CN102038777A - Mabaijin preparation capable of preventing and treating diarrhea of pig and production technique thereof - Google Patents
Mabaijin preparation capable of preventing and treating diarrhea of pig and production technique thereof Download PDFInfo
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Abstract
The invention relates to the fields of veterinary medicines and feed additives, in particular to a production method of Mabaijin powder and granules with special effects on preventing and treating the diarrhea disease of a pig. The method for preparing the Mabaijin powder and granules by taking four Chinese herbal medicines such as parslane herb and the like or drinking slices and the like as raw materials mainly comprises the following steps: chopping the Chinese herbal medicines such as the parslane herb and the like, and adding water for backflow extraction; obtaining a concentrated solution through concentration, membrane separation or constant pressure concentration; eliminating ineffective components in the concentrated solution through alcohol precipitation or clarification by adding a flocculating agent or membrane separation or resin absorption; concentrating, drying and crushing; adding a flavoring agent, an excipient or composite auxiliary materials; and packaging. The invention combines the advantages of a Chinese herbal medicine composition and vectors or fillings and has the advantages of experimentally optimized process, complete extraction of the effective components of the Chinese herbal medicines, simple and easy operation and easy control of the course. The prepared product has no harmful residues and is a safe green product without hormones. The invention is especially suitable for preventing and treating the diarrhea disease of the pig and simultaneously suitable for preventing and treating the animal diarrhea disease of various poultry and pets.
Description
(1) technical field
The present invention relates to the preparation method of Chinese patent medicine novel formulation, be meant that specifically a kind of is the method for feedstock production horse platinum powder and granule with four flavor Chinese medicine medical materials such as Herba Portulacae, the Radix Pulsatillae, Fructus Rosae Laevigatae, Fructus Chebulae or its decoction pieces.The present invention is specially adapted to the diarrhea of pigs prevention and treatment of diseases, also is applicable to the control of various poultry, house pet diarrhea disease simultaneously.
(2) background technology
Piglet diarrhea is a kind of common transmittable disease that is caused by pig Escherichia coli, clostridieum welchii and rotavirus, Transmissible gastroenteritis virus, epidemic diarrhea virus and bacillus perfringens etc., comprise transmissible gastroenteritis of swine, epidemic diarrhea, porcine rotavirus disease, porcine reproductive respiratory syndrome, swine fever, pseudorabies and porcine circovirus enteritis etc., have characteristics such as morbidity is anxious, propagation is fast, mortality rate height, the development of serious harm pig industry.Common piglet gastroenteropathy has piglet pujos blancos, yellow scour of piglet, baby swine paratyphoid, transmissible gastroenteritis etc.Piglet Huang, Hakuri mainly are to be caused by dust Xi Shi escherichia coli, and the piglet sickness rate of generally sucking the breast is higher, and brood piglet sickness rate can reach 80%, and wherein the mortality rate of piglet pujos blancos is lower, and the mortality rate of yellow scour of piglet is very high, sometimes even can full nest death.(EnterotoxigenicEscherichia colt ETEC) is one of the main pathogenic bacterium (Yokoyam etc., 1992) that cause newborn and diarrhea of weaned piglets to enterotoxigenic escherichia coli.The immunosuppressant that the immature and early weaning of newborn piglet and early-weaned piglets autoimmune function stress cause, be cause piglet to ETEC sensitivity increase, premunition descends, and causes the principal element of ETEC infectious diarrhea.
Chinese herbal medicine is a pure natural preparation, and toxic and side effects is little, does not have drug resistance and drug residue problem, and in addition along with the improving constantly of people's living standard, the safety of animal food more and more causes the concern of society.Chinese herbal medicine additive can also stimulate the piglet non-specific immunity when improving the piglet specific immune function.Studies show that Chinese herbal medicine additive can significantly improve protease activities in the ablactational baby pig intestinal, thereby improve the protein adsorption rate on the one hand, promote the growth promoter of histoorgan and immune organ; On the other hand, promote proteinic digesting and assimilating, the big intestinal segment microorganism of unlikely quilt excessive fermentation has prevented the diarrheal generation.
