CN101653473A - Traditional Chinese medicine composition for treating chicken bursa fabricic and preparation method thereof - Google Patents

Abstract

The invention relates to a traditional Chinese medicine composition for treating chicken bursa fabricic, which comprises the following components in portions by weight: 11-15 portions of astragalus root, 11-15 portions of radix isatidis, 11-15 portions of honeysuckle, 25-29 portions of dandelion, 11-15 portions of indigowoad leaf, 6-10 portions of liquorice, 6-10 portions of gesso, and 2-6 portions of brown sugar. The preparation method of the traditional Chinese medicine composition comprises the following steps (1): weighing astragalus root, radix isatidis, honeysuckle, dandelion, indigowoadleaf, liquorice, gesso, and brown sugar as raw materials in portions by weight; (2) decocting the raw materials twice: adding 10 times of water at the first time, soaking for 30 minutes and decoctingfor 2.0h; adding 10 times of water at the second time and decocting for 1.0h; (3) mixing decoction and filtering, concentrating filtrate into plaster (60 DEG C) with relative density larger than or equal to 1.05, thus obtaining the traditional Chinese medicine composition. The invention develops the formula according to the cause and interpretation of chicken bursa fabricic and has good action inclearing away heat and toxic material, quenching thirst, growing fresh, removing swelling and masses, nourishing Qi and strengthening exterior, tonifying qi and controlling blood. The traditional Chinese medicine composition can be absorbed quickly without generating resistance to drugs and has no residue remained in chickens, thereby effectively guaranteeing eating safety of chicken products andeggs.

Description

Be used for the treatment of Chinese medicine composition of chicken bursa fabricic and preparation method thereof

Technical field

The invention belongs to chicken and use Chinese medicine, relate in particular to a kind of Chinese medicine composition for the treatment of chicken bursa fabricic and preparation method thereof.

Background technology

Infectious bursal disease (IBD) claims avian infectious bursa of Fabricius's inflammation again, is a kind of acute, the height contagious disease of the chicken that caused by virus.3--6 chickling pilosity in age in week, the mortality rate height, this virus is serious to the humoral immunization maincenter organ fabricius bursa infringement of chicken, and the lymphocyte generation of disease chicken bursa is suppressed, and can not produce immunoglobulin, cause immunodeficiency disease, this disease takes place in some chicken houses in various degree, has brought serious harm to poultry husbandry, and has caused bigger economic loss, reinforcement keeps the environment conditional stability to the feeding and management of chicken.Also do not have ideal medicine at present, generally with antiserum and yolk antibody treatment, but this type of drug price height is difficult for preserving, and has the danger that infects some disease, so people expect the appearance of novel treatment chicken bursa fabricic medicine.

Summary of the invention

The present invention is in order to overcome deficiency of the prior art, for poultry husbandry provides a kind of curative effect outstanding, and Chinese medicine composition of no drug residue, the treatment chicken bursa fabricic that has no side effect, have no drug resistance and preparation method thereof.

The present invention is achieved through the following technical solutions for achieving the above object, and a kind of Chinese medicine composition for the treatment of chicken bursa fabricic is characterized in that: be made up of following medicine, by weight meter (part)

Radix Astragali 11-15 Radix Isatidis 11-15 Flos Lonicerae 11-15 Herba Taraxaci 25-29

Folium Isatidis 11-15 Radix Glycyrrhizae 6-10 Gypsum Fibrosum 6-10 brown sugar 2-6.

The preparation method of above-mentioned Chinese medicine composition is characterized in that: carry out according to the following steps:

(1) taking by weighing the Radix Astragali, Radix Isatidis, Flos Lonicerae, Herba Taraxaci, Folium Isatidis, Radix Glycyrrhizae, Gypsum Fibrosum, brown sugar by weight is raw material;

(2) decoction adds 10 times of amounts of water twice, the 1 time, soaks 30 minutes, decocts 2.0 hours; Add 10 times of amounts of water for the 2nd time, decocted 1.0 hours;

(3) collecting decoction filters, and filtrate is concentrated into relative density to the clear paste more than or equal to 1.05 (60 ℃), promptly.

