relative to the alcohol reflux that mixture 4～6 times amount determining alcohol is 70%～80% 2～4 times, each 1 hour～3 hours, filtering respectively, each time filtrate merges, reclaim ethanol, being concentrated into relative density when 60 DEG C is the mastic of 1.20～1.22, dries in 55 DEG C～65 DEG C reduced vacuum, obtains dry powder;
4th step, the dry powder blend that the first step is obtained to the 3rd step, add the water dissolution relative to mixture quality 3～5 times, pH value is regulated to 7.0 with 40% sodium hydroxide solution, it is subsequently added powder mixture quality 30～60% sucrose, 0.1～0.3% potassium sorbate mix homogeneously that obtain relative to the first step to the 3rd step, obtains syrup.
When the dosage form of described pharmaceutical composition is injectable powder, its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, putting into the mixed powder that the micron particles being ground into 0.1～10 μm of volume average particle size in super micron mill and particle diameter form less than the nano-scale particle of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%;
Second step, the mixed powder that the first step obtains adds the ethanol that determining alcohol is 85%～95% of the quality 3～5 times relative to described mixed powder, stirring and dissolving obtains alcoholic solution, alcoholic solution is stood 24～36 hours when 5 DEG C～10 DEG C, adopt percolation with the speed slowly percolation of 1～2ml per minute, collect percolate, concentrate and dry, and pulverizing 40～60 minutes in super micron mill are put at this, the mixed powder that the micron particles of 0.1～10 μm of volume average particle size of acquisition and particle diameter form less than the nano-scale particle of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, takes mixed powder 10g～20g that second step obtains, and adds propylene glycol 30g～50g, adds 200ml water for injection, and stirring makes it dissolve, and injects water to 1000ml further, adds 1g～1.5g needle-use activated carbon, is sufficiently stirred for 30～50 minutes;Decarbonization filtering; With 0.22～0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.
The invention has the beneficial effects as follows: the present invention have regulate the flow of vital energy and in, spleen reinforcing stomach invigorating, loosening bowel to relieve constipation and clearing away heat-damp and promoting diuresis effect; have protection gastrointestinal mucosa concurrently, increase appetite, build up resistance and the effect of pain relieving; have rapid-action, effective percentage is high, determined curative effect, treatment short treating period, have no side effect, the advantages such as price is low.
Detailed description of the invention
The present invention with regulate the flow of vital energy and in, spleen reinforcing stomach invigorating, loosening bowel to relieve constipation and clearing away heat-damp and promoting diuresis be for primary treatment principle, treatment infant spleen-deficient diarrhoea, wherein, including following raw medicinal material: Herba Urariae crinitae, Moschus, Sargassum, Serissa foetida, Radix Rumicis Patientiae, Herba silenes fortunei, Bulbus Lilii, Rhizoma Curcumae, Flos Farfarae, Folium Vaccinii Bracteati, fructus hippophae, Semen Cassiae, Aleuritopteris argentea (Gmel.) Fee, Herba Christiae Obcordatae, Flos Plumeriae Acutifoliae, Ganoderma, Flos Magnoliae Officinalis, Radix Notoginseng, Lasiosphaera Seu Calvatia, Partition in Fructus Juglandis, Caulis Tinosporae, halberd Ye Wawei, Bulbus Allii, Rhizoma Dioscoreae, Corm Eleocharitis, Fructus Papaveris nudicaulis, Radix Et Caulis Acanthopanacis Senticosi, Semen Pittospori Glabrati, Herba Boschniakiae Rossicae, Climbing Viloet Herb and Pueraria lobota.
Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:
Pueraria lobota: another name: cut Gu Lianteng, Radix vitis romanetii, rattan of transplanting seedlings. Source: Vitaceae Pueraria lobota VitisflexuosaThunb., with root, stem, fruit medicine. Nature and flavor: sweet are flat. Cure mainly: tonifying five ZANG-organs, reuniting the fractured tendons and bones, longue meat, edible fruit. Joint is ached, traumatic injury: deposited affected part mashed by root bark sweet wine. Pueraria lobota Semen Pittospori Glabrati: source: " Traditional Chinese Medicine in Sichuan will ". Another name: fragrant plant bean, precipice beggar (" Chinese tree taxonomy "), squeezes wood core (" Traditional Chinese Medicine in Sichuan will "), Fructus Hyperici belli, wide Semen Pittospori Glabrati (" conventional Chinese herbal medicine formula "). Source: for the seed of Pittosporaceae plant Pittosporum glabratum Lindl.. Pluck fruit after autumn, dry, break up shell, take out kernel and dry again. Nature and flavor: " Traditional Chinese Medicine in Sichuan will ": " property is put down, and bitter and puckery flavor is nontoxic. " return through: " Traditional Chinese Medicine in Sichuan will ": " enters lung, spleen. Large intestine three warp. " cure mainly: heat clearing away, promoting the production of body fluid to quench thirst. Control deficiency-heat vexed, thirsty pharyngalgia, weight, fatigue and weakness after dysentery. " Traditional Chinese Medicine in Sichuan will ": " heat clearing away, antidiarrheal, convergence. Control pharyngalgia, weight, lassitude of the limbs and weakness after lower profit. "
Fructus Papaveris nudicaulis: source: " Ningxia Chinese herbal medicine handbook ". Another name: Herba Papaveris amurensis, mountain Semen Papaveris, hair Semen Papaveris, wild opium (" Jilin Chinese herbal medicine "), mountain Plantula Papaveris (" Chinese herbal medicine handbook is commonly used in northeast "). Source: for the fruit of bloodroot Fructus Papaveris nudicaulis, shell or wounded in the battle herb. Summer, autumn gather. Nature and flavor: 1. " Chinese herbal medicine handbook is commonly used in northeast ": " sour micro-bitterness. " 2. " Chinese Herbal Medicine in Xinjiang handbook ": " cold nature is poisonous. " curing mainly: 1. " blue or green woods Chinese herbal medicine ": " astringing intestine to stop diarrhea pain relieving, removing toxic substances. Control enteritis, dysentery. " 2. " Chinese herbal medicine handbook is commonly used in northeast ": " eases pain, cough-relieving, Dingchuan, antidiarrheal. Control nervous headache, migraine, chronic cough, pant, dysentery, have blood in stool, seminal emission, menstrual pain, leucorrhea, proctoptosis, acute or chronic gastritis, gastric ulcer, stomachache. "
Corm Eleocharitis: another name: Horse hoof, crow taro, Di Li, a kind of wild plant, the subteranean stem of which is like water chestnut, shepherd's purse, Herba Eleocharitis [Zhejiang Hangzhou]. Source: Cyperaceae Eleocharis plant Corm Eleocharitis Eleocharisdulcis(Burm.f.) Trin.exHenschel [E.tuberosaRoemetSchudt.; E.plantagineaR.Brown.], it is used as medicine with bulb and aerial parts. Autumn end extracts aerial parts, dries; Bulb can fresh adopt. Nature and flavor: bulb: sweet are flat. Herb on the ground: bitter is flat.
Curing mainly: bulb: relieve heat and thirst, dampness removing reduces phlegm, blood pressure lowering.For consumption of body fluid caused by febrile disease excessive thirst, laryngopharynx swelling and pain, stomatitis, jaundice due to damp-heat, hypertension, dysuria, measles, cough due to lung-heat, silicosis, bleeding hemorrhoids. Herb on the ground: clearing away heat and promoting diuresis. For singultus, dysuria.
Climbing Viloet Herb: another name: white Viola grypoceras A. Gray, Rhizoma Bergeniae scopulosae, wild Chinese cabbage, Herba Violae Serpentis, Fructus Trichosanthis Cucumeroidis grass, Fructus Cucumidis sativi grass, Matteuccia struthiopteri, Fructus Cucumidis sativi dish, silver teaspoon, stone Chinese cabbage, green snow. Source: Violaceae Viola plant Herba Violae Diffusae VioladiffusaGing., with all herbal medicine. Spring Mo or autumn end gather herb, dry. Nature and flavor: bitter, micro-pungent, cold. Cure mainly: heat-clearing and toxic substances removing, detumescence and apocenosis. For hepatitis, pertussis, conjunctival congestion and swelling pain; Acute mastitis, furuncle, carbuncle furuncle, herpes zoster, venom, traumatic injury are controlled in external.
: another name: Canis familiaris L. Pericarpium Zanthoxyli, Radix Zanthoxyli Avicennae [Fujian, Guangdong], chicken Hu, seed of Zanthoxylum armatum DC.(Z.Planispinum Sieb.et Zucc.) [Hainan], Zanthoxylum avicennae, Ramulus Kalopanacis seu Araliae [Guangdong, Guangxi]. Source: Rutaceae xanthoxylum Zanthoxylumavicennae(Lam.) DC., is used as medicine with root, leaf and fruit. Root can be adopted the whole year; Leaf can be adopted at any time; Fruit is adopted winter, dries. Nature and flavor: bitter, pungent, tepor. Cure mainly: expelling wind and removing dampness, promoting blood circulation and stopping pain. Root: icterohepatitis, oedema due to nephritis, rheumatic arthritis. Really: stomachache, stomachache. Leaf: traumatic injury, lumbar muscle strain, mastitis, furuncle and phyma.