Horse platinum preparation is made up of four flavor Chinese medicines such as Herba Portulacae, the Radix Pulsatillae, Fructus Rosae Laevigatae, Fructus Chebulae, and wherein Herba Portulacae is the herb of portulacaceous plant Herba Portulacae Portulaca oleracea L..Sour in the mouth, cold in nature.Go into large intestine, liver, spleen channel.Function: heat-clearing and toxic substances removing, diffusing blood detumescence, eliminating pathogenic heat from blood to cure dysentery.Cure mainly: hematodiarrhoea pus and blood, pyretic stranguria, stranguria with blood, leukorrhagia, carbuncle malignant boil, erysipelas, scrofula.For oral administration: as to fry in shallow oil soup, 9～15g (bright product 60～120g); Or smash juice and drink.External: smash deposited, ashing and grind into powder to transfer and apply or fry in shallow oil washing.Modern times are used for the treatment of enteritis, acute arthritis, cystitis, urethritis, anusitis, bleeding hemorrhoids etc. mostly.Herba Portulacae also contains a large amount of norepinephrine and volume potassium salt except that containing multiple nutritional components such as protein, fat, sugar, crude fibre and calcium, phosphorus, ferrum.Norepinephrine energy promotes insulin secretion, regulates carbohydrate metabolism in the human body, has blood sugar lowering concentration, keeps the effect of glucostasis; Potassium salt can bring high blood pressure down, and decreased heart rate has the protection action of the heart.Herba Portulacae also contains defying age effective ingredient such as a large amount of vitamin Es, vitamin C, carotene and glutathion, and normal eating can be prevented platelet aggregation, coronary vasospasm and thrombosis, thereby prevents coronary heart disease effectively.Herba Portulacae all has strong inhibitory action to various bacteria such as dysentery bacterium, escherichia coli and staphylococcus aureuses, and the laudatory title of " natural antibiotics " is arranged.Fresh Herba Portulacae commonly used 120 grams among the people (doing 60 grams) Semen oryzae sativae 60 grams are cooked congee, or with fresh Herba Portulacae strand taking juice and heavy dose of decocting liquid, treat diseases such as damp-heat diarrhea, acute enteritis, dysentery, are the natural good medicine of heat clearing away simply, detoxifcation, antiinflammatory.So often eat health preserving benefit health in this suggestion.Herba Portulacae is hot cold can the removing heat from blood heat radiation, Gu Zhu Disorder knot, carbuncle skin ulcer furuncle is swollen, and white bald and 36 kinds of wind knot skin ulcers are smash and applied the then swollen furuncle that looses and eradicate, and strand juice clothes are then disliked thing instantly, inside and outside execute all also.Hot cold tonneau, so cold and heat go, big or small facility also.Bitter can parasite killing, cold can heat extraction, so mainly kill parasites, go to quench the thirst cun in vain; So the loose heat of lung man of Xin Hanneng is the blind nebula of argument also (" Bencao Jingshu ").The blood that looses is subsided a swelling, sharp intestinal habitual abortion, and it is treating stranguria to detoxify, the back sweating due to debility (Compendium of Material Medica) of managing property.The Radix Pulsatillae is the dry root of the cohosh Radix Pulsatillae.Spring, Qiu Erji excavate, and remove silt, drying.This product hardship, cold.Return stomach, large intestine channel.Heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery is used for toxic-heat and blood stasis, amebic dysentery.
