CN103341066B - Chinese medicine oral liquid for treating hand-foot-mouth diseases of children and preparation method thereof - Google Patents
Chinese medicine oral liquid for treating hand-foot-mouth diseases of children and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a Chinese medicine oral liquid for treating hand-foot-mouth diseases of children and a preparation method thereof. The Chinese medicine oral liquid comprises the following Chinese medicine raw materials in parts by weight: 12-18 parts of gypsum, 1-5 parts of isatis root, 1-5 parts of rhizoma cimicifugae, 1-5 parts of agastache rugosus, 3-8 parts of dandelion, 1-5 parts of coptis, 7-12 parts of lalang grass rhizome, 1-5 parts of cortex moutan, 7-13 parts of mung bean and 8-14 parts of uncaria. The Chinese medicine oral liquid disclosed by the invention can be used for treating fever and herpes, has the effects of promoting the healing of oral ulcer, preventing neurological complications and the like and has the advantages of very good curative effect on regression of rash, no toxic or side effect, remarkable curative effect on ordinary type hand-foot-mouth diseases of children, benefit of the recovery of body temperature, the drying and the incrustation of herpes and the like and capability of rapidly abating fever and obviously reducing the probability that the sick children are turned into severe cases.
Description
Technical field
The present invention relates to hand-foot-mouth disease Chinese medicine oral liquid technical field.
Background technology
Hand-foot-mouth disease (hand foot and mouth disease, HFMD) mainly by comprise enterovirns type 71 and Coxsackie virus 16 type etc. infect caused by with heating, the position erythra such as hands, foot, oral cavity is child's infectious disease of main manifestations, be common in less than 5 years old child, can cause the herpes at the positions such as hands, foot and oral cavity, can there is the complication that myocarditis, pulmonary edema, aseptic meningitis etc. are serious in minority infant.If indivedual serious symptom person's PD is fast, often cause death.Chinese medicine is thought, hand-foot-mouth disease disease belongs to the category such as the traditional Chinese medical science " pathogenic wind-warm ", " hygropyrexia ", " epidemic disease ", and its cause of disease is for experiencing epidemic disease poison seasonal pathogen, and sick position is mainly dirty at lung, spleen, the heart three.Children's's the spleen tending to insufficiency usually, lungs are tender and lovely, subject to damage.Epidemic disease poison seasonal pathogen is entered by mouth and nose, inside invades lung spleen, and defend table and held back, Lung Qi obstraction, be then shown in heating, headache, cough, watery nasal discharge etc.; Evil poison follow through, stifling dispute, then herpes of mouth, stomatalgia, refusing to eat, sialorrhea, pathogenic heat fumigate extremity, then brothers' herpes; If scorchingly hot interior Sheng, intense heat in both QI and YING systems, then the distribution of extremity buttocks herpes is dense, and symptom is very grave; If evil malicious the pathogen attacking the pericardium adversely, cave in the moon of fainting, and can occur the crisis such as high fever, coma, tic.
Tcm clinical practice is according to the theory of curing the disease of determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs and organic conception, plain edition Hand-Food-Mouth Disease is divided into following 6 kinds of pattern of syndrome: evil lung of violating defends type, and disease sees that heating is slight, or without heating, micro evil wind is trembled with fear, sweating is not smooth or lossless, or slight cough, watery nasal discharge, brothers' macule is indistinctly or without macule, rarely seenly pharyngeally be dispersed in herpes, pharyngalgia, the white or BOHUANG of red tongue with thin fur, floating and rapid pulse.Method for the treatment of is with the pungent table that cools completely, and heat-clearing and toxic substances removing is main.The vehement type of lung gastric heat, disease sees high fever flushed complexion, and profuse perspiration is thirsty, and maculopapule or herpes appear in hands, foot, oral cavity and buttocks, and the light red matter profit of rash color, bleb liquid is limpid, constipation, and red tongue with yellow fur is dry, and rapid pulse is strong.Method for the treatment of is with removing heat from QI system with drugs of pungent flavor and cold nature, and the removing toxic substances that expels the heat-evil is main.Intense heat in both QI and YING systems type, disease sees high fever flushed complexion, vexed restlessness, and the visible a large amount of maculopapule of hands, foot, oral cavity and buttocks or herpes, rash red complexion is purple, is bordering between macule, can merge in flakes, and the muddy color of herpes liquid is red, deep red tongue dry, rough and yellow fur, rapid pulse.Method for the treatment of is with clearing heat in YING system, and removing heat from blood, removing toxic substances is main.Damp and hot interlocking type, disease sees low thermal fluctuation, poor appetite, and feel sick, vomiting is had loose bowels, and herpes color and luster is purple dark, distributes dense, or cluster occurs, bleb liquid is muddy, can with pruritus, red tongue, thick, yellow and greasy fur or BOHUANG greasy, slippery and rapid pulse.Method for the treatment of is with removing damp and turbid, and heat-clearing and toxic substances removing is main.Accumulation of heat in the heart and spleen type, disease sees that heating is slight, or without heating, based on herpes in oral cavity, forms ulcer after diabrosis, pain sialorrhea, not for feed.Restlessness and thirst, meaning desire for cold-drinking, the lips are dry and the mouth is parched, and stuck out one's tongue frequent protrusion of the tongue, and dry stool is urinated red, red tip of the tongue, thin fur or BOHUANG, rapid pulse.Method for the treatment of is with the purgation of spleen excess that clears away heart-fire, and pathogenic fire reducing removing toxic substances is main.Lung stomach-Yin hinders type, and disease sees rash acetaminophen, dry mouth and throat, or the few expectorant of dry cough, and expectoration is not well, lack of appetite poor appetite, feverish sensation in the palms and soles, the few tongue of red tongue or no fur, deficient and rapid pulse.Method for the treatment of is with nourishing YIN and clearing away lung-heat, and regulating the stomach and sending down the abnormal ascending QI is main.