Halberd Ye Wawei: source: fern Polypodiaceae halberd Ye Wawei Lepisoruswaltonii(Ching) Ching, is used as medicine with spore. Nature and flavor: bitter, sweet, flat. Cure mainly: relieving stranguria by diuresis, eliminating heat from the lung. Cure mainly oedema due to nephritis, urinary tract infection, calculus of urethra, cough due to lung-heat, spitting of blood, bronchial asthma, the disease such as pharyngolaryngitis.
Partition in Fructus Juglandis: another name: Semen Juglandis kind every. Source: this product is the wooden barrier film of juglandaceae plant Semen Juglandis JuglansregiaL.. Nature and flavor: bitter, puckery are flat. Cure mainly: kidney arresting seminal emission. For emission due to deficiency of the kidney, spermatorrhea, the enuresis.
Flos Plumeriae Acutifoliae: another name: remote Fructus Gardeniae. Source: for Apocynaceae Flos Plumeriae Acutifoliae platymiscium Flos Plumeriae Acutifoliae PlumeriarubraL.cv.Acutifolia [P.rubraL.var.acutifolia(Poir.) Bailey; P.acuminataAit.], it is used as medicine with flower. Summer picks flowers, and dries. Nature and flavor: sweet are cool. Cure mainly: heat-clearing and toxic substances removing, dampness removing, cough-relieving. For preventing heatstroke, enteritis, bacillary dysentery, dyspepsia, infantile malnutrition, infectious hepatitis, bronchitis.
Semen Cassiae: another name: Horse hoof Semen Cassiae, blunt leaf Semen Cassiae, false Semen phaseoli radiati, Semen Cassiae. Source: this product is leguminous plant Semen Cassiae CassiaobtusifoliaL. or the dry mature seed of little Semen Cassiae CassiatoraL.. Gather autumn mature fruit, dry, lay seed, remove impurity. Nature and flavor: sweet, bitter, salty, are slightly cold. Gui Jing: return liver, large intestine channel. Cure mainly: clearing away heat to improve acuity of vision, loosening bowel to relieve constipation. For the puckery pain of conjunctival congestion, the many tear of photophobia, dizziness of having a headache, poor vision, constipation.
Folium Vaccinii Bracteati: source: " book on Chinese herbal medicine is newly organized ". Another name: Vaccinium bracteatum Thunb. branch and leaf (" Kaibao Bencao "). Source: for the leaf of ericad Fructus Vaccinii Bracteati. 8～JIUYUE is gathered, and picks clean sprig and impurity, dries. The dry place of storage. Nature and flavor: sour and astringent are flat. 1. " Kaibao Bencao ": " bitter, flat, nontoxic. " 2. " detailed outline ": " is sour and astringent. " return through: " Bencao Jingshu ": " enters the heart, spleen, kidney three warp. " cure mainly: benefit vital essence, bone and muscle strengthening, improving eyesight, stopping leak. 1. supplement to the Herbal: " stopping leak removes and sleeps, strong muscle physical strength profiting." 2. " Japan hanako materia medica ": " benefit the intestines and stomach, smashes juice leaching and steams, dry clothes. " 3. " book on Chinese herbal medicine converges and says ": " QI invigorating adds essence, removing heat from blood nourishing muscle and tendon. "
Radix Notoginseng: source: this product is panax araliaceae plant Panaxnotoginseng(Burk.) dry root of F.H.Chen. Autumn excavates before the flowers are in blossom, cleans, separately main root, supporting root and stem foot, dry. Supporting root is practised and is claimed " rib ", and stem foot is practised and claimed " clip ". Nature and flavor: hardship sweet, micro-, temperature. Gui Jing: return liver, stomach warp. Cure mainly: dissipating blood stasis stops blooding, subduing swelling and relieving pain. For spitting blood, spit blood, epistaxis, to have blood in stool, metrorrhagia, traumatic hemorrhage, chest and abdomen twinge, tumbling and swelling.
Bulbus Lilii: another name: Herba Crotalariae sessiliflorae, cone, BULBUS LILII, medicine Bulbus Lilii, family Bulbus Lilii. Source: this product is the dry meat scale leaf of liliaceous plant tiger lily LiliumlancifoliumThunb., Bulbus Lilii LiliumbrowniiF.E.Brownvar.viridulumBaker or Lilium tenuifolium LiliumpumilumDC.. Autumn excavates, and cleans, strips scale leaf, put in boiling water slightly boiling hot, dry. Nature and flavor: sweet, cold. Gui Jing: GUIXIN, lung meridian.
Cure mainly: nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization. For deficiency of YIN chronic cough, sputum mixed with blood, fidgets due to deficiency is palpitated with fear, insomnia and dreamful sleep, absentminded.
Radix Rumicis Patientiae: source: for the general designation of Polygonaceae Rumex various plants. Except curled dock, Radix Rumicis Japonici and rumex dentatus, Rumex patientia Linn. RumexpatientiaL., Rumex chalepensis R.chalepensisMill. and narrow leaf Radix rumicis acetosae R.stenophyllusLedeb. is still had all to be used as medicine with root. Spring, autumn uproot, and remove stem and leaf, clean, and section is dried standby. Nature and flavor: bitter, sour, cold. Cure mainly: cooling blood for hemostasis, heat-clearing and toxic substances removing, parasite killing. For dysfunctional uterine hemorrhage, spit blood, spitting of blood, epistaxis, gingival hemorrhage, tail, duodenal hemorrhage, have blood in stool, purpura, constipation, edema; Scabies, furuncle, seborrheic dermatitis are controlled in external.
Ganoderma: another name: Ganoderma lucidum seu Japonicum, Ganoderma, Ganoderma Lucidum. Source: this product is On Polyporaceae Ganoderma lucidum (Leyss. Ex Fr.) Karst. Ganodermalucidum(Leyss.exFr.) the dry sporophore of Karst. or Ganoderma GanodermasinenseZhao, XuetZhang. The whole year gathers, and removes impurity, wipes out the lower end stem with rotten wood, silt or culture matrix, dry in the shade or 40～50 DEG C of drying. Nature and flavor: sweet are flat. Gui Jing: GUIXIN, lung, liver, kidney channel. Cure mainly: invigorating QI and tranquilization, relieving cough and asthma. For dizziness sleeplessness, shortness of breath and palpitation, asthenia cough with asthma.
Moschus: another name: former Moschus, fragrant umbilicus, young grass, Moschus moschiferous umbilicus fragrant, smelly. Source: this product is the dry secretions in animal in deer family woods Moschus moschiferous MoschusberezovskiiFlerov, horse Moschus moschiferous MoschussifanicusPrzewalski or former Moschus moschiferous MoschusmoschiferusLinnaeus maturation hero body note capsule. Wild Moschus moschiferous is many, and extremely time spring hunts in the winter time, after trapping, extracts sachet, dries in the shade, practises and claim " hair shell Moschus "; Cut sachet open, remove softgel shell, practise and claim " Moschus core ". Family Moschus moschiferous directly takes out Moschus core from its sachet, dries in the shade or uses exsiccator close drying. Nature and flavor: pungent, temperature. Gui Jing: GUIXIN, spleen channel. Cure mainly: refreshment of having one's ideas straightened out, promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain. For calentura coma, apoplexy syncope due to accumulation of phlegm, stagnation of QI sudden syncope, attacked by pestiferous factors is gone into a coma, amenorrhea, abdominal mass, stillborn fetus of having difficult labour, trusted subordinate's sudden pain, carbuncle scrofula, and laryngopharynx swelling and pain falls and flutters the pain of injury, and arthralgia pain is numb.
Rhizoma Curcumae: another name: Curcuma wenyujin, Rhizoma Curcumae, radix zedoariae, Rhizoma Trillii Tschonoskii, smelly dung Rhizoma Zingiberis Recens.Source: this product is the dry rhizome of zingiberaceous plant Rhizoma Curcumae CurcumaphaeocaulisVal., Guangxi zedoary CurcumaKwangsiensisS.G.LeeetC.F.Liang or RADIX CURCUMAE CurcumawenyujinY.H.ChenetC.Ling. The latter practises title " Curcuma wenyujin ". Winter, stem and leaf was excavated after withering, and cleans, steams or boil to the saturating heart, dries or removes fibrous root and impurity after cold drying. Nature and flavor: pungent, bitter, temperature. Gui Jing: return liver, spleen channel. Cure mainly: circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving. For abdominal mass mass in the abdomen, blood stasis amenorrhea, food stagnation distending pain; Early cervical carcinoma.
Aleuritopteris argentea (Gmel.) Fee: source: " Shanxi Chinese medicinal herbal ". Another name: Herba Melicae Scabrosae (" Shanxi Chinese medicinal herbal "), spasmolytic grass, gold thread copper sheet, gagger grass (" Zhejiang natural resources of Chinese medicinal materials register "), HERBA ALEURITOPTERIS, child's fist, Herba Lycopodii (" Henan Chinese herbal medicine handbook "). Source: for the Herb of Sinopteridaceae plant Aleuritopteris argentea (Gmel.) Fee. Autumn collects, and dries.
