CN1935163A - Animal medicament with expelling toxin by cooling and cooling blood to stop diarrhea and its preparing method - Google Patents
Animal medicament with expelling toxin by cooling and cooling blood to stop diarrhea and its preparing method Download PDFInfo
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- CN1935163A CN1935163A CNA2005100151159A CN200510015115A CN1935163A CN 1935163 A CN1935163 A CN 1935163A CN A2005100151159 A CNA2005100151159 A CN A2005100151159A CN 200510015115 A CN200510015115 A CN 200510015115A CN 1935163 A CN1935163 A CN 1935163A
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Abstract
The present invention relates to an animal medicine preparation with the functions of clearing away heat and toxic material, cooling blood and relieving dysentery for curing animal disease. Said animal medicine preparation is made up by using Chinese medicinal material portulaca through a certain preparation process. Said invention also provides the concrete steps of said preparation process.
Description
Technical field
The present invention relates to derive from the technical field of medicinal preparation (international Patent classificating number 35/79) of the product that contains not clear structure of plant, specifically is the animal medicament and the method for making thereof of a kind of heat-clearing and toxic substances removing of feedstock production, eliminating pathogenic heat from blood to cure dysentery function with the Chinese crude drug Herba Portulacae.
Background technology
Chinese medicine and pharmacy is one of important component part in the cultural treasure-house of China's medicine, and Chinese herbal medicine then is the culture rarity of China.Aspect animal medicine, traditional Chinese veterinary medicine is also playing crucial effect aspect the Clinics and Practices of livestock and poultry.
(the different name HERBA PORTULACAE comes from Lei Gong's Treatise on Preparation and Broiling of Materia Medica to Herba Portulacae; Five FANGCAO, long life dish, Herba Peristrophes dish come from " detailed outline "; Horse Serpentis dish, Formica fusca dish come from " the northeast medicine is planted will "; Horse steps on dish, comes from " Shandong Chinese medicine ") be one of heat-clearing and toxic substances removing the most frequently used in the Chinese medicine for animals, eliminating pathogenic heat from blood to cure dysentery medical material.2000 editions veterinary drug allusion quotations are recorded its medical material and are used for poultry pyretic toxicity dysentery, skin ulcer general edema with yellowish skin poison, pyretic stranguria hematuria, disease such as have blood in stool, be used for diseases such as fish enteritis, scale erection simultaneously, its main usage is that pulverizing medicinal materials becomes last and feeds, and consumption is bigger than normal, and main cause is that medicine just excretes in the body without absorbing in vivo, birds particularly, because of its distinctive intestinal short, can not digest cellulose etc. physiological characteristics, cause a large amount of medical material wastes.
In clinical use; because modern large-scale cultivation; directly the Chinese medicine crude drug is carried out the mixed feeding administration and usually cause problems such as administration inconvenience, abnormal smells from the patient is dense, absorbance is low; make the Herba Portulacae drug effect not bring into play fully; and common extraction method is to adopt common decocting in water precipitate with ethanol to extract; not only waste a large amount of ethanol, also lost the mass efficient composition simultaneously.Do not retrieve at present the application of the smart powder of Herba Portulacae on livestock and poultry pestilence as yet, the extractive technique of Herba Portulacae usually is the extractive technique of human medicine, and technical sophistication, cost height are used for poultry medication and uneconomical; And the said extracted process usually can be removed the nutritional labelings such as protein in the Chinese medicine, and this has improved aquaculture cost virtually again for livestock and poultry cultivation.
Summary of the invention
Purpose of the present invention is exactly for a kind of smart powder preparation of Herba Portulacae for animals with functions such as heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery is provided.Be used to cure mainly the animal dysentery, the intestinal Huang is had blood in stool, hematuria, and hemoptysis, injury from falling down, the carbuncle malignant boil be used for diseases such as fish enteritis, gill rot simultaneously, but mixed feeding also can be mixed the drink administration, simultaneously again can be as the raw material of further preparation.The chemical drugs therapy is generally adopted in bacillary, the viral infection of treatment domestic animal at present, heavy dose of chemical drugs that feeds also makes the intravital normal flora of machine suffer to destroy and imbalance in the treatment disease, causes producing in the body residual in animal foodstuff of Resistant strain and medicine.Herba Portulacae property suffering, flat is gone into liver, large intestine channel, and multiple pathogenic coccus and bacillus are had tangible bacteriostasis.And the present invention---the digestive system infection that the smart powder of Herba Portulacae causes for virus can comparatively fast be eliminated symptom, promotes body recovery.The smart powder side effect of Herba Portulacae is little, the no obvious toxic and side effects in oral back, and do not produce drug resistance after using, body is interior without any drug residue.
It is comparatively simple that another object of the present invention just provides a kind of extracting method, is used for the lower-cost a kind of method for making with animal medicament of heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery function of the treatment of livestock and poultry pestilence.
