CN104116960A - Traditional Chinese medicinal preparation for treating hand-foot-and-mouth disease - Google Patents
Traditional Chinese medicinal preparation for treating hand-foot-and-mouth disease Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicinal preparation for treating the hand-foot-and-mouth disease. The preparation is prepared from the following raw medicinal materials by weight: 20-30g of radix isatidis, 10-20g of fructus forsythiae, 10-20g of folium isatidis, 10-20g of herba eupatorii, 10-20g of bamboo leaf, 10-20g of mint, 10-20g of cape jasmine, 10-20g of junci medulla, 8-12g of dried tangerine peel, 8-15g of hawthorn, 8-12g of radix adenophorae, 8-12g of schisandra chinensis, 8-12g of oriental wormwood, 8-12g of rheum officinale and 8-12g of periostracum cicada. The medicinal materials are compatible to play roles in clearing heat to remove toxicity, clearing heart and purging spleen, dispelling wind and removing toxicity, cooling blood and promoting diuresis, can be easily accepted by patients, and have the advantages of comprehensive drug absorption, short course of treatment, quick response and the like when being used for treating the hand-foot-and-mouth disease. The traditional Chinese medicinal preparation is worthy of clinical popularization and application.
Description
Technical field
The invention belongs to the field of Chinese medicines, specifically a kind of Chinese medicine preparation that can treat hand-foot-mouth disease.
Background technology
Hand-foot-mouth disease is the common transmittable disease being caused by multiple enterovirus, is mainly to be caused by Coxsackie virus, all may fall ill throughout the year, but ill maximum with summer and autumn, any age all can fall ill, especially 3 years old following child.Virus parasite, in pharyngeal, saliva, herpes and the feces of infant, not only can pass through saliva, sneeze, cough, and other child is given in the droplet infection while speaking, also can pass through the indirect infections such as hands, the articles for daily use and tableware.Once popular, will make a lot of children infected, can there is similar varicelliform exanthema vesiculosum in the child on infected, thereby be called as hand, mouth and foot diseases on hands, skin of foot or oral mucosa.
Most of hand-foot-mouth disease patients are common case, show as: Acute onset, and heating, there is herpes in oral mucosa, and there is maculopapule, herpes in hands, foot and buttocks, and herpes has blush around, and in bleb, liquid is less.With symptoms such as cough, watery nasal discharge, inappetence.Some cases only shows as erythra or Herpangina.General about 1 week of the state of an illness, severe patient can Complicating Pneumonia In Patients, myocarditis, aseptic meningitis, pulmonary edema.
Due to hand-foot-mouth disease, patient has oral ulcer more, causes the problems such as stomatalgia, sialorrhea, refusing to eat, anorexia, little oral solid formulation difficulty of infant age in addition again, and also there is side effect in various degree in medicine mostly, affects the normal g and D of infant.Need the one pathogenesis that can effectively hit therefore clinical badly, accelerate infant heating, deflorescence, promote clinical recovery, at utmost reduce the Chinese medicine preparation of infant misery.
Summary of the invention
The present invention has overcome at present in the technical deficiency existing aspect treatment hand-foot-mouth disease, and a kind of taking convenience, determined curative effect, the Chinese medicine preparation that safe and reliable, cure rate is high are provided.
The technical solution adopted in the present invention is: a kind of Chinese medicine preparation for the treatment of hand-foot-mouth disease, it is characterized in that, and described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
Radix Isatidis 20-30 gram, Fructus Forsythiae 10-20 gram, Folium Isatidis 10-20 gram, Herba Eupatorii 10-20 gram, Folium Bambusae 10-20 gram, Herba Menthae 10-20 gram, Fructus Gardeniae 10-20 gram, Medulla Junci 10-20 gram, Pericarpium Citri Reticulatae 8-12 gram, Fructus Crataegi 8-15 gram, Radix Adenophorae (Radix Glehniae) 8-12 gram, Fructus Schisandrae Chinensis 8-12 gram, Herba Artemisiae Scopariae 8-12 gram, Radix Et Rhizoma Rhei 8-12 gram, Periostracum Cicadae 8-12 gram.