Child is the Susceptible population of infectious disease, and resistivity is comparatively weak, children is also comparatively special, current doctor trained in Western medicine there is no the specific drug for treatment Hand-Food-Mouth Disease clinically, mostly give antiviral drugs and this disease of antibiotic therapy, but because the range of choice of this type of medicine is wide, immunotherapy targeted autoantibody is poor, cause child patient easily to occur toxic and side effects and the drug resistance of medicine, thus lessen the curative effect, delay the course of disease.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of Chinese medicine oral liquid for the treatment of Hand-Food-Mouth Disease and preparation method thereof, and Chinese medicine oral liquid of the present invention can be brought down a fever fast, has good curative effect to disappearing of erythra, can be used for treatment heating, herpes.The effect such as the healing of oral ulcer, prevention neurological complication can be promoted simultaneously, Chinese medicine of the present invention has no side effect, there is significant curative effect for plain edition Hand-Food-Mouth Disease, and be conducive to the recovery, herpes drying, incrustation etc. of body temperature, obviously can reduce the probability that infant transforms to serious symptom.
For solving the problems of the technologies described above, the technical solution used in the present invention is: a kind of Chinese medicine oral liquid for the treatment of Hand-Food-Mouth Disease, is made up of the raw material of Chinese medicine of following weight parts: Gypsum Fibrosum 12 ~ 18, Radix Isatidis 1 ~ 5, Rhizoma Cimicifugae 1 ~ 5, Herba Pogostemonis 1 ~ 5, Herba Taraxaci 3 ~ 8, Rhizoma Coptidis 1 ~ 5, Rhizoma Imperatae 7 ~ 12, Cortex Moutan 1 ~ 5, Semen phaseoli radiati 7 ~ 13, Ramulus Uncariae Cum Uncis 8 ~ 14.
Preferably be made up of the raw material of Chinese medicine of following weight parts: Gypsum Fibrosum 14 ~ 17, Radix Isatidis 2 ~ 5, Rhizoma Cimicifugae 2 ~ 5, Herba Pogostemonis 2 ~ 5, Herba Taraxaci 5 ~ 8, Rhizoma Coptidis 1 ~ 3, Rhizoma Imperatae 8 ~ 11, Cortex Moutan 2 ~ 4, Semen phaseoli radiati 9 ~ 13, Ramulus Uncariae Cum Uncis 10 ~ 13.
The preferred raw material of Chinese medicine by following weight parts forms: Gypsum Fibrosum 16, Radix Isatidis 4, Rhizoma Cimicifugae 4, Herba Pogostemonis 4, Herba Taraxaci 7, Rhizoma Coptidis 1, Rhizoma Imperatae 9, Cortex Moutan 3, Semen phaseoli radiati 11, Ramulus Uncariae Cum Uncis 12.
The preparation method of the Chinese medicine oral liquid for the treatment of Hand-Food-Mouth Disease, comprises the following steps:
(1) take raw material of Chinese medicine according to weight proportion, first time adds 8 ~ 12 times of water gagings, decocts 1 ~ 2 hour, and second time adds 6 ~ 7 times of water gagings, decocts 1 ~ 2 hour, merges twice decoction liquor;
(2) relative density of putting in vacuum concentrator when being concentrated into 45 DEG C is 1.05 ~ 1.15;
(3) concentrated solution step (2) obtained is centrifugal, revolution 16000-20000r/min, filters;
(4) sterilizing.