The invention provides a kind of have heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery function animal medicament in order to reach the foregoing invention purpose, it is characterized in that this medicament is is the medicament that raw material is made by Herba Portulacae.
Dose processing method: Herba Portulacae is removed impurity afterwash, cutting, grind then, cross 60 mesh sieves, standby; At first the Herba Portulacae after handling is extracted: with the water extraction of 8 times of amounts of medical material, extracting temperature is 95 ± 3 ℃, and being adjusted to pH with 10% acid for the first time is 2-5, decocts 2 hours; Extract for the second time 8 times that will water add to medical material weight, regulating pH with 10% alkali is 8-9, and extraction time is 1.5 hours, and medicinal liquid filters the back merging respectively, and filtrate is concentrated into relative density and is about 1.34-1.36g/cm
3, 70 ℃ thick paste, thick paste carries out vacuum drying, pulverizes; Or merging rear filtrate, to be concentrated into relative density be 1.10-1.20g/cm
3Clear paste, spray drying promptly gets the smart powder of Herba Portulacae, yield is 13.7%-19.9%.
A kind of method for making with animal medicament of heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery function, comprise the Herba Portulacae medical material is removed impurity afterwash, cutting, grind then, cross 60 mesh sieves, standby, it is characterized in that at first the Herba Portulacae after handling being extracted: with the water extraction of 8 times of amounts of medical material, extracting temperature is 95 ± 3 ℃, for the first time being adjusted to pH with 10% acid is 2-5, decocts 2 hours; Extract for the second time 8 times that will water add to medical material weight, pH is 8-9 with the adjusting of 10% alkali, and extraction time is 1.5 hours; Medicinal liquid filters the back respectively and merges, and promptly gets Herba Portulacae extract, and Herba Portulacae extract is concentrated into relative density and is about 1.34-1.36g/cm
3, 70 ℃ thick paste, thick paste carries out vacuum drying, pulverizes; Or Herba Portulacae extract to be concentrated into relative density be 1.10-1.20g/cm
3Clear paste, spray drying promptly gets the smart powder (yield is 13.7%-19.9%) of Herba Portulacae.
Have heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery function animal medicament and a method for making thereof according to described, it is characterized in that described acid is with hydrochloric acid or lactic acid; Alkali is to regulate pH value with sodium hydroxide.
Finished product of the present invention can be made multiple dosage form as required, adds appropriate amount of auxiliary materials and can be used as injection, is used for intramuscular injection; Directly medicinal can mixed feeding or mix drink; Carry out breast or intestinal perfusion after also can be water-soluble with powder.
It is respond well to confirm that by experiment this medicine is used for the treatment of Pullorum Disease, and experimental result is as follows:
The experiment medicine: the smart powder of Herba Portulacae, control drug is that the Herba Portulacae decoction pieces is made the Herba Portulacae powder after crushed.
Laboratory animal: 15 350 of age in days Ai Wei mattress broiler (providing) by the chicken farm, Tianjin, the sealing chicken coop is raised, and the complete feed of feeding is freely drunk water.
Seed culture of viruses: the Pullorum Disease Salmonella is that microorganism teaching and research room provides by the TanJin Agricultural College animal science.
Experimental technique: laboratory animal is divided into 7 groups at random, and first group is the normal healthy controls group, does not infect not administration; Second group for infecting matched group, infection, not administration; The 3rd group is the smart powder high dose group of Herba Portulacae, infects 0.2g/ chicken back every day, logotype 5 days; The 4th group is dosage group in the smart powder of Herba Portulacae, infects 0.1g/ chicken back every day, logotype 5 days; The 5th group is the smart powder low dose group of Herba Portulacae, infects 0.05g/ chicken back every day, logotype 5 days; The 6th group is Herba Portulacae medical material matched group, infects 3g/ chicken back every day, logotype 5 days; The 7th group is the smart powder safe dose of Herba Portulacae group, do not infect, every day 2g/ chicken, logotype 5 days.
Experimental session, every day, observed and recorded was added up effective percentage, mortality rate and the relative weight gain rate after the course of treatment.
Chicken number * 100 before effective percentage (%)=treatment back survival chicken number/dispensing
Morbidity chicken number in sickness rate (%)=treatment/dispensing back chicken number * 100
The body weight of every plumage chicken during according to on-test and end, the weightening finish of calculating every plumage chicken.With the weightening finish of normal healthy controls (negative control) group is 100%, and each group weightening finish is compared with the weightening finish of normal healthy controls group, calculates the relative weight gain rate of each group.
After the drug withdrawal three days, the administration experimental chicken did not have tangible clinical symptoms, and the no typical cytopathic of inspection is cutd open in sampling, is judged to healing, and sx, anti-mistake chicken are effective in the therapeutic process.
