CN1927254A - Medicament for animals with heat clearing and detoxicating, blood cooling and hemostatic functions and preparing method thereof - Google Patents
Medicament for animals with heat clearing and detoxicating, blood cooling and hemostatic functions and preparing method thereof Download PDFInfo
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- CN1927254A CN1927254A CN 200510015056 CN200510015056A CN1927254A CN 1927254 A CN1927254 A CN 1927254A CN 200510015056 CN200510015056 CN 200510015056 CN 200510015056 A CN200510015056 A CN 200510015056A CN 1927254 A CN1927254 A CN 1927254A
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Abstract
The invention involves the field of veterinary medicine technology, particularly in relation to veterinary medicine which takes euphorbiae humifusae as materials and has the function of clearing away the heat-evil and expelling superficial evils, cooling blood to stop bleeding and its preparation method. After refining the euphorbiae humifusa medicinal substances, wash and cut it into pieces, then extract the ground euphorbiae humifusa: extract it with eight times the weight of water of the medicine, the extraction temperature is 95 +- 3DEG C, accommodate its pH to 2-5 with 10% acid for the first extraction, decocte for 2 hours; still add the water to eight times the weight of the medicine for the second extraction and accommodate its pH to 8-9 with 10% alkali, 1.5 hours extraction. Merge the physic liquor after they are filtrated respectively, after drying, pulverization euphorbiae humifusa refined powder is obtained, which has good therapeutic effect in treating livestock and poultry diseases. Since the invention technology adopts water extraction, extracting first with acid then with base, the active ingredients of the drug is retained, effective component of the refined powder overcome the difficulty of hard absorption of euphorbiae humifusa original medicinal substances. Thereby the invention enhances the economic benefits of culture and reduces drug production costs.
Description
Technical field
The invention belongs to the technical field of herbal medicine, the present invention relates to the Chinese crude drug Herba Euphorbiae Humifusae is the animal medicament and the method for making thereof of a kind of heat-clearing and toxic substances removing of feedstock production, blood cooling and hemostatic functions.
Background technology
Chinese medicine and pharmacy is one of important component part in the cultural treasure-house of China's medicine, and Chinese herbal medicine then is the culture rarity of China.Aspect animal medicine, traditional Chinese veterinary medicine is also playing crucial effect aspect the Clinics and Practices of livestock and poultry.
(the different name Herba Chenopodii Hybridi comes from " detailed outline " to Herba Euphorbiae Humifusae; The red filament grass comes from " the Hangzhou medicine is planted will "; Milk infantile malnutrition grass comes from " Zhejiang traditional herbal medicine "; NAIJIANGCAO comes from " Fujian traditional herbal medicine ") be one of heat-clearing and toxic substances removing the most frequently used in the Chinese medicine for animals, cooling blood for hemostasis medical material.2000 editions veterinary drug allusion quotations are recorded its medical material and are used for livestock and poultry diarrhea, and the intestinal Huang is had blood in stool, hematuria, hemoptysis, injury from falling down, the carbuncle malignant boil is used for diseases such as fish enteritis, gill rot simultaneously, and its main usage is that pulverizing medicinal materials becomes last and feeds, consumption is bigger than normal, main cause is that medicine just excretes in the body without absorbing in vivo, birds particularly, because of its distinctive intestinal short, can not digest cellulose etc. physiological characteristics, cause a large amount of medical material wastes.
In clinical use; because modern large-scale cultivation; directly the Chinese medicine crude drug is carried out the mixed feeding administration and usually cause problems such as administration inconvenience, abnormal smells from the patient is dense, absorbance is low; make the Herba Euphorbiae Humifusae drug effect not bring into play fully; and common extraction method is to adopt common decocting in water precipitate with ethanol to extract; not only waste a large amount of ethanol, also lost the mass efficient composition simultaneously.Do not retrieve at present the application of the smart powder of Herba Euphorbiae Humifusae on livestock and poultry pestilence as yet, the extractive technique of Herba Euphorbiae Humifusae usually is the extractive technique of human medicine, and technical sophistication, cost height are used for poultry medication and uneconomical; And the said extracted process usually can be removed the nutritional labelings such as protein in the Chinese medicine, and this has improved aquaculture cost virtually again for livestock and poultry cultivation.