Nature and flavor: " Henan Chinese herbal medicine handbook ": " property is put down, lightly seasoned; Leaf: bitter in the mouth. " cure mainly: cough-relieving, regulating menstruation, damp eliminating. Control cough, menoxenia, leucorrhea with red and white discharge. 1. " Shanxi Chinese medicinal herbal ": " promoting blood circulation to restore menstrual flow. " 2. " Zhejiang natural resources of Chinese medicinal materials register ": " is controlled the frightened contraction of children's and is twitched. " 3. " register planted by Guangxi medicine ": " cough-relieving, controls gynaecological disease, " 4. " Henan Chinese herbal medicine handbook ": " promoting blood flow to regulate menstruation, damp eliminating, cold expelling, pain relieving. "
Radix Et Caulis Acanthopanacis Senticosi: source: this product is dry, root and rhizome or the stem of stems and leaves of acanthopanax senticosus (Rupr.etMaxim.) Harms. Spring, season in autumn two gather, cleaning, drying. Nature and flavor: hardship pungent, micro-, temperature. Gui Jing: return spleen, kidney, heart channel. Cure mainly: replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization. For deficiency of spleen-YANG and kidneyYANG, body void is weak, inappetence, soreness of waist and knee joint, insomnia and dreamful sleep.
Flos Farfarae: another name: Flos Farfarae. Source: this product is the dry flower of feverfew coltsfoot TussilagofarfaraL.. Excavate when flower is not yet unearthed before December or frozen ground, remove bennet and silt, dry in the shade. Nature and flavor: hardship pungent, micro-, temperature. Gui Jing: return lung meridian. Cure mainly: nourishing the lung to keep the adverse QI downward, relieving cough and resolving phlegm. Cough for new chronic cough, dyspnea and cough with excessive sputum, chronic cough hemoptysis.
Sargassum: source: this product is Sargassaceae plant Sargassum Sargassumpallidum(Turn.) C.Ag. or Sargassum fusiforme (Harv.) Setch Sargassumfusiforme(Harv.) the dry frond of Setch.. The former practises title " compatibile ", and the latter practises title " lobule Sargassum ". Summer, season in autumn two fish, and remove impurity, clean, dry. Nature and flavor: bitter, salty, cold. Gui Jing: return liver, stomach, kidney channel. Cure mainly: hard masses softening and resolving, expectorant, diuretic. For goiter, scrofula, painful and swollen testis, phlegm retention edema.
Lasiosphaera Seu Calvatia: another name: ash bag, horsehit bag. Source: for Hui Bao section lasiosphaera fenzlii Reics platymiscium lasiosphaera fenzlii Reics LasiosphaerafenzliiReich., Lycoperdon plant calvatia gigantea Calvatiagigantea(Batach.exPers.) the nearly mature sporophore of Lloyd. and purple Lasiosphaera Seu Calvatia C.lilacinaLloyd.. Gather during sporophore just maturation in autumn, remove silt, dry. Nature and flavor: pungent are flat. Cure mainly: heat clearing away, sore-throat relieving, hemostasis. Cure mainly: pharyngolaryngitis, tonsillitis; Traumatic hemorrhage, bleeding hemorrhoids chilblain are controlled in external.
Bulbus Allii: another name: Bulbus Allii, Bulbus Allii. Source: be used as medicine with bulb for Liliaceae allium Bulbus Allii AlliumsativumL.. Spring, summer gather, binding, hang ventilation, dry in the shade standby.Nature and flavor: pungent, temperature. Cure mainly: stomach invigorating, dysentery relieving, cough-relieving, sterilization, anthelmintic. Prevention influenza, epidemic cerebrospinal meningitis. Control pulmonary tuberculosis, pertussis, inappetence, dyspepsia, bacillary dysentery, amebic dysentery, enteritis, enterobiasis, ancylostomiasis; Trichomonas vaginitis, acute appendicitis are controlled in external.
Serissa foetida: another name: Radix Serissae, Caulis et folium pavettae hongkongensis [Jiangsu, Guangdong], Rhizoma Hedychii Coronarii, TianXing wood, roadside chaste tree, Os Gallus domesticus bavin. Source: for Rubiaceae Serissa foetida platymiscium Serissa foetida Serissaserissoides(DC.) Druce, is used as medicine with Herb. The whole year can adopt. Clean using fresh herb or cutting is dried. Nature and flavor: light, micro-pungent are cool. Cure mainly: dispelling wind to relieve the exterior syndrome, clearing away heat-damp and promoting diuresis, relaxing muscles and tendons and activating QI and blood in the collateral. For catching a cold, cough, toothache, acute tonsillitis, pharyngolaryngitis, acute hepatitis, chronic hepatitis, enteritis, dysentery, infantile malnutrition, hypertension complicated headache, migraine, rheumatic arthralgia, leucorrhea; Stem ashing eye dripping controls mist.
Herba Christiae Obcordatae: another name: butterfly leaf, sieve grass, Herba Dichodrae, Desmodiumtrilorumrr., money cutter grass, Herba Asari [Fujian]. Source: pulse family Vespertilio grass platymiscium floor file Vespertilio grass Christiaobcordata(Poir.) Bahn.f. [LoureaobcordataDesv.], is used as medicine with herb or root. Xia Qiu gathers, and cleans, using fresh herb or dry. Nature and flavor: micro-hardship are cool. Cure mainly: herb: clearing away heat-damp and promoting diuresis, diuresis leukorrhagia stopping. For conjunctivitis, dysuria, cystitis, urethritis, chronic nephritis, mastitis, stranguria caused by urinary stone, leucorrhea; Scabies, traumatic injury, venom are controlled in external. Root: removing heat from blood. For spitting blood, hemoptysis.
Herba silenes fortunei: source: " Jiangsu medical material will ". Another name: wild palmate meadowsweet (" southern Jiangsu seed plant "), CANGYINGHUA (" Chinese medicinal herbal "), water-white ginseng, spend one bottle in vain, lobule Fel Cyprinus carpio, Herba Dianthi Radix Adenophorae (Radix Glehniae), August is white, spend Herba Dianthi, little purslane speedwell Herba, white calabash, Herba Lycopi (" Zhejiang conventional medical herbs among the people ") in vain. Source: for the whole herb with root of pinkwort fly grass. Nature and flavor: " Zhejiang conventional medical herbs among the people ": " pungent puckery, cool. " cure mainly: heat clearing away profit alunite, qi-restoratives is invigorated blood circulation. Controlling urinary tract infection, leucorrhea, dysentery, body is empty after being ill, turns round, dampens. 1. " Jiangsu medical material will ": " strengthening by means of tonics. Control that body is brave or weak few power after being ill. " 2. " Zhejiang conventional medical herbs among the people ": " clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling. "
Caulis Tinosporae: source: " Nanning City's medicine will ". Another name: Herba Lycopodii, the raw palpus (" Guangxi Chinese veterinarian's medicine is planted ") in nothing ground, blue or green Herba Lycopodii (" Luchuan is herbal "), cut dead (" Nanning City's medicine will "), relaxing muscles and tendons rattan (Guangzhou army " conventional Chinese herbal medicine handbook "). Source: for the stem of menispermaceous plants Tinospora sinensis. The whole year can adopt. Nature and flavor: " Nanning City's medicine will ": " bitter, cold. " curing mainly: 1. " Nanning City's medicine will ": " relaxing muscles and tendons and activating QI and blood in the collateral, parasite killing. External application traumatic injury tendon breaking, rheumatic ostalgia; Relaxing muscles and tendons and activating QI and blood in the collateral for oral administration. " 2. Guangzhou army " conventional Chinese herbal medicine handbook ": " relaxing muscles and tendons and activating QI and blood in the collateral, clearing away heat-damp and promoting diuresis. Dispelling the wind and dampness pathogens bones and muscles pain, lumbar muscle strain, traumatic injury. "
Herba Boschniakiae Rossicae: another name: Herba Cistanches. Source: Orobanchaceae Boschniakia plant plait Herba Cistanches Boschniakiarossica(Cham.etSchlecht.) B.Fedtsch.etFlerov [B.glabraC.A.Mey.], with all herbal medicine. Spring excavates, and dries cutting. Nature and flavor: sweet, salty, temperature. Cure mainly: kidney invigorating and YANG supporting, loosening bowel to relieve constipation. For impotence due to deficiency of the kidney, chills and pain of the waist and kness, dryness of the intestine constipation.
Rhizoma Dioscoreae: another name: Rhizoma Dioscoreae, soil potato, mountain Rhizoma Dioscoreae, RHIIZOMA DIOSCOREAE fr0m Henan of China, Rhizomadioscoreae, white Rhizoma Dioscoreae.Source: this product is the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae DioscoreaoppositaThunb.. Winter, stem and leaf was excavated after withering, and cut root head, cleaned, and removed crust and fibrous root, after smoking with sulfur, dry; Also have and select loose straight dry Rhizoma Dioscoreae, put in clear water, be dipped into without the dry heart, vexed, after smoking with sulfur, trim two ends, be twisted into plank cylindric, dry, polishing, practise and claim " light yam ". Note: congener dioscorea japonica DioscoreajaponicaThunb. is wild in China various places. Its root is also used as medicine as Rhizoma Dioscoreae, and effect is similar. Nature and flavor: sweet are flat. Gui Jing: return spleen, lung, kidney channel. Curing mainly: spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission. For insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, and deficiency-heat is quenched one's thirst. Rhizoma Dioscoreae (parched with bran) spleen reinforcing stomach invigorating. For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, leukorrhagia.
