CN1939425A - Animal medicament with heat-clearing, toxin-removing, blood-cooling and stasis-dispelling functions and its production - Google Patents
Animal medicament with heat-clearing, toxin-removing, blood-cooling and stasis-dispelling functions and its production Download PDFInfo
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- CN1939425A CN1939425A CN 200510015177 CN200510015177A CN1939425A CN 1939425 A CN1939425 A CN 1939425A CN 200510015177 CN200510015177 CN 200510015177 CN 200510015177 A CN200510015177 A CN 200510015177A CN 1939425 A CN1939425 A CN 1939425A
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- rhizoma fagopyri
- fagopyri dibotryis
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Abstract
A veterinary medicine with the functions of clearing heat, removing toxin and stasis and activating blood for treating the epidemic diseases of domestic animals and fowls is prepared from fagopyrum cymosum through pre-treating, decocting in water for 2 hr while using acid to regulate pH=2-5, filtering, decocting again for 1.5 hr while using alkali to regulate pH=8-9, filtering, collecting the decoction, drying and pulverizing.
Description
Technical field
The present invention relates to derive from the technical field of medicinal preparation (international Patent classificating number 35/79) of the product that contains not clear structure of plant, relating to the Chinese crude drug Rhizoma Fagopyri Dibotryis is the animal medicament and the method for making thereof of a kind of heat-clearing and toxic substances removing of feedstock production, blood circulation promoting and blood stasis dispelling function.
Background technology
Chinese medicine and pharmacy is one of important component part in the cultural treasure-house of China's medicine, and Chinese herbal medicine then is the culture rarity of China.Aspect animal medicine, traditional Chinese veterinary medicine is also playing crucial effect aspect the Clinics and Practices of livestock and poultry.
Rhizoma Fagopyri Dibotryis (different name Radix Et Rhizoma Fagopyri Tatarici, Semen Fagopyri Esculenti Radix Notoginseng, Jinsuoyinkai ') is one of medical material of heat-clearing and toxic substances removing commonly used in the Chinese medicine for animals, and its pharmacological action of modern study: water decoction all has inhibitory action to pathogenic bacterias such as staphylococcus aureus, dysentery bacteriums.2000 editions veterinary drug allusion quotations are recorded its medical material and are used for the treatment of poultry laryngopharynx swelling and pain, lung abscess nose pus, acute mastitis, dysentery, carbuncle pyogenic infections from tumour or sore.
In clinical use; because modern large-scale cultivation; directly the Chinese medicine crude drug is carried out the mixed feeding administration and usually cause problems such as administration inconvenience, abnormal smells from the patient is dense, absorbance is low; make the Rhizoma Fagopyri Dibotryis drug effect not bring into play fully; and the Rhizoma Fagopyri Dibotryis preparation takes the decocting in water alcohol deposition method to extract usually, has lost the mass efficient composition.Do not retrieve at present the application of the smart powder of Rhizoma Fagopyri Dibotryis on livestock and poultry pestilence as yet, on human, be commonly used to treat lung abscess, measles pneumonia, peritonsillar abscess.The extractive technique of Rhizoma Fagopyri Dibotryis is the extractive technique of human medicine often, and technical sophistication, cost height are used for poultry medication and uneconomical; And the said extracted process usually can be removed the nutritional labelings such as protein in the Chinese medicine, and this has improved aquaculture cost virtually again for livestock and poultry cultivation.
Summary of the invention
The objective of the invention is for a kind of smart powder preparation of Rhizoma Fagopyri Dibotryis with functions such as heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling is provided.Be used to cure mainly diseases such as poultry laryngopharynx swelling and pain, lung abscess nose pus, acute mastitis, dysentery, carbuncle pyogenic infections from tumour or sore.But mixed feeding also can be mixed the drink administration, simultaneously again can be as the raw material of further preparation.Antibiotherapy is generally adopted in bacillary, the viral infection of treatment domestic animal at present, heavy dose of antibiotic that feeds also makes the intravital normal flora of machine suffer to destroy and imbalance in the treatment disease, causes producing in the body residual in animal foodstuff of Resistant strain and medicine.Rhizoma Fagopyri Dibotryis nature and flavor hardship, be slightly cold, can go into stomach, lung meridian, pathogenic bacterias such as staphylococcus aureus, dysentery bacterium are had certain inhibitory action.And the present invention---the dysentery that the smart powder of Rhizoma Fagopyri Dibotryis causes for bacterial virus can be eliminated symptom quickly, promotes body recovery.The smart powder side effect of Rhizoma Fagopyri Dibotryis is little, the no obvious toxic and side effects in oral back, and do not produce drug resistance after using, body is interior without any drug residue.
