CN107714838A - A kind of Chinese medicine composition for preventing and treating diarrhea of weaned piglets and its application - Google Patents
A kind of Chinese medicine composition for preventing and treating diarrhea of weaned piglets and its application Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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Abstract
The invention discloses a kind of Chinese medicine composition for preventing and treating diarrhea of weaned piglets and its application, it is made up of following raw material according to weight：20 30 parts of the Chinese bulbul, 10 25 parts of fortune paulownia flower, 15 25 parts of jatamans valeriana rhizome.The present invention uses above-mentioned Chinese medicine material compatibility, manufacture craft is simple and easy, and drug effect collaboration promotes, and treatment grice diarrhoea cure rate is high, it is curative for effect, it is quick, medicament residue is not produced compared with chemical drug for animals, without any toxicity and side effects, abundant raw material, it is cheap, beneficial to popularization, there is good application prospect.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and its application for being used to prevent and treat diarrhea of weaned piglets, belong to middle beast
The technical field of medicine.
Background technology
Grice diarrhoea is a kind of typical multifactor property disease under intensive pig production working condition, and the disease is most tight at present
One of piglet diseases group of weight, and cause the dead major reason of piglet.The physiological defect of weanling pig itself, digestive organs
Imperfection is developed, intestinal villi and lymphocyte etc. are in growth and development stage, and intestinal villi is highly susceptible to Bacteria destroyed, subtracts
Effective absorbing area of the small intestine to nutrient is lacked, the nutriment in chyme can not be digested and assimilated well, can only be with abdomen
The form discharge rushed down；Early-weaned pigletses immunity is weaker, hydrochloric acid in gastric juice deficiency, the digested enzyme activity of piglet digestive in piglet digestive
Property the invasion and attack of relatively low, pathogenic microorganism（Virus, bacterium, protozoon, worm）, severe external environmental condition induces（Temperature, humidity,
Air）And cause the main inducing of grice diarrhoea.
Counted according to FAO (Food and Agriculture Organization of the United Nation), China livestock on hand sow 37,980,000 in 2015, produce piglet 7.08 hundred million per year, deliver for sale
5.9 hundred million, with the development of pig industry in recent years, amount of livestock on hand increase, loss caused by piglet is dead further aggravates, with cultivation
The horizontal main gap of developed country's cultivation is that the piglet death rate is higher, wherein diarrhoea is to cause main causes of death.According to
Report, below 30kg piglet, the average of the whole year incidence of disease 46.5%, the death rate 10.3%, grice diarrhoea occupy in pig industry harm
First place, the piglet death rate in China are generally 15% -20%, and Suprapubic arch sling average 11% -25%, the piglet more than 80% that dies of illness is dysentery
Disease is dead, and larger economic loss is caused to pig industry.
At present, on husbandry sector, preventing and treating suckling pig diarrhoea is mainly by using antibiotics, improvement raising ring
The measures such as border condition realize, piglet be mainly administered using intramuscular injection mode and increases piglet stress, and easy generation medicine is residual
Stay problem.And when taking remedy measures unreasonable, tend to cause piglet dead, bring tremendous economic to damage to breeding enterprise
Lose.
The content of the invention
In view of this, the defects of existing for existing prevention and treatment grice diarrhoea medicine and method, the present invention provides
It is a kind of using pure Chinese medicine raw material, cure rate is high, cost is low, do not produce medicament residue preventing and treating piglet diarrhoea Chinese medicine composition
Preparation and its application, it is for preventing and treating by staphylococcus aureus, pseudomonas aeruginosa, shigella dysenteriae, pig typhoid fever sramana
Salmonella, Salmonella choleraesuls, Escherichia coli O2、O78、O149、O101Caused bacterial diarrhea and chronic enteritis, adaptive colitis
There is significant curative effect etc. chronic diarrhea.
In order to solve the above technical problems, the present invention provides following technical scheme：
A kind of Chinese medicine composition for being used to prevent and treat piglet diarrhoea, is prepared by following raw material in parts by weight：In vain
Head father-in-law 20-30 parts, fortune paulownia flower 10-25 parts, jatamans valeriana rhizome 15-25 parts.
Preferably, the Chinese medicine composition of the prevention and treatment diarrhea of weaned piglets, by weight by following components group
Into：25 parts of the Chinese bulbul, 11 parts of fortune paulownia flower, 20 parts of jatamans valeriana rhizome.
