CN104886345A - Traditional Chinese medicine preparation for preventing weaned piglets from suffering diarrhea, and preparation method of traditional Chinese medicine preparation - Google Patents
Traditional Chinese medicine preparation for preventing weaned piglets from suffering diarrhea, and preparation method of traditional Chinese medicine preparation Download PDFInfo
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Abstract
The invention belongs to the technical field of traditional Chinese medicine preparations for beasts, and particularly relates to a traditional Chinese medicine preparation for preventing weaned piglets from suffering diarrhea, and a preparation method of the traditional Chinese medicine preparation. The traditional Chinese medicine preparation is mainly prepared from the following raw materials in parts by weight: plant extracts and glucose, wherein the plant extracts comprise dandelion extracts, astragalus membranaceus extracts, herba andrographitis extracts, and cordate houttuynia extracts. The preparation method of the medicine preparation comprises the following steps: sieving the plant extracts with a sieve of 50-70 meshes, uniformly mixing the sieved plant extracts, adding the glucose sieved by a sieve of 70-100 meshes in the mixed plant extracts, and uniformly mixing the sieved glucose with the mixed plant extracts so as to obtain the traditional Chinese medicine preparation. The traditional Chinese medicine preparation for preventing weaned piglets from suffering, disclosed by the invention, has significant effects of resisting bacteria and resisting viruses, and can significantly reinforce the immunity of weaned piglets; the traditional Chinese medicine preparation is rich in nutritional substances, so that the nutritional needs of weaned piglets can be met; the traditional Chinese medicine preparation has the advantages that the gastroenteric functions of weaned piglets can be regulated, the absorption of nutritional substances can be promoted, the daily gain of weaned piglets can be increased, and the feed converting rate can be increased, so that the phenomenon that the weaned piglets are liable to get diarrhea is effectively avoided.
Description
Technical field
The invention belongs to veterinary Chinese medicine formulation art, be specifically related to Chinese medicine preparation of a kind of preventing post-weaning diarrhea and preparation method thereof.
Background technology
At present, in the industry of raising pigs, in order to reproductive capacity, the minimizing epidemic disease improving sow is propagated to piglet by sow, promoting growing of piglet, the piglet in 3 ~ 5 week age is carried out wean, is one of effective measures of employing during domestic and international intensive pig production is produced.But, early weaning piglet is owing to being subject to autodigestion function imperfection, hypoimmunity, the stress such as physiology, nutrition and environment are subject to after adding wean, wean one week interior normal phenomenon that diarrhoea occurs, the lighter affects piglet normal growth and grows, severe one causes piglet dead, causes huge loss to Swine Production, also governs the universal of this advanced technology of early weaning piglet and application.
The phenomenon of the diarrhoea that piglet occurs after wean, malnutrition and growth retardation, solution main is at present in Weaned Growing Pig Diets, add antibiosis usually prevention of diarrhea in piglets, growth promoting effects.But Long-Time Service antibiotic easily produces drug tolerant bacteria and remain in swine product, and affects human health by food chain, threatens to human survival.
In recent years, studies have found that, some Chinese herb feed additives can promote growth of animals or poultry, suppress pathogen, and all right develop immunitypty, improves the premunition of livestock and poultry.Chen Guoshuns etc. have delivered " Chinese science and technology paper is online " paper that a section is entitled as " Effect disquisition of Chinese herbal feed additive preventing post-weaning diarrhea ", and the Chinese herbal feed additive of this paper is made up of the plant extracts of the bark of eucommia, the Radix Astragali, Radix Angelicae Sinensis and Poria cocos; Zhou Xueyu has delivered in " agricultural technology service " paper that a section is entitled as " research of Chinese traditional compound medicine control diarrhea of weaned piglets effect ", and this Chinese traditional compound medicine is that Radix Codonopsis, Poria cocos, the bighead atractylodes rhizome, Radix Glycyrrhizae and the Radix Astragali etc. add taste Sijunzi Tang; More than add Chinese herbal feed additive the experiment proved that, this Chinese herbal feed additive effectively can reduce the diarrhoea degree of weaned piglet, improve digestibility and the utilization rate of nutriment, strengthen metabolism, stimulate circulation, improve the speed of growth, but these Chinese herb feed additives have the bitter taste of traditional Chinese medicine, and palatability is poor, affect piglet feed intake, be unfavorable for the promotion and application of this Chinese herbal feed.