Summary of the invention
To the objective of the invention is in order addressing the above problem, a kind of smart powder preparation of Herba Euphorbiae Humifusae with functions such as heat-clearing and toxic substances removing, cooling blood for hemostasis to be provided.Be used to cure mainly the animal dysentery, the intestinal Huang is had blood in stool, hematuria, and hemoptysis, injury from falling down, the carbuncle malignant boil be used for diseases such as fish enteritis, gill rot simultaneously, but mixed feeding also can be mixed the drink administration, simultaneously again can be as the raw material of further preparation.The chemical drugs therapy is generally adopted in bacillary, the viral infection of treatment domestic animal at present, heavy dose of chemical drugs that feeds also makes the intravital normal flora of machine suffer to destroy and imbalance in the treatment disease, causes producing in the body residual in animal foodstuff of Resistant strain and medicine.Herba Euphorbiae Humifusae property suffering, flat is gone into liver, large intestine channel, and multiple pathogenic coccus and bacillus are had tangible bacteriostasis.And the present invention---the digestive system infection that the smart powder of Herba Euphorbiae Humifusae causes for virus can comparatively fast be eliminated symptom, promotes body recovery.The smart powder side effect of Herba Euphorbiae Humifusae is little, the no obvious toxic and side effects in oral back, and do not produce drug resistance after using, body is interior without any drug residue.
Technical scheme of the present invention is: a kind of application and the method for making thereof of the smart powder of Herba Euphorbiae Humifusae on poultry with heat-clearing and toxic substances removing, blood cooling and hemostatic functions.
The invention provides a kind of have heat-clearing and toxic substances removing, blood cooling and hemostatic functions animal medicament, it is characterized in that this medicament is is the medicament that raw material is made by Herba Euphorbiae Humifusae.
Dose processing method: Herba Euphorbiae Humifusae is removed impurity afterwash, cutting, grind then, cross 60 mesh sieves, standby; At first the Herba Euphorbiae Humifusae after handling is extracted: with the water extraction of 8 times of amounts of medical material, extracting temperature is 95 ± 3 ℃, and being adjusted to pH with 10% acid for the first time is 2-5, decocts 2 hours; Extract for the second time 8 times that will water add to medical material weight, regulating pH with 10% alkali is 8-9, and extraction time is 1.5 hours, and medicinal liquid filters the back merging respectively, and filtrate is concentrated into relative density and is about 1.34-1.36g/cm
370 ℃ thick paste, thick paste carries out vacuum drying, pulverizes; Or merging rear filtrate, to be concentrated into relative density be 1.10-1.20g/cm
3Clear paste, spray drying promptly gets the smart powder of Herba Euphorbiae Humifusae, yield is 13.2%-19.8%.
A kind of method for making with animal medicament of heat-clearing and toxic substances removing, blood cooling and hemostatic functions, comprise the Herba Euphorbiae Humifusae medical material is removed impurity afterwash, cutting, grind then, cross 60 mesh sieves, standby, it is characterized in that at first the Herba Euphorbiae Humifusae after handling being extracted: with the water extraction of 8 times of amounts of medical material, extracting temperature is 95 ± 3 ℃, for the first time being adjusted to pH with 10% acid is 2-5, decocts 2 hours; Extract for the second time 8 times that will water add to medical material weight, pH is 8-9 with the adjusting of 10% alkali, and extraction time is 1.5 hours; Medicinal liquid filters the back respectively and merges, and promptly gets the Herba Euphorbiae Humifusae extracting solution, and the Herba Euphorbiae Humifusae extracting solution is concentrated into relative density and is about 1.34-1.36g/cm
370 ℃ thick paste, thick paste carries out vacuum drying, pulverizes; Or the Herba Euphorbiae Humifusae extracting solution to be concentrated into relative density be 1.10-1.20g/cm
3Clear paste, spray drying promptly gets the smart powder (yield is 13.2%-19.8%) of Herba Euphorbiae Humifusae.
Have heat-clearing and toxic substances removing, blood cooling and hemostatic functions animal medicament and a method for making thereof according to described, it is characterized in that described acid is hydrochloric acid or lactic acid; Alkali is to regulate pH value with sodium hydroxide.