Preferably, the Chinese medicine composition of the prevention and treatment diarrhea of weaned piglets, by weight by following components group
Into：28 parts of the Chinese bulbul, 17 parts of fortune paulownia flower, 18 parts of jatamans valeriana rhizome.
Most preferably, the Chinese medicine composition of the prevention and treatment diarrhea of weaned piglets, by weight by following components
Composition：30 parts of the Chinese bulbul, 20 parts of fortune paulownia flower, 15 parts of jatamans valeriana rhizome.
The application of the Chinese medicine composition of prevention and treatment weanling pig bacterial diarrhea proposed by the present invention, said composition master
Be used for prevent and treat mainly by staphylococcus aureus, pseudomonas aeruginosa, shigella dysenteriae, moscow' typhisuis, pig suddenly
Random salmonella, Escherichia coli O2、O78、O149、O101Caused diarrhea of weaned piglets.
The Chinese medicine composition of prevention and treatment weanling pig bacterial diarrhea proposed by the invention has below beneficial to effect
Fruit：
（1）Pharmacodynamic experiment shows, the Chinese medicine composition of prevention and treatment weanling pig bacterial diarrhea proposed by the invention
Have what is preferably treated and prevented to C57BL/6 mouse caused by different serotypes Escherichia coli and weanling pig bacterial diarrhea
Effect, in the effect for the treatment of and prevention artificial challenge mouse, diarrhea of weaned piglets tests, weanling pig can be significantly decreased
With the death rate of artificial challenge mouse, effectively reduce or contain diarrhoea number, and increase it with drug concentration within the specific limits
Curative effect gradually strengthens, and cure rate is up to 60%~80%.
（2）There is the Chinese medicine composition of prevention and treatment weanling pig bacterial diarrhea proposed by the invention righting to dispel
Evil, regulating qi-flowing for relieving pain, help digestion antidiarrheal, the effect of dispelling wind and eliminating dampness, relieving diarrhea with astringents, to staphylococcus aureus, pseudomonas aeruginosa, will
Congratulating the bacterial diarrheas such as bacterium, moscow' typhisuis, Salmonella choleraesuls, Escherichia coli has obvious therapeutic action, is facing
Adverse reaction is had no during bed observation, for the ideal medicine for the treatment of weanling pig bacterial diarrhea.
Embodiment
Following examples are not construed as limiting the invention to further illustrate the present invention.
Product prepares embodiment：
Embodiment 1
The Chinese medicine composition of prevention and treatment piglet bacillary diarrhoea proposed by the invention, include the group of following ratio of weight and number
Part：
25 parts of the Chinese bulbul, 11 parts of fortune paulownia flower, 20 parts of jatamans valeriana rhizome.
The preparation method of the Chinese medicine composition of prevention and treatment piglet bacillary diarrhoea proposed by the invention includes following
Step：
（1）Above-mentioned each component 30min is soaked with the pure water of 8 times of weight；
（2）By step（1）Chinese medicine composition intense fire be heated to seething with excitement, turn slow fire keep 30min；
（3）With filtered through gauze retain filtrate, then add 8 times of weight water into the dregs of a decoction, intense fire is heated to seething with excitement, turn slow fire holding
30min, filter again, merge filtrate twice
（4）By step（3）The filtrate concentration of gained is made original pharmaceutical content and produced for 1g/ml
Embodiment 2
The Chinese medicine composition of prevention and treatment piglet bacillary diarrhoea proposed by the invention, include the group of following ratio of weight and number
Part：
30 parts of the Chinese bulbul, 20 parts of fortune paulownia flower, 15 parts of jatamans valeriana rhizome.
The preparation method of the Chinese medicine composition of prevention and treatment piglet bacillary diarrhoea proposed by the invention includes following
Step：According to raw material needed for the Chinese medicine composition preparation of above-mentioned preventing and treating grice diarrhoea, each bulk drug is by cleaning, washing, doing
It is dry, respectively crush, cross 100 mesh sieves, then mixed according to the parts by weight of the Chinese medicine composition of above-mentioned preventing and treating grice diarrhoea
Close, dispense and produce after mixing.
The Chinese medicine composition of the present invention of embodiment 3 is to artificial challenge Escherichia coli O101Strain causes the therapeutic action of diarrhea of mouse
1. test material
1.1 medicine：The Chinese medicine composition of the embodiment of the present invention 1；Positive control drug is gentamicin sulphate；Negative control medicine is
Physiological saline.
