CN105560444A - Tibetan drug composition for treating yak gastroenteritis and preparation method and application thereof - Google Patents
Tibetan drug composition for treating yak gastroenteritis and preparation method and application thereof Download PDFInfo
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- 208000005577 Gastroenteritis Diseases 0.000 title claims abstract description 31
- 229940079593 drug Drugs 0.000 title claims abstract description 27
- 239000000203 mixture Substances 0.000 title claims abstract description 26
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 244000304337 Cuminum cyminum Species 0.000 claims abstract description 7
- 235000007129 Cuminum cyminum Nutrition 0.000 claims abstract description 7
- 239000007788 liquid Substances 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 206010012735 Diarrhoea Diseases 0.000 claims description 8
- 241000903946 Clematidis Species 0.000 claims description 6
- 244000292697 Polygonum aviculare Species 0.000 claims description 6
- 235000006386 Polygonum aviculare Nutrition 0.000 claims description 6
- 241000220324 Pyrus Species 0.000 claims description 6
- 238000009835 boiling Methods 0.000 claims description 6
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- 229910021641 deionized water Inorganic materials 0.000 claims description 6
- 235000021017 pears Nutrition 0.000 claims description 6
- 230000001954 sterilising effect Effects 0.000 claims description 5
- 244000309466 calf Species 0.000 claims description 3
- 229910001220 stainless steel Inorganic materials 0.000 claims description 3
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- 230000005180 public health Effects 0.000 abstract description 2
- 239000000126 substance Substances 0.000 abstract description 2
- 241000601186 Clematis tangutica Species 0.000 abstract 1
- 241000501717 Gentiana urnula Species 0.000 abstract 1
- 241001558443 Koenigia divaricata Species 0.000 abstract 1
- 244000061839 Pyrus pashia Species 0.000 abstract 1
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- 238000012360 testing method Methods 0.000 description 17
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/51—Gentianaceae (Gentian family)
- A61K36/515—Gentiana
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/716—Clematis (leather flower)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The invention provides a Tibetan drug composition for treating yak gastroenteritis. The Tibetan drug composition is prepared from, by weight, 200 parts of polygonum divaricatum, 180 parts of gentiana urnula, 180 parts of radix pleurospermi tibetanici, 180 parts of cumin, 160 parts of clematis tangutica and 100 parts of pyrus pashia. The invention further provides a preparation method and application of the Tibetan drug composition. The Tibetan drug composition has the advantages of being obvious in clinical treatment effect, low in side effect, free of residues, low in cost, convenient to use and the like, and has a good treatment effect on yak gastroenteritis. The use amount of antibiotics and chemical synthetic drugs in treating yak gastroenteritis can be effectively reduced through use of the composition, threats of drug residues to food safety and public health are eliminated, and social requirements for providing safe and pollution-free animal-derived food and on human health are met.
Description
Technical field
The invention belongs to Tibetan medicine technical field, be specifically related to a kind ofly be used for the treatment of Tibetan medicinal composition of yak gastroenteritis and its preparation method and application.
Background technology
Yak is the peculiar cattle kind of growth in high altitudes and cold area, and China now about has more than 1,300 ten thousand, accounts for more than 92% of world's yak sum, is mainly distributed in the high and cold high altitude grassland such as Qinghai, Tibet, Sichuan, Gansu.Yak gastroenteritis is the common multiple disease of yak, and due to spring and autumn climate variability, alternation of chills and fever, yak gastroenteritis has generation more, often because gastroenteritis causes death.The yak that mostly is of this disease searches for food and mouldly loses unclean forage or drink filthy muddy water, weather change suddenly cold or hot caused by.Hide veterinary to think, gastroenteritis to be invaded in the heresy due to wet, heat, cold, summer-heat or thing that internal injury diet is sombrely unclean causes, and damp and hot tenesmus or cold-damp bet stop a kind of acute inflammation amassed in stomach or intestinal, and Tibetan language is named " race Cai Jicai ".Ill yak main manifestations spiritedness is depressed clinically, poor appetite or useless temperature pulse respiration increases absolutely, the sick just high Sheng of borborygmus, and middle and late stage weakens, loose and watery stool like water sample, foul smelling taste; Have stomachache phenomenon, ill domestic animal later turns round and look at abdomen, time sleeping when rising, the rubescent or crimson band Huang of mouth color, yellow fur is thick or yellow greasy; Severe patient has dewatering symptom to occur, even dead.This disease is one of harm yak important diseases, brings tremendous economic to lose to Tibetan area animal husbandry.
