CN104873798B - A kind of composition for improving immunity of livestock - Google Patents
A kind of composition for improving immunity of livestock Download PDFInfo
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- CN104873798B CN104873798B CN201510103193.8A CN201510103193A CN104873798B CN 104873798 B CN104873798 B CN 104873798B CN 201510103193 A CN201510103193 A CN 201510103193A CN 104873798 B CN104873798 B CN 104873798B
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production
Abstract
The present invention relates to Chinese veterinarian's medicine field, more particularly to a kind of composition for improving immunity of livestock, its combination has three kinds, basis combination is root of phragmites communis, sweet wormwood, the root bark of white mulberry, cape jasmine, the component of the first modified combination is root of phragmites communis, sweet wormwood, the root bark of white mulberry, cape jasmine, dregs of beans, vinegar grain, honeysuckle, radix scutellariae, Fructus Forsythiae, and the component of second of modified combination is root of phragmites communis, sweet wormwood, the root bark of white mulberry, cape jasmine, dregs of beans, vinegar grain, rhizoma cyperi, fructus amomi, Pogostemon cablin, Poria cocos, Cortex Magnoliae Officinalis, the tuber of pinellia, Rhizoma Atractylodis Macrocephalae, the dried immature fruit of citron orange, radix glycyrrhizae, Amomum cardamomum, dried orange peel, the banksia rose, jujube, ginger.The product of the present invention can improve the immunity of livestock and poultry, the activity of digestive ferment, improve the growth of livestock and poultry, reduce aquaculture cost, have good Social benefit and economic benefit.
Description
Technical field
The present invention relates to Chinese veterinarian's medicine field, and in particular to a kind of composition for improving immunity of livestock.
Background technology
On 2 24th, 2014, State Statistics Bureau announced " national economy and social development statistical communique in 2013 ", 2013
Annual 85360000 tons of meat total output, increases by 1.8% than last year.Wherein, 54,930,000 tons of pork yield, increase by 2.8%；Beef produces
6,730,000 tons are measured, increases by 1.7%；4,080,000 tons of Mutton yield, increases by 1.8%；17,980,000 tons of poultry yield, declines 1.3%.Year end
Live pig livestock on hand 474,110,000, declines 0.4%；Live pig delivers 715,570,000 for sale, increases by 2.5%.28,760,000 tons of birds, beasts and eggs yield, increases
0.5%.35,310,000 tons of milk crop, declines 5.7%.
Obviously, livestock and poultry cultivation is the advantage in China's traditional agriculture in occupation of important proportion in China's agricultural economy
Industry.Livestock and poultry cultivation is the source of finance of raiser, is related to the sound development of Chinese society.
Grain about 350kg need to be consumed by one market pig of production to calculate, whole year consumption feed grain is up to 2.135 hundred million tons.Can
It is that, as corn, the dregs of beans of live pig production main foundation daily ration, 70% leans on import.Therefore, feed price is of flowing rhythm, leads
Many raisers are caused to be absorbed in depth loss.
The scale of China's pig breeding industry, standardization level are low, and the overwhelming majority is with single household and dispersion raising or small rule
Based on mould raising.Current distinct issues be breeding facility is simple and crude, breeding environment is severe, feeding management is extensive, stocking density is big,
Epidemic prevention condition is poor, disinfection is not caught up with, and various pathogenic microorganisms are easily propagated in external environment, causes the frequent hair of swine disease
It is raw.The distance between the distance between small-scale pig farm, small-scale pig farm and decentralized household are relatively near, and cultivation is in dirty, poor environment
Among, cause the pathogenic microorganism cyclicity on the scene between field, between field and family and lasting contact scar.This is pig in recent years
The main factor that field epidemic disease is difficult to control.
《China's pig-breeding regional distribution change trend》One text is each by analyzing 1981-2011 years 30 Nian Lai China
The statistics such as the pig-breeding amount of provinces and regions and corn yield, discloses 30 Nian Jian China pig-breeding regional distribution change trend.
Analysis finds that live pig production area is gradually concentrated to major grain producing area, and the superiority of middle part starts to highlight, southwest, China
The status of eastern pig-breeding Predominance Area is gradually reduced, and live pig the deliver amount regional to Central China in 2011, southwest, 3, East China is almost
Maintain an equal level, account for the 69.6% of the national always amount of delivering for sale altogether.The superiority of prediction Central China may proceed to raise, North China, northeast live pig
The amount of delivering for sale may proceed to increase, and the ratio regular meeting that southwest, East China, south China live pig account for the total amount of delivering for sale in the whole nation is gradually reduced.
Some recent raisers to reduce aquaculture cost, examination using herbage, peanut vine, etc. substitute corn, bean-dregs feed grain,
Or be added in feed, the feeding cost of livestock and poultry is reduced, this not only allows raiser to realize in the same old way under sluggish market to be full of
Profit.
But the problems such as clenbuterol hydrochloride due to continuously occurring, Escherichia coli, streptococcus, residue of veterinary drug, vaccine virulence residual
Seriously affected China's food-safety problem, also seriously affected the sound development of aquaculture industry of China, reduce antibiotic, vaccine,
The use of artificial synthesized medicine is a big measure of current healthy aquaculture, and herbage, peanut vine can be used as Chinese medicine on the other hand
To use, this also complies with the social desirability for improving meat food safety.
At present, Chinese medicine and its extract are applied to animal productiong to improve breeding performonce fo animals, immune performance and improvement
Meat Quality Research causes the concern of medicine and animal nutrition researcher.Chinese patent drug is as a kind of new feed addition
Agent, health care medicinal gradually become aquaculture and are received.Developing the fodder compound of herbal medicine has extensive market prospects and social valency
Value.
The content of the invention
The technical problem to be solved in the present invention is to provide a kind of composition that can improve immunity of livestock.
In order to solve the above technical problems, the technical solution used in the present invention is as follows.
A kind of composition for improving immunity of livestock, its constituent is 1-10 grams of root of phragmites communis, 20-60 grams of sweet wormwood, Sang Bai
10-20 grams of skin, 10-20 grams of cape jasmine, 4000-10000 grams of dregs of beans.
A kind of composition for improving immunity of livestock, its constituent is 1-10 grams of root of phragmites communis, 20-60 grams of sweet wormwood, Sang Bai
10-20 grams of skin, 10-20 grams of cape jasmine, 4000-10000 grams of dregs of beans, 20-60 grams of vinegar grain.
