CN109170224A - A kind of natural compounding type Chinese medicine fodder of substitute antibiotics - Google Patents

A kind of natural compounding type Chinese medicine fodder of substitute antibiotics Download PDF

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Publication number
CN109170224A
CN109170224A CN201811434116.0A CN201811434116A CN109170224A CN 109170224 A CN109170224 A CN 109170224A CN 201811434116 A CN201811434116 A CN 201811434116A CN 109170224 A CN109170224 A CN 109170224A
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chinese medicine
concentrate
substitute antibiotics
type chinese
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宗敏玲
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To Be Grown Up In Jiangxi Pharmaceutcal Corp Ltd
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To Be Grown Up In Jiangxi Pharmaceutcal Corp Ltd
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • A23K10/30Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K50/00Feeding-stuffs specially adapted for particular animals
    • A23K50/10Feeding-stuffs specially adapted for particular animals for ruminants
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K50/00Feeding-stuffs specially adapted for particular animals
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    • A61K36/287Chrysanthemum, e.g. daisy
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288Taraxacum (dandelion)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/35Caprifoliaceae (Honeysuckle family)
    • A61K36/355Lonicera (honeysuckle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/60Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605Morus (mulberry)
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/68Plantaginaceae (Plantain Family)
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/18Magnoliophyta (angiosperms)
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    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals

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Abstract

The invention discloses a kind of natural compounding type Chinese medicine fodders of substitute antibiotics, belong to composite feed technical field, the present invention by scientific and reasonable prescription, advanced extraction process, retain active ingredient of natural plant to the utmost, composite feed is improved to the antibacterial effect of germ, composite feed palatability obtained is good after mentioning natural plants slightly, and additive amount is low, effective antibacterial, antiviral effect, feeding antibiotic is substituted, cultivated animals disease incidence is reduced, promotes animal health growth.

Description

A kind of natural compounding type Chinese medicine fodder of substitute antibiotics
Technical field
The present invention relates to composite feed technical field, the natural compounding type Chinese medicine for more particularly relating to substitute antibiotics is raised Material.
Background technique
Feed is the general name of the food of owner domesticated animal, compares narrowly general feeds and generally refers to agricultural Or the food of animal husbandry domesticated animal.Feed include soybean, dregs of beans, corn, fish meal, amino acid, miscellaneous dregs of rice, additive, whey powder, The feedstuff of more than ten kinds such as grease, meat meal tankage, cereal, sugar grass.
With the enhancing of the health care consciousness of stock keeping industry, more and more raisers advocate not disease and first control, and focus on prevention Cultivation theory.The present invention is able to solve using antibiotic, the residue problems such as somatropin and drawback.Current cultivation industry is most urgent Cut problem to be solved: improve the disease resistances of livestock and poultry, coordinating intestines and stomach, enhancing appetite of livestock and poultry, the fertility for improving livestock and poultry, It reduces feedstuff-meat ratio, gradually decrease or even forbid antibiotic etc, this forces aquaculture using green additive to improve animal The quality of product.
Green additive refers to that having certain pharmacological property simultaneously generally can be mostly that medicine food is same as the natural plants of feedstuff The Chinese medicine in source, existing prevention and health care and the effect cured the disease, equally can also be used as diet, and this natural plants (Chinese medicine) can It is used as feedstuff, the disease resistance of livestock and poultry not only can be improved, moreover it is possible to greatly reduce antibiotic etc use.
The prior art all deposits quality standard, the palatability after the extraction process, extraction yield and extraction of natural plants In shortcoming, the active constituent content of product is low, additive amount is big, health care, control efficiency difference etc..
Existing natural plants divide dried object, crushed material, crude extract three categories, wherein the palatability of dried object and crushed material Difference, additive amount be big, effect slowly, impurity it is more, what part producing enterprise did is crude extract, but recovery rate is low, is difficult to point It is not scientific from purifying, being difficult to formulate quality standard, the easy moisture absorption (be unfavorable for and feed stirring is added), product formula, it is difficult to reach The effect of substitute antibiotics.