It is comparatively simple that another object of the present invention just provides a kind of extracting method, is used for the lower-cost a kind of method for making with animal medicament of heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling function of the treatment of livestock and poultry pestilence.
The invention provides a kind of animal medicament in order to reach the foregoing invention purpose, it is characterized in that this medicament is is the medicament that raw material is made by Rhizoma Fagopyri Dibotryis with heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling function.
Dose processing method: Rhizoma Fagopyri Dibotryis is removed impurity afterwash, cutting, grind then, cross 60 mesh sieves, standby; At first the Rhizoma Fagopyri Dibotryis after handling is extracted: with the water extraction of 8 times of amounts of medical material, extracting temperature is 95 ± 3 ℃, and being adjusted to pH with 10% acid for the first time is 2-5, decocts 2 hours; Extract for the second time 8 times that will water add to medical material weight, regulating pH with 10% alkali is 8-9, and extraction time is 1.5 hours, and medicinal liquid filters the back merging respectively, and filtrate is concentrated into relative density and is about 1.34-1.36g/cm
3, 70 ℃ thick paste, thick paste carries out vacuum drying, pulverizes; Or merging rear filtrate, to be concentrated into relative density be 1.10-1.20g/cm
3, 70 ℃ clear paste, spray drying promptly gets the smart powder of Rhizoma Fagopyri Dibotryis, and yield is 7.8%-11.6%.
A kind of method for making with animal medicament of heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling function, comprise the Rhizoma Fagopyri Dibotryis medical material is removed impurity afterwash, cutting, grind then, cross 60 mesh sieves, standby, it is characterized in that at first the Rhizoma Fagopyri Dibotryis after handling being extracted: with the water extraction of 8 times of amounts of medical material, extracting temperature is 95 ± 3 ℃, for the first time being adjusted to pH with 10% acid is 2-5, decocts 2 hours; Extract for the second time 8 times that will water add to medical material weight, pH is 8-9 with the adjusting of 10% alkali, and extraction time is 1.5 hours; Medicinal liquid filters the back respectively and merges, and promptly gets the Rhizoma Fagopyri Dibotryis extracting solution, and filtrate is concentrated into relative density and is about 1.34-1.36g/cm
3, 70 ℃ thick paste, thick paste carries out vacuum drying, pulverizes; Or merging rear filtrate, to be concentrated into relative density be 1.10-1.20g/cm
3, 70 ℃ clear paste, spray drying promptly gets the smart powder of Rhizoma Fagopyri Dibotryis.(yield is 7.8%-11.6%).
According to described animal medicament and method for making thereof, it is characterized in that described acid is hydrochloric acid or lactic acid with heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling function; Alkali is to regulate pH value with sodium hydroxide.
Finished product of the present invention can be made multiple dosage form as required, adds appropriate amount of auxiliary materials and can be used as injection, is used for intramuscular injection; Directly medicinal can mixed feeding or mix drink; Carry out intestinal perfusion after also can be water-soluble with powder.
It is respond well to confirm that by experiment this medicine is used for the treatment of Pullorum Disease, and experimental result is as follows:
The experiment medicine: the smart powder of Rhizoma Fagopyri Dibotryis, control drug is that the Rhizoma Fagopyri Dibotryis decoction pieces is made Golden Buckwheat Rhizome after crushed.
Laboratory animal: 350 AA mixing meat young birds, available from Tianjin side's big fowl industry company limited.Test chicken is without the Pullorum Disease vaccine immunity, and male and female has concurrently, transports laboratory immediately back after going out shell, raises routinely on adjustable temperature control net cage, feeds complete feedstuff, free choice feeding and drinking-water, and carry out clinical observation.Artificial challenge's Pullorum Disease during raising to 7 age in days infects the back and observed 5 days.Test chicken body weight and grouping situation see Table 1.
Seed culture of viruses: the Pullorum Disease Salmonella is provided by TanJin Agricultural College microorganism teaching and research room.Before the use, the virulent strain of preservation is the inoculation ordinary flat earlier.Cultivate after 24 hours, select colonies typical in meat soup, cultivate after 18 hours for 37 ℃ and take out.Calculating turbidity unit with the Maxwell turbidimetry, is 5 * 10
6Bacterium/ml.
Experimental technique: per os gavaged Pullorum Disease Salmonella liquid 1ml when chickling was supported to 7 ages in days, contained 500,000,000 bacterium approximately.Cardinal symptom for depressed, the appetite of spirit descends, the feather pine disorderly, sagging, the lethargy of closing one's eyes of both wings, drop-head stays and stands, draws white or kermesinus loose stool.The visible lung of postmortem is kermesinus, and liver has a large amount of point-like or striated hemorrhage, and there is turbid liquid in the thoracic cavity, and pericardium has the cellulose calmness, and kidney is pale, urate deposition is arranged, and caseous substance is arranged in the caecum.Part night blindness enteral is mixed with blood, and is all separable to a large amount of Pullorum Disease Salmonellas by liver, spleen, lung.The proof experimental chicken is infected chicken Hakuri Salmonella.