As a preferred technical solution of the present invention, its constituent is 1-10 grams of root of phragmites communis, 20-60 grams of sweet wormwood, mulberry
White 10-20 grams of skin, 10-20 grams of cape jasmine, 4000-10000 grams of dregs of beans, 20-60 grams of vinegar grain, the medicinal material residue 100- of Chinese patent drug
1000 grams.
As a preferred technical solution of the present invention, following component is included in the medicinal material residue of the Chinese patent drug：Gold
Honeysuckle flower, radix scutellariae, Fructus Forsythiae.
As a preferred technical solution of the present invention, following component is included in the medicinal material residue of the Chinese patent drug：It is fragrant
Attached, fructus amomi, Pogostemon cablin, Poria cocos, Cortex Magnoliae Officinalis, the tuber of pinellia, Rhizoma Atractylodis Macrocephalae, the dried immature fruit of citron orange, radix glycyrrhizae, Amomum cardamomum, dried orange peel, the banksia rose, jujube, ginger.
A kind of composition for improving immunity of livestock, it is characterized in that：Its constituent is 1-10 grams of root of phragmites communis, sweet wormwood 20-
60 grams, 10-20 grams of the root bark of white mulberry, 10-20 grams of cape jasmine, 4000-10000 grams of corn flour.
As a preferred technical solution of the present invention, its constituent is 1-10 grams of root of phragmites communis, 20-60 grams of sweet wormwood, mulberry
White 10-20 grams of skin, 10-20 grams of cape jasmine, 4000-10000 grams of corn flour, 20-60 grams of vinegar grain.
As a preferred technical solution of the present invention, its constituent is 1-10 grams of root of phragmites communis, 20-60 grams of sweet wormwood, mulberry
White 10-20 grams of skin, 10-20 grams of cape jasmine, 4000-10000 grams of corn flour, 20-60 grams of vinegar grain, the medicinal material residue 100- of Chinese patent drug
1000 grams.
As a preferred technical solution of the present invention, following component is included in the medicinal material residue of the Chinese patent drug：Gold
Honeysuckle flower, radix scutellariae, Fructus Forsythiae.
As a preferred technical solution of the present invention, following component is included in the medicinal material residue of the Chinese patent drug：It is fragrant
Attached, fructus amomi, Pogostemon cablin, Poria cocos, Cortex Magnoliae Officinalis, the tuber of pinellia, Rhizoma Atractylodis Macrocephalae, the dried immature fruit of citron orange, radix glycyrrhizae, Amomum cardamomum, dried orange peel, the banksia rose, jujube, ginger.
The livestock and poultry of the present invention include the animals such as pig, chicken.The present invention can be used for prepare animal drugs, health care medicinal, animal nutrition,
Feed addictive；Its formulation is pulvis, powder, granule, capsule, tablet, oral liquid, feed addictive, fodder compound.
The Chinese patent drug involved by Chinese patent drug medicinal material residue that the present invention uses is：Shuanghuanglian oral liquid, cyperus-amomum stomach mouth
Take liquid.
Wherein, Shuanghuanglian oral liquid according to《Chinese Pharmacopoeia in 2005, Shuanghuanglian oral liquid》Standard prepare.
【Prescription】Honeysuckle 375g, radix scutellariae 375g, Fructus Forsythiae 750g
【Preparation method】Three taste of the above, radix scutellariae add water to cook three times, for the first time 2 it is small when, second and third time it is each 1 it is small when, merge decoct
Liquid, filtration, filtrate concentration simultaneously adds 2mol/L hydrochloric acid solutions at 80 DEG C and adjusts pH value in right amount to 1.0~2.0, when insulation 1 is small,
Stand 12 it is small when, filtration, precipitation plus 6~8 times amount water, with 40% sodium hydroxide solution adjust pH value to 7.0, then add equivalent second
Alcohol, is stirred to dissolve, filtration, and filtrate adjusts pH value with 2mol/L hydrochloric acid solutions and keeps the temperature 30 minutes to 2.0,60 DEG C, stands 12 small
When, filtration, it is 7.0 that precipitation is washed till pH value with ethanol, and recycling ethanol is spare；After honeysuckle, Fructus Forsythiae add water temperature to soak 30 minutes, decoct
It is secondary, every time 1.5 it is small when, collecting decoction, filtration, it is clear for 1.20~1.25 (70~80 DEG C) that filtrate is concentrated into relative density
Cream, ethanol is slowly added into when being cooled to 40 DEG C, alcohol content is sufficiently stirred up to 75%, stand 12 it is small when, leaching supernatant, residue
Add 75% appropriate amount of ethanol, stir evenly, when standing 12 is small, filtration merges ethanol, and recycling ethanol adds above-mentioned radix scutellariae to no alcohol taste
Extract, and add appropriate amount of water, pH value is adjusted to 7.0 with 40% sodium hydroxide solution, stirs evenly, when refrigeration (4~8 DEG C) 72 are small, filters
To cross, filtrate adds sucrose 300g, is stirred to dissolve, and it is appropriate and adjust pH value to 7.0 to add essence, adds water that 1000ml is made,
Stir evenly, when standing 12 is small, filtration is filling, sterilizing, to obtain the final product.
The medicinal material residue of Shuanghuanglian oral liquid is obtained, wherein containing radix scutellariae medicinal materials residue, traditional Chinese medicine honeysuckle residue,
Fructus Forsythiae medicinal material residue.
Wherein, cyperus-amomum stomach oral liquid according to《The authentication codes of WS3-B-3941-98》Prepared：
【Prescription】Rhizoma cyperi (vinegar system) 100g, fructus amomi 100g, Pogostemon cablin 100g, Poria cocos 100g, Cortex Magnoliae Officinalis (ginger system) 100g, the tuber of pinellia
(system) 100g, Rhizoma Atractylodis Macrocephalae (bran stir-fry) 100g, the dried immature fruit of citron orange (bran stir-fry) 100g, radix glycyrrhizae 50g, Amomum cardamomum (are shelled) 50g, dried orange peel 50g, the banksia rose
50g, jujube 40g, ginger (smash) 10g to pieces.
