CN101804100A - Effervescent Chinese medicinal composition with effect of clearing away lung-heat and releasing toxin and preparation method thereof - Google Patents
Effervescent Chinese medicinal composition with effect of clearing away lung-heat and releasing toxin and preparation method thereof Download PDFInfo
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- CN101804100A CN101804100A CN200910228409A CN200910228409A CN101804100A CN 101804100 A CN101804100 A CN 101804100A CN 200910228409 A CN200910228409 A CN 200910228409A CN 200910228409 A CN200910228409 A CN 200910228409A CN 101804100 A CN101804100 A CN 101804100A
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- effervescent
- chinese medicinal
- medicinal composition
- rhizoma fagopyri
- fagopyri dibotryis
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Abstract
The invention relates to an effervescent Chinese medicinal composition with effect of clearing away lung-heat and releasing toxin and a preparation method thereof. The effervescent Chinese medicinal composition comprises the following components in percentage by weight: 50 to 80 percent of wild buckwheat rhizome, 10 to 50 percent of effervescing agent and 10 to 20 percent of lubricant. The effervescent Chinese medicinal composition has the advantages of scientific and reasonable formula, no toxic or side effect or medicament residue, convenient use, quick response and high bioavailability, can effectively kill poison and inhibit bacteria, and meets the requirement on the safety of veterinary medicaments and animal-derived foods.
Description
Technical field
The invention belongs to poultry and use field of veterinary, especially a kind of effervescent Chinese medicinal composition and preparation method thereof with lung-heat clearing and detoxification function.
Background technology
China is livestock and poultry cultivation big country, and the R﹠D work of treatment livestock and poultry medicine did not all stop all the time.In the face of the market trend who becomes better and better, countries in the world require also more and more higher to edible safety, along with progress of science and technology, increasing drug residue is detected and confirms health harmful, countries in the world are all in the supervision that strengthens the residual problem of medicine, this has also produced no small impact to China's livestock and poultry breeding industry, and has proposed a urgent problem.The theory of scientific culture also is rooted in the hearts of the people simultaneously, simplifies and cultures operation, saves aquaculture cost and has become the current problem of being concerned about most of raiser.In the poultry farming process, lung-heat clearing and detoxification is untimely, and regular meeting causes poultry respiratory infection, symptoms such as cough with asthma, rapid breathing, bronchial mucosa are hemorrhage, pulmonary edema occur, and serious also can cause death, and brings great economic loss to the raiser.This product has the lung-heat clearing and detoxification function, can prevent the generation of poultry disease of bronchus in advance, also has very strong therapeutical effect simultaneously, and medicine is rapid-action, is convenient to absorb.
Summary of the invention
The object of the present invention is to provide a kind of effervescent Chinese medicinal composition with lung-heat clearing and detoxification function, this Chinese medicine composition has no side effect and drug residue, simplifies the operation, and saves aquaculture cost, easy to use, onset is rapid, can effectively kill virus antibacterial and bioavailability high.
Another object of the present invention is to provide a kind of preparation method with effervescent Chinese medicinal composition of lung-heat clearing and detoxification function.
The present invention is achieved by the following technical solutions:
A kind of effervescent Chinese medicinal composition with lung-heat clearing and detoxification function, the component of its effervescent Chinese medicinal composition and percentage by weight thereof are:
Rhizoma Fagopyri Dibotryis 40-80%;
Effervescent 10-50%;
Lubricant 4-20%.
And described effervescent is combined by weight 1: 1 by the wherein a kind of and sodium bicarbonate in tartaric acid, citric acid, the adipic acid.
And described lubricant is wherein a kind of in sucralose, erythritol, magnesium stearate, the dodecyl sodium sulfate.
A kind of preparation method with effervescent Chinese medicinal composition of lung-heat clearing and detoxification function, the step of its preparation method is:
(1) Rhizoma Fagopyri Dibotryis that takes by weighing 1/2 weight according to weight proportion is pulverized, decoct twice, collecting decoction, filter, filtrate is condensed into the Rhizoma Fagopyri Dibotryis thick paste, and the Rhizoma Fagopyri Dibotryis that takes by weighing other 1/2 weight again is ground into the back all by 80～100 mesh sieves, with Rhizoma Fagopyri Dibotryis thick paste mix homogeneously, all by 80～100 mesh sieves, the back Rhizoma Fagopyri Dibotryis obtains sieving after the drying and crushing;
(2) take by weighing effervescent, lubricant according to weight proportion and pulverize respectively, every kind of raw material with the abundant mix homogeneously of Rhizoma Fagopyri Dibotryis afterwards that sieves in the effervescent after sieving, lubricant and the step (1), obtains mixture respectively all by 80～100 mesh sieves;
(3) be binding agent system soft material with the mixture in the step (2) with concentration 50～60% alcoholic solution of 2～4%PVP, cross all by 10～15 mesh sieve system granules, 50～60 ℃ of following aeration-dryings, again all by 20～30 mesh sieves, obtain granulate, carry out tabletting then, promptly obtain having the effervescent Chinese medicinal composition finished product of lung-heat clearing and detoxification function.
