CN103751673A - Tibetan medicinal composition for treating diarrhea of yak calf - Google Patents
Tibetan medicinal composition for treating diarrhea of yak calf Download PDFInfo
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- CN103751673A CN103751673A CN201410028836.2A CN201410028836A CN103751673A CN 103751673 A CN103751673 A CN 103751673A CN 201410028836 A CN201410028836 A CN 201410028836A CN 103751673 A CN103751673 A CN 103751673A
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Abstract
The invention discloses a Tibetan medicinal composition for treating diarrhea of yak calf, which is prepared from the following raw materials in parts by weight: 375-420 parts of herb of king corallodiscus, 320-350 parts of phellodendron chinense, 145-160 parts of punica granatum pericarp, and 100 parts of kaempferia galanga. The medicinal composition disclosed by the invention has the characteristics of remarkable therapeutic effect, low adverse side effects, no residue, low cost, convenience in application, and so on, and has a good therapeutic effect on diarrhea in yak calf. Meanwhile, due to the use of traditional Chinese medicinal composition, during the treatment of the disease, the use amount of antibiotics and synthetic drugs in treatment of diarrhea in yak calf can be effectively reduced, the threat on food safety and public health caused by medicinal residues is eliminated, and the social demand for providing safe and pollution-free animal-derived food and human health is fulfilled.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, be specifically related to a kind of Tibetan animal medicinal composition.
Background technology
Yak is the peculiar cattle kind that is grown in high and cold high altitude localities, and China now approximately has more than 1,300 ten thousand, accounts for 92% of world's yak sum, is mainly distributed in the high and cold alpine steppes such as Qinghai, Tibet, Sichuan, Gansu.Yak calf diarrhea is to have a strong impact on calf growth and development, even dead a kind of common frdquently encountered disease, all can occur throughout the year, especially common season with calving in spring, cause that the cause of disease of diarrhoea mainly contains the many factors such as antibacterial, virus, parasite, dyspepsia, account for 89% of calf death.After birth, mostly occur 3 week age with interior new-born calve, morbidity calf clinically main manifestations be appetite decline or useless absolutely, spirit is depressed, feces is shapeless, show as loose stool, watery stool, feces stench, between or be mixed with blood streak bubble, acute a large amount of watery diarrheas, dehydration, self poisoning and heart failure, even dead.Be to cause one of calf retarded growth and harm calf important diseases, bring tremendous economic loss to Tibetan area animal husbandry.
At present, antibiotic is this sick common drug for the treatment of, but long-term a large amount of antibiotic that uses causes pathogenic bacterium drug resistance to produce, and quantity is more and more large, and curative effect is more and more poor.Drug residue also threatens to public health and food safety simultaneously.Therefore, efficient, the safety of development, be difficult for producing drug resistance and low-residual medicine has become the problem that control yak calf diarrhea is needed solution badly.
Summary of the invention
The technical problem to be solved in the present invention is to overcome existing defect, and a kind of Tibetan medicinal composition that uses safe and effective treatment yak calf diarrhea is provided;
Another object of the present invention is to provide the preparation method of the Tibetan medicinal composition of above-mentioned treatment yak calf diarrhea.
Object of the present invention is carried out specific implementation by the following technical programs:
Treat a Tibetan medicinal composition for yak calf diarrhea, its raw material components is as follows:
By weight, 375 ~ 420 parts of Herba Corallodisci Kingianis, 320 ~ 350 parts of Cortex Phellodendris, 145 ~ 160 parts of Pericarpium Granatis, 100 parts of Rhizoma Kaempferiae.
As preferred version, the Tibetan medicinal composition of above-mentioned treatment yak calf diarrhea, its raw material components is as follows:
By weight, 400 parts of Herba Corallodisci Kingianis, 350 parts of Cortex Phellodendris, 150 parts of Pericarpium Granatis, 100 parts of Rhizoma Kaempferiae.
The preparation method of the pharmaceutical composition of above-mentioned treatment yak calf diarrhea, comprises the following steps:
1) according to above-mentioned quality proportioning, take each drug component;
2) each medicine step 1) being taken, decocts with water twice, merges the medicinal liquid of twice decoction, and sterilizing after filtering, is prepared into oral liquid.
Further, described step 2) in, each medicine that step 1) is taken, gets 1000g pharmaceutical composition and is placed in stainless steel cask, adds deionized water 8000ml, decocts, and after boiling, continues to decoct 1 hour, inclines and medicinal liquid; Add again deionized water 5000ml, continue to decoct, after boiling, continue to decoct 1 hour, incline and medicinal liquid; The medicinal liquid that merges twice decoction, after concentrating, is diluted to 1000ml, filters, stir evenly, and subpackage, sterilizing, had both obtained oral liquid.
During use, every each 15ml of yak calf, every day 2 times, is used in conjunction 3 days.
the application of embodiment of the present invention Tibetan medicinal composition and contrast test:
1 materials and methods
1.1 experimental animal
100 of the yak calves of Ruoergai country, Sichuan Province trouble diarrhoea.
