CN103417660A - Preparation method of Chinese goldthread rhizome granules and application of Chinese goldthread rhizome granules to livestock and poultry - Google Patents
Preparation method of Chinese goldthread rhizome granules and application of Chinese goldthread rhizome granules to livestock and poultry Download PDFInfo
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- CN103417660A CN103417660A CN2013103319688A CN201310331968A CN103417660A CN 103417660 A CN103417660 A CN 103417660A CN 2013103319688 A CN2013103319688 A CN 2013103319688A CN 201310331968 A CN201310331968 A CN 201310331968A CN 103417660 A CN103417660 A CN 103417660A
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Abstract
The invention relates to a preparation method and application of Chinese goldthread rhizome granules. The Chinese goldthread rhizome granules are prepared by the following steps: extracting by a water-boiling method; precipitating at a low temperature and filtering to remove most impurities; performing ultrafiltration on the filtrate through a 100,000-Dalton ultrafiltration column to remove impurities thoroughly; drying the material under reduced pressure until the concentration of the material reaches a certain concentration, and spray-drying; adding auxiliary materials into the spray-dried powder. The Chinese goldthread rhizome granules are used for treating bacterial enteritis of livestock and poultry. The Chinese goldthread rhizome granules are pure traditional Chinese medicine preparations, are safe, effective and non-toxic, is free from residue and drug resistance, and suitable for intensive cultivation and green cultivation at present.
Description
Technical field
The present invention relates to a kind of Rhizoma Coptidis granule, particularly the preparation method of Rhizoma Coptidis granule and in the application of control fowl bacterial enteritis.
Background technology
Avian enteritis is that the poultry intestinal mucosa is inflamed, take clinically the digestive function obstacle, diarrhoea be feature.Primary disease all can occur the poultry at various ages, but multiple with the young fowl in 2～3 week age.Young fowl main manifestations is lethargy, and body temperature reduces, and appetite descends or do not eat, and the feather pine disorderly, slow-witted vertical, normal together crowded, and can see the nephrodinic collar extension of disease fowl and again and again sharply shrink, diarrhoea, row has white, yellow, green, brown color or secondary colour loose stool, and the perianal feather sticks feces.Happiness drinking-water, finally, because of dehydration, die of exhaustion.
Domestic animal enteritis is the heavy hyperphlogosis of domestic animal intestinal wall top layer and deep tissues.Domestic animal gastritis and enteritis often occur together clinically, therefore be collectively referred to as gastroenteritis.Gastroenteritis is divided into acute gastroenteritis and chronic gastroenteritis by course of disease process; Be divided into Primary Gastric enteritis and Secondary cases gastroenteritis by the cause of disease; Be divided into mucus gastroenteritis, gastroenteritis haemorrhagica, suppurative gastroenteritis and fiber disposition gastroenteritis by inflammation character.Gastroenteritis is the common frdquently encountered disease of domestic animal, especially common with horse, cattle and pig.Clinical manifestation is depressed, the inappetence of spirit, diarrhoea, dehydration, hypourocrinia.
Cause the factor of domestic animal and fowl's enteritis:
1, seasonal reason, summer, the endogenous cause of ill of poultry diarrhoea was that high temperature causes that the activity of enzyme in the poultry gastrointestinal tract is poor, caused that digestive function reduces, the intestinal burden is heavy, cause the gastrointestinal regulation function poor, immunologic function is also relatively not mature enough, so that the pathogenic microorganism amount reproduction; Exopathogenic factor is mainly that rainwater is many because temperature strengthens gradually, and the probability that therefore poultry drinks sewage is also large, so that the pathogenic microorganism amount reproduction, makes poultry more easily suffer from the fall intestinal tract disease.
2, the change of feedstuff main component (as the replacing of new Semen Maydis, add the Semen Maydis price far above Semen Tritici aestivi, therefore with Semen Tritici aestivi, replacing Semen Maydis is universal phenomenon) causes poultry pipe intestinal digesting rate low.
3, the abuse antibiotic medicine, impel gastrointestinal bacterial flora unbalance, causes the local superiority of anaerobe etc. and fall ill.
4, primary disease often and the small intestinal coccidiosis is concurrent or secondary, and very easily by the latter, covered.
5, sanitary condition is too poor is also an important reason.
6, rotavirus etc. infects the secondary antibacterial and infects.
7, feed mold.