【Preparation method】14 taste of the above, takes rhizoma cyperi, Cortex Magnoliae Officinalis, Rhizoma Atractylodis Macrocephalae, the dried immature fruit of citron orange, dried orange peel, according under liquid extract and extract item
Percolation (annex I O), with 60% ethanol as solvent, when dipping 24 is small, slowly diacolation, it is about the 10 of crude drug amount to collect percolate
Times, liquid of filtering is spare.It is another to take Pogostemon cablin, fructus amomi, Amomum cardamomum, the banksia rose, ginger extraction volatile oil, the dregs of a decoction and Poria cocos, the tuber of pinellia, jujube,
Radix glycyrrhizae add water to cook it is secondary, every time 2 it is small when, filtration, filtrate cooling after add in above-mentioned liquid of filtering, stand 24 it is small when, filtration, filtrate
Ethanol is recycled, is concentrated into right amount, cane sugar powder 200g, preservative and above-mentioned volatile oil is added after cooling, about 1000ml is made, i.e.,
.
The medicinal material residue of cyperus-amomum stomach oral liquid is obtained, wherein containing rhizoma cyperi (vinegar system) medicinal material residue, fructus amomi medicinal material
Residue, Pogostemon cablin medicinal material residue, Poria cocos medicinal material residue, Cortex Magnoliae Officinalis (ginger system) medicinal material residue, the tuber of pinellia (system) medicinal material are remaining
Thing, Rhizoma Atractylodis Macrocephalae (bran stir-fry) medicinal material residue, the dried immature fruit of citron orange (bran stir-fry) medicinal material residue, licorice medicinal materials residue, Amomum cardamomum (are shelled) medicinal material
Residue, dried orange peel medicinal material residue, banksia rose medicinal material residue, jujube medicinal material residue, ginger (smash) medicinal material residue to pieces.
One of preparation method of the present invention is：
Take 1-10 grams of root of phragmites communis, 20-60 grams of sweet wormwood, 10-20 grams of the root bark of white mulberry, 10-20 grams of cape jasmine, dregs of beans 4000-10000
Gram.
Chinese medicine is mixed, is crushed, adds 10-30 times of water, is decocted 2-4 times, each 30-60min, filtration, liquid is concentrated to
Relative density is 1.10-1.20g/ml, is admixed in dregs of beans, after exhaustion, is covered with the Chinese medicine residue decocted, between two layers
Isolated with gauze, in 25-35 DEG C of closed culture 2-5 days, ferment on yellow clothes all over when, take out, the removing dregs of a decoction, slightly dry in the air, put 25-35
Closed culture 10-30 days in DEG C, when being overflowed to abundant fermentation, fragrance, take out, dry, to obtain the final product.
The preparation method of the present invention two is：
Take 1-10 grams of root of phragmites communis, 20-60 grams of sweet wormwood, 10-20 grams of the root bark of white mulberry, 10-20 grams of cape jasmine, corn flour 4000-10000
Gram.
Chinese medicine is mixed, is crushed, adds 10-30 times of water, is decocted 2-4 times, each 30-60min, filtration, liquid is concentrated to
Relative density is 1.10-1.20g/ml, is admixed in corn flour, after exhaustion, is covered with the Chinese medicine residue decocted, two layers it
Between isolated with gauze, in 25-35 DEG C of closed culture 2-5 days, ferment on yellow clothes all over when, take out, the removing dregs of a decoction, slightly dry in the air, put 25-
Closed culture 10-30 days in 35 DEG C, when being overflowed to abundant fermentation, fragrance, take out, dry, to obtain the final product.
The preparation method of the present invention three is：
Take 1-10 grams of root of phragmites communis, 20-60 grams of sweet wormwood, 10-20 grams of the root bark of white mulberry, 10-20 grams of cape jasmine, dregs of beans 4000-10000
Gram, 20-60 grams of vinegar grain.
Chinese medicine is mixed, is crushed, adds 10-30 times of water, is decocted 2-4 times, each 30-60min, filtration, liquid is concentrated to
Relative density is 1.10-1.20g/ml, is admixed in dregs of beans, vinegar grain, after exhaustion, is covered with the Chinese medicine residue decocted, two layers
Between isolated with gauze, in 25-35 DEG C of closed culture 2-5 days, ferment on yellow clothes all over when, take out, the removing dregs of a decoction, slightly dry in the air, put
Closed culture 10-30 days in 25-35 DEG C, when being overflowed to abundant fermentation, fragrance, take out, dry, to obtain the final product.
The preparation method of the present invention four is：
Take 1-10 grams of root of phragmites communis, 20-60 grams of sweet wormwood, 10-20 grams of the root bark of white mulberry, 10-20 grams of cape jasmine, corn flour 4000-10000
Gram, 20-60 grams of vinegar grain, mixes Chinese medicine, crushes, and adds 10-30 times of water, decocts 2-4 times, each 30-60min, filtration, liquid
It is 1.10-1.20g/ml to be concentrated to relative density, is admixed in corn flour, vinegar grain, after exhaustion, with the Chinese medicine residue decocted
Covering, is isolated with gauze between two layers, in 25-35 DEG C of closed culture 2-5 days, ferment on yellow clothes all over when, take out, removing medicine
Slag, slightly dries in the air, and puts closed culture 10-30 days in 25-35 DEG C, when being overflowed to abundant fermentation, fragrance, takes out, dry, to obtain the final product.
The preparation method of the present invention five is：
Take the medicinal material of 1-10 grams of root of phragmites communis, 20-60 grams of sweet wormwood, 10-20 grams of the root bark of white mulberry, 10-20 grams of cape jasmine, Chinese patent drug remaining
400-1000 grams of thing, 4000-10000 grams of dregs of beans, 20-60 grams of vinegar grain.
Chinese medicine is mixed, is crushed, adds 10-30 times of water, is decocted 2-4 times, each 30-60min, filtration, liquid is concentrated to
Relative density is 1.10-1.20g/ml, admix in dregs of beans, vinegar grain, after exhaustion, with Chinese medicine residue, the Chinese patent drug decocted
The covering of 100-500 grams of medicinal material residue, is isolated with gauze between two layers, in 25-35 DEG C of closed culture 2-5 days, is fermented to yellow clothes
It is upper all over when, take out, remove the dregs of a decoction, slightly dry in the air, put closed culture 10-30 days in 25-35 DEG C, during to abundant fermentation, fragrance spilling, take
Go out, it is dry, to obtain the final product.
