CN102641354B - Veterinary compound pure traditional Chinese medicine preparation for treating coccidium and preparing method and application thereof - Google Patents
Veterinary compound pure traditional Chinese medicine preparation for treating coccidium and preparing method and application thereof Download PDFInfo
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Abstract
The invention provides a veterinary compound pure traditional Chinese medicine preparation for treating coccidium and a preparing method and application thereof. The compound traditional Chinese medicine preparation is composed of granatum, polygonum aviculare, potentilla discolor, codonopsis polosula, astragalus mongholicus, radix paeoniae alba, hawthorn and liquorice. The compound traditional Chinese medicine preparation is used for treating coccidium and is not prone to generate drug resistance. The invention further provides the preparation method and application of the compound traditional Chinese medicine preparation. The compound traditional Chinese medicine preparation can easily obtain raw materials and can be prepared into different drug forms of granula, powder, premix, oral liquid and the like.
Description
Technical field
The present invention relates to a kind of compound recipe pure Chinese medicinal preparation for the treatment of coccidiosis and preparation method thereof and application, belong to veterinary drug research and development technology field.
Background technology
Coccidiosis is one of disease of global popular serious harm livestock and poultry breeding industry, and primary disease distributes wide, the infection rate height.Be accompanied by the continuous development of aquaculture, the morbidity of coccidiosis has not had seasonality, and chicken group's coccidium infection rate is more than 80%, and the infection of duck goose also increases day by day.Cause after the infection chicken large quantities of morbidities and dead, hinder growth promoter, the price of deed reduces, and endangers very seriously, makes aquaculture cost improve greatly.According to investigations, whole world every year because of coccidiosis cause with a toll of 1,500,000,000 dollars.
At present, prevention and treatment coccidiosis, chemicals is still in occupation of leading position.But in the process of constantly medication, polypide has produced drug resistance, can only continue to increase dosage in order effectively to treat coccidiosis.In recent years, more and more higher to the prescription of Fowl meat along with the raising of people's living standard, country requires also more and more stricter for the food drug residue.Therefore, a kind of effective treatment coccidiosis, difficult generation drug resistance and the low medicine of drug residue are demanded exploitation urgently.
CN1589847A (CN03150699.2) discloses a kind of compound Chinese medicinal preparation of preventing and treating coccidiosis, it is made up of main active material and auxiliary activity component substances, through pulverize, mix or with the useable solvents extraction, concentrate, dry, pulverize and be prepared into preparation.The main active material is: Radix Dichroae, Herba Artemisiae Annuae, the Radix Pulsatillae; The auxiliary activity component substances is: Herba Verbenae, Herba Portulacae, Herba Artemisiae Scopariae, Herba Pteridis Multifidae, Herba Chenopodii Hybridi.The weight ratio of main active material is 50～70%, and the weight ratio of auxiliary activity component substances is 30～0%, and it mixes pre-mixing agent capable of using as feed with adjuvant; Molten water can be used as drinking agent.The present invention had had both prevented and treated coccidiosis, was difficult for again producing left drug in drug resistance and the body, compared with prior art can reduce by 50% cost.
CN102319309A (CN201110228538.4) provides a kind of Chinese medicine preparation for the treatment of chicken coccidiosis, formed by Radix Dichroae, Herba Artemisiae Annuae, Radix Bupleuri, the Radix Pulsatillae, Ramulus Uncariae Cum Uncis, Herba Agrimoniae, Radix Sanguisorbae assembly, its preparation method comprises gets the raw materials ready, extracts, concentrates, adds starch, drying, pulverizing.It is Powdered that patent medicine is dark yellow in appearance, granularity and bulk density are even, it is strong to make an addition to the feedstuff adhesiveness, feedstuff dyeing variable color is coordinated and can not made to color and luster, have that parasite killing protects the liver, the effect of cooling blood for hemostasis, dampness-eliminating and dysentery-stopping, heat-clearing and toxic substances removing, the mixed infection that is adapted to treat chicken coccidiosis and coccidiosis and antibacterial.
