CN104522320B - A kind of natural plants anticoccidial feed addictive and its application - Google Patents
A kind of natural plants anticoccidial feed addictive and its application Download PDFInfo
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- CN104522320B CN104522320B CN201410832060.XA CN201410832060A CN104522320B CN 104522320 B CN104522320 B CN 104522320B CN 201410832060 A CN201410832060 A CN 201410832060A CN 104522320 B CN104522320 B CN 104522320B
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production
Abstract
The present invention relates to a kind of feed addictive and its application.The feed addictive is made by the raw material of following parts by weight：50 100 parts of Astragalus Root P.E, 50 150 parts of Artemisinin, 50 150 parts of Radix Dichroae extract, 50 100 parts of Herba Agrimoniae extract, 50 100 parts of eucommia ulmoides extracts, 50 100 parts of dandelion extract, 50 100 parts of atractylodes chinensis, 50 100 parts of mulberry-leaf extract, 50 100 parts of aloe extract, 50 100 parts of dried orange peel extracts, 100 parts of haw thorn extract 50g, 50 100 parts of licorice.Feed addictive of the present invention with suppression kill worm, strengthen immunity, repair intestines and stomach triple function, be adapted to widely popularize in animal husbandry.
Description
Technical field
The present invention relates to a kind of natural plants anticoccidial feed addictive and its application, belong to animal husbandry additive technology neck
Domain.
Background technology
In poultry cultivation, global-worm illness is one of disease of serious harm aquaculture, and the sick incidence is high, is distributed model
Enclose wide, its case fatality rate is up to 40%~80%.The anticoccidial drug that the country is used at present can be divided into three classes, and a class is polyethers ion
Carrier antibiotic, Equations of The Second Kind is chemical synthetic drug, and the 3rd class is natural plants (predominantly Chinese herbal and crude drugs preparations).Due to natural plants
Relative chemical synthetic drug and antibiotic are more environmentally-friendly, are favored by more and more animal husbandry personages.CN102552477A is disclosed
A kind of Chinese medicine composition for treating chicken coccidiasis, the component of its Chinese medicine composition is：Sweet wormwood；Changshan；The Radix Astragali；Hairyvein agrimony etc..
CN102100788A discloses a kind of Chinese medicine preparation for preventing and treating chicken coccidiasis, is with sweet wormwood, Changshan, the Radix Astragali, hairyvein agrimony
It is raw material Deng Chinese medicine, but above-mentioned composition directly uses Chinese herbal medicine, and addition is excessive, cost is too high, and harmful components can not be gone
Remove, the consequence such as its drug effect can not be fully used；CN101601751A discloses a kind of Chinese medicine composition for controlling chicken coccidiasis,
By sweet wormwood, hairyvein agrimony, Changshan, Radix Glycyrrhizae, the water extraction such as the Radix Astragali is prepared.But this is combined as drinking-water and taken, cumbersome using process, nothing
Method accurately controls consumption, wastes product, it is difficult to control effect etc.；
The content of the invention
In order to solve above-mentioned defect, the present invention provides a kind of safe and efficient, noresidue, is not likely to produce drug resistance
Anticoccidial feed addictive.
To achieve these goals, the present invention is adopted the following technical scheme that：
A kind of feed addictive, is made by the raw material of following parts by weight：50-100 parts of Astragalus Root P.E, Artemisinin
50-150 parts, 50-150 parts of Radix Dichroae extract, 50-100 parts of Herba Agrimoniae extract, 50-100 parts of eucommia ulmoides extracts, dandelion carry
50-100 parts of thing, 50-100 parts of atractylodes chinensis, 50-100 parts of mulberry-leaf extract, 50-100 parts of aloe extract, dried orange peel is taken to carry
Take 50-100 parts of thing, 50-100 parts of haw thorn extract, 50-100 parts of licorice.