Therapeutic evaluation
Mortality rate: the Pullorum Disease classical symptom occurs and death in that duration of test is all, necropsy has the characteristic pathological changes, and separation and Culture goes out Pullorum Disease Salmonella person from liver, spleen, is judged to infect deadly, calculates mortality rate of each group.
Cure rate: allly recover normal person and be judged to healing, account for the ratio calculating cure rate of this group test chicken according to curing chicken at duration of test various transference cures after the drinking-water medication.
Weightening finish: the body weight of every chicken during according to on-test and end, the weightening finish of calculating every chicken.With the weightening finish of normal healthy controls (negative control) group is 100%, and each group weightening finish is compared with the weightening finish of normal healthy controls group, calculates the relative weight gain rate of each group.
The grouping of table 1 experimental chicken
| Numbering | Group | Drug level (g/ only) | Quantity (only) | Body weight (g) | Handle |
| 1 2 3 4 5 6 7 | Dosage group A low dose group B medicine contrasts safe control group among the normal healthy controls infection contrast A high dose group A | 0.15 0.075 0.035 2 1.5 | 50 50 50 50 50 50 50 | 146.54±13.34 148.85±13.44 143.87±10.89 144.47±11.68 147.47±11.83 146.55±10.65 145.36±10.68 | Do not infect, not administration is infected, not administration mixes drink, infect and mix drink, infect and mix drink, infect and mix drink, infect and mix drink, do not infect |
Experimental result sees the following form:
The smart powder of table 2 Rhizoma Fagopyri Dibotryis is to the therapeutic effect of the compound respiratory tract disease of chicken
| Numbering | Group | Death toll (only) | Mortality rate (%) | Cure rate (%) | Weightening finish (g) | The relative weight gain rate (%) |
| 1 2 3 4 5 6 | Normal healthy controls infects dosage A low dosage B medicine contrast among the contrast A high dose A | 0 14 0 3 8 6 | 0 28 0 6 16 12 | ---- 100 94 84 88 | 324.86 242.27 317.42 296.81 276.03 268.98 | 100 74.6 97.7 91.4 84.9 82.8 |
Annotate: the A medicine refers to that the smart powder B of Rhizoma Fagopyri Dibotryis medicine refers to Golden Buckwheat Rhizome
Find out from experimental result, the matched group that is higher than evident in efficacy of the smart powder group of Rhizoma Fagopyri Dibotryis, (10 times of amounts are recommended oral by the safety experiment to healthy chicken simultaneously, logotype five days), the clinical manifestation of no abnormality seen between the operating period illustrates that said preparation does not have obvious influence to healthy chicken, and is safe in utilization.
Beneficial effect of the present invention: above-mentioned method for making has been broken the traditional human Chinese medicine secondary neutral water extraction or the method for decocting in water precipitate with ethanol, leaching process adopts partly bionical---sour earlier back alkaline extraction, the effective ingredient that has farthest kept Rhizoma Fagopyri Dibotryis, be particularly suitable for the poultry medication, in leaching process, do not use organic solvent, reduced the step that also will extract organic solvent, avoided the organic solvent residue problem with behind the organic solvent extraction.Protect the effective ingredient in the medicine to greatest extent, reduced production cost.
By zoopery, confirmed that the smart treated powder domestic animal of Rhizoma Fagopyri Dibotryis, poultry diarrhea have excellent curative, played the effect of heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling.
Confirmed the purposes of the smart powder of Rhizoma Fagopyri Dibotryis on the treatment livestock and poultry pestilence.Since process using water extraction of the present invention, the method for sour earlier back alkali, water temperature raising degree is higher, has kept the effective ingredient in the medicine, and the active component in the smart powder has overcome the difficult difficulty that absorbs of Rhizoma Fagopyri Dibotryis crude drug.After water is carried, do not adopt alcohol deposition method, kept the nutritions such as protein in the medicine, after poultry are taken in, help the growth of poultry, thereby improved the economic benefit of culturing, reduced the medicine production cost.Generally speaking reduced aquaculture cost, solved because of Resistant strain exists and used the inoperative difficulty of antibiotic therapy.Be used for the treatment of domestic animal, tame avian infectious eqpidemic disease has excellent curative, played the effect of heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling.
