CN1939440A - Animal medicament with anthemorrhagic toxin-removing and dysentery-eliminating functions and its preparation - Google Patents
Animal medicament with anthemorrhagic toxin-removing and dysentery-eliminating functions and its preparation Download PDFInfo
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- CN1939440A CN1939440A CN 200510015181 CN200510015181A CN1939440A CN 1939440 A CN1939440 A CN 1939440A CN 200510015181 CN200510015181 CN 200510015181 CN 200510015181 A CN200510015181 A CN 200510015181A CN 1939440 A CN1939440 A CN 1939440A
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Abstract
A veterinary medicine with the functions of stypsis, haemostasis, treating dycentery and detoxication for treating the epidemic diseases of domestic animals and fowls is prepared from grinony root through pre-treating, decocting in water for 2 hr while using acid to regulate pH=2-5, filtering, decocting again for 1.5 hr while using alkali to regulate pH=8-9, filtering, collecting the decoction, drying and pulverizing.
Description
Technical field
The present invention relates to derive from the technical field of medicinal preparation (international Patent classificating number 35/79) of the product that contains not clear structure of plant, specifically is the animal medicament and the method for making thereof of a kind of astringing to arrest bleeding of feedstock production, dysentery relieving function of detoxification with the Chinese crude drug Herba Agrimoniae.
Background technology
Chinese medicine and pharmacy is one of important component part in the cultural treasure-house of China's medicine, and Chinese herbal medicine then is the culture rarity of China.Aspect animal medicine, traditional Chinese veterinary medicine is also playing crucial effect aspect the Clinics and Practices of livestock and poultry.
(the different name Radix Agrimoniae is executed the state Radix Agrimoniae to Herba Agrimoniae, comes from " Bencao Tujing "; The melon Rhizoma et radix valerianae is come from herbal for Relief of Famines) be one of detoxifcation dysentery relieving medical material commonly used in the Chinese medicine for animals, its pharmacological action of modern study: water decoction has antiinflammatory and antiparasitic effect.2000 editions veterinary drug allusion quotations are recorded its medical material and are used for the treatment of diseases such as poultry are had blood in stool, hematuria, haematemesis, dysentery, carbuncle sore tumefacting virus.
In clinical use; because modern large-scale cultivation; directly the Chinese medicine crude drug is carried out the mixed feeding administration and usually cause problems such as administration inconvenience, abnormal smells from the patient is dense, absorbance is low; make the Herba Agrimoniae drug effect not bring into play fully; and extract as the decocting in water alcohol deposition method that Pharmacopoeia of the People's Republic of China of version in 2005 " compound agrimony enteritis capsule " preparation is taked to use always; not only lose the mass efficient composition, also wasted a large amount of ethanol simultaneously.Do not retrieve at present the application of the smart powder of Herba Agrimoniae on livestock and poultry pestilence as yet, Herba Agrimoniae is mainly used to treat hemoptysis, haematemesis, carbuncle sore tumefacting virus on human, extractive technique also is the extractive technique of human medicine, and technical sophistication, cost height are used for poultry medication and uneconomical; And the said extracted process usually can be removed the nutritional labelings such as protein in the Chinese medicine, and this has improved aquaculture cost virtually again for livestock and poultry cultivation.
Summary of the invention
The objective of the invention is for a kind of smart powder preparation of Herba Agrimoniae with functions such as astringing to arrest bleeding, dysentery relieving detoxifcations is provided.Be used to cure mainly diseases such as poultry are had blood in stool, hematuria, haematemesis, dysentery, carbuncle sore tumefacting virus, but mixed feeding also can be mixed the drink administration, simultaneously again can be as the raw material of further preparation.Antibiotherapy is generally adopted in bacillary, the viral infection of treatment domestic animal at present, heavy dose of antibiotic that feeds also makes the intravital normal flora of machine suffer to destroy and imbalance in the treatment disease, causes producing in the body residual in animal foodstuff of Resistant strain and medicine.Herba Agrimoniae nature and flavor hardship, puckery, flat can be gone into the heart, Liver Channel, and pathogenic bacterias such as staphylococcus aureus, tubercule bacillus are had certain inhibitory action.And the present invention---the smart powder of Herba Agrimoniae can be eliminated symptom quickly for diseases such as having blood in stool of being caused by a variety of causes, hematuria, anemias, promotes body recovery.The smart powder side effect of Herba Agrimoniae is little, the no obvious toxic and side effects in oral back, and do not produce drug resistance after using, body is interior without any drug residue.