In feed addictive of the present invention, the extract of each raw material can be obtained using field of Chinese medicines general extraction methods
Take, such as water extraction, alcohol extracting, it is also an option that commercially available each raw extract.Raw material is extracted in the present invention and is mainly purchased from Chengdu
Perseverance Easthome of city reaches bio tech ltd, and each extract active constituent content is as follows.Astragalus Root P.E：Content >=60-65%
Astragalus polyose (UV), content >=0.1-0.2% Astragaloside IVs (HPLC)；Artemisinin：Spice level (10:1)；Changshan is extracted
Thing：Drink water level, the orixine (UV) of content >=3%, the halofuginone hydrobromide (HPLC) of content >=0.5%；Herba Agrimoniae extract：Drinking-water level (15:
1)；Eucommia ulmoides extracts：Drink water level, the chlorogenic acid (HPLC) of content >=3%；Dandelion extract：Spice level (10:1), content >=
0.1% caffeic acid (HPLC)；Atractylodes chinensis：Drinking-water level (15:1)；Mulberry-leaf extract：Drinking-water level (20:1)；Aloe extract：
Drink water level, the barbaloin (UV) of content >=20%, the barbaloin (HPLC) of content >=10%；Dried orange peel extracts：Drinking-water level (10:1)；Mountain
Short, bristly hair or beard extract：Drinking-water level (10:1)：Licorice：Spice level (6:1), the glycyrrhizic acid (UV) of content >=10%, content >=2% is sweet
Oxalic acid (HPLC).
The present invention is by selecting a variety of natural plant extracts, with modern Chinese veterinarian's pharmacology opinion, reasonable disposition each component
With magnitude relation, gained feed addictive, which has, is obviously improved fowl poultry immune function, protection and reparation gastrointestinal mucosa barrier, raising machine
Body antioxidant levels, and then improve the overall production performance of livestock and poultry.
As the preferred embodiment of the present invention, the feed addictive is made by the raw material of following parts by weight：The Radix Astragali is carried
Take 100 parts of thing, 120 parts of Artemisinin, 110 parts of Radix Dichroae extract, 100 parts of Herba Agrimoniae extract, 70 parts of eucommia ulmoides extracts, Pu
Public 60 parts of English extract, 60 parts of atractylodes chinensis, 60 parts of mulberry-leaf extract, 70 parts of aloe extract, 80 parts of dried orange peel extracts, mountain
90 parts of short, bristly hair or beard extract, 80 parts of licorice.
Feed addictive of the present invention can be made using this area customary preparation methods.
The present invention also provides application of the above-mentioned feed addictive in feed.
Feed addictive of the present invention can be made into the regular dosage form that feed adds field, preferably pulvis or particle.
As the preferred embodiment of the present invention, the bead dosage form is made by the raw material of following parts by weight：Astragalus extraction
100 parts of thing, 120 parts of Artemisinin, 110 parts of Radix Dichroae extract, 100 parts of Herba Agrimoniae extract, 70 parts of eucommia ulmoides extracts, Pu Gong
60 parts of English extract, 60 parts of atractylodes chinensis, 60 parts of mulberry-leaf extract, 70 parts of aloe extract, 80 parts of dried orange peel extracts, hawthorn
90 parts of extract, 80 parts of licorice, 10 parts of binding agent, 10 parts of water.
Wherein, the binding agent is this area conven-tional adjuvants.It is preferred that cornstarch.
The bead dosage form is to add binding agent and/or excipient, water in proportion on the basis of above-mentioned feed addictive, is mixed
It is even, then through granulation, dry, sieving, produce.
Wherein, acceptable granule in feed can be made using oscillating granulation and fluid-bed drying in the bead dosage form
Type.
Feed addictive of the present invention addition in the feed of Sanhuang chicken, improve net gain, feed intake, feedstuff-meat ratio,
Advantage significantly, can more effectively improve Sanhuang chicken growth performance in terms of reducing death and culling rate, obtain unexpected effect.Wherein, pin
To the Sanhuang chicken of 1-14 ages in days, its addition is 200ppm；For the Sanhuang chicken of 15-50 ages in days, its addition is 150ppm.
Feed addictive of the present invention can effectively press down spore, the first generation and the second generation schizont of worm of killing, reduction
Its incidence of disease and avoid diseased region continue expand；Immunity of organism and premunition are improved simultaneously, and reduction cause of disease coccidia is to body
Infect；Protection and repair impaired gastrointestinal mucosa, promote the absorption of nutriment, with suppression kill worm, strengthen immunity, repair stomach
Enteron aisle triple function.；Green, environmental protection simultaneously, production method is easy, easy to operate, is adapted to widely popularize in animal husbandry.