Chinese patent CN103549222B discloses composite feed additive of a kind of anti-grice diarrhoea and preparation method thereof, this composite feed additive is prepared from by Echinacea Purpurea Herb P.E, curcumin, Berberine hydrochloride, sodium butyrate, zinc methionine, dark plum, catechu, by improving animal immunizing power, reduce enteron aisle pH value, improve the Absorption of intestinal mucosa and suppress harmful microorganism to be bred, thus reach anti-diarrhea, growth promotion, raising feed efficiency and improve the aspect effects such as piglet fur sense organ.But curcumin is water insoluble in this additive, be difficult to after causing piglet to eat absorb, Berberine hydrochloride oral absorption is poor, cause this additive cannot play maximum drug effect, therefore, seeking green feed additive that is safe, efficient, nuisanceless, noresidue becomes the task of top priority.
Summary of the invention
In order to the Chinese herbal feed overcoming prior art prevention and therapy grice diarrhoea has not soluble in water, it is difficult to absorb, there is bitter taste, palatability is poor, affect the defect of piglet feed intake, the object of the present invention is to provide Chinese medicine preparation of a kind of preventing post-weaning diarrhea and preparation method thereof, to overcome the above problems.
The Chinese medicine preparation of a kind of preventing post-weaning diarrhea of the present invention, it comprises following component and parts by weight thereof:
Dandelion extract 10-25 part, Astragalus Root P.E 15-30 part, Andrographis Paniculata 8-22 part, houttuynia extract 10-20 part and glucose 5-15 part.
Further, the Chinese medicine preparation of preventing post-weaning diarrhea provided by the invention is preferably filled a prescription and is comprised following component and parts by weight thereof: dandelion extract 20 parts, Astragalus Root P.E 25 parts, Andrographis Paniculata 16 parts, houttuynia extract 18 parts of glucose 10 parts.
The Chinese medicine preparation of preventing post-weaning diarrhea provided by the invention also comprises following component and parts by weight thereof: Fructus Hordei Germinatus 8-16 part, rhizoma pinellinae praeparata 5-15 part, Semen Lablab Album 4-12 part, hawthorn 6-12 part and montmorillonite 8-18 part.
Further, the Chinese medicine preparation optimum formula of preventing post-weaning diarrhea provided by the invention comprises following component and parts by weight thereof: dandelion extract 20 parts, Astragalus Root P.E 25 parts, Andrographis Paniculata 16 parts, houttuynia extract 18 parts, glucose 10 parts, 12 parts, Fructus Hordei Germinatus, rhizoma pinellinae praeparata 10 parts, Semen Lablab Album 8 parts, hawthorn 10 parts and montmorillonite 12 parts.
The preparation method of wherein said dandelion extract is: add in extractor after being cleaned by dandelion raw material, adding 8-12 times amount volume fraction is the ethanol of 75-85%, and refluxing extraction 1-3 time, extracts 1-3h at every turn, filters, and merges extract; By extract decompression recycling ethanol, and to be concentrated into density be 1.20-1.25, obtains extract medicinal extract; The spray-dried machine of extract medicinal extract is dry, and the EAT of described spray dryer is 170-180 DEG C, and leaving air temp is 75-85 DEG C, and charging rate is 7-10ml/min, and feeding temperature is 40-50 DEG C, obtains dandelion extract.
Further, the preparation method of described Astragalus Root P.E is: add in extractor after being cleaned by Astragalus membranaceus raw material, add the water of 8-12 times amount, 1-2h is boiled in heating, adds the absolute ethyl alcohol of 5-7 times amount after cooling, stir and evenly mix, leave standstill 2-3h, filter, by decompression filtrate recycling ethanol, and to be concentrated into density be 1.20-1.25, obtain extract medicinal extract; The spray-dried machine of extract medicinal extract is dry, and the EAT of described spray dryer is 170-180 DEG C, and leaving air temp is 75-85 DEG C, and charging rate is 7-10ml/min, and feeding temperature is 40-50 DEG C, obtains Astragalus Root P.E.
Further, the preparation method of described Andrographis Paniculata is: add in extractor after being cleaned by Herba Andrographitis raw material, adding 8-12 times amount volume fraction is the ethanol of 75-85%, and refluxing extraction 1-3 time, extracts 1-3h at every turn, filters, and merges extract; By extract decompression recycling ethanol, and to be concentrated into density be 1.20-1.25, obtains extract medicinal extract; The spray-dried machine of extract medicinal extract is dry, and the EAT of described spray dryer is 170-180 DEG C, and leaving air temp is 75-85 DEG C, and charging rate is 7-10ml/min, and feeding temperature is 40-50 DEG C, obtains Andrographis Paniculata.
Further, the preparation method of described houttuynia extract is: add in extractor after being cleaned by cordate houttuynia raw material, add the water of 8-12 times amount, refluxing extraction 1-3 time, extract 1-3h at every turn, filter, merge extract; Extract being evaporated to density is 1.20-1.25, obtains extract medicinal extract; The spray-dried machine of extract medicinal extract is dry, and the EAT of described spray dryer is 170-180 DEG C, and leaving air temp is 75-85 DEG C, and charging rate is 7-10ml/min, and feeding temperature is 40-50 DEG C, obtains houttuynia extract.
