CN101816711A - Effervescent Chinese medicinal composition for curing avian dysentery and preparation method thereof - Google Patents
Effervescent Chinese medicinal composition for curing avian dysentery and preparation method thereof Download PDFInfo
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- CN101816711A CN101816711A CN200910228407A CN200910228407A CN101816711A CN 101816711 A CN101816711 A CN 101816711A CN 200910228407 A CN200910228407 A CN 200910228407A CN 200910228407 A CN200910228407 A CN 200910228407A CN 101816711 A CN101816711 A CN 101816711A
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention relates to an effervescent Chinese medicinal composition for curing avian dysentery and a preparation method thereof. The effervescent Chinese medicinal composition comprises the following components in percentage by weight: 5 to 20 percent of radix scutellariae, 5 to 20 percent of polygonum cuspidatum, 5 to 20 percent of the root of Chinese pulsatilla, 5 to 20 percent of radix sophorae flavescentis, 5 to 20 percent of isatis root, 5 to 20 percent of male fern rhizome, 5 to 20 percent of folium isatidis, 10 to 30 percent of effervescing agent and 10 to 30 percent of lubricant. The Chinese medicinal composition and the preparation method thereof have the advantages of scientific and reasonable formula, improvement on immunity, no toxic and side effect, no medicinal residue, low cost, convenient use and high bioavailability.
Description
Technical field
The invention belongs to poultry and use field of veterinary, especially a kind of effervescent Chinese medicinal composition for the treatment of avian dysentery and preparation method thereof.
Background technology
China is livestock and poultry cultivation big country, and the R﹠D work of treatment livestock and poultry medicine did not all stop all the time.In the face of the market trend who becomes better and better, countries in the world require also more and more higher to edible safety, along with progress of science and technology, increasing drug residue is detected and confirms health harmful, countries in the world are all in the supervision that strengthens the residual problem of medicine, this has also produced no small impact to China's livestock and poultry breeding industry, and has proposed a urgent problem.Avian dysentery belong in the poultry farming process occurred frequently, easily send out disease, the vital interests that threatening the raiser all the time in whole culture-cycle process.This disease transmission is strong, and the fatality rate height untimelyly will cause heavy losses to the raiser in case treat.Easily absorption, effervescent Chinese medicine rapid-action, that cure rate is high are subjected to liking of numerous raisers deeply.
Summary of the invention
The object of the present invention is to provide a kind of effervescent Chinese medicinal composition for the treatment of avian dysentery, this Chinese medicine composition composition formula is formed scientific and reasonable, can effectively improve immunity, have no side effect and drug residue, production cost is lower, and is easy to use, the bioavailability height.
Another object of the present invention is to provide a kind of preparation method for the treatment of the effervescent Chinese medicinal composition of avian dysentery.
The present invention is achieved by the following technical solutions:
A kind of effervescent Chinese medicinal composition for the treatment of avian dysentery, its Chinese medicinal composition and percentage by weight thereof are:
Radix Scutellariae 5-20%; Rhizoma Polygoni Cuspidati 5-20%; Radix Pulsatillae 5-20%;
Radix Sophorae Flavescentis 5-20%; Radix Isatidis 5-20%; Rhizoma Dryopteris Crassirhizomatis 5-20%;
Folium Isatidis 5-20%; Effervescent 10-30%; Lubricant 10-30%.
And described effervescent is combined by weight 1: 1 by the wherein a kind of and sodium bicarbonate in tartaric acid, citric acid, the adipic acid.
And described lubricant is wherein a kind of in sucralose, erythritol, magnesium stearate, the dodecyl sodium sulfate.
A kind of preparation method for the treatment of the effervescent Chinese medicinal composition of avian dysentery, the step of its preparation method is:
(1) takes by weighing Radix Scutellariae, Rhizoma Polygoni Cuspidati, the Radix Pulsatillae, Radix Sophorae Flavescentis, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Folium Isatidis extracting in water 2 times according to weight proportion, merging filtrate, being concentrated into relative density under 20 ℃ is 1.30～1.35, gets the clear paste drying, pulverize the back all by 80～100 mesh sieves, obtain mixture A;
(2) take by weighing according to weight proportion that effervescent, lubricant are pulverized respectively and all by the mixture A mix homogeneously in 80～100 mesh sieves and the step (2), obtain mixture B;
(3) be binding agent system soft material with mixture B with concentration 50～60% alcoholic solution of 2～4%PVP, and with soft material all by 10～15 mesh sieve system granules, under 50～60 ℃, carry out aeration-drying, make granulate by 20～30 mesh sieves again, promptly obtain the effervescent Chinese medicinal composition of finished product treatment avian dysentery.