The bright juice of the Radix Pulsatillae, decoct and ethanol extraction, experiment in vitro all has obvious inhibitory action to staphylococcus aureus, bacillus pyocyaneus, dysentery bacterium, bacillus subtilis, Bacillus typhi, Salmonella etc.The bright juice of the Radix Pulsatillae is removed after the tannin relatively poor to the effect of dysentery bacterium, and decoct is different and different according to strain concentration to the effect of dysentery bacterium; Stronger to the shigella effect; The effect of Shu Shi, Fu Shi and Song Shi bacillus is weakened or not antibacterial successively; Radix Pulsatillae alcohol extract is to tubercule bacillus unrestraint effect.The antibiotic effective ingredient of the Radix Pulsatillae is protoanemonin, Anemonin, the two all has strong activity to escherichia coli, staphylococcus aureus, dysentery bacterium, tubercule bacillus, diphtheria corynebacterium, streptococcus etc., it and have synergism with strepto-between MIC 8 * 10～2 * 10.Also reach based on the Radix Pulsatillae Decoction of the Radix Pulsatillae and respectively form medicine dysentery bacteriums such as will Hayes, Fu Shi, Amur, Song Nei Shi are all had obvious inhibitory action, do not see between the medicine that synergism is arranged but respectively form by scholar report.Antifungic action: the bacteriostatic experiment and the MIC that adopt present domestic advanced person's laboratory facilities to carry out 8 kinds of pathogenic superficial mycosiss that 10 kinds of Chinese herbal medicine such as Radix Salviae Miltiorrhizae, Radix Sophorae Flavescentis, Fructus Cnidii mainly distribute to China measure.Wherein transplant old, Rhizoma Coptidis, Rhizoma Picrorhizae, Radix Pulsatillae water extract and promptly the part superficial mycosis is produced inhibitory action in 5% concentration.The average MIC of the Radix Pulsatillae is 9.38%, and prompting can be used as the anti-superficial mycosis Chinese herbal medicine of wide spectrum.Treatment chronic diarrhea: adopt heat-clearing and toxic substances removing, invigorating the spleen to arrest diarrhea method.From quasi-solution poison spleen invigorating soup (Radix Pulsatillae, the Radix Astragali, Herba Portulacae, Radix Codonopsis, Poria, the Rhizoma Atractylodis Macrocephalae, Semen Coicis, Seem Lablab Album, the Radix Paeoniae Alba, Radix Glycyrrhizae) treatment chronic diarrhea 80 examples, total effective rate 96.25%.Adopt the acupuncture middle part of gastric cavity, Tianshu, tsu san li, sp 9 cave and connect Tonga's flavor and treat acute gastroenteritis 85 examples, cure rate 65% with the Radix Puerariae Siberian cocklebur.The prompting medicine administered by injection share have clearing away heat-damp and promoting diuresis, the effect of removing pathogenic heat from blood and toxic substance from the body, promoting the circulation of QI to relieve pain.
Fructus Rosae Laevigatae is the fruit of rosaceous plant Fructus Rosae Laevigatae Rosa laevigata Michx.Sour in the mouth, puckery, property is flat.Go into kidney, bladder, intestinal warp.Function: with smart astringing intestine to stop diarrhea, reducing urination and antidiarrheal.Cure mainly: seminal emission, the enuresis, frequent micturition, insufficiency of the spleen dysentery, the deficiency of the lung are breathed with cough, spontaneous sweating, bleeding not during menses.For oral administration: as to fry in shallow oil soup, 6～18g; Or go into ball, loose or endure cream.Bacterium effect Fructus Rosae Laevigatae contains tannin, makes bacteriostatic test with the plate method, and 25% decoct has very high bacteriostasis to staphylococcus aureus, escherichia coli, and is also effective to bacillus pyocyaneus.The Embryo Gallus domesticus evidence, the susceptible malicious PR strain inhibitory action of Fructus Rosae Laevigatae decoct convection current is very strong, and Asia first type 57-4 strain, B-mode Lee strain, 1233 strains of third type and the strain of fourth type celestial platform are also had effect.