Animal feed is all directly to add various antibiotic at present, and effect is unobvious, and residual antibiotic does not meet country It is required that.
Summary of the invention
In order to overcome the drawbacks of the prior art, technical problem to be solved by the present invention lies in propose a kind of substitute antibiotics Natural compounding type Chinese medicine fodder, the present invention by scientific and reasonable prescription, advanced extraction process, retain day to the utmost Right effective ingredients in plant improves composite feed to the antibacterial effect of germ, natural plants is made slightly to mention rear composite feed obtained Expect that palatability is good, additive amount is low, effective antibacterial, antiviral effect, substitutes feeding antibiotic, reduces cultivated animals disease incidence, makes Product plays the antiviral effect of optimal antibacterial anti-inflammatory, promotes animal health growth.
To achieve this purpose, the present invention adopts the following technical scheme:
The present invention provides a kind of natural compounding type Chinese medicine fodder of substitute antibiotics, the natural compounding types of substitute antibiotics Chinese medicine fodder is made of the raw material of following mass fraction:
2-6 parts of cymose buckwheat rhizome, 4-9 parts of honeysuckle, 55-65 parts of purslane, 1-5 parts of poplar flower, 2-6 parts of dandelion, cordate houttuynia 15-25 parts, 8-12 parts of mulberry leaf, 2-6 parts of wild chrysanthemum, 3-9 parts of cimicifugae foetidae, 2-6 parts of Asiatic plantain and 4-9 parts of centella;
According to above-mentioned each raw material component, the natural compounding type Chinese medicine fodder of the substitute antibiotics is made by the following steps:
S1: taking cimicifugae foetidae, cymose buckwheat rhizome and wild chrysanthemum co-grinding, adds 40-50 DEG C of extraction 6- of 95% ethyl alcohol of 5-8 times of quality 7 hours, filtering obtained filtrate 1, the volume of filtrate 1 is concentrated by evaporation to the 30%-40% of original volume, obtains concentrate 1;
S2: poplar flower and dandelion co-grinding are added in the water of 6-10 times of quality, at 50-60 DEG C, 200W is micro- Wave extracts 30-40 minutes, filtrate decompression is concentrated into the 40-50% of original volume, obtains concentrate 2;
S3: by mulberry leaf and honeysuckle are cleaned, mulberry leaf go to obstruct, the heating, drying 60-100min at 30-40 DEG C, after drying Additive 1 is shredded to obtain, for use;
S4: concentrate 2 is uniformly mixed with additive 1,2-4h is stood at room temperature, obtains mixture 1;
S5: Asiatic plantain and centella are cleaned, mixing chopping, is added in the water of 10-16 times of quality, at 100 DEG C, holds Continuous heating 2-3h, takes filtrate after filtering, filtrate decompression is concentrated into the 20-30% of original volume, obtain concentrate 3;
S6: purslane and cordate houttuynia being cleaned, mixing chopping, and concentrate 1 and concentrate 3 are added, be uniformly mixed, 1-3h is stood at room temperature, obtains mixture 2;
S7: mixture 1 and mixture 2 being uniformly mixed and are added in extruder, are squeezed out pelletizing and obtained product.
In preferably technical solution of the invention, the natural compounding type Chinese medicine fodder of the substitute antibiotics is by following quality The raw material of number is made:
3-5 parts of cymose buckwheat rhizome, 6-8 parts of honeysuckle, 58-62 parts of purslane, 2-4 parts of poplar flower, 3-5 parts of dandelion, cordate houttuynia 18-22 parts, 9-11 parts of mulberry leaf, 3-5 parts of wild chrysanthemum, 6-8 parts of cimicifugae foetidae, 3-5 parts of Asiatic plantain and 6-8 parts of centella.
