CN1935182A - Chinese herbal medicine compound immunopotentiator for animal - Google Patents

Abstract

The present invention relates to a new type Chinese medicine compound preparation which can be used as animal immunopotentiator and animal health-care product. Said preparation is formed from the Chinese medicinal materials of bupleurum root, astragalus root, ledebouriella root, codonopsis root, epimedium isatis leaft, lonicera steam and leaf and humic acid.

Description

The Chinese herb compound animal immunity potentiator

Technical field

The invention belongs to technical field of Chinese medicines.Be specifically related to a kind of Chinese herb compound animal immunity potentiator.

Background technology

Hamuro etc. (1988) have reported the immunologic function mechanism of effective active compositions such as pachyman, hydroxyethyl pachyman 23, hydroxyethyl pachyman 24, methylol pachyman.Clayton (1999) proposes, there is more science the behind of botanical, and Australian scientist succeeds in developing natural plant products such as steyregg, delacon and biotechnik, and this series products can improve the fertility performance of animal, facilitating digestion improves effects such as premunition.The effective ingredient that Tsinas (1999) report extracts from origanum has the effect of very strong antibiotic, antioxidation and enhancement animal appetite, and piglet diarrhea is had good therapeutical effect.EU countries begins to advocate energetically use natural drug feed additive, and has strengthened its research is dropped into.FDA (FDA) has carried out preliminary study with regard to how managing this series products, thinks that Chinese herbal medicine has the effect of promoting animal health, should belong to animal health nutrition category.The application of Chinese herbal feed additive in aquaculture develops.

So far, have 200 at least surplus kind of a Chinese herbal medicine apply to aquaculture.For example

Application in Swine Production

Zhang Lihua nineteen ninety reports that Maifanitum PM S feed additive can make the piglet daily gain improve 13.98%, and feed conversion rate improves 9.19%.Pass moral report in 1991 Wei and count the pH Chinese herbal medicine that the flavor Chinese herbal medicine is formed, can make weight gain of piglets speed improve 21.36%, improved efficiency of feed utilization, every kilogram of weightening finish cost reduction by 14.28% with Fructus Hordei Germinatus, Radix Polygoni Multiflori, Bulbus Allii, Pericarpium Citri Reticulatae, Folium Pini, Cortex Fraxini etc.Yuan Fuhan etc. add 5% Folium paulowniae in pig feed, can improve weightening finish 20.5%, and the price of deed improves 9.7%, and the effect of obvious appetite strengthening and premunition is arranged.Shi Renbo adds 3% Herba Portulacae powder in the feedstuff of nursing sow, can make the weight of weaning litter of pig improve 30%, and sickness rate and case fatality rate reduce by 65% and 48% respectively.Meng Zhaoju raises pigs as additive with the single astragalus membranaceus powder, and addition is 1% of a daily ration, and daily gain improves 23.6% than matched group as a result, and breeding cycle shortens 17d, and feed conversion rate improves 13.3%, and economic benefit increases by 41%.Long flourish 2002 of Pueraria lobota is associated with the Radix Astragali, Rhizoma Coptidis, Radix Et Rhizoma Rhei, Cortex Albiziae, Rhizoma Osmundae, Poria and makes additive, select 160 of " DLY " tri-crossbreedings about 20kg for use, divide 3 stages to carry out feeding experiment, the result shows: this additive can obviously improve growth performance and the food utilization efficiency of store pig, and can prevent effectively that 20～30kg piglet from suffering from diarrhoea.Add the piglet of in feedstuff, feeding with Folium Hippophae 2%, can increase weight 9.38%～21.27%; Add 1.5% gypsum powder summer in piglet diet, can improve weightening finish 7%; Fructus Crataegi 25g, Fructus Hordei Germinatus 30g, Radix Gentianae 12g, Radix Et Rhizoma Rhei 6g, Massa Medicata Fermentata 25g have growth promoting function to cad pig.Hou Yongqing 2003 is with Chinese herbal medicine crude drugs such as the Radix Pulsatillae, Adeps Bovis seu Bubalis, the extraction process that adopts organic solvent extraction method and decocting cooking method to combine, make powder after extracting solution concentrated, in the 35d piglet diet, add 0.1%, the result shows that the Chinese herbal medicine extracting agent is to improving daily gain, improving efficiency of feed utilization has certain effect, and 0.01% (by effective ingredient) chlortetracycline effect is suitable with adding.And for example:

Application in the cowboying sheep produces

During producing, herding once reported the Chinese herbal medicine additive prescription of the milk that do not reduce.Grandson keeps and chisels report in 1997, add freshly-slaughtered poultry hat scape leaf 5～6kg in the dairy cow diet, average daily milk production improves 16%～18%, butterfat percnetage improves usefulness Folium Hippophae such as 1.8% left and right sides Guo Fucun and Fructus Hippophae sarcocarp slag as the feed additive milk goat of feeding, the result makes the milk yield of milk goat improve 3.2%～6.88%, feed conversion rate improves 4.55%～8.4%, and the milk composition is identical with common milk with edibility.The Chen Huiyun report is made into " the increasing breast looses " milk goat of feeding with Semen Vaccariae, the Radix Astragali, Herba Taraxaci, Massa Medicata Fermentata, Fructus Anisi Stellati, sodium carbonate etc., and every increases newborn 4.1kg.The Zhou Jiyong report can significantly reduce total lipids, cholesterol, triglyceride, ketoboidies level by herbal prescriptions such as Radix Codonopsis, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Dipsaci, Radix Glycyrrhizae, Radix Bupleuri, the Rhizoma Atractylodis Macrocephalaes, and can suppress the formation of fatty liver.Add Cacumen Platycladi the calf feed intake is significantly increased, add the 71g Gypsum Fibrosum in dairy cow diet, can improve milk yield 2%, every kilogram of feed consumption reduces by 11%, feeds cattle with 1: 1 preserved material of Radix Et Caulis Acanthopanacis Senticosi, can improve milk yield 10%～21.6%.Also just like:

Application in the production of raising chickens: wear prestige far away report in 1997, traditional tonic medicine can promote the growth of chickling immune organ, thereby significantly improves the immunocompetence of body.Zhang Liyun calendar year 2001 reports with the Yinqiao detoxification mixture and feeds 10 monthly age of drink chicken that the result can significantly improve chicken T lymhocyte transformation rate, can significantly improve the non-specific cell immunologic function of its body.The Huo Shuying report waits and add pure Chinese medicine feed additive in the broiler chicken daily ration, and the gaining effect of chicken is remarkable.The Sun Shouzhuo report is fed chickling with the Flos Celosiae Cristatae seed, and 1～2g, daily gain improves 20%, and can prevent the white scour of chicken; Add 5% Flos Celosiae Cristatae seed in the broiler fodder, meat yield improves 15%; Add 6% Flos Celosiae Cristatae seed in the laying ration and can replace 2% imported fish meal and 4% soybean cake, egg production improves 14%, and feeding cost reduces by 8.5%.The Guo Fucun report is made into compound additive with Maifanitum, Folium Hippophae and can makes laying rate of laying hen improve 31.44%.Yuan Fuhan once formed Chinese herbal feed additive with Fructus Capsici, Gypsum Fibrosum, Rhizoma Atractylodis, the Radix Astragali, Pericarpium Citri Reticulatae etc., with 1% addition, the 419 age in days laying hens of feeding, the result shows, laying rate improves 7.33%, feed conversion rate improves 9.15%, rate of broken eggs reduces 73.7%, and yolk color (1～8 week) improves 3.1 grades.Zhao Jianhua utilizes the single astragalus membranaceus powder Yi Sha laying hen of feeding, and the result shows that test group reduces by 4% than the matched group mortality rate, and laying rate improves 7.3%, and feedstuff-egg ratio reduces by 0.14.

Chinese herbal medicine is as the existing more research of feed additive, but owing to fail to set about from Basic Theories of Chinese Medicine, according to raising the actual dialectical Analyses (opinion is controlled) of carrying out, therefore a lot of people only note the major function of medicine on herbal prescription, so do not obtain the effect envisioned as yet; On the other hand, because the specificity of Chinese herbal medicine is relatively poor relatively, the time of onset is relatively slow again, and is that adjustment, Yin Yang balancing are main, and in the anti-use of the large-scale group of intensification, consumption is bigger than normal, and quality index is difficult to control.

Summary of the invention

Technical problem to be solved by this invention is to provide a kind of Chinese herb compound feed additive that can effectively improve the resistance against diseases of pig and promote growth.

The invention provides a kind of Chinese herb compound animal immunity potentiator (AM51), said preparation is made up of following components in weight percentage:

The herbal component consumption

Radix Bupleuri 5～20

The Radix Astragali 5～20

Radix Saposhnikoviae 1～15

Radix Codonopsis 5～20

Herba Epimedii 1～15

Folium Isatidis 5～20

Caulis Lonicerae 5～30

Folium Acanthopanacis Senticosi 5～20

Humic acids 0.1～2.0

Above Chinese medicine is 100g altogether.