Fructus Chebulae's sour-puckery flavor, temperature, nontoxic.Fruit contains tannin 23.60%～37.36%, and its composition is chebulinic acid, Chebulagic acid, 1,3,6～trigalloylglucose and 1,2,3,4,6～five galloyl glucoses, corilagin, terchebin, glucogallin, benzoaric acid and gallic acid etc.Contain shikimic acid, dehydroshikimis acid, quininic acid, arabinose, fructose, glucose, sucrose, rhamnose and aminoacid again.Also contain Sennoside A, terchebin, tannase, polyphenol oxidase, peroxidase, ascorbic acid oxidase etc.Bark contains β～sitosterol, tannin, benzoaric acid, gallic acid and Jiao's property catechol.The antibacterial action in vitro tests proves, and is all effective to 4～5 kinds of dysentery bacteriums, is good with Fructus Chebulae's shell especially.Fructus Chebulae's water decoction (100%) except that to various dysentery bacteriums effectively, and stronger to bacillus pyocyaneus, diphtheria corynebacterium effect, staphylococcus aureus, escherichia coli, streptococcus pneumoniae, Hemolytic streptococcus, Bacillus proteus, bacillus typhi murium also there are effect (paper disk method); Valid density to dysentery bacterium, staphylococcus aureus, bacillus pyocyaneus was respectively 1: 32, and 1: 128,1: 64 (test tube method).The Fructus Chebulae is in the external effect that good anti-Bacillus typhi is arranged, and has higher antibiotic and antifungic action with the ethanol extraction of hydrochloric acid, ether extraction.Other effects from dry fruit with 80% ethanol carry terchebin, smooth muscle is had the spasmolysis of papaverine sample; Also contain the diarrhea inducing composition except that tannin, so similar to Radix Et Rhizoma Rhei, first diarrhea inducing is then restrained.The Chinese medicine compound that contains the Fructus Chebulae had once been reported some anticancer effect.Function: astringe the lung, astringing intestine to stop diarrhea, the therapeutic method to keep the adverse QI flowing downwards is controlled chronic cough aphonia, chronic diarrhea, chronic dysentery, proctoptosis is had blood in stool.
(3) summary of the invention
The objective of the invention is to propose four flavor Chinese herbal medicine effective ingredientses such as a kind of Herba Portulacae and extract new Chinese medicine preparation and preparation method thereof completely, the diarrhea of pigs disease is had specially good effect, also be applicable to the control of animal diarrhea diseases such as pig and other poultry, house pet simultaneously.
Technology of the present invention is as follows:
The present invention is implemented by following scheme.
A kind of horse platinum powder of the present invention and process for producing granula mainly comprise following technology and step:
(1) medical material such as Herba Portulacae, the Radix Pulsatillae, Fructus Rosae Laevigatae, Fructus Chebulae or decoction pieces add water to 2～20 times of normal temperature dippings of medical material amount or heating extraction secondary or more than, the gained extracting solution merges, and filters;
(2) extracting solution concentrating under reduced pressure or membrance concentration or normal pressure are concentrated into and contain crude drug 0.1g/mL～2g/mL;
(3) concentrated solution is carried out precipitate with ethanol or adding flocculating agent clarification or membrance separation or resin absorption and remove invalid element;
(4) and then concentrate, dry, add adjuvant, granulate packing;
It can be to add ethanol to reach 40%～80% to containing the alcohol amount in concentrated solution that precipitate with ethanol in above-mentioned steps (3) is removed invalid element, leaves standstill or cold preservation, removes insoluble matter and gets clear liquor.
It can be to add chitosan, various clarifier flocculation back disgorging in concentrated solution that invalid element is removed in flocculation in above-mentioned steps (3), makes clear and bright liquid.
It can be that concentrated solution is passed through macroporous resin column that resin absorption in above-mentioned steps (3) is removed invalid element, and effective ingredient is adsorbed, and the ethanol elution with 50% to 95% is collected eluent and got final product:
Horse platinum in above-mentioned steps (1) can be medical material or decoction pieces, and normal temperature dipping extraction time can be 3～24h, adds the time of getting can be 0.5～5h.
