CN1939401A - Animal medicament with liverfire-clearing and digesting functions and its making method - Google Patents
Animal medicament with liverfire-clearing and digesting functions and its making method Download PDFInfo
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- CN1939401A CN1939401A CN 200510015180 CN200510015180A CN1939401A CN 1939401 A CN1939401 A CN 1939401A CN 200510015180 CN200510015180 CN 200510015180 CN 200510015180 A CN200510015180 A CN 200510015180A CN 1939401 A CN1939401 A CN 1939401A
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Abstract
A veterinary medicine with the functions of clearing liver fire and eliminating depression for treating the epidemic diseases of domestic animals and fowls is prepared from prunella spike through pre-treating, decocting in water for 2 hr while using acid to regulate pH=2-5, filtering, decocting again for 1.5 hr while using alkali to regulate pH=8-9, filtering, collecting the decoction, drying and pulverizing.
Description
Technical field
The present invention relates to derive from the technical field of medicinal preparation (international Patent classificating number 35/79) of the product that contains not clear structure of plant, specifically is the animal medicament and the method for making thereof of a kind of clearing away liver-fire of feedstock production, Disperse hepatic depression function with the Chinese crude drug Spica Prunellae.
Background technology
Along with the raising of development of productivity, people's living standard, everybody is also more and more higher to the requirement of animal food.Yet drug residue in the animal foodstuff exceeds standard becomes a serious problem at present.European Union successively was emitted in the feedstuff in 1997～2000 years and prohibits, limits the use of chemical synthetic drug, hormone and antibiotic decree; China also adds medicine to feedstuff thereupon and has made relevant limit taboo decree.What use is made of animal health product and herbal medicine carry out the control of animal epidemic and promote the production function and the substituted chemistry medicine is day by day brought into schedule.Yet Chinese crude drug is simply pulverized directly oral medication disease of back mostly at present, though method is simple, but absorb rate variance, most of effective ingredient can not be absorbed fully, has improved cost virtually, wasted valuable Chinese material medicine resource, and if adopt the extracting method of human medicine, though extraction ratio is higher, the method complexity, the cost height, it is very uneconomical to be applied to livestock and poultry pestilence.Do not retrieve at present the application of the smart powder of Spica Prunellae on livestock and poultry pestilence as yet.Spica Prunellae aspect the human medicine mainly be function be relieve inflammation or internal heat, make eye bright, eliminating stagnation, detumescence, be used for that conjunctival congestion and swelling pain, headache are dizzy, thyromegaly, hypertension.The extracting method of existing Spica Prunellae mainly is the extracting method of human preparation simultaneously.The extracting method that " Spica Prunellae cream " is adopted in 2000 editions Pharmacopoeias of the People's Republic of China is simple decocting method, and this extracting method has removed the required nutritional labeling of poultry such as protein in the medicine, has improved the cost of livestock and poultry cultivation virtually.Modern pharmacological research: the Spica Prunellae water decoction has blood pressure lowering, antimicrobial effect, and staphylococcus, dysentery bacterium, bacillus pyocyaneus etc. are had inhibitory action.About the relevant patent of utilizing Chinese medicine extract treatment livestock and poultry pestilence, Chinese invention patent application 03143977.2 once disclosed from Radix Sophorae Flavescentis and had extracted with extract total alkaloids with reuse chloroform behind ethanol, the ether extraction, was used for the treatment of a kind of herbal medicine of domestic animals and fowls bacterial disease.Content from this invention, in leaching process to this medicine, used organic solvent is more, can be in the process of extracting because of the organic solvent residue that causes not in place of some technology, influence the curative effect of medicine, the extracting method that uses of this patent is comparatively complicated simultaneously, is used for the treatment cost of livestock and poultry pestilence higherly, can improve the cost of livestock and poultry cultivation relatively.
Summary of the invention
Purpose of the present invention is exactly for a kind of smart powder preparation of Spica Prunellae for animals with clearing away liver-fire, Disperse hepatic depression function is provided.Be used for the treatment of diseases such as poultry conjunctival congestion and swelling pain, acute mastitis, but mixed feeding also can be mixed the drink administration, simultaneously again can be as the raw material of further preparation.Therefrom veterinary angle is set out, and adopts Chinese medicine preparation to be used for the treatment of livestock and poultry pestilence, and evident in efficacy, cost is low, and drug residue free, the effect that reaching takes stopgap measures effects a permanent cure.