Advantage of the present invention and beneficial effect are:
1, this Chinese medicine composition adopts Radix Scutellariae, Rhizoma Polygoni Cuspidati, the Radix Pulsatillae, Radix Sophorae Flavescentis, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Folium Isatidis as the natural Chinese medicine composition, has good heat-clearing and toxic substances removing, the effect of removing dampness dysentery relieving.As the natural Chinese medicines extract, do not have any poisonous and harmful substance simultaneously, can not produce toxic and side effects, more can not exert an influence health to animal body.
2, in the preparation method of this Chinese medicine composition the effervescent technology introduced cleverly in the tablet of this medicine into, can make the dispensing treatment more handy, save a large amount of manpower and materials, effective ingredient in the medicine is dissolved rapidly and uniformly, being convenient to poultry absorbs, improve bioavailability, can significantly improve the clinical efficacy of medicine.
3, the present invention fills a prescription and forms scientific and reasonablely, can effectively improve immunity, has no side effect and drug residue, and production cost is lower, and is easy to use, the bioavailability height.
The specific embodiment
The present invention is described in further detail by following examples.Need to prove: following embodiment is illustrative, is not determinate, can not limit protection scope of the present invention with following embodiment.
Radix Scutellariae in the component of the present invention, Rhizoma Polygoni Cuspidati, the Radix Pulsatillae, Radix Sophorae Flavescentis, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Folium Isatidis, tartaric acid, citric acid, adipic acid, sodium bicarbonate, sucralose, erythritol, magnesium stearate, dodecyl sodium sulfate all can be bought on market and obtain.
Embodiment 1
A kind of effervescent Chinese medicinal composition for the treatment of avian dysentery, its Chinese medicinal composition and weight are respectively: Radix Scutellariae 10kg, Rhizoma Polygoni Cuspidati 10kg, Radix Pulsatillae 10kg, Radix Sophorae Flavescentis 10kg, Radix Isatidis 10kg, Rhizoma Dryopteris Crassirhizomatis 10kg, Folium Isatidis 10kg, effervescent 20Kg, lubricant 10Kg; Above-mentioned effervescent is made up of adipic acid 10Kg and sodium bicarbonate 10Kg, and lubricant is a sucralose.
A kind of effervescent Chinese medicinal composition for the treatment of avian dysentery, the step of its preparation method is:
(1) takes by weighing Radix Scutellariae, Rhizoma Polygoni Cuspidati, the Radix Pulsatillae, Radix Sophorae Flavescentis, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Folium Isatidis extracting in water 2 times according to weight proportion, merging filtrate, being concentrated into relative density under 20 ℃ is 1.3, gets the clear paste drying, pulverize the back all by 80 mesh sieves, obtain mixture A;
(2) take by weighing according to weight proportion that effervescent, lubricant are pulverized respectively and all by the mixture A mix homogeneously in 80～100 mesh sieves and the step (2), obtain mixture B;
(3) be binding agent system soft material with mixture B with 50% alcoholic solution of 2%PVP, and with soft material all by 10 mesh sieve system granules, under 50 ℃, carry out aeration-drying, make granulate by 20 mesh sieves again, promptly obtain the effervescent Chinese medicinal composition of finished product treatment avian dysentery.
Embodiment 2
A kind of effervescent Chinese medicinal composition for the treatment of avian dysentery, its Chinese medicinal composition and weight are respectively: Radix Scutellariae 8kg, Rhizoma Polygoni Cuspidati 8kg, Radix Pulsatillae 12kg, Radix Sophorae Flavescentis 12kg, Radix Isatidis 15kg, Rhizoma Dryopteris Crassirhizomatis 8kg, Folium Isatidis 7kg, effervescent 10Kg, lubricant 20Kg; Above-mentioned effervescent is made up of citric acid 5Kg and sodium bicarbonate 5Kg, and lubricant is a magnesium stearate.
A kind of effervescent Chinese medicinal composition for the treatment of avian dysentery, the step of its preparation method is:
(1) takes by weighing Radix Scutellariae, Rhizoma Polygoni Cuspidati, the Radix Pulsatillae, Radix Sophorae Flavescentis, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Folium Isatidis extracting in water 2 times according to weight proportion, merging filtrate, being concentrated into relative density under 20 ℃ is 1.35, gets the clear paste drying, pulverize the back all by 100 mesh sieves, obtain mixture A;
(2) take by weighing according to weight proportion that effervescent, lubricant are pulverized respectively and all logical 100 mesh sieves and step (2) in mixture A mix homogeneously, obtain mixture B;
(3) be binding agent system soft material with mixture B with 60% alcoholic solution of %PVP, and with soft material all by 15 mesh sieve system granules, under 60 ℃, carry out aeration-drying, make granulate by 30 mesh sieves again, promptly obtain the effervescent Chinese medicinal composition of finished product treatment avian dysentery.