Fructus hippophae: source: " Chinese herbal medicine is commonly used in Tibet ". Another name: Fructus Elaeagni Angustifoliae (" plateau Chinese herbal treatment handbook "), big Er Buxing (Tibetan name). Source: for the fruit of Elaeangnaceae plant Fructus Hippophae. 10～November, harvesting ripe fruit, dried. Nature and flavor: " Chinese herbal medicine is commonly used in Tibet ": " warm in nature, sour-puckery flavor. " return through: " plateau Chinese herbal treatment handbook ": " enters liver, stomach, intestine and small intestine warp. " curing mainly: 1. " Chinese herbal medicine is commonly used in Tibet ": " promoting blood circulation to remove blood stasis, reduce phlegm the chest stuffiness relieving, spleen reinforcing stomach invigorating. Control traumatic injury, congestive edema, cough with copious phlegm, dyspnea, dyspepsia. " 2. " plateau Chinese herbal treatment handbook ": " promoting the production of body fluid to quench thirst, heat clearing away system is rushed down. Control high thermal burn YIN syndrome, bronchitis, enteritis, dysentery. "
Flos Magnoliae Officinalis: source: this product is Magnoliacea plant Cortex Magnoliae Officinalis MagnoliaofficinalisRehd.etWils. or the dry flower of magnolia officinalis rehd.et wils.var.biloba rehd.et wils. MagnoliaofficinalisRehd.etWils.Var.bilobaRehd.etWils.. Harvesting when spring, flower was open, after slightly steaming, dries or cold drying. Nature and flavor: bitter, tepor. Gui Jing: return spleen, stomach warp. Cure mainly: regulate the flow of vital energy, removing dampness. For the breast vexed distension of gastral cavity painful abdominal mass, poor appetite.
Herba Urariae crinitae: source: " the south of Fujian Province traditional herbal medicine ". Another name: Herba Urariae Lagopodioidis, timothy grass (" Guangxi Chinese medicinal herbal "), system sky grass (" the south of Fujian Province traditional herbal medicine "), university degree mountain cyanines, ancient coin window grass, ferrum gold mace (" Quanzhou book on Chinese herbal medicine "), Canis familiaris L. tail penetrates (" Fujian Chinese herbal medicine "). Source: the herb penetrated for leguminous plant cat tail. Autumn, receipts were adopted. Nature and flavor: " the south of Fujian Province traditional herbal medicine ": " sweet micro-hardship, flat. " cure mainly: heat clearing away, removing toxic substances, hemostasis, eliminating carbuncle. Control cough, lung abscess, spit blood, spitting of blood, hematuria, proctoptosis, uterine prolapse, toxic swelling. 1. " the south of Fujian Province traditional herbal medicine ": " moisturizing antipyretic, eliminating carbuncle detoxifies. " 2. " Guangxi Chinese herbal medicine ": " dissipating blood stasis stops blooding, clearing and antitussive. Controlling haematemesis, spitting of blood, hematuria, knife injury is hemorrhage, cough due to lung-heat, uterine prolapse, proctoptosis. " 3. LongXi " practical Chinese herbal medicine ": " promoting blood circulation to remove obstruction in the collateral, regulate the flow of vital energy and in. Control gastric and duodenal ulcers, pulmonary tuberculosis, leucorrhea, arthritis, infantile malnutrition. "
In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Herba Urariae crinitae 7-14 weight portion, Moschus 10-20 weight portion, Sargassum 6-12 weight portion, Serissa foetida 11-21 weight portion, Radix Rumicis Patientiae 14-28 weight portion, Herba silenes fortunei 8-19 weight portion, Bulbus Lilii 10-30 weight portion, Rhizoma Curcumae 9-18 weight portion, Flos Farfarae 12-32 weight portion, Semen Cassiae 12-21 weight portion, Aleuritopteris argentea (Gmel.) Fee 10-30 weight portion, Herba Christiae Obcordatae 8-16 weight portion, Flos Plumeriae Acutifoliae 12-32 weight portion, Ganoderma 13-23 weight portion, Flos Magnoliae Officinalis 13-31 weight portion, Lasiosphaera Seu Calvatia 11-21 weight portion, Partition in Fructus Juglandis 14-28 weight portion, Caulis Tinosporae 12-22 weight portion, halberd Ye Wawei 13-36 weight portion, Bulbus Allii 10-20 weight portion, 8-16 weight portion, Rhizoma Dioscoreae 10-30 weight portion, Radix Et Caulis Acanthopanacis Senticosi 7-14 weight portion, Semen Pittospori Glabrati 11-21 weight portion, Herba Boschniakiae Rossicae 12-32 weight portion, Climbing Viloet Herb 10-20 weight portion and Pueraria lobota 12-28 weight portion.
In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Herba Urariae crinitae 8-13 weight portion, Moschus 12-20 weight portion, Sargassum 7-12 weight portion, Serissa foetida 12-20 weight portion, Radix Rumicis Patientiae 15-28 weight portion, Herba silenes fortunei 9-18 weight portion, Bulbus Lilii 12-30 weight portion, Rhizoma Curcumae 10-16 weight portion, Flos Farfarae 14-30 weight portion, Semen Cassiae 12-20 weight portion, Aleuritopteris argentea (Gmel.) Fee 15-30 weight portion, Herba Christiae Obcordatae 8-15 weight portion, Flos Plumeriae Acutifoliae 12-30 weight portion, Ganoderma 14-22 weight portion, Flos Magnoliae Officinalis 15-30 weight portion, Lasiosphaera Seu Calvatia 12-20 weight portion, Partition in Fructus Juglandis 15-28 weight portion, Caulis Tinosporae 14-20 weight portion, halberd Ye Wawei 15-35 weight portion, Bulbus Allii 10-20 weight portion, 9-15 weight portion, Rhizoma Dioscoreae 10-30 weight portion, Radix Et Caulis Acanthopanacis Senticosi 7-12 weight portion, Semen Pittospori Glabrati 12-20 weight portion, Herba Boschniakiae Rossicae 14-30 weight portion, Climbing Viloet Herb 15-20 weight portion and Pueraria lobota 13-26 weight portion.
In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Herba Urariae crinitae 12 weight portion, Moschus 20 weight portion, Sargassum 9 weight portion, Serissa foetida 16 weight portion, Radix Rumicis Patientiae 24 weight portion, Herba silenes fortunei 15 weight portion, Bulbus Lilii 25 weight portion, Rhizoma Curcumae 15 weight portion, Flos Farfarae 30 weight portion, Semen Cassiae 16 weight portion, Aleuritopteris argentea (Gmel.) Fee 20 weight portion, Herba Christiae Obcordatae 13 weight portion, Flos Plumeriae Acutifoliae 24 weight portion, Ganoderma 15 weight portion, Flos Magnoliae Officinalis 28 weight portion, Lasiosphaera Seu Calvatia 15 weight portion, Partition in Fructus Juglandis 26 weight portion, Caulis Tinosporae 18 weight portion, halberd Ye Wawei 32 weight portion, Bulbus Allii 15 weight portion, 13 weight portions, Rhizoma Dioscoreae 20 weight portion, Radix Et Caulis Acanthopanacis Senticosi 11 weight portion, Semen Pittospori Glabrati 16 weight portion, Herba Boschniakiae Rossicae 25 weight portion, Climbing Viloet Herb 15 weight portion and Pueraria lobota 23 weight portion.
In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Herba Urariae crinitae 12 weight portion, Moschus 16 weight portion, Sargassum 9 weight portion, Serissa foetida 18 weight portion, Radix Rumicis Patientiae 24 weight portion, Herba silenes fortunei 15 weight portion, Bulbus Lilii 25 weight portion, Rhizoma Curcumae 15 weight portion, Flos Farfarae 30 weight portion, Semen Cassiae 18 weight portion, Aleuritopteris argentea (Gmel.) Fee 20 weight portion, Herba Christiae Obcordatae 12 weight portion, Flos Plumeriae Acutifoliae 30 weight portion, Ganoderma 21 weight portion, Flos Magnoliae Officinalis 18 weight portion, Lasiosphaera Seu Calvatia 14 weight portion, Partition in Fructus Juglandis 24 weight portion, Caulis Tinosporae 15 weight portion, halberd Ye Wawei 32 weight portion, Bulbus Allii 12 weight portion, 9 weight portions, Rhizoma Dioscoreae 20 weight portion, Radix Et Caulis Acanthopanacis Senticosi 9 weight portion, Semen Pittospori Glabrati 17 weight portion, Herba Boschniakiae Rossicae 25 weight portion, Climbing Viloet Herb 19 weight portion and Pueraria lobota 13 weight portion.