In addition, present invention also offers a kind of preparation method of Chinese medicine preparation of preventing post-weaning diarrhea, comprise the following steps:
(1) by dandelion extract, Astragalus Root P.E, Andrographis Paniculata and houttuynia extract through 50-70 mesh sieve, for subsequent use;
(2) each plant extracts dry powder that step (1) is screened is added in mixer mix 25-35min, obtain plant extract mixtures;
(3) by the glucose that takes through 70-100 mesh sieve, for subsequent use;
(4) Fructus Hordei Germinatus, rhizoma pinellinae praeparata, Semen Lablab Album and hawthorn powder are broken into particle, soak 1-3h, add raw material 8-12 times amount soak by water 2-3 time, filter, merge decoction liquor; Decoction liquor being evaporated to density is 1.20-1.25, obtains mixed extract after spraying dry;
(5) montmorillonite is ground to form powdery, the glucose that the plant extract mixtures obtained with step (2), step (3) obtain and the mixed extract that step (4) obtains mix, and stir 35-45min, to obtain final product.
Wherein, the application of Chinese medicine preparation in the feed addictive preparing preventing post-weaning diarrhea of preventing post-weaning diarrhea of the present invention, the 0.2-0.4% of daily ration quality based on the addition of this Chinese medicine preparation, and Chinese medicine preparation of the present invention adds glucose, decreases the bitter taste of traditional Chinese medicine, increase the palatability of Chinese medicine preparation, this Chinese medicine preparation is easy to become solution in water simultaneously, also can direct administration soluble in water, adds the method for administration of piglet.
The main component of dandelion extract of the present invention is general flavone and Quercetin, this extract has clearing heat and detoxicating, the effect of anti-inflammation, to staphylococcus aureus, Pseudomonas aeruginosa and typhoid bacillus, there is significant effect, can effectively reduce bacterial relevant disease, strengthen the immunity of piglet.The main component of Astragalus Root P.E is Astragaloside IV and a small amount of astragalus polyose, this extract has the antibacterial action of develop immunitypty, antiviral, anti-oxidant and wide spectrum, to shigella dysenteriae, Diplococcus pneumopniae, gold-coloured staphylococci, Escherichia coli and salmonella, Gram-negative bacteria and gram-positive bacteria, all there is significant inhibitory action, to the gastroenteritis of weanling pig, bacterial diarrhoea, there is good preventive effect.The main component of Andrographis Paniculata is andrographolide and Dehydro and drographolide, has clearing heat and detoxicating, anti-infectious effect, and the main component of houttuynia extract is general flavone, has the effect for the treatment of bacillary dysentery.The immunity of piglet can be strengthened above after each plant extracts mixing, regulate the gastrointestinal function of piglet, promote the absorption of nutriment, thus occur diarrhoea and unfavorable condition of searching for food after weaned piglet can be prevented.
Wherein, Fructus Hordei Germinatus has treatment dyspepsia and does not disappear, abdominal fullness and distention, poor appetite, and vomit the effect of having loose bowels, Semen Lablab Album has antibacterial, antiviral effect, has detoxication to the vomiting, acute gastroenteritis etc. caused of poisoning by food.Hawthorn has the immunity strengthening body, antibacterial, the effect for the treatment of abdominal pain diarrhea.Montmorillonite has significant effect to treatment diarrhoea.Add the result for the treatment of that above Chinese medicine can strengthen the Chinese medicine preparation of preventing post-weaning diarrhea further, antibacterial, the antiviral effect of significant this Chinese medicine preparation of raising, improve the immunity of piglet, to the diarrhoea phenomenon occurred after weaned piglet, there is significant result for the treatment of.
In a word, the Chinese medicine preparation of preventing post-weaning diarrhea provided by the invention, compared with prior art has following advantage:
1) Chinese medicine preparation of preventing post-weaning diarrhea provided by the invention has antibacterial, antiviral effect significantly, can improve the immunity of piglet significantly, occurs the phenomenon of suffering from diarrhoea after can effectively preventing weaned piglet;
2) Chinese medicine preparation of preventing post-weaning diarrhea provided by the invention has abundant nutriment, can meet the nutritional need of piglet, improve function of intestinal canal, improves weanling pig daily gain and feed efficiency, efficiently solves a difficult problem for diarrhea of weaned piglets;
3) Chinese medicine preparation of preventing post-weaning diarrhea provided by the invention decreases the bitter taste of Chinese traditional herbs additive, good palatability, during as feed addictive, improves weanling pig daily gain and feed efficiency; The all right direct administration soluble in water of this Chinese medicine preparation, is conducive to absorbing of Chinese medicine preparation, adds the method for administration of this Chinese medicine preparation;
4) Chinese medicine preparation of preventing post-weaning diarrhea provided by the invention is pure Chinese medicinal preparation, and avoiding the drug resistance and problem of environmental pollution that use antibiotic and chemical synthetic drug to produce, is a kind of green, the Chinese medicine preparation of environmental protection.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.