It is comparatively simple that another object of the present invention just provides a kind of extracting method, is used for the lower-cost a kind of method for making with animal medicament of clearing away liver-fire, Disperse hepatic depression function of the treatment of livestock and poultry pestilence.
The invention provides a kind of animal medicament in order to reach the foregoing invention purpose, it is characterized in that this medicament is is the medicament that raw material is made by Spica Prunellae with clearing away liver-fire, Disperse hepatic depression function.
Dose processing method: the Spica Prunellae medical material is removed impurity afterwash, section, grind then, cross 60 mesh sieves, standby; At first the Spica Prunellae after handling is extracted: with the water extraction of 8 times of amounts of medical material, extracting temperature is 95 ± 3 ℃, and being adjusted to pH with 10% acid for the first time is 2-5, decocts 2 hours; Extract for the second time 8 times that will water add to medical material weight, regulating pH with 10% alkali is 8-9, and extraction time is 1.5 hours, and medicinal liquid filters the back merging respectively, and filtrate is concentrated into relative density and is about 1.34-1.36g/cm
3, 70 ℃ thick paste, thick paste carries out vacuum drying, pulverizes; Or merging rear filtrate, to be concentrated into relative density be 1.10-1.20g/cm
3, 70 ℃ clear paste is pulverized after the spray drying and is promptly got the smart powder of Spica Prunellae, and yield is 7.6%-11.4%.
A kind of method for making with animal medicament of clearing away liver-fire, Disperse hepatic depression function, comprise the Spica Prunellae medical material is removed impurity afterwash, cutting, grind then, cross 60 mesh sieves, standby, it is characterized in that at first the Spica Prunellae after handling being extracted: with the water extraction of 8 times of amounts of medical material, extracting temperature is 95 ± 3 ℃, for the first time being adjusted to pH with 10% acid is 2-5, decocts 2 hours; Extract for the second time 8 times that will water add to medical material weight, pH is 8-9 with the adjusting of 10% alkali, and extraction time is 1.5 hours; Medicinal liquid filters the back respectively and merges, and filtrate is concentrated into relative density and is about 1.34-1.36g/cm
3, 70 ℃ thick paste, thick paste carries out vacuum drying, pulverizes; Or merging rear filtrate, to be concentrated into relative density be 1.10-1.20g/cm
3, 70 ℃ clear paste is pulverized after the spray drying and is promptly got the smart powder of Spica Prunellae, and yield is 7.6%-11.4%.
Have clearing away liver-fire, Disperse hepatic depression function animal medicament and a method for making thereof according to described, it is characterized in that described acid is with hydrochloric acid or lactic acid; Alkali is to regulate pH value with sodium hydroxide.
Finished product of the present invention can be made multiple dosage form as required, adds appropriate amount of auxiliary materials and can be used as injection, is used for intramuscular injection; Directly medicinal can mixed feeding or mix drink; Carry out breast or intestinal perfusion after also can be water-soluble with powder.
Be the therapeutic effect of checking medicine of the present invention, carry out following experiment Pullorum Disease:
Experimental animal
The AA broiler is provided by Tianjin side's big fowl industry company limited.Test chicken is without vaccine immunities such as Pullorum Disease, and male and female has concurrently, transports laboratory immediately back after going out shell, raises routinely on adjustable temperature control net cage, feeds complete feedstuff, free choice feeding and drinking-water, and carry out clinical observation.Artificial challenge's white diarrhea disease during raising to 7 age in days infects the back and observed 5 days.Test chicken body weight and grouping situation see Table 1.
Manual-induced white diarrhea disease
Strain: the Pullorum Disease Salmonella is provided by TanJin Agricultural College microorganism teaching and research room.Before the use, the virulent strain of preservation is the inoculation ordinary flat earlier.Cultivate after 24 hours, select colonies typical in meat soup, cultivate after 18 hours for 37 ℃ and take out.Calculating turbidity unit with the Maxwell turbidimetry, is 5 * 10
6Bacterium/ml.
The artificial challenge: per os gavaged Pullorum Disease Salmonella liquid 1ml when chickling was supported to 7 ages in days, contained 500,000,000 bacterium approximately.Cardinal symptom for depressed, the appetite of spirit descends, the feather pine disorderly, sagging, the lethargy of closing one's eyes of both wings, drop-head stays and stands, draws white or kermesinus loose stool.The visible lung of postmortem is kermesinus, and liver has a large amount of point-like or striated hemorrhage, and there is turbid liquid in the thoracic cavity, and pericardium has the cellulose calmness, and kidney is pale, urate deposition is arranged, and caseous substance is arranged in the caecum.Part night blindness enteral is mixed with blood, and is all separable to a large amount of Pullorum Disease Salmonellas by liver, spleen, lung.The proof experimental chicken is infected chicken Hakuri Salmonella.