The preparation method of the present invention six is：
Take the medicinal material of 1-10 grams of root of phragmites communis, 20-60 grams of sweet wormwood, 10-20 grams of the root bark of white mulberry, 10-20 grams of cape jasmine, Chinese patent drug remaining
400-1000 grams of thing, 4000-10000 grams of corn flour, 20-60 grams of vinegar grain, mixes Chinese medicine, crushes, and adds 10-30 times of water, decocts
Boil 2-4 times, each 30-60min, filter, it is 1.10-1.20g/ml that liquid, which is concentrated to relative density, admixes corn flour, vinegar grain
In, it is closed at 25-35 DEG C with 100-1000 grams of covering of Chinese medicine residue, the medicinal material residue of Chinese patent drug decocted after exhaustion
Culture 2-5 days, ferment on yellow clothes all over when, take out, remove the dregs of a decoction, slightly dry in the air, put it is closed in 25-35 DEG C cultivate 10-30 days, to filling
When distributing ferment, fragrance spilling, take out, it is dry, to obtain the final product.
It is using beneficial effect caused by above-mentioned technical proposal：The preferred formula of the present invention and its dosage are (in and
Medicine fermentation preparation process), the immunity and constitution of livestock and poultry are improved from the heart, liver, lung opinion, has been finally reached unexpected effect.
The specificity and nospecific immunity of the composition enhancing body of the present invention, increase the generation of antibody and complement, increase cell because
The generation of son, suppresses virus breeding (expression for suppressing virus mRNA in vivo), removes harmful free radicals, and antibacterial, eliminate complication,
Kidney is protected in liver protection, so as to ensure normal physiological function and eliminate pathogenic factor.The prescription of the present invention is to bacteriogenic endotoxin
There is neutralization destruction with exotoxin, the defense function of body can be strengthened, strengthen the phagocytosis of cell, promote lymphocyte
Conversion ratio, so as to improve the resistance infection of body, while helps to improve digestive function, promotes appetite, strengthen immunity.
The present invention, using dregs of beans, the fermentation coordinating the drug actions of a prescription of corn flour, is relaxed using dregs of beans, the method for fermentation of corn starch
The disadvantage in Chinese medicine big bitter Great Cold, while remove the bitter substance in dregs of beans, corn flour, improve the palatability of the present invention.The present invention is also
The method fermented using the medicinal material residue of dregs of beans, corn flour, vinegar grain and Chinese patent drug, is improved using the medicinal material residue of Chinese patent drug
The drug effect of the present invention；Shuanghuanglian oral liquid, expelling wind to resolve the exterior is clearing heat and detoxicating, for the flu caused by affection of exogenous wind-heat, symptoms include generate heat,
Cough, pharyngalgia；Cyperus-amomum stomach oral liquid, warming middle-JIAO for easing the stomach, for do not feel like eating, the full vexed or general acid regurgitation water of gastral cavilty.
For animal nutrition, mixed feed that livestock and poultry mainly search for food based on plant feed, plant feed
Cell membrane is formed by anti-nutritional factors non-starch polysaccharide (NSP).These NSP not only hinder in animal alimentary canal endogenous enzymes with
Cellular content coming into full contact with and mixing in plant feed, and itself is not easy to be digested and assimilated by animal.A part
Mono- glucan of soluble non-starch polysaccharide such as araboxylan and β, formation viscous gum matter makes chyme in animal intestinal tract
Viscosity increase, so as to reduce the interaction of nutrient and endogenous enzymes, the digestion rate of nutrient slows down, and causes disappearing for nutriment
Rate reduces and absorptivity declines, and non-starch polysaccharide can also suppress enteron aisle enzyme activity.The addition of Chinese herbal medicine fermentate of the present invention, changes
The physical and chemical composition of chyme, reduces the effect of anti-nutritional factors, reduces the adhesion on fine hair to a certain extent in small intestine,
The efficiency of digesting and assimilating of nutrient in daily ration is improved, it is cost-effective so as to reduce the dosage of daily ration, improve benefit.The present invention
The addition of Chinese herbal medicine fermentate is remarkably improved grower pigs intestinal protease, lipase and part glycometabolism enzyme and cellulase
Activity.The present invention is not the mixture of simple Chinese herbal medicine, nor active bacteria formulation, but with the compound preparation group of elaborate combination
Compatibility is closed, can effectively lift the immunity of livestock and poultry.
The effect of the raw materials used component of the present invention is described below：
Root of phragmites communis is the common herbal variety in China, is representative herbal medicine that is clearing heat and detoxicating, slaking thirst and help produce saliva, and be easy to plant
Plant and cultivate, is cheap, be common among prescription.《Records of Tradition Chinese and Western Medicine in Combination》In refer to root of phragmites communis " and its it is cool in nature can clearing lung-heat heat,
Hollow to manage lung qi, and more liquid sweet in flavor, kind nourishing lung yin, then it is bright to be better than stem in fact with root "；《Compendium of Materia Medica》Say reed root
" entering lung, stomach, bladder warp ", illustrates that the primary efficacy of root of phragmites communis is to remove lung heat lung carbuncle.Modern pharmacology research shows, reed
Contain Coixol, free dried meat amino acid, asparagine and flavone compound Tricin, forulic acid isoreactivity component in root.
Sweet wormwood (Artemisia carvifolia), is feverfew deficient heat clearing drug.《Compendium of Materia Medica》:" preventing and curing malaria disease fever and chills.
Sweet wormwood bitter, micro-pungent, cold in nature, Return liver, courage, kidney channel, fragrance is cool, thoroughly interior inside and outside, has clearing deficient heat, clear heat preventing malaria, dehumidifying
The effect of desinsection, cure mainly deficiency of Yin hectic fever hectic fever due to yin, outer temperature-sensing thermal summer-heat and damp, and the head swoons, malaria, jaundice, rush down dysentery, mange, skin scabies
Itch.