In preferably technical solution of the invention, the natural compounding type Chinese medicine fodder of the substitute antibiotics is by following quality The raw material of number is made:
4 parts of cymose buckwheat rhizome, 7 parts of honeysuckle, 60 parts of purslane, 3 parts of poplar flower, 4 parts of dandelion, 20 parts of cordate houttuynia, mulberry leaf 10 Part, 4 parts of wild chrysanthemum, 7 parts of cimicifugae foetidae, 4 parts of Asiatic plantain and 7 parts of centella.
In preferably technical solution of the invention, in the S1 step, cimicifugae foetidae, cymose buckwheat rhizome and wild chrysanthemum mixed powder are taken It is broken, add 45 DEG C of 95% ethyl alcohol of 6 times of quality to extract 6 hours, filtering obtains filtrate 1, the volume of filtrate 1 is concentrated by evaporation to substance Long-pending 35% obtains concentrate 1.
In preferably technical solution of the invention, in the S2 step, poplar flower and dandelion co-grinding are added In the water of 8 times of quality, at 55 DEG C, 200W Microwave Extraction 35 minutes, filtrate decompression is concentrated into the 45% of original volume, is obtained dense Contracting liquid 2.
In preferably technical solution of the invention, in the S3 step, by mulberry leaf and honeysuckle, clean, mulberry leaf go to obstruct, The heating, drying 80min at 35 DEG C shreds to obtain additive 1, for use after drying.
In preferably technical solution of the invention, in the S4 step, concentrate 2 is uniformly mixed with additive 1, in room Temperature is lower to stand 3h, obtains mixture 1.
In preferably technical solution of the invention, in the S5 step, Asiatic plantain and centella are cleaned, mixing is cut It is broken, it is added in the water of 13 times of quality, at 100 DEG C, continuous heating 2.5h takes filtrate after filtering, and filtrate decompression is concentrated into original The 25% of volume obtains concentrate 3.
In preferably technical solution of the invention, in the S6 step, purslane and cordate houttuynia are cleaned, mixing is cut It is broken, and concentrate 1 and concentrate 3 is added, it is uniformly mixed, stands 2h at room temperature, obtain mixture 2.
The invention has the benefit that
The natural compounding type Chinese medicine fodder of substitute antibiotics provided by the invention,
1. broad-spectrum antiseptic, the comprehensive feeding antibiotic for substituting anti-negative bacterium, anti-positive bacterium, comprehensive antibacterial, anti-inflammatory are reduced Animal morbidity.
2. pathogenic bacterial infection can be effectively suppressed for resisting for the livestock raised for meat fowl fattening later period, and deactivated before filling up the listing of livestock raised for meat fowl The blank phase after antibiotic improves meat product safety.
3. for egg fowl laying period whole process for anti-, raising egg product qualification rate, production " nonreactive egg ".
4. for the ruminants lactation period whole process such as milk cow, ewe for anti-, can effective prevention and control subclinical mastitis, improve fresh milk Quality produces " antibiotic-free milk ".
Specific embodiment
Below and pass through specific embodiment to further illustrate the technical scheme of the present invention.
