CN103355483A - Compound Chinese herbal medicine extractive for replacing feed antibiotics - Google Patents
Compound Chinese herbal medicine extractive for replacing feed antibiotics Download PDFInfo
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- CN103355483A CN103355483A CN201310094832XA CN201310094832A CN103355483A CN 103355483 A CN103355483 A CN 103355483A CN 201310094832X A CN201310094832X A CN 201310094832XA CN 201310094832 A CN201310094832 A CN 201310094832A CN 103355483 A CN103355483 A CN 103355483A
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Abstract
The invention relates to the development of a compound Chinese herbal medicine extractive for replacing feed antibiotics. The extractive has the main advantages that (1) compound Chinese herbal medicines are 20% of Chinese gall, 15% of purslane, 15% of folium isatidis, 10% of wild chrysanthemum flower, 10% of cordate houttuynia, 8% of radix bupleuri, 8% of golden cypress, 7% of elsholtzia and 7% of dried radix rehmanniae which are combined; (2) the compound Chinese herbal medicine extractive has a selectivity antibacterial effect, namely, compared with aureomycin and flavomycin, the compound Chinese herbal medicine extractive has a stronger inhibiting effect on pathogenic bacteria such as escherichia coli and salmonella enteritidis, and compared with the aureomycin, the compound Chinese herbal medicine extractive has a weaker inhibiting effect on lactobacillus acidophilus and bifidobacterium animalis; (3) the compound Chinese herbal medicine extractive has a growth promotion effect on broilers, namely, both the extractive and the aureomycin can be used for increasing the daily gain and the survival rate of the broilers; (4) the compound Chinese herbal medicine extractive can be used for obviously improving the immune function of the broilers; and (5) the compound Chinese herbal medicine extractive can be used for improving the intestinal flora of the broilers and inhibiting the growth of escherichia coli in intestinal tracts and does not affect the growth of lactic acid bacteria in the intestinal tracts.
Description
Technical field
The present invention relates to a kind of development of extract of compound Chinese herb of alternative feeding antibiotic, belong to the field of Chinese medicines.
Background technology
Add antibiotic in the feed and can promote that this phenomenon of growth of animal is that American scientist was found in 1945, afterwards, antibiotic just little by little extensively was used in the feed in the whole world, and animal husbandry development is played certain impetus.Yet the drawback of the long-term unreasonable use of antibiotic manifests day by day, not only causes in livestock products and the environment antibiotic residue problem that exceeds standard, and has also increased the drug-fast generation frequency of pathogen, makes the immunity degradation of fowl poultry body.It is to be noted especially, though antibiotic has the antimicrobial spectrum of oneself, also can affect profitable strain growth in the body when it acts on pathogen.Feed industry, aquaculture are because the feeding antibiotic low price at present, steady quality, successful is still in a large amount of uses, it uses still difficult the realization in a short time total ban, but this just more demonstrates searching energy substitute antibiotics, and non-harmful green additive becomes the task of top priority of the nuisanceless livestock products of China.Chinese herbal medicine as feed addictive in the history in existing several thousand of China,, noresidue safe and effective because of it, have no side effect, characteristics pollution-free and that have immunoloregulation function concurrently are just showing its unique advantage and development prospect.In the prior art, application number is that the Chinese patent application of CN2010105821853 discloses the patent documentation of a kind of " Chinese herbal feed additive ", this additive is with duckweed 700g-600g, three-coloured amaranth 500g-400g, Radix Glycyrrhizae 200g-150g, dandelion 15g-10g, ganoderma lucidum fermented liquid 400ml-350ml, fermentation liquid of Poria cocos 400ml-350ml makes, add letting animals feed to after allowing it edible in the feed by the weight ratio of 0.5%-1%, can improve food conversion ratio and the speed of growth of animal, improve immunity function, prevent disease occurs.Application number is that the Chinese patent application of CN2011101117894 discloses the patent documentation of a kind of " Chinese medicinal herb additive for meat chickens and preparation method thereof " by name, this additive is by folium cortex eucommiae, hawthorn powder, honeysuckle, the Radix Isatidis leaf, the raw materials such as the root of large-flowered skullcap form, and successively by selecting materials, the moon dries in the air, classification is pulverized, stir, make feed addictive after the packing, have pleasant helping digestion, calmness composes oneself, heat reliving and toxin-eliminating, the functions such as bactericidal antiphlogistic, can promote animal metabolism, strengthen the resistance against diseases of broiler chicken, improve food conversion ratio, promote growth of meat chicken, improve feeding environment.Application number is that the Chinese patent application of CN2012100750723 discloses the patent documentation of a kind of " first feed addictive of the little ecological symphysis of Chinese herbal medicine and preparation method thereof and utilization " by name, this additive is comprised of little ecological symphysis unit's feed addictive and Chinese herbal feed additive, can improve animal-breeding production efficiency, reduce feeding cost, strengthen immunity and the anti-stress ability of animal, reducing sickness rate.Application number is that the Chinese patent application of CN2012100426166 discloses the patent documentation of a kind of " improving Chinese herbal feed additive and the using method thereof of chicken immunity prevention diarrhoea " by name, this feed addictive is with the fleece-flower root, barrenwort, Radix Codonopsis, the bighead atractylodes rhizome, Poria cocos, the coptis, golden cypress, the root of large-flowered skullcap, the seed of Oriental arborvitae, jujube kernel, Radix Angelicae Sinensis, Chinese herbaceous peony, the banksia rose, stir-baked MASSA FERMENTATA MEDICI-NALIS, melanoidin malt, charred FRUCTUS CRATAEGI, keel, oyster, betel nut, rhizome of cyrtomium, Radix Glycyrrhizae is raw material, through screening, drying and crushing, mixing packing forms, for building up health, improve immunity of organisms, strengthen body to the resistance of pathogenic microorganism, reduce the good effect that plays of disease.