Adjuvant in the above-mentioned steps (4) is correctives, excipient or its combination.Concentrate at step (4) herb liquid, to be refined liquid be concentrated into thick paste or the thousands of extractum of the further drying under reduced pressure of thick paste or thick paste by concentrating under reduced pressure or membrance concentration or normal pressure to drying is spray dried to dry powder, can be made into horse platinum powder.
Correctives in the step (3) is the combination of sweetener, aspartame, steviol glycosides, xylitol or above-mentioned several correctivess;
Excipient in the step (3) is starch, polyvinylpyrrolidone, beta-schardinger dextrin-, dextrin, sodium carboxymethyl cellulose, low-substituted hydroxypropyl cellulose.
Various technology modes in horse platinum powder of the present invention and granule raw material composition and the preparation process thereof are through repeatedly experimentation is preferred, have that Chinese herbal medicine active ingredient such as horse platinum is extracted fully, loss of effective components is little, simple, be easy to control, yield and quality is stable, the characteristics of no hazard residue.Finished product of the present invention is a kind of novel antibiotic succedaneum, has antibiotic, the immunologic function of enhancing body, can suppress pathogenic diarrhea of pigs growth of pathogenic bacteria, and vast market prospect is arranged.
(4) specific embodiment
The specific embodiment one:
Get Herba Portulacae, the Radix Pulsatillae, Fructus Rosae Laevigatae, Fructus Chebulae's medical material 500g, with its chopping, add the water reflux, extract, 2 times, add for the first time 8 times of water gagings, add 6 times of water gagings, each 1h of extraction time for the second time, again the gained extracting solution is merged, filters, extracting solution is evaporated to 500mL, and contain crude drug amount in the concentrated solution this moment is 1.0g/mL, adds ethanol then, make and contain alcohol amount in the concentrated solution and reach 65%, leave standstill 24h, filter the filtrate decompression reconcentration, be dried to thick paste, add cane sugar powder again, dry, pulverizing, packing promptly gets horse platinum powder.
The specific embodiment two: get Herba Portulacae, the Radix Pulsatillae, Fructus Rosae Laevigatae, Fructus Chebulae's decoction pieces 1000g, decoct with water 3 times, decoct 5h, 3h, 2h respectively at every turn, the gained extracting solution is merged, filters, normal pressure is concentrated into 2000mL again, contain crude drug amount in the concentrated solution this moment is 2.0g/mL, add chitin solution then, leaving standstill 12h filters, filtrate decompression reconcentration, drying under reduced pressure get dry extract, add starch, sodium carboxymethyl cellulose adjuvant again, make granule by dry granulation, packing promptly gets horse platinum granule.
The specific embodiment three: get Herba Portulacae, the Radix Pulsatillae, Fructus Rosae Laevigatae, Fructus Chebulae's medical material L00kg, decoct with water 5 times, decoct 2h respectively at every turn, 2h, 1h, 1h, 1h, the gained extracting solution is merged, filter, normal pressure is concentrated into 1000L again, contain crude drug amount in the concentrated solution this moment is 1.5g/mL, concentrated solution passes through macroporous resin column, ethanol elution with 50～90% is collected eluent, and eluent decompression reconcentration is to thick paste, the thousands of powder of spray drying, add dextrin again, the low-substituted hydroxypropyl cellulose adjuvant makes the granule that every gram granule is equivalent to the 12g raw medicinal herbs by dry granulation, and packing promptly gets horse platinum granule at last.
