CN106309877A - Drug for preventing and treating porcine hemagglutinating encephalomyelitis viruses - Google Patents
Drug for preventing and treating porcine hemagglutinating encephalomyelitis viruses Download PDFInfo
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8888—Pinellia
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
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- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8964—Anemarrhena
Abstract
The invention relates to a drug for preventing and treating porcine hemagglutinating encephalomyelitis viruses and belongs to the technical field of medicine. The drug is used for solving the problem in the treatment of porcine hemagglutinating encephalomyelitis. The drug is characterized by being prepared through combining the following traditional Chinese medicine in parts by mass: 15 parts of cornu bubali, 10 parts of raw rhubarb roots, 9 parts of mirabilite, 12 parts of immature bitter oranges, 8 parts of prepared pinellia tubers, 10 parts of areca catechu, 15 parts of rhizoma anemarrhenae, 15 parts of fructus forsythiae, 15 parts of folium isatidis, 15 parts of mung bean, 4 parts of radix puerariae, 3 parts of flos lonicerae japonicae, 15 parts of radix isatidis, 13 parts of giant typhonium rhizomes and 15 parts of caulis spatholobi.
Description
Technical field
The present invention relates to the medicine of HEV, particularly to the medicine treated with Chinese medicine composition
Thing, belongs to pharmaceutical technology field.
Background technology
Porcine hemagglutinating encephalomyelitis (porcine hemagglutinating encephalomyelitis, PHE) pig
A kind of acute infectious disease, is owing to infecting hemagglutinating encephalomyelitis virus (hemagglutinating
Encephalomyelitis virus, HEV) cause, sick pig mostly is inapparent infection, also has performance digestive system or nerveous system
System symptom, it is possible to use antibiotics is treated, and however it is necessary that to put prevention first.
Porcine hemagglutinating encephalomyelitis is a kind of acute infection caused by the hemagglutinating encephalomyelitis virus of coronavirus genus
Sick.Mainly encroaching on suckling pig, be characterized with vomiting, exhaustion and central nervous system disorder, case fatality rate is the highest.
First porcine hemagglutinating encephalomyelitis is found in Canadian Ontario the latter stage fifties, sends out at that time in piglets
Showing two kinds of diseases that clinical manifestation is different, one is vomitted with unexpected, and continuing to become thin is characterized, referred to as pig vomiting Slim；
Another kind mainly shows as encephalomyelitis symptom, referred to as porcine encephalomyelitis.It is separated to virus the most respectively in two kinds of sick pig bodies.
Proved that both diseases were two kinds of different Clinical types that same coronavirus causes to 1971.Primary disease divides all over the world
Cloth is the widest.China only has minority pig farm the report of morbidity.
Hemagglutinating encephalomyelitis virus (HEV) belongs to coronaviridae coronavirus genus, and virion is spherical, diameter
120nm, has cyst membrane.Genome is single-stranded positive RNA.This virus can be sent out with the erythrocyte of chicken, rat, mice, hamster and turkey
Raw coagulation and adsorption phenomena, to the fatsolvent such as sensitivity such as ether, chloroform and sodium deoxycholate, thermo-labile.
This virus is typically found in upper respiratory tract and the cerebral tissue of pig, therefore sick pig and band poison pig are the important source of infection.
Generally through respiratory tract infection.Majority is to fall ill after introducing new boar, encroaches on a brood of or a few nest suckling pig, Yi Houyou
Create immunoreation in swinery and stop morbidity.This disease only pig infects, and the most susceptible is suckling pig, and bigger pig mostly is
Inapparent infection, and latent infection rate is the highest.