1.2 test strain：Escherichia coli O101Strain, by the laboratory separation of animal drugs institute of Jiangsu Agri-Animal Husbandry Vocational College
Preserve.
The g of 1.3 experimental animal SPF level C57BL/6 mouse 18~22, purchased from Yangzhou University's veterinary college comparative medicine
The heart.Animal productiong licensing number：SCXK（Soviet Union）2012-004, use credit number：SCXK（Soviet Union）2012-0004.Feeding environment
Cleaning is kept, environment temperature is 24-26 DEG C, humidity 60%-70%.
2. test method
The processing of 2.1 experimental animals
18~22 g of SPF level C57BL/6 mouse totally 60, is randomly divided into 6 groups, respectively tests high dose group, tests middle dosage
Group, experiment low dose group, positive controls, negative control group, Normal group, every group 10, male and female half and half.Except normal control
Other outer animals of group are with Escherichia coli O101The ordinary broth culture of strain carries out that 0.4 mL is injected intraperitoneally（Bacteria containing amount is about 2.4 ×
108cfu）, about 2~4 h mouse are suffered from diarrhoea after injection, and each group gavage gives corresponding tested material.Obtained in embodiment 1
Chinese medicine composition high dose group 1mg/ml, middle dose group 0.5mg/ml, low dose group 0.25mg/ml, positive controls are
Gentamicin sulphate 1ml/kg, negative control group physiological saline 0.2ml/10g body weight, Normal group are not dealt with, and raise ring
Border is identical.1 time a day, it is used in conjunction 5 days.
2.2 observation index
Observation and record each group animal incidence and clinical manifestation.Excrement situation, diarrhoea number are recorded, calculates the death of each group
Rate, cure rate and Gain weight.Cut open inspection dead animal, take pathological material of disease to carry out Isolation and culture of agent and identification, analysed after off-test
Observation, and record its lesion situation.Acquired results with test group compared with positive controls, administration group and Normal group ratio
Compared with.
3. result of the test
Result of the test shows, it is more equal with negative control group that mouse death rate, cure rate and the pathology of each medication group analyse change
There were significant differences, illustrates that Chinese medicine composition of the present invention can significantly reduce the death rate of artificial challenge's mouse colibacillosis.Senior middle school
Dosage group cure rate is up to 80%, and more slightly higher than positive drug control group, low dose group cure rate is up to 70%, with positive drug control group
It is identical.And therapeutic effect shows the trend of dose dependent increase to a certain extent.There is clinical condition after 2~4 h of infection
Shape, 24h start animal dead occur, and mouse is mainly shown as that spirit is tired, and body is rolled up, and hair is in disorder and with diseases such as diarrhoea
Shape.Drug-treated group upon administration 4~6 h can be observed suffer from diarrhoea number have obvious reduction, concrete outcome is shown in Table 1~2.
Therapeutic effect of the various dose group of table 1. to mouse
Influence after the administration of the various dose group of table 2. to diarrhea of mouse average time
4 Chinese medicine composition of the present invention of embodiment is to artificial challenge Escherichia coli O101Strain causes the prevention effect of diarrhea of mouse
1. test material
The Chinese medicine composition of the 1.1 medicine embodiment of the present invention 1；Positive control drug gentamicin sulphate；Negative control medicine is made a living
Manage salt solution
1.2 test strain：Escherichia coli O101, preserved by the laboratory separation of animal drugs institute of Jiangsu Agri-Animal Husbandry Vocational College
The g of 1.3 experimental animal SPF level C57BL/6 mouse 18~22, purchased from Yangzhou University's comparative medicine center, animal productiong is permitted
Can the number of card：SCXK（Soviet Union）2012-004, use credit number：SCXK（Soviet Union）2012-0004.Feeding environment keeps cleaning, environment
Temperature is 24-26 DEG C, humidity 60%-70%.