In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Herba Urariae crinitae 7-14 weight portion, Moschus 10-20 weight portion, Sargassum 6-12 weight portion, Serissa foetida 11-21 weight portion, Radix Rumicis Patientiae 14-28 weight portion, Herba silenes fortunei 8-19 weight portion, Bulbus Lilii 10-30 weight portion, Rhizoma Curcumae 9-18 weight portion, Flos Farfarae 12-32 weight portion, Semen Cassiae 12-21 weight portion, Aleuritopteris argentea (Gmel.) Fee 10-30 weight portion, Herba Christiae Obcordatae 8-16 weight portion, Flos Plumeriae Acutifoliae 12-32 weight portion, Ganoderma 13-23 weight portion, Flos Magnoliae Officinalis 13-31 weight portion, Lasiosphaera Seu Calvatia 11-21 weight portion, Partition in Fructus Juglandis 14-28 weight portion, Caulis Tinosporae 12-22 weight portion, halberd Ye Wawei 13-36 weight portion, Bulbus Allii 10-20 weight portion, 8-16 weight portion, Rhizoma Dioscoreae 10-30 weight portion, Radix Et Caulis Acanthopanacis Senticosi 7-14 weight portion, Semen Pittospori Glabrati 11-21 weight portion, Herba Boschniakiae Rossicae 12-32 weight portion, Climbing Viloet Herb 10-20 weight portion, Pueraria lobota 12-28 weight portion, Corm Eleocharitis 10-20 weight portion, Fructus Papaveris nudicaulis 2-4 weight portion, Folium Vaccinii Bracteati 14-32 weight portion, fructus hippophae 15-25 weight portion and Radix Notoginseng 10-20 weight portion.
In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Herba Urariae crinitae 12 weight portion, Moschus 16 weight portion, Sargassum 9 weight portion, Serissa foetida 18 weight portion, Radix Rumicis Patientiae 24 weight portion, Herba silenes fortunei 15 weight portion, Bulbus Lilii 25 weight portion, Rhizoma Curcumae 15 weight portion, Flos Farfarae 30 weight portion, Semen Cassiae 18 weight portion, Aleuritopteris argentea (Gmel.) Fee 20 weight portion, Herba Christiae Obcordatae 12 weight portion, Flos Plumeriae Acutifoliae 30 weight portion, Ganoderma 21 weight portion, Flos Magnoliae Officinalis 18 weight portion, Lasiosphaera Seu Calvatia 14 weight portion, Partition in Fructus Juglandis 24 weight portion, Caulis Tinosporae 15 weight portion, halberd Ye Wawei 32 weight portion, Bulbus Allii 12 weight portion, 9 weight portions, Rhizoma Dioscoreae 20 weight portion, Radix Et Caulis Acanthopanacis Senticosi 9 weight portion, Semen Pittospori Glabrati 17 weight portion, Herba Boschniakiae Rossicae 25 weight portion, Climbing Viloet Herb 19 weight portion, Pueraria lobota 13 weight portion, Corm Eleocharitis 20 weight portion, Fructus Papaveris nudicaulis 3 weight portion, Folium Vaccinii Bracteati 32 weight portion, fructus hippophae 24 weight portion and Radix Notoginseng 14 weight portion.
When the dosage form of described pharmaceutical composition is granule, its preparation method comprises the following steps:
The first step, each for described pharmaceutical composition raw medicinal material is mixed in described ratio, add the ethanol that determining alcohol is 85%～95% relative to 4～8 times of mixture, heat to boiling reflux 3～5 hours, filter, adopt percolation with the speed slowly percolation of 1～2ml per minute, collect percolate, being evaporated to relative density when 50～60 DEG C subsequently under vacuum 0.06～0.09Mpa is the mastic of 1.04～1.10, spray drying, the inlet temperature of spray dryer 160～175 DEG C, leaving air temp 80～85 DEG C, be ground into powder subsequently, make dried cream powder;
Second step, adds the dextrin of the cane sugar powder relative to dried cream powder quality 0.2～0.4 times and 0.1～0.2 times in the dried cream powder obtained, makes granule, dries in 40～50 DEG C, it is thus achieved that granule.
When the dosage form of described pharmaceutical composition is syrup, its preparation method comprises the following steps:
The first step, Radix Rumicis Patientiae, Herba silenes fortunei, Bulbus Lilii and Rhizoma Curcumae are mixed in described ratio, add the ethanol that determining alcohol is 80%～90% relative to 4～6 times of mixture, heating and refluxing extraction 2～4 times, each reflux, extract, 2 hours～3 hours, united extraction liquid, with the centrifugal remove impurity of tube centrifuge, when extracting solution after remove impurity is evaporated to 60 DEG C in 60 DEG C～70 DEG C when, relative density is the medicinal liquid of 1.05～1.10, concentrated solution spray dryer after concentration is dried, it is ground into 100～200 orders subsequently, it is thus achieved that dry powder;
Second step, Semen Pittospori Glabrati, Herba Boschniakiae Rossicae, Climbing Viloet Herb and Pueraria lobota are mixed in described ratio, is ground into powder, with the ethanol that determining alcohol is 85%～95% as solvent, impregnate 48 hours～72 hours, adopting percolation with the speed slowly percolation of 1～2ml per minute, collect percolate, being concentrated into relative density when 60 DEG C is the mastic of 1.25～1.27, dry with spray dryer, being ground into 100～200 orders subsequently, it is thus achieved that dry powder, the quality of affiliated ethanol is 3～5 times of second step mixture quality;
3rd step, surplus stock medical material is mixed in described ratio, add relative to the alcohol reflux that mixture 4～6 times amount determining alcohol is 70%～80% 2～4 times, each 1 hour～3 hours, filtering respectively, each time filtrate merges, reclaim ethanol, being concentrated into relative density when 60 DEG C is the mastic of 1.20～1.22, dries in 55 DEG C～65 DEG C reduced vacuum, obtains dry powder;
4th step, the dry powder blend that the first step is obtained to the 3rd step, add the water dissolution relative to mixture quality 3～5 times, pH value is regulated to 7.0 with 40% sodium hydroxide solution, it is subsequently added powder mixture quality 30～60% sucrose, 0.1～0.3% potassium sorbate mix homogeneously that obtain relative to the first step to the 3rd step, obtains syrup.
When the dosage form of described pharmaceutical composition is injectable powder, its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, putting into the mixed powder that the micron particles being ground into 0.1～10 μm of volume average particle size in super micron mill and particle diameter form less than the nano-scale particle of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%;
Second step, the mixed powder that the first step obtains adds the ethanol that determining alcohol is 85%～95% of the quality 3～5 times relative to described mixed powder, stirring and dissolving obtains alcoholic solution, alcoholic solution is stood 24～36 hours when 5 DEG C～10 DEG C, adopt percolation with the speed slowly percolation of 1～2ml per minute, collect percolate, concentrate and dry, and pulverizing 40～60 minutes in super micron mill are put at this, the mixed powder that the micron particles of 0.1～10 μm of volume average particle size of acquisition and particle diameter form less than the nano-scale particle of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, takes mixed powder 10g～20g that second step obtains, and adds propylene glycol 30g～50g, adds 200ml water for injection, and stirring makes it dissolve, and injects water to 1000ml further, adds 1g～1.5g needle-use activated carbon, is sufficiently stirred for 30～50 minutes; Decarbonization filtering; With 0.22～0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.
Hereinafter adopting embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the process that realizes reaching technique effect can fully understand and implement according to this.
Embodiment 1 granule
The manufacturing process of granule of the present invention is: take Herba Urariae crinitae 120g, Moschus 200g, Sargassum 90g, Serissa foetida 160g, Radix Rumicis Patientiae 240g, Herba silenes fortunei 150g, Bulbus Lilii 250g, Rhizoma Curcumae 150g, Flos Farfarae 300g, Semen Cassiae 160g, Aleuritopteris argentea (Gmel.) Fee 200g, Herba Christiae Obcordatae 130g, Flos Plumeriae Acutifoliae 240g, Ganoderma 150g, Flos Magnoliae Officinalis 280g, Lasiosphaera Seu Calvatia 150g, Partition in Fructus Juglandis 260g, Caulis Tinosporae 180g, halberd Ye Wawei 320g, Bulbus Allii 150g, 130g, Rhizoma Dioscoreae 200g, Radix Et Caulis Acanthopanacis Senticosi 110g, Semen Pittospori Glabrati 160g, Herba Boschniakiae Rossicae 250g, Climbing Viloet Herb 150g and Pueraria lobota 230g,
The first step, each for described pharmaceutical composition raw medicinal material is mixed in described ratio, adds the ethanol that determining alcohol is 90% relative to 6 times of mixture, heat to boiling reflux 4 hours, filter, adopting percolation with the speed slowly percolation of 1.5ml per minute, collect percolate, being evaporated to relative density when 55 DEG C subsequently under vacuum 0.07Mpa is the mastic of 1.07, spray drying, the inlet temperature of spray dryer 165 DEG C, leaving air temp 80 DEG C, be ground into powder subsequently, make dried cream powder;
Second step, adds the dextrin of the cane sugar powder relative to dried cream powder quality 0.3 times and 0.15 times in the dried cream powder obtained, makes granule, dries in 45 DEG C, it is thus achieved that granule.