Characteristics such as the active component of Chinese herbal medicine is abundant, treating both the principal and secondary aspects of a disease, difficult generation drug resistance make it have excellent research and are worth and development space.But all there is toxicity in the main insecticidal constituent of existing compound Chinese medicinal preparation, as Radix Dichroae, Fructus Bruceae, the Radix Pulsatillae etc., in case excessive use will produce toxic and side effects, even causes death.Therefore, its preparation toxicity has limited its clinical use.
Summary of the invention
At the deficiencies in the prior art, the invention provides a kind of Chinese traditional compound medicine for the treatment of coccidiosis.
The present invention also provides preparation method and the application of this Chinese traditional compound medicine.
Technical scheme of the present invention is as follows:
A kind of Chinese traditional compound medicine for the treatment of coccidiosis is made by the raw material of following weight portion,
Pericarpium Granati 10-100 Fen ， Herba Polygoni Avicularis 10-100 part, Herba Potentillae Discoloris 10-100 part, Radix Codonopsis 1-50 part, Radix Astragali 1-50 part, Radix Paeoniae Alba 1-50 part, Fructus Crataegi 1-50 part, Radix Glycyrrhizae 1-50 part.
By existing pharmaceutically acceptable technology, this compound preparation can be made into dosage forms such as oral liquid, granule, pulvis, pre-mixing agent, to make things convenient for the poultry administration.
Preferred according to the present invention, the Chinese traditional compound medicine for the treatment of coccidiosis, the parts by weight of raw materials proportioning is as follows:
Pericarpium Granati 30-80 Fen ， Herba Polygoni Avicularis 30-80 part, Herba Potentillae Discoloris 30-80 part, Radix Codonopsis 10-30 part, Radix Astragali 10-30 part, Radix Paeoniae Alba 10-30 part, Fructus Crataegi 10-30 part, Radix Glycyrrhizae 10-30 part.
Further preferred according to the present invention, the Chinese traditional compound medicine for the treatment of coccidiosis, the parts by weight of raw materials proportioning is as follows:
Pericarpium Granati 60 45 parts of Fen, Herba Polygoni Avicularis, 30 parts of Herba Potentillae Discoloris, 20 parts of Radix Codonopsis, 20 parts of the Radixs Astragali, 20 parts of the Radix Paeoniae Albas, 15 parts of Fructus Crataegis, 15 parts in Radix Glycyrrhizae.
One of according to the present invention, the preparation method of the Chinese traditional compound medicine of described treatment coccidiosis, preferred following:
A. the preparation of pulvis
With Pericarpium Granati ， Herba Polygoni Avicularis, Herba Potentillae Discoloris, Radix Codonopsis, the Radix Astragali, the Radix Paeoniae Alba, Fructus Crataegi, Radix Glycyrrhizae carry out micronizing respectively, cross 600 mesh sieves, and by the proportioning mixing, packing namely gets pulvis.
B. the preparation of granule
Get Pericarpium Granati ， Herba Polygoni Avicularis, Herba Potentillae Discoloris by proportioning, Radix Codonopsis, the Radix Astragali, the Radix Paeoniae Alba, Fructus Crataegi, the Radix Glycyrrhizae 20～30h that is soaked in water, 70～80 ℃ of heating and refluxing extraction 5～6 hours, filter, filtrate decompression is concentrated into the extractum of 1.3-1.5g/ml concentration, adds granulation adjuvant glucose then, integrate and granulate, the reduced vacuum drying is after the sieve granulate, packing namely gets granule.
C. the preparation of oral liquid
Get Pericarpium Granati ， Herba Polygoni Avicularis by proportioning, Herba Potentillae Discoloris, Radix Codonopsis, the Radix Astragali, the Radix Paeoniae Alba, Fructus Crataegi and the Radix Glycyrrhizae 20～30h that is soaked in water, the water yield there was not medical material to be advisable; 70～80 ℃ of heating and refluxing extraction 5～6 hours are filtered, and after the filtrate cooling, packing namely gets oral liquid.
D. the preparation of pre-mixing agent
Pulvis with a. preparation with appropriate amount of starch mix homogeneously, packing, namely gets pre-mixing agent.
