CN1927272A - Medicament for animals with heat clearing and detoxicating, detumescence and obstruction removing functions and preparing method thereof - Google Patents
Medicament for animals with heat clearing and detoxicating, detumescence and obstruction removing functions and preparing method thereof Download PDFInfo
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- CN1927272A CN1927272A CN 200510015052 CN200510015052A CN1927272A CN 1927272 A CN1927272 A CN 1927272A CN 200510015052 CN200510015052 CN 200510015052 CN 200510015052 A CN200510015052 A CN 200510015052A CN 1927272 A CN1927272 A CN 1927272A
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- fructus forsythiae
- forsythia
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Abstract
The invention relates to a kind of animal agentia and the preparative of it, which has something to do with the animal drug technology. The material of the agentia is forsythia, which can relieve the fever, deintoxicate, lessen swelling and eliminate stagnation. The making procedures go as follows: remove the impurities of forsythia and clean it thoroughly; cut it into several sections and crush the forsythia; extract the smashed forsythia; mix the filtered solutions together; dry the solution into powder and smash it into refined forsythia powder. The extracting procedure includes two steps mainly, the first step is extracting the material in solution at ph2-5(adjusted by 10% acid solution) for 2 hours; the second step is extracting the material in solution at ph8-9(adjusted by 10% acid solution) for 8-9 hours. The agentia can treat the loimia of livestocks and poultries very effectively. The processing technology adopts the water-extracting method, besides it adopts acids before alkaline during extracting so that it can retain the effective ingredient of the drug. The effective ingredients of the refined powder have overcome the absorption problem of forsythia, so that the agentia can increase the economic benefits and decrease the producing cost of the animal agentia.
Description
Technical field
The invention belongs to the technical field of herbal medicine, the present invention relates to the Chinese crude drug Fructus Forsythiae is the animal medicament and the method for making thereof of a kind of heat-clearing and toxic substances removing of feedstock production, dispersing swelling and dissipating binds function.
Background technology
Chinese medicine and pharmacy is one of important component part in the cultural treasure-house of China's medicine, and Chinese herbal medicine then is the culture rarity of China.Aspect animal medicine, traditional Chinese veterinary medicine is also playing crucial effect aspect the Clinics and Practices of livestock and poultry.
(the different name drought connects son to Fructus Forsythiae, comes from " property of medicine opinion "; Stick up son greatly, stick up greatly, come from Tang Materia Medica; Ghost comes from " Chinese medicinal herbal "; Different sticking up come from " elegant ") be one of heat-clearing and toxic substances removing the most frequently used in the Chinese medicine for animals, dispersing swelling and dissipating binds medical material.2000 editions veterinary drug allusion quotations are recorded its medical material and are used for the heating of poultry epidemic febrile disease, diseases such as skin ulcer general edema with yellowish skin poison.
In clinical use; because modern large-scale cultivation; directly the Chinese medicine crude drug is carried out the mixed feeding administration and usually cause problems such as administration inconvenience, abnormal smells from the patient is dense, absorbance is low; make the Fructus Forsythiae drug effect not bring into play fully; and take common decocting in water precipitate with ethanol extraction method to extract as a Pharmacopoeia of the People's Republic of China of version " Fructus Forsythiae extract " preparation in 2005; not only waste a large amount of ethanol, also lost the mass efficient composition simultaneously.Do not retrieve at present the application of the smart powder of Fructus Forsythiae on livestock and poultry pestilence as yet, the extractive technique of Fructus Forsythiae usually is the extractive technique of human medicine, and technical sophistication, cost height are used for poultry medication and uneconomical; And the said extracted process usually can be removed the nutritional labelings such as protein in the Chinese medicine, and this has improved aquaculture cost virtually again for livestock and poultry cultivation.