The said components medicine is commercially available product, meets the relevant regulations of " Chinese veterinary drug allusion quotation ".

Composition principle of the present invention:

The Radix Astragali: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Meridian distribution of property and flavor, sweet, temperature.Return lung, spleen channel.Modern study shows that the Radix Astragali has the phagocytic function that strengthens reticuloendothelial system, and blood leukocytes and multinuclear leucocyte quantity are significantly increased, and humoral immunization, cellular immunization are all had facilitation, has the ability of enhanced virus inducement interferon;

Radix Isatidis: have heat clearing away, detoxifcation, the effect of removing heat from blood.Meridian distribution of property and flavor: hardship, cold, go into liver, stomach blood system.Be used for the treatment of influenza, erysipelas, pyretic toxicity is sent out speckle etc.Radix Isatidis has the internal energy pyrogen effect that causes fervescence of significant removing body, realizes by killing pathogen, the factors such as harmful peroxy radical and pyrogen of removing such as intravital virus and bacteria.

Flos Lonicerae: have heat-clearing and toxic substances removing, wind-heat dissipating.Be mainly used in treatment carbuncle furuncle, sore throat, erysipelas, warm blood fulminant dysentery, anemopyretic cold, epidemic febrile disease heating.Meridian distribution of property and flavor, sweet, cold.Return lung, the heart, stomach warp.Can promote lymphocytic conversion, and lymhocyte transformation rate can reflect cellular immune function, i.e. human body immunity improving power.Flos Lonicerae can also strengthen leukocytic phagocytic function, improves immunologic function from another angle.Flos Lonicerae can also promote the release of adrenocortical hormone, and acute inflammation is had the obvious suppression effect.Effective ingredient is a chlorogenic acid, and main biological activity has (1) inhibitory action to hyaluronidase and G-6-Pase; (2) to the removing and the lipoid peroxidization resistant of free radical; (3) antimutagenesis; (4) hepatic cholagogic effect; (5) effect such as antibiotic, antiviral and spasmolytic.

Herba Taraxaci: have heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, the effect of inducing diuresis for treating stranguria syndrome is mainly used in treatment sore, acute mastitis, lung abscess, conjunctival congestion, pharyngalgia, jaundice due to damp-heat, pyretic stranguria.Meridian distribution of property and flavor is bitter, sweet, cold.Return liver, stomach warp.Contain compositions such as taraxasterol, taraxerol, taraxacin, caffeic acid, choline, inulin.

Folium Isatidis: have heat clearing away, detoxifcation, removing heat from blood, hemostatic effect.Be used for the treatment of epidemic febrile disease intenseness of heat excessive thirst, influenza, acute infectious hepatitis, bacillary dysentery, acute gastroenteritis, acute pneumonia, erysipelas is spitted blood epistaxis, jaundice, dysentery, sore throat, aphtha, swollen ulcer drug.Modern study shows that caused inflammatory reaction has the obvious suppression effect, anti-virus aspect to multiple proinflammatory agent: relevant different virus strain has inhibition or delays cytopathic effect to upper respiratory tract infection.Meridian distribution of property and flavor, hardship, cold.GUIXIN, stomach warp.Heating has tangible refrigeration function to infectiousness, and cooling is fast, and toxicity is little.

Radix Glycyrrhizae: Radix Glycyrrhizae: have invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, the effect of coordinating the actions of various ingredients in a prescription.Meridian distribution of property and flavor: property is flat, flavor is sweet, is mainly used in the treatment weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, cushion toxicity.Be the Chinese medicine of QI invigorating strengthening the spleen simply, have the effect of healthy energy in the accent.

Gypsum Fibrosum: have expelling pathogenic factors from muscles for clearing heat, the effect that relieving restlessness is quenched the thirst is mainly used in and controls the calentura high fever and do not move back, vexed coma, thirsty and dry pharynx, lung-heat dyspnea with rapid respiration, stomach-fire headache, hyperactivity of toxic heat.Promoting tissue regeneration and ulcer healing.Xin Gan, cold.Go into that sun is bright, hands is lunar, the few sun of hands.Cool and can loose, the power of expelling pathogenic factors from the exterior expelling pathogenic factors from muscles is arranged.