In the preparation process of different dosage form, or have acceptable accessories to add, addition all gets final product by state of the art, and this belongs to well-known to those skilled in the art.
The present invention treat coccidiosis Chinese traditional compound medicine application, be used for anti-treatment fowl poultry coccidiosis, using method is as follows:
Pulvis and pre-mixing agent adopt the mixed feeding administration, and every 1kg feedstuff adds this product 10-20g;
Granule and oral liquid adopt and mix the drink administration, and every 1kg feeds and adds this product 10-20g in the water.
The present invention is the Chinese medicine compound pure Chinese medicinal preparation, is that monarch drug ， Herba Polygoni Avicularis is ministerial drug with the Pericarpium Granati, parasite killing; Herba Potentillae Discoloris, Radix Codonopsis, the Radix Astragali, the Radix Paeoniae Alba, Fructus Crataegi are adjuvant drug, are used for stopping blooding, enrich blood, spleen invigorating; Radix Glycyrrhizae is for making medicine, coordinating the actions of various ingredients in a prescription.This prescription,, is difficult for producing drug resistance in conjunction with practice on the basis of effective parasite killing from coccidiosis Chinese veterinarian theory, and drug residue is low, and suppresses the generation of complication, the effect of performance treating both the principal and secondary aspects of a disease.
The property of medicine of the present invention is moderate, does not contain toxic component, and eight flavor drug matchings take into account the monarch principle.According to the fowl poultry state of an illness using dosage that can scale up.
The selected eight flavor drug matching prescriptions of the present invention are made pure Chinese medicinal preparation, can reduce the chemical sproof generation of chemical medicine, and potentiation is arranged.Eight flavor Chinese medicines are widely distributed, and material is easy to get, and production technology is simple, convenient drug administration, greatly reduces and produces and use cost.
The specific embodiment
The present invention will be further described below in conjunction with embodiment, but be not limited thereto.
Embodiment 1: pulvis
With Pericarpium Granati 120kg, Herba Polygoni Avicularis 90, Herba Potentillae Discoloris 60kg, Radix Codonopsis 40kg, Radix Astragali 40kg, Radix Paeoniae Alba 40kg, Fructus Crataegi 30kg, Radix Glycyrrhizae 30kg, jet mill is pulverized, and pulverize the back and cross 600 mesh sieves, mixing, packing, namely.
Chicken farm effect experiment
From Shandong six and group plant chicken house and buy 80 of the assorted chickens of 1 age in days meat back, raise in the hen house of strict sterilization, feed with the standard compliant feedstuff that does not contain coccidiostat of autogamy, freely drink water.When brooding to 16 ages in days, at random 80 chickling are divided into 5 groups, 15 every group for examination.
Test grouping and administration: totally 5 groups of tests, the blank group does not infect not administration; Infect the matched group not administration of falling ill; For 1 group of compound recipe pulvis that adopts embodiment 1 of examination, the mixed feeding administration, every 1kg feedstuff adds this product 20g; Use diclazuril (available from Changzhou intelligent animals company limited) solution for 2 groups for examination, mix the drink administration, every 1L water adds this oral liquid 1mg; Adopt Maduramicin pre-mixing agent (available from the abundant biopharmaceutical company of Zhejiang health) for 3 groups for examination, per 1 kilogram of feed is added 10mg, mixed feeding administration; Except blank group and infection matched group, all the other are respectively organized in 18 ages in days and begin administration, are used in conjunction 7.
Test is with coccidian oocyst and infection method: test is provided by Shandong agricultural university animal medicine parasitic disease laboratory with the tender ear 1 coccidiosis spore egg capsule of liking to be beautiful, and after toxicity test, presses 10 * 10
4Individual/only contamination.Except the blank group, during 20 ages in days, to the artificial oral vaccination contamination of chicken.
Process of the test: after the contamination of 20 ages in days, observed 7 record chicken spirit, appetite, feces situation continuously.During 28 ages in days, all cut open and kill, observe caecum lesion, the egg sac number (OPG) with Maxwell method calculating cecal content calculates the egg capsule value by field, angle therapy for clearing away heat.Estimate according to indexs such as survival rate, rate of body weight gain, pathological changes value, anticoccidial index (ACI), egg capsule values and respectively to organize curative effect of medication.