At present, antibiotic is the common drug of this disease for the treatment of, but long-term a large amount of antibiotic that uses causes pathogenic bacterium drug resistance to produce, and quantity is more and more large, and curative effect is more and more poor.Drug residue also threatens to public health and food safety simultaneously.Therefore, development is efficient, generation drug resistance and low-residual medicine have become the problem that control yak gastroenteritis needs solution badly safely, not easily.
Summary of the invention
In order to solve problems of the prior art, the invention provides a kind of Tibetan medicinal composition being used for the treatment of yak gastroenteritis, this Tibetan medicinal composition use safety, not easily generation drug resistance and low-residual, good drug efficacy; For this reason, the present invention also provides the preparation method and application of this Tibetan medicinal composition.
First object of the present invention is to provide a kind of Tibetan medicinal composition being used for the treatment of yak gastroenteritis, by weight, each crude drug component is: fork point knotweed 200 parts, Herba Gentianae Urnulae 180 parts, Herba pleurospermi thomsonii 180 parts, Cuminum cyminum L 180 parts, Herba Clematidis tanguticae 160 parts, river pears 100 parts.
Second object of the present invention is to provide the preparation method of above-mentioned Tibetan medicinal composition, by each crude drug mixing of formula ratio, decocts with water 1-3 time, after merging medicinal liquid, filters and sterilizing, to obtain final product.
As preferably, preparation method is: take fork point knotweed 200 parts, Herba Gentianae Urnulae 180 parts, Herba pleurospermi thomsonii 180 parts, Cuminum cyminum L 180 parts, Herba Clematidis tanguticae 160 parts, river pears 100 parts, be placed in stainless steel cask, add deionized water 8000ml, decoct, after boiling, continue decoction 1 hour, incline and medicinal liquid; Add deionized water 5000ml again, continue to decoct, after boiling, continue decoction 1 hour, incline and medicinal liquid, merge the medicinal liquid of twice decoction, be diluted to 1000ml, filter, stir evenly, subpackage, sterilizing, obtain oral liquid.
3rd object of the present invention is to provide the application of above-mentioned Tibetan medicinal composition in the medicine of preparation treatment yak gastroenteritis.
With Tibetan medicinal composition of the present invention for effective ingredient can be prepared into the medicine of multiple dosage form, be prepared with reference to existing method in prior art.Because containing Tibetan medicinal composition of the present invention, therefore all there is certain therapeutic effect to yak gastroenteritis.
The invention provides the Tibetan medicinal composition being used for the treatment of yak gastroenteritis, and provide its preparation method and application.Six medicaments is traditional Tibetan medicine, and the effect of each crude drug is as follows:
A fork point knotweed, hides name Ni Aluo, bitter in the mouth, acid, puckery, has clearing away heat to stop diarrhea.Cure mainly the disease such as gastritis, large and small intestinal accumulated heat.
Herba Gentianae Urnulae: Zang Ming hilllock loud, high-pitched sound is poor, bitter in the mouth is cool in nature, has heat-clearing and toxic substances removing, effect of antidiarrheal.Cure mainly gastroenteritic ulcer, the diseases such as hot diarrhoea.
Herba pleurospermi thomsonii: hide name Jia Wa, sweet in the mouth, pungent, bitter, hot in nature, the effect of have stomach invigorating, dispeling cold; Cure mainly dyspepsia, " dragon " is sick.
Cuminum cyminum L, hides name Si La Ga and protects, and is acrid in the mouth, sweet, has lifting stomach-fire, help digestion, effect of warming middle-JIAO, cure mainly cold syndrome of the stomach abdominal distention, the diseases such as dyspepsia.
Herba Clematidis tanguticae, hide name and also cover, sweet in the mouth, hardship, property is put down, and enters taste two warp, has the effect such as consumer product dredge stasis, removing toxic substances and promoting pus discharge, cure mainly the disease such as dyspepsia, diarrhoea.
River pears: hide name Zha Baxingluomanie buy, sour in the mouth, sweet, warm in nature, have help digestion long-pending, effect that blood stasis dispelling is stagnant; Cure mainly dyspepsia, the disease such as to have loose bowels.