Brown sugar: warm in nature, sweet in the mouth, go into spleen, have benefiting QI and nourishing blood, the spleen invigorating warming the stomach, the wind dispelling cold expelling can the invigorating middle warmer emergency and the effect of blood clots absorbing.Temperature and mend it, Wen Ertong it, temperature and loose it contains a kind of composition in sugar, have powerful detoxicating functions, and excrete by lymphoid tissue.Brown sugar contains abundant mineral, vitamin, aminoacid and has also contained compositions such as carotene, riboflavin, nicotinic acid, aminoacid, glucose, and pair cell has the effect of potent antioxidation and maintenance.

Beneficial effect: prescription is based on pathogenetic cognition and the Therapeutic Principle of traditional Chinese veterinary medicine to chicken bursa fabricic, etiology and pathogenesis according to chicken bursa fabricic, using Radix Isatidis, Folium Isatidis, Gypsum Fibrosum heat-clearing and toxic substances removing, granulation promoting in the side quenches the thirst, with the Herba Taraxaci dispersing swelling and dissipating binds, with Radix Astragali invigorating QI to consolidate the body surface resistance, nourishing qi to stop.The brown sugar benefiting QI and nourishing blood, the Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.All medicines share, and play heat clearing away altogether, and granulation promoting, the effect of QI invigorating dissipating blood stasis are quenched the thirst in detoxifcation.This compositions clarity height, absorb soon, can not develop immunity to drugs, particularly chick is taken noresidue in the body of back, and then can ensure the edible safety of people to meat, egg product effectively.

The specific embodiment

Below in conjunction with preferred embodiment, to details are as follows according to the specific embodiment provided by the invention:

Embodiment 1

A kind of Chinese medicine composition that is used for the treatment of chicken bursa fabricic, form by following medicine, every part by 10g, with commercially available Radix Astragali 110g Radix Isatidis 110g Flos Lonicerae 120g Herba Taraxaci 250g Folium Isatidis 150g Radix Glycyrrhizae 100g Gypsum Fibrosum 100g brown sugar 60g, take by weighing raw material by weight, decoct, filter, filtrate concentrating makes the clear paste of relative density to 1.05 (60 ℃), promptly.

Embodiment 2

A kind of Chinese medicine composition that is used for the treatment of chicken bursa fabricic, form by following medicine, every part by 10g, with commercially available Radix Astragali 150g Radix Isatidis 150g Flos Lonicerae 150g Herba Taraxaci 290g Folium Isatidis 110g Radix Glycyrrhizae 60g Gypsum Fibrosum 60g brown sugar 30g, take by weighing raw material by weight, decoct, filter, filtrate concentrating makes the clear paste of relative density to 1.05 (60 ℃), promptly gets a kind of Chinese medicine composition that is used for the treatment of chicken bursa fabricic.

Embodiment 3

A kind of Chinese medicine composition that is used for the treatment of chicken bursa fabricic, form by following medicine, every part by 10g, with commercially available Radix Astragali 140g Radix Isatidis 140g Flos Lonicerae 110g Herba Taraxaci 280g Folium Isatidis 130g Radix Glycyrrhizae 90g Gypsum Fibrosum 90g brown sugar 20g, take by weighing raw material by weight, decoct, filter, filtrate concentrating makes the clear paste of relative density to 1.05 (60 ℃), promptly gets a kind of Chinese medicine composition that is used for the treatment of chicken bursa fabricic.

During use,, mix drink, logotype 3～5 days according to the ratio that every 100ml the present invention converts 50 kilograms in water.