embodiment 1,the preparation of dandelion extract
The preparation method of dandelion extract, comprises the following steps:
Add in extractor after being cleaned by dandelion raw material, adding 10 times amount volume fractions is the ethanol of 85%, and refluxing extraction 2 times, extracts 2h at every turn, filters, and merges extract; By extract decompression recycling ethanol, and to be concentrated into density be 1.20-1.25, obtains extract medicinal extract; The spray-dried machine of extract medicinal extract is dry, and the EAT of described spray dryer is 170 DEG C, and leaving air temp is 75 DEG C, and charging rate is 8ml/min, and feeding temperature is 45 DEG C; Obtain dandelion extract.
embodiment 2,the preparation of Astragalus Root P.E
The preparation method of Astragalus Root P.E, comprises the following steps:
Add in extractor after being cleaned by Astragalus membranaceus raw material, add the water of 10 times amount, 1h is boiled in heating, adds the absolute ethyl alcohol of 6 times amount, stir and evenly mix after cooling, leaves standstill 2h, filters, and by decompression filtrate recycling ethanol, and to be concentrated into density be 1.20-1.25, obtains extract medicinal extract; The spray-dried machine of extract medicinal extract is dry, and the EAT of described spray dryer is 170 DEG C, and leaving air temp is 75 DEG C, and charging rate is 8ml/min, and feeding temperature is 45 DEG C; Obtain Astragalus Root P.E.
embodiment 3,the preparation of Andrographis Paniculata
The preparation method of Andrographis Paniculata, comprises the following steps:
Add in extractor after being cleaned by Herba Andrographitis raw material, adding 10 times amount volume fractions is the ethanol of 85%, and refluxing extraction 2 times, extracts 2h at every turn, filters, and merges extract; By extract decompression recycling ethanol, and to be concentrated into density be 1.20-1.25, obtains extract medicinal extract; The spray-dried machine of extract medicinal extract is dry, and the EAT of described spray dryer is 170 DEG C, and leaving air temp is 75 DEG C, and charging rate is 8ml/min, and feeding temperature is 45 DEG C; Obtain Andrographis Paniculata.
embodiment 4,the preparation of houttuynia extract
The preparation method of houttuynia extract, comprises the following steps:
Add in extractor after being cleaned by cordate houttuynia raw material, add the water of 10 times amount, refluxing extraction 2 times, extracts 2h at every turn, filters, and merges extract; Extract being evaporated to density is 1.20-1.25, obtains extract medicinal extract; The spray-dried machine of extract medicinal extract is dry, and the EAT of described spray dryer is 170 DEG C, and leaving air temp is 75 DEG C, and charging rate is 8ml/min, and feeding temperature is 45 DEG C; Obtain houttuynia extract.
embodiment 5,the Chinese medicine preparation of preventing post-weaning diarrhea
The Chinese medicine preparation of preventing post-weaning diarrhea comprises following component and parts by weight thereof:
Dandelion extract 100g, Astragalus Root P.E 150g, Andrographis Paniculata 80g, houttuynia extract 100g and glucose 50g.
The preparation method of the Chinese medicine preparation of preventing post-weaning diarrhea, comprises the following steps:
(1) by each plant extracts dry powder through 50 mesh sieves, for subsequent use;
(2) each plant extracts dry powder that step (1) is screened is added in mixer mix 25min, obtain plant extract mixtures;
(3) by the glucose that takes through 70 mesh sieves, for subsequent use;
(4) added in the mixture of step (2) by the glucose that step (3) obtains and mix, mixing 35min, to obtain final product.
embodiment 6,the Chinese medicine preparation of preventing post-weaning diarrhea
The Chinese medicine preparation of preventing post-weaning diarrhea comprises following component and parts by weight thereof:
Dandelion extract 200g, Astragalus Root P.E 250g, Andrographis Paniculata 160g, houttuynia extract 180g and glucose 100g.
The preparation method of the Chinese medicine preparation of preventing post-weaning diarrhea, comprises the following steps:
(1) by each plant extracts dry powder through 60 mesh sieves, for subsequent use;
(2) each plant extracts dry powder that step (1) is screened is added in mixer mix 30min, obtain plant extract mixtures;
(3) by the glucose that takes through 80 mesh sieves, for subsequent use;
(4) added in the mixture of step (2) by the glucose that step (3) obtains and mix, mixing 30min, to obtain final product.
embodiment 7,the Chinese medicine preparation of preventing post-weaning diarrhea
The Chinese medicine preparation of anti-diarrhea of weaned piglets comprises following component and parts by weight thereof:
Dandelion extract 250g, Astragalus Root P.E 300g, Andrographis Paniculata 220g, houttuynia extract 200g and glucose 150g.