The results are shown in Table 1:
Table 1, anticoccidial experimental result
| Group | The chicken number | Survival rate % | Rate of body weight gain % | The pathological changes value | The egg capsule value | ACI |
| The blank group | 15 | 100.00 | 100.00 | 0.0 | 0 | 200.00 |
| Infect matched group | 15 | 65.48 | 73.25 | 39.62 | 12 | 87.11 |
| For 1 group of examination | 15 | 100.00 | 93.24 | 7.0 | 0 | 186.24 |
| For 2 groups of examinations | 15 | 95.87 | 92.78 | 7.0 | 1 | 180.65 |
| For 3 groups of examinations | 15 | 90.65 | 89.76 | 9.3 | 1 | 170.11 |
Evidence, this product anticoccidial index (ACI) is greater than 180, and is obvious to the chicken coccidiosis curative effect, and therapeutic effect is better than solution of diclazuril and Maduramicin pre-mixing agent.
Embodiment 2: granule
With Pericarpium Granati 60kg, Herba Polygoni Avicularis 45kg, Herba Potentillae Discoloris 30kg, Radix Codonopsis 20kg, Radix Astragali 20kg, Radix Paeoniae Alba 20kg, Fructus Crataegi 15kg, Radix Glycyrrhizae 15kg, be soaked in water behind the 24h, 80 ℃ of heating and refluxing extraction 6 hours are filtered, and filtrate decompression is concentrated into the extractum that concentration is 1.3-1.5g/ml, in extract extractum, add glucose, integrate and granulate, the reduced vacuum drying is after the sieve granulate, packing namely gets granule.
Embodiment 3: oral liquid
With Pericarpium Granati 100kg, Herba Polygoni Avicularis 65kg, Herba Potentillae Discoloris 45kg, Radix Codonopsis 35kg, Radix Astragali 35kg, Radix Paeoniae Alba 35kg, Fructus Crataegi 20kg, Radix Glycyrrhizae 20kg, behind the water logging bubble 24h with 7 times of eight flavor medical material gross weights, 80 ℃ of heating and refluxing extraction 6 hours are filtered, filtrate cooling back packing namely gets oral liquid.
Claims (6)
1. a Chinese traditional compound medicine for the treatment of coccidiosis is characterized in that, made by the raw material of following weight portion,
Pericarpium Granati 10-100 Fen ， Herba Polygoni Avicularis 10-100 part, Herba Potentillae Discoloris 10-100 part, Radix Codonopsis 1-50 part, Radix Astragali 1-50 part, Radix Paeoniae Alba 1-50 part, Fructus Crataegi 1-50 part, Radix Glycyrrhizae 1-50 part.
2. the Chinese traditional compound medicine for the treatment of as claimed in claim 1 coccidiosis is characterized in that the parts by weight of raw materials proportioning is as follows:
Pericarpium Granati 30-80 Fen ， Herba Polygoni Avicularis 30-80 part, Herba Potentillae Discoloris 30-80 part, Radix Codonopsis 10-30 part, Radix Astragali 10-30 part, Radix Paeoniae Alba 10-30 part, Fructus Crataegi 10-30 part, Radix Glycyrrhizae 10-30 part.
3. the Chinese traditional compound medicine for the treatment of as claimed in claim 1 coccidiosis is characterized in that the parts by weight of raw materials proportioning is as follows:
Pericarpium Granati 60 45 parts of Fen, Herba Polygoni Avicularis, 30 parts of Herba Potentillae Discoloris, 20 parts of Radix Codonopsis, 20 parts of the Radixs Astragali, 20 parts of the Radix Paeoniae Albas, 15 parts of Fructus Crataegis, 15 parts in Radix Glycyrrhizae.
4. as the Chinese traditional compound medicine of each described treatment coccidiosis of claim 1～3, it is characterized in that this compound preparation is made oral liquid, granule, pulvis or pre-mixing agent.