Clinical trial:

Experimental example 1:

The Shandong Province Zheng of specialist that raises chickens the Weifang City come to go to a doctor, surplus 817 meat chickens 3000 of its raising, existing 12 ages in days, among the day before yesterday (during chicken 10 ages in days) the chicken group indivedual chickens occur spirit beat listless, loss of appetite, after it is superseded.Evening, discovery had a lot of chickens above symptom to occur again, arranged white Calx sample loose stool simultaneously, have indivedual chickens frequent from the anus pecking door, and surplus in the of dead 40.Chicken group sickness rate reaches more than 60%, surplus in the of dead 400.Cut open and examine the chicken that dies of illness, chest muscle, lower limb flesh have a large amount of brush shape ecchymosiss, and the liver color and luster is thin out, and quality becomes fragile.The fabricius bursa enlargement is original 2～3 times, and the surface has yellow gel-shaped exudate to adhere to, and there are petechia and ecchymosis in the fabricius bursa surface, the cheesy exudate of interior adularescent, and glandular stomach and muscular stomach intersection have the hemorrhage band of strip, and thymus has the petechia.There is a large amount of fibrinous exudates in air bag, heart, liver, abdominal cavity.Be diagnosed as chicken bursa fabricic.Use this invention according to the ratio that every 100ml the present invention converts 50 kilograms in water, mix drink, the treatment while, strengthen feeding and management, keep the environment conditional stability, in treatment, the sick chicken of off color is in time chosen, carry out the environment spraying disinfection with the disinfectant solution that contains Operand simultaneously.The course of disease is controlled after 3 days.

Experimental example 2:

1800 SANHUANG broiler that Luan County, Hebei province one raiser raises find that the minority chickens occur spirit suddenly and beat listlessly, involve full group very soon, and sick chicken occurs that spirit is depressed, useless exhausted, the fear of cold of appetite, squeeze heap, close drowsiness, the wing of dozing off, hang down of order, and chickens have the anus pecking phenomenon individually.Draw white thickness such as Ovum Gallus domesticus album sample loose stool very soon, the Ovum Gallus domesticus album sample thing of the band Calx sample that has, anus is on every side by the feces severe contamination.Sick chicken serious dehydration, thirsty.After falling ill the 2nd day, sick chicken is increased concurrent life and death and dies.Cut open inspection: subcutaneous muscle is dry and astringent, and chest muscle, leg muscle have obvious petechia and ecchymosis, and mucus increases in the intestinal, cecal tonsil enlargement, hemorrhage, the air bag muddiness, thicken, occur yellow cheesy thing on the air bag, liver is hemorrhage, the kidney enlargement, urate deposition is arranged, and the obvious enlargement of fabricius bursa, edema have yellow gelatin sample thing to be wrapped in around it, indivedual comparable normal person's enlargements of fabricius bursa are more than 2 times, and cloaca has little petechia.The diagnosis chicken bursa fabricic.Use the every 100ml the present invention of this invention finished product to convert the ratio of 50 kilograms in water, mix drink, logotype 4 days is put into sick chicken in the empty hurdle in treatment, looks after especially.After the medication four days, the basic recovery normally.

The above only is preferred embodiment of the present invention, is not structure of the present invention is done any pro forma restriction.Every foundation technical spirit of the present invention all still belongs in the scope of technical scheme of the present invention any simple modification, equivalent variations and modification that above embodiment did.

Claims (2)

1. a Chinese medicine composition for the treatment of chicken bursa fabricic is characterized in that: be made up of following medicine, by weight meter (part)

Radix Astragali 11-15 Radix Isatidis 11-15 Flos Lonicerae 11-15 Herba Taraxaci 25-29

Folium Isatidis 11-15 Radix Glycyrrhizae 6-10 Gypsum Fibrosum 6-10 brown sugar 2-6.

2. method for preparing above-mentioned Chinese medicine composition is characterized in that: carry out according to the following steps:

(1) taking by weighing the Radix Astragali, Radix Isatidis, Flos Lonicerae, Herba Taraxaci, Folium Isatidis, Radix Glycyrrhizae, Gypsum Fibrosum, brown sugar by weight is raw material;

(2) decoction adds 10 times of amounts of water twice, the 1 time, soaks 30 minutes, decocts 2.0 hours; Add 10 times of amounts of water for the 2nd time, decocted 1.0 hours;

(3) collecting decoction filters, and filtrate is concentrated into relative density to the clear paste more than or equal to 1.05 (60 ℃), promptly.