The root bark of white mulberry is moraceae plants mulberry (Classification system：Morus alba L.) dry root skin.Alias Cortex Mori, mulberry
Root skin, mulberry skin, Bai Sangpi.Main product is in Anhui, Henan, Zhejiang, Jiangsu, Hunan and other places.Autumn Mo fallen leaves are adopted before secondary spring germination
Uproot portion, scrape off yellowish-brown tertia, longitudinally split, strip root skin, dry.First recorded in《Sheng Nong's herbal classic》, it is classified as middle warp, successive dynasties
Book on Chinese herbal medicine records, and is clinically common relieving cough and asthma Chinese medicine, sweet in flavor cold, property drop, it is main enter lung, with purging the lung of pathogenic fire heat, relieving asthma to be special
It is long, energy inducing diuresis to remove edema, regulating fluid apssage, and the respectful drop lung qi of energy, preferably stop for oedema real example, difficult urination, the edema of the face, or water drink
Lung, turgor breathe heavily the disease such as anxious.
Cape jasmine is the fruit of madder wort mountain Cape jasmine Gardenia jasminoides Ellis., and property bitter cold is nontoxic.Enter
The heart, liver, lung, stomach.Can clearing heat-fire, cool blood.Cure mainly pyreticosis restlessness of asrhenia type and insomnia, jaundice, gonorrhoea, quench one's thirst, hot eyes, pharyngalgia, haematemesis,
Bleeding from five sense organs or subcutaneous tissue, bloody flux, hematuria, pathopyretic ulcer, strain swelling and pain.It is clinically used for the diseases such as acute icteric hepatitis, hemostasis, bruise.
Vinegar grain, for rice, wheat, sorghum etc. make after vinegar remaining residue.For《Detailed outline》：" barley after making vinegar, acid, is slightly cold, nothing
Poison.", vinegar grain has sour fragrance, can promote the appetite of pig, preferably mixes and feeds with alkaline feed, to neutralize the acid in vinegar grain, to prevent house
Poultry poisoning.It is 5% of feed ration or so that vinegar grain, which is mainly used for pig feeding and ox, scale of feeding,.
The Chinese patent drug involved by Chinese patent drug medicinal material residue that the present invention uses is：Shuanghuanglian oral liquid, cyperus-amomum stomach mouth
Take liquid.
Wherein, Shuanghuanglian oral liquid according to《Chinese Pharmacopoeia in 2005, Shuanghuanglian oral liquid》Standard prepare.
【Prescription】Honeysuckle 375g, radix scutellariae 375g, Fructus Forsythiae 750g
【Preparation method】Three taste of the above, radix scutellariae add water to cook three times, for the first time 2 it is small when, second and third time it is each 1 it is small when, merge decoct
Liquid, filtration, filtrate concentration simultaneously adds 2mol/L hydrochloric acid solutions at 80 DEG C and adjusts pH value in right amount to 1.0~2.0, when insulation 1 is small,
Stand 12 it is small when, filtration, precipitation plus 6~8 times amount water, with 40% sodium hydroxide solution adjust pH value to 7.0, then add equivalent second
Alcohol, is stirred to dissolve, filtration, and filtrate adjusts pH value with 2mol/L hydrochloric acid solutions and keeps the temperature 30 minutes to 2.0,60 DEG C, stands 12 small
When, filtration, it is 7.0 that precipitation is washed till pH value with ethanol, and recycling ethanol is spare；After honeysuckle, Fructus Forsythiae add water temperature to soak 30 minutes, decoct
It is secondary, every time 1.5 it is small when, collecting decoction, filtration, it is clear for 1.20~1.25 (70~80 DEG C) that filtrate is concentrated into relative density
Cream, ethanol is slowly added into when being cooled to 40 DEG C, alcohol content is sufficiently stirred up to 75%, stand 12 it is small when, leaching supernatant, residue
Add 75% appropriate amount of ethanol, stir evenly, when standing 12 is small, filtration merges ethanol, and recycling ethanol adds above-mentioned radix scutellariae to no alcohol taste
Extract, and add appropriate amount of water, pH value is adjusted to 7.0 with 40% sodium hydroxide solution, stirs evenly, when refrigeration (4~8 DEG C) 72 are small, filters
To cross, filtrate adds sucrose 300g, is stirred to dissolve, and it is appropriate and adjust pH value to 7.0 to add essence, adds water that 1000ml is made,
Stir evenly, when standing 12 is small, filtration is filling, sterilizing, to obtain the final product.
The medicinal material residue of Shuanghuanglian oral liquid is obtained, wherein containing radix scutellariae medicinal materials residue, traditional Chinese medicine honeysuckle residue,
Fructus Forsythiae medicinal material residue.
Wherein, cyperus-amomum stomach oral liquid according to《The authentication codes of WS3-B-3941-98》Prepared：
【Prescription】Rhizoma cyperi (vinegar system) 100g, fructus amomi 100g, Pogostemon cablin 100g, Poria cocos 100g, Cortex Magnoliae Officinalis (ginger system) 100g, the tuber of pinellia
(system) 100g, Rhizoma Atractylodis Macrocephalae (bran stir-fry) 100g, the dried immature fruit of citron orange (bran stir-fry) 100g, radix glycyrrhizae 50g, Amomum cardamomum (are shelled) 50g, dried orange peel 50g, the banksia rose
50g, jujube 40g, ginger (smash) 10g to pieces.
【Preparation method】14 taste of the above, takes rhizoma cyperi, Cortex Magnoliae Officinalis, Rhizoma Atractylodis Macrocephalae, the dried immature fruit of citron orange, dried orange peel, according under liquid extract and extract item
Percolation (annex I O), with 60% ethanol as solvent, when dipping 24 is small, slowly diacolation, it is about the 10 of crude drug amount to collect percolate
Times, liquid of filtering is spare.It is another to take Pogostemon cablin, fructus amomi, Amomum cardamomum, the banksia rose, ginger extraction volatile oil, the dregs of a decoction and Poria cocos, the tuber of pinellia, jujube,
Radix glycyrrhizae add water to cook it is secondary, every time 2 it is small when, filtration, filtrate cooling after add in above-mentioned liquid of filtering, stand 24 it is small when, filtration, filtrate
Ethanol is recycled, is concentrated into right amount, cane sugar powder 200g, preservative and above-mentioned volatile oil is added after cooling, about 1000ml is made, i.e.,
.