The sodium benzoate antiseptic of appropriate simple syrup (sugar content is 30%) and 0.2% can be added in filtrate in step (3).
Adopt Arnold steam sterilizor sterilization in step (4), parameter is 100 DEG C, 30min.
In preferred step (1), first time adds 10 times of water gagings, decocts 1.5 hours, and second time adds 6 times of water gagings, decocts 1 hour.
In step (2), during vacuum concentration, temperature is below 60 DEG C, and vacuum is 0.08Mpa.
Crude drug source selected by the present invention is as follows:
Gypsum Fibrosum is Sulfates mineral anhydrite race Gypsum Fibrosum.
Radix Isatidis is crucifer ancient name for Chinese cabbage
blue Isatis indigoticafort. dry root.
Rhizoma Cimicifugae is ranunculaceae plant C.heracleifolia
cimicifuga heracleifoliakom., Cimicifuga Dahurica
cimicifuga dahurica(Turcz.) Maxim. or Rhizoma Cimicifugae
cimicifuga foetidal. dry rhizome.
Herba Pogostemonis is labiate Herba Pogostemonis
pogostemon cablin(Blanco) dry aerial parts of Benth..
Herba Taraxaci is feverfew Herba Taraxaci
taraxacum mongolicumhand.Mazz., alkali ground Herba Taraxaci
taraxacum borealisinenseor belong to the dry herb of several plants together Kitam..
Rhizoma Coptidis is ranunculaceae plant Rhizoma Coptidis
coptis chinensisfranch., Coptis deltoidea C.Y.Cheng et Hsiao
coptis deltoideac.Y.Cheng et Hsiao or Coptis Teeta Wall
coptis teetawall. dry rhizome.
Rhizoma Imperatae is grass Herba Imperatae
imperata cylindricabeauv.
major(Nees) dry rhizome of C.E.Hubb..
Cortex Moutan is ranunculaceae peony
paeonia suffruticosaandr. dry root bark.
Semen phaseoli radiati is leguminous plant Semen phaseoli radiati
phaseolus radiatusl. dry seed.
Ramulus Uncariae Cum Uncis is Maguireothamnus speciosus Ramulus Uncariae Cum Uncis
uncaria rhynchophylla(Miq.) Miq.ex Havil., Ramulus Uncariae macrophyllae Uncaria macrophylla Wall., Ramulus Uncariae Cum Uncis
uncaria hirsutahavil., Uncaria sinensis (Oliv.) Havil.
uncaria sinensis(Oliv.) Havil. or stockless fruit Ramulus Uncariae Cum Uncis
uncaria sessilifructusroxb. dry stem and branch with belt hook.
Prescription side of the present invention separates as follows:
Gypsum Fibrosum: the heat that clear eliminating the pathogens from the lung gastric qi is divided.
Radix Isatidis: separate pestilence seasonal noxious pathogen.
Rhizoma Cimicifugae: deliver rash, heat-clearing and toxic substances removing, elevate a turnable ladder yang-energy.
Herba Pogostemonis: with in, ward off dirty, damp eliminating.
Herba Taraxaci: heat-clearing and toxic substances removing eliminating carbuncle eliminating stagnation.
Rhizoma Coptidis: heat clearing and damp drying, eliminating fire and detoxication.
Rhizoma Imperatae: removing heat from blood, hemostasis, heat clearing away, diuresis.
Cortex Moutan: clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.
Ramulus Uncariae Cum Uncis: dispelling wind and relieving convulsion, heat clearing away suppressing the hyperactive liver.
Monarch drug: Gypsum Fibrosum: the heat that clear eliminating the pathogens from the lung gastric qi is divided; Ministerial drug: Radix Isatidis, separates pestilence seasonal noxious pathogen; Rhizoma Cimicifugae, delivers rash, heat-clearing and toxic substances removing, elevate a turnable ladder yang-energy; Herba Pogostemonis, and in, ward off dirty, damp eliminating; Adjuvant: Herba Taraxaci, heat-clearing and toxic substances removing eliminating carbuncle eliminating stagnation; Rhizoma Coptidis, heat clearing and damp drying, eliminating fire and detoxication; Cortex Moutan: clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling; Rhizoma Imperatae, Semen phaseoli radiati, Ramulus Uncariae Cum Uncis, clearing away heat and cooling blood suppressing the hyperactive liver to relieve the wind syndrome.Perfect square is mainly used in the plain edition Hand-Food-Mouth Disease that various heat symptom-complex causes.There is significant curative effect the aspect such as symptom, sign such as herpes and (or) erythra, cough, poor appetite for the position such as heating, hand-foot-mouth disease of infant.