Embodiment 2 syrup
The manufacturing process of syrup of the present invention is: take Herba Urariae crinitae 120g, Moschus 160g, Sargassum 90g, Serissa foetida 180g, Radix Rumicis Patientiae 240g, Herba silenes fortunei 150g, Bulbus Lilii 250g, Rhizoma Curcumae 150g, Flos Farfarae 300g, Semen Cassiae 180g, Aleuritopteris argentea (Gmel.) Fee 200g, Herba Christiae Obcordatae 120g, Flos Plumeriae Acutifoliae 300g, Ganoderma 210g, Flos Magnoliae Officinalis 180g, Lasiosphaera Seu Calvatia 140g, Partition in Fructus Juglandis 240g, Caulis Tinosporae 150g, halberd Ye Wawei 320g, Bulbus Allii 120g, 90g, Rhizoma Dioscoreae 200g, Radix Et Caulis Acanthopanacis Senticosi 90g, Semen Pittospori Glabrati 170g, Herba Boschniakiae Rossicae 250g, Climbing Viloet Herb 190g and Pueraria lobota 130g,
The first step, Radix Rumicis Patientiae, Herba silenes fortunei, Bulbus Lilii and Rhizoma Curcumae are mixed in described ratio, add the ethanol that determining alcohol is 85% relative to 5 times of mixture, heating and refluxing extraction 3 times, each reflux, extract, 2.5 hours, united extraction liquid, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity is evaporated to 60 DEG C in 65 DEG C when, relative density is the medicinal liquid of 1.07, is dried by the concentrated solution spray dryer after concentration, it is ground into 150 orders subsequently, it is thus achieved that dry powder;
Second step, Semen Pittospori Glabrati, Herba Boschniakiae Rossicae, Climbing Viloet Herb and Pueraria lobota are mixed in described ratio, is ground into powder, with the ethanol that determining alcohol is 90% as solvent, impregnate 62 hours, adopting percolation with the speed slowly percolation of 2ml per minute, collect percolate, being concentrated into relative density when 60 DEG C is the mastic of 1.26, dry with spray dryer, being ground into 200 orders subsequently, it is thus achieved that dry powder, the quality of affiliated ethanol is 4 times of second step mixture quality;
3rd step, surplus stock medical material is mixed in described ratio, add relative to the alcohol reflux that mixture 5 times amount determining alcohol is 75% 3 times, each 2 hours, filtering respectively, each time filtrate merges, reclaim ethanol, being concentrated into relative density when 60 DEG C is the mastic of 1.21, dries in 60 DEG C of reduced vacuum, obtains dry powder;
4th step, the dry powder blend that the first step is obtained to the 3rd step, add the water dissolution relative to mixture quality 4 times, pH value is regulated to 7.0 with 40% sodium hydroxide solution, it is subsequently added powder mixture quality 50% sucrose, the 0.2% potassium sorbate mix homogeneously that obtain relative to the first step to the 3rd step, obtains syrup.
Embodiment 3 injectable powder
The manufacturing process of the injectable powder of the present invention is: take Herba Urariae crinitae 120g, Moschus 160g, Sargassum 90g, Serissa foetida 180g, Radix Rumicis Patientiae 240g, Herba silenes fortunei 150g, Bulbus Lilii 250g, Rhizoma Curcumae 150g, Flos Farfarae 300g, Semen Cassiae 180g, Aleuritopteris argentea (Gmel.) Fee 200g, Herba Christiae Obcordatae 120g, Flos Plumeriae Acutifoliae 300g, Ganoderma 210g, Flos Magnoliae Officinalis 180g, Lasiosphaera Seu Calvatia 140g, Partition in Fructus Juglandis 240g, Caulis Tinosporae 150g, halberd Ye Wawei 320g, Bulbus Allii 120g, 90g, Rhizoma Dioscoreae 200g, Radix Et Caulis Acanthopanacis Senticosi 90g, Semen Pittospori Glabrati 170g, Herba Boschniakiae Rossicae 250g, Climbing Viloet Herb 190g, Pueraria lobota 130g, Corm Eleocharitis 200g, Fructus Papaveris nudicaulis 30g, Folium Vaccinii Bracteati 320g, fructus hippophae 240g and Radix Notoginseng 140g,
The first step, described raw medicinal material is mixed in proportion, putting into the mixed powder that the micron particles being ground into 0.7 μm of volume average particle size in super micron mill and particle diameter form less than the nano-scale particle of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%;
Second step, the mixed powder that the first step obtains adds the ethanol that determining alcohol is 90% of the quality 4 times relative to described mixed powder, stirring and dissolving obtains alcoholic solution, alcoholic solution is stood 32 hours when 7 DEG C, adopt percolation with the speed slowly percolation of 2ml per minute, collect percolate, concentrate and dry, and pulverizing 50 minutes in super micron mill are put at this, the mixed powder that the micron particles of 0.8 μm of volume average particle size of acquisition and particle diameter form less than the nano-scale particle of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, takes the mixed powder 15g that second step obtains, and adds propylene glycol 40g, adds 200ml water for injection, and stirring makes it dissolve, and injects water to 1000ml further, adds 1.5g needle-use activated carbon, is sufficiently stirred for 40 minutes;Decarbonization filtering; With 0.23 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.
Injection toxicity test:
(1) animal selects
Cleaning grade kunming mice 40, male and female half and half, body weight 18-22g; Laboratory observation 1 week, fasting 4h before administration, can't help water every time.
(2) test packet
By above cleaning grade kunming mice laboratory observation 1 week, the cleaning grade kunming mice that clinical observation result is healthy is randomly divided into two groups, often 20 (male and female half and half) of group. One of which is set as experimental group, and another group is set as matched group.
(3) medication and dosage
Mouse tail vein injection, experimental group is with successive administration 3 times in maximum (former) concentration of the embodiment of the present invention 3 and maximum volume 24h, give 0.6ml/20g(Mouse Weight) medicine, i.e. the injection 1.8g(crude drug amount of mouse tail vein injection embodiment 1 in 24h)/20g(Mouse Weight); Matched group is to the injection normal saline of same volume.
(4) observational technique and index
Weigh the weight of animals before administration and observe feed intake and drinking-water situation; After administration, every day weighs the weight of animals, feed intake and undue toxicity's symptom, Continuous Observation 14d in the identical time. Observation index is as follows: 1. take action, such as unease, many dynamic, sounding; 2. nervous system reaction, as lifted tail, chatter, spasm, movement disorder, attitude extremely; 3. autonomic nervous system reaction, as exophthalmos, sialorrhea, shed tears, urinate, drop, perpendicular hair, dyschromasia, adnormal respiration; 4. drinking-water and appetite change, defecation and color thereof, whether nose, eye, oral cavity be with or without abnormal secretion thing, body weight change; 5. death condition.
(5) experimental result
By the observation of 14d, two groups all do not have undue toxicity to react appearance, also without occur animal dead phenomenon. Therefore, the injection of the embodiment of the present invention 3 has no side effect.
Long term toxicity test: by the granule of the embodiment of the present invention 1 to mice by 6.43,15.72 and 36.41g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal 4 weeks after, result shows: the indexs such as the hair of mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat are all had no significant effect by pharmaceutical composition of the present invention, internal organs naked eyes do not find that difference change and histological indications show, after medication 16 weeks and drug withdrawal 4 weeks, Organs of Mice is all without substantially changing. Illustrate that pharmaceutical composition of the present invention is little to toxicity after mice long-term prescription, react also without difference after drug withdrawal, application safety.
Cumulative toxicity test is reported: test method: select 20 healthy mices, female, male each 10, with the syrup of the embodiment of the present invention 2 for object, dose design is a phase in every 5 days, each issue dosage respectively 0.10LD50,0.15LD50,0.22LD50,0.34LD50,0.50LD50, the LD50 female, male mice of this sample be 5000m part/k part BW (five dosage is 500,750,1100,1700,2500m part/k part BW). Within every 5 days, weigh once, adjust dosage, by 0.1ml/10 part BW per os gavage. After 20 days, animal occurs without death condition, off-test, and by ascending-dose to after tested material 20 days, female, buck all occurs without death condition.
Clinical data:
Case selection: select in October, 2014 to outpatient service in October, 2015 or be in hospital 200 example infant spleen-deficient diarrhea patients, age 1-5 month, on average (6 ± 0.7) individual month, above-mentioned infant is all suffered from diarrhoea and is not healed, soft stools, with white milk block, loss of appetite, become thin the rotavirus enteritis later stage weak, common, after routine blood test, stool microscopy etc. check, determine diagnosis spleen-deficient diarrhoea.Through statistical analysis it can be seen that above-mentioned infant sex, the monthly age compares time no significant difference, therefore there is comparability; 200 example infants are randomly divided into Granules in Treating group, syrup treatment group, injectable powder treatment group and matched group, each experimental group 50 people.
Diagnostic criteria: the diagnostic criteria proposed according to " paediatric internal medicine " (in May, 1987 second edition Qi Jiayi chief editor), all cases diarrhoea does not heal, soft stools, with white milk block, loss of appetite, becomes thin weak. Common rotavirus enteritis later stage or chronic diarrhea unhealed.
Therapeutic Method:
In medicine composite for curing group:
Granules in Treating group: take the embodiment of the present invention 1 preparation granule, every day 3 times, one time 2 bags, every bag of 0.6g, every 3 days is a course for the treatment of;
Syrup treatment group: using the embodiment of the present invention 2 to prepare syrup, every day 3 times, 10ml/ time, every 3 days be 1 course for the treatment of;
Injectable powder treatment group: use the injectable powder intravenous drip of the embodiment of the present invention 3 preparation, fully dissolve with appropriate water for injection, then dilute with 5% glucose injection 500ml, every day 1 time, each per kilogram of body weight 10mg, every 3 days is a course for the treatment of.
Matched group: take bacillus subtilis bigeminy viable bacteria granular, every day 2 times, one time 2 bags, every bag of 1g, every 3 days is a course for the treatment of.