The major defect that above several patent exists has related to Chinese herbal feed additive fowl dirty swine product performance, immunity function has been reached the action effect to pathogenic microorganism, and do not consider that it to fowl poultry gut flora balance, especially lacks the contrast effect with feeding antibiotic.
Summary of the invention
The present invention relates to a kind of development of compound Chinese herb extract of alternative feeding antibiotic, obtain a kind ofly can not only improving broiler chicken daily gain, survival rate, immunologic function, and can improve the compound Chinese herb extract of Intestine of Broiler flora, can be achieved by the following technical programs.Mainly contain following steps:
(1) compound Chinese herb compatibility: Chinese gall, purslane, folium isatidis, mother chrysanthemum, cordate houttuynia, radix bupleuri, golden cypress, elscholtiza, the dried rhizome of rehmannia;
(2) compound Chinese herb extract preparation.Water extraction is processed, the little fiery boiling liquid of sonic oscillation through soaking by a certain percentage, continues to keep slight boiling condition.The dregs of a decoction carry out the secondary water extraction, and method is the same;
(3) the selective bacteriostatic test of compound Chinese herb extract.Mainly observe it to pathogenic bacteria-Escherichia coli, Bacterium enteritidis, salmonella typhimurium, staphylococcus aureus, and beneficial bacteria of intestinal tract-lactobacillus acidophilus, animal bifidobacteria affects on the growth, and compare with feeding antibiotics such as aureomycin, flavomycoins;
(4) the compound Chinese herb extract is on the impact of growth of meat chicken growth;
(5) the compound Chinese herb extract is on the impact of broiler chicken immunologic function;
(6) the compound Chinese herb extract is to the improvement effect of Intestine of Broiler flora;
(7) result shows, the compound Chinese herb extract is compared better effects if to the In-vitro Inhibitory Effect of pathogenic bacteria with feeding antibiotic, and than aureomycin to the inhibition strength of probio a little less than some, but slightly inferior to flavomycoin; The compound Chinese herb extract can improve daily gain and the survival rate of Luo Si broiler chicken, and is suitable with the feeding antibiotic comparative effectiveness; The compound Chinese herb extract particularly is significantly improved to thymus index and spleen lymphocyte proliferation ability to Immune Organs Index, the newcastle epidemic disease antibody of the broiler chicken effect that improves of tiring, and will get well than the feeding antibiotic effect; But Escherichia coli in the compound Chinese herb extract establishment Intestine of Broiler and on the not impact of growth of lactic acid bacteria, and feeding antibiotic has been broken the balance of gut flora, not only Escherichia coli is had inhibitory action, and lactic acid bacteria is also had strong inhibitory action.All in all, compound Chinese herb extract action effect is better than feeding antibiotic, therefore this compound Chinese herb extract can substitute feeding antibiotic use aborning.
Advantage of the present invention is:
(1) because the strong bacteriostasis of feeding antibiotic, growth that not only can the establishment various pathogens, and the inhibitory action to beneficial bacteria of intestinal tract is strong equally, particularly long-term a large amount of the use causes flora imbalance in the body, microecological balance destroys, and compound Chinese herb has some improvement to Intestine of Broiler flora tool, suppresses Escherichia coli and on the not impact of growth of lactic acid bacteria;
(2) the compound Chinese herb extract can improve daily gain and the survival rate of Luo Si broiler chicken, and is suitable with the feeding antibiotic comparative effectiveness;
(3) the compound Chinese herb extract is to Immune Organs Index, the newcastle epidemic disease antibody of the broiler chicken effect that improves of tiring, particularly thymus index and spleen lymphocyte proliferation ability are significantly improved, and feeding antibiotic is without the effect that strengthens human body immune function.