Children's's hand-foot-mouth disease cardinal symptom is high heat, twitches and hand-foot-mouth disease herpes.What we's consumption was maximum is Gypsum Fibrosum, and this product is the product in large bitter Great Cold, returns lung stomach warp, have effect that sore is brought down a fever, can treat the symptom of ulcer and unconsciousness due to high fever, it is intended to bring down a fever for elder generation, the harm of the nervous system avoiding Yin Gaore to cause and even more serious complication, affect intelligent development.Secondly be Ramulus Uncariae Cum Uncis, this product bitter cold, returns liver, heart channel, has heat clearing away suppressing the hyperactive liver, effect of relieving spasm by subduing liver-wind.Twitch for the second largest feature of children's's hand-foot-mouth disease disease, analyze from traditional Chinese medical science Point of View of Clinical, this symptom belongs to liver, the classical symptom of heart channel, the special efficacy of Ramulus Uncariae Cum Uncis relieving spasm by subduing liver-wind, can be good at treatment infantile convulsion and night cry.Common effect of Radix Isatidis, Herba Taraxaci and Rhizoma Coptidis is clearing away damp-heat, relieving heat toxin.Evil poison follow through, stifling dispute, then herpes of mouth, stomatalgia, refusing to eat, sialorrhea; Pathogenic heat fumigate extremity, then brothers' herpes.The application of above three kinds of Chinese medicines is intended to eliminating carbuncle eliminating stagnation, detoxification sore treatment, fundamentally eliminates the inherent inducement causing herpes.Because multi-flavor property of medicine bitterness in side is trembled with fear, injuring spleen-stomach, therefore add Herba Pogostemonis, Rhizoma Cimicifugae assistant cold-damp processed in perfect square, row removing dampness to restore normal function of the stomach, the merit of elevate a turnable ladder yang-energy, and Rhizoma Cimicifugae has the effect delivering rash concurrently simultaneously, reduces the side effect of said medicine.The application of Rhizoma Imperatae, Cortex Moutan and Semen phaseoli radiati, has heat clearing away dissipating blood stasis concurrently while coordinating the actions of various ingredients in a prescription, the effect of quenching the thirst of subsiding a swelling.Patent of the present invention is directly for the typical pathologic feature medication of children's's hand-foot-mouth disease disease, and internal and external application, fundamentally solves the symptom of infantile hyperpyrexia, tic and hand-foot-mouth disease herpes, reduces the generation of complication.
The beneficial effect adopting technique scheme to produce is: what in Chinese medicine oral liquid prescription of the present invention, consumption was maximum is Gypsum Fibrosum, can bring down a fever fast, next is Radix Isatidis, Rhizoma Cimicifugae, Herba Pogostemonis etc. have clearing away heat and eliminating dampness, the medicine of effect of removing toxic substances rash, have good curative effect to disappearing of erythra, above medicine is mainly for the cardinal symptom of hand-foot-mouth disease: heating, herpes.Other drug promotes the effect that the healing of oral ulcer, prevention neurological complication etc. are different as Herba Taraxaci, Rhizoma Coptidis, Cortex Moutan, Rhizoma Imperatae, Semen phaseoli radiati, Ramulus Uncariae Cum Uncis etc. then have, Chinese medicine oral liquid of the present invention has no side effect, significant curative effect is had for plain edition Hand-Food-Mouth Disease, and be conducive to the recovery of body temperature, herpes drying, incrustation etc., obviously can reduce the probability that infant transforms to serious symptom.
Detailed description of the invention
Embodiment 1
The Chinese medicine oral liquid for the treatment of Hand-Food-Mouth Disease, takes following raw material of Chinese medicine:
Gypsum Fibrosum 480g, Radix Isatidis 40g, Rhizoma Cimicifugae 40g, Herba Pogostemonis 40g, Herba Taraxaci 120g, Rhizoma Coptidis 40g, Rhizoma Imperatae 280g, Cortex Moutan 40g, Semen phaseoli radiati 280g, Ramulus Uncariae Cum Uncis 320g.
Preparation method, comprises the following steps:
(1) above-mentioned raw material of Chinese medicine is extracted 2 times, first time adds 10 times of water gagings, decocts 1.5 hours, and second time adds 6 times of water gagings, decocts 1 hour, merges twice decoction liquor;
(2) relative density of putting in vacuum concentrator when being concentrated into 45 DEG C is 1.05 ~ 1.15, and during vacuum concentration, temperature is below 60 DEG C, and vacuum is 0.08Mpa;
(3) concentrated solution step (2) obtained is centrifugal, revolution 16000-20000r/min, filters, adds the sodium benzoate antiseptic of appropriate simple syrup (sugar content is 30%) and 0.2% in filtrate;
(4) sterilizing: adopt Arnold steam sterilizor sterilization, parameter is 100 DEG C, 30min.
