CN1939359A - Animal pharmacon with worm-expelling, phlegm-dispelling and stagnancy-resolving functions and its preparation - Google Patents
Animal pharmacon with worm-expelling, phlegm-dispelling and stagnancy-resolving functions and its preparation Download PDFInfo
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- CN1939359A CN1939359A CN 200510015175 CN200510015175A CN1939359A CN 1939359 A CN1939359 A CN 1939359A CN 200510015175 CN200510015175 CN 200510015175 CN 200510015175 A CN200510015175 A CN 200510015175A CN 1939359 A CN1939359 A CN 1939359A
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Abstract
A veterinary medicine with the functions of killing parasite, eliminating sputum and promoting digestion for treating the epidemic diseases of domestic animals and fowls is prepared from antifebrile dichroa root through pre-treating, decocting in water for 2 hr while using acid to regulate pH=2-5, filtering, decocting again for 1.5 hr while using alkali to regulate pH=8-9, filtering, collecting the decoction, drying and pulverizing.
Description
Technical field
The present invention relates to derive from the technical field of medicinal preparation (international Patent classificating number 35/79) of the product that contains not clear structure of plant, relating to the Chinese crude drug Radix Dichroae is the animal medicament and the method for making thereof of a kind of parasite killing of feedstock production, expectorant removing food stagnancy function.
Background technology
Chinese medicine and pharmacy is one of important component part in the cultural treasure-house of China's medicine, and Chinese herbal medicine then is the culture rarity of China.Aspect animal medicine, traditional Chinese veterinary medicine is also playing crucial effect aspect the Clinics and Practices of livestock and poultry.
(different name is grass mutually, comes from " herbal classic " for Radix Dichroae; Hengshan Mountain, seven leaves come from " WU Pu Bencao ") be one of anthelmintic medical material commonly used in the Chinese medicine for animals, its pharmacological action of modern study: contained alkaloid has very strong inhibitory action to plasmodium; Radix Dichroae first, second, third all has hypotensive effect.2000 editions veterinary drug allusion quotations are recorded its medical material and are used for the treatment of diseases such as coccidiosis of livestock and poultry, the impaction of rumen.
In clinical use; because modern large-scale cultivation degree improves constantly; directly the Chinese medicine crude drug is carried out the mixed feeding administration and usually cause problems such as administration inconvenience, abnormal smells from the patient is dense, absorbance is low; make the Radix Dichroae drug effect not bring into play fully; and the extracting method of Radix Dichroae adopts common decocting method to extract usually, has lost the mass efficient composition.Do not retrieve at present the application of the smart powder of Radix Dichroae on livestock and poultry pestilence as yet, on human, be commonly used to treat malaria.The extractive technique of Radix Dichroae is the extractive technique of human medicine often, and technical sophistication, cost height are used for poultry medication and uneconomical; And the said extracted process usually can be removed the nutritional labelings such as protein in the Chinese medicine, and this has improved aquaculture cost virtually again for livestock and poultry cultivation.
Summary of the invention
The objective of the invention is for a kind of smart powder preparation of Radix Dichroae with functions such as parasite killing, expectorant removing food stagnancy is provided.Be used to cure mainly diseases such as coccidiosis of livestock and poultry, the impaction of rumen, but mixed feeding also can be mixed the drink administration, simultaneously again can be as the raw material of further preparation.The infectious disease of treatment poultry generally adopts antibiotherapy at present, heavy dose of antibiotic that feeds also makes the intravital normal flora of machine suffer to destroy and imbalance in the treatment disease, causes producing in the body residual in animal foodstuff of Resistant strain and medicine.Radix Dichroae nature and flavor hardship, suffering, cold can be gone into lung, liver, heart channel, can play the effect of parasite killing, expectorant removing food stagnancy.And the present invention---the smart powder of Radix Dichroae can be eliminated symptom quickly for the parasitic disease of poultry, promotes body recovery.The smart powder side effect of Radix Dichroae is little, the no obvious toxic and side effects in oral back, and do not produce drug resistance after using, body is interior without any drug residue.
It is comparatively simple that another object of the present invention just provides a kind of extracting method, is used for the lower-cost a kind of method for making with animal medicament of parasite killing, expectorant removing food stagnancy function of the treatment of livestock and poultry pestilence.
For reach the foregoing invention purpose the invention provides a kind of have parasite killing, expectorant removing food stagnancy siddhi can animal medicament, it is characterized in that this medicament is is the medicament that raw material is made by Radix Dichroae.