It is comparatively simple that another object of the present invention just provides a kind of extracting method, is used for the lower-cost a kind of method for making with animal medicament of astringing to arrest bleeding, dysentery relieving function of detoxification of the treatment of livestock and poultry pestilence.
The invention provides a kind of animal medicament in order to reach the foregoing invention purpose, it is characterized in that this medicament is is the medicament that raw material is made by Herba Agrimoniae with astringing to arrest bleeding, dysentery relieving function of detoxification.
Dose processing method: Herba Agrimoniae is removed impurity afterwash, cutting, grind then, cross 60 mesh sieves, standby; At first the Herba Agrimoniae after handling is extracted: with the water extraction of 8 times of amounts of medical material, extracting temperature is 95 ± 3 ℃, and being adjusted to pH with 10% acid for the first time is 2-5, decocts 2 hours; Extract for the second time 8 times that will water add to medical material weight, regulating pH with 10% alkali is 8-9, and extraction time is 1.5 hours, and medicinal liquid filters the back merging respectively, and filtrate is concentrated into relative density and is about 1.34-1.36g/cm
3, 70 ℃ thick paste, thick paste carries out vacuum drying, pulverizes; Or merging rear filtrate, to be concentrated into relative density be 1.10-1.20g/cm
3, 70 ℃ clear paste is pulverized promptly after the spray drying; Yield is 13.4%-20.1%.
A kind of method for making with animal medicament of astringing to arrest bleeding, dysentery relieving function of detoxification, comprise the Herba Agrimoniae medical material is removed impurity afterwash, cutting, grind then, cross 60 mesh sieves, standby, it is characterized in that at first the Herba Agrimoniae after handling being extracted: with the water extraction of 8 times of amounts of medical material, extracting temperature is 95 ± 3 ℃, for the first time being adjusted to pH with 10% acid is 2-5, decocts 2 hours; Extract for the second time 8 times that will water add to medical material weight, pH is 8-9 with the adjusting of 10% alkali, and extraction time is 1.5 hours; Medicinal liquid filters the back respectively and merges, and promptly gets the Herba Agrimoniae extracting solution, and the Herba Agrimoniae extracting solution is concentrated into relative density and is about 1.34-1.36g/cm
3, 70 ℃ thick paste, thick paste carries out vacuum drying, pulverizes; Or merging rear filtrate, to be concentrated into relative density be 1.10-1.20g/cm
3, 70 ℃ clear paste is pulverized after the spray drying and is promptly got the smart powder (yield is 13.4%-20.1%) of Herba Agrimoniae.
Have astringing to arrest bleeding, dysentery relieving function of detoxification animal medicament and a method for making thereof according to described, it is characterized in that described acid is with hydrochloric acid or lactic acid; Alkali is to regulate pH value with sodium hydroxide.
Finished product of the present invention can be made multiple dosage form as required, adds appropriate amount of auxiliary materials and can be used as injection, is used for intramuscular injection; Directly medicinal can mixed feeding or mix drink; Carry out intestinal perfusion after also can be water-soluble with powder.
Be the curative effect of checking medicine of the present invention, carry out following experiment the chicken leucocyte protozoon disease:
The experiment medicine: the smart powder of Herba Agrimoniae, control drug is that the Herba Agrimoniae decoction pieces is made Hairyvein Agrimonia Herd after crushed.