Embodiment 2
The Chinese medicine oral liquid for the treatment of Hand-Food-Mouth Disease, takes following raw material of Chinese medicine:
Gypsum Fibrosum 680g, Radix Isatidis 200g, Rhizoma Cimicifugae 200g, Herba Pogostemonis 200g, Herba Taraxaci 320g, Rhizoma Coptidis 200g, Rhizoma Imperatae 480g, Cortex Moutan 200g, Semen phaseoli radiati 520g, Ramulus Uncariae Cum Uncis 640g.
Preparation method comprises the following steps:
(1) above-mentioned raw material of Chinese medicine is extracted 2 times, first time adds 10 times of water gagings, decocts 2 hours, and second time adds 7 times of water gagings, decocts 2 hours, merges twice decoction liquor;
(2) relative density of putting in vacuum concentrator when being concentrated into 45 DEG C is 1.05 ~ 1.15, and during vacuum concentration, temperature is below 60 DEG C, and vacuum is 0.08Mpa;
(3) concentrated solution step (2) obtained is centrifugal, revolution 16000-20000r/min, filters, adds the sodium benzoate antiseptic of appropriate simple syrup (sugar content is 30%) and 0.2% in filtrate;
(4) sterilizing: adopt Arnold steam sterilizor sterilization, parameter is 100 DEG C, 30min.
Embodiment 3
The Chinese medicine oral liquid for the treatment of Hand-Food-Mouth Disease, takes following raw material of Chinese medicine:
Gypsum Fibrosum 500g, Radix Isatidis 100g, Rhizoma Cimicifugae 100g, Herba Pogostemonis 100g, Herba Taraxaci 240g, Rhizoma Coptidis 150g, Rhizoma Imperatae 300g, Cortex Moutan 100g, Semen phaseoli radiati 400g, Ramulus Uncariae Cum Uncis 640g.
Preparation method comprises the following steps:
(1) above-mentioned raw material of Chinese medicine is extracted 2 times, first time adds 8 times of water gagings, decocts 1.5 hours, and second time adds 6 times of water gagings, decocts 1.5 hours, merges twice decoction liquor;
(2) relative density of putting in vacuum concentrator when being concentrated into 45 DEG C is 1.05 ~ 1.15, and during vacuum concentration, temperature is below 60 DEG C, and vacuum is 0.08Mpa;
(3) concentrated solution step (2) obtained is centrifugal, revolution 16000-20000r/min, filters, adds the sodium benzoate antiseptic of appropriate simple syrup (sugar content is 30%) and 0.2% in filtrate;
(4) sterilizing: adopt Arnold steam sterilizor sterilization, parameter is 100 DEG C, 30min.
Embodiment 4
The Chinese medicine oral liquid for the treatment of Hand-Food-Mouth Disease, takes following raw material of Chinese medicine: Gypsum Fibrosum 160g, Radix Isatidis 40g, Rhizoma Cimicifugae 40g, Herba Pogostemonis 40g, Herba Taraxaci 70g, Rhizoma Coptidis 10g, Rhizoma Imperatae 90g, Cortex Moutan 30g, Semen phaseoli radiati 110g, Ramulus Uncariae Cum Uncis 120g.
Preparation method, comprises the following steps:
(1) above-mentioned raw material of Chinese medicine is extracted 2 times, first time adds 10 times of water gagings, decocts 1.5 hours, and second time adds 6 times of water gagings, decocts 1 hour, merges twice decoction liquor;
(2) relative density of putting in vacuum concentrator when being concentrated into 45 DEG C is 1.05 ~ 1.15, and during vacuum concentration, temperature is below 60 DEG C, and vacuum is 0.08Mpa;
(3) concentrated solution step (2) obtained is centrifugal, revolution 16000-20000r/min, filters, adds the sodium benzoate antiseptic of appropriate simple syrup (sugar content is 30%) and 0.2% in filtrate;
(4) sterilizing: adopt Arnold steam sterilizor sterilization, parameter is 100 DEG C, 30min.
Embodiment 5
The Chinese medicine oral liquid for the treatment of Hand-Food-Mouth Disease, takes following raw material of Chinese medicine: Gypsum Fibrosum 120g, Radix Isatidis 50g, Rhizoma Cimicifugae 10g, Herba Pogostemonis 20g, Herba Taraxaci 80g, Rhizoma Coptidis 30g, Rhizoma Imperatae 120g, Cortex Moutan 50g, Semen phaseoli radiati 130g, Ramulus Uncariae Cum Uncis 80g.