Therapeutic evaluation
Mortality rate: the Pullorum Disease classical symptom occurs and death in that duration of test is all, necropsy has the characteristic pathological changes, and separation and Culture goes out Pullorum Disease Salmonella person from liver, spleen, lung, is judged to infect deadly, calculates mortality rate of each group.
Cure rate: allly recover normal person and be judged to healing, account for the ratio calculating cure rate of this group test chicken according to curing chicken at duration of test various transference cures after the drinking-water medication.
Weightening finish: the body weight of every chicken during according to on-test and end, the weightening finish of calculating every chicken.With the weightening finish of normal healthy controls (negative control) group is 100%, and each group weightening finish is compared with the weightening finish of normal healthy controls group, calculates the relative weight gain rate of each group.
Data analysis and processing: all results all carry out significance test with biometrics.
The grouping of table 1 experimental chicken
| Numbering | Group | Quantity (only) | Body weight (g) | Handle |
| 1 2 3 4 5 6 7 | Normal healthy controls infects the safe control group of dosage group low dose group medicine control group in the contrast high dose group | 50 50 50 50 50 50 50 | 146.36±12.54 148.35±12.78 145.27±11.75 143.42±10.76 149.46±12.86 147.13±10.34 146.91±11.43 | Do not infect, not administration is infected, not administration 0.2g/ only mixes drink, infect 0.1g/ and only mix drink, infect 0.05g/ and only mix drink, infect 2g/ and only mix drink, infect 2g/ and only mix drink, do not infect |
Each is organized the test chicken result of the test and sees Table 2
The various medicines of table 2 are to the curative effect of the white scour of chicken
| Numbering | Group | Death toll (only) | Mortality rate (%) | Cure rate (%) | Body weight (g) | The relative weight gain rate (%) |
| 1 2 3 4 5 6 | Normal healthy controls infects dosage group low dose group medicine matched group in the contrast high dose group | 0 28 3 4 10 17 | 0 56 6 6 20 34 | 84 82 70 54 | 365.9 232.8 356.2 353.0 345.1 346.8 | 100 62.3 94.5 93.2 81.6 75.4 |
Statistical results show, smart basic, normal, high dosage group of powder of Spica Prunellae and Spica Prunellae powder group mortality rate all extremely significantly are lower than infection matched group (P＜0.01), and cure rate is higher, illustrates that smart powder of Spica Prunellae and Spica Prunellae powder foot couple Pullorum Disease have curative effect preferably.The mortality rate and the cure rate of smart basic, normal, high dosage group of powder of Spica Prunellae and Spica Prunellae powder group comparison shows that best with the smart powder group of middle and high dosage Spica Prunellae, its mortality rate extremely significantly is lower than smart powder of low dosage Spica Prunellae and Spica Prunellae powder group (P＜0.01); The smart powder of proof Spica Prunellae has certain therapeutic effect to the treatment Pullorum Disease, and is best with the therapeutic effect of the smart powder of middle and high dosage Spica Prunellae especially.
Beneficial effect of the present invention: above-mentioned method for making has been broken the traditional human Chinese medicine secondary neutral water extraction or the method for decocting in water precipitate with ethanol, leaching process adopts partly bionical---sour earlier back alkaline extraction, the effective ingredient that has farthest kept Spica Prunellae, be particularly suitable for the poultry medication, in leaching process, do not use organic solvent, reduced the step that also will extract organic solvent, avoided the organic solvent residue problem with behind the organic solvent extraction.Protect the effective ingredient in the medicine to greatest extent, reduced production cost.
Utilize the traditional Chinese medicine of this flavor of Spica Prunellae, design the said extracted method according to the character of its extract, effective ingredient in the Spica Prunellae is farthest extracted, overcome because the special physiological structure of poultry, directly take the difficult shortcoming that absorbs of former powder, effective ingredient can be absorbed fully, reduced aquaculture cost.And preparation of the present invention is a pure Chinese medicinal preparation, without any toxic and side effects, and drug residue free.