The Chinese medicine preparation preparation method of anti-diarrhea of weaned piglets, comprises the following steps:
(1) by each plant extracts dry powder through 70 mesh sieves, for subsequent use;
(2) each plant extracts dry powder that step (1) is screened is added in mixer mix 35min, obtain plant extract mixtures;
(3) by the glucose that takes through 100 mesh sieves, for subsequent use;
(4) added in the mixture of step (2) by the glucose that step (3) obtains and mix, mixing 45min, to obtain final product.
embodiment 8,the Chinese medicine preparation of preventing post-weaning diarrhea
The Chinese medicine preparation of anti-diarrhea of weaned piglets comprises following component and parts by weight thereof:
Dandelion extract 200g, Astragalus Root P.E 250g, Andrographis Paniculata 160g, houttuynia extract 180g, glucose 100g, Fructus Hordei Germinatus 120g, rhizoma pinellinae praeparata 100g, Semen Lablab Album 80g, hawthorn 100g and montmorillonite 120g.
The Chinese medicine preparation preparation method of anti-diarrhea of weaned piglets, comprises the following steps:
(1) by each plant extracts dry powder through 60 mesh sieves, for subsequent use;
(2) each plant extracts dry powder that step (1) is screened is added in mixer mix 25-35min, obtain plant extract mixtures;
(3) by the glucose that takes through 80 mesh sieves, for subsequent use;
(4) Fructus Hordei Germinatus, rhizoma pinellinae praeparata, Semen Lablab Album and hawthorn powder are broken into particle, soak 2h, add raw material 10 times amount soak by water 2 times, filter, merge decoction liquor; Decoction liquor being evaporated to density is 1.20-1.25, obtains mixed extract after spraying dry.
(5) montmorillonite is ground to form powdery, the glucose that the plant extract mixtures obtained with step (2), step (3) obtain and the mixed extract that step (4) obtains mix, and stir 40min, to obtain final product.
embodiment 9,the Chinese medicine preparation of preventing post-weaning diarrhea
The Chinese medicine preparation of anti-diarrhea of weaned piglets comprises following component and parts by weight thereof:
Dandelion extract 200g, Astragalus Root P.E 250g, Andrographis Paniculata 160g, houttuynia extract 180g, glucose 100g, Fructus Hordei Germinatus 80g, rhizoma pinellinae praeparata 120g, Semen Lablab Album 40g, hawthorn 120g and montmorillonite 80g.
Preparation method is as embodiment 8.
comparative example 1,a kind of Chinese medicine preparation of preventing post-weaning diarrhea
The Chinese medicine preparation of preventing post-weaning diarrhea comprises following component and parts by weight thereof:
Dandelion extract 250g, Astragalus Root P.E 280g, houttuynia extract 200g and glucose 150g;
Preparation method is as embodiment 6.
comparative example 2,a kind of Chinese medicine preparation of preventing post-weaning diarrhea
The Chinese medicine preparation of preventing post-weaning diarrhea comprises following component and parts by weight thereof:
Fructus Hordei Germinatus 120g, rhizoma pinellinae praeparata 100g, Semen Lablab Album 80g, hawthorn 100g and montmorillonite 120g;
Its preparation method comprises the following steps: Fructus Hordei Germinatus, rhizoma pinellinae praeparata, Semen Lablab Album and hawthorn powder are broken into particle, soak 2h, adds raw material 10 times amount soak by water 2 times, filters, and merges decoction liquor; Decoction liquor being evaporated to density is 1.20-1.25, obtains mixed extract after spraying dry; Montmorillonite is ground to form powdery mix with mixed extract, stir 40min, to obtain final product.
test example one,the Chinese medicine preparation of preventing post-weaning diarrhea is on the impact of weaned piglets
1, subjects: choose the wean that age in days is 28 ± 1, the healthy weanling pig of average weight 6.0-6.3kg 55, is divided into 5 groups at random, be respectively control group, feed 1 group, feed 2 groups, feed 3 groups, feed 4 groups, often organize 11.