The loss that domestic animal and fowl's enteritis causes to aquaculture:
The symptom that after poultry bacterial infection enteritis, cause vomiting, suffer from diarrhoea, the weight such as stomachache differs, cause death when serious, the morbidity growth of animals or poultry slowly even stops growing, and efficiency of feed utilization reduces, and to aquaculture, causes serious economic loss.According to conservative statistics, poultry, in the whole culture-cycle, the treatment bacterial enteritis shared ratio of medicine used accounts for more than 15% of total drug cost.Nonetheless, due to reasons such as drug resistance, bacterial enteritis remains the one of the main reasons that causes clinically the livestock and poultry cultivation failure at present.
At present, the bacterial enteritis of poultry mainly be take Western medicine as main, but, due to sustainable development and the increase of drug use time of aquaculture, drug resistance is more and more serious, due to the increase of drug resistance, the frequency of utilization of medicine and using dosage also increase gradually, more aggravated the increase of drug resistance, even indivedual places have occurred that poultry obtained situation about pasting medical help after bacterial enteritis, moreover, after these drug resistant bacterial infections people, also can cause the people to infect the situation that is difficult to treatment after drug tolerant bacteria.Due to the use of Western medicine in fowl bacterial enteritis therapeutic process, easily cause residual in livestock products of Western medicine, the people is edible to has after the livestock products of drug residue except meeting causes the generation of drug resistance, also can cause other injuries to the mankind because of the livestock products drug residue.
In view of above reason, develop a kind of efficient pure Chinese medicinal preparation, the control of the fowl bacterial enteritis frequently occurred for current cultivation has very significantly society and economic benefit.
It is raw material that the present invention adopts the Rhizoma Coptidis with heat clearing and damp drying, eliminating fire and detoxication function, and after extracting spray drying, powder adds the agent of adjuvant granulation, the diseases such as retention of damp-heat in the interior, the intestines and stomach caused for fowl bacterial enteritis is damp and hot, vomiting, dysentery.This product is pure Chinese medicinal preparation, efficient, nontoxic, noresidue, has no drug resistance, and the frequent various bacterial enteritiss that occur in intensive culture are had to good curative effect.
Conventional Chinese medicinal granule preparation method probably is divided into two kinds:
A kind of method is after medical material is extracted by suitable solvent, filter cloth or filtered through gauze, and heating is concentrated prepares extractum, and extractum adds in adjuvant and prepares granule.In the product prepared by this kind of method, impurity is many, can not be highly concentrated, and too many because of impurity such as the tannin in extractum, resins while preparing high concentration particle, need to add ethanol to assist granulation.Because the impurity hygroscopicity such as tannin, resin are strong, need the production environment of low humidity while preparing high concentration particle, ambient humidity when high concentration particle is applied packaging material, condition of storage and spice all has higher requirement.
In prior art, the preparation method of Chinese medicinal granule is that the extractum will extracted makes with extra care to remove impurity with organic solvent, although but product impurity prepared by the method is few, but subtractive process has also been removed a part of effective ingredient in medical material, has destroyed the globality of herbal medicine efficacy.
Summary of the invention
The invention provides a kind ofly for preventing and treating the Rhizoma Coptidis granule of fowl bacterial enteritis, this granule adds in drinking-water or feedstuff for poultry free choice feeding or drinking-water in the ratio of 1:500-2000, uses safety, convenient, effectively.
Rhizoma Coptidis granule provided by the invention, its 10kg prescription consists of:
Rhizoma Coptidis 1kg-10kg
Adjuvant adds to 10kg
Its preparation technology of Rhizoma Coptidis granule of the present invention realizes by following technical step:
(1) Rhizoma Coptidis of ormal weight is added to the water of 5 times of amounts, soak 2 hours, when reflux, extract, is substantially colourless to solvent color in extraction pot, collect extracting solution, when the extracting solution heating is concentrated into the solution of 3 times of amounts, concentrated solution is put 2-8 ℃ of cold preservation 24 hours, 4 layers of filtered through gauze, collect filtrate; Filtrate is that 100000 daltonian ultrafiltration posts carry out ultrafiltration with the molecular weight that dams, and fully removes the impurity such as matter, resin of mixing, and ultrafiltrate is carried out to spray drying after concentrating under reduced pressure, obtains Rhizoma Coptidis and extracts dry powder.
(2) above-mentioned Rhizoma Coptidis is extracted to dry powder and add adjuvant, by the process for producing granula granulation, obtain the Rhizoma Coptidis granule.
The invention has the beneficial effects as follows:
The present invention is directed in current aquaculture the domestic animal and fowl's enteritis sickness rate high, the Western medicine use amount is large, bacterial drug resistance is day by day serious, the livestock products drug residue brings the present situations such as harm to the mankind, selecting the efficient Rhizoma Coptidis of bacterial enteritis is principal agent, extract through decocting in water, granulate after ultra concentration and obtain the Rhizoma Coptidis granule of high concentration, the Rhizoma Coptidis granule is searched for food or drunk water for poultry through the mode of spice or drinking-water.