Advantage of the present invention and beneficial effect are:
1, in this effervescent Chinese medicinal composition with Rhizoma Fagopyri Dibotryis as the natural Chinese medicine composition, have good heat-clearing and toxic substances removing, lung heat clearing evacuation of pus, function of promoting blood circulation to disperse blood clots.As the natural Chinese medicines extract, do not have any poisonous and harmful substance simultaneously, can not produce toxic and side effects, more can not exert an influence health to animal body.And the effervescent technology is introduced cleverly in the tablet of this medicine into, save a large amount of manpower and materials, the effective ingredient in the medicine is dissolved rapidly and uniformly, be convenient to poultry absorb, improve bioavailability, can significantly improve the clinical efficacy of medicine.
2, this effervescent Chinese medicinal composition adopts Rhizoma Fagopyri Dibotryis effectively to improve cultivated animals immunity, and hepatic cholagogic reduces disease and takes place, and the effervescent The Application of Technology has been saved aquaculture cost, only needs to throw in fowl drinking water to get final product, and has simplified operation.
3, the present invention fills a prescription and forms scientific and reasonablely, has no side effect and drug residue, and is easy to use, onset is rapid, can effectively kill virus antibacterial and bioavailability high, meet safe veterinary drug, ensure the animal-derived food safe requirement.
The specific embodiment
The present invention is described in further detail by following examples.Need to prove: following embodiment is illustrative, is not determinate, can not limit protection scope of the present invention with following embodiment.
Rhizoma Fagopyri Dibotryis in the component of the present invention, tartaric acid, citric acid, adipic acid, sodium bicarbonate, sucralose, erythritol, magnesium stearate, dodecyl sodium sulfate all can be bought on market and obtain.
Embodiment 1
A kind of effervescent Chinese medicinal composition with lung-heat clearing and detoxification function, the component of its effervescent Chinese medicinal composition and weight are respectively Rhizoma Fagopyri Dibotryis 80Kg, effervescent 16Kg, lubricant 4Kg; Above-mentioned effervescent is made up of citric acid 8Kg and sodium bicarbonate 8Kg, and lubricant is a magnesium stearate.
A kind of preparation method with effervescent Chinese medicinal composition of lung-heat clearing and detoxification function, the step of its preparation method is:
(1) Rhizoma Fagopyri Dibotryis that takes by weighing 1/2 weight according to weight proportion is pulverized, decoct twice, collecting decoction, filter, filtrate is condensed into the Rhizoma Fagopyri Dibotryis thick paste, and the Rhizoma Fagopyri Dibotryis that takes by weighing other 1/2 weight again is ground into the back all by 80 mesh sieves, with Rhizoma Fagopyri Dibotryis thick paste mix homogeneously, all by 80 mesh sieves, the back Rhizoma Fagopyri Dibotryis obtains sieving after the drying and crushing;
(2) according to weight proportion take by weighing effervescent, lubricant is pulverized respectively, every kind of raw material with the abundant mix homogeneously of Rhizoma Fagopyri Dibotryis afterwards that sieves in the effervescent after sieving, lubricant and the step (1), obtains mixture respectively all by 80 mesh sieves;
(3) be binding agent system soft material with the mixture in the step (2) with 50% alcoholic solution of 2%PVP, cross all by 10 mesh sieve system granules, 50 ℃ of following aeration-dryings, again all by 20 mesh sieves, obtain granulate, carry out tabletting then, promptly obtain having the effervescent Chinese medicinal composition finished product of lung-heat clearing and detoxification function.
Embodiment 2
A kind of effervescent Chinese medicinal composition with lung-heat clearing and detoxification function, the component of its effervescent Chinese medicinal composition and weight are respectively Rhizoma Fagopyri Dibotryis 70Kg, effervescent 20Kg, lubricant 10Kg; Above-mentioned effervescent is made up of tartaric acid 10Kg and sodium bicarbonate 10Kg, and lubricant is an erythritol.