Embodiment 1:
A kind of natural compounding type Chinese medicine fodder of substitute antibiotics is provided in embodiment 1,
The natural compounding type Chinese medicine fodder of substitute antibiotics is made of the raw material of following mass fraction:
2 parts of cymose buckwheat rhizome, 4 parts of honeysuckle, 55 parts of purslane, 1 part of poplar flower, 2 parts of dandelion, 15 parts of cordate houttuynia, mulberry leaf 8 Part, 2 parts of wild chrysanthemum, 3 parts of cimicifugae foetidae, 2 parts of Asiatic plantain and 4 parts of centella;
According to above-mentioned each raw material component, the natural compounding type Chinese medicine fodder of the substitute antibiotics is made by the following steps:
S1: taking cimicifugae foetidae, cymose buckwheat rhizome and wild chrysanthemum co-grinding, and 40 DEG C of 95% ethyl alcohol of 5 times of quality is added to extract 7 hours, Filtering, obtains filtrate 1, the volume of filtrate 1 is concentrated by evaporation to the 30% of original volume, obtain concentrate 1;
S2: poplar flower and dandelion co-grinding are added in the water of 6 times of quality, at 50 DEG C, 200W Microwave Extraction 30 minutes, filtrate decompression is concentrated into the 40% of original volume, obtains concentrate 2;
S3: by mulberry leaf and honeysuckle, clean, mulberry leaf go to obstruct, and the heating, drying 60min at 30 DEG C shreds to add after drying Charging 1, for use;
S4: concentrate 2 is uniformly mixed with additive 1,2h is stood at room temperature, obtains mixture 1;
S5: Asiatic plantain and centella are cleaned, mixing chopping, is added in the water of 10 times of quality, at 100 DEG C, continue 2h is heated, filtrate is taken after filtering, filtrate decompression is concentrated into the 20% of original volume, obtains concentrate 3;
S6: purslane and cordate houttuynia being cleaned, mixing chopping, and concentrate 1 and concentrate 3 are added, be uniformly mixed, 1h is stood at room temperature, obtains mixture 2;
S7: mixture 1 and mixture 2 being uniformly mixed and are added in extruder, are squeezed out pelletizing and obtained product.
Embodiment 2:
A kind of natural compounding type Chinese medicine fodder of substitute antibiotics is provided in embodiment 2,
The natural compounding type Chinese medicine fodder of substitute antibiotics is made of the raw material of following mass fraction:
4 parts of cymose buckwheat rhizome, 7 parts of honeysuckle, 60 parts of purslane, 3 parts of poplar flower, 4 parts of dandelion, 20 parts of cordate houttuynia, mulberry leaf 10 Part, 4 parts of wild chrysanthemum, 7 parts of cimicifugae foetidae, 4 parts of Asiatic plantain and 7 parts of centella;
According to above-mentioned each raw material component, the natural compounding type Chinese medicine fodder of the substitute antibiotics is made by the following steps:
S1: taking cimicifugae foetidae, cymose buckwheat rhizome and wild chrysanthemum co-grinding, and 45 DEG C of 95% ethyl alcohol of 6 times of quality is added to extract 6 hours, Filtering, obtains filtrate 1, the volume of filtrate 1 is concentrated by evaporation to the 35% of original volume, obtain concentrate 1;
S2: poplar flower and dandelion co-grinding are added in the water of 8 times of quality, at 55 DEG C, 200W Microwave Extraction 35 minutes, filtrate decompression is concentrated into the 45% of original volume, obtains concentrate 2;
S3: by mulberry leaf and honeysuckle, clean, mulberry leaf go to obstruct, and the heating, drying 80min at 35 DEG C shreds to add after drying Charging 1, for use;
S4: concentrate 2 is uniformly mixed with additive 1,3h is stood at room temperature, obtains mixture 1;
S5: Asiatic plantain and centella are cleaned, mixing chopping, is added in the water of 13 times of quality, at 100 DEG C, continue 2.5h is heated, filtrate is taken after filtering, filtrate decompression is concentrated into the 25% of original volume, obtains concentrate 3;
S6: purslane and cordate houttuynia being cleaned, mixing chopping, and concentrate 1 and concentrate 3 are added, be uniformly mixed, 2h is stood at room temperature, obtains mixture 2;
S7: mixture 1 and mixture 2 being uniformly mixed and are added in extruder, are squeezed out pelletizing and obtained product.