The medicinal material residue of cyperus-amomum stomach oral liquid is obtained, wherein containing rhizoma cyperi (vinegar system) medicinal material residue, fructus amomi medicinal material
Residue, Pogostemon cablin medicinal material residue, Poria cocos medicinal material residue, Cortex Magnoliae Officinalis (ginger system) medicinal material residue, the tuber of pinellia (system) medicinal material are remaining
Thing, Rhizoma Atractylodis Macrocephalae (bran stir-fry) medicinal material residue, the dried immature fruit of citron orange (bran stir-fry) medicinal material residue, licorice medicinal materials residue, Amomum cardamomum (are shelled) medicinal material
Residue, dried orange peel medicinal material residue, banksia rose medicinal material residue, jujube medicinal material residue, ginger (smash) medicinal material residue to pieces.
Embodiment
The present invention is described in detail in following embodiments.Various raw materials used in the present invention and items of equipment are conventional city
Product is sold, can be bought and directly obtained by market.
Embodiment 1
Take 5 grams of root of phragmites communis, 40 grams of sweet wormwood, 15 grams of the root bark of white mulberry, 15 grams of cape jasmine, 8000 grams of dregs of beans.
Chinese medicine is mixed, is crushed, adds 15 times of water, is decocted 3 times, each 45min, filtration, liquid is concentrated to relative density
For 1.15g/ml, admix in dregs of beans, after exhaustion, covered, isolated between two layers with gauze, 30 with the Chinese medicine residue decocted
DEG C closed culture 4 days, ferment on yellow clothes all over when, take out, remove the dregs of a decoction, slightly dry in the air, put closed culture 20 days in 30 DEG C, to abundant
When fermentation, fragrance overflow, take out, it is dry, to obtain the final product.
Embodiment 2
Take 5 grams of root of phragmites communis, 40 grams of sweet wormwood, 15 grams of the root bark of white mulberry, 15 grams of cape jasmine, 8000 grams of corn flour.
Chinese medicine is mixed, is crushed, adds 15 times of water, is decocted 3 times, each 45min, filtration, liquid is concentrated to relative density
For 1.15g/ml, admix in corn flour, after exhaustion, covered with the Chinese medicine residue decocted, isolated between two layers with gauze,
30 DEG C of closed cultures 4 days, ferment on yellow clothes all over when, take out, remove the dregs of a decoction, slightly dry in the air, put closed culture 20 days in 30 DEG C, to filling
When distributing ferment, fragrance spilling, take out, it is dry, to obtain the final product.
Embodiment 3
Take 5 grams of root of phragmites communis, 40 grams of sweet wormwood, 15 grams of the root bark of white mulberry, 15 grams of cape jasmine, 8000 grams of dregs of beans, 40 grams of vinegar grain.
Chinese medicine is mixed, is crushed, adds 15 times of water, is decocted 3 times, each 45min, filtration, liquid is concentrated to relative density
For 1.15g/ml, admix in dregs of beans, vinegar grain, after exhaustion, covered with the Chinese medicine residue decocted, between two layers with gauze every
From, in 30 DEG C of closed cultures 4 days, ferment on yellow clothes all over when, take out, remove the dregs of a decoction, slightly dry in the air, put closed culture 20 in 30 DEG C
My god, when being overflowed to abundant fermentation, fragrance, take out, it is dry, to obtain the final product.
Embodiment 4
Take 5 grams of root of phragmites communis, 40 grams of sweet wormwood, 15 grams of the root bark of white mulberry, 15 grams of cape jasmine, 8000 grams of corn flour, 40 grams of vinegar grain.
Chinese medicine is mixed, is crushed, adds 15 times of water, is decocted 3 times, each 45min, filtration, liquid is concentrated to relative density
For 1.15g/ml, admix in corn flour, vinegar grain, after exhaustion, covered with the Chinese medicine residue decocted, between two layers with gauze every
From, in 30 DEG C of closed cultures 4 days, ferment on yellow clothes all over when, take out, remove the dregs of a decoction, slightly dry in the air, put closed culture 20 in 30 DEG C
My god, when being overflowed to abundant fermentation, fragrance, take out, it is dry, to obtain the final product.
Embodiment 5
Take 5 grams of root of phragmites communis, 40 grams of sweet wormwood, 15 grams of the root bark of white mulberry, 15 grams of cape jasmine, 8000 grams of dregs of beans, 40 grams of vinegar grain, swap buffers mouth
Take 800 grams of the medicinal material residue of liquid.
Chinese medicine is mixed, is crushed, adds 15 times of water, is decocted 3 times, each 45min, filtration, liquid is concentrated to relative density
For 1.15g/ml, admix in dregs of beans, vinegar grain, it is remaining with the Chinese medicine residue, the medicinal material of Shuanghuanglian oral liquid decocted after exhaustion
Thing covers, and is isolated with gauze between two layers, in 30 DEG C of closed cultures 4 days, ferment on yellow clothes all over when, take out, remove the dregs of a decoction, slightly
Dry in the air, put closed culture 20 days in 30 DEG C, when being overflowed to abundant fermentation, fragrance, take out, it is dry, to obtain the final product.
Embodiment 6
Take 5 grams of root of phragmites communis, 40 grams of sweet wormwood, 15 grams of the root bark of white mulberry, 15 grams of cape jasmine, 8000 grams of corn flour, 40 grams of vinegar grain, swap buffers
800 grams of the medicinal material residue of oral liquid.
Chinese medicine is mixed, is crushed, adds 15 times of water, is decocted 3 times, each 45min, filtration, liquid is concentrated to relative density
For 1.15g/ml, admix in corn flour, vinegar grain, it is residual with Chinese medicine residue, the medicinal material of Shuanghuanglian oral liquid decocted after exhaustion
Excess covers, and is isolated with gauze between two layers, in 30 DEG C of closed cultures 4 days, ferment on yellow clothes all over when, take out, remove the dregs of a decoction,
Slightly dry in the air, put closed culture 20 days in 30 DEG C, when being overflowed to abundant fermentation, fragrance, take out, it is dry, to obtain the final product.
Embodiment 7
Take 5 grams of root of phragmites communis, 40 grams of sweet wormwood, 15 grams of the root bark of white mulberry, 15 grams of cape jasmine, 8000 grams of dregs of beans, 40 grams of vinegar grain, swap buffers mouth
Take 800 grams of the medicinal material residue of liquid.