As this kind of prioritization scheme:
Described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
20 grams of Radix Isatidis, 10 grams of Fructus Forsythiaes, 10 grams of Folium Isatidiss, 10 grams of Herba Eupatoriis, 10 grams, Folium Bambusae, 10 grams of Herba Menthaes, 10 grams of Fructus Gardeniaes, 10 grams of Medulla Juncies, 8 grams of Pericarpium Citri Reticulataes, 8 grams of Fructus Crataegis, 8 grams of Radix Adenophorae (Radix Glehniae), 8 grams of Fructus Schisandrae Chinensis, 8 grams of Herba Artemisiae Scopariaes, 8 grams of Radix Et Rhizoma Rhei, 8 grams of Periostracum Cicadaes.
As this kind of prioritization scheme:
Described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
25 grams of Radix Isatidis, 15 grams of Fructus Forsythiaes, 15 grams of Folium Isatidiss, 15 grams of Herba Eupatoriis, 15 grams, Folium Bambusae, 15 grams of Herba Menthaes, 15 grams of Fructus Gardeniaes, 15 grams of Medulla Juncies, 10 grams of Pericarpium Citri Reticulataes, 12 grams of Fructus Crataegis, 10 grams of Radix Adenophorae (Radix Glehniae), 10 grams of Fructus Schisandrae Chinensis, 10 grams of Herba Artemisiae Scopariaes, 10 grams of Radix Et Rhizoma Rhei, 10 grams of Periostracum Cicadaes.
As this kind of prioritization scheme:
Described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
30 grams of Radix Isatidis, 20 grams of Fructus Forsythiaes, 20 grams of Folium Isatidiss, 20 grams of Herba Eupatoriis, 20 grams, Folium Bambusae, 20 grams of Herba Menthaes, 20 grams of Fructus Gardeniaes, 20 grams of Medulla Juncies, 12 grams of Pericarpium Citri Reticulataes, 15 grams of Fructus Crataegis, 12 grams of Radix Adenophorae (Radix Glehniae), 12 grams of Fructus Schisandrae Chinensis, 12 grams of Herba Artemisiae Scopariaes, 12 grams of Radix Et Rhizoma Rhei, 12 grams of Periostracum Cicadaes.
The instructions of taking of above-mentioned Chinese medicine preparation is: after the raw material Chinese medicine of above-mentioned weight proportion is mixed, get its medicine juice, 1 dose of every day, every day 3-4 time according to the method for the fried Chinese medicine of tradition.Consumption is 0-2 year, 10ml/ time; 2-4 year, 30ml/ time; 4-8 year, 50ml/ time; More than 8 years old, 80ml/ time.With disease plus-minus drug dose.
The raw material Chinese medicine of above-mentioned Chinese medicine preparation:
Radix Isatidis, bitter in the mouth, cold in nature; GUIXIN, stomach, liver, gallbladder meridian.There is heat-clearing and toxic substances removing, effect of removing heat from blood sore-throat relieving.
Fructus Forsythiae, bitter in the mouth, cold nature; Return lung, heart channel.There is effect of heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, benefiting QI for strengthening the superficies.
Folium Isatidis, bitter in the mouth, cold in nature; GUIXIN, lung, stomach warp.There is heat-clearing and toxic substances removing, effect of blood cooling and ecchymoses removing.
Herba Eupatorii, acrid in the mouth, property is flat; Return spleen, stomach, lung meridian.There is removing dampness by means of aromatics, effect of eliminating summer-heat from the exterior.
Folium Bambusae, sweet in the mouth, cold in nature; GUIXIN, lung, gallbladder, stomach warp.There is clearing heat and relieving fidgetness, effect of the diuresis of promoting the production of body fluid.
Herba Menthae, acrid in the mouth, cool in nature; Return lung, Liver Channel.Merit has dispelling wind and heat pathogens, the clear sharp head, sore-throat relieving rash, effect of dispersing the stagnated live-QI to relieve the stagnation of QI.
Fructus Gardeniae, bitter in the mouth, cold in nature; Return lung, kidney, the heart, liver, tri-jiao channel.There is pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, effect of reducing swelling and alleviating pain.