The present invention follows traditional boiled process, after removing impurity by ultrafiltration, fully concentrate, the globality that has retained middle the effective elements of the medicine and herbal medicine efficacy, be not subject to the restriction of ambient humidity while preparing high concentration particle and high concentration particle packaging material used, condition of storage and spice application.
The specific embodiment
The present invention can be illustrated by prescription, preparation method and the clinical result of use of following feature embodiment.
Embodiment 1: Rhizoma Coptidis granule prescription
Preparation method:
(1) Rhizoma Coptidis of ormal weight is added to the water of 5 times of amounts, soak 2 hours, when reflux, extract, is substantially colourless to solvent color in extraction pot, collect extracting solution, when the extracting solution heating is concentrated into the solution of 3 times of amounts, concentrated solution is put 2-8 ℃ of cold preservation 24 hours, 4 layers of filtered through gauze, collect filtrate; Filtrate is that 100000 daltonian ultrafiltration posts carry out ultrafiltration with the molecular weight that dams, and fully removes the impurity such as matter, resin of mixing, and ultrafiltrate is carried out to spray drying after concentrating under reduced pressure, obtains Rhizoma Coptidis and extracts dry powder.
(2) above-mentioned Rhizoma Coptidis is extracted to dry powder and add in dextrose plus saccharose, add water after fully mixing and make soft material, 16 mesh sieves are granulated, 50 ℃ of oven dry, and 14 mesh sieve granulate, obtain.
Embodiment 2: Rhizoma Coptidis granule prescription:
(1) Rhizoma Coptidis of ormal weight is added to the water of 5 times of amounts, soak 2 hours, when reflux, extract, is substantially colourless to solvent color in extraction pot, collect extracting solution, when the extracting solution heating is concentrated into the solution of 3 times of amounts, concentrated solution is put 2-8 ℃ of cold preservation 24 hours, 4 layers of filtered through gauze, collect filtrate; Filtrate is that 100000 daltonian ultrafiltration posts carry out ultrafiltration with the molecular weight that dams, and fully removes the impurity such as matter, resin of mixing, and ultrafiltrate is carried out to spray drying after concentrating under reduced pressure, obtains Rhizoma Coptidis and extracts dry powder.
(2) above-mentioned Rhizoma Coptidis is extracted to dry powder and add in glucose and lactose, add water after fully mixing and make soft material, 16 mesh sieves are granulated, 50 ℃ of oven dry, and 14 mesh sieve granulate, obtain.
Embodiment 3: Rhizoma Coptidis granule prescription:
(1) Rhizoma Coptidis of ormal weight is added to the water of 5 times of amounts, soak 2 hours, when reflux, extract, is substantially colourless to solvent color in extraction pot, collect extracting solution, when the extracting solution heating is concentrated into the solution of 3 times of amounts, concentrated solution is put 2-8 ℃ of cold preservation 24 hours, 4 layers of filtered through gauze, collect filtrate; Filtrate is that 100000 daltonian ultrafiltration posts carry out ultrafiltration with the molecular weight that dams, and fully removes the impurity such as matter, resin of mixing, and ultrafiltrate is carried out to spray drying after concentrating under reduced pressure, obtains Rhizoma Coptidis and extracts dry powder.
(2) above-mentioned Rhizoma Coptidis is extracted to dry powder and add in dextrin and lactose, add water after fully mixing and make soft material, 16 mesh sieves are granulated, 50 ℃ of oven dry, and 14 mesh sieve granulate, obtain.
Embodiment 4: Rhizoma Coptidis granule prescription:
(1) Rhizoma Coptidis of ormal weight is added to the water of 5 times of amounts, soak 2 hours, when reflux, extract, is substantially colourless to solvent color in extraction pot, collect extracting solution, when the extracting solution heating is concentrated into the solution of 3 times of amounts, concentrated solution is put 2-8 ℃ of cold preservation 24 hours, 4 layers of filtered through gauze, collect filtrate; Filtrate is that 100000 daltonian ultrafiltration posts carry out ultrafiltration with the molecular weight that dams, and fully removes the impurity such as matter, resin of mixing, and ultrafiltrate is carried out to spray drying after concentrating under reduced pressure, obtains Rhizoma Coptidis and extracts dry powder.
(2) above-mentioned Rhizoma Coptidis is extracted to dry powder and add in starch, add water after fully mixing and make soft material, 16 mesh sieves are granulated, 50 ℃ of oven dry, and 14 mesh sieve granulate, obtain.