Embodiment 3
A kind of natural compounding type Chinese medicine fodder of substitute antibiotics is provided in embodiment 3,
The natural compounding type Chinese medicine fodder of substitute antibiotics is made of the raw material of following mass fraction:
6 parts of cymose buckwheat rhizome, 9 parts of honeysuckle, 65 parts of purslane, 5 parts of poplar flower, 6 parts of dandelion, 25 parts of cordate houttuynia, mulberry leaf 12 Part, 6 parts of wild chrysanthemum, 9 parts of cimicifugae foetidae, 6 parts of Asiatic plantain and 9 parts of centella;
According to above-mentioned each raw material component, the natural compounding type Chinese medicine fodder of the substitute antibiotics is made by the following steps:
S1: taking cimicifugae foetidae, cymose buckwheat rhizome and wild chrysanthemum co-grinding, and 50 DEG C of 95% ethyl alcohol of 8 times of quality is added to extract 7 hours, Filtering, obtains filtrate 1, the volume of filtrate 1 is concentrated by evaporation to the 40% of original volume, obtain concentrate 1;
S2: poplar flower and dandelion co-grinding are added in the water of 10 times of quality, and at 60 DEG C, 200W microwave is mentioned It takes 40 minutes, filtrate decompression is concentrated into the 50% of original volume, obtains concentrate 2;
S3: by mulberry leaf and honeysuckle, clean, mulberry leaf go to obstruct, and the heating, drying 100min at 40 DEG C is shredded after drying Additive 1, for use;
S4: concentrate 2 is uniformly mixed with additive 1,4h is stood at room temperature, obtains mixture 1;
S5: Asiatic plantain and centella are cleaned, mixing chopping, is added in the water of 16 times of quality, at 100 DEG C, continue 3h is heated, filtrate is taken after filtering, filtrate decompression is concentrated into the 30% of original volume, obtains concentrate 3;
S6: purslane and cordate houttuynia being cleaned, mixing chopping, and concentrate 1 and concentrate 3 are added, be uniformly mixed, 3h is stood at room temperature, obtains mixture 2;
S7: mixture 1 and mixture 2 being uniformly mixed and are added in extruder, are squeezed out pelletizing and obtained product.
Comparative test 1:
It chooses 1 age in days Guangdong Huang chick 1000 and is only used as test chicken, routinely method for breeding is raised to 21 ages in days.It therefrom selects again 500 healthy chicks out, 5 groups are divided into according to weight as homogeneously as possible, are denoted as blank control group, experimental group 1, experimental group respectively 2, experimental group 3 and experimental group 4, every group 100.Every chicken is fed according to daily 100g feed, wherein experimental group 1-3 points Compound Chinese medicine fodder made from embodiment 1-3, the proportion of compound Chinese medicine fodder and normal diet are not given by corresponding serial number For 3:7, experimental group 4 is fed using normal diet, but is needed that aureomycin is added from normal diet and be uniformly mixed, and is added Amount is 0.06g/100g.Blank control group is only given normal diet and is fed, other same experimental groups.After continuous feeding 3 days, To every group of chicken Escherichia Coli Injection, continue to feed, observe the incidence of chicken, occurs that loss of appetite, spirit is depressed, feather is loose Disorderly, phenomena such as having loose bowels, as falls ill.Calculate disease incidence.It the results are shown in Table 1.
Average daily gain (g) Disease incidence (%)
Experimental group 1 89 53
Experimental group 2 95 49
Experimental group 3 92 52
Experimental group 4 78 58
Control group 65 73
Comparative test 2:
It chooses the white Leghorn 500 that 150 ages in days or more have just been laid eggs and is only used as test chicken, divided as homogeneously as possible according to weight It is 5 groups, is denoted as blank control group, experimental group 1, experimental group 2, experimental group 3 and experimental group 4 respectively, every group 100, routinely raises The method raising of supporting continues to raise.Every chicken is fed according to daily 130g feed, wherein experimental group 1-3 gives respectively to be implemented The proportion of compound Chinese medicine fodder made from example 1-3, compound Chinese medicine fodder and normal diet is 3:7, and experimental group 4 is using common Feed is fed, but is needed that terramycin is added from normal diet and be uniformly mixed, additive amount 0.1g/kg.Blank control Group is only given normal diet and is fed, other same experimental groups.After continuous feeding 3 days, chicken Li Shi bar is injected to every group of chicken Bacterium continues to feed, and observes the incidence of chicken, and chicken phenomena such as cockscomb atrophy, diarrhea, loss of appetite occurs, as falls ill.It calculates Disease incidence;The produced egg of chicken after taking injection chicken Li bacillus at random, every group 10, according to GB/T 21317-2007 animal sources Property food in Tetracyclines residue of veterinary drug quantity measuring method, measure egg in oxytetracycline residues, it is mould to soil remaining in egg Element is measured, and is calculated Determination of oxytetracycline residues rate, be the results are shown in Table 2.