Finished product of the present invention can be made multiple dosage form as required, adds appropriate amount of auxiliary materials and can be used as injection, is used for intramuscular injection; Directly medicinal can mixed feeding or mix drink; Carry out breast or intestinal perfusion after also can be water-soluble with powder.
It is respond well to confirm that by experiment this medicine is used for the treatment of Pullorum Disease, and experimental result is as follows: the experiment medicine: the smart powder of Herba Euphorbiae Humifusae, control drug is that the Herba Euphorbiae Humifusae decoction pieces is made the Herba Euphorbiae Humifusae powder after crushed.
Laboratory animal: 15 350 of age in days Ai Wei mattress broiler (providing) by the chicken farm, Tianjin, the sealing chicken coop is raised, and the complete feed of feeding is freely drunk water.
Seed culture of viruses: the Pullorum Disease Salmonella is that microorganism teaching and research room provides by the TanJin Agricultural College animal science.Experimental technique: laboratory animal is divided into 7 groups at random, and first group is the normal healthy controls group, does not infect not administration; Second group for infecting matched group, infection, not administration; The 3rd group is the smart powder high dose group of Herba Euphorbiae Humifusae, infects 0.1g/ chicken back every day, logotype 5 days; The 4th group is dosage group in the smart powder of Herba Euphorbiae Humifusae, infects 0.05g/ chicken back every day, logotype 5 days; The 5th group is the smart powder low dose group of Herba Euphorbiae Humifusae, infects 0.025g/ chicken back every day, logotype 5 days; The 6th group is Herba Euphorbiae Humifusae medical material matched group, infects 2g/ chicken back every day, logotype 5 days; The 7th group is the smart powder safe dose of Herba Euphorbiae Humifusae group, do not infect, every day 1g/ chicken, logotype 5 days.
Experimental session, every day, observed and recorded was added up effective percentage, mortality rate and the relative weight gain rate after the course of treatment.
Chicken number * 100 before effective percentage (%)=treatment back survival chicken number/dispensing
Morbidity chicken number in sickness rate (%)=treatment/dispensing back chicken number * 100
The body weight of every plumage chicken during according to on-test and end, the weightening finish of calculating every plumage chicken.With the weightening finish of normal healthy controls (negative control) group is 100%, and each group weightening finish is compared with the weightening finish of normal healthy controls group, calculates the relative weight gain rate of each group.
After the drug withdrawal three days, the administration experimental chicken did not have tangible clinical symptoms, and the no typical cytopathic of inspection is cutd open in sampling, is judged to healing, and sx, anti-mistake chicken are effective in the therapeutic process.
The grouping of table 1 test chicken and processing (unit: plumage, g)
| Numbering | Group | Quantity | Body weight | Handle |
| 1 2 3 4 5 6 7 | The normal healthy controls group infects the safe control group of dosage group wolf's milk fine powder low dose group wolf's milk medicinal material control group wolf's milk fine powder in the control group wolf's milk fine powder high dose group wolf's milk fine powder | 50 50 50 50 50 50 50 | 88.29±13.77 75.87±13.75 84.95±12.55 87.43±11.83 82.37±13.46 85.53±11.44 83.37±10.38 | Do not infect, not administration is infected, not administration 0.1g/ plumage mixes drink, infect the 0.05g/ plumage and mix drink, infect the 0.025g/ plumage and mix drink, infect 2g/ plumage mixed feeding, infect the 1.0g/ plumage and mix drink, do not infect |
30-35h behind the counteracting toxic substances respectively organizes the full group of chicken and clinical symptoms occurs except that the normal healthy controls group, the performance cardinal symptom is depressed for spirit, appetite descends, the feather pine disorderly, sagging, the lethargy of closing one's eyes of both wings, drop-head stays and stands, draws white or kermesinus loose stool.The visible lung of postmortem is kermesinus, and liver has a large amount of point-like or striated hemorrhage, and there is turbid liquid in the thoracic cavity, and pericardium has the cellulose calmness, and kidney is pale, urate deposition is arranged, and caseous substance is arranged in the caecum.Part night blindness enteral is mixed with blood, and is all separable to a large amount of Pullorum Disease Salmonellas by liver, spleen, lung.The proof experimental chicken is infected chicken Hakuri Salmonella.