The specific embodiment
Embodiment 1: get Spica Prunellae medical material 100kg, with the Spica Prunellae medical material wash on request, pick up, cut, dry, to pulverize the back standby.Extracting temperature is 95 ± 3 ℃, and amount of water is 8 times of medical material weight for the first time, the acid for adjusting pH to 3 with 10%, and extraction time is 2 hours; For the second time amount of water still be 8 times of medical material weight, and with 10% alkali adjusting pH to 8.5, extraction time is 1.5 hours.Being concentrated into proportion is 1.20g/cm
3(70 ℃) get thick paste, pulverize after the spray drying, promptly get the smart powder 8.6kg (yield is 8.6%) of Spica Prunellae.Oral drugs absorb good, and instant effect is without any side effects, is used for the treatment of mammitis of cow, the 0.3g/kg body weight, and once a day, 3-5 days is a course of treatment, decides according to state of an illness weight, evident in efficacy, and higher cure rate is arranged.
Embodiment 2: get Spica Prunellae medical material 100kg, method for making is the same.Can make the smart powder 10.8kg (extraction ratio is 10.8%) of Spica Prunellae.Get the smart powder of the Spica Prunellae that makes and directly carry out mixed feeding in right amount, be used for the treatment of piglet pujos blancos, 3g/ days/head, 3-5 days was a course of treatment, and cure rate can reach 91%.
Embodiment 3: get Spica Prunellae medical material 100kg, method for making is the same.Can make the smart powder 9.2kg (extraction ratio is 9.2%) of Spica Prunellae.Be used for the treatment of Pullorum Disease, 0.15g//day, 3-5 days is a course of treatment, and cure rate can reach 94%.
Claims (3)
1, a kind of animal medicament with clearing away liver-fire, Disperse hepatic depression function is characterized in that being is the medicament that raw material is made by Spica Prunellae
Dose processing method: Spica Prunellae is removed impurity afterwash, cutting, grind then, cross 60 mesh sieves, standby; At first the Spica Prunellae after handling is extracted: with the water extraction of 8 times of amounts of medical material, extracting temperature is 95 ± 3 ℃, and being adjusted to pH with 10% acid for the first time is 2-5, decocts 1 hour; Extract for the second time 8 times that will water add to medical material weight, regulating pH with 10% alkali is 8-9, and extraction time is 0.5 hour, and medicinal liquid filters the back merging respectively, and filtrate is concentrated into relative density and is about 1.34-1.36g/cm
3, 70 ℃ thick paste, thick paste carries out vacuum drying, pulverizes; Or filtrate to be concentrated into relative density be 1.10-1.20g/cm
3, 70 ℃ clear paste is pulverized after the spray drying and is promptly got the smart powder of Spica Prunellae, and yield is 7.6%-11.4%.
2, a kind of method for making with animal medicament of clearing away liver-fire, Disperse hepatic depression function, comprise the Spica Prunellae medical material is removed impurity afterwash, cutting, grind then, cross 60 mesh sieves, standby, it is characterized in that at first the Spica Prunellae after handling being extracted: with the water extraction of 8 times of amounts of medical material, extracting temperature is 95 ± 3 ℃, for the first time being adjusted to pH with 10% acid is 2-5, decocts 1 hour; Extract for the second time 8 times that will water add to medical material weight, pH is 8-9 with the adjusting of 10% alkali, and extraction time is 0.5 hour; Medicinal liquid filters the back respectively and merges, and promptly gets the Spica Prunellae extracting solution, and the Spica Prunellae extracting solution is concentrated into relative density and is about 1.34-1.36g/cm
3, 70 ℃ thick paste, thick paste carries out vacuum drying, pulverizes; Or filtrate to be concentrated into relative density be 1.10-1.20g/cm
3, 70 ℃ clear paste is pulverized after the spray drying and is promptly got the smart powder of Spica Prunellae, and yield is 7.6%-11.4%.
3, according to claim 1 and 2 described animal medicament and method for makings thereof, it is characterized in that described acid is hydrochloric acid or lactic acid with clearing away liver-fire, Disperse hepatic depression function; Alkali is to regulate pH value with sodium hydroxide.
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| CN 200510015180 CN1939401A (en) | 2005-09-26 | 2005-09-26 | Animal medicament with liverfire-clearing and digesting functions and its making method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102144718B (en) * | 2010-02-08 | 2014-12-03 | 上海百树生物科技有限公司 | Selfheal extract feed additive and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102144718B (en) * | 2010-02-08 | 2014-12-03 | 上海百树生物科技有限公司 | Selfheal extract feed additive and preparation method thereof |
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