The standard of curative effect evaluation: can about the subproposal of diarrhoeal diseases curative effect judging standard with reference to national diarrhoeal diseases preventing and treating academic research in 1998. Effective: in treatment 72h, feces character and number of times recover normal, and General Symptoms disappears; Effective: during treatment 72h, feces character and number of times are clearly better, and General Symptoms is obviously improved; Invalid: during treatment 72h, feces character, number of times and General Symptoms all even worsen without taking a turn for the better.
Therapeutic outcome:
Referring to table 1 and table 2, as it can be seen from table 1 adopt the medicine composite for curing infant spleen-deficient diarrhoea of the present invention, relative to conventional medicament on therapeutic effect, have and be markedly improved; From table 2 it can be seen that adopt the medicine composite for curing infant spleen-deficient diarrhoea of the present invention, relative to conventional medicament, treating, the course for the treatment of significantly shortens.
Table 1 respectively organize respectively treatment 4 courses for the treatment of after Clinical efficacy comparison example
Group Number of cases Effective number Significant figure Invalid number Total effective rate (%)
Granules in Treating group 50 46 3 1 98%
Syrup treatment group 50 48 1 1 98%
Injectable powder treatment group 50 50 0 0 100%
Matched group 50 22 17 11 78%
2 four groups of table is effective and efficiently individual quantity time comparative example (%) after treating 4 courses for the treatment of respectively
Group Number of cases 1st course for the treatment of 2nd course for the treatment of 3rd course for the treatment of 4th course for the treatment of
Granules in Treating group 49 11(22.4%) 12(24.5%) 13(26.5%) 13(26.5%)
Syrup treatment group 49 11(22.4%) 12(24.5%) 13(26.5%) 13(26.5%)
Injectable powder treatment group 50 12(24%) 12(24%) 13(26%) 13(26%)
Matched group 39 1(2.6%) 3(7.7%) 5(12.8%) 30(76.9%)
According to the clinical statistics in above table it can be seen that medicine provided by the invention have rapid-action, effective percentage is high, determined curative effect, safety is high, have no side effect; 148 examples of simultaneously that treatment group is effective and efficiently individual quantity and the effective and effective 39 example follow-up of patients of matched group 1 year half, result is added up, and in Granules in Treating group 49 example, effective 46 examples are without recurrence, 1 case relapsed in effective 3 examples, and relapse rate is 2%; In syrup treatment group 49 example, effective 48 examples are without recurrence, 1 case relapsed in effective 1 example, and relapse rate is 2%;All without recurrence in effective 50 in injectable powder treatment group 50 example, relapse rate is 0%; Matched group is effective and efficiently individual quantity 39 example, recurs 5 examples, recur 7 examples, relapse rate 30.77% in effective 17 example patients in 22 effective example patients; Above-mentioned recurrence refer to patient outcomes reach effective or effectively after, 1 year half followed up a case by regular visits to substantially occurs the symptom before treatment.
Model case: Wang, male, 6 monthly ages, in November, 2014, diarrhoea does not heal, soft stools, with white milk block, loss of appetite, become thin weak, determine diagnosis infantile diarrhea through routine blood test, stool microscopy etc. after checking, then hopes according to the traditional Chinese medical science, hear, ask, cut and be diagnosed as infant spleen-deficient further and suffer from diarrhoea; Take the granule of Medications Example 1 of the present invention, every day 3 times, one time 2 bags, every bag of 0.6g, medication is substantially effective for one course for the treatment of, continues medication two weeks effective, follows up a case by regular visits to and do not recur for 1 year half.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all within the spirit and principles in the present invention, any amendment of making, equivalent replacement, improvement etc., should be included within protection scope of the present invention.

Claims (10)

1. the pharmaceutical composition treating infant spleen-deficient diarrhoea, it is characterized in that, be made up of following raw medicinal material: Herba Urariae crinitae, Moschus, Sargassum, Serissa foetida, Radix Rumicis Patientiae, Herba silenes fortunei, Bulbus Lilii, Rhizoma Curcumae, Flos Farfarae, Semen Cassiae, Aleuritopteris argentea (Gmel.) Fee, Herba Christiae Obcordatae, Flos Plumeriae Acutifoliae, Ganoderma, Flos Magnoliae Officinalis, Lasiosphaera Seu Calvatia, Partition in Fructus Juglandis, Caulis Tinosporae, halberd Ye Wawei, Bulbus Allii, Rhizoma Dioscoreae, Radix Et Caulis Acanthopanacis Senticosi, Semen Pittospori Glabrati, Herba Boschniakiae Rossicae, Climbing Viloet Herb and Pueraria lobota.
2. according to claim 1, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Herba Urariae crinitae 7-14 weight portion, Moschus 10-20 weight portion, Sargassum 6-12 weight portion, Serissa foetida 11-21 weight portion, Radix Rumicis Patientiae 14-28 weight portion, Herba silenes fortunei 8-19 weight portion, Bulbus Lilii 10-30 weight portion, Rhizoma Curcumae 9-18 weight portion, Flos Farfarae 12-32 weight portion, Semen Cassiae 12-21 weight portion, Aleuritopteris argentea (Gmel.) Fee 10-30 weight portion, Herba Christiae Obcordatae 8-16 weight portion, Flos Plumeriae Acutifoliae 12-32 weight portion, Ganoderma 13-23 weight portion, Flos Magnoliae Officinalis 13-31 weight portion, Lasiosphaera Seu Calvatia 11-21 weight portion, Partition in Fructus Juglandis 14-28 weight portion, Caulis Tinosporae 12-22 weight portion, halberd Ye Wawei 13-36 weight portion, Bulbus Allii 10-20 weight portion, 8-16 weight portion, Rhizoma Dioscoreae 10-30 weight portion, Radix Et Caulis Acanthopanacis Senticosi 7-14 weight portion, Semen Pittospori Glabrati 11-21 weight portion, Herba Boschniakiae Rossicae 12-32 weight portion, Climbing Viloet Herb 10-20 weight portion and Pueraria lobota 12-28 weight portion.
3. the pharmaceutical composition for the treatment of infant spleen-deficient according to claim 1 and 2 diarrhoea, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Herba Urariae crinitae 8-13 weight portion, Moschus 12-20 weight portion, Sargassum 7-12 weight portion, Serissa foetida 12-20 weight portion, Radix Rumicis Patientiae 15-28 weight portion, Herba silenes fortunei 9-18 weight portion, Bulbus Lilii 12-30 weight portion, Rhizoma Curcumae 10-16 weight portion, Flos Farfarae 14-30 weight portion, Semen Cassiae 12-20 weight portion, Aleuritopteris argentea (Gmel.) Fee 15-30 weight portion, Herba Christiae Obcordatae 8-15 weight portion, Flos Plumeriae Acutifoliae 12-30 weight portion, Ganoderma 14-22 weight portion, Flos Magnoliae Officinalis 15-30 weight portion, Lasiosphaera Seu Calvatia 12-20 weight portion, Partition in Fructus Juglandis 15-28 weight portion, Caulis Tinosporae 14-20 weight portion, halberd Ye Wawei 15-35 weight portion, Bulbus Allii 10-20 weight portion, 9-15 weight portion, Rhizoma Dioscoreae 10-30 weight portion, Radix Et Caulis Acanthopanacis Senticosi 7-12 weight portion, Semen Pittospori Glabrati 12-20 weight portion, Herba Boschniakiae Rossicae 14-30 weight portion, Climbing Viloet Herb 15-20 weight portion and Pueraria lobota 13-26 weight portion.
4. the pharmaceutical composition of the treatment infant spleen-deficient diarrhoea according to any one of claim 1-3, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Herba Urariae crinitae 12 weight portion, Moschus 20 weight portion, Sargassum 9 weight portion, Serissa foetida 16 weight portion, Radix Rumicis Patientiae 24 weight portion, Herba silenes fortunei 15 weight portion, Bulbus Lilii 25 weight portion, Rhizoma Curcumae 15 weight portion, Flos Farfarae 30 weight portion, Semen Cassiae 16 weight portion, Aleuritopteris argentea (Gmel.) Fee 20 weight portion, Herba Christiae Obcordatae 13 weight portion, Flos Plumeriae Acutifoliae 24 weight portion, Ganoderma 15 weight portion, Flos Magnoliae Officinalis 28 weight portion, Lasiosphaera Seu Calvatia 15 weight portion, Partition in Fructus Juglandis 26 weight portion, Caulis Tinosporae 18 weight portion, halberd Ye Wawei 32 weight portion, Bulbus Allii 15 weight portion, 13 weight portions, Rhizoma Dioscoreae 20 weight portion, Radix Et Caulis Acanthopanacis Senticosi 11 weight portion, Semen Pittospori Glabrati 16 weight portion, Herba Boschniakiae Rossicae 25 weight portion, Climbing Viloet Herb 15 weight portion and Pueraria lobota 23 weight portion.