Laboratory animal and grouping: test be 350 100 age in days parts in Beijing opera spoken in Beijing dialect healthy chickens available from the big fowl in Tianjin side industry company limited with chicken, checks no cause of disease existence with parasitology inspection technique (venous blood collection smear, dyeing microscopic examination under the wing), promptly can be used as to test and uses chicken.To test with healthy chicken and be divided into 7 groups, 50 every group.Wherein 1,2,3 group is respectively and attacks the high, medium and low dosage treatment group of the smart powder of worm Herba Agrimoniae, 4 groups of Hairyvein Agrimonia Herd treatment matched groups, 5 groups of negative matched groups (attack worm and do not treat matched group), 6 groups of positive matched groups (not attacking the normal healthy controls group that worm is not treated), safe matched group (being used in healthy test chicken) according to the smart powder recommended dose of 10 times of Herba Agrimoniaes.
Experimental technique: 350 of 100 age in days parts in Beijing opera spoken in Beijing dialect healthy chickens are divided into 7 groups, 50 every group at random.Selection detects the sick chicken with typical leucocyte protozoon disease symptoms through the parasitology inspection technique, every 12 milliliters of venous blood collection under wing, give above-mentioned healthy chicken injection (2 milliliters /) (the healthy test chicken except that positive controls and safe matched group) respectively, the clinical manifestation of chicken is noted observing in the injection back, be green, anemia, cockscomb and wattle when pale if inappetence, depressed, the head piece saliva of spirit, dysentery, excrement occur, reuse parasitology inspection technique is made a definite diagnosis, after this therapeutic effect is observed in medication at once.Processing method sees Table 1.
Test chicken begins test after obvious clinical symptoms occurring, wherein 1 group, 2 groups, 3 groups is the smart powder test group of Herba Agrimoniae, press high dose (0.08g/ only mixes drink), middle dosage (0.04g/ only mixes drink), the smart powder of low dosage (0.02g/ only mixes drink) drink-service Herba Agrimoniae respectively, secondary connected and drank 5 days every day.4 groups is the Hairyvein Agrimonia Herd matched group, even drinks 5 days by the dosage (2g/ only) of its description.5 groups of positive contrasts, not medication of counteracting toxic substances.6 groups is blank, counteracting toxic substances not, not medication.7 groups is safe dose matched group (0.8g/ only).After the dispensing, observe the natural law of clinical manifestation transference cure; Dead number of elements; Offer medicine and judge the therapeutic effect of medicine after 3,5,7 days with the positive visual field rate of polypide in the parasitology inspection technique inspection blood.
After the drug withdrawal three days, the administration experimental chicken did not have tangible clinical symptoms, and the no typical cytopathic of inspection is cutd open in sampling, is judged to healing, and sx, anti-mistake chicken are effective in the therapeutic process.
The treatment of table 1 test chicken and grouping
| Group | Test chicken number (only) | Artificial challenge's (ml/ only) | Medicine | Usage | Consumption (g/ only) | The beginning administration time | The medication natural law (my god) |
| 1 group 2 groups 3 groups 4 groups 5 groups 6 groups 7 groups | 50 50 50 50 50 50 50 | 2 2 2 2 2 - | Dosage group hairyvein agrimony fine powder low dose group Hairyvein Agrimonia Herd in the hairyvein agrimony fine powder high dose group hairyvein agrimony fine powder--hairyvein agrimony fine powder safe dose group | Drinking-water drinking-water drinking-water drinking-water--drinking-water | 0.08 0.04 0.02 2 - - 0.8 | Occur behind the artificial challenge at once medication of clinical symptoms the same the same-- | 5 5 7 5 - - 5 |
Behind the counteracting toxic substances behind the 30-35h, respectively organize the full group of chicken and clinical symptoms occurs except that the normal healthy controls group, it is pale to show as dull mind, appetite depression, cockscomb, has loose bowels, and it is dark green that feces mostly is.