Dose processing method: Radix Dichroae is removed impurity afterwash, cutting, grind then, cross 60 mesh sieves, standby; At first the Radix Dichroae after handling is extracted: with the water extraction of 8 times of amounts of medical material, extracting temperature is 95 ± 3 ℃, and being adjusted to pH with 10% acid for the first time is 2-5, decocts 2 hours; Extract for the second time 8 times that will water add to medical material weight, regulating pH with 10% alkali is 8-9, and extraction time is 1.5 hours, and medicinal liquid filters the back merging respectively, and filtrate is concentrated into relative density and is about 1.34-1.36g/cm
3, 70 ℃ thick paste, thick paste carries out vacuum drying, pulverizes; Or merging rear filtrate, to be concentrated into relative density be 1.10-1.20g/cm
3, 70 ℃ clear paste, spray drying is pulverized; Yield is 9.6%-14.4%.
A kind of method for making with animal medicament of parasite killing, expectorant removing food stagnancy function, comprise the Radix Dichroae medical material is removed impurity afterwash, cutting, grind then, cross 60 mesh sieves, standby, it is characterized in that at first the Radix Dichroae after handling being extracted: with the water extraction of 8 times of amounts of medical material, extracting temperature is 95 ± 3 ℃, for the first time being adjusted to pH with 10% acid is 2-5, decocts 2 hours; Extract for the second time 8 times that will water add to medical material weight, pH is 8-9 with the adjusting of 10% alkali, and extraction time is 1.5 hours; Medicinal liquid filters the back respectively and merges, and promptly gets the Radix Dichroae extracting solution, and the Radix Dichroae extracting solution is concentrated into relative density and is about 1.34-1.36g/cm
3, 70 ℃ thick paste, thick paste carries out vacuum drying, pulverizes; Or merging rear filtrate, to be concentrated into relative density be 1.10-1.20g/cm
3, 70 ℃ clear paste, spray drying is pulverized and is promptly got the smart powder (yield is 9.6%-14.4%) of Radix Dichroae.
Have parasite killing, expectorant removing food stagnancy function animal medicament and a method for making thereof according to described, it is characterized in that described acid is hydrochloric acid or lactic acid; Alkali is to regulate pH value with sodium hydroxide.
Finished product of the present invention can be made multiple dosage form as required, adds appropriate amount of auxiliary materials and can be used as injection, is used for intramuscular injection; Directly medicinal can mixed feeding or mix drink; Carry out intestinal perfusion after also can be water-soluble with powder.
It is respond well to confirm that by experiment this medicine is used for the treatment of chicken coccidiosis, and experimental result is as follows:
The experiment medicine: the smart powder of Radix Dichroae, control drug is that the Radix Dichroae decoction pieces is made Antifeverile Dichroa Root after crushed.
Laboratory animal
350 AA broiler, available from the big fowl industry in Tianjin side Development Co., Ltd, be divided into seven groups at random, be respectively the smart powder high dose group of Radix Dichroae, dosage group in the smart powder of Radix Dichroae, the smart powder low dose group of Radix Dichroae, the Antifeverile Dichroa Root matched group, negative control group (group is not treated in morbidity), positive controls (do not fall ill and do not treat group), safe matched group (according to 10 times of administration groups of recommended dose), 50 every group.Go out to be transported in this laboratory pouity dwelling place behind the shell and raise in cages, Routine Management is fed to complete feed to 21 age in days, is for experiment after excrement is examined the non-ball worm egg capsule.
The artificial challenge
Except that positive controls and safe matched group, every plumage chicken gavages 100,000 spore Eimeria tenella egg capsules (the Eimeria tenella egg capsule is provided by TanJin Agricultural College).
Medication
It is soluble in water that every group of medicine pressed doses, allows chicken freely drink water.Administration when infecting, logotype 6 days.
The result judges
Observe chicken manure after the medication and just reach clinical symptoms.Weighing to cut open and kill in the infection back on the 6th day, observes intestinal (small intestinal, caecum) pathological changes, carries out caecum egg capsule counting with Maxwell egg count method.
Average weight before average weight-on-test during average weight gain average weight gain=off-test.
The relative weight gain rate the relative weight gain rate=(each medication group or negative control group average weight gain/positive controls average weight gain) * 100%
Survival rate survival rate=(the chicken number during survival chicken number/on-test) * 100%
Lesion score is kept the score according to the order of severity of cuing open inspection rear intestinal pathological changes.No pathological changes is kept the score and is "-"; Slight lesion score is "+"; The caecum wall thickening has to be " ++ " to medium hemorrhage keeping the score for a short time; In have a lot of clots to keep the score to be " +++"; Keep the score because of coccidiosis death and to be " ++ ++ ".