Medulla Junci, sweet in the mouth, cold nature; GUIXIN, lung, small intestine meridian.There is relieving stranguria by diuresis, effect of the relieving restlessness that clears away heart-fire.
Pericarpium Citri Reticulatae, acrid in the mouth, hardship, warm in nature; Return spleen, stomach, lung meridian.There is regulating the flow of Qi and the middle Jiao, drying dampness to eliminate phlegm, effect of diuretic relieving constipation.
Fructus Crataegi, sour in the mouth, sweet, slightly warm in nature; Return spleen, stomach, Liver Channel.There is promoting digestion and removing stagnation, effect of promoting blood circulation to remove blood stasis.
Radix Adenophorae (Radix Glehniae), sweet in the mouth, cold nature; Return spleen, lung meridian.There is clearing lung and nourishing yin, effect of reinforcing stomach reg fluid.
Fructus Schisandrae Chinensis, sour in the mouth, warm in nature; Return lung, kidney, heart channel.There is the nourishing kidney of astringing the lung, the arresting sweating that promotes the production of body fluid, effect of arresting seminal emission antidiarrheal.
Herba Artemisiae Scopariae, bitter in the mouth, cold nature; Return spleen, stomach, liver, gallbladder meridian.There is clearing away heat-damp and promoting diuresis, effect of promoting the function of the gallbladder to alleviate jaundice.
Radix Et Rhizoma Rhei, bitter in the mouth, cold in nature; Return spleen, stomach, large intestine, liver, pericardium channel.There is heat and toxic materials clearing away, clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body, effect of blood circulation promoting and blood stasis dispelling.
Periostracum Cicadae, sweet in the mouth, salty, cool in nature; Return lung, Liver Channel.There is dispelling wind-heat, rash sore-throat relieving, effect of removing nebula to improve visual acuity.
The traditional Chinese medical science thinks, hand-foot-mouth disease is many because experiencing epidemic disease poison seasonal pathogen, the damp and hot poison that accumulates, and lung is defended first and is subject to, and sick position is dirty at lung, spleen, the heart three.Because the agile susceptible heresy of child's internal organs is impaired, in noxious dampness, accumulate, intimately flourishing, interior diplomacy are striven, thus control with heat-clearing and toxic substances removing, removing heat from blood dampness removing, the purgation of spleen excess that clears away heart-fire, removing toxic substances rash is method.In Chinese medicine preparation of the present invention, Radix Isatidis, Fructus Forsythiae, Folium Isatidis can heat-clearing and toxic substances removing, benefiting QI for strengthening the superficies, removing heat from blood sore-throat relieving; Herba Eupatorii, Pericarpium Citri Reticulatae, Fructus Crataegi can regulating the flow of Qi and the middle Jiaos, drying dampness to eliminate phlegm, diuretic relieving constipation; The relieving restlessness that can clear away heart-fire of Folium Bambusae, Medulla Junci, Herba Artemisiae Scopariae, the diuresis of promoting the production of body fluid; Herba Menthae, Periostracum Cicadae can dispelling wind-heat, rash sore-throat relieving; Fructus Gardeniae, Radix Et Rhizoma Rhei can clearing away heat-fires, removing pathogenic heat from blood and toxic substance from the body, reducing swelling and alleviating pain; The nourishing kidney of can astringing the lung of Radix Adenophorae (Radix Glehniae), Fructus Schisandrae Chinensis, reinforcing stomach reg fluid, strengthening the body resistance.All medicine compatibilities are superior, can be effectively for infant diseases caused by exogenous pathogenic factor seasonal pathogen epidemic disease poison, and to defend table and held back, the pathogenesis of Lung Qi obstraction, adjusts body internal organs, reaches treating both the principal and secondary aspects of a disease.