2, test method:
Basal diet is based on corn-soybean meal, and the feed of each group is as follows:
Control group: basal diet of feeding;
Feed 1 group: mixed fodder of feeding, described mixed fodder is the Chinese medicine preparation adding 0.3% embodiment 6 preparation in basal diet;
Feed 2 groups: mixed fodder of feeding, described mixed fodder is the Chinese medicine preparation adding 0.3% embodiment 8 preparation in basal diet;
Feed 3 groups: mixed fodder of feeding, described mixed fodder is the Chinese medicine preparation adding 0.3% comparative example 1 preparation in basal diet;
Feed 4 groups: mixed fodder of feeding, described mixed fodder is the Chinese medicine preparation adding 0.3% comparative example 2 preparation in basal diet;
Each group of piglet adopts high bed crack to raise, and conveniently carries out disinfection to pig house, makes its free choice feeding, drinking-water.After feeding 2 weeks, carry out empty stomach weigh to piglet, calculate weightening finish and feed-weight ratio, feed-weight ratio is the ratio of feeding feed stuff gross weight and weight gain of piglets.
3, test index detects
Often organize the diarrhea rate of piglet in record experimental period every day, and in the 14th day morning of experimental period, empty stomach is only carried out to piglet and weigh, calculate pig and increase weight and feed-weight ratio.
4, result of the test
Result of the test is as shown in table 1.
The Chinese medicine preparation of table 1 preventing post-weaning diarrhea is on the impact of weaned piglets
| Control group | Feed 1 group | Feed 2 groups | Feed 3 groups | Feed 4 groups | |
| Starting weight (kg) | 6.00±0.84 | 6.10±0.80 | 6.04±1.30 | 6.08±1.30 | 6.04±0.72 |
| End heavy (kg) | 8.54±0.87 | 9.96±0.64 | 10.02±1.02 | 9.34±1.10 | 9.42±0.84 |
| Daily ingestion amount (g/d) | 192.28±37.22 A | 300.42±30.52 B | 340.84±36.20 B | 259.84±41.41 AB | 268.2±40.88 AB |
| Day increment (g/d) | 184.80±41.68 A | 288.68±28.52 B | 308.56±36.24 B | 226.56±38.43 AB | 236.88±36.34 AB |
| Feed-weight ratio | 1.10±0.08 | 1.20±0.02 | 1.26±0.02 | 1.11±0.01 | 1.12±0.04 |
| Diarrhea rate (%) | 4.98±1.84 a | 1.42±0.76 b | 1.22±0.56 b | 2.97±0.67 ab | 2.82±0.70 ab |
Note: colleague's data shoulder mark capitalization difference represents that difference extremely significantly (P<0.01), and lowercase difference represents significant difference (P<0.05), and identical table differential is different not significantly (P>0.05).
Can be drawn by table 1, be added with feed 1 group of the Chinese medicine preparation of preventing post-weaning diarrhea, feed 2 groups, feed 3 groups and feed 4 groups, daily ingestion amount after wean in 2 weeks, day increment and diarrhoea control rate are all better than control group, wherein, and feed 1 group and the daily ingestion amount of 2 groups of feeding, daily gain and diarrhoea control rate are better than feeding 3 groups and feed 4 groups, and be significantly better than control group, show that the Chinese medicine preparation of preventing post-weaning diarrhea provided by the invention significantly can improve intestinal growth and the health of weanling pig, the stress reaction of weaned piglet can be alleviated, feed intake and the scale of construction after effective raising weaned piglet, effectively solve the diarrhoea problem of weanling pig, the Chinese medicine preparation most pronounced effects of preventing post-weaning diarrhea prepared by 2 groups of embodiments of feeding 8 of wherein feeding.
test example two,the Chinese medicine preparation of preventing post-weaning diarrhea is on the impact of piglet nutrient digestibility
1, subjects: choose the wean that age in days is 28 ± 1, the healthy weanling pig of average weight 6.0-6.3kg 55, is divided into 5 groups at random, be respectively control group, feed 1 group, feed 2 groups, feed 3 groups, feed 4 groups, often organize 11.
2, test method:
Basal diet is based on corn-soybean meal, and the feed of each group is as follows:
Control group: basal diet of feeding;
Feed 1 group: mixed fodder of feeding, described mixed fodder is the Chinese medicine preparation adding 0.3% embodiment 6 preparation in basal diet;
Feed 2 groups: mixed fodder of feeding, described mixed fodder is the Chinese medicine preparation adding 0.3% embodiment 8 preparation in basal diet;
Feed 3 groups: mixed fodder of feeding, described mixed fodder is the Chinese medicine preparation adding 0.3% comparative example 1 preparation in basal diet;
Feed 4 groups: mixed fodder of feeding, described mixed fodder is the Chinese medicine preparation adding 0.3% comparative example 2 preparation in basal diet;
Each group of piglet adopts high bed crack to raise, and conveniently carries out disinfection to pig house, makes its free choice feeding, drinking-water.Raise 4 weeks, during carrying out feeding experiment, within last 1 week, adopt endogenous indicator method to carry out digestion trial in test, experimental period is 7d, and wherein preliminary trial period is 3d, observes feed intake and the defecation rule of pig; Just the phase of trying is 4d, receives excrement every day 3 times, each about 100g, loads sealing plastic bag sealing, preserves in-30 DEG C of refrigerators.