The pathological changes value is kept the score according to the order of severity of cuing open inspection rear intestinal pathological changes.With reference to the standard of Merck Sharp, i.e. the average of the lesion score of every group of experimental chicken * 10
Hemafecia is kept the score with reference to Morehouse and Baron standard, and promptly 5d begins to observe the blood stool situation behind the artificial challenge, and continuously 2d keeps the score, and do complete group average.
The egg capsule value is according to the O.P.G value, and tabling look-up draws.
The anticoccidial index is according to the computing formula of Merck (Merck) company, and ACI=(the relative weight gain rate+survival rate)-(pathological changes value+egg capsule value) obtained.
Test grouping and processing (seeing Table 1):
The grouping of table 1 experimental chicken and processing
Experimental result is as follows:
The smart powder of table 2 Radix Dichroae is to the therapeutic effect of chicken coccidiosis
| The test grouping | Test chicken number (only) | With concentration (g/L water) | Survival rate (%) | Average weight gain g/ only | The relative weight gain rate % | Hemafecia keep the score (0-4) | Pathological changes value (0-40) | Egg capsule value (0-40) | Anticoccidial index (ACI) |
| Dosage group high dose group does not infect not administration group and infects the safe control group of not administration group medicine control group in the low dose group | 50 50 50 50 50 50 50 | 0.25 0.5 1.0 - - 1.2 5.0 | 100 100 100 100 72 88 100 | 164.4 174.7 176.0 183.7 107.2 137.3 | 89.5 951 95.8 100 68.2 82.3 | 0.2 0 0 0 4.0 0.9 | 20 0 0 0 40 9 | 8 0 0 0 32 8 | 151.5 195.1 195.8 68.2 153.3 |
Result by above test shows, the anticoccidial index of the smart powder various dose group of Radix Dichroae (basic, normal, high) is respectively 151.5,195.1 and 195.8, wherein middle and high dosage group belongs to the anticoccidial high efficiency levels, and low dose group also is in the effective range of the smart powder of Radix Dichroae; Antifeverile Dichroa Root matched group anticoccidial index is 153.3, and the anticoccidial level is lower than the smart powder of Radix Dichroae.On rate of body weight gain, the middle and high dosage group of the smart powder of Radix Dichroae is the highest, can more effectively improve chicken group's rate of body weight gain than Antifeverile Dichroa Root matched group.The caecum lesion value of the middle and high dosage group of the smart powder of Radix Dichroae and egg capsule value be low than material medicine matched group obviously.By the safety experiment (10 times of amount recommendations are oral, logotype five days) to healthy chicken, the clinical manifestation of no abnormality seen between the operating period illustrates that said preparation does not have obvious influence to healthy chicken, and is safe in utilization simultaneously.
The invention has the beneficial effects as follows: above-mentioned method for making has been broken the traditional human Chinese medicine secondary neutral water extraction or the method for decocting in water precipitate with ethanol, leaching process adopts partly bionical---sour earlier back alkaline extraction, the effective ingredient that has farthest kept Radix Dichroae, be particularly suitable for the poultry medication, in leaching process, do not use organic solvent, reduced the step that also will extract organic solvent, avoided the organic solvent residue problem with behind the organic solvent extraction.Protect the effective ingredient in the medicine to greatest extent, reduced production cost.
By zoopery, confirmed that the respiratory tract disease of the smart treated powder domestic animal of Radix Dichroae, poultry has excellent curative, played the effect of parasite killing, expectorant removing food stagnancy.Confirmed the purposes of the smart powder of Radix Dichroae on the treatment livestock and poultry pestilence.Since process using water extraction of the present invention, the method for sour earlier back alkali, water temperature raising degree is higher, has kept the effective ingredient in the medicine, and the active component in the smart powder has overcome the difficult difficulty that absorbs of Radix Dichroae crude drug.After water is carried, do not adopt alcohol deposition method, kept the nutritions such as protein in the medicine, after poultry are taken in, help the growth of poultry, thereby improved the economic benefit of culturing, reduced the medicine production cost.Generally speaking reduced aquaculture cost, solved because of Resistant strain exists and used the inoperative difficulty of antibiotic therapy.Be used for the treatment of domestic animal, poultry because of the infectiousness eqpidemic disease has excellent curative, played the effect of parasite killing, expectorant removing food stagnancy.