Observing according to clinical manifestation, can be divided into encephalomyelitis type and vomiting Marasmus Malnutrition, both types is simultaneously present in
In one swinery, it is possible to occur different swinerys, or different regions.Encephalomyelitis type betides the son of 4-7 days after birth
Pig, the of short duration rising of body temperature, appetite is useless absolutely before this, occurs drowsiness, vomiting, constipation subsequently.Sick pig dorsal body setae stands upside down, extremity are blue, has
The sick pig sneeze of part, cough, grind one's teeth in sleep.Occur after 1-3 days nervus centralis symptom, instability of gait, lie prone ground, shake or spasm, after
Limb is gradually benumbed.Hyperesthesia, meets the unexpected sound or disturbance just sends and yelps, and last sick pig lies on one's side, and extremity do strokes, exhale
Inhaling difficulty, eye is blind, nystagmus, stupor death.The course of disease about 10 days, case fatality rate reaches more than 98%.
For prevention and the treatment of HEV, there is no effectively preventing medicine and vaccine, main
Rely on the prophylactico-therapeutic measures of strengthening comprehension property, focus on strengthening port quarantine, prevent from introducing disease pig.Once there is this disease, examine in time
Disconnected, strict disinfection and isolation, prevent epidemic situation from spreading diffusion, in order to avoid causing heavy economic losses.Most Prevalent district are in respiratory tract
Subclinical infection state.Sow is many i.e. infects virus the most antenatal, can effectively protect piglet, piglet to be subject to by colostral antibody
It is also at sub-clinical state to when infecting.On newly-built pig farm, sow is antenatal when being uninfected by PEV, and the piglet within 3 week old may go out
Existing clinical symptom.So, maintain the Infection Status of sow that piglet can be avoided to fall ill.Once there is primary disease in piglet, is difficult to nature
Rehabilitation.Should diagnose early, prevent primary disease from spreading expansion.After 2～3 weeks, the piglet of birth can obtain protection by maternal antibody.?
Do not obtain the piglet of maternal antibody before this, hyper-immune serum can be injected after nascent and set up passive immunity.
Summary of the invention
Analyze HEV with tcm theory, belong to spleen kidney deficiency, QI and blood deficiency, attack in pathogenic wind toxic,
Blocking meridians, treatment should be with warming the kidney and strengthening the spleen, benefiting qi and nourishing blood, dispelling pathogenic wind and eliminating phlegm, heat-clearing and toxic substances removing, the medicine combined treatment of promoting blood circulation to remove obstruction in the collateral.
The technical measures that the medicine solution problem of the preventing and treating hemagglutinin cerebrospinal meningitis of pig is taked are by following each Chinese medicine quality
Part ratio combines: Cornu Bubali 15 parts, Radix Et Rhizoma Rhei 10 parts, 9 parts of Natrii Sulfas, Fructus Aurantii Immaturus 12 parts, Rhizoma Pinelliae Preparatum 8 parts, Semen Arecae 10 parts, the Rhizoma Anemarrhenae 15
Part, Fructus Forsythiae 15 parts, Folium Isatidis 15 parts, 15 parts of Semen phaseoli radiati, Radix Puerariae 4 parts, Flos Lonicerae 3 parts, Radix Isatidis 15 parts, Rhizoma Typhonii 13 parts, Sanguis Gallus domesticus
15 parts of rattan.