Embodiment 3
A kind of effervescent Chinese medicinal composition for the treatment of avian dysentery, its Chinese medicinal composition and weight are respectively: Radix Scutellariae 15kg, Rhizoma Polygoni Cuspidati 15kg, Radix Pulsatillae 5kg, Radix Sophorae Flavescentis 5kg, Radix Isatidis 8kg, Rhizoma Dryopteris Crassirhizomatis 11kg, Folium Isatidis 11kg, effervescent 20Kg, the above-mentioned effervescent of lubricant 10Kg are made up of tartaric acid 10Kg and sodium bicarbonate 10Kg, and lubricant is an erythritol.
The step of its preparation method is with embodiment 1.
Embodiment 4
A kind of effervescent Chinese medicinal composition for the treatment of avian dysentery, its Chinese medicinal composition and weight are respectively: Radix Scutellariae 14kg, Rhizoma Polygoni Cuspidati 12kg, Radix Pulsatillae 13kg, Radix Sophorae Flavescentis 8kg, Radix Isatidis 7kg, Rhizoma Dryopteris Crassirhizomatis 6kg, Folium Isatidis 10kg, effervescent 20Kg, lubricant 10Kg; Above-mentioned effervescent is made up of citric acid 10Kg and sodium bicarbonate 10Kg, and lubricant is a magnesium stearate.
The step of its preparation method is with embodiment 1.
Embodiment 5
A kind of effervescent Chinese medicinal composition for the treatment of avian dysentery, its Chinese medicinal composition and weight are respectively: Radix Scutellariae 5kg, Rhizoma Polygoni Cuspidati 15kg, Radix Pulsatillae 5kg, Radix Sophorae Flavescentis 12kg, Radix Isatidis 13kg, Rhizoma Dryopteris Crassirhizomatis 10kg, Folium Isatidis 10kg, effervescent 20Kg, lubricant 10Kg; Above-mentioned effervescent is made up of citric acid 10Kg and sodium bicarbonate 10Kg, and lubricant is a magnesium stearate.
The step of its preparation method is with embodiment 1.
The present invention does not need dissolving in advance in application, directly drop into and culture in the drinking water, and the per kilogram water body gets final product with this Chinese medicine composition 1 gram-10 grams.
The clinical practice experiment
1, experimental technique
At the beginning of 2008, Tianjin certain cultivation base occurrence of large-area dysentery epidemic situation of periphery is cultured the poultry sickness rate up to 50%, and my company is spread for this cultivation base provides the medicine disease controlling, and follows the tracks of the statistics therapeutic outcome.200 of Luo Man egg breed chickens selecting 240 ages in days not fall ill are divided into two groups at random, and one group is adopted common seven granules that relieve internal heat clearly to prevent, and one group is prevented with the present invention; Select 200 of the Luo Man egg breed chickens of 240 ages in days morbidities to be divided into two groups at random, one group is adopted common seven granules that relieve internal heat clearly to treat, and treats with effervescent granule of the present invention for one group.
2, experimental result
The morbidity rehabilitation situation of testing with chicken through the primary part observation record obtains the result, and the experiment of prevention group all is effectively controlled with the chicken incidence, and the state of an illness does not have further spreading trend; Treatment group therapeutic effect is obvious, adopts experimental group of the present invention experiment with 3 of chicken deaths, and cure rate reaches 97%, than adopting the common seven particulate experimental grouies that relieve internal heat clearly to improve 16%.
The characteristic of component among the present invention
1, Radix Scutellariae: heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.Be used for hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, the cough due to lung-heat, the hyperpyrexia excessive thirst, heat in blood is told nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.
2, Rhizoma Polygoni Cuspidati: expelling wind and removing dampness, dissipating blood stasis analgesic therapy, relieving cough and resolving phlegm.Be used for arthralgia, jaundice due to damp-heat, amenorrhea ， WEIJIA, cough with copious phlegm, burn due to hot liquid or fire, injury from falling down, carbuncle sore tumefacting virus.
3, the Radix Pulsatillae: heat-clearing and toxic substances removing
4, Radix Sophorae Flavescentis: heat clearing and damp drying, parasite killing, diuresis.Be used for hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy; External treatment trichomonal vaginitis.
5, Radix Isatidis: maculae caused by violent heat pathogen; The hyperpyrexia headache; Major part pestilence; Crimson tongue is purple dark, scarlet fever; Erysipelas; Mumps; Sore throat; Skin ulcer is swollen, carbuncle; Chickenpox; Measles; Hepatitis; Influenza, epidemic encephalitis, encephalitis b, pneumonia, erysipelas, coma is told nosebleed, pharyngeal swelling, acute catarrhal conjunctivitis, skin ulcer rash; Can prevent and treat epidemic encephalitis type B, acute, chronic hepatitis, mumps, osteomyelitis.