Embodiment
Following examples are used to illustrate the present invention, but are not limited to the scope of the present invention.
In feed addictive of the present invention, the extract of each raw material can be obtained using field of Chinese medicines general extraction methods
Take, such as water extraction, alcohol extracting, it is also an option that commercially available each raw extract.Raw material is extracted in the present invention and is mainly purchased from Chengdu
Perseverance Easthome of city reaches bio tech ltd, and each extract active constituent content is as follows.Astragalus Root P.E：Content >=60-65%
Astragalus polyose (UV), content >=0.1-0.2% Astragaloside IVs (HPLC)；Artemisinin：Spice level (10:1)；Changshan is extracted
Thing：Drink water level, the orixine (UV) of content >=3%, the halofuginone hydrobromide (HPLC) of content >=0.5%；Herba Agrimoniae extract：Drinking-water level (15:
1)；Eucommia ulmoides extracts：Drink water level, the chlorogenic acid (HPLC) of content >=3%；Dandelion extract：Spice level (10:1), content >=
0.1% caffeic acid (HPLC)；Atractylodes chinensis：Drinking-water level (15:1)；Mulberry-leaf extract：Drinking-water level (20:1)；Aloe extract：
Drink water level, the barbaloin (UV) of content >=20%, the barbaloin (HPLC) of content >=10%；Dried orange peel extracts：Drinking-water level (10:1)；Mountain
Short, bristly hair or beard extract：Drinking-water level (10:1)：Licorice：Spice level (6:1), the glycyrrhizic acid (UV) of content >=10%, content >=2% is sweet
Oxalic acid (HPLC).
The feed addictive of embodiment 1
Formula：
Astragalus Root P.E 100kg, Artemisinin 120kg, Radix Dichroae extract 110kg, Herba Agrimoniae extract 100kg, Du
It is secondary extract 70kg, dandelion extract 60kg, atractylodes chinensis 60kg, mulberry-leaf extract 60kg, aloe extract 70kg, old
Bark extract 80kg, haw thorn extract 90kg, licorice 80kg.
The feed addictive of embodiment 2
Formula：
50 parts of Astragalus Root P.E, 50 parts of Artemisinin, 50 parts of Radix Dichroae extract, 50 parts of Herba Agrimoniae extract, the bark of eucommia are carried
50 parts of thing, 50 parts of dandelion extract, 50 parts of atractylodes chinensis, 50 parts of mulberry-leaf extract, 50 parts of aloe extract, dried orange peel is taken to carry
Take 50 parts of thing, 50 parts of haw thorn extract, 50 parts of licorice.
The feed addictive of embodiment 3
Formula：
80 parts of Astragalus Root P.E, 150 parts of Artemisinin, 150 parts of Radix Dichroae extract, 80 parts of Herba Agrimoniae extract, the bark of eucommia
100 parts of extract, 100 parts of dandelion extract, 100 parts of atractylodes chinensis, 100 parts of mulberry-leaf extract, aloe extract 100
Part, 100 parts of dried orange peel extracts, 100 parts of haw thorn extract, 100 parts of licorice.
The preparation method of the feed addictive of embodiment 4
According to the formula of embodiment 1, each raw material is poured into regulation mixer successively, starts mixer, is sufficiently mixed
Uniformly, incorporation time is 2 minutes, produces its powder product.
The preparation method of the feed addictive of embodiment 5
Method according to embodiment 4 prepares the feed addictive described in embodiment 2.
The preparation method of the feed addictive of embodiment 6
Method according to embodiment 4 prepares the feed addictive described in embodiment 3.
The feed addictive particle of embodiment 7
Formula：On the basis of being formulated described in embodiment 1, addition 10kg binding agents, 10kg water.
The preparation method of the feed addictive particle of embodiment 8
It is formulated, each component is mixed, then through oscillating granulation, fluidized bed drying, sieving according to described in embodiment 7, is produced
Granula type.
Influence of the experimental example 1 to Sanhuang chicken production performance
1 materials and methods
1.1 experimental animals and packet
Experiment is carried out in Animal Husbandry Inst., Guangdong Prov. Academy of Agricultural Sciences.
