CN1935181B - Animal medicament with the functioin of curing infectious bronchitis of chicken, and its preparing method - Google Patents
Animal medicament with the functioin of curing infectious bronchitis of chicken, and its preparing method Download PDFInfo
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- CN1935181B CN1935181B CN 200510015121 CN200510015121A CN1935181B CN 1935181 B CN1935181 B CN 1935181B CN 200510015121 CN200510015121 CN 200510015121 CN 200510015121 A CN200510015121 A CN 200510015121A CN 1935181 B CN1935181 B CN 1935181B
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Abstract
The present invention relates to an animal medicine astragalus powder with the functions of invigorating qi and strengthening the body surface resistance, promoting pus discharge and expelling toxin for curing animal diseases. It is made up by using Chinese medicinal material astragalus root as raw material through a certain preparation process. Said invention also provides the concrete steps of said preparation process.
Description
Technical field
The present invention relates to derive from the technical field of medicinal preparation (international Patent classificating number 35/79) of the product that contains not clear structure of plant, relating to the Chinese crude drug Radix Astragali is the animal medicament and the method for making thereof of a kind of invigorating QI to consolidate the body surface resistance of feedstock production, expelling pus and toxin by strengthening QI function.
Background technology
Chinese medicine and pharmacy is one of important component part in the cultural treasure-house of China's medicine, and Chinese herbal medicine then is the culture rarity of China.Aspect animal medicine, traditional Chinese veterinary medicine is also playing crucial effect aspect the Clinics and Practices of livestock and poultry.
(the continuous Radix Astragali of different name comes from " Bencao Tujing " to the Radix Astragali; Wear crushed grain, come from Shennong's Herbal; The Rhizoma Paridis tetraphyllae comes from " property of medicine opinion "; The arrow stilbene comes from " medical science is integrated "; The only son and heir comes from " Gansu Chinese medicine handbook; Radix Astragali comes from Shennong's