The grouping of table 1 test chicken and processing
| Numbering | Group | Quantity (only) | Body weight (g) | Handle |
| 1 2 3 4 5 6 7 | The normal healthy controls group infects the safe control group of dosage group purslane fine powder low dose group purslane medicinal material control group purslane fine powder in the control group purslane fine powder high dose group purslane fine powder | 50 50 50 50 50 50 50 | 91.33±15.24 90.56±12.79 90.96±13.25 89.49±14.66 88.59±14.24 92.13±13.15 92.78±11.91 | Do not infect, not administration is infected, not administration 0.2g/ plumage mixes drink, infect the 0.1g/ plumage and mix drink, infect the 0.05g/ plumage and mix drink, infect 3g/ plumage mixed feeding, infect the 2.0g/ plumage and mix drink, do not infect |
30-35h behind the counteracting toxic substances respectively organizes the full group of chicken and clinical symptoms occurs except that the normal healthy controls group, the performance cardinal symptom is depressed for spirit, appetite descends, the feather pine disorderly, sagging, the lethargy of closing one's eyes of both wings, drop-head stays and stands, draws white or kermesinus loose stool.The visible lung of postmortem is kermesinus, and liver has a large amount of point-like or striated hemorrhage, and there is turbid liquid in the thoracic cavity, and pericardium has the cellulose calmness, and kidney is pale, urate deposition is arranged, and caseous substance is arranged in the caecum.Part night blindness enteral is mixed with blood, and is all separable to a large amount of Pullorum Disease Salmonellas by liver, spleen, lung.The proof experimental chicken is infected chicken Hakuri Salmonella.
Experimental result sees the following form:
The smart powder of table 2 Herba Portulacae is to the efficacy result of the white scour of chicken
| Numbering | Group | Death toll (only) | Mortality rate (%) | Cure rate (%) | Average weight (only) | The relative weight gain rate (%) |
| 1 2 3 4 5 6 | Normal healthy controls infects the smart powder low dosage of dosage Herba Portulacae Herba Portulacae medical material contrast in the smart powder of the smart powder high dose of contrast Herba Portulacae Herba Portulacae | 0 22 1 3 5 14 | 0 44 2 6 10 28 | 98 94 82 68 | 311.55 226.44 297.31 287.25 257.50 235.19 | 100 61.7 93.7 89.8 76.7 70.5 |
Statistical results show, smart basic, normal, high dosage group of powder of Herba Portulacae and Herba Portulacae medical material group mortality rate all extremely significantly are lower than infection matched group (P＜0.01).The cure rate utmost point is significantly higher than and infects matched group (P＜0.01), illustrates that smart powder of Herba Portulacae and Herba Portulacae medical material have curative effect preferably to white diarrhea disease.The mortality rate and the cure rate of smart basic, normal, high dosage group of powder of Herba Portulacae and Herba Portulacae medical material group comparison shows that best with the smart powder group of middle and high dosage Herba Portulacae, its mortality rate extremely significantly is lower than smart powder group of low dosage Herba Portulacae and Herba Portulacae medical material group (P＜0.01); The smart powder of proof Herba Portulacae has certain therapeutic effect to the treatment white diarrhea disease, and is best with the therapeutic effect of the smart powder of middle and high dosage Herba Portulacae especially.
Confirmed the purposes of the smart powder of Herba Portulacae on the treatment livestock and poultry pestilence.Since process using water extraction of the present invention, the method for sour earlier back alkali, water temperature raising degree is higher, has kept the effective ingredient in the medicine, and the active component in the smart powder has overcome the difficult difficulty that absorbs of Herba Portulacae crude drug.After water is carried, do not adopt alcohol deposition method, kept the nutritions such as protein in the medicine, after poultry are taken in, help the growth of poultry, thereby improved the economic benefit of culturing, reduced the medicine production cost.Generally speaking reduced aquaculture cost, solved because of Resistant strain exists and used the inoperative difficulty of antibiotic therapy.Be used for the treatment of domestic animal, poultry because of the infectiousness eqpidemic disease has excellent curative, played the effect of heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery.
Above-mentioned method for making has been broken the traditional human Chinese medicine secondary neutral water extraction or the method for decocting in water precipitate with ethanol, leaching process adopts partly bionical---sour earlier back alkaline extraction, the effective ingredient that has farthest kept Herba Portulacae, be particularly suitable for the poultry medication, in leaching process, do not use organic solvent, reduced the step that also will extract organic solvent, avoided the organic solvent residue problem with behind the organic solvent extraction.Protect the effective ingredient in the medicine to greatest extent, reduced production cost.
The invention has the beneficial effects as follows: by zoopery, confirmed the smart treated powder domestic animal of Herba Portulacae, poultry, played the effect of heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery because of the pestilent toxicity eqpidemic disease that infection pathogen causes has excellent curative.