Cornu Bubali is the succedaneum of Cornu rhinocerotis, is used as medicine with angle, and function cures mainly: clearing away heat and cooling blood, removing toxic substances arresting convulsion；For calentura coma
Delirium, macule, spit blood, epistaxis.Radix Et Rhizoma Rhei have the strongest anti-infectious function, defying age antioxidation, can regulate immunity,
Antiinflammatory, refrigeration function, resisting pathogenic microbes effect, blood fat reducing.Natrii Sulfas is Sulfates mineral Natrii Sulfas race Natrii Sulfas, processed refined
Crystalline solid；Function cures mainly: purging heat to relax the bowels, moistening for dryness and softening hard mass, detumescence of relieving inflammation or internal heat, for excess-heat constipation, constipation due to dry stool, stagnant abdomen
Bitterly, acute appendicitis swells and ache；External treatment acute mastitis, swelling and pain of hemorrhoid.Fructus Aurantii Immaturus is rutaceae Citrus aurantium Linn. and variety thereof or the dry children of Fructus Citri sinensis
Really；Function cures mainly: dispelling the stagnated QI removing food stagnancy, scattered painful abdominal mass of reducing phlegm；Stop in stagnant, feeling of fullness distending pain, weight, constipation, the stagnant gas of expectorant after dysentery
The resistance thoracic obstruction, blocked-up chest；Gastroptosis, proctoptosis, uterine prolapse.Rhizoma Pinelliae Preparatum function cures mainly: drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.Control
Damp-phlegm cold drink, vomiting, regurgitation, cough with asthma abundant expectoration, chest and diaphragm distension, syncope due to accumulation of phlegm headache, dizzy sleeplessness.Semen Arecae effect has expelling phlegm for arresting cough, disappears
The effects such as food relieving alcoholic intoxication, the chest stuffiness relieving emesis, anthelmintic.Effect of the Rhizoma Anemarrhenae and effect: clearing away heat-fire；Nourshing Yin and drynsessmoistening prescription；Quench the thirst relieving restlessness.Main temperature
Calentura；High hot excessive thirst；Cough and asthma；Cough caused by dryness；Constipation；Osteopyrexia and fever；Restlessness of asrhenia type and insomnia；Quench one's thirst stranguria with turbid discharge.Effect of Fructus Forsythiae and effect:
Chinese medicine bitter in the mouth, cold nature, heat-clearing and toxic substances removing, mass dissipating and swelling eliminating, mongolian medicine bitter in the mouth, cool in nature；Cure mainly: calentura from the beginning of, anemopyretic cold, heating,
Vexed, laryngopharynx swelling and pain, macule.Folium Isatidis is as a kind of Chinese medicine, and with a long history, effect is notable.Can be with heat-clearing and toxic substances removing, removing heat from blood disappears
Speckle.Semen phaseoli radiati nature and flavor are sweet cool, have heat-clearing and toxic substances removing, heat-clearing and toxic substances removing, relieve summer heat, effect of diuretic.Radix Puerariae effect: dredging collateral is invigorated blood circulation, blood pressure lowering is only
Dizzy.The principle active component of Radix Puerariae is puerarin, and it has the effect of expansion blood vessel, so energy blood pressure lowering, and improve heart, brain
The blood circulation in portion, the most certain anti thrombotic action.Flos Lonicerae can dispelling wind-heat, be also apt to removing summer-heat blood poison, for each
Planting febrile disease, such as fever of the body, dermexanthesis, send out the cards such as speckle, pyretic toxicity carbuncle sore, laryngopharynx swelling and pain, equal effect is notable.Effect general introduction of Flos Lonicerae:
Heat-clearing and toxic substances removing, wind-heat dissipating.Effect of Radix Isatidis and effect: Radix Isatidis is Isatis indigotica Fort. and the grass root of Folium Isatidis or acanthaceous vegetable acanthaceous indigo
Rhizome and root, effect of Radix Isatidis is heat-clearing and toxic substances removing, blood cooling and ecchymoses removing, relieving sore throat and pain, and the effect of Radix Isatidis is to control influenza, stream
Brain, encephalitis b, pneumonia etc..Effect of Rhizoma Typhonii and effect are dispeled the wind expectorant；The meridian dredging；Removing toxic substances analgesia.In master, wind-phlegm is stopped up；Facial hemiparalysis；
Migraine；Tetanus；Venom；Scrofula tuberculosis；Carbuncle.Dispel the wind expectorant, and arresting convulsion is jerked, detoxicating and resolving stagnation of pathogens pain relieving.Caulis Spatholobi is predominantly
The function of relaxing muscles and tendons to promote blood circulation, also has the effect of certain sterilizing poison.The root of Caulis Spatholobi contains phenolic constituent, aminoacid, saccharide, resin.
Caulis Spatholobi effect: relaxing muscles and tendons to promote blood circulation；Nourishing blood for regulating menstruation, cures mainly: numb hand and foot；Quadriplegia；Rheumatic arthralgia；Women has through uncomfortable.