Preparation method, comprises the following steps:
(1) above-mentioned raw material of Chinese medicine is extracted 2 times, first time adds 8 times of water gagings, decocts 1 hour, and second time adds 7 times of water gagings, decocts 1 hour, merges twice decoction liquor;
(2) relative density of putting in vacuum concentrator when being concentrated into 45 DEG C is 1.05 ~ 1.15, and during vacuum concentration, temperature is below 60 DEG C, and vacuum is 0.08Mpa;
(3) concentrated solution step (2) obtained is centrifugal, revolution 16000-20000r/min, filters, adds the sodium benzoate antiseptic of appropriate simple syrup (sugar content is 30%) and 0.2% in filtrate;
(4) sterilizing: adopt Arnold steam sterilizor sterilization, parameter is 100 DEG C, 30min.
Embodiment 6
The Chinese medicine oral liquid for the treatment of Hand-Food-Mouth Disease, takes following raw material of Chinese medicine: Gypsum Fibrosum 180g, Radix Isatidis 10g, Rhizoma Cimicifugae 50g, Herba Pogostemonis 50g, Herba Taraxaci 30g, Rhizoma Coptidis 50g, Rhizoma Imperatae 70g, Cortex Moutan 10g, Semen phaseoli radiati 70g, Ramulus Uncariae Cum Uncis 140g.
Preparation method, comprises the following steps:
(1) above-mentioned raw material of Chinese medicine is extracted 2 times, first time adds 12 times of water gagings, decocts 2 hours, and second time adds 7 times of water gagings, decocts 2 hours, merges twice decoction liquor;
(2) relative density of putting in vacuum concentrator when being concentrated into 45 DEG C is 1.05 ~ 1.15, and during vacuum concentration, temperature is below 60 DEG C, and vacuum is 0.08Mpa;
(3) concentrated solution step (2) obtained is centrifugal, revolution 16000-20000r/min, filters, adds the sodium benzoate antiseptic of appropriate simple syrup (sugar content is 30%) and 0.2% in filtrate;
(4) sterilizing: adopt Arnold steam sterilizor sterilization, parameter is 100 DEG C, 30min.
Embodiment 7
The Chinese medicine oral liquid for the treatment of Hand-Food-Mouth Disease, takes following raw material of Chinese medicine: Gypsum Fibrosum 140g, Radix Isatidis 20g, Rhizoma Cimicifugae 20g, Herba Pogostemonis 10g, Herba Taraxaci 50g, Rhizoma Coptidis 10g, Rhizoma Imperatae 110g, Cortex Moutan 20g, Semen phaseoli radiati 90g, Ramulus Uncariae Cum Uncis 100g.
Preparation method, comprises the following steps:
(1) above-mentioned raw material of Chinese medicine is extracted 2 times, first time adds 11 times of water gagings, decocts 1.5 hours, and second time adds 7 times of water gagings, decocts 1 hour, merges twice decoction liquor;
(2) relative density of putting in vacuum concentrator when being concentrated into 45 DEG C is 1.05 ~ 1.15, and during vacuum concentration, temperature is below 60 DEG C, and vacuum is 0.08Mpa;
(3) concentrated solution step (2) obtained is centrifugal, revolution 16000-20000r/min, filters, adds the sodium benzoate antiseptic of appropriate simple syrup (sugar content is 30%) and 0.2% in filtrate;
(4) sterilizing: adopt Arnold steam sterilizor sterilization, parameter is 100 DEG C, 30min.
Embodiment 8
The Chinese medicine oral liquid for the treatment of Hand-Food-Mouth Disease, takes following raw material of Chinese medicine: Gypsum Fibrosum 170g, Radix Isatidis 40g, Rhizoma Cimicifugae 40g, Herba Pogostemonis 40g, Herba Taraxaci 70g, Rhizoma Coptidis 10g, Rhizoma Imperatae 80g, Cortex Moutan 40g, Semen phaseoli radiati 110g, Ramulus Uncariae Cum Uncis 130g.
Preparation method, comprises the following steps:
(1) above-mentioned raw material of Chinese medicine is extracted 2 times, first time adds 10 times of water gagings, decocts 1.5 hours, and second time adds 6 times of water gagings, decocts 1 hour, merges twice decoction liquor;
(2) relative density of putting in vacuum concentrator when being concentrated into 45 DEG C is 1.05 ~ 1.15, and during vacuum concentration, temperature is below 60 DEG C, and vacuum is 0.08Mpa;
(3) concentrated solution step (2) obtained is centrifugal, revolution 16000-20000r/min, filters, adds the sodium benzoate antiseptic of appropriate simple syrup (sugar content is 30%) and 0.2% in filtrate;
(4) sterilizing: adopt Arnold steam sterilizor sterilization, parameter is 100 DEG C, 30min.