Comparative test 3:
The Fresian 50 chosen into the milk production phase is only used as test ox, is divided into 5 groups as homogeneously as possible according to weight, It is denoted as blank control group, experimental group 1, experimental group 2, experimental group 3 and experimental group 4 respectively, every group 10, routinely method for breeding is raised It supports and continues to raise.Every ox is fed according to daily 40kg feed, wherein experimental group 1-3 gives embodiment 1-3 respectively and is made Compound Chinese medicine fodder, the proportion of compound Chinese medicine fodder and normal diet is 3:7, and experimental group 4 is carried out using normal diet It feeds, but needs that aureomycin is added from normal diet and be uniformly mixed, additive amount 0.6g/kg.Blank control group is only given Normal diet is fed, other same experimental groups.After continuous feeding 3 days, to every group of beef injection ox Pasteurella, continue to raise Hello, the incidence of ox to be observed, bovine pasteurellosis often shows as acute septic, Edema Malnutrition, pneumonia type, when ox occurs in milk cow The symptom of pasteurellosis, as falls ill, and calculates disease incidence;Produced milk after taking injection bovine pasteurellosis 30 days malicious, often Head ox 1kg, according to the measuring method of aureomycin residual quantity in national standard GB29688-2013 national food safety standard milk, to ox Remaining aureomycin is measured in milk, is calculated aureomycin and is remained dose rate, the results are shown in Table 3.
The present invention is described with reference to the preferred embodiments, and those skilled in the art know, of the invention not departing from In the case where spirit and scope, various changes or equivalence replacement can be carried out to these features and embodiment.The present invention is not by this The limitation of specific embodiment disclosed in place, other embodiments fallen into claims hereof belong to protection of the present invention Range.

Claims (9)

1. a kind of natural compounding type Chinese medicine fodder of substitute antibiotics, it is characterised in that: in the natural compounding type of substitute antibiotics Medicine feed is made of the raw material of following mass fraction:
2-6 parts of cymose buckwheat rhizome, 4-9 parts of honeysuckle, 55-65 parts of purslane, 1-5 parts of poplar flower, 2-6 parts of dandelion, cordate houttuynia 15-25 Part, 8-12 parts of mulberry leaf, 2-6 parts of wild chrysanthemum, 3-9 parts of cimicifugae foetidae, 2-6 parts of Asiatic plantain and 4-9 parts of centella;
According to each raw material component, preparation step is as follows:
S1: taking cimicifugae foetidae, cymose buckwheat rhizome and wild chrysanthemum co-grinding, adds 40-50 DEG C of extraction 6-7 of 95% ethyl alcohol of 5-8 times of quality small When, filtering obtains filtrate 1, the volume of filtrate 1 is concentrated by evaporation to the 30%-40% of original volume, obtains concentrate 1;
S2: poplar flower and dandelion co-grinding are added in the water of 6-10 times of quality, at 50-60 DEG C, 200W microwave is mentioned It takes 30-40 minutes, filtrate decompression is concentrated into the 40-50% of original volume, obtain concentrate 2;
S3: by mulberry leaf and honeysuckle, clean, mulberry leaf go to obstruct, and the heating, drying 60-100min at 30-40 DEG C is shredded after drying Additive 1 is obtained, for use;
S4: concentrate 2 is uniformly mixed with additive 1,2-4h is stood at room temperature, obtains mixture 1;
S5: Asiatic plantain and centella being cleaned, mixing is shredded, and are added in the water of 10-16 times of quality, at 100 DEG C, persistently plus Hot 2-3h takes filtrate after filtering, filtrate decompression is concentrated into the 20-30% of original volume, obtains concentrate 3;
S6: purslane and cordate houttuynia are cleaned, mixing chopping, and concentrate 1 and concentrate 3 is added, be uniformly mixed, in room Temperature is lower to stand 1-3h, obtains mixture 2;
S7: mixture 1 and mixture 2 being uniformly mixed and are added in extruder, are squeezed out pelletizing and obtained product.