The specific embodiment:
Embodiment 1: get Radix Dichroae medical material 100kg, with the Radix Dichroae raw material wash on request, pick up, cut, dry, pulverized behind 60 mesh sieves standby.Extracting temperature is 95 ± 3 ℃, and amount of water is 8 times of medical material weight for the first time, the acid for adjusting pH to 3 with 10%, and extraction time is 2 hours; For the second time amount of water still be 8 times of medical material weight, and with 10% alkali adjusting pH to 8.5, extraction time is 1 hour.80 ℃ of thickening temperatures, vacuum-0.09Mpa, being concentrated into proportion is 1.20g/cm
3(80 ℃).Spray drying or vacuum decompression crushed after being dried promptly get the smart powder 12kg (yield is 12%) of Radix Dichroae.
Certain chicken house chicken group infects chronic respiratory tract disease, and symptoms such as shedding tears appears in most of chicken group, sneeze, cough are not seen obvious improvement with effect after the Drug therapy of treatment Mycoplasma.Adopt medicine of the present invention, 0.3g/ only/day, freely drink water, carry out five days by a definite date treatment after, most of sick fowl disease close friend commentaries on classics, symptom disappears substantially, cure rate has reached 92%.
Embodiment 2: get Radix Dichroae medical material 100kg, method for making is with embodiment 1.Can get the smart powder 14kg (yield is 14%) of Radix Dichroae after the extraction.Certain pig farm is because of immuning failure, almost full group infected pigs asthma, and state of an illness weight differs, and after taking measures to carry out urgent immunity, adds medicine of the present invention, 1g/kg feedstuff, logotype 5 days in feedstuff.Most of sick swine diseases feelings begin to take a turn for the better gradually after 5 days, normal feed of beginning and drinking-water.After continuing to strengthen treatment, be almost recovered.
Claims (3)
1, a kind of animal medicament with parasite killing, expectorant removing food stagnancy function is characterized in that being is the medicament that raw material is made by Radix Dichroae
Dose processing method: Radix Dichroae is removed impurity afterwash, cutting, grind then, cross 60 mesh sieves, standby; At first the Radix Dichroae after handling is extracted: with the water extraction of 8 times of amounts of medical material, extracting temperature is 95 ± 3 ℃, and being adjusted to pH with 10% acid for the first time is 2-5, decocts 2 hours; Extract for the second time 8 times that will water add to medical material weight, regulating pH with 10% alkali is 8-9, and extraction time is 1.5 hours, and medicinal liquid filters the back merging respectively, and filtrate is concentrated into relative density and is about 1.34-1.36g/cm
3, 70 ℃ thick paste, thick paste carries out vacuum drying, pulverizes; Or merging rear filtrate, to be concentrated into relative density be 1.10-1.20g/cm
3, 70 ℃ clear paste, spray drying is pulverized and is promptly got the smart powder of Radix Dichroae, and yield is 9.6%-14.4%.
2, a kind of method for making with animal medicament of parasite killing, expectorant removing food stagnancy function, comprise the Radix Dichroae medical material is removed impurity afterwash, cutting, grind then, cross 60 mesh sieves, standby, it is characterized in that at first the Radix Dichroae after handling being extracted: with the water extraction of 8 times of amounts of medical material, extracting temperature is 95 ± 3 ℃, for the first time being adjusted to pH with 10% acid is 2-5, decocts 2 hours; Extract for the second time 8 times that will water add to medical material weight, pH is 8-9 with the adjusting of 10% alkali, and extraction time is 1.5 hours; Medicinal liquid filters the back respectively and merges, and promptly gets the Radix Dichroae extracting solution, and the Radix Dichroae extracting solution is concentrated into relative density and is about 1.34-1.36g/cm
3, 70 ℃ thick paste, thick paste carries out vacuum drying, pulverizes; Or merging rear filtrate, to be concentrated into relative density be 1.10-1.20g/cm
3, 70 ℃ clear paste, spray drying is pulverized and is promptly got the smart powder of Radix Dichroae, and yield is 9.6%-14.4%.
3, describedly have parasite killing, expectorant removing food stagnancy function animal medicament and a method for making thereof according to claim 1 and 2, it is characterized in that described acid is hydrochloric acid or lactic acid; Alkali is to regulate pH value with sodium hydroxide.
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| CN 200510015175 CN1939359A (en) | 2005-09-26 | 2005-09-26 | Animal pharmacon with worm-expelling, phlegm-dispelling and stagnancy-resolving functions and its preparation |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112656825A (en) * | 2021-01-12 | 2021-04-16 | 中国农业科学院兰州畜牧与兽药研究所 | Preparation method and application of traditional Chinese medicine pesticide |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112656825A (en) * | 2021-01-12 | 2021-04-16 | 中国农业科学院兰州畜牧与兽药研究所 | Preparation method and application of traditional Chinese medicine pesticide |
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