The specific embodiment:
Embodiment 1: depletion Semen Fagopyri Esculenti medical material 100kg, with the Rhizoma Fagopyri Dibotryis raw material wash on request, pick up, cut, dry, pulverized behind 60 mesh sieves standby.Extracting temperature is 95 ± 3 ℃, and amount of water is 8 times of medical material weight for the first time, the acid for adjusting pH to 3 with 10%, and extraction time is 2 hours; For the second time amount of water still be 8 times of medical material weight, and with 10% alkali adjusting pH to 8.5, extraction time is 1 hour.80 ℃ of thickening temperatures, vacuum-0.09Mpa, being concentrated into proportion is 1.20g/cm
3(80 ℃).Spray drying or vacuum decompression crushed after being dried promptly get the smart powder 8.2kg (yield is 8.2%) of Rhizoma Fagopyri Dibotryis.
Certain chicken house chicken group infected chicken Hakuri, white dysentery appears in most of chicken group, cuts open symptoms such as the visible hepatosplenomegaly of inspection, does not see obvious improvement with antibiotic medicine treatment back effect.Adopt medicine of the present invention, 0.15g/ only/day, freely drink water, carry out five days by a definite date treatment after, most of sick fowl disease close friend commentaries on classics, symptom disappears substantially, cure rate has reached 92%.
Embodiment 2: depletion Semen Fagopyri Esculenti medical material 100kg, method for making is with embodiment 1.Can get the smart powder 10.2kg (yield is 10.2%) of Rhizoma Fagopyri Dibotryis after the extraction.Certain pig farm piglet infects yellow scour of piglet, and state of an illness weight differs, and adds medicine of the present invention, 0.3g/kg feedstuff, logotype 5 days in feedstuff.Most of sick swine diseases feelings begin to take a turn for the better gradually after 5 days, normal feed of beginning and drinking-water.After continuing to strengthen treatment, be almost recovered.
Claims (3)
1, a kind of animal medicament with heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling function is characterized in that being is the medicament that raw material is made by Rhizoma Fagopyri Dibotryis
Dose processing method: Rhizoma Fagopyri Dibotryis is removed impurity afterwash, cutting, grind then, cross 60 mesh sieves, standby; At first the Rhizoma Fagopyri Dibotryis after handling is extracted: with the water extraction of 8 times of amounts of medical material, extracting temperature is 95 ± 3 ℃, and being adjusted to pH with 10% acid for the first time is 2-5, decocts 2 hours; Extract for the second time 8 times that will water add to medical material weight, regulating pH with 10% alkali is 8-9, and extraction time is 1.5 hours, and medicinal liquid filters the back merging respectively, and filtrate is concentrated into relative density and is about 1.34-1.36g/cm
3, 70 ℃ thick paste, thick paste carries out vacuum drying, pulverizes; Or merging rear filtrate, to be concentrated into relative density be 1.10-1.20g/cm
3, 70 ℃ clear paste, spray drying promptly gets the smart powder of Rhizoma Fagopyri Dibotryis, and yield is 7.8%-11.6%.
2, a kind of method for making with animal medicament of heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling function, comprise the Rhizoma Fagopyri Dibotryis medical material is removed impurity afterwash, cutting, grind then, cross 60 mesh sieves, standby, it is characterized in that at first the Rhizoma Fagopyri Dibotryis after handling being extracted: with the water extraction of 8 times of amounts of medical material, extracting temperature is 95 ± 3 ℃, for the first time being adjusted to pH with 10% acid is 2-5, decocts 2 hours; Extract for the second time 8 times that will water add to medical material weight, pH is 8-9 with the adjusting of 10% alkali, and extraction time is 1.5 hours; Medicinal liquid filters the back respectively and merges, and promptly gets the Rhizoma Fagopyri Dibotryis extracting solution, and filtrate is concentrated into relative density and is about 1.34-1.36g/cm
3, 70 ℃ thick paste, thick paste carries out vacuum drying, pulverizes; Or merging rear filtrate, to be concentrated into relative density be 1.10-1.20g/cm
3, 70 ℃ clear paste, spray drying promptly gets the smart powder of Rhizoma Fagopyri Dibotryis, and yield is 7.8%-11.6%.
3, according to claim 1 and 2 described animal medicament and method for makings thereof, it is characterized in that described acid is hydrochloric acid or lactic acid with heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling function; Alkali is to regulate pH value with sodium hydroxide.
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| CN103844268A (en) * | 2014-03-30 | 2014-06-11 | 柴华 | Processing method of nutrient wild buckwheat powder |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103844268A (en) * | 2014-03-30 | 2014-06-11 | 柴华 | Processing method of nutrient wild buckwheat powder |
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