5. the pharmaceutical composition of the treatment infant spleen-deficient diarrhoea according to any one of claim 1-4, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Herba Urariae crinitae 12 weight portion, Moschus 16 weight portion, Sargassum 9 weight portion, Serissa foetida 18 weight portion, Radix Rumicis Patientiae 24 weight portion, Herba silenes fortunei 15 weight portion, Bulbus Lilii 25 weight portion, Rhizoma Curcumae 15 weight portion, Flos Farfarae 30 weight portion, Semen Cassiae 18 weight portion, Aleuritopteris argentea (Gmel.) Fee 20 weight portion, Herba Christiae Obcordatae 12 weight portion, Flos Plumeriae Acutifoliae 30 weight portion, Ganoderma 21 weight portion, Flos Magnoliae Officinalis 18 weight portion, Lasiosphaera Seu Calvatia 14 weight portion, Partition in Fructus Juglandis 24 weight portion, Caulis Tinosporae 15 weight portion, halberd Ye Wawei 32 weight portion, Bulbus Allii 12 weight portion, 9 weight portions, Rhizoma Dioscoreae 20 weight portion, Radix Et Caulis Acanthopanacis Senticosi 9 weight portion, Semen Pittospori Glabrati 17 weight portion, Herba Boschniakiae Rossicae 25 weight portion, Climbing Viloet Herb 19 weight portion and Pueraria lobota 13 weight portion.
6. the pharmaceutical composition of the treatment infant spleen-deficient diarrhoea according to any one of claim 1-5, it is characterised in that described pharmaceutical composition also includes: Corm Eleocharitis, Fructus Papaveris nudicaulis, Folium Vaccinii Bracteati, fructus hippophae and Radix Notoginseng.
7. the pharmaceutical composition of the treatment infant spleen-deficient diarrhoea according to any one of claim 1-6, it is characterised in that in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Herba Urariae crinitae 7-14 weight portion, Moschus 10-20 weight portion, Sargassum 6-12 weight portion, Serissa foetida 11-21 weight portion, Radix Rumicis Patientiae 14-28 weight portion, Herba silenes fortunei 8-19 weight portion, Bulbus Lilii 10-30 weight portion, Rhizoma Curcumae 9-18 weight portion, Flos Farfarae 12-32 weight portion, Semen Cassiae 12-21 weight portion, Aleuritopteris argentea (Gmel.) Fee 10-30 weight portion, Herba Christiae Obcordatae 8-16 weight portion, Flos Plumeriae Acutifoliae 12-32 weight portion, Ganoderma 13-23 weight portion, Flos Magnoliae Officinalis 13-31 weight portion, Lasiosphaera Seu Calvatia 11-21 weight portion, Partition in Fructus Juglandis 14-28 weight portion, Caulis Tinosporae 12-22 weight portion, halberd Ye Wawei 13-36 weight portion, Bulbus Allii 10-20 weight portion, 8-16 weight portion, Rhizoma Dioscoreae 10-30 weight portion, Radix Et Caulis Acanthopanacis Senticosi 7-14 weight portion, Semen Pittospori Glabrati 11-21 weight portion, Herba Boschniakiae Rossicae 12-32 weight portion, Climbing Viloet Herb 10-20 weight portion, Pueraria lobota 12-28 weight portion, Corm Eleocharitis 10-20 weight portion, Fructus Papaveris nudicaulis 2-4 weight portion, Folium Vaccinii Bracteati 14-32 weight portion, fructus hippophae 15-25 weight portion and Radix Notoginseng 10-20 weight portion.
8. the pharmaceutical composition of the treatment infant spleen-deficient diarrhoea according to any one of claim 1-7, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Herba Urariae crinitae 12 weight portion, Moschus 16 weight portion, Sargassum 9 weight portion, Serissa foetida 18 weight portion, Radix Rumicis Patientiae 24 weight portion, Herba silenes fortunei 15 weight portion, Bulbus Lilii 25 weight portion, Rhizoma Curcumae 15 weight portion, Flos Farfarae 30 weight portion, Semen Cassiae 18 weight portion, Aleuritopteris argentea (Gmel.) Fee 20 weight portion, Herba Christiae Obcordatae 12 weight portion, Flos Plumeriae Acutifoliae 30 weight portion, Ganoderma 21 weight portion, Flos Magnoliae Officinalis 18 weight portion, Lasiosphaera Seu Calvatia 14 weight portion, Partition in Fructus Juglandis 24 weight portion, Caulis Tinosporae 15 weight portion, halberd Ye Wawei 32 weight portion, Bulbus Allii 12 weight portion, 9 weight portions, Rhizoma Dioscoreae 20 weight portion, Radix Et Caulis Acanthopanacis Senticosi 9 weight portion, Semen Pittospori Glabrati 17 weight portion, Herba Boschniakiae Rossicae 25 weight portion, Climbing Viloet Herb 19 weight portion, Pueraria lobota 13 weight portion, Corm Eleocharitis 20 weight portion, Fructus Papaveris nudicaulis 3 weight portion, Folium Vaccinii Bracteati 32 weight portion, fructus hippophae 24 weight portion and Radix Notoginseng 14 weight portion.
9. the preparation method of the pharmaceutical composition of the treatment infant spleen-deficient diarrhoea according to any one of claim 1-8, it is characterised in that when the dosage form of described pharmaceutical composition is granule, its preparation method comprises the following steps:
The first step, each for described pharmaceutical composition raw medicinal material is mixed in described ratio, add the ethanol that determining alcohol is 85%～95% relative to 4～8 times of mixture, heat to boiling reflux 3～5 hours, filter, adopt percolation with the speed slowly percolation of 1～2ml per minute, collect percolate, being evaporated to relative density when 50～60 DEG C subsequently under vacuum 0.06～0.09Mpa is the mastic of 1.04～1.10, spray drying, the inlet temperature of spray dryer 160～175 DEG C, leaving air temp 80～85 DEG C, be ground into powder subsequently, make dried cream powder;
Second step, adds the dextrin of the cane sugar powder relative to dried cream powder quality 0.2～0.4 times and 0.1～0.2 times in the dried cream powder obtained, makes granule, dries in 40～50 DEG C, it is thus achieved that granule.
10. the preparation method of the pharmaceutical composition of the treatment infant spleen-deficient diarrhoea according to any one of claim 1-8, it is characterised in that when the dosage form of described pharmaceutical composition is syrup, its preparation method comprises the following steps:
The first step, Radix Rumicis Patientiae, Herba silenes fortunei, Bulbus Lilii and Rhizoma Curcumae are mixed in described ratio, add the ethanol that determining alcohol is 80%～90% relative to 4～6 times of mixture, heating and refluxing extraction 2～4 times, each reflux, extract, 2 hours～3 hours, united extraction liquid, with the centrifugal remove impurity of tube centrifuge, when extracting solution after remove impurity is evaporated to 60 DEG C in 60 DEG C～70 DEG C when, relative density is the medicinal liquid of 1.05～1.10, concentrated solution spray dryer after concentration is dried, it is ground into 100～200 orders subsequently, it is thus achieved that dry powder;
Second step, Semen Pittospori Glabrati, Herba Boschniakiae Rossicae, Climbing Viloet Herb and Pueraria lobota are mixed in described ratio, is ground into powder, with the ethanol that determining alcohol is 85%～95% as solvent, impregnate 48 hours～72 hours, adopting percolation with the speed slowly percolation of 1～2ml per minute, collect percolate, being concentrated into relative density when 60 DEG C is the mastic of 1.25～1.27, dry with spray dryer, being ground into 100～200 orders subsequently, it is thus achieved that dry powder, the quality of affiliated ethanol is 3～5 times of second step mixture quality;
3rd step, surplus stock medical material is mixed in described ratio, add relative to the alcohol reflux that mixture 4～6 times amount determining alcohol is 70%～80% 2～4 times, each 1 hour～3 hours, filtering respectively, each time filtrate merges, reclaim ethanol, being concentrated into relative density when 60 DEG C is the mastic of 1.20～1.22, dries in 55 DEG C～65 DEG C reduced vacuum, obtains dry powder;
4th step, the dry powder blend that the first step is obtained to the 3rd step, add the water dissolution relative to mixture quality 3～5 times, pH value is regulated to 7.0 with 40% sodium hydroxide solution, it is subsequently added powder mixture quality 30～60% sucrose, 0.1～0.3% potassium sorbate mix homogeneously that obtain relative to the first step to the 3rd step, obtains syrup.
CN201610087641.4A 2016-02-17 2016-02-17 Medicine composition for treating infant spleen-deficiency type diarrhea and preparing method of medicine composition Pending CN105664026A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103520620A (en) * 2013-10-22 2014-01-22 刘守梅 Traditional Chinese medicinal preparation for treating spleen-stomach deficiency type chronic gastritis and preparation method of traditional Chinese medicinal preparation
CN105079410A (en) * 2015-09-08 2015-11-25 济南舜昊生物科技有限公司 Medicine for treating infant damp-heat type diarrhea and preparation method thereof
CN105079703A (en) * 2015-09-08 2015-11-25 张庆彪 Medicine composition for treating infant spleen deficiency type diarrhea and preparation method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103520620A (en) * 2013-10-22 2014-01-22 刘守梅 Traditional Chinese medicinal preparation for treating spleen-stomach deficiency type chronic gastritis and preparation method of traditional Chinese medicinal preparation
CN105079410A (en) * 2015-09-08 2015-11-25 济南舜昊生物科技有限公司 Medicine for treating infant damp-heat type diarrhea and preparation method thereof
CN105079703A (en) * 2015-09-08 2015-11-25 张庆彪 Medicine composition for treating infant spleen deficiency type diarrhea and preparation method thereof

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Application publication date: 20160615