Chinese medicine is mixed, is crushed, adds 15 times of water, is decocted 3 times, each 45min, filtration, liquid is concentrated to relative density
For 1.15g/ml, admix in dregs of beans, vinegar grain, it is residual with Chinese medicine residue, the medicinal material of cyperus-amomum stomach oral liquid decocted after exhaustion
Excess covers, and is isolated with gauze between two layers, in 30 DEG C of closed cultures 4 days, ferment on yellow clothes all over when, take out, remove the dregs of a decoction,
Slightly dry in the air, put closed culture 20 days in 30 DEG C, when being overflowed to abundant fermentation, fragrance, take out, it is dry, to obtain the final product.
Embodiment 8
Take 5 grams of root of phragmites communis, 40 grams of sweet wormwood, 15 grams of the root bark of white mulberry, 15 grams of cape jasmine, 8000 grams of corn flour, 40 grams of vinegar grain, swap buffers
800 grams of the medicinal material residue of oral liquid.
Chinese medicine is mixed, is crushed, adds 15 times of water, is decocted 3 times, each 45min, filtration, liquid is concentrated to relative density
For 1.15g/ml, admix in corn flour, vinegar grain, after exhaustion, with Chinese medicine residue, the medicinal material of cyperus-amomum stomach oral liquid decocted
Residue covers, and is isolated with gauze between two layers, in 30 DEG C of closed cultures 4 days, ferment on yellow clothes all over when, take out, remove medicine
Slag, slightly dries in the air, and puts closed culture 20 days in 30 DEG C, when being overflowed to abundant fermentation, fragrance, takes out, dry, to obtain the final product.
Embodiment 9
Take 5 grams of root of phragmites communis, 40 grams of sweet wormwood, 15 grams of the root bark of white mulberry, 15 grams of cape jasmine, 8000 grams of dregs of beans.Chinese medicine is mixed, is crushed,
15 times of water are added, are decocted 3 times, each 45min, filtration, it is 1.15g/ml that liquid, which is concentrated to relative density, is admixed in dregs of beans, is done
It is dry, up to contrast product A.
Take 5 grams of root of phragmites communis, 40 grams of sweet wormwood, 15 grams of the root bark of white mulberry, 15 grams of cape jasmine, 8000 grams of corn flour.Mix Chinese medicine, powder
It is broken, 15 times of water are added, are decocted 3 times, each 45min, filtration, it is 1.15g/ml that liquid, which is concentrated to relative density, is admixed in dregs of beans,
It is dry, up to contrast product B.
Urase also known as urea hydroamidase, its relative molecular mass are 120000~130000, are raised in beans such as soybean
There is the quite high urase of activity in material.To animal body and the most important side effect of environment, it can also directly cause dynamic urase
Thing urethra and alimentary infection, the formation, catheter case-hardening, pyelonephritis and hepatic coma with kidney stone are related.Both at home and abroad
A kind of indicator enzyme all using urase as anti-nutritional factors in detection dregs of beans.
According to《Distinct methods measure the comparative studies of soybean urease activity》(《Feed wide-angle》, 2008 (21)) method,
The product comparison of the embodiment of the present invention 1 declines 38.2% than the content of urase in product A, and the product pH of the embodiment of the present invention 1 is
The product PH6.86 of 6.83, contrast product A.The product comparison of the embodiment of the present invention 3 declines than the content of urase in product A
57.1%, the product PH of the embodiment of the present invention 3 is 6.82, the product PH6.86 of contrast product A.The product of the embodiment of the present invention 2
Content than urase in contrast product B declines 41.6%, and the product PH of the embodiment of the present invention 2 is 6.84, the product of contrast product B
PH6.87.The product comparison of the embodiment of the present invention 4 declines 62.4% than the content of urase in product B, the production of the embodiment of the present invention 4
Product PH is 6.81, the product PH6.87 of contrast product B.The present invention product urease activity than azymous product significantly under
Drop, but pH value not significant changes, this demonstrate the present invention product in the mouthfeel of feed it is preferably.
Embodiment 10
40 Landraces (original body mass 141.3 ± 6.7kg, initial 11.2 ± 1.4mm of back fat) are selected, are equally divided into 4 groups,
Metabolic cage feeds (2.38 × 0.63 × 1m).Test pig is placed in metabolic cage and raises, preparatory stage 6d, feeds corn-soybean meal basic day
Grain, 800g/100kg.
Formal experiment, on the basis of corn-soybean meal basal diet, feeds the product, right of embodiment 1-2 in three times daily
Than product A, contrast product B (embodiment 9 is shown in the preparation of contrast product A, B), 50 grams/100kg every time.Feed 50 grams in three times daily
Physiological saline/100kg, is blank control group；Continuous 14 days.
Basal diet is with reference to China《Swine rearing standard》(2004) prepare, daily ration is powder.Dry matter, thick egg in daily ration
White matter, calcium and total phosphorus respectively refer to National Standard of the People's Republic of China GB/T 6435-1986, GB/T6432-1994, GB/
The method measure that T6436-2002 and GB/T6437-2002 recommends.
After 14 days, weight is surveyed：
| Group | Weight (kg) | Back fat (mm) |
| 1 group of embodiment | 178.1±9.5 | 18.2±3.1 |
| 2 groups of embodiment | 175.3±8.3 | 16.7±2.7 |
| Contrast product A groups | 161.5±3.3 | 14.1±1.8 |
| Contrast product B groups | 163.4±7.5 | 13.7±2.9 |
| Blank control group | 151.2±6.7 | 12.8±3.5 |
Digestive enzyme activity measures
After digestion trial, from each group each repeat in respectively select test pig 5, totally 20.Fasting 24h, freely drinks
Water, is butchered after weighing.Abdominal cavity is splitted, ligatures each section of alimentary canal rapidly.Collect duodenum content, with measure trypsase and
The activity of pancreas chymotrypsin, amylase.The whole pancreas of clip, samples after weighing, to measure trypsase and pancreas chymotrypsin, form sediment
Powder enzymatic activity.