3, result of the test
Result of the test is as shown in table 2.
The digestibility test data of table 2 weanling pig
| Crude protein | Calcium | Phosphorus | Dry | |
| Control group | 83.82±0.04a | 46.68±0.10a | 68.80±0.06a | 78.28±0.34a |
| Feed 1 group | 89.88±0.04b | 54.98±0.04b | 74.08±0.05b | 87.04±0.06b |
| Feed 2 groups | 91.76±0.03b | 60.34±0.04b | 76.12±0.04b | 89.00±0.02b |
| Feed 3 groups | 85.52±0.06ab | 49.78±0.08ab | 71.14±0.08ab | 81.24±0.02ab |
| Feed 4 groups | 86.22±0.04ab | 48.88±0.06ab | 72.28±0.06ab | 82.08±0.04ab |
Note: take on marking-up parent phase in same row and represent difference not significantly (P>0.05) with person, shoulder mark adjacent letters person represents significant difference (P<0.05), and the non-adjacent alphabetical person of shoulder mark represents that difference extremely significantly (P<0.01).
Known by table 2, be added with feed 1 group of the Chinese medicine preparation of preventing post-weaning diarrhea, feed 2 groups, feed 3 groups and feed 4 groups, crude protein in 4 weeks after wean, calcium, the digestibility of phosphorus and dry is obviously better than control group, wherein to feed 1 group and the crude protein of 2 groups of feeding, calcium, the digestibility of phosphorus and dry is better than feeding 3 groups and feed 4 groups, and be significantly better than control group, prove that the Chinese medicine preparation of preventing post-weaning diarrhea of the present invention significantly can improve piglet to protein, calcium, the digestibility of phosphorus and dry, can efficient solution to determine the diarrhoea problem of weanling pig, the Chinese medicine preparation most pronounced effects of preventing post-weaning diarrhea prepared by 2 groups of embodiments of feeding 8 of wherein feeding.
Claims (10)
1. a Chinese medicine preparation for preventing post-weaning diarrhea, is characterized in that, comprises following component and parts by weight thereof:
Dandelion extract 10-25 part, Astragalus Root P.E 15-30 part, Andrographis Paniculata 8-22 part, houttuynia extract 10-20 part and glucose 5-15 part.
2. the Chinese medicine preparation of preventing post-weaning diarrhea as claimed in claim 1, is characterized in that, comprise following component and parts by weight thereof:
Dandelion extract 20 parts, Astragalus Root P.E 25 parts, Andrographis Paniculata 16 parts, houttuynia extract 18 parts and glucose 10 parts.
3. the Chinese medicine preparation of preventing post-weaning diarrhea as claimed in claim 1, is characterized in that, also comprise following component and parts by weight thereof:
Fructus Hordei Germinatus 8-16 part, rhizoma pinellinae praeparata 5-15 part, Semen Lablab Album 4-12 part, hawthorn 6-12 part and montmorillonite 8-18 part.
4. the Chinese medicine preparation of the preventing post-weaning diarrhea as described in as arbitrary in claim 1-3, is characterized in that, comprise following component and parts by weight thereof:
Dandelion extract 20 parts, Astragalus Root P.E 25 parts, Andrographis Paniculata 16 parts, houttuynia extract 18 parts, glucose 10 parts, 12 parts, Fructus Hordei Germinatus, rhizoma pinellinae praeparata 10 parts, Semen Lablab Album 8 parts, hawthorn 10 parts and montmorillonite 12 parts.
5. the Chinese medicine preparation of preventing post-weaning diarrhea as claimed in claim 1, it is characterized in that, the preparation method of described dandelion extract is:
Add in extractor after being cleaned by dandelion raw material, adding 8-12 times amount volume fraction is the ethanol of 75-85%, and refluxing extraction 1-3 time, extracts 1-3h at every turn, filters, and merges extract; By extract decompression recycling ethanol, and to be concentrated into density be 1.20-1.25, obtains extract medicinal extract; The spray-dried machine of extract medicinal extract is dry, and the EAT of described spray dryer is 170-180 DEG C, and leaving air temp is 75-85 DEG C, and charging rate is 7-10ml/min, and feeding temperature is 40-50 DEG C, obtains dandelion extract.
6. the Chinese medicine preparation of preventing post-weaning diarrhea as claimed in claim 1, it is characterized in that, the preparation method of described Astragalus Root P.E is:
Add in extractor after being cleaned by Astragalus membranaceus raw material, add the water of 8-12 times amount, 1-2h is boiled in heating, adds the absolute ethyl alcohol of 5-7 times amount after cooling, stir and evenly mix, leave standstill 2-3h, filter, by decompression filtrate recycling ethanol, and to be concentrated into density be 1.20-1.25, obtains extract medicinal extract; The spray-dried machine of extract medicinal extract is dry, and the EAT of described spray dryer is 170-180 DEG C, and leaving air temp is 75-85 DEG C, and charging rate is 7-10ml/min, and feeding temperature is 40-50 DEG C, obtains Astragalus Root P.E.