2. test method
The processing of 2.1 experimental animals
By 60 SPF level C57BL/6 mouse（18~22 g）6 groups are randomly divided into, respectively tests high dose group, tests middle dosage
Group, experiment low dose group, positive controls, negative control group, Normal group, every group 10, male and female half and half.Each group animal point
Gavage processing is not carried out according to following scheme：The Chinese medicine composition high dose group 1mg/ml obtained in embodiment 1, middle dose group are
0.5mg/ml, low dose group 0.25mg/ml, positive controls are gentamicin sulphate 1ml/kg, negative control group physiology salt
Water 0.2ml/10g body weight, Normal group are not dealt with, and feeding environment is identical, each group continuous use 7 days, 1 time a day, during which
Weighed daily.Oral administration in 7th day terminates rear 3h, remaining all mouse peritoneal injection inoculation large intestine bar except Normal group
Bacterium O101The mL of ordinary broth culture 0.4（Bacteria containing amount is about 2.4 × 108cfu）, all Mouse feeder conditions are identical.
2.2 observation index
Observe and record the incidence and clinical symptoms of each group animal.The diarrhoea number of recording laboratory animal is excrement situation, small
Death condition of mouse etc..Dead animal is carried out to analyse observation, and fixing organization makes section.
3. result
Each drug-treated group mouse death rate is substantially less than negative control group, shows the Chinese medicine composition of the present invention to artificial challenge
Escherichia coli O101The mouse of strain has preferable prevention effect.The mouse survival rate of middle dose group is 60%, and preventive effect is preferable.
Compared with negative control group, the lesion degree such as the heart of the mouse of senior middle school's low-dose drugs treatment group, liver, lung, kidney, small intestine has substantially
Mitigate.Concrete numerical value is shown in Table 3~4.
Therapeutic effect of the various dose group of table 3. to mouse
The influence that the various dose group of table 4. is showed diarrhea of mouse
5 Chinese medicine composition of the present invention of embodiment has good fungistatic effect in vitro to various pathogenic bacteria
1. test material：
The Chinese medicine composition of the 1.1 medicine embodiment of the present invention 1；Positive control gentamicin sulphate
1.2 bacterial strain：Clinical Isolates of Escherichia Coli O2, O78, O101, O149Separated and preserved by Jiangsu Mu Yuan animal drugs institute, greatly
The uncommon bacterium type strain (ATCC 25922) of intestines angstrom, staphylococcus aureus (ATCC 25923), pseudomonas aeruginosa, pig typhoid fever sramana
Salmonella, Salmonella choleraesuls, shigella dysenteriae clinical separation strain provide by Jiangsu Mu Yuan bio-pharmaceuticals engineering center.
2. test method：
Determine the inhibition zone of Chinese medicine composition of the present invention using cylinder-plate method, after good solid medium, each plate places 4 oxen
Tianjin cup, 200 μ L decoctions are added in each Oxford cup, antibacterial circle diameter size is determined after 37 DEG C of 18~24h of culture.
3. result of the test：After culture terminates, antibacterial circle diameter size is determined, line number is gone forward side by side according to statistics, the results are shown in Table 5.
Inhibition zone result of the Chinese medicine composition of table 5. to different strains（mm）
It can be found from experimental result, suppression during Chinese medicine composition crude drug content 1g/ml of the present invention to EHEC type strain
Bacterium circle is 32 mm, shows as extremely sensitivity, close with compareing gentamicin；And the EHEC for being clinically separated, green pus bar
The positive effect of bacterium and shigella dysenteriae, salmonella etc. is better than gentamicin；Inhibition zone to staphylococcus aureus is
20mm, show as intermediary.
Compared with the diarrhoea weanling pig of embodiment 6 adds Chinese medicine composition of the present invention and the effect for adding other treatment medicine
1. test material：
1.1 medicament：Chinese medicine composition in the embodiment of the present invention 2；Positive control Florfenicol, by herding a times health medicine company in Jiangsu
Co., Ltd provides
1.2 examination pig：This research is in two area of Jiangyan City Xian Min pig-breedings Specialty Co-operative Organization, Chang Mount livestock and poultry cultivation cooperative society pigs
Field is carried out, and watery diarrheas occur for two pig farm weanling pigs, and piglet is One's spirits are drooping, severe patient's dehydration even death.Select portion at random
Divide diarrhoea piglet, be equally divided into two groups, be respectively designated as 1 group of Jiangyan City's test group according to area, Jiangyan City tests 2 groups, every group 35；
Chang Mount tests 1 group, and Chang Mount tests 2 groups, and every group 22, each two test groups in pig farm are respectively raised, except the medicine added in feed
Other feeding and management condition all sames of thing difference.