Experimental result sees the following form:
The smart powder of table 2 Herba Agrimoniae is lived the therapeutic effect of cell protozoacide to chicken
| Group | The test chicken number | Artificial challenge's sequela number (only) | Main clinical manifestation | Treatment back transference cure natural law (my god) | Dead number of elements (only) | Mortality rate (%) | Cure rate (%) | Polypide disappearance situation after the medication |
| Organize 1 group 2 groups 3 groups 4 groups 5 groups 6 groups 7 | 50 50 50 50 50 50 50 | 50 50 50 50 50 0 | Anaemia is arranged the same no any clinical symptoms of green loose stool and is not had any clinical symptoms | 3357 symptoms do not disappear- | 0 0 4 2 48 0 0 | 0 0 8 4 96 0 | 100 100 92 96 - - | Treat after 5 days polypide disappear treatment after 5 days polypide disappear treatment after 5 days the positive visual field of polypide rate be 5 ‰ treatments after 5 days the positive visual field of polypide rate be that 5 ‰ symptoms occur having no in the polypide process of the test in the blood in rate 736 ‰ processs of the test of the positive visual field of polypide after 5 days and have no polypide in the blood |
As seen from Table 2, the medicine of therapeutic effect the best is the smart powder height of Herba Agrimoniae, middle dosage group, and polypide and cure rate 100% are not seen in medication symptom complete obiteration in 3 days, medication in the blood after 5 days.Though Hairyvein Agrimonia Herd has certain therapeutic effect, compare the smart powder height of Herba Agrimoniae, middle dosage group, effect is comparatively inferior, and therefore, the smart powder of Herba Agrimoniae is the choice drug of treatment chicken leucocyte protozoon disease.By the safety experiment (10 times of amount recommendations are oral, logotype five days) to healthy chicken, the clinical manifestation of no abnormality seen between the operating period illustrates that said preparation does not have obvious influence to healthy chicken, and is safe in utilization simultaneously.
The invention has the beneficial effects as follows: above-mentioned method for making has been broken the traditional human Chinese medicine secondary neutral water extraction or the method for decocting in water precipitate with ethanol, leaching process adopts partly bionical---sour earlier back alkaline extraction, the effective ingredient that has farthest kept Herba Agrimoniae, be particularly suitable for the poultry medication, in leaching process, do not use organic solvent, reduced the step that also will extract organic solvent, avoided the organic solvent residue problem with behind the organic solvent extraction.Protect the effective ingredient in the medicine to greatest extent, reduced production cost.
By zoopery, confirmed that the cell protozoacide of living of the smart treated powder poultry of Herba Agrimoniae has excellent curative, played astringing to arrest bleeding, dysentery relieving antidotal effect.
Confirmed the purposes of the smart powder of Herba Agrimoniae on the treatment livestock and poultry pestilence.Since process using water extraction of the present invention, the method for sour earlier back alkali, water temperature raising degree is higher, has kept the effective ingredient in the medicine, and the active component in the smart powder has overcome the difficult difficulty that absorbs of Herba Agrimoniae crude drug.After water is carried, do not adopt alcohol deposition method, kept the nutritions such as protein in the medicine, after poultry are taken in, help the growth of poultry, thereby improved the economic benefit of culturing, reduced the medicine production cost.Generally speaking reduced aquaculture cost, solved because of Resistant strain exists and used the inoperative difficulty of antibiotic therapy.Be used for the treatment of domestic animal, poultry because of the infectiousness eqpidemic disease has excellent curative, played astringing to arrest bleeding, dysentery relieving antidotal effect.
The specific embodiment:
Embodiment 1: get Herba Agrimoniae medical material 100kg, with the Herba Agrimoniae raw material wash on request, pick up, cut, dry, pulverized behind 60 mesh sieves standby.Extracting temperature is 95 ± 3 ℃, and amount of water is 8 times of medical material weight for the first time, the acid for adjusting pH to 3 with 10%, and extraction time is 2 hours; For the second time amount of water still be 8 times of medical material weight, and with 10% alkali adjusting pH to 8.5, extraction time is 1 hour.80 ℃ of thickening temperatures, vacuum-0.09Mpa, being concentrated into proportion is 1.30g/cm
3(80 ℃).Spray drying or vacuum decompression crushed after being dried promptly get the smart powder 15.2kg (yield is 15.2%) of Herba Agrimoniae.
Certain chicken house chicken group infects the leucocyte protozoon disease, and it is pale that dull mind, appetite depression, cockscomb appear in most of chicken group, has loose bowels, and feces mostly is symptom such as dark green, does not see obvious improvement with antibiotic medicine treatment back effect.Adopt medicine of the present invention, 0.06g/ only/day, freely drink water, carry out five days by a definite date treatment after, most of sick fowl disease close friend commentaries on classics, symptom disappears substantially, cure rate has reached 95%.