A kind of preparation method with effervescent Chinese medicinal composition of lung-heat clearing and detoxification function, the step of its preparation method is:
(1) Rhizoma Fagopyri Dibotryis that takes by weighing 1/2 weight according to weight proportion is pulverized, decoct twice, collecting decoction, filter, filtrate is condensed into the Rhizoma Fagopyri Dibotryis thick paste, and the Rhizoma Fagopyri Dibotryis that takes by weighing other 1/2 weight again is ground into the back all by 100 mesh sieves, with Rhizoma Fagopyri Dibotryis thick paste mix homogeneously, all by 100 mesh sieves, the back Rhizoma Fagopyri Dibotryis obtains sieving after the drying and crushing;
(2) according to weight proportion take by weighing effervescent, lubricant is pulverized respectively, every kind of raw material with the abundant mix homogeneously of Rhizoma Fagopyri Dibotryis afterwards that sieves in the effervescent after sieving, lubricant and the step (1), obtains mixture respectively all by 100 mesh sieves;
(3) be binding agent system soft material with the mixture in the step (2) with 60% alcoholic solution of 4%PVP, cross all by 15 mesh sieve system granules, 60 ℃ of following aeration-dryings, again all by 30 mesh sieves, obtain granulate, carry out tabletting then, promptly obtain having the effervescent Chinese medicinal composition finished product of lung-heat clearing and detoxification function.
Embodiment 3
A kind of effervescent Chinese medicinal composition with lung-heat clearing and detoxification function, the component of its effervescent Chinese medicinal composition and weight are respectively Rhizoma Fagopyri Dibotryis 40Kg, effervescent 50Kg, lubricant 10Kg; Above-mentioned effervescent is made up of adipic acid 25Kg and sodium bicarbonate 25Kg, and lubricant is a sucralose.
A kind of preparation method with effervescent Chinese medicinal composition of lung-heat clearing and detoxification function, the step of its preparation method is:
(1) Rhizoma Fagopyri Dibotryis that takes by weighing 1/2 weight according to weight proportion is pulverized, decoct twice, collecting decoction, filter, filtrate is condensed into the Rhizoma Fagopyri Dibotryis thick paste, and the Rhizoma Fagopyri Dibotryis that takes by weighing other 1/2 weight again is ground into the back all by 90 mesh sieves, with Rhizoma Fagopyri Dibotryis thick paste mix homogeneously, all by 90 mesh sieves, the back Rhizoma Fagopyri Dibotryis obtains sieving after the drying and crushing;
(2) according to weight proportion take by weighing effervescent, lubricant is pulverized respectively, every kind of raw material with the abundant mix homogeneously of Rhizoma Fagopyri Dibotryis afterwards that sieves in the effervescent after sieving, lubricant and the step (1), obtains mixture respectively all by 90 mesh sieves;
(3) be binding agent system soft material with the mixture in the step (2) with 55% alcoholic solution of 3%PVP, cross all by 12 mesh sieve system granules, 55 ℃ of following aeration-dryings, again all by 25 mesh sieves, obtain granulate, carry out tabletting then, promptly obtain having the effervescent Chinese medicinal composition finished product of lung-heat clearing and detoxification function.
Embodiment 4
A kind of effervescent Chinese medicinal composition with lung-heat clearing and detoxification function, the component of its effervescent Chinese medicinal composition and weight are respectively Rhizoma Fagopyri Dibotryis 60Kg, effervescent 20Kg, lubricant 20Kg; Above-mentioned effervescent is made up of citric acid 10Kg and sodium bicarbonate 10Kg, and lubricant is a dodecyl sodium sulfate.
The step of its preparation method is with embodiment 1.
Embodiment 5
A kind of effervescent Chinese medicinal composition with lung-heat clearing and detoxification function, the component and the weight of its effervescent Chinese medicinal composition are respectively: Rhizoma Fagopyri Dibotryis 80Kg, effervescent 10Kg, lubricant 10Kg; Above-mentioned effervescent is made up of citric acid 5Kg and sodium bicarbonate 5Kg, and lubricant is a magnesium stearate.
The step of its preparation method is with embodiment 1.
Originally the effervescent Chinese medicinal composition that has the lung-heat clearing and detoxification function does not need dissolving in advance in application, directly drop into and culture in the fowl drinking water, and the per kilogram water body gets final product with this effervescent Chinese medicinal composition 1 gram-10 grams.