The drug invention of the preventing and treating hemagglutinin cerebrospinal meningitis of pig provides the benefit that: the preventing and treating hemagglutinin cerebrospinal meningitis of pig
Medicine analyzes HEV with tcm theory, belongs to spleen kidney deficiency, QI and blood deficiency, attacks in pathogenic wind toxic, blocking
Meridians, take to be combined as the medicine of preventing and treating with warming the kidney and strengthening the spleen, benefiting qi and nourishing blood, dispelling pathogenic wind and eliminating phlegm, heat-clearing and toxic substances removing, the medicine of promoting blood circulation to remove obstruction in the collateral
Thing, effect is notable.
Detailed description of the invention
Analyze enforcement consumption and the using method of the medicine of the preventing and treating hemagglutinin cerebrospinal meningitis of pig further below.
The medicine of the preventing and treating hemagglutinin cerebrospinal meningitis of pig is to combine by following each Chinese medicine quality part ratio: Cornu Bubali 15
Part, Radix Et Rhizoma Rhei 10 parts, 9 parts of Natrii Sulfas, Fructus Aurantii Immaturus 12 parts, Rhizoma Pinelliae Preparatum 8 parts, Semen Arecae 10 parts, the Rhizoma Anemarrhenae 15 parts, Fructus Forsythiae 15 parts, Folium Isatidis 15
Part, 15 parts of Semen phaseoli radiati, Radix Puerariae 4 parts, Flos Lonicerae 3 parts, Radix Isatidis 15 parts, Rhizoma Typhonii 13 parts, Caulis Spatholobi 15 parts.By upper drug regimen ratio
Example, the medicinal application of the preventing and treating hemagglutinin cerebrospinal meningitis of pig usage amount in preventing and treating feeding is in following ratio: with 100 jin of pigs
Quality be unit use dose be to combine by following each Chinese medicine quality: Cornu Bubali 15 grams, Radix Et Rhizoma Rhei 10 grams, Natrii Sulfas 9
Gram, Fructus Aurantii Immaturus 12 grams, Rhizoma Pinelliae Preparatum 8 grams, Semen Arecae 10 grams, the Rhizoma Anemarrhenae 15 grams, Fructus Forsythiae 15 grams, Folium Isatidis 15 grams, 15 grams of Semen phaseoli radiati, Radix Puerariae 4 grams,
Flos Lonicerae 3 grams, Radix Isatidis 15 grams, Rhizoma Typhonii 13 grams, Caulis Spatholobi 15 grams.Using method: be ground into medicated powder after each traditional Chinese medicine drying
Material, is directly mixed with medicated powder material in feedstuff and carries out feeding, must stop to feed food more than 24 hours, to strengthen hunger sensation before feeding.
The medicine of the preventing and treating hemagglutinin cerebrospinal meningitis of pig of the present invention is also suitable for other viral swine fever, prevents and treats effective percentage
100%.Treatment cure rate 90%.
Claims (1)
1. prevent and treat the medicine of the hemagglutinin cerebrospinal meningitis of pig, it is characterized in that combining by following each Chinese medicine quality part ratio: Babalus bubalis L.
15 parts of angle, Radix Et Rhizoma Rhei 10 parts, 9 parts of Natrii Sulfas, Fructus Aurantii Immaturus 12 parts, Rhizoma Pinelliae Preparatum 8 parts, Semen Arecae 10 parts, the Rhizoma Anemarrhenae 15 parts, Fructus Forsythiae 15 parts, Folium Isatidis
15 parts of leaf, 15 parts of Semen phaseoli radiati, Radix Puerariae 4 parts, Flos Lonicerae 3 parts, Radix Isatidis 15 parts, Rhizoma Typhonii 13 parts, Caulis Spatholobi 15 parts.
The medicine of the preventing and treating hemagglutinin cerebrospinal meningitis of pig the most according to claim 1, its usage amount being applied to preventing and treating is
In following ratio: the dose used in units of the quality of 100 jin of pigs is to combine by following each Chinese medicine quality: Cornu Bubali
15 grams, Radix Et Rhizoma Rhei 10 grams, 9 grams of Natrii Sulfas, Fructus Aurantii Immaturus 12 grams, Rhizoma Pinelliae Preparatum 8 grams, Semen Arecae 10 grams, the Rhizoma Anemarrhenae 15 grams, Fructus Forsythiae 15 grams, Folium Isatidis
15 grams, 15 grams of Semen phaseoli radiati, Radix Puerariae 4 grams, Flos Lonicerae 3 grams, Radix Isatidis 15 grams, Rhizoma Typhonii 13 grams, Caulis Spatholobi 15 grams.