Embodiment 2: get Herba Agrimoniae medical material 100kg, method for making is with embodiment 1.Can get the smart powder 16.7kg (yield is 16.7%) of Herba Agrimoniae after the extraction.Certain pig farm piglet infects piglet red dysentery, shows as hemafecia, lassitude, loss of appetite etc., and state of an illness weight differs.In feedstuff, add medicine of the present invention, 0.8g/kg feedstuff, logotype 5 days.Most of sick swine diseases feelings begin to take a turn for the better gradually after 5 days, normal feed of beginning and drinking-water.After continuing to strengthen treatment, be almost recovered.
Claims (3)
1, a kind of animal medicament with astringing to arrest bleeding, dysentery relieving function of detoxification is characterized in that being is the medicament that raw material is made by Herba Agrimoniae
Dose processing method: Herba Agrimoniae is removed impurity afterwash, cutting, grind then, cross 60 mesh sieves, standby; At first the Herba Agrimoniae after handling is extracted: with the water extraction of 8 times of amounts of medical material, extracting temperature is 95 ± 3 ℃, and being adjusted to pH with 10% acid for the first time is 2-5, decocts 2 hours; Extract for the second time 8 times that will water add to medical material weight, regulating pH with 10% alkali is 8-9, and extraction time is 1.5 hours, and medicinal liquid filters the back merging respectively, and filtrate is concentrated into relative density and is about 1.34-1.36g/cm
3, 70 ℃ thick paste, thick paste carries out vacuum drying, pulverizes; Or merging rear filtrate, to be concentrated into relative density be 1.10-1.20g/cm
3, 70 ℃ clear paste is pulverized after the spray drying and is promptly got the smart powder of Herba Agrimoniae, and yield is 13.4%-20.1%.
2, a kind of method for making with animal medicament of astringing to arrest bleeding, dysentery relieving function of detoxification, comprise the Herba Agrimoniae medical material is removed impurity afterwash, cutting, grind then, cross 60 mesh sieves, standby, it is characterized in that at first the Herba Agrimoniae after handling being extracted: with the water extraction of 8 times of amounts of medical material, extracting temperature is 95 ± 3 ℃, for the first time being adjusted to pH with 10% acid is 2-5, decocts 2 hours; Extract for the second time 8 times that will water add to medical material weight, pH is 8-9 with the adjusting of 10% alkali, and extraction time is 1.5 hours; Medicinal liquid filters the back respectively and merges, and promptly gets the Herba Agrimoniae extracting solution, and the Herba Agrimoniae extracting solution is concentrated into relative density and is about 1.34-1.36g/cm
3, 70 ℃ thick paste, thick paste carries out vacuum drying, pulverizes; Or merging rear filtrate, to be concentrated into relative density be 1.10-1.20g/cm
3, 70 ℃ clear paste is pulverized after the spray drying and is promptly got the smart powder of Herba Agrimoniae, and yield is 13.4%-20.1%.
3, describedly have astringing to arrest bleeding, dysentery relieving function of detoxification animal medicament and a method for making thereof according to claim 1 and 2, it is characterized in that described acid is hydrochloric acid or lactic acid; Alkali is to regulate pH value with sodium hydroxide.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104905009A (en) * | 2015-06-29 | 2015-09-16 | 胡凡营 | Plant source feed additive based on environment-friendly feeding of livestock and poultry |
| CN105595037A (en) * | 2015-12-11 | 2016-05-25 | 长顺县昌鹏养殖农民专业合作社 | Feed additive for preventing and treating chicken bloody flux |
-
2005
- 2005-09-26 CN CN 200510015181 patent/CN1939440A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104905009A (en) * | 2015-06-29 | 2015-09-16 | 胡凡营 | Plant source feed additive based on environment-friendly feeding of livestock and poultry |
| CN105595037A (en) * | 2015-12-11 | 2016-05-25 | 长顺县昌鹏养殖农民专业合作社 | Feed additive for preventing and treating chicken bloody flux |
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