The specific embodiment:
Embodiment 1: get Herba Portulacae medical material 100kg, with the Herba Portulacae raw material wash on request, pick up, cut, dry, pulverized behind 60 orders standby.Extracting temperature is 95 ± 3 ℃, and amount of water is 8 times of medical material weight for the first time, the acid for adjusting pH to 3 with 10%, and extraction time is 2 hours; For the second time amount of water still be 8 times of medical material weight, and with 10% alkali adjusting pH to 8.5, extraction time is 1 hour.80 ℃ of thickening temperatures, vacuum-0.09Mpa, being concentrated into proportion is 1.20g/cm
3(50 ℃).Spray drying or vacuum decompression crushed after being dried promptly get the smart powder 16.6kg (yield is 16.6%) of Herba Portulacae.
Owner of the present invention will be used for the control of pestilence such as Pullorum Disease, avian typhoid, fowl cholera, colibacillosis, necrotic enteritis.Adopt medicine of the present invention, every day, the 0.15g/ plumage was freely drunk water, logotype 3～5 days.
Embodiment 2: get Herba Portulacae medical material 100kg, method for making is with embodiment 1.Can get the smart powder 17.5kg (yield is 17.5%) of Herba Portulacae after the extraction.Owner of the present invention will be used for the control of pestilence such as pig lung plague, yellow and white dysentery of piglet, bowel oedema disease, swine dysentery.Adopt medicine of the present invention, by 0.05g/kg body weight consumption adding every day feedstuff mixed feeding, free choice feeding, logotype 3～5 days.
Claims (3)
1, a kind of have heat-clearing and toxic substances removing, an eliminating pathogenic heat from blood to cure dysentery function animal medicament, it is characterized in that being is the medicament that raw material is made by Herba Portulacae
Dose processing method: Herba Portulacae is removed impurity afterwash, cutting, grind then, cross 60 mesh sieves, standby; At first the Herba Portulacae after handling is extracted: with the water extraction of 8 times of amounts of medical material, extracting temperature is 95 ± 3 ℃, and being adjusted to pH with 10% acid for the first time is 2-5, decocts 2 hours; Extract for the second time 8 times that will water add to medical material weight, regulating pH with 10% alkali is 8-9, and extraction time is 1.5 hours, and medicinal liquid filters the back merging respectively, and filtrate is concentrated into relative density and is about 1.34-1.36g/cm
3, 70 ℃ thick paste, thick paste carries out vacuum drying, pulverizes; Or filtrate to be concentrated into relative density be 1.10-1.20g/cm
3, 70 ℃ clear paste, spray drying promptly gets the smart powder of Herba Portulacae, and yield is 13.7%-19.9%.
2, a kind of method for making with animal medicament of heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery function, comprise the Herba Portulacae medical material is removed impurity afterwash, cutting, grind then, cross 60 mesh sieves, standby, it is characterized in that at first the Herba Portulacae after handling being extracted: with the water extraction of 8 times of amounts of medical material, extracting temperature is 95 ± 3 ℃, for the first time being adjusted to pH with 10% acid is 2-5, decocts 2 hours; Extract for the second time 8 times that will water add to medical material weight, pH is 8-9 with the adjusting of 10% alkali, and extraction time is 1.5 hours; Medicinal liquid filters the back respectively and merges, and promptly gets Herba Portulacae extract, and Herba Portulacae extract is concentrated into relative density and is about 1.34-1.36g/cm
3, 70 ℃ thick paste, thick paste carries out vacuum drying, pulverizes; Or filtrate to be concentrated into relative density be 1.10-1.20g/cm
3, 70 ℃ clear paste, spray drying promptly gets the smart powder of Herba Portulacae, and yield is 13.7%-19.9%.
3, describedly have heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery function animal medicament and a method for making thereof according to claim 1 and 2, it is characterized in that described acid is with hydrochloric acid or lactic acid; Alkali is to regulate pH value with sodium hydroxide.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2005100151159A CN1935163A (en) | 2005-09-20 | 2005-09-20 | Animal medicament with expelling toxin by cooling and cooling blood to stop diarrhea and its preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2005100151159A CN1935163A (en) | 2005-09-20 | 2005-09-20 | Animal medicament with expelling toxin by cooling and cooling blood to stop diarrhea and its preparing method |
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| Publication Number | Publication Date |
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| CN1935163A true CN1935163A (en) | 2007-03-28 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2005100151159A Pending CN1935163A (en) | 2005-09-20 | 2005-09-20 | Animal medicament with expelling toxin by cooling and cooling blood to stop diarrhea and its preparing method |
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| CN (1) | CN1935163A (en) |
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- 2005-09-20 CN CNA2005100151159A patent/CN1935163A/en active Pending
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