Claims (6)
1. the extract of the compound Chinese herb of an alternative feeding antibiotic is characterized in that: the compound Chinese herb compatibility: Chinese gall 20%, purslane 15%, folium isatidis 15%, mother chrysanthemum 10%, cordate houttuynia 10%, radix bupleuri 8%, golden cypress 8%, elscholtiza 7%, the dried rhizome of rehmannia 7%.
2. the extract of the compound Chinese herb of a kind of alternative feeding antibiotic as claimed in claim 1, it is characterized in that: this extract is to Escherichia coli, Bacterium enteritidis, salmonella typhimurium, staphylococcus aureus, and the selective inhibitory of animal lactobacillus acidophilus, bifidobacterium growth, and compare with feeding antibiotics such as aureomycin, flavomycoins.
3. the extract of the compound Chinese herb of a kind of alternative feeding antibiotic as claimed in claim 1 is characterized in that: by the method that drinking-water mixes, observe this extract to the impact of the growth performance of broiler chicken.
4. the extract of the compound Chinese herb of a kind of alternative feeding antibiotic as claimed in claim 1 is characterized in that: by Immune Organs Index, newcastle epidemic disease antibody tire, this extract of evaluation of measuring of spleen lymphocyte proliferation conversion capability is on the impact of the immunity function of broiler chicken.
5. the extract of the compound Chinese herb of a kind of alternative feeding antibiotic as claimed in claim 1, it is characterized in that: this extract is to the selective inhibitory of Escherichia coli in the Intestine of Broiler and lactic acid bacteria.
6. the extract of the compound Chinese herb of a kind of alternative feeding antibiotic as claimed in claim 1, it is characterized in that: this extract external selectively antibacterial, improve immune functions in broiler chickens and improve the aspect such as gut flora and all be better than flavomycoin or aureomycin, promote on the growth of meat chicken suitable with the aureomycin effect.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201310094832XA CN103355483A (en) | 2013-03-25 | 2013-03-25 | Compound Chinese herbal medicine extractive for replacing feed antibiotics |
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| CN201310094832XA CN103355483A (en) | 2013-03-25 | 2013-03-25 | Compound Chinese herbal medicine extractive for replacing feed antibiotics |
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| CN103355483A true CN103355483A (en) | 2013-10-23 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103652488A (en) * | 2013-12-12 | 2014-03-26 | 沙河市示范饲料厂 | Compound feed for laying hens |
| CN105146099A (en) * | 2015-10-29 | 2015-12-16 | 崔永进 | Poultry feed additive for replacing antibiotics and promoting growth |
| CN108041323A (en) * | 2017-12-07 | 2018-05-18 | 重庆凌丰科技有限公司 | It is a kind of to be used to treat mixed feed of fowl typhoid and preparation method thereof |
| CN109170224A (en) * | 2018-11-28 | 2019-01-11 | 江西中成人药业有限公司 | A kind of natural compounding type Chinese medicine fodder of substitute antibiotics |
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| CN102451282A (en) * | 2010-11-01 | 2012-05-16 | 梁杰 | Antiviral additive and preparation method thereof |
| CN102526375A (en) * | 2012-02-03 | 2012-07-04 | 天津赛普瑞斯科技有限公司 | High-fever-disease resistance Chinese herbal medicine composition for feed |
| CN102552525A (en) * | 2012-01-12 | 2012-07-11 | 河北农业大学 | Development of Chinese medicinal herb formula with selective anti-bacteria effect |
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2013
- 2013-03-25 CN CN201310094832XA patent/CN103355483A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102451282A (en) * | 2010-11-01 | 2012-05-16 | 梁杰 | Antiviral additive and preparation method thereof |
| CN102552525A (en) * | 2012-01-12 | 2012-07-11 | 河北农业大学 | Development of Chinese medicinal herb formula with selective anti-bacteria effect |
| CN102526375A (en) * | 2012-02-03 | 2012-07-04 | 天津赛普瑞斯科技有限公司 | High-fever-disease resistance Chinese herbal medicine composition for feed |
Non-Patent Citations (1)
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| 陈虹等: "12种中草药对8种畜禽肠道病原菌的体外抑菌试验", 《甘肃农业大学学报》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103652488A (en) * | 2013-12-12 | 2014-03-26 | 沙河市示范饲料厂 | Compound feed for laying hens |
| CN105146099A (en) * | 2015-10-29 | 2015-12-16 | 崔永进 | Poultry feed additive for replacing antibiotics and promoting growth |
| CN108041323A (en) * | 2017-12-07 | 2018-05-18 | 重庆凌丰科技有限公司 | It is a kind of to be used to treat mixed feed of fowl typhoid and preparation method thereof |
| CN109170224A (en) * | 2018-11-28 | 2019-01-11 | 江西中成人药业有限公司 | A kind of natural compounding type Chinese medicine fodder of substitute antibiotics |
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Application publication date: 20131023 |