Experiment is randomly divided into 2 groups, every group of 4 repetitions are each to repeat 200 from the fast big Sanhuang chicken 1600 of 1 age in days.
Feed different daily rations (test process is shown in Table 1) respectively stage by stage, routinely program carries out feeding and management.
50 days experimental periods.
The test process of table 1
1.2 test events and method
1.2.1 test and weighed on an empty stomach at the end of, record feed intake and extremely naughty number calculate test chicken net gain, feeding
Amount, feed-weight ratio and death and culling rate.
1.3 statistical analyses
Experiment acquired results carry out variance analysis and Multiple range test with SAS statistical softwares.
2 result of the tests
Influence of the table 2 to Sanhuang chicken production performance
| Index | Control group | Embodiment 7 |
| Net gain (g/ is only) | 1648 | 1675 |
| Feed intake (g/ is only) | 3543 | 3551 |
| Feedstuff-meat ratio | 2.15 | 2.12 |
| Death and culling rate (%) | 11.2 | 9.5 |
As seen from Table 2, feed addictive granular preparation described in embodiment 7 improve net gain, feed intake, feedstuff-meat ratio, with
And had outstanding performance in terms of reduction death and culling rate, it was demonstrated that it can substitute the anticoccidial drug combination of control group completely, and more effective raising three is yellow
Chicken growth performance.
Experimental example 2 is to the effect applied in Sanhuang chicken daily ration
1 materials and methods
1.1 experimental animals and packet
Experiment is carried out in the large-scale Feed Enterprise plant in Guangdong.
The fast rheum officinale plumage cock (Sanhuang chicken) of 35~58 ages in days totally 1011 is selected in experiment, is divided into test group and control group totally 2
Group is carried out.
Test group is divided into 2 repetitions, repeats 1 cock 254, repeats 2 cock 253；Control group is divided into 2 repetitions, weight
Multiple 1 cock 251, repeats 2 cock 253.
Test period is in July, 2013~August.
Test process is shown in Table 3.
The test process of table 3
| Control group | Test group | |
| Chinese herb compound composition | Embodiment 7 | |
| Addition | 300g/T | 150g/T |
Note：Chinese herb compound composite formula：120 parts of sweet wormwood, 100 parts of hairyvein agrimony, 70 parts of setose thistle, 50 parts of the red sage root, dark plum
70 parts, 110 parts of Changshan, 80 parts of the Chinese bulbul, 80 parts of Radix Glycyrrhizae, 100 parts of the Radix Astragali, 100 parts of the root of herbaceous peony, it is standby that water extraction is dried to powder.
1.2 test events and method
1.2.1 test and weighed on an empty stomach at the end of, record feed intake and it is dead wash in a pan number, calculate test chicken net gain, feed intake,
The data such as feed-weight ratio.
1.3 statistical analyses
Experiment acquired results are calculated with SPSS statistical softwares.
2 result of the tests
Influence of the table 4 to Sanhuang chicken production performance
As can be seen from Table 4, feed addictive granular preparation compared with control group, improves survival rate described in embodiment 7,
Effect is also significantly reduced to feedstuff-meat ratio simultaneously, economic benefit is added, is worth promoting and uses.
Measure of merit is carried out to the granule that feed addictive obtained by embodiment 2-3 is made using above-mentioned experimental method, its
As a result it is basically identical.
Although above the present invention is described in detail with a general description of the specific embodiments,
On the basis of the present invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Cause
This, these modifications or improvements, belong to the scope of protection of present invention without departing from theon the basis of the spirit of the present invention.
Claims (8)
1. a kind of natural plants anticoccidial feed addictive, it is characterised in that be made by the raw material of following parts by weight：Astragalus extraction
50-100 parts of thing, 50-150 parts of Artemisinin, 50-150 parts of Radix Dichroae extract, 50-100 parts of Herba Agrimoniae extract, the bark of eucommia are carried
Take 50-100 parts of thing, 50-100 parts of dandelion extract, 50-100 parts of atractylodes chinensis, 50-100 parts of mulberry-leaf extract, aloe
50-100 parts of extract, 50-100 parts of dried orange peel extracts, 50-100 parts of haw thorn extract, 50-100 parts of licorice.