1.3 medicines add：All piglets for participating in experiment feed same brand weanling pig complete feed, wherein
The Chinese medicine composition of the embodiment of the present invention 2 is added in two experiments, 1 group of weaning brash piglet feed in 1% ratio；And test 2 groups
By 0.05% addition florfenicol powder in pig starter feed.
2. test method：
2.1 gather the anal swab of diarrhoea piglet before medication, carry out the separation identification of laboratory pathogen.Select suitably
Culture medium carries out plate streaking inoculation, 37 DEG C of 24~48h of culture, observes the colonial morphology on flat board, chooses suspicious bacterium colony and carry out
Line purifying culture, Gram's staining, biochemical identification, the identification of serotype and pathogenicity etc..
The processing of 2.2 examination pigs：All experimental animals are carried out according to conventinal breeding management, continuous use 7 days, and observation is used
During medicine and be discontinued 3 days after pig improvement situation.
2.3 test data statistical dispositions：Testing crew observes spirit, body temperature and the excrement situation with record piglet at any time
Deng piglet mental restoration is normal after administration, and clinical symptoms, which are wholly absent, is considered as recovery from illness；The animal state of mind and excrement after administration
There is a change for the better is considered as cure rate, effective percentage and the death rate that piglet is effectively counted during off-test.
3 results
3.1 Experiment on therapy results
Preferable result is obtained, now arranges experimental result by the experiment of 10 days, and through test data statistical analysis, this experiment
Table 6 is as follows：
Treat comparative test result in the pig farm of table 6
From the test data of upper table 6：The Chinese medicine compound prescription powder test group of the present invention is added in the pig starter feed suffered from diarrhoea
Cure rate improve 10~20% than addition Florfenicol test group, it is efficient to improve about 10 % or so than Florfenicol group, simultaneously
At Jiangyan City test site with the test group mortality of animals that Florfenicol is treated than the death with Chinese medicine compound prescription powder of the present invention
Rate is high by 5.7%.
3.2 Pathogen identification results
MA culture mediums are inoculated in after carrying out increasing bacterium to the grice diarrhoea anus swab samples of collection, 24h or so, picking are cultivated in 37 DEG C
Suspicious bacterium colony carries out separation identification.Colonial morphology is the bacterium colony of the smooth moistening of piece red, through biochemical identification and Serotype Identification knot
Fruit shows that such bacterium colony is Escherichia coli, includes O altogether in the Escherichia coli that Jiangyan City pig farm is separated to78, O149Two kinds of serotypes,
Chang Mount hog man is to be separated to arrive O2, O78Two kinds of serotypes, and animal experiment shows that both serotypes are respectively provided with stronger cause a disease
Power, the Escherichia coli for showing to cause the two pig farm grice diarrhoeas are O respectively78, O149And O2, O78Serotype, specifically it is shown in Table 7.
The pig farm isolated strains qualification result of table 7
4. conclusion：By Escherichia coli O2、O78And O149The Chinese medicine group of the present invention is added in the weanling pig feed of caused diarrhoea
Compound can substantially cure grice diarrhoea and reduce the death rate, and its cure rate and the death rate have compared with adding Florfenicol group
Improve significantly.
The weanling pig of embodiment 7 adds Chinese medicine composition of the present invention compared with un-added effect
1. test material：
1.1 medicament：Chinese medicine composition in the embodiment of the present invention 2.
1.2 examination pigs select：This experiment is carried out in Jiangsu Chang Tai agriculture and animal husbandries Science and Technology Ltd., selects healthy wean at random
Piglet 160, is randomly divided into two groups, respectively tests 1 group, tests 2 groups, every group 80, raises respectively, all piglets remove feed
Other different feeding and management condition all sames of the medicine of middle addition.
1.3 medicines add：All piglets for participating in experiment feed same brand weanling pig complete feed, wherein
Test the Chinese medicine composition for adding the present invention in 1 group of weanling pig feed in 0.5% ratio；Test do not added in 2 groups of feeds it is any
Additive.
2. test method：
The processing of 2.1 examination pigs：Test 1,2 group of animal to carry out according to conventinal breeding management, continuous use 30 days.
2.2 test data statistical dispositions：Testing crew observes the hair with the mental status of record piglet and diarrhoea at any time
State of an illness condition, formal test start to weigh to all experimental animals in first day, all animals are weighed during off-test.