Experimental result sees the following form:
The smart powder of table 2 Herba Euphorbiae Humifusae is to the efficacy result of the white scour of chicken
| Numbering | Group | Death toll | Mortality rate | Cure rate | Average weight | The relative weight gain rate |
| 1 2 3 4 5 6 | Normal healthy controls infects the smart powder low dosage of dosage Herba Euphorbiae Humifusae Herba Euphorbiae Humifusae medical material contrast in the smart powder of the smart powder high dose of contrast Herba Euphorbiae Humifusae Herba Euphorbiae Humifusae | 0 22 0 2 6 15 | 0 44 0 4 12 30 | 100 94 84 66 | 304.86 214.04 289.18 282.78 254.54 235.19 | 100 63.8 94.3 90.2 79.5 70.1 |
Statistical results show, smart basic, normal, high dosage group of powder of Herba Euphorbiae Humifusae and Herba Euphorbiae Humifusae medical material group mortality rate all extremely significantly are lower than infection matched group (P＜0.01).The cure rate utmost point is significantly higher than and infects matched group (P＜0.01), illustrates that smart powder of Herba Euphorbiae Humifusae and Herba Euphorbiae Humifusae medical material have curative effect preferably to white diarrhea disease.The mortality rate and the cure rate of smart basic, normal, high dosage group of powder of Herba Euphorbiae Humifusae and Herba Euphorbiae Humifusae medical material group comparison shows that best with the smart powder group of middle and high dosage Herba Euphorbiae Humifusae, its mortality rate extremely significantly is lower than smart powder group of low dosage Herba Euphorbiae Humifusae and Herba Euphorbiae Humifusae medical material group (P＜0.01); The smart powder of proof Herba Euphorbiae Humifusae has certain therapeutic effect to the treatment white diarrhea disease, and is best with the therapeutic effect of the smart powder of middle and high dosage Herba Euphorbiae Humifusae especially.
Confirmed the purposes of the smart powder of Herba Euphorbiae Humifusae on the treatment livestock and poultry pestilence.Since process using water extraction of the present invention, the method for sour earlier back alkali, water temperature raising degree is higher, has kept the effective ingredient in the medicine, and the active component in the smart powder has overcome the difficult difficulty that absorbs of Herba Euphorbiae Humifusae crude drug.After water is carried, do not adopt alcohol deposition method, kept the nutritions such as protein in the medicine, after poultry are taken in, help the growth of poultry, thereby improved the economic benefit of culturing, reduced the medicine production cost.Generally speaking reduced aquaculture cost, solved because of Resistant strain exists and used the inoperative difficulty of antibiotic therapy.Be used for the treatment of domestic animal, poultry because of the infectiousness eqpidemic disease has excellent curative, played the effect of heat-clearing and toxic substances removing, cooling blood for hemostasis.
Above-mentioned method for making has been broken the traditional human Chinese medicine secondary neutral water extraction or the method for decocting in water precipitate with ethanol, leaching process adopts partly bionical---sour earlier back alkaline extraction, the effective ingredient that has farthest kept Herba Euphorbiae Humifusae, be particularly suitable for the poultry medication, in leaching process, do not use organic solvent, reduced the step that also will extract organic solvent, avoided the organic solvent residue problem with behind the organic solvent extraction.Protect the effective ingredient in the medicine to greatest extent, reduced production cost.
The invention has the beneficial effects as follows: by zoopery, confirmed the smart treated powder domestic animal of Herba Euphorbiae Humifusae, poultry, played the effect of heat-clearing and toxic substances removing, cooling blood for hemostasis because of the pestilent toxicity eqpidemic disease that infection pathogen causes has excellent curative.
The specific embodiment:
Embodiment 1: get Herba Euphorbiae Humifusae medical material 100kg, with the Herba Euphorbiae Humifusae raw material wash on request, pick up, cut, dry, pulverized behind 60 orders standby.Extracting temperature is 95 ± 3 ℃, and amount of water is 8 times of medical material weight for the first time, the acid for adjusting pH to 3 with 10%, and extraction time is 2 hours; For the second time amount of water still be 8 times of medical material weight, and with 10% alkali adjusting pH to 8.5, extraction time is 1 hour.80 ℃ of thickening temperatures, vacuum-0.09Mpa, being concentrated into proportion is 1.20g/cm
3(50 ℃).Spray drying or vacuum decompression crushed after being dried promptly get the smart powder 16.6kg (yield is 16.6%) of Herba Euphorbiae Humifusae.