Summary of the invention
To the objective of the invention is in order addressing the above problem, a kind of smart powder veterinary formulations of Fructus Forsythiae with functions such as heat-clearing and toxic substances removing, dispersing swelling and dissipating binds to be provided.Be used to cure mainly diseases such as animal enteritis, dysentery, yellow and white dysentery of piglet, pneumonia, Pullorum Disease, infectious coryza of chicken, but mixed feeding also can be mixed the drink administration, simultaneously again can be as the raw material of further preparation.Chemotherapy is generally adopted in bacillary, the viral infection of treatment domestic animal at present, heavy dose of chemical drugs that feeds also makes the intravital normal flora of machine suffer to destroy and imbalance in the treatment disease, causes producing in the body residual in animal foodstuff of Resistant strain and medicine.Fructus Forsythiae nature and flavor hardship, cold can be gone into the heart, lung, large intestine, urinary bladder channel, and gram positive bacteria and negative bacterium are had certain inhibitory action.And the present invention---the upper respiratory tract infection that the smart powder of Fructus Forsythiae causes for bacterial virus mixed infection can comparatively fast be eliminated symptom, promotes body recovery.The smart powder side effect of Fructus Forsythiae is little, the no obvious toxic and side effects in oral back, and do not produce drug resistance after using, body is interior without any drug residue.
Technical scheme of the present invention is: a kind of application and the method for making thereof of the smart powder of Fructus Forsythiae on poultry with heat-clearing and toxic substances removing, dispersing swelling and dissipating binds function.
The invention provides a kind of have heat-clearing and toxic substances removing, dispersing swelling and dissipating binds function animal medicament, it is characterized in that this medicament is is the medicament that raw material is made by Fructus Forsythiae.
Dose processing method: Fructus Forsythiae is removed impurity afterwash, cutting, grind then, cross 60 mesh sieves, standby; At first the Fructus Forsythiae after handling is extracted: with the water extraction of 8 times of amounts of medical material, extracting temperature is 95 ± 3 ℃, and being adjusted to pH with 10% acid for the first time is 2-5, decocts 2 hours; Extract for the second time 8 times that will water add to medical material weight, regulating pH with 10% alkali is 8-9, and extraction time is 1.5 hours, and medicinal liquid filters the back merging respectively, and filtrate is concentrated into relative density and is about 1.34-1.36g/cm
370 ℃ thick paste, thick paste carries out vacuum drying, pulverizes; Or merging rear filtrate, to be concentrated into relative density be 1.10-1.20g/cm
370 ℃ clear paste, spray drying promptly get the smart powder of Fructus Forsythiae, and yield is 12.9%-19.5%.
A kind of method for making with animal medicament of heat-clearing and toxic substances removing, dispersing swelling and dissipating binds function, comprise the Fructus Forsythiae medical material is removed impurity afterwash, cutting, grind then, cross 60 mesh sieves, standby, it is characterized in that at first the Fructus Forsythiae after handling being extracted: with the water extraction of 8 times of amounts of medical material, extracting temperature is 95 ± 3 ℃, for the first time being adjusted to pH with 10% acid is 2-5, decocts 2 hours; Extract for the second time 8 times that will water add to medical material weight, pH is 8-9 with the adjusting of 10% alkali, and extraction time is 1.5 hours; Medicinal liquid filters the back respectively and merges, and promptly gets the Fructus Forsythiae extracting solution, and the Fructus Forsythiae extracting solution is concentrated into relative density and is about 1.34-1.36g/cm
370 ℃ thick paste, thick paste carries out vacuum drying, pulverizes; Or the Fructus Forsythiae extracting solution to be concentrated into relative density be 1.10-1.20g/cm
370 ℃ clear paste, spray drying promptly get the smart powder (yield is 12.9%-19.5%) of Fructus Forsythiae.
Have heat-clearing and toxic substances removing, dispersing swelling and dissipating binds function animal medicament and a method for making thereof according to described, it is characterized in that described acid is hydrochloric acid or lactic acid; Alkali is to regulate pH value with sodium hydroxide.
Finished product of the present invention can be made multiple dosage form as required, adds appropriate amount of auxiliary materials and can be used as injection, is used for intramuscular injection; Directly medicinal can mixed feeding or mix drink; Carry out breast or intestinal perfusion after also can be water-soluble with powder.
Extracorporeal bacteria inhibitor test: Fructus Forsythiae is a broad spectrum antibiotic, and leptospira is also had inhibitory action.Test as follows:
1, gets from the isolating staphylococcus aureus of clinical case, Diplococcus pneumoniae, escherichia coli, to 4 ℃ of refrigerators preservations.
2, the smart powder of getting after the spray drying of Fructus Forsythiae is an amount of, and penicillin, amikacin, three kinds of medicines of cefalexin make drug sensitive test paper, preserves standby in 4 ℃ of refrigerators.