Embodiment 9
The Chinese medicine oral liquid for the treatment of Hand-Food-Mouth Disease, takes following raw material of Chinese medicine: Gypsum Fibrosum 150g, Radix Isatidis 30g, Rhizoma Cimicifugae 25g, Herba Pogostemonis 35g, Herba Taraxaci 40g, Rhizoma Coptidis 10g, Rhizoma Imperatae 80g, Cortex Moutan 40g, Semen phaseoli radiati 110g, Ramulus Uncariae Cum Uncis 150g.
Preparation method, comprises the following steps:
(1) above-mentioned raw material of Chinese medicine is extracted 2 times, first time adds 10 times of water gagings, decocts 1.5 hours, and second time adds 6 times of water gagings, decocts 1 hour, merges twice decoction liquor;
(2) relative density of putting in vacuum concentrator when being concentrated into 45 DEG C is 1.05 ~ 1.15, and during vacuum concentration, temperature is below 60 DEG C, and vacuum is 0.08Mpa;
(3) concentrated solution step (2) obtained is centrifugal, revolution 16000-20000r/min, filters, adds the sodium benzoate antiseptic of appropriate simple syrup (sugar content is 30%) and 0.2% in filtrate;
(4) sterilizing: adopt Arnold steam sterilizor sterilization, parameter is 100 DEG C, 30min.
Embodiment 10 ~ 15
Raw material composition is in table 1
Table 1 raw material forms
Preparation method is with embodiment 1.
The traditional Chinese medical science think the etiology and pathogenesis of Hand-Food-Mouth Disease be diseases caused by exogenous pathogenic factor seasonal pathogen virus, in have damp-heat in the spleen and stomach or intrinsic heat, inside and outside heresy is fought knot mutually, follows arteries and veins and goes, upper steaming dispute, disorder of the spleen and stomach caused by internal damage, outer and four ends, therefore see aphtha of the mouth and tongue, ulcer and brothers' heart herpes, minority patient with severe symptoms there will be pathogenic poison invading toward interior, hoodwink pericardium, liver-wind being stirred up, alter and meridians, sick position, at lung, spleen, relates to the heart, liver, brain key.Control with heat-clearing and toxic substances removing pathogenic fire purging, removing heat from blood eliminating dampness method.Bringing down a fever, promoting in the comprehensive effect such as herpes and (or) deflorescence, mitigation symptoms, the shortening course of disease, treatment cross-reference compares significance.
Below clinical test results of the present invention:
Patient's physical data:
Adopt random controls principle to select plain edition hand-foot-mouth disease case 226 example, be divided into three groups at random: adopt Chinese medicine oral liquid treatment group of the present invention (being called for short treatment by Chinese herbs group), symptomatic treatment group, Chinese and Western in conjunction with group.Infant ordinary circumstance is in table 2, and two groups of basic condition no significant differences, have comparability.
Table 2 infant physical data
Compare between three groups:
p> 0.05
Therapeutic Method: treatment by Chinese herbs group gives oral liquid treatment of the present invention, one time 1, often prop up 10ml, oral, 3 times on the one, symptomatic treatment group gives the treatment of conventional fluid infusion vitimin supplement, and apply Antipyretics thing if desired and bring down a fever, Chinese and Western adds on symptomatic treatment basis in conjunction with group uses Chinese medicine oral liquid of the present invention, 1, often prop up 10ml, oral, 3 times on the one.
Clinical efficacy situation analysis:
Curative effect determinate standard: all cases all meet " hand-foot-mouth disease practice guidelines (version in 2010) " middle clinical criteria that health ministry is promulgated.Observation index: situation of change and glucose recovery normal time etc. before and after the treatment such as symptom, sign, the laboratory parameters such as the herpes at the position such as heating, hand-foot-mouth disease of infant and (or) erythra, cough, poor appetite.Cure: temperature recovery is normal, herpes be dry, incrustation, without sepage.Take a turn for the better: body temperature <37.5 DEG C, the drying of herpes major part, incrustation, visible a little herpes exists.Invalid: body temperature does not obviously change, herpes comparatively before slightly reduce, or there is the serious symptom shower such as nervous system, respiratory circulatory system damage.
Clinical test results: three groups of infant fever times, deflorescence times, general symptom improve situations and to lapse to etc. respectively in table 3,4,5 and 6.Three groups of laboratory examination results compare: liver function, hemoglobin, platelet unknown significance difference before and after the medication of each group.