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| CN201610869326.7A CN106309877A (en) | 2016-09-30 | 2016-09-30 | Drug for preventing and treating porcine hemagglutinating encephalomyelitis viruses |
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| CN201610869326.7A CN106309877A (en) | 2016-09-30 | 2016-09-30 | Drug for preventing and treating porcine hemagglutinating encephalomyelitis viruses |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106798129A (en) * | 2017-03-06 | 2017-06-06 | 长沙瑞多康生物科技有限公司 | A kind of feed of prevention pig transmissible encephalomyelitis |
| CN106889333A (en) * | 2017-03-06 | 2017-06-27 | 长沙瑞多康生物科技有限公司 | A kind of feed of prevention pig transmissible encephalomyelitis |
| CN106901019A (en) * | 2017-03-06 | 2017-06-30 | 长沙瑞多康生物科技有限公司 | A kind of feed of prevention pig transmissible encephalomyelitis |
| CN106912708A (en) * | 2017-03-06 | 2017-07-04 | 长沙瑞多康生物科技有限公司 | A kind of feed of prevention pig transmissible encephalomyelitis |
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| CN101167918A (en) * | 2007-10-25 | 2008-04-30 | 杨成全 | Traditional Chinese medicinal preparation for increasing immunity of pig or poultry |
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| CN104306457A (en) * | 2014-11-18 | 2015-01-28 | 郝建友 | Injection liquid for treating epidemic cerebrospinal meningitis and preparation method thereof |
| CN104840601A (en) * | 2015-04-22 | 2015-08-19 | 日照市畜牧站 | Traditional Chinese medicine preparation for preventing and treating pig epidemic heat diseases |
| CN105456464A (en) * | 2015-12-31 | 2016-04-06 | 张明 | Traditional Chinese medicine composition for treating swine foot-and-mouth disease |
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| CN101167918A (en) * | 2007-10-25 | 2008-04-30 | 杨成全 | Traditional Chinese medicinal preparation for increasing immunity of pig or poultry |
| CN101721602A (en) * | 2008-10-16 | 2010-06-09 | 岳道友 | Animal remedy for treating porcine nameless high-fever syndrome |
| CN102872392A (en) * | 2012-08-31 | 2013-01-16 | 杨高林 | Chinese medicinal preparation for preventing and controlling swine mycoplasma pneumonia and preparation method thereof |
| CN104306457A (en) * | 2014-11-18 | 2015-01-28 | 郝建友 | Injection liquid for treating epidemic cerebrospinal meningitis and preparation method thereof |
| CN104840601A (en) * | 2015-04-22 | 2015-08-19 | 日照市畜牧站 | Traditional Chinese medicine preparation for preventing and treating pig epidemic heat diseases |
| CN105456464A (en) * | 2015-12-31 | 2016-04-06 | 张明 | Traditional Chinese medicine composition for treating swine foot-and-mouth disease |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106798129A (en) * | 2017-03-06 | 2017-06-06 | 长沙瑞多康生物科技有限公司 | A kind of feed of prevention pig transmissible encephalomyelitis |
| CN106889333A (en) * | 2017-03-06 | 2017-06-27 | 长沙瑞多康生物科技有限公司 | A kind of feed of prevention pig transmissible encephalomyelitis |
| CN106901019A (en) * | 2017-03-06 | 2017-06-30 | 长沙瑞多康生物科技有限公司 | A kind of feed of prevention pig transmissible encephalomyelitis |
| CN106912708A (en) * | 2017-03-06 | 2017-07-04 | 长沙瑞多康生物科技有限公司 | A kind of feed of prevention pig transmissible encephalomyelitis |
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