CN108186752A - A kind of herbal medicine for treating fowl bacterial diarrhea and preparation method thereof - Google Patents
A kind of herbal medicine for treating fowl bacterial diarrhea and preparation method thereof Download PDFInfo
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- CN108186752A CN108186752A CN201810238951.0A CN201810238951A CN108186752A CN 108186752 A CN108186752 A CN 108186752A CN 201810238951 A CN201810238951 A CN 201810238951A CN 108186752 A CN108186752 A CN 108186752A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The invention discloses a kind of herbal medicines for treating fowl bacterial diarrhea and preparation method thereof, it is that the bulk pharmaceutical chemicals matched by following weight are prepared：30 40 parts of purslane, 30 40 parts of the coptis, 20 40 parts of Radix Glycyrrhizae.Specific preparation process is as follows：（1）Purslane, the coptis, licorice medicinal materials are prepared by weight, screening cleaning；（2）Above-mentioned each raw material is crushed, is crushed to 20 30 mesh；（3）It extracts to obtain extracting solution using super critical extraction, extraction solvent is drinking water；（4）It is 1.05 1.10 that said extracted liquid is concentrated into density, is got product after filtering.The present invention is preferably fewer but better in terms of prescription screening, and ingredient curative for effect carries out compatibility, reduces use cost；Using modernization extractive technique, effective component of chinese medicine is extracted, product design is high, significant effect；The clinical animal doctor for not having theory of traditional Chinese medical science much and cultural technique personnel can carry out direction of medication usage by modern medicine.
Description
Technical field
The present invention relates to the field of Chinese medicines, more particularly to a kind of herbal medicine for treating fowl bacterial diarrhea and its preparation side
Method.
Background technology
In Modern Animal Husbandry, livestock and poultry intestinal canal diseases are disease occurred frequently, and wherein bacterial diarrhea is the most common type disease,
Large dosage of antibiotic control is used for a long time, huge hidden danger is brought to environment and livestock product safety, while bacterial drug resistance is produced
Life also brings great risk to human health.China forbids adding the antibiosis such as colistine sulfate in feed at present
Element.The pathogenic bacteria for causing fowl bacterial diarrhea are mainly Escherichia coli and salmonella.Past main control method is to support
The antibiotic such as a large amount of colistin sulfate, neomycin, apramycin, Florfenicol are added to prevent in the scene of growing.But with antibiosis
Long-term a large amount of uses of element, one side bacterium may be transmitted to human disease bacterium to drug resistant, be brought to human health
Great risk；On the other hand in order to reach effect overdose using bringing huge hidden danger to livestock product safety.In order to ensure
Livestock product safety, many policies of Ministry of Agriculture's appearance, which are limited in feed, adds antibiotic.It is led after feed factory limitation antibiotic usage
Farm's morbidity is caused to increase, seriously affects feed quality and culture efficiency, while cultivation site medication increases, similar situation is in Europe
Man of ally also occurred.Therefore farm is very big to antibiotic substitute demand.
The animal husbandry application of Chinese medicine has had long history, but further investigate fewer, Chinese veterinarian in use
Product be all in the past crush or it is thick carry based on, herbal medicine product is generally based on diagnosis and treatment, clinical many animal doctors and cultivation skill
Art personnel do not have theory of traditional Chinese medical science, are difficult to use, while prescriptions of traditional Chinese medicine general classes polygamy, than complicated, use cost is high, operation
It is complicated.
Invention content
In order to overcome the above-mentioned deficiencies of the prior art, Chinese medicine is used only with traditional Chinese medicine prescription for current livestock
Simple to crush or simply decoct, applicant combines modern advanced extraction process and has carried out Improvement, employs and is suitble to the group
The advanced extraction process of side provides herbal medicine and its preparation side that a kind of energy substitute antibiotics are used to treat fowl bacterial diarrhea
Method.
The technical solution adopted in the present invention is as follows：
（1）It is good to screen antibacterial, anti-inflammatory effect, to Gram-negative bacteria（Such as Escherichia coli, salmonella）Sensitive Chinese medicine：Dent
Amaranth, the coptis, Radix Glycyrrhizae；
（2）The compatibility for studying drug promotes antibacterial action and the effect of clinical drug effect, determines that purslane, the coptis, Radix Glycyrrhizae are matched
5 ratios；
（3）Extraction process is studied, establishes suitable extracting method, ensures that effective ingredient extracts to the greatest extent,
Make product extraction process.
The technical solution specifically used for：
A kind of herbal medicine for treating fowl bacterial diarrhea, it is that the bulk pharmaceutical chemicals matched by following weight are prepared：Purslane
30-40 parts, 30-40 parts of the coptis, 20-40 parts of Radix Glycyrrhizae.