For further investigating clinical efficacy and the safety of medicine of the present invention, we have selected 146 routine hand-foot-mouth disease patients to test, male 91 examples, and female 55.Wherein treatment group 76 examples, male 48 examples, female's 28 examples; Age 1-13 year, 2.5 years old mean age, course of disease 2-6 days, average 3 days.Matched group 70 examples, male 43 examples, female's 27 examples; Age 0.5-8 year, 2 years old mean age; Course of disease 1-5 days, average 2 days.Two groups of patients' age, sex, body weight, sick time, disease symptom isobase data Epidemiological Analysis by statistics, difference not statistically significant (P > 0.05), has comparability.
Clinical symptoms performance: Acute onset, heating, body temperature is many at 37.5-39 DEG C, how without the situation such as aversion to cold, perspiration.There is being dispersed in herpes in oral mucosa, swallows red, sialorrhea, and look indolent and listless, and light red tongue is red or deep red, greasy fur on tongue, and rapid pulse or count accurately, fingerprint is purplish red or dark violet.There is maculopapule, herpes in hands, foot and buttocks, herpes can have inflammatory blush around, and in bleb, liquid is less, is similar to white painful abdominal mass.Can be with symptoms such as cough, watery nasal discharge, inappetence.Some cases only shows as erythra or herpangina.How in one week, to fully recover, prognosis bona.As without erythra, the clinical hand-foot-mouth disease that generally should not be diagnosed as.
Therapeutic Method:
Treatment group is taken Chinese medicine preparation of the present invention, 1 dose of every day, decocting.Consumption is 0-2 year, 10ml/ time; 2-4 year, 30ml/ time; 4-8 year, 50ml/ time; More than 8 years old, 80ml/ time.All take 3-4 time every day above, with disease plus-minus drug dose.It is oral that matched group is taken antiviral drugs (ribavirin granule agent: children's every day is by body weight 10-15mg/kg, points 3 times oral, is used in conjunction 7 days), vitamin B, vitamin C etc.
Symptomatic treatment: if infant body temperature exceedes 39 DEG C, continue the above person of 2h, can use nonsteroidal anti inflammatory antipyretic, can vein liquid make-up when high temperature continues.
Criterion of therapeutical effect:
Cure: transference cure, temperature recovery is normal, and herpes disappears.
Take a turn for the better: symptom alleviates, and temperature recovery is normal, and herpes disappears substantially.
Invalid: symptom is unchanged.
Efficacy result:
1. Clinical efficacy comparison:
After treatment, treatment group is cured 40 examples, 34 examples that take a turn for the better, and invalid 2 examples, effective percentage is 97.4%.Matched group is cured 19 examples, 30 examples that take a turn for the better, and invalid 21 examples, effective percentage is 70.0%.Compared significant difference for two groups, the curative effect for the treatment of group is significantly better than matched group (P < 0.05).Detailed results is in table 1.
Table 1: the curative effect comparision result table after two groups of case treatments
| Group | Number of cases | Cure n (%) | Improvement n (%) | Invalid n (%) | Effective percentage n (%) |
| Treatment group | 76 | 40(52.6) | 34(44.7) | 2(2.6) | 74(97.4) |
| Matched group | 70 | 19(27.2) | 30(42.9) | 21(30.0) | 49(70.0) |
2. liang group transference cure time comparison:
Treatment discovery, treatment group fever time and erythra, herpes of mouth regression time have significant difference compared with matched group, and the resolution of symptoms time for the treatment of group is significantly better than matched group (P < 0.05).Detailed results is in table 2.
Table 2: two groups of case transference cure time results of comparison tables
| Group | Number of cases | Fever time | Erythra and herpes of mouth |
| Treatment group | 76 | 2.0±1.0 | 2.0±1.0 |
| Matched group | 70 | 2.5±1.0 | 3.5±1.0 |
3. bad should be compared:
Adding up the side effect reaction of two groups of patients in therapeutic process, there is not obvious adverse reaction in treatment group, and matched group has loss of appetite, feel sick, and vomiting, laxativeness, dyspnea, the untoward reaction such as erythra occur.
Result shows, Chinese medicine preparation treatment hand-foot-mouth disease determined curative effect of the present invention, safe and reliable, cheap, have no side effect, move back in heat, be all better than western medicine, clinic promotion and application aspect deflorescence time and clinical general curative effect.