The contrast of the vigor of pancreas digestive ferment
| Pancreas | Trypsase | Pancreas chymotrypsin | Amylase |
| 1 group of embodiment | 351.5±21.7 | 507.3±31.2 | 263.2 soil 16.5 |
| 2 groups of embodiment | 346.3±20.1 | 511.7±21.9 | 259.3 soil 17.8 |
| Contrast product A groups | 304.3±10.5 | 413.2±22.8 | 203.6 soil 12.4 |
| Contrast product B groups | 310.1±12.3 | 432.7±35.5 | 212.7 soil 12.5 |
The contrast of the vigor of duodinum digestive enzyme
| Duodenum | Trypsase | Pancreas chymotrypsin | Amylase |
| 1 group of embodiment | 37.2±2.9 | 89.2±13.1 | 498.3 soil 27.9 |
| 2 groups of embodiment | 38.3±2.7 | 92.3±10.8 | 485.9 soil 31.3 |
| Contrast product A groups | 24.1±1.6 | 47.8±13.1 | 375.4 soil 20.1 |
| Contrast product B groups | 23.7±3.8 | 41.6±12.7 | 387.2 soil 21.4 |
It is as shown in the table for result of the test.After the Chinese herbal medicine fermentate that the present invention is supplemented in feed, pancreas, duodenal pancreas
Proteinase activity, pancreas chymotrypsin activity and amylase activity ratio control group are significantly increased (P<O.05).
Embodiment 11
Experimental animal selects 120-130 ages in days, and Laboratory Diagnosed is the sick pig of epidemic diarrhea.
Sick pig is isolated into individually raising, feeds basal diet, at random packet, every group 10；In corn-soybean meal basic day
On the basis of grain, feed in three times daily the product of embodiment 1,3,5,7, contrast product A, contrast product B (contrast product A, B
Embodiment 9 is shown in preparation), 50 grams/100kg every time；Pig feeding rush down dysentery health dissipates in three times daily, to specifications dosage, right for the positive
According to group；Physiological saline is fed daily, every time 50 grams/100kg；For blank control group；Experiment carries out 7 days altogether.
Efficacy assessment standard：Cure：Spiritual normal, feeding drinking-water is normal, and the clinical symptoms such as excrement is normal disappear, swine excrement
It is middle to have no Porcine epidemic diarrhea virus etc. through laboratory experiment detection.Do not cure：Clinical symptoms, which do not improve, even to be aggravated.
| Dead (head) | Cure (head) | Do not cure (head) | |
| Blank control group | 5 | 1 | 4 |
| Positive controls | 0 | 3 | 7 |
| 1 group of embodiment | 0 | 9 | 1 |
| 3 groups of embodiment | 0 | 9 | 1 |
| 5 groups of embodiment | 0 | 10 | 0 |
| 7 groups of embodiment | 0 | 10 | 0 |
| Contrast product A groups | 0 | 8 | 2 |
| Contrast product B groups | 0 | 8 | 2 |
Embodiment 12
The product of the present invention is to the effect after the young wean of pork pig
Certain boar farm, raising pork pig is 30 young, and about intestines heat, the disease of constipation occur for half porkling after the wean of 20 ages in days
Shape, swine excrement are yellow-white or canescence, and piglet spirit is depressed, loss of appetite, and slightly disorderly, matt, fear is cold for hair.At random by meat
Porkling is divided into two groups, every group 10.Continuous 7 days, feed the product of embodiment 3 in three times daily, every time 500 milligrams/100kg；Often
It feeds contrast product A products (embodiment 9 is shown in the preparation of contrast product A, B) in three times, every time 500 milligrams/100kg；Per natural gift
Domperidone is fed three times, every time 50 milligrams/100kg.
| Group | 2 age in days weight | 47 age in days weight |
| The product of embodiment 3 | 26.81±1.23kg | 61.72±1.58kg |
| Contrast product A groups | 26.70±1.52kg | 67.53±1.84kg |
| Domperidone | 26.57±1.91kg | 37.42±1.72kg |
Using the product of the product of embodiment 3, symptom has been alleviated after 1 day, and feed intake rises after 2 days, and state is substantially good
Turn.Drinking water administration is used within 3rd to the 7th day, whole porklings recoveries from illness, porkling weight substantially increases, and feed intake recovers normal.
Embodiment 13
Effect of the product of the present invention to broiler chicken：Raise table hens 900, be randomly divided into 3 groups, every group 300.Chicken age on the 2nd
Contrasted to 42 ages in days.
1st group is administration group, using 1 product of embodiment, is drunk water by 0.5% dilution, every time 5 grams/100kg；2nd group is pair
According to group, using contrast product A set products (embodiment 9 is shown in the preparation of contrast product A, B), fed by 0.5% dilution drinking-water control,
5 grams/100kg every time；3rd group is blank group, using common chicken feed, drinks water by physiological saline and compares feeding, its effect is as follows
It is shown：
| Group | 2 age in days weight | 47 age in days weight | Forage volume |
| 1 group of embodiment | 46.7±1.2g | 3.42±0.4kg | 5.32kg |
| Contrast product A groups | 46.2±1.8g | 2.78±0.8kg | 5.28kg |
| Blank group | 46.5±1.9g | 2.13±0.7kg | 5.30kg |
Foregoing description only proposes as the enforceable technical solution of the present invention, not as to its technical solution single in itself
Restrictive condition.
Claims (1)
1. a kind of composition for improving immunity of livestock, it is characterized in that：Take 5 grams of root of phragmites communis, 40 grams of sweet wormwood, 15 grams of the root bark of white mulberry, Cape jasmine
Sub 15 grams, 8000 grams of dregs of beans；Chinese medicine is mixed, is crushed, adds 15 times of water, is decocted 3 times, each 45min, filtration, liquid concentration
Be 1.15g/ml to density, admix in dregs of beans, after exhaustion, covered with the Chinese medicine residue decocted, between two layers with gauze every
From, in 30 DEG C of closed cultures 4 days, ferment on yellow clothes all over when, take out, remove the dregs of a decoction, slightly dry in the air, put closed culture 20 in 30 DEG C
My god, when being overflowed to abundant fermentation, fragrance, take out, it is dry, to obtain the final product.
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| CN107624990A (en) * | 2016-12-16 | 2018-01-26 | 江苏军曼农业科技有限公司 | A kind of turkey breeding feed and preparation method thereof |
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| 大青叶、芦根、青蒿治疗肺部急性感染;曹兴亚;《四川中医》;19851231(第1期);第7页左栏第1-2段，右栏倒数第2段 * |
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