Table 3 three groups of fever times compare (
± s)
Compare between three groups,
p>0.05
Table 4 three groups of deflorescence time compares (
± s)
Compare between three groups,
p<0.05
Three groups, table 5 general symptom improvement situation compares (
± s)
Cough symptom number of cases is in table 2: because of number of cases very little, do not compare between three groups.Poor appetite symptom: compare between three groups,
p>0.05.
Three groups, table 6 lapses to and compares
Research conclusion: three groups of patients compare, the improvement situation comparing difference of temperature recovery time, general symptom without significance (
p>0.05); Herpes and (or) deflorescence time compare have significant difference (
p<0.05), simple Chinese drug-treated group curative effect is best; Three groups lapse to situation and compare: Chinese and Western is in conjunction with group and treatment by Chinese herbs group infant without transferring heavy case person to, and symptomatic treatment group has 8 routine infants to transfer heavy type to.Point out alone Chinese medicine oral liquid of the present invention treatment plain edition hand-foot-mouth disease safe and effective, have and significantly bring down a fever, promote the comprehensive effect such as herpes and (or) deflorescence, mitigation symptoms, the shortening course of disease.Result of study points out Clinical practice Be very effective of the present invention.
Claims (5)
1. treat a Chinese medicine oral liquid for Hand-Food-Mouth Disease, it is characterized in that: crude drug is made up of the Chinese crude drug of following weight parts: Gypsum Fibrosum 12 ~ 18, Radix Isatidis 1 ~ 5, Rhizoma Cimicifugae 1 ~ 5, Herba Pogostemonis 1 ~ 5, Herba Taraxaci 3 ~ 8, Rhizoma Coptidis 1 ~ 5, Rhizoma Imperatae 7 ~ 12, Cortex Moutan 1 ~ 5, Semen phaseoli radiati 7 ~ 13, Ramulus Uncariae Cum Uncis 8 ~ 14;
Preparation method, comprises the following steps:
(1) take raw material of Chinese medicine according to weight proportion, first time adds 8 ~ 12 times of water gagings, decocts 1 ~ 2 hour, and second time adds 6 ~ 7 times of water gagings, decocts 1 ~ 2 hour, merges twice decoction liquor;
(2) relative density of putting in vacuum concentrator when being concentrated into 45 DEG C is 1.05 ~ 1.15;
(3) concentrated solution step (2) obtained is centrifugal, revolution 16000-20000r/min, filters;
(4) sterilizing.
2. a kind of Chinese medicine oral liquid for the treatment of Hand-Food-Mouth Disease as claimed in claim 1, is characterized in that: crude drug is made up of the Chinese crude drug of following weight parts: Gypsum Fibrosum 14 ~ 17, Radix Isatidis 2 ~ 5, Rhizoma Cimicifugae 2 ~ 5, Herba Pogostemonis 2 ~ 5, Herba Taraxaci 5 ~ 8, Rhizoma Coptidis 1 ~ 3, Rhizoma Imperatae 8 ~ 11, Cortex Moutan 2 ~ 4, Semen phaseoli radiati 9 ~ 13, Ramulus Uncariae Cum Uncis 10 ~ 13.
3. a kind of Chinese medicine oral liquid for the treatment of Hand-Food-Mouth Disease as claimed in claim 1, is characterized in that: crude drug is made up of the Chinese crude drug of following weight parts: Gypsum Fibrosum 16, Radix Isatidis 4, Rhizoma Cimicifugae 4, Herba Pogostemonis 4, Herba Taraxaci 7, Rhizoma Coptidis 1, Rhizoma Imperatae 9, Cortex Moutan 3, Semen phaseoli radiati 11, Ramulus Uncariae Cum Uncis 12.
4. a kind of Chinese medicine oral liquid for the treatment of Hand-Food-Mouth Disease as claimed in claim 1, is characterized in that: in step (1), first time adds 10 times of water gagings, decocts 1.5 hours, adds 6 times of water gagings for the second time, decocts 1 hour.
5. a kind of Chinese medicine oral liquid for the treatment of Hand-Food-Mouth Disease as claimed in claim 1, is characterized in that: in step (2), during vacuum concentration, temperature is below 60 DEG C, and vacuum is 0.08Mpa.
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| CN105412767A (en) * | 2015-12-17 | 2016-03-23 | 济南昊泽环保科技有限公司 | Sterilization oral liquid for treating ordinary hand-foot-mouth disease |
| CN105770432A (en) * | 2016-02-15 | 2016-07-20 | 徐芬 | Method for preventing child hand-foot-and-mouth disease |
| CN107929573B (en) * | 2017-11-09 | 2020-08-11 | 广州市中医医院（广州市中医中药研究所） | Traditional Chinese medicine for treating hand-foot-and-mouth disease and preparation method thereof |
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