In the preparation of the present invention Radix Bupleuri tool dispelling wind bring down a fever, the effect of regulating functional activities of qi, mainly contain three be greedy for food, terpene saponins, polysaccharide, phenolic acids, volatile oil material, except that resisting pathogenic microbes, analgesic, antiinflammatory, analgesia, stronger the exempt from service potentiation and the regulating action of exempting from service are arranged.Radix Astragali invigorating QI to consolidate the body surface resistance, invigorating middle warmer invigorating the spleen and benefiting QI, it contains flavonoid, saponins, polysaccharose substance can improve the body ability of exempting from service, add that Radix Saposhnikoviae more can effectively play exempt from service adjusting anti-peroxidation and antidotal effect, stem and leaf of Radix Et Caulis Acanthopanacis Senticosi, Radix Codonopsis, contain the ginsenoside and polysaccharide all can improve the level of exempting from service, play the effect of preventing and curing diseases.Folium Isatidis Radix Isatidis heat-clearing and toxic substances removing is effectively resisted pathogenic microorganism, and especially viral infection just share effectively to play entirely and prevents and cures diseases, and strengthens the effect of the power of exempting from service.Add micro-humic acids and can greatly improve the drug effect level, play the effect of Synergistic.

The preparation of preparation of the present invention is above-mentioned Chinese medicine water decoction-alcohol sedimentation to be crossed 80 mesh sieves with after drying add feedstuff, and use amount is; 5% of forage volume gets final product.Above compound recipe is according to the characteristic of Chinese herbal medicine itself, adopt directed microwave leaching technology, modes such as utilization water is carried, alcohol extraction, ester are carried are come out the extracts active ingredients of Chinese herbal medicine, and using the spray drying mode again carries out effective ingredient farthest to concentrate, and makes the Chinese herb compound essence and obtains through refining agent.

Chinese herb compound essence of the present invention is obtained through refining agent AM-51Effect in livestock and poultry cultivation.

By large-scale experiment, popularization and the application that comes 3 years, on producing, animals such as chicken, duck, pig and milch cow having obtained very great achievement more.

1, broiler

1. disease-resistant growth-promoting improves survival rate, improves and delivers body weight for sale; 2. anti-stress reduces the respiratory tract puzzlement; 3. improve the vaccine immune response ability, improve antibody titer; 4. regulate function of intestinal canal, minimizing is suffered from diarrhoea and is had loose bowels.

2, laying hen

1. improve and brood, breed adult livability, reduce the laying period death rate, to bacterial disease such as escherichia coli, Pullorum Disease and newcastle, biography prop up, virosis such as influenza has the auxiliary treatment effect.Use novel Chinese herb compound essence to obtain through refining agent AM-51---after 2000, laying period death rate drop to 10% with interior (7%～10%) by original 12%～15%.The peritonitis that minimizing escherichia coli, Salmonella are brought out, Pullorum Disease etc.Partially or completely replace antibiotic, improve the price of deed, improve egg material ratio.

2. prolong the peak of laying eggs, can make egg drop reduction reduce about 0.8%, improve the quality of egg.

3. anti-stress, alleviate the egg drop reduction that burst factor (antibacterial, virus and other) causes, quicken the recovery of disease chicken fertility performance, reduce the various harm that heat stress causes.

3, plant chicken

1. add 1 ‰ in feedstuff, can improve kind of a chicken fertility performance, rate of fertilization improves 2%, and incubation rate improves 1%, and strong young rate improves 1%～3%, reduces special-shaped egg, husky preserved egg.Aggregative index can make an interplanting chicken increase by 10 offsprings, and input-output ratio can reach (1: 10)～(1: 20).

2. human body immunity improving power and anti-stress ability reduce the peritonitis that the artificial insemination misoperation causes, diseases such as control Salmonella, colibacillosis.

4, duck

1. strengthen premunition, improve the stage survival rate of brooding, suppress the eruption and prevalence of antibacterial, virosis.Overcome a little less than the early immune function, the immunity of vaccine such as duck viral hepatitis etc. is had tangible potentiation.

2. prolong the peak of laying eggs of duck, recover the color of eggshell, deepen the color of egg yolk.

3. anti-stress, the egg drop reduction of avoiding burst factor such as intense stimulus such as hot and cold to cause.

5, pig

Spice feedstuff 1kg per ton (additive), drinking-water 0.4kg (soluble powder) can produce obvious influence to the health of pig.

1. piglets, baby pig diarrhoea there are the obvious suppression effect, thereby improve the survival rate of piglets, piglet.