5. as the preparation method of claim 1～4 Chinese traditional compound medicine for the treatment of coccidiosis as described in each, step such as one of following:
A. the preparation of pulvis
With Pericarpium Granati ， Herba Polygoni Avicularis, Herba Potentillae Discoloris, Radix Codonopsis, the Radix Astragali, the Radix Paeoniae Alba, Fructus Crataegi, Radix Glycyrrhizae carry out micronizing respectively, cross 600 mesh sieves, and by the proportioning mixing, packing namely gets pulvis;
B. the preparation of granule
Get Pericarpium Granati ， Herba Polygoni Avicularis, Herba Potentillae Discoloris by proportioning, Radix Codonopsis, the Radix Astragali, the Radix Paeoniae Alba, Fructus Crataegi, the Radix Glycyrrhizae 20～30h that is soaked in water, 70～80 ℃ of heating and refluxing extraction 5～6 hours, filter, filtrate decompression is concentrated into the extractum of 1.3-1.5g/ml concentration, adds granulation adjuvant glucose then, integrate and granulate, the reduced vacuum drying is after the sieve granulate, packing namely gets granule;
C. the preparation of oral liquid
Get Pericarpium Granati ， Herba Polygoni Avicularis by proportioning, Herba Potentillae Discoloris, Radix Codonopsis, the Radix Astragali, the Radix Paeoniae Alba, Fructus Crataegi and the Radix Glycyrrhizae 20～30h that is soaked in water, the water yield there was not medical material; 70～80 ℃ of heating and refluxing extraction 5～6 hours are filtered, and after the filtrate cooling, packing namely gets oral liquid;
D. the preparation of pre-mixing agent
Pulvis with a. preparation with appropriate amount of starch mix homogeneously, packing, namely gets pre-mixing agent.
6. the application of the Chinese traditional compound medicine of each described treatment coccidiosis of claim 1～3 is used for control fowl poultry coccidiosis, and using method is as follows:
Pulvis and pre-mixing agent adopt the mixed feeding administration, and every 1kg feedstuff adds the Chinese traditional compound medicine 10-20g of described treatment coccidiosis;
Granule and oral liquid adopt and mix the drink administration, and every 1kg feeds and adds the Chinese traditional compound medicine 10-20g of described treatment coccidiosis in the water.
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| CN105031245B (en) * | 2015-08-27 | 2018-09-28 | 山东恩康药业有限公司 | A kind of Chinese medicine composition of anti-Eimeria Tenella |
| CN106581488A (en) * | 2016-12-20 | 2017-04-26 | 柳江县素情家禽专业合作社 | Traditional Chinese medicine composition used for antibiotic-free breeding of free-range chickens |
| CN109588555A (en) * | 2018-12-26 | 2019-04-09 | 北京爱绿生物科技有限公司 | A kind of water-soluble natural plants anticoccidial feed addictive and preparation method thereof |
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| RU2180232C1 (en) * | 2001-06-15 | 2002-03-10 | Горшков Анатолий Николаевич | Agent eliciting antitumor activity |
| CN101564451A (en) * | 2008-04-24 | 2009-10-28 | 张其权 | Traditional Chinese medicine for curing chicken white diarrhea |
| CN101697775A (en) * | 2009-07-24 | 2010-04-28 | 王直军 | Traditional Chinese medicine feed additive for treating animal dysentery and diarrhea |
| CN102233027A (en) * | 2010-04-30 | 2011-11-09 | 刘国昌 | Traditional Chinese medicine for treating enteritis |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2180232C1 (en) * | 2001-06-15 | 2002-03-10 | Горшков Анатолий Николаевич | Agent eliciting antitumor activity |
| CN101564451A (en) * | 2008-04-24 | 2009-10-28 | 张其权 | Traditional Chinese medicine for curing chicken white diarrhea |
| CN101697775A (en) * | 2009-07-24 | 2010-04-28 | 王直军 | Traditional Chinese medicine feed additive for treating animal dysentery and diarrhea |
| CN102233027A (en) * | 2010-04-30 | 2011-11-09 | 刘国昌 | Traditional Chinese medicine for treating enteritis |
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