1.2 medicine
Contrast medicine: gentamycin sulfate (production of Ruicheng, Shanxi Ya Bao animal pharmaceutical factory);
Test drug: accurately take respectively Herba Corallodisci Kingiani 400g, Cortex Phellodendri 350g, Pericarpium Granati 150g, Rhizoma Kaempferiae 100g, be placed in stainless steel cask, add deionized water 8000ml, decoct, after boiling, continue to decoct 1 hour, incline and medicinal liquid; Add again deionized water 5000ml, continue decoction, after boiling, continue to decoct 1 hour, incline and medicinal liquid, merge the medicinal liquid of twice decoction, be diluted to 1000ml, filter, stir evenly, subpackage, sterilizing, had both obtained test drug oral liquid.
2. test method
Suffer from diarrhoea yak calf for 100, be divided at random two groups, 50 every group, by test drug and control drug, treat respectively.Test drug, each 15ml, every day 2 times, is used in conjunction 3 days.Matched group is gentamycin sulfate, 4mg/kg, and intramuscular injection, every day 2 times, is used in conjunction 3 days.
Efficacy determination: recovery from illness: through treatment, ill yak calf spirit is normal, feces is shaped, neither too hard, nor too soft, color and abnormal smells from the patient normal, clinical symptoms disappears completely, recovers normal.Effective: through treatment, the ill calf mental status takes a turn for the better, and appetite strengthens, and feces character takes a turn for the better, wherein moisture obviously reduces, clinical symptom remission.Invalid: through treatment, ill calf spirit, appetite are without improvement, and feces character is without improvement, aggravation or use other drug treatment instead, even dead.
3. result of the test:
The total effective rate of test drug is 96%, and matched group is 92%, test group and matched group comparison, and test group is greater than or equal to matched group.Illustrate that this medicine has good therapeutical effect to yak calf, the results detailed in Table 1.
The therapeutical effect of table 1 medicine to yak calf diarrhea
Beneficial effect of the present invention:
The pharmaceutical composition of the treatment yak calf diarrhea the invention provides, and its methods for making and using same is provided.Wherein, Herba Corallodisci Kingiani is that tradition is hidden veterinary drug, and Tibetan name is looked into frame and breathed out me, has the effect of heat-clearing and toxic substances removing, cures mainly the diseases such as hot diarrhoea; Cortex Phellodendri is conventional herbal medicine, its cold in nature, bitter in the mouth, and the effects such as tool heat clearing and damp drying, eliminating fire and detoxication, are usually used in the treatment of the diseases such as damp-heat dysentery; Pericarpium Granati has astringing intestine to stop diarrhea effect, conventional treatment chronic diarrhea; And Rhizoma Kaempferiae has warming middle-JIAO for eliminating dampness, promoting the circulation of QI to relieve pain effect, cures mainly acute gastroenteritis, the diseases such as dyspepsia.This pharmaceutical composition is according to pathogenic factor, pathogeny and the clinical symptoms for the treatment of yak calf diarrhea, theoretical according to Traditional Chinese Medicine veterinary and Tibetan veterinary, several herbal medicines combinations of selecting under the prescription foundation of heat clearing and damp drying, relieving diarrhea with astringents, warming middle-JIAO stomach invigorating and control principle prepare, have that clinical efficacy is obvious, side effect is low, noresidue, the feature such as with low cost, easy to use, for yak calf diarrhea, there is good therapeutic effect.Simultaneously, owing to having adopted the form of Chinese medicine composition, in this disease for the treatment of, can effectively reduce or reduce antibiotic, the use amount of chemical synthetic drug in treatment yak calf diarrhea, eliminate drug residue to food safety and sanitarian threat, meet the social need that safety, pollution-free animal-derived food and human health are provided.
The specific embodiment
Below the preferred embodiments of the present invention are described, should be appreciated that preferred embodiment described herein, only for description and interpretation the present invention, is not intended to limit the present invention.
embodiment 1:
Treat a Tibetan medicinal composition for yak calf diarrhea, its raw material components is as follows:
By weight, 400 parts of Herba Corallodisci Kingianis, 350 parts of Cortex Phellodendris, 150 parts of Pericarpium Granatis, 100 parts of Rhizoma Kaempferiae.
Its preparation method is:
1) according to above-mentioned quality proportioning, take each drug component;
2) each medicine step 1) being taken, gets 1000g pharmaceutical composition and is placed in stainless steel cask, adds deionized water 8000ml, decocts, and after boiling, continues to decoct 1 hour, inclines and medicinal liquid; Add again deionized water 5000ml, continue to decoct, after boiling, continue to decoct 1 hour, incline and medicinal liquid; The medicinal liquid that merges twice decoction, after concentrating, is diluted to 1000ml, filters, stir evenly, and subpackage, sterilizing, had both obtained oral liquid.
embodiment 2:
Treat a Tibetan medicinal composition for yak calf diarrhea, its raw material components is as follows:
By weight, 375 parts of Herba Corallodisci Kingianis, 350 parts of Cortex Phellodendris, 145 parts of Pericarpium Granatis, 100 parts of Rhizoma Kaempferiae.