2. improve specificity and the non-specific immunity of pig, strengthen the premunition of pig, can partly substitute antibiotic, reduce the appearance and the drug cost of Resistant strain.

3. many swine diseasess such as flu, colibacillosis, asthma, transmissible gastroenteritis etc. had the auxiliary treatment effect.

4. improve the cholesterol level of meat quality, reduction meat products.

5. boar is had the anti-heat stress effect, keep and search for food and milk yield.

Novel Chinese herb compound essence is obtained through refining agent AM-51To common animals treatment of diseases solution.

1, influenza: special 0.1% drinking-water of anti-sense rice, logotype 3～5d cooperates 0.2% novel Chinese herb compound essence to obtain through refining agent AM-51Spice 5d.After stable, 0.1% novel Chinese herb compound essence is obtained through refining agent AM-51Logotype 10d.

2, the intramuscular injection of 2 times of amounts of newcastle: LaSota cooperates 0.2% novel Chinese herb compound essence to obtain through refining agent AM-51Spice logotype 5d.

3, infectious bursal disease:, cooperate 0.2% novel Chinese herb compound essence to obtain through refining agent with 2 times of amount injections of fabricius bursa Seedling AM-51Spice, logotype 5d.

4, renal type infectious bronchitis:, cooperate 0.2% novel Chinese herb compound essence to obtain through refining agent simultaneously with Clone30+H120+28/86 Seedling eye dripping alive, collunarium AM-51Spice, logotype 5d.

5, infectious bronchitis: add novel Chinese herb compound essence by 0.1%～0.2% amount and obtain through refining agent AM-51, logotype 5d.

6, stress: add novel Chinese herb compound essence by 0.1% and obtain through refining agent AM-51Spice, logotype 5d is as long-term interpolation, better effects if.

7, colibacillosis:, add 0.2% novel Chinese herb compound essence and obtain through refining agent with in the antibacterial drug therapy AM-51, logotype 5d.

The main effect of preparation of the present invention has:

1. antibacterial, antiviral; 2. quicken, strengthen immune response; 3. improve anti-stress ability, avoid changeing group, transportation, immunity inoculation and hot and coldly stress wait the influence that causes; 4. improve the feed intake growth promotion, improve feedstuff-meat ratio, expect that milk compares; 5. improve environment: reduce stressors, reduce the discharging of ammonia, hydrogen sulfide and pathogen.In sum, novel Chinese herb compound essence is obtained through refining agent AM-51Be a kind of pure natural, noresidue, have no drug resistance, do not have withdrawal time, no incompatibility, pollution-free, the pure natural animal health product that have no side effect, have characteristics such as stable performance, high temperature resistant, self mildew-resistant, antioxidation.

The specific embodiment

Embodiment one:

Herbal component consumption (percentage by weight)

Component A Radix Bupleuri 13

The Radix Astragali 13

Radix Saposhnikoviae 7

Radix Codonopsis 13

Herba Epimedii 7

Folium Isatidis 13

Caulis Lonicerae 19.7

Folium Acanthopanacis Senticosi 13

B component humic acids 0.3

Preparation method:

1. after the Chinese herbal medicine of respectively distinguishing the flavor of among the component A being mixed, behind water extract-alcohol precipitation, cross 100 mesh sieves;

2. B component is added among the A, mix until evenly;

When 3. using, mixed phase sneaked in the feedstuff according to 5% of forage compounding get final product.

Embodiment two:

Herbal component consumption (percentage by weight)

Component A Radix Bupleuri 13

The Radix Astragali 7

Radix Saposhnikoviae 7

Radix Codonopsis 13

Herba Epimedii 13

Folium Isatidis 7

Caulis Lonicerae 20

Folium Acanthopanacis Senticosi 19

B component humic acids 1

Preparation method:

1. after the Chinese herbal medicine of respectively distinguishing the flavor of among the component A being mixed, behind water extract-alcohol precipitation, cross 100 mesh sieves;

2. B component is added among the A, mix until evenly;

When 3. using, mixed phase sneaked in the feedstuff according to 3% of forage compounding get final product.

Claims (1)

1, a kind of Chinese herb compound animal immunity potentiator is characterized in that this animal immunity potentiator is made up of the component of following percentage by weight:

The herbal component consumption

Radix Bupleuri 5～20

The Radix Astragali 5～20

Radix Saposhnikoviae 1～15

Radix Codonopsis 5～20

Herba Epimedii 1～15

Folium Isatidis 5～20

Caulis Lonicerae 5～30

Folium Acanthopanacis Senticosi 5～20

Humic acids 0.1～2.0