The specific embodiment four: get Herba Portulacae, the Radix Pulsatillae, Fructus Rosae Laevigatae, Fructus Chebulae's medical material 500g, decoct with water 3 times, decoct 2h, 2h, 1h at every turn respectively, filtration or direct normal pressure are concentrated into 250mL behind the merge extractive liquid,, concentrated solution adds ethanol, makes to contain the alcohol amount and reach 82%; Cold preservation 24h filters, and filtrate decompression reconcentration, drying under reduced pressure get dry extract, by dry, pulverizing, packing, promptly gets horse platinum powder.
The specific embodiment five: get Herba Portulacae, the Radix Pulsatillae, Fructus Rosae Laevigatae, Fructus Chebulae's medical material 500g, decoct with water 2 times, decoct 1h respectively, behind the merge extractive liquid, at every turn, filter, adopt membrance concentration to 400mL again, concentrated solution is collected effective ingredient by 200 molecular weight membrane separation plants, collect liquid decompression reconcentration to thick paste, add polyvinylpyrrolidone, beta-schardinger dextrin-, lactose, sodium carboxymethyl cellulose adjuvant, make granule by wet granulation, drying, packing promptly gets horse platinum granule.
The specific embodiment six: get Herba Portulacae, the Radix Pulsatillae, Fructus Rosae Laevigatae, Fructus Chebulae's medical material 1500g, decoct with water 3 times, decoct 2h, 2h, 1h respectively at every turn, the gained extracting solution is merged, filters, be evaporated to clear paste, spraying drying powder-forming directly makes granule by dry granulation, and packing promptly gets horse platinum granule.
The specific embodiment seven: get Herba Portulacae, the Radix Pulsatillae, Fructus Rosae Laevigatae, Fructus Chebulae's medical material 500g, decoct with water 2 times, decoct 1h at every turn respectively, the gained extracting solution is merged, filters, adopt membrance concentration to 400mL again, concentrated solution is used 58% ethanol elution by macroporous resin column, collects eluent, eluent concentrating under reduced pressure, drying under reduced pressure get dry extract, add starch, polyvinylpyrrolidone adjuvant again, make granule by dry granulation, packing promptly gets horse platinum granule.。
The specific embodiment eight: get Herba Portulacae, the Radix Pulsatillae, Fructus Rosae Laevigatae, Fructus Chebulae's medical material 200kg, decoct with water 2 times, decoct 2h, Lh at every turn respectively, the gained extracting solution is merged, filters, be evaporated to 200L, Cryoprecipitation 24h.High speed centrifugation or filter press, filtrate decompression reconcentration, drying under reduced pressure get dry extract, add cane sugar powder, beta-schardinger dextrin-, starch supplementary material again, make granule by dry granulation, and packing promptly gets horse platinum granule.
The specific embodiment nine: get Herba Portulacae, the Radix Pulsatillae, Fructus Rosae Laevigatae, Fructus Chebulae's medical material 500g, add water retting 3 times, flood 12h, 10h, 5h at every turn respectively, the gained extracting solution is merged, filters, again extracting solution is evaporated to 250mL, concentrated solution adds ethanol, makes to contain the alcohol amount and reach 56%, cold preservation 24h, filter, filtrate decompression concentrates, drying under reduced pressure gets dry extract, directly makes granule by dry granulation, and packing promptly gets horse platinum granule.
Claims (6)
1. a horse platinum powder and the process for producing granula that can prevent and treat diarrhea of pigs, it is characterized in that comprising following technology and step: get medical materials such as Herba Portulacae, the Radix Pulsatillae, Fructus Rosae Laevigatae, Fructus Chebulae or decoction pieces and add water, normal temperature dipping or heating extraction secondary or more than, the gained extracting solution merges, and filters; Extracting solution concentrating under reduced pressure or membrance concentration or normal pressure are concentrated; And then concentrate, spray drying, pulverizing, add carrier or adjuvant, packing.
2. horse platinum powder as claimed in claim 1 and process for producing granula is characterized in that: utilize ultrafiltration to remove excess moisture, add ethanol in concentrated solution, leave standstill or cold preservation, remove insoluble matter and must clarify medicinal liquid.