6, Rhizoma Dryopteris Crassirhizomatis: heat-clearing and toxic substances removing, anthelmintic.Be used for abdominal pain due to worm stagnation, skin infection.The hemostasis of Rhizoma Dryopteris Crassirhizomatis charcoal is used for metrorrhagia.
7, Folium Isatidis: staphylococcus aureus, alpha streptococcus, meningococcus, streptococcus pneumoniae, micrococcus catarrhalis, Bacillus typhi, escherichia coli, hemophilus influenza, diphtheria corynebacterium and dysentery bacterium are all had certain inhibitory action, encephalitis b virus, mumps virus, influenza virus etc. are also had inhibitory action.
8, effervescent tablet is a kind of novel tablet of external in recent years Application and Development, the difference of it and conventional tablet, just be that it also contains gas-producing disintegrant, after effervescent tablet is put into water, under the effect of gas-producing disintegrant, produce a large amount of bubbles (carbon dioxide) at once, make rapid disintegrate of tablet and thawing, sometimes the bubble that disintegrate produces also can make tablet roll up and down in water, quickens its disintegrate and thawing.
Claims (4)
1. effervescent Chinese medicinal composition for the treatment of avian dysentery, it is characterized in that: this Chinese medicinal composition and percentage by weight thereof are:
Radix Scutellariae 5-20%; Rhizoma Polygoni Cuspidati 5-20%; Radix Pulsatillae 5-20%;
Radix Sophorae Flavescentis 5-20%; Radix Isatidis 5-20%; Rhizoma Dryopteris Crassirhizomatis 5-20%;
Folium Isatidis 5-20%; Effervescent 10-30%; Lubricant 10-30%.
2. the effervescent Chinese medicinal composition of treatment avian dysentery according to claim 1 is characterized in that: described effervescent is combined by weight 1: 1 by the wherein a kind of and sodium bicarbonate in tartaric acid, citric acid, the adipic acid.
3. the effervescent Chinese medicinal composition of treatment avian dysentery according to claim 1 is characterized in that: described lubricant is wherein a kind of in sucralose, erythritol, magnesium stearate, the dodecyl sodium sulfate.
4. the preparation method of the effervescent Chinese medicinal composition of a treatment avian dysentery as claimed in claim 1, it is characterized in that: the step of preparation method is:
(1) takes by weighing Radix Scutellariae, Rhizoma Polygoni Cuspidati, the Radix Pulsatillae, Radix Sophorae Flavescentis, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Folium Isatidis extracting in water 2 times according to weight proportion, merging filtrate, being concentrated into relative density under 20 ℃ is 1.30～1.35, gets the clear paste drying, pulverize the back all by 80～100 mesh sieves, obtain mixture A;
(2) take by weighing according to weight proportion that effervescent, lubricant are pulverized respectively and all by the mixture A mix homogeneously in 80～100 mesh sieves and the step (2), obtain mixture B;
(3) be binding agent system soft material with mixture B with concentration 50～60% alcoholic solution of 2～4%PVP, and with soft material all by 10～15 mesh sieve system granules, under 50～60 ℃, carry out aeration-drying, make granulate by 20～30 mesh sieves again, promptly obtain the effervescent Chinese medicinal composition of finished product treatment avian dysentery.
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| CN200910228407A CN101816711A (en) | 2009-11-16 | 2009-11-16 | Effervescent Chinese medicinal composition for curing avian dysentery and preparation method thereof |
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| CN200910228407A CN101816711A (en) | 2009-11-16 | 2009-11-16 | Effervescent Chinese medicinal composition for curing avian dysentery and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106214862A (en) * | 2016-08-18 | 2016-12-14 | 山东省农业科学院家禽研究所 | A kind of Traditional Chinese veterinary medicine oral solution preventing and treating the atypical newcastle of chicken and preparation method thereof |
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2009
- 2009-11-16 CN CN200910228407A patent/CN101816711A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106214862A (en) * | 2016-08-18 | 2016-12-14 | 山东省农业科学院家禽研究所 | A kind of Traditional Chinese veterinary medicine oral solution preventing and treating the atypical newcastle of chicken and preparation method thereof |
| CN106214862B (en) * | 2016-08-18 | 2019-10-25 | 山东省农业科学院家禽研究所 | A kind of Traditional Chinese veterinary medicine oral solution and preparation method thereof preventing and treating the atypical newcastle disease of chicken |
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Open date: 20100901 |