Detailed description of the invention
Embodiment 1: a kind of Chinese medicine preparation for the treatment of hand-foot-mouth disease, choose 20 grams of Radix Isatidis, 10 grams of Fructus Forsythiaes, 10 grams of Folium Isatidiss, 10 grams of Herba Eupatoriis, 10 grams, Folium Bambusae, 10 grams of Herba Menthaes, 10 grams of Fructus Gardeniaes, 10 grams of Medulla Juncies, 8 grams of Pericarpium Citri Reticulataes, 8 grams of Fructus Crataegis, 8 grams of Radix Adenophorae (Radix Glehniae), 8 grams of Fructus Schisandrae Chinensis, 8 grams of Herba Artemisiae Scopariaes, 8 grams of Radix Et Rhizoma Rhei, 8 grams of Periostracum Cicadaes.
Embodiment 2: a kind of Chinese medicine preparation for the treatment of hand-foot-mouth disease, choose 25 grams of Radix Isatidis, 15 grams of Fructus Forsythiaes, 15 grams of Folium Isatidiss, 15 grams of Herba Eupatoriis, 15 grams, Folium Bambusae, 15 grams of Herba Menthaes, 15 grams of Fructus Gardeniaes, 15 grams of Medulla Juncies, 10 grams of Pericarpium Citri Reticulataes, 12 grams of Fructus Crataegis, 10 grams of Radix Adenophorae (Radix Glehniae), 10 grams of Fructus Schisandrae Chinensis, 10 grams of Herba Artemisiae Scopariaes, 10 grams of Radix Et Rhizoma Rhei, 10 grams of Periostracum Cicadaes.
Embodiment 3: a kind of Chinese medicine preparation for the treatment of hand-foot-mouth disease, choose 30 grams of Radix Isatidis, 20 grams of Fructus Forsythiaes, 20 grams of Folium Isatidiss, 20 grams of Herba Eupatoriis, 20 grams, Folium Bambusae, 20 grams of Herba Menthaes, 20 grams of Fructus Gardeniaes, 20 grams of Medulla Juncies, 12 grams of Pericarpium Citri Reticulataes, 15 grams of Fructus Crataegis, 12 grams of Radix Adenophorae (Radix Glehniae), 12 grams of Fructus Schisandrae Chinensis, 12 grams of Herba Artemisiae Scopariaes, 12 grams of Radix Et Rhizoma Rhei, 12 grams of Periostracum Cicadaes.
Below by concrete case, Chinese medicine preparation curative effect of the present invention is further verified:
Case 1
Chen, man, 6 years old.On infant during kindergarten, a lot of red herpess of hand-foot-mouth disease projection, red tongue, yellow and greasy fur, rapid pulse, without heating paresthesia.Be hand-foot-mouth disease after diagnosing, beaten after 3 days garters in hospital, herpes fails to eliminate.After being introduced, take medicine of the present invention, after decocting, each serving with 50ml, take every day 3 times.After 1 day, herpes obviously alleviates, and takes herpes after 2 days and all eliminates, infant recovery from illness.
Case 2
Ma, female, 3 years old.On infant, during kindergarten, there is erythema in trick place, oral area, also has the symptom of fever, and household just sends them to examination in hospital.Be diagnosed as hand-foot-mouth disease.Parents with Children upon somebody's introduction, adopts medicine of the present invention to treat infant, after decocting, each serving with 30ml, takes after three times, and fever symptoms disappears; Take after 2 days, brothers' oral area erythema all obviously alleviates; Infant was taken medicine after three days, and symptom all disappears, through hospital clinical diagnosis, and infant recovery from illness.
Case 3
Shut out certain, female, 5 years old.On infant, during kindergarten, often will good classmate exchange toy play with one, rear classmate is diagnosed as (after hand-foot-mouth disease) three days, and infant is also infected, occurs fever, cough, and rhinorrhea symptom, there is erythema in foot place, oral area.Take medicine of the present invention and treat, each 50ml, day takes 4 times, after one day, burn move back, cough and watery nasal discharge alleviate; Take after 2 days, cough, watery nasal discharge disappear, and erythema alleviates; Take after three days, erythema disappears, and examination in hospital is diagnosed as disease recovery from illness.