Owner of the present invention will be used for the control of Pullorum Disease, avian typhoid, fowl cholera, colibacillosis, gangrenosum acne enteritis.Adopt medicine of the present invention, 100g converts water 100kg, freely drinks water logotype 3～5 days.
Embodiment 2: get Herba Euphorbiae Humifusae medical material 100kg, method for making is with embodiment 1.Can get the smart powder 17.5kg (yield is 17.5%) of Herba Euphorbiae Humifusae after the extraction.Owner of the present invention will be used for the control of eqpidemic diseases such as pig lung plague, yellow and white dysentery of piglet, bowel oedema disease, swine dysentery.Adopt medicine of the present invention, 1g/kg feedstuff mixed feeding, free choice feeding, logotype 3～5 days.
Claims (3)
1, a kind of have heat-clearing and toxic substances removing, a blood cooling and hemostatic functions animal medicament, it is characterized in that being is the medicament that raw material is made by Herba Euphorbiae Humifusae
Dose processing method: Herba Euphorbiae Humifusae is removed impurity afterwash, cutting, grind then, cross 60 mesh sieves, standby; At first the Herba Euphorbiae Humifusae after handling is extracted: with the water extraction of 8 times of amounts of medical material, extracting temperature is 95 ± 3 ℃, and being adjusted to pH with 10% acid for the first time is 2-5, decocts 2 hours; Extract for the second time 8 times that will water add to medical material weight, regulating pH with 10% alkali is 8-9, and extraction time is 1.5 hours, and medicinal liquid filters the back merging respectively, and filtrate is concentrated into relative density and is about 1.34-1.36g/cm
370 ℃ thick paste, thick paste carries out vacuum drying, pulverizes; Or filtrate to be concentrated into relative density be 1.10-1.20g/cm
370 ℃ clear paste, spray drying promptly get the smart powder of Herba Euphorbiae Humifusae, and yield is 13.2%-19.8%.
2, a kind of method for making with animal medicament of heat-clearing and toxic substances removing, blood cooling and hemostatic functions, comprise the Herba Euphorbiae Humifusae medical material is removed impurity afterwash, cutting, grind then, cross 60 mesh sieves, standby, it is characterized in that at first the Herba Euphorbiae Humifusae after handling being extracted: with the water extraction of 8 times of amounts of medical material, extracting temperature is 95 ± 3 ℃, for the first time being adjusted to pH with 10% acid is 2-5, decocts 2 hours; Extract for the second time 8 times that will water add to medical material weight, pH is 8-9 with the adjusting of 10% alkali, and extraction time is 1.5 hours; Medicinal liquid filters the back respectively and merges, and promptly gets the Herba Euphorbiae Humifusae extracting solution, and the Herba Euphorbiae Humifusae extracting solution is concentrated into relative density and is about 1.34-1.36g/cm
370 ℃ thick paste, thick paste carries out vacuum drying, pulverizes; Or filtrate to be concentrated into relative density be 1.10-1.20g/cm
370 ℃ clear paste, spray drying promptly get the smart powder of Herba Euphorbiae Humifusae, and yield is 13.2%-19.8%.
3, describedly have heat-clearing and toxic substances removing, blood cooling and hemostatic functions animal medicament and a method for making thereof according to claim 1 and 2, it is characterized in that described acid is hydrochloric acid or lactic acid; Alkali is to regulate pH value with sodium hydroxide.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200510015056 CN1927254A (en) | 2005-09-09 | 2005-09-09 | Medicament for animals with heat clearing and detoxicating, blood cooling and hemostatic functions and preparing method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510015056 CN1927254A (en) | 2005-09-09 | 2005-09-09 | Medicament for animals with heat clearing and detoxicating, blood cooling and hemostatic functions and preparing method thereof |
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| CN1927254A true CN1927254A (en) | 2007-03-14 |
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| CN 200510015056 Pending CN1927254A (en) | 2005-09-09 | 2005-09-09 | Medicament for animals with heat clearing and detoxicating, blood cooling and hemostatic functions and preparing method thereof |
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