3. experimental result：By the experiment of 30 days, and it is as follows through test data statistical analysis, experimental result list 8：
Table 8 tests 1,2 group to preventing post-weaning diarrhea Comparative result
From the test data of upper table 8：The Chinese medicine composition test group ratio of the present invention is added in the feed of healthy weanling pig
The test group diarrhea disease percentage low 6.25% of any additive is not added, and the Chinese medicine compound prescription of the present invention is added at the end of feeding in 30 days
The test group of powder about increases by 2.17 kg than un-added average weight gain.
4. conclusion：The Chinese medicine compound prescription powder of the present invention is added in the feed of healthy weanling pig than the piglet do not added
Diarrhea disease percentage substantially reduces, and can be obviously promoted piglet weightening, contributes to the raising of economic benefit.
Claims (10)
- A kind of 1. Chinese medicine composition for being used to prevent and treat diarrhea of weaned piglets, it is characterised in that：Said preparation be by the Chinese bulbul, Jatamans valeriana rhizome, fortune paulownia flower are the preparation that bulk drug is prepared, and raw material medicaments in part by weight meter includes：Chinese bulbul 20-30 parts, fortune paulownia flower 10-25 parts, jatamans valeriana rhizome 15-25 parts.
- 2. it is according to claim 1 prevention and treatment diarrhea of weaned piglets Chinese medicine composition, it is characterised in that be by by It is prepared according to the following raw material of parts by weight meter：25 parts of the Chinese bulbul, 11 parts of fortune paulownia flower, 20 parts of jatamans valeriana rhizome.
- 3. it is according to claim 1 prevention and treatment diarrhea of weaned piglets Chinese medicine composition, it is characterised in that be by by It is prepared according to the following raw material of parts by weight meter：28 parts of the Chinese bulbul, 17 parts of fortune paulownia flower, 18 parts of jatamans valeriana rhizome.
- 4. it is according to claim 1 prevention and treatment diarrhea of weaned piglets Chinese medicine composition, it is characterised in that be by by It is prepared according to the following raw material of parts by weight meter：30 parts of the Chinese bulbul, 20 parts of fortune paulownia flower, 15 parts of jatamans valeriana rhizome.
- 5. the preparation process according to the Chinese medicine composition of the prevention and treatment diarrhea of weaned piglets described in Claims 1-4 is：Take Each raw material needed for prescription, is crushed respectively, 120 mesh sieves is crossed, according to the prevention and treatment weanling pig described in Claims 1-4 The parts by weight of the Chinese medicine composition of diarrhoea are mixed, and are dispensed and are produced after mixing.
- 6. a kind of application for being used to prevent and treat the Chinese medicine composition of diarrhea of weaned piglets according to described in claim 1-4, It is characterized in that：Said composition is mainly used in the prevention and treatment mainly diarrhea of weaned piglets as caused by staphylococcus aureus.
- 7. a kind of application for being used to prevent and treat the Chinese medicine composition of diarrhea of weaned piglets according to described in claim 1-4, It is characterized in that：Said composition is mainly used in prevention and treatment mainly by the microbial diarrhea of weaned piglets of P. aeruginosa.
- 8. a kind of application for being used to prevent and treat the Chinese medicine composition of diarrhea of weaned piglets according to described in claim 1-4, It is characterized in that：Said composition is mainly used in the prevention and treatment mainly diarrhea of weaned piglets as caused by shigella dysenteriae.
- 9. a kind of application for being used to prevent and treat the Chinese medicine composition of diarrhea of weaned piglets according to described in claim 1-4, It is characterized in that：Said composition is mainly used in prevention and treatment and mainly caused by moscow' typhisuis, Salmonella choleraesuls Diarrhea of weaned piglets.
- 10. a kind of application for being used to prevent and treat the Chinese medicine composition of diarrhea of weaned piglets according to described in claim 1-4, It is characterized in that：Said composition is mainly used in prevention and treatment mainly by Escherichia coli O2、O78、O149、O101Caused wean is young Diarrhea of pigs.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114601880A (en) * | 2022-04-15 | 2022-06-10 | 苏州农业职业技术学院 | Valeriana jatamansi jones compound preparation for resisting piglet diarrhea |
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| CN102764392A (en) * | 2012-08-14 | 2012-11-07 | 天津生机集团股份有限公司 | Traditional Chinese medicine composite for preventing and curing diarrhea of weaned pig and preparation method thereof |
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