Embodiment 5: clinical trial
1. test material
The sample of the embodiment of the present invention 2 preparations
2. method
300 of 23 age in days Luo Si 308 commercial meat birds of naturally-occurring bacterial enteritis, the tarnish of sick chicken feather, feed intake descends 20%, and jumpbogroup is suffered from diarrhoea, feces is shapeless, and indigested feedstuff is arranged in feces, in some feces, is with blood, through Disease Diagnosis of Veterinary, is bacterial enteritis.Chicken is divided into to three groups at random, and 100 every group, one group is not medication group, and one group is that one group is the Rhizoma Coptidis groups of grains by Western medicine polygynax group; The Rhizoma Coptidis granule is soluble in water in the ratio of 1:1500, for chicken, freely drink water, be used in conjunction 4 days, polygynax is soluble in water in the ratio of 1:5000, for chicken, freely drink water, be used in conjunction 4 days.
3. experimental result
Rhizoma Coptidis groups of grains medication feed intake two days later just starts to promote, and feces starts to be shaped, and than in the past, is greatly improved, be used in conjunction 4 days after feces fine, there is no indigested feces; The medication of polygynax group still has 40% chicken manure just shapeless after 4 days, indivedual chicken manures are middle band blood just; Not medication group chicken is suffered from diarrhoea and increases the weight of in four days afterwards, and 14 chickens are because of the death of dewatering.
4. interpretation of result
From result of the test, the Rhizoma Coptidis granule has good therapeutic effect to bacterial enteritis, and the polygynax element is due to drug resistance, although certain effect is arranged, effect is not remarkable, can not cure the bacterial enteritis of chicken fully.
Claims (5)
1. the preparation method of Rhizoma Coptidis granule is characterized in that its preparation process realizes in the steps below:
(1) Rhizoma Coptidis is added to the water of 5 times of amounts, soak 2 hours, when reflux, extract, is substantially colourless to solvent color in extraction pot, collect extracting solution, when the extracting solution heating is concentrated into the solution of 3 times of amounts, concentrated solution is put 2-8 ℃ of cold preservation 24 hours, 4 layers of filtered through gauze, collect filtrate; Filtrate is that 100000 daltonian ultrafiltration posts carry out ultrafiltration with the molecular weight that dams, and ultrafiltrate is carried out to spray drying after concentrating under reduced pressure, obtains Rhizoma Coptidis and extracts dry powder;
(2) above-mentioned Rhizoma Coptidis is extracted to dry powder and add adjuvant, by the process for producing granula granulation, obtain the Rhizoma Coptidis granule.
2. Rhizoma Coptidis granule according to claim 1, is characterized in that adjuvant used is selected from one or more compositionss in sucrose, dextrin, glucose, lactose, starch.
3. Rhizoma Coptidis granule as claimed in claim 1, the consumption that it is characterized in that writing out a prescription is:
Rhizoma Coptidis 1kg-10kg
Adjuvant adds to 10kg.
4. Rhizoma Coptidis granule as claimed in claim 1, is characterized in that, described Rhizoma Coptidis granule is for the control of fowl bacterial enteritis.
5. Rhizoma Coptidis granule as claimed in claim 1, is characterized in that, the using method of described Rhizoma Coptidis granule is that the Rhizoma Coptidis granule is soluble in water or admixes in animal and fowl fodder and drink or search for food for poultry.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103690625A (en) * | 2013-12-19 | 2014-04-02 | 重庆市畜牧科学院 | Traditional Chinese medicine rhizoma coptidis granules for treating damp-hot yellow and white diarrhea of piglets |
| CN103751278A (en) * | 2013-12-27 | 2014-04-30 | 湖南中医药大学 | Buddleja officinalis granules and preparation method thereof |
| CN110870888A (en) * | 2018-08-30 | 2020-03-10 | 湖北香连药业有限责任公司 | Coptis prescription granule and preparation method and application thereof |
-
2013
- 2013-07-30 CN CN2013103319688A patent/CN103417660A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103690625A (en) * | 2013-12-19 | 2014-04-02 | 重庆市畜牧科学院 | Traditional Chinese medicine rhizoma coptidis granules for treating damp-hot yellow and white diarrhea of piglets |
| CN103751278A (en) * | 2013-12-27 | 2014-04-30 | 湖南中医药大学 | Buddleja officinalis granules and preparation method thereof |
| CN110870888A (en) * | 2018-08-30 | 2020-03-10 | 湖北香连药业有限责任公司 | Coptis prescription granule and preparation method and application thereof |
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Application publication date: 20131204 |