Tibetan medicinal composition of the present invention is pathogenic factor, pathogeny and clinical symptoms according to yak gastroenteritis, according to Traditional Chinese Medicine veterinary and Tibetan veterinary's theory, under the prescription foundation and control principle of heat-clearing and toxic substances removing, warming spleen and stomach for dispelling cold, relieving diarrhea with astringents, the combination of a few herbal medicine is selected to prepare, have that clinical efficacy is obvious, side effect is low, noresidue, the feature such as with low cost, easy to use, for yak gastroenteritis, there is good therapeutic effect.Simultaneously, owing to have employed the form of Chinese medicine composition, when treating this disease, can effectively reduce or reduce antibiotic, the use amount of chemical synthetic drug in treatment yak gastroenteritis, eliminate drug residue to food safety and sanitarian threat, meet the social need that safety, free of contamination animal-derived food and human health are provided.
Detailed description of the invention
Following embodiment is convenient to understand the present invention better, but does not limit the present invention.Experimental technique in following embodiment, if no special instructions, is conventional method.Test material used in following embodiment, if no special instructions, is commercially available.
Embodiment 1
A kind of component being used for the treatment of the Tibetan medicinal composition of yak gastroenteritis of the present invention is:
Fork point knotweed 200g, Herba Gentianae Urnulae 180g, Herba pleurospermi thomsonii 180g, Cuminum cyminum L 180g, Herba Clematidis tanguticae 160g, river pears 100g.
A kind of preparation method being used for the treatment of the Tibetan medicinal composition of yak gastroenteritis of the present invention is:
1) each drug component is taken according to above-mentioned mass fraction;
2) pharmaceutical composition that step 1) takes is placed in stainless steel cask, adds the deionized water of 8 times of quality, decoct, after boiling, continue decoction 1 hour, incline and medicinal liquid; Add the deionized water of 5 times of quality again, continue to decoct, after boiling, continue decoction 1 hour, incline and medicinal liquid; Merge the medicinal liquid of twice decoction, be diluted to 1000ml, filter, stir evenly, subpackage, sterilizing, obtain oral liquid.
Oral liquid of the present invention has good therapeutic effect to yak gastroenteritis, and cure rate is more than 80%, and total effective rate is more than 90%.The present invention will be further elaborated below will to provide embody rule embodiment.
The application of embodiment 2 Tibetan medicinal composition of the present invention and contrast test 1
1 materials and methods
1.1 experimental animal
The yak 100 of gastroenteritis is suffered from Ruoergai country, Sichuan Province.
1.2 medicine
Test drug: medicine of the present invention;
Contrast medicine: ciprofloxacin (Guangdong Dahuanong Animal Health Products Co., Ltd.'s production).
2. test method
Suffer from gastroenteritis yak, be divided into two groups at random for 100, often organize 50, treat by test drug and control drug respectively.Test drug, oral, each 200ml, every day 2 times, is used in conjunction 3 days.Matched group is ciprofloxacin, 2mg/kg, intramuscular injection, every day 2 times, is used in conjunction 3 days.
Efficacy determination: recovery from illness: through treatment, ill yak spirit is normal, and formed stools, neither too hard, nor too soft, color and abnormal smells from the patient are normal, and clinical symptoms disappears completely, recovers normal.Effective: through treatment, the ill yak mental status takes a turn for the better, and appetite strengthens, and feces character takes a turn for the better, clinical symptom remission.Invalid: through treatment, ill yak spirit, appetite are without improvement, and feces character is without improvement, aggravation or use other drug treatment instead, even dead.
3. result of the test:
Test drug is consistent with contrast medicine to the total effective rate of yak gastroenteritis, and be 94%, but the cure rate of test drug is 86%, matched group is 82%, and test group compares with matched group, and test group is greater than or equal to matched group.Illustrate that this medicine has good therapeutical effect, the results detailed in Table 1 to yak gastroenteritis.
Table 1 different pharmaceutical is to the therapeutical effect of diarrhea of yak calf
The application of embodiment 3 Tibetan medicinal composition of the present invention and contrast test 2
1 materials and methods
1.1 experimental animal
The yak 100 of gastroenteritis is suffered from Maqu County county of Gansu Province.