2. natural plants anticoccidial feed addictive according to claim 1, it is characterised in that by the original of following parts by weight
Material is made：100 parts of Astragalus Root P.E, 120 parts of Artemisinin, 110 parts of Radix Dichroae extract, 100 parts of Herba Agrimoniae extract, the bark of eucommia
70 parts of extract, 60 parts of dandelion extract, 60 parts of atractylodes chinensis, 60 parts of mulberry-leaf extract, 70 parts of aloe extract, dried orange peel
80 parts of extract, 90 parts of haw thorn extract, 80 parts of licorice.
3. natural plants anticoccidial feed addictive according to claim 1 or 2, it is characterised in that described natural plant
The formulation that feed is made in thing anticoccidial feed addictive is pulvis or particle.
4. natural plants anticoccidial feed addictive according to claim 3, it is characterised in that the granular preparation is by such as
The raw material of lower parts by weight is made：50-100 parts of Astragalus Root P.E, 50-150 parts of Artemisinin, 50-150 parts of Radix Dichroae extract,
50-100 parts of Herba Agrimoniae extract, 50-100 parts of eucommia ulmoides extracts, 50-100 parts of dandelion extract, atractylodes chinensis 50-100
Part, 50-100 parts of mulberry-leaf extract, 50-100 parts of aloe extract, 50-100 parts of dried orange peel extracts, haw thorn extract 50-100
Part, 50-100 parts of licorice, 10 parts of binding agent, 10 parts of water.
5. natural plants anticoccidial feed addictive according to claim 4, it is characterised in that the binding agent is selected from jade
Rice starch.
6. application of any described natural plants anticoccidial feed addictives of claim 1-5 in Sanhuang chicken feed.
7. application of the natural plants anticoccidial feed addictive according to claim 6 in Sanhuang chicken feed, its feature
It is that, for the Sanhuang chicken of 1-14 ages in days, its addition is 200ppm.
8. application of the natural plants anticoccidial feed addictive according to claim 6 in Sanhuang chicken feed, its feature
It is that, for the Sanhuang chicken of 15-50 ages in days, its addition is 150ppm.
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Families Citing this family (9)
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| CN104982667A (en) * | 2015-06-19 | 2015-10-21 | 安徽牧翔禽业有限公司 | Feed additive for preventing and treating coccidiosis in culture process of spotted-brown breeder chickens and preparation method thereof |
| CN105076761A (en) * | 2015-07-27 | 2015-11-25 | 王合平 | Local chicken feed |
| CN105831417A (en) * | 2016-05-31 | 2016-08-10 | 李加义 | Additive for laying hen feed |
| CN108902530A (en) * | 2018-07-19 | 2018-11-30 | 北京爱绿生物科技有限公司 | A kind of natural plants anticoccidial chicken feed addictive and its application |
| CN109100462B (en) * | 2018-09-26 | 2020-07-21 | 北京爱绿生物科技有限公司 | Thin-layer chromatography identification method for natural plant anticoccidial feed additive |
| CN109480087A (en) * | 2018-12-13 | 2019-03-19 | 双胞胎（集团）股份有限公司 | A kind of feed addictive of anticoccidial |
| CN109588555A (en) * | 2018-12-26 | 2019-04-09 | 北京爱绿生物科技有限公司 | A kind of water-soluble natural plants anticoccidial feed addictive and preparation method thereof |
| CN111084301B (en) * | 2019-12-30 | 2023-08-22 | 内江师范学院 | Mulberry leaf extract fish feed adhesive and preparation method and application thereof |
| CN112715789B (en) * | 2020-12-31 | 2023-11-07 | 内江师范学院 | Natural feed water-retaining agent composition and application thereof in fish feed |
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| CN102327338A (en) * | 2011-09-28 | 2012-01-25 | 广东紫金正天药业有限公司 | Rhubarb composition for treating chicken coccidiosis |
| CN103251858A (en) * | 2013-05-13 | 2013-08-21 | 安徽农业大学 | Traditional Chinese medicine composite for resisting parasite of free-ranging chicken and preparation method thereof |
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