The clinical practice experiment
1, experimental technique
200 of Luo Man egg breed chickens selecting 240 ages in days not fall ill are divided into two groups at random, and one group is adopted common Rhizoma Fagopyri Dibotryis sheet to prevent, and one group is prevented with the present invention; 200 of Luo Man egg breed chickens selecting 240 ages in days the respiratory tract infection symptom to occur are divided into two groups at random, and one group is adopted common Rhizoma Fagopyri Dibotryis sheet to treat, treats with the present invention for one group.
2, experimental result
The morbidity rehabilitation situation of testing with chicken through the primary part observation record obtains the result, and the experiment of prevention group all is effectively controlled with the chicken incidence, and the state of an illness does not have further spreading trend; Treatment group therapeutic effect is obvious, and administration adopted experimental group cure rate of the present invention to reach 96% after 3 days, improves 13% than the experimental group that adopts common Rhizoma Fagopyri Dibotryis sheet.With SPSS12.0 statistics software analysis, administration is after 3 days, treatment group and matched group cure rate significant difference (p＜0.05).
The characteristic of component among the present invention
1, Rhizoma Fagopyri Dibotryis:
(1) antitumaous effect: Rhizoma Fagopyri Dibotryis root water decoction 20g (crude drug)/(kgd) and 13.3g (crude drug)/(kgd) irritate stomach, and 10d all has significant inhibitory effect to Mice Bearing Lewis Lung Cancer and cervical cancer U14 continuously, the curative effect of female mice than male mice for well.Utilize grafting (SRCA) under the mice scrotum film, stereomutation was with the antitumaous effect of prediction and evaluation Rhizoma Fagopyri Dibotryis extract gold E and CD1 before and after relatively cancerous lung tissue was transplanted.The 1st～5d behind the SRCA, continuous 5 oral golden E of mice or CD1, dosage is each 100mg/kg, and result of the test shows that the effective ratio of golden E and CD1 is 4/10 and 2/10, and lung squamous cancer is higher than the pulmonary carcinoma of other types of organizations to the sensitivity of golden E treatment.Rhizoma Fagopyri Dibotryis root element (Fagopyrum CymosumRootin, FCR) be the comprehensive tannin mixture of a class that from the Rhizoma Fagopyri Dibotryis root, proposes, when every 1ml concentration is 125 μ g, suppression ratio to adenocarcinoma of lung (GLC), squamous carcinoma of the cervix (HeLa), the growth of nasopharyngeal squamous cell carcinoma (KB) cell is respectively 84.5%, 78.9%, 100%, makes film, RNA, DNA metabolism, the karyokinesis damaged of cancerous cell.Find that also FCR has the remarkable effect that GLC, Hela, KB and adenocarcinoma of stomach cell SGC human cancer cell clone form that suppresses, suppression ratio is directly proportional with concentration, and suppression ratio is respectively when low concentration 12.5 μ g/ml: GLC89.7%, HeLa53.8%, SGC65.4%, K connect the killer cell method, colony cultivates the inhibition method and the DNA precursor substance mixes the antitumaous effect of method research Rhizoma Fagopyri Dibotryis root to the various human cancerous cell of In vitro culture.As a result, this medicine when lg/L to the kill rate of various human cancerous cell all above a log kill, the kill rate that concentration is reduced to 0.125g/L still reaches 74.3%～92.1% near a log kill.Extract in the Rhizoma Fagopyri Dibotryis root has tangible antitumaous effect, and to be 0.1g/L, 0.05g/L reach 100% to the colony suppression ratio of multiple cancerous cell to its concentration.Suppression ratio reached 75.1%～89.2% when concentration was 0.0125g/L.Reuse 3H-TdR labelling method observe to find, the effective chemical extract of Rhizoma Fagopyri Dibotryis root is the nucleic acid metabolism in the anticancer obviously, its inhibitory action and positive control fluorouracil approximate [5,6] with concentration.
(2) the bacteriostasis Rhizoma Fagopyri Dibotryis all has inhibitory action to staphylococcus aureus, streptococcus pneumoniae, escherichia coli, bacillus pyocyaneus, and liquor-saturated dose of effect is greater than water preparation.Other has report; Rhizoma Fagopyri Dibotryis and each separating part thereof do not have vitro antibacterial activity; different times lumbar injection Rhizoma Fagopyri Dibotryis extractum 83mg/kg before infecting has significant protective effect to abdominal cavity infection staphylococcus aureus mice, but is infecting simultaneously or infecting then unprotect effect of back medication.