3. horse platinum powder as claimed in claim 1 and process for producing granula is characterized in that: add chitosan, clarifier in concentrated solution, flocculation back disgorging makes clear and bright liquid.
4. horse platinum powder as claimed in claim 1 and process for producing granula is characterized in that: the adjuvant of adding is correctives, excipient or its combination; Correctives is sweetener, aspartame, steviol glycosides, xylitol, or the combination of above-mentioned several correctivess; Excipient is starch, polyvinylpyrrolidone, beta-schardinger dextrin-, dextrin, sodium carboxymethyl cellulose.
5. horse platinum powder as claimed in claim 1 and process for producing granula is characterized in that: concentrated solution is concentrated into thick paste by decompression, membrane filtration or normal pressure, is spray dried to dry powder through drying under reduced pressure or thick paste.
6. the Ma Baijinke that can prevent and treat livestock and birds respiratory disease according to claim 1 breathes heavily preparation and production technology, it is characterized in that: adopt oral, method administration such as companion's material etc., livestock and birds respiratory disease there is specially good effect, also is used for the control of animal breath tract diseases such as various house pets.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102302778A (en) * | 2011-09-26 | 2012-01-04 | 方希修 | Preparation method and application of traditional Chinese medicinal immunoglobulin compound preparation |
| CN102670780A (en) * | 2012-06-08 | 2012-09-19 | 徐州金牌药业有限公司 | Antidysenteric for livestock and poultry and preparation method thereof |
| CN103330092A (en) * | 2013-07-17 | 2013-10-02 | 徐州联益生物科技开发有限公司 | Antidiarrheal pet food |
| CN103860714A (en) * | 2013-05-07 | 2014-06-18 | 武汉市畜牧兽医科学研究所 | Compound traditional Chinese medicine extract for preventing and treating livestock diarrhea syndrome and application thereof |
| CN115778991A (en) * | 2022-11-16 | 2023-03-14 | 广东医科大学 | Application of myrobalan tannic acid in preparation of anti-rotavirus drugs |
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2009
- 2009-10-20 CN CN2009102082236A patent/CN102038777A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102302778A (en) * | 2011-09-26 | 2012-01-04 | 方希修 | Preparation method and application of traditional Chinese medicinal immunoglobulin compound preparation |
| CN102670780A (en) * | 2012-06-08 | 2012-09-19 | 徐州金牌药业有限公司 | Antidysenteric for livestock and poultry and preparation method thereof |
| CN103860714A (en) * | 2013-05-07 | 2014-06-18 | 武汉市畜牧兽医科学研究所 | Compound traditional Chinese medicine extract for preventing and treating livestock diarrhea syndrome and application thereof |
| CN103860714B (en) * | 2013-05-07 | 2016-04-20 | 武汉市畜牧兽医科学研究所 | A kind of compound Chinese medicine extract and application thereof preventing and treating livestock and poultry diarrhea syndrome |
| CN103330092A (en) * | 2013-07-17 | 2013-10-02 | 徐州联益生物科技开发有限公司 | Antidiarrheal pet food |
| CN115778991A (en) * | 2022-11-16 | 2023-03-14 | 广东医科大学 | Application of myrobalan tannic acid in preparation of anti-rotavirus drugs |
| CN115778991B (en) * | 2022-11-16 | 2023-09-15 | 广东医科大学 | Application of myrobalan Lin Rousuan in preparation of rotavirus resistant medicines |
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Assignee: Xuzhou Jinpai Pharmaceutical Co., Ltd. Assignor: Wang Shouxuan|Wang Dongmei|Fang Xixiu Contract record no.: 2012320000054 Denomination of invention: Mabaijin preparation capable of preventing and treating diarrhea of pig and production technique thereof License type: Exclusive License Open date: 20110504 Record date: 20120208 |
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Application publication date: 20110504 |