2. the natural compounding type Chinese medicine fodder of substitute antibiotics according to claim 1, it is characterised in that:
The natural compounding type Chinese medicine fodder of the substitute antibiotics is made of the raw material of following mass fraction:
3-5 parts of cymose buckwheat rhizome, 6-8 parts of honeysuckle, 58-62 parts of purslane, 2-4 parts of poplar flower, 3-5 parts of dandelion, cordate houttuynia 18-22 Part, 9-11 parts of mulberry leaf, 3-5 parts of wild chrysanthemum, 6-8 parts of cimicifugae foetidae, 3-5 parts of Asiatic plantain and 6-8 parts of centella.
3. the natural compounding type Chinese medicine fodder of substitute antibiotics according to claim 1, it is characterised in that:
The natural compounding type Chinese medicine fodder of the substitute antibiotics is made of the raw material of following mass fraction:
4 parts of cymose buckwheat rhizome, 7 parts of honeysuckle, 60 parts of purslane, 3 parts of poplar flower, 4 parts of dandelion, 20 parts of cordate houttuynia, 10 parts of mulberry leaf, open country 4 parts of chrysanthemum, 7 parts of cimicifugae foetidae, 4 parts of Asiatic plantain and 7 parts of centella.
4. the natural compounding type Chinese medicine fodder of substitute antibiotics according to claim 1, it is characterised in that:
In the S1 step, cimicifugae foetidae, cymose buckwheat rhizome and wild chrysanthemum co-grinding are taken, 45 DEG C of 95% ethyl alcohol of 6 times of quality is added to extract 6 Hour, filtering obtains filtrate 1, the volume of filtrate 1 is concentrated by evaporation to the 35% of original volume, obtains concentrate 1.
5. the natural compounding type Chinese medicine fodder of substitute antibiotics according to claim 1, it is characterised in that:
In the S2 step, poplar flower and dandelion co-grinding are added in the water of 8 times of quality, at 55 DEG C, 200W is micro- Wave extracts 35 minutes, and filtrate decompression is concentrated into the 45% of original volume, obtains concentrate 2.
6. the natural compounding type Chinese medicine fodder of substitute antibiotics according to claim 1, it is characterised in that:
In the S3 step, by mulberry leaf and honeysuckle, clean, mulberry leaf go to obstruct, and the heating, drying 80min at 35 DEG C is cut after drying It is broken to obtain additive 1, for use.
7. the natural compounding type Chinese medicine fodder of substitute antibiotics according to claim 1, it is characterised in that:
In the S4 step, concentrate 2 is uniformly mixed with additive 1,3h is stood at room temperature, obtains mixture 1.
8. the natural compounding type Chinese medicine fodder of substitute antibiotics according to claim 1, it is characterised in that:
In the S5 step, Asiatic plantain and centella are cleaned, mixing chopping, is added in the water of 13 times of quality, at 100 DEG C Under, continuous heating 2.5h takes filtrate after filtering, and filtrate decompression is concentrated into the 25% of original volume, obtains concentrate 3.
9. the natural compounding type Chinese medicine fodder of substitute antibiotics according to claim 1, it is characterised in that:
In the S6 step, purslane and cordate houttuynia are cleaned, mixing chopping, and concentrate 1 and concentrate 3 is added, mixes It closes uniformly, stands 2h at room temperature, obtain mixture 2.
CN201811434116.0A 2018-11-28 2018-11-28 A kind of natural compounding type Chinese medicine fodder of substitute antibiotics Pending CN109170224A (en)

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Application publication date: 20190111