(3) other effect Rhizoma Fagopyri Dibotryis extractum 83mg/kg lumbar injection can strengthen the phagocytic function of Turnover of Mouse Peritoneal Macrophages, but the macrophage sum is not seen and increased.The oral Rhizoma Fagopyri Dibotryis extractum of triple vaccine pyrogenicity rabbit has refrigeration function, slight antitussive effect is arranged for the oral Rhizoma Fagopyri Dibotryis extractum of mice.
(4) toxicity Rhizoma Fagopyri Dibotryis extract gold E group mice 100mg/kg, behind the 5d oral administration, the weight of animals and spleen weight obviously alleviate than matched group continuously, and dosage is as being increased to 500mg/kg, and spleen heavily alleviates then more obvious.
2, effervescent tablet is a kind of novel tablet of external in recent years Application and Development, the difference of it and conventional tablet, just be that it also contains gas-producing disintegrant, after effervescent tablet is put into water, under the effect of gas-producing disintegrant, produce a large amount of bubbles (carbon dioxide) at once, make rapid disintegrate of tablet and thawing, sometimes the bubble that disintegrate produces also can make tablet roll up and down in water, quickens its disintegrate and thawing.
Claims (4)
1. effervescent Chinese medicinal composition with lung-heat clearing and detoxification function, it is characterized in that: the component of this effervescent Chinese medicinal composition and percentage by weight thereof are:
Rhizoma Fagopyri Dibotryis 40-80%;
Effervescent 10-50%;
Lubricant 4-20%.
2. the effervescent Chinese medicinal composition with lung-heat clearing and detoxification function according to claim 1 is characterized in that: described effervescent is combined by weight 1: 1 by the wherein a kind of and sodium bicarbonate in tartaric acid, citric acid, the adipic acid.
3. the effervescent Chinese medicinal composition with lung-heat clearing and detoxification function according to claim 1 is characterized in that: described lubricant is wherein a kind of in sucralose, erythritol, magnesium stearate, the dodecyl sodium sulfate.
4. preparation method with effervescent Chinese medicinal composition of lung-heat clearing and detoxification function as claimed in claim 1, it is characterized in that: the step of this preparation method is:
(1) Rhizoma Fagopyri Dibotryis that takes by weighing 1/2 weight according to weight proportion is pulverized, decoct twice, collecting decoction, filter, filtrate is condensed into the Rhizoma Fagopyri Dibotryis thick paste, and the Rhizoma Fagopyri Dibotryis that takes by weighing other 1/2 weight again is ground into the back all by 80～100 mesh sieves, with Rhizoma Fagopyri Dibotryis thick paste mix homogeneously, all by 80～100 mesh sieves, the back Rhizoma Fagopyri Dibotryis obtains sieving after the drying and crushing;
(2) take by weighing effervescent, lubricant according to weight proportion and pulverize respectively, every kind of raw material with the abundant mix homogeneously of Rhizoma Fagopyri Dibotryis afterwards that sieves in the effervescent after sieving, lubricant and the step (1), obtains mixture respectively all by 80～100 mesh sieves;
(3) be binding agent system soft material with the mixture in the step (2) with concentration 50～60% alcoholic solution of 2～4%PVP, cross all by 10～15 mesh sieve system granules, 50～60 ℃ of following aeration-dryings, again all by 20～30 mesh sieves, obtain granulate, carry out tabletting then, promptly obtain having the effervescent Chinese medicinal composition finished product of lung-heat clearing and detoxification function.
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| Application Number | Priority Date | Filing Date | Title |
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| CN200910228409A CN101804100A (en) | 2009-11-16 | 2009-11-16 | Effervescent Chinese medicinal composition with effect of clearing away lung-heat and releasing toxin and preparation method thereof |
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| CN200910228409A CN101804100A (en) | 2009-11-16 | 2009-11-16 | Effervescent Chinese medicinal composition with effect of clearing away lung-heat and releasing toxin and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102687781A (en) * | 2012-05-23 | 2012-09-26 | 耿福能 | Tartary buckwheat tea effervescent tablets and preparation method thereof |
| CN105687342A (en) * | 2016-03-17 | 2016-06-22 | 四川农业大学 | Powder capable of clearing lung, resisting inflammation and relieving cough and preparation method thereof |
-
2009
- 2009-11-16 CN CN200910228409A patent/CN101804100A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102687781A (en) * | 2012-05-23 | 2012-09-26 | 耿福能 | Tartary buckwheat tea effervescent tablets and preparation method thereof |
| CN105687342A (en) * | 2016-03-17 | 2016-06-22 | 四川农业大学 | Powder capable of clearing lung, resisting inflammation and relieving cough and preparation method thereof |
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Open date: 20100818 |