Its preparation method is with embodiment 1.
embodiment 3:
Treat a Tibetan medicinal composition for yak calf diarrhea, its raw material components is as follows:
By weight, 420 parts of Herba Corallodisci Kingianis, 320 parts of Cortex Phellodendris, 160 parts of Pericarpium Granatis, 100 parts of Rhizoma Kaempferiae.
Its preparation method is with embodiment 1.
The foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, although the present invention is had been described in detail with reference to previous embodiment, for a person skilled in the art, its technical scheme that still can record aforementioned each embodiment is modified, or part technical characterictic is wherein equal to replacement.Within the spirit and principles in the present invention all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (4)
1. a Tibetan medicinal composition for the treatment of yak calf diarrhea, is characterized in that: its raw material components is as follows:
By weight, 375 ~ 420 parts of Herba Corallodisci Kingianis, 320 ~ 350 parts of Cortex Phellodendris, 145 ~ 160 parts of Pericarpium Granatis, 100 parts of Rhizoma Kaempferiae.
2. the Tibetan medicinal composition for the treatment of according to claim 1 yak calf diarrhea, is characterized in that: its raw material components is as follows:
By weight, 400 parts of Herba Corallodisci Kingianis, 350 parts of Cortex Phellodendris, 150 parts of Pericarpium Granatis, 100 parts of Rhizoma Kaempferiae.
3. the preparation method of the pharmaceutical composition for the treatment of according to claim 1 and 2 yak calf diarrhea, is characterized in that: comprise the following steps:
1) according to quality proportioning claimed in claim 1, take each drug component;
2) each medicine step 1) being taken, decocts with water twice, merges the medicinal liquid of twice decoction, and sterilizing after filtering, is prepared into oral liquid.
4. the preparation method of the pharmaceutical composition for the treatment of according to claim 3 yak calf diarrhea, it is characterized in that: described step 2), each medicine that step 1) is taken, get 1000g pharmaceutical composition and be placed in stainless steel cask, add deionized water 8000ml, decoct, after boiling, continue to decoct 1 hour, incline and medicinal liquid; Add again deionized water 5000ml, continue to decoct, after boiling, continue to decoct 1 hour, incline and medicinal liquid; The medicinal liquid that merges twice decoction, after concentrating, is diluted to 1000ml, filters, stir evenly, and subpackage, sterilizing, had both obtained oral liquid.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105560444A (en) * | 2016-01-26 | 2016-05-11 | 中国农业科学院兰州畜牧与兽药研究所 | Tibetan drug composition for treating yak gastroenteritis and preparation method and application thereof |
| CN107669982A (en) * | 2017-10-31 | 2018-02-09 | 中国农业科学院兰州畜牧与兽药研究所 | A kind of Tibetan medicinal composition and its preparation method and application |
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| CN101697775A (en) * | 2009-07-24 | 2010-04-28 | 王直军 | Traditional Chinese medicine feed additive for treating animal dysentery and diarrhea |
| CN101757245A (en) * | 2009-10-28 | 2010-06-30 | 张晓波 | Traditional Chinese medicine for treating calf diarrhea |
| CN102940150A (en) * | 2012-12-06 | 2013-02-27 | 山东新希望六和集团有限公司 | Chinese medicament for preventing and treating calf diarrhea and feed |
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- 2014-01-22 CN CN201410028836.2A patent/CN103751673B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101697775A (en) * | 2009-07-24 | 2010-04-28 | 王直军 | Traditional Chinese medicine feed additive for treating animal dysentery and diarrhea |
| CN101757245A (en) * | 2009-10-28 | 2010-06-30 | 张晓波 | Traditional Chinese medicine for treating calf diarrhea |
| CN102940150A (en) * | 2012-12-06 | 2013-02-27 | 山东新希望六和集团有限公司 | Chinese medicament for preventing and treating calf diarrhea and feed |
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| 弋振华等: "《藏兽医经验选编》", 30 November 1979 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105560444A (en) * | 2016-01-26 | 2016-05-11 | 中国农业科学院兰州畜牧与兽药研究所 | Tibetan drug composition for treating yak gastroenteritis and preparation method and application thereof |
| CN105560444B (en) * | 2016-01-26 | 2019-12-17 | 中国农业科学院兰州畜牧与兽药研究所 | Tibetan medicine composition for treating yak gastroenteritis and preparation method and application thereof |
| CN107669982A (en) * | 2017-10-31 | 2018-02-09 | 中国农业科学院兰州畜牧与兽药研究所 | A kind of Tibetan medicinal composition and its preparation method and application |
| CN107669982B (en) * | 2017-10-31 | 2021-03-30 | 中国农业科学院兰州畜牧与兽药研究所 | Tibetan medicine composition and preparation method and application thereof |
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| CN103751673B (en) | 2016-02-24 |
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