Claims (4)
1. a Chinese medicine preparation for the treatment of hand-foot-mouth disease, is characterized in that, described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
Radix Isatidis 20-30 gram, Fructus Forsythiae 10-20 gram, Folium Isatidis 10-20 gram, Herba Eupatorii 10-20 gram, Folium Bambusae 10-20 gram, Herba Menthae 10-20 gram, Fructus Gardeniae 10-20 gram, Medulla Junci 10-20 gram, Pericarpium Citri Reticulatae 8-12 gram, Fructus Crataegi 8-15 gram, Radix Adenophorae (Radix Glehniae) 8-12 gram, Fructus Schisandrae Chinensis 8-12 gram, Herba Artemisiae Scopariae 8-12 gram, Radix Et Rhizoma Rhei 8-12 gram, Periostracum Cicadae 8-12 gram.
2. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
20 grams of Radix Isatidis, 10 grams of Fructus Forsythiaes, 10 grams of Folium Isatidiss, 10 grams of Herba Eupatoriis, 10 grams, Folium Bambusae, 10 grams of Herba Menthaes, 10 grams of Fructus Gardeniaes, 10 grams of Medulla Juncies, 8 grams of Pericarpium Citri Reticulataes, 8 grams of Fructus Crataegis, 8 grams of Radix Adenophorae (Radix Glehniae), 8 grams of Fructus Schisandrae Chinensis, 8 grams of Herba Artemisiae Scopariaes, 8 grams of Radix Et Rhizoma Rhei, 8 grams of Periostracum Cicadaes.
3. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
25 grams of Radix Isatidis, 15 grams of Fructus Forsythiaes, 15 grams of Folium Isatidiss, 15 grams of Herba Eupatoriis, 15 grams, Folium Bambusae, 15 grams of Herba Menthaes, 15 grams of Fructus Gardeniaes, 15 grams of Medulla Juncies, 10 grams of Pericarpium Citri Reticulataes, 12 grams of Fructus Crataegis, 10 grams of Radix Adenophorae (Radix Glehniae), 10 grams of Fructus Schisandrae Chinensis, 10 grams of Herba Artemisiae Scopariaes, 10 grams of Radix Et Rhizoma Rhei, 10 grams of Periostracum Cicadaes.
4. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
30 grams of Radix Isatidis, 20 grams of Fructus Forsythiaes, 20 grams of Folium Isatidiss, 20 grams of Herba Eupatoriis, 20 grams, Folium Bambusae, 20 grams of Herba Menthaes, 20 grams of Fructus Gardeniaes, 20 grams of Medulla Juncies, 12 grams of Pericarpium Citri Reticulataes, 15 grams of Fructus Crataegis, 12 grams of Radix Adenophorae (Radix Glehniae), 12 grams of Fructus Schisandrae Chinensis, 12 grams of Herba Artemisiae Scopariaes, 12 grams of Radix Et Rhizoma Rhei, 12 grams of Periostracum Cicadaes.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105106891A (en) * | 2015-09-14 | 2015-12-02 | 陈巧真 | Traditional Chinese medicine composition for preventing and treating hand-foot-mouth disease |
| CN105412767A (en) * | 2015-12-17 | 2016-03-23 | 济南昊泽环保科技有限公司 | Sterilization oral liquid for treating ordinary hand-foot-mouth disease |
-
2014
- 2014-08-03 CN CN201410391736.6A patent/CN104116960A/en active Pending
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| 张国梁等: ""手足口病中医药防治实践回顾性分析(二)"", 《中医药临床杂志》 * |
| 徐爱年等: ""中药内外合治轻症手足口病36例疗效观察"", 《中国中西医结合儿科学》 * |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105106891A (en) * | 2015-09-14 | 2015-12-02 | 陈巧真 | Traditional Chinese medicine composition for preventing and treating hand-foot-mouth disease |
| CN105412767A (en) * | 2015-12-17 | 2016-03-23 | 济南昊泽环保科技有限公司 | Sterilization oral liquid for treating ordinary hand-foot-mouth disease |
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