A kind of preparation method for the herbal medicine for treating fowl bacterial diarrhea, specific preparation process are as follows：
（1）Purslane, the coptis, licorice medicinal materials are prepared by weight, screening cleaning；
（2）Above-mentioned each raw material is crushed, is crushed to 20-30 mesh；
（3）It extracts to obtain extracting solution using super critical extraction, extraction solvent is drinking water；
（4）Said extracted liquid is concentrated into density as 1.05-1.10, is got product after filtering.
Further, the step（3）Using dynamic process for super-critical extracting, solvent is 10 with raw material ratio:1, during extraction
Between 2 hours, 70-80 DEG C of Extracting temperature.
Further, the step（4）Middle extracting solution concentration is each to imitate vacuum degree and evaporating temperature point using Three-effect concentration device
It is not：One effect -0.04 ~ -0.07MPa, 85 DEG C；Two effect -0.06 ~ -0.08MPa, 75 DEG C, triple effect -0.07 ~ -0.10MPa, 65 DEG C.
Operation principle：Purslane mainly has the effect of clearing heat and detoxicating, to remove heat from the blood and relieve diarrhea, is treating stranguria, and the coptis has clearind deficient heat, except infantile malnutrition due to digestive disturbances or intestinalparasites
The effect of heat, clearing away damp-heat, Radix Glycyrrhizae mainly cure mainly the functions such as clearing heat and detoxicating, expelling phlegm and arresting coughing, gastral cavity abdomen, and three's collective effect is for anti-
Control fowl bacterial diarrhea have effects that it is apparent.
The method have the benefit that：
1st, the present invention is preferably fewer but better in terms of prescription screening, and ingredient curative for effect carries out compatibility, reduces use cost；
2nd, the present invention is extracted effective component of chinese medicine, product design is high, significant effect using modernization extractive technique；
3rd, the theoretical research that the present invention is combined using Chinese and Western, clinic much do not have the animal doctor of theory of traditional Chinese medical science and cultural technique personnel
Direction of medication usage can be carried out by modern medicine.
Present invention is mainly used for prevention fowl bacterial diarrhea, curative effect really can replace antibiotic, be applicable to completely
Current livestock is to reduce in the use of antibiotic or nonreactive cultivation to replace antibiotic, has without side-effects, the markedly fast of safety,
The features such as symptom disappears soon, and effect is rapid.
Specific embodiment
Further to illustrate the effect of the technological means taken of the present invention and acquirement, with reference to preferred embodiment,
To technical scheme of the present invention, clear and complete description is carried out.
Embodiment 1
Cleaning is screened after weighing 35 parts of purslane, 35 parts of the coptis, 30 parts of Radix Glycyrrhizae respectively in parts by weight；By above-mentioned each raw material powder
It is broken, it is crushed to 30 mesh；It is extracted using super critical extraction, extraction solvent is drinking water, and solvent used is 10 with raw material ratio:
1, heating temperature is 80 DEG C, 2 hours extraction times；It is 1.05 that said extracted liquid is concentrated into density.Method for concentration uses triple effect
Inspissator, each effect vacuum degree and evaporating temperature are：Each effect vacuum degree and evaporating temperature are：One effect -0.04MPa, 85 DEG C；Two effects-
0.06MPa, 75 DEG C, triple effect -0.07MPa, 65 DEG C.Liquid is concentrated into relative density 1.05, filters to obtain the final product.
Embodiment 2
Weigh 40 parts of purslane, 40 parts of the coptis, 20 parts of screening cleanings of Radix Glycyrrhizae respectively in parts by weight；Above-mentioned each raw material is crushed,
It is crushed to 25 mesh；It is extracted using super critical extraction, extraction solvent is drinking water, and solvent used is 10 with raw material ratio:1,
Heating temperature is 70 DEG C, 2 hours extraction times；It is 1.10 that said extracted liquid is concentrated into density.Method for concentration is dense using triple effect
Contracting device, each effect vacuum degree and evaporating temperature are：Each effect vacuum degree and evaporating temperature are：One effect 0.07MPa, 85 DEG C；Two effects
0.08MPa, 75 DEG C, triple effect 0.10MPa, 65 DEG C.Liquid is concentrated into relative density 1.10, filters to obtain the final product.
Embodiment 3
Weigh 30 parts of purslane, 30 parts of the coptis, 40 parts of screening cleanings of Radix Glycyrrhizae respectively in parts by weight；Above-mentioned each raw material is crushed,
It is crushed to 20 mesh；It is extracted using super critical extraction, extraction solvent is drinking water, and solvent used is 10 with raw material ratio:1,
Heating temperature is 75 DEG C, 2 hours extraction times；It is 1.08 that said extracted liquid is concentrated into density.Method for concentration is dense using triple effect
Contracting device, each effect vacuum degree and evaporating temperature are：Each effect vacuum degree and evaporating temperature are：One effect 0.05MPa, 85 DEG C；Two effects
0.03MPa, 75 DEG C, triple effect 0.03MPa, 65 DEG C.Liquid is concentrated into relative density 1.10, filters to obtain the final product.