1.2 medicine
Test drug: medicine of the present invention;
Contrast medicine: poplar flower oral liquid (the generous biological engineering company limited in Nanjing produces).
2. test method
Suffer from gastroenteritis yak, be divided into two groups at random for 100, often organize 50, treat by test drug and control drug respectively.Test drug, oral, each 200ml, every day 2 times, is used in conjunction 3 days.Matched group is poplar flower oral liquid, each 100ml, every day 2 times, is used in conjunction 3 days.
Efficacy determination: recovery from illness: through treatment, ill yak spirit is normal, and formed stools, neither too hard, nor too soft, color and abnormal smells from the patient are normal, and clinical symptoms disappears completely, recovers normal.Effective: through treatment, the ill yak mental status takes a turn for the better, and appetite strengthens, and feces character takes a turn for the better, clinical symptom remission.Invalid: through treatment, ill yak spirit, appetite are without improvement, and feces character is without improvement, aggravation or use other drug treatment instead, even dead.
3. result of the test:
Test group compares with matched group, and the cure rate of test group and effective percentage are all higher than matched group.Illustrate that this medicine has good therapeutical effect, the results detailed in Table 2 to yak gastroenteritis.
Table 2 different pharmaceutical is to the therapeutical effect of diarrhea of yak calf
。
Last it is noted that the foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (4)
1. one kind is used for the treatment of the Tibetan medicinal composition of yak gastroenteritis, it is characterized in that: by weight, each crude drug component is: fork point knotweed 200 parts, Herba Gentianae Urnulae 180 parts, Herba pleurospermi thomsonii 180 parts, Cuminum cyminum L 180 parts, Herba Clematidis tanguticae 160 parts, river pears 100 parts.
2. the preparation method of Tibetan medicinal composition according to claim 1, is characterized in that: by each crude drug mixing of formula ratio, decoct with water 1-3 time, merge medicinal liquid, sterilizing after filtering, is prepared into oral liquid.
3. a kind of preparation method for the treatment of the pharmaceutical composition of diarrhea of yak calf according to claim 2, it is characterized in that, take fork point knotweed 200 parts, Herba Gentianae Urnulae 180 parts, Herba pleurospermi thomsonii 180 parts, Cuminum cyminum L 180 parts, Herba Clematidis tanguticae 160 parts, river pears 100 parts, be placed in stainless steel cask, add deionized water 8000ml, decoct, after boiling, continue decoction 1 hour, incline and medicinal liquid; Add deionized water 5000ml again, continue to decoct, after boiling, continue decoction 1 hour, incline and medicinal liquid, merge the medicinal liquid of twice decoction, be diluted to 1000ml, filter, stir evenly, subpackage, sterilizing, obtain oral liquid.
4. the application of Tibetan medicinal composition according to claim 1 in the medicine of preparation treatment yak gastroenteritis.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107669982A (en) * | 2017-10-31 | 2018-02-09 | 中国农业科学院兰州畜牧与兽药研究所 | A kind of Tibetan medicinal composition and its preparation method and application |
| CN107823536A (en) * | 2017-11-07 | 2018-03-23 | 西藏自治区农牧科学院畜牧兽医研究所 | It is a kind of to be used to prevent and treat Tibetan medicinal composition of hueppe's disease caused by pasteurella multocida and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107669982A (en) * | 2017-10-31 | 2018-02-09 | 中国农业科学院兰州畜牧与兽药研究所 | A kind of Tibetan medicinal composition and its preparation method and application |
| CN107669982B (en) * | 2017-10-31 | 2021-03-30 | 中国农业科学院兰州畜牧与兽药研究所 | Tibetan medicine composition and preparation method and application thereof |
| CN107823536A (en) * | 2017-11-07 | 2018-03-23 | 西藏自治区农牧科学院畜牧兽医研究所 | It is a kind of to be used to prevent and treat Tibetan medicinal composition of hueppe's disease caused by pasteurella multocida and preparation method thereof |
| CN107823536B (en) * | 2017-11-07 | 2021-02-09 | 西藏自治区农牧科学院畜牧兽医研究所 | Tibetan medicine composition for preventing and treating hemorrhagic septicemia caused by Pasteurella multocida and preparation method thereof |
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| CN105560444B (en) | 2019-12-17 |
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