3, the strain of picking out more than the general is seeded on the bacteria culture media and cultivated 12 hours, selects colonies typical, carries out drug sensitive test, according to the size of inhibition zone, judges the sensitivity of pathogenic bacteria to medicine.
Criterion is antibacterial circle diameter: 0～9mm drug resistance; It is quick during 10～19mm is low; 20mm is above to be Gao Min.
Four kinds of medicines such as the smart powder of Fructus Forsythiae are to the drug resistance experiment of following three kinds of antibacterials
As can be seen from the above table, except that the smart powder of Fructus Forsythiae, other three kinds of medicines all show as drug resistance or hypoallergenic to three kinds of pathogenic bacterias, and the smart powder of therefore provable Fructus Forsythiae has stronger inhibitory action to above-mentioned pathogenic bacteria.
The smart powder of the present invention's Fructus Forsythiae for animals is widely used in the multiple common bacteria infectious disease of various different animals on the veterinary clinic, as enteritis, dysentery, piglet pujos blancos, Pullorum Disease, fish enteritis, baby swine paratyphoid etc., also can be used for respiratory tract infectious disease, as pneumonia, pulmonary abscess, and urinary tract infection, encephalitis, infections are swollen etc.If can accomplish diagnosis early, early find that early treatment cooperates and strengthens feeding and management, cure rate generally can be more than 90%, and suitable dose and method be by 0.05～0.15g/kg body weight, medication every day once, logotype got final product in 3～5 days.
The invention has the beneficial effects as follows: by the checking of a large amount of animal clinic trial, the present invention treats the eqpidemic disease that domestic animal, poultry cause because of infection such as antibacterial or viruses excellent curative, has played the effect of heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.
Since process using water extraction of the present invention, the method for sour earlier back alkali, water temperature raising degree is higher, has kept the effective ingredient in the medicine, and the active component in the smart powder has overcome the difficult difficulty that absorbs of Fructus Forsythiae crude drug.After water is carried, do not adopt alcohol deposition method, kept the nutritions such as protein in the medicine, after poultry are taken in, help the growth of poultry, thereby improved the economic benefit of culturing, reduced the medicine production cost.Generally speaking reduced aquaculture cost, solved because of Resistant strain exists and used the inoperative difficulty of antibiotic therapy.Be used for the treatment of domestic animal, poultry because of the infectiousness eqpidemic disease has excellent curative, played the effect of heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.
The specific embodiment:
Embodiment 1: get Fructus Forsythiae medical material 100kg, with the Fructus Forsythiae raw material wash on request, pick up, cut, dry, to pulverize the back standby.Extracting temperature is 95 ± 3 ℃, and amount of water is 8 times of medical material weight for the first time, the acid for adjusting pH to 3 with 10%, and extraction time is 2 hours; For the second time amount of water still be 8 times of medical material weight, and with 10% alkali adjusting pH to 8.5, extraction time is 1 hour.80 ℃ of thickening temperatures, vacuum-0.09Mpa, being concentrated into proportion is 1.20g/cm
3(70 ℃).Spray drying or vacuum decompression crushed after being dried promptly get the smart powder 15.3kg (yield is 15.3%) of Fructus Forsythiae.
Certain chicken house chicken group infects chronic respiratory tract disease, and symptoms such as shedding tears appears in most of chicken group, sneeze, cough are not seen obvious improvement with effect after the Drug therapy of treatment Mycoplasma.Adopt medicine of the present invention, 100g converts water 100kg, freely drinks water, carry out five days by a definite date treatment after, most of sick fowl disease close friend changes, the symptom cure rate that disappears substantially has been dealt into 92%.
Embodiment 2: get Fructus Forsythiae medical material 100kg, method for making is with embodiment 1.Can get the smart powder 16.1kg (yield is 16.1%) of Fructus Forsythiae after the extraction.Certain pig farm is because of infecting Escherichia coli, and state of an illness weight differs, and after taking measures to carry out urgent immunity, adds medicine of the present invention, 1g/kg feedstuff, logotype 5 days in feedstuff.Most of sick swine diseases feelings begin to take a turn for the better gradually after 5 days, normal feed of beginning and drinking-water.After continuing to strengthen treatment, be almost recovered.