Embodiment 4
Weigh 33 parts of purslane, 36 parts of the coptis, 35 parts of screening cleanings of Radix Glycyrrhizae respectively in parts by weight；Above-mentioned each raw material is crushed,
It is crushed to 28 mesh；It is extracted using super critical extraction, extraction solvent is drinking water, and solvent used is 10 with raw material ratio:1,
Heating temperature is 78 DEG C, 2 hours extraction times；It is 1.03 that said extracted liquid is concentrated into density.Method for concentration is dense using triple effect
Contracting device, each effect vacuum degree and evaporating temperature are：Each effect vacuum degree and evaporating temperature are：One effect 0.02MPa, 85 DEG C；Two effects
0.05MPa, 75 DEG C, triple effect 0.05MPa, 65 DEG C.Liquid is concentrated into relative density 1.03, filters to obtain the final product.
Clinical observation：
By carrying out treatment observation to piglet of 150 many cases with dysentery, it is administered 1.5g/Kg/ times by piglet weight, daily administration
3 times.With the not main judge index of times of defecation and state, with reference to the state of mind, autonomous actions consciousness and emulsus state is eaten to cure
Evaluation criterion, after successive administration 2 days, the times of defecation of piglet is 1 time, and the state of mind is preferable, can arbitrarily walk about, eat breast
Restore normal, basic forming of defecating, cure rate 93%；After successive administration 3 days, cure rate 97%.
Embodiment described above only expresses the specific embodiment of the present invention, and description is more specific and detailed, but simultaneously
Cannot the limitation to the scope of the claims of the present invention therefore be interpreted as.It should be pointed out that for those of ordinary skill in the art
For, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the guarantor of the present invention
Protect range.
Claims (4)
1. a kind of herbal medicine for treating fowl bacterial diarrhea, which is characterized in that it is the bulk pharmaceutical chemicals system matched by following weight
It is standby to form：30-40 parts of purslane, 30-40 parts of the coptis, 20-40 parts of Radix Glycyrrhizae.
2. a kind of preparation method for the herbal medicine for preparing treatment fowl bacterial diarrhea described in claim 1, which is characterized in that
Specific preparation process is as follows：
（1）Purslane, the coptis, licorice medicinal materials are prepared by weight, screening cleaning；
（2）Above-mentioned each raw material is crushed, is crushed to 20-30 mesh；
（3）It extracts to obtain extracting solution using super critical extraction, extraction solvent is drinking water；
（4）Said extracted liquid is concentrated into density as 1.05-1.10, is got product after filtering.
A kind of 3. preparation method for the herbal medicine for treating fowl bacterial diarrhea according to claim 2, which is characterized in that institute
State step（3）Using dynamic process for super-critical extracting, solvent is 10 with raw material ratio:1,2 hours extraction times, Extracting temperature 70-
80℃。
A kind of 4. preparation method for the herbal medicine for treating fowl bacterial diarrhea according to claim 2, which is characterized in that institute
State step（4）Middle extracting solution concentration respectively imitates vacuum degree and evaporating temperature is respectively using Three-effect concentration device：One effect -0.04 ~ -
0.07MPa, 85 DEG C；Two effect -0.06 ~ -0.08MPa, 75 DEG C, triple effect -0.07 ~ -0.10MPa, 65 DEG C.
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| CN201810238951.0A CN108186752A (en) | 2018-03-22 | 2018-03-22 | A kind of herbal medicine for treating fowl bacterial diarrhea and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112472736A (en) * | 2020-11-25 | 2021-03-12 | 江西合盈生物科技有限公司 | Medium-short chain fatty acid and thousand-mesh Chinese herbal medicine compound preparation for livestock and poultry anti-diarrhea, preparation method and use method |
| CN112568323A (en) * | 2020-12-10 | 2021-03-30 | 无锡正大生物股份有限公司 | Ampelopsis grossedentata flavone extract for resisting bacteria, diminishing inflammation and promoting growth of livestock and poultry as well as production method and application thereof |
| CN114796326A (en) * | 2021-01-22 | 2022-07-29 | 成都抚南医药有限公司 | A Chinese medicinal composition for treating dermatoses |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112472736A (en) * | 2020-11-25 | 2021-03-12 | 江西合盈生物科技有限公司 | Medium-short chain fatty acid and thousand-mesh Chinese herbal medicine compound preparation for livestock and poultry anti-diarrhea, preparation method and use method |
| CN112568323A (en) * | 2020-12-10 | 2021-03-30 | 无锡正大生物股份有限公司 | Ampelopsis grossedentata flavone extract for resisting bacteria, diminishing inflammation and promoting growth of livestock and poultry as well as production method and application thereof |
| CN114796326A (en) * | 2021-01-22 | 2022-07-29 | 成都抚南医药有限公司 | A Chinese medicinal composition for treating dermatoses |
| CN114796326B (en) * | 2021-01-22 | 2023-09-15 | 成都抚南医药有限公司 | A Chinese medicinal composition for treating dermatoses |
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