7. the Chinese medicine preparation of preventing post-weaning diarrhea as claimed in claim 1, it is characterized in that, the preparation method of described Andrographis Paniculata is:
Add in extractor after being cleaned by Herba Andrographitis raw material, adding 8-12 times amount volume fraction is the ethanol of 75-85%, and refluxing extraction 1-3 time, extracts 1-3h at every turn, filters, and merges extract; By extract decompression recycling ethanol, and to be concentrated into density be 1.20-1.25, obtains extract medicinal extract; The spray-dried machine of extract medicinal extract is dry, and the EAT of described spray dryer is 170-180 DEG C, and leaving air temp is 75-85 DEG C, and charging rate is 7-10ml/min, and feeding temperature is 40-50 DEG C, obtains Andrographis Paniculata.
8. the Chinese medicine preparation of preventing post-weaning diarrhea as claimed in claim 1, it is characterized in that, the preparation method of described houttuynia extract is:
Add in extractor after cordate houttuynia raw material is cleaned, add the water of 8-12 times amount, refluxing extraction 1-3 time, extract 1-3h at every turn, filter, merge extract; Extract being evaporated to density is 1.20-1.25, obtains extract medicinal extract; The spray-dried machine of extract medicinal extract is dry, and the EAT of described spray dryer is 170-180 DEG C, and leaving air temp is 75-85 DEG C, and charging rate is 7-10ml/min, and feeding temperature is 40-50 DEG C, obtains houttuynia extract.
9. a preparation method for the Chinese medicine preparation of the preventing post-weaning diarrhea as described in as arbitrary in claim 1-8, is characterized in that, comprise the following steps:
(1) by dandelion extract, Astragalus Root P.E, Andrographis Paniculata and houttuynia extract through 50-70 mesh sieve, for subsequent use;
(2) each plant extracts dry powder that step (1) is screened is added in mixer mix 25-35min, obtain plant extract mixtures;
(3) by the glucose that takes through 70-100 mesh sieve, for subsequent use;
(4) Fructus Hordei Germinatus, rhizoma pinellinae praeparata, Semen Lablab Album and hawthorn powder are broken into particle, soak 1-3h, add raw material 8-12 times amount soak by water 2-3 time, filter, merge decoction liquor; Decoction liquor being evaporated to density is 1.20-1.25, obtains mixed extract after spraying dry;
(5) montmorillonite is ground to form powdery, the glucose that the plant extract mixtures obtained with step (2), step (3) obtain and the mixed extract that step (4) obtains mix, and stir 35-45min, to obtain final product.
10. the application of Chinese medicine preparation in the feed addictive preparing preventing post-weaning diarrhea of the preventing post-weaning diarrhea as described in as arbitrary in claim 1-9.
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| CN105394385A (en) * | 2015-11-16 | 2016-03-16 | 广州暨南生物医药研究开发基地有限公司 | Traditional Chinese medicine preparation for preventing stress syndromes of weanling pigs and preparation method of traditional Chinese medicine preparation |
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| CN106472837A (en) * | 2016-09-30 | 2017-03-08 | 安徽华澳生物技术有限公司 | A kind of feed additive of preventing and treating diarrhea of weaned piglets |
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| CN107691848A (en) * | 2017-11-08 | 2018-02-16 | 独山县肖氏畜牧业发展有限公司 | A kind of feed for raising porkling and preparation method thereof |
| CN107714838A (en) * | 2017-11-21 | 2018-02-23 | 江苏农牧科技职业学院 | A kind of Chinese medicine composition for preventing and treating diarrhea of weaned piglets and its application |
| CN110742943A (en) * | 2019-11-14 | 2020-02-04 | 吉林大学 | Fermented Chinese herbal medicine preparation and preparation method and application thereof |
| CN111759988A (en) * | 2020-07-16 | 2020-10-13 | 山西农业大学 | Traditional Chinese medicine preparation for improving immunity of weaned piglets and preparation method |
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Address after: 528437 Torch Development Zone, Guangdong, Zhongshan Province, No. 8, Eurasia Road, National Health Science and Technology Industrial Base Patentee after: Guangdong tengjun Pharmaceutical Co., Ltd Address before: 528437 Torch Development Zone, Guangdong, Zhongshan Province, No. 8, Eurasia Road, National Health Science and Technology Industrial Base Patentee before: GUANGDONG GALLOPER VETERINARY PHARMACEUTICAL Co.,Ltd. |
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