Claims (3)
1, a kind of have heat-clearing and toxic substances removing, a dispersing swelling and dissipating binds function animal medicament, it is characterized in that this medicament is is the medicament that raw material is made by Fructus Forsythiae
Dose processing method: Fructus Forsythiae is removed impurity afterwash, cutting, grind then, cross 60 mesh sieves, standby; At first the Fructus Forsythiae after handling is extracted: with the water extraction of 8 times of amounts of medical material, extracting temperature is 95 ± 3 ℃, and being adjusted to pH with 10% acid for the first time is 2-5, decocts 2 hours; Extract for the second time 8 times that will water add to medical material weight, regulating pH with 10% alkali is 8-9, and extraction time is 1.5 hours, and medicinal liquid filters the back merging respectively, and filtrate is concentrated into relative density and is about 1.34-1.36g/cm
370 ℃ thick paste, thick paste carries out vacuum drying, pulverizes; Or filtrate to be concentrated into relative density be 1.10-1.20g/cm
370 ℃ clear paste, spray drying promptly get the smart powder of Fructus Forsythiae, and yield is 12.9%-19.5%.
2, a kind of method for making with animal medicament of heat-clearing and toxic substances removing, dispersing swelling and dissipating binds function, comprise the Fructus Forsythiae medical material is removed impurity afterwash, cutting, grind then, cross 60 mesh sieves, standby, it is characterized in that at first the Fructus Forsythiae after handling being extracted: with the water extraction of 8 times of amounts of medical material, extracting temperature is 95 ± 3 ℃, for the first time being adjusted to pH with 10% acid is 2-5, decocts 2 hours; Extract for the second time 8 times that will water add to medical material weight, pH is 8-9 with the adjusting of 10% alkali, and extraction time is 1.5 hours; Medicinal liquid filters the back respectively and merges, and promptly gets the Fructus Forsythiae extracting solution, and the Fructus Forsythiae extracting solution is concentrated into relative density and is about 1.34-1.36g/cm
370 ℃ thick paste, thick paste carries out vacuum drying, pulverizes; Or filtrate to be concentrated into relative density be 1.10-1.20g/cm
370 ℃ clear paste, spray drying promptly get the smart powder of Fructus Forsythiae, and yield is 12.9%-19.5%.
3, describedly have heat-clearing and toxic substances removing, dispersing swelling and dissipating binds function animal medicament and a method for making thereof according to claim 1 and 2, it is characterized in that described acid is hydrochloric acid or lactic acid; Alkali is to regulate pH value with sodium hydroxide.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510015052 CN1927272A (en) | 2005-09-09 | 2005-09-09 | Medicament for animals with heat clearing and detoxicating, detumescence and obstruction removing functions and preparing method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200510015052 CN1927272A (en) | 2005-09-09 | 2005-09-09 | Medicament for animals with heat clearing and detoxicating, detumescence and obstruction removing functions and preparing method thereof |
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| CN1927272A true CN1927272A (en) | 2007-03-14 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102920902A (en) * | 2011-11-03 | 2013-02-13 | 青岛康地恩药业股份有限公司 | Avian colibacillosis treatment traditional Chinese medicine and preparation method thereof |
| CN104840869A (en) * | 2015-05-18 | 2015-08-19 | 山东新希望六和集团有限公司 | Drug composition for treating pig paratyphoid fever and preparation method thereof |
| CN115581726A (en) * | 2022-11-10 | 2023-01-10 | 河北象大合众生物科技有限公司 | Fine extraction method of veterinary forsythia suspense extract |
-
2005
- 2005-09-09 CN CN 200510015052 patent/CN1927272A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102920902A (en) * | 2011-11-03 | 2013-02-13 | 青岛康地恩药业股份有限公司 | Avian colibacillosis treatment traditional Chinese medicine and preparation method thereof |
| CN104840869A (en) * | 2015-05-18 | 2015-08-19 | 山东新希望六和集团有限公司 | Drug composition for treating pig paratyphoid fever and preparation method thereof |
| CN115581726A (en) * | 2022-11-10 | 2023-01-10 | 河北象大合众生物科技有限公司 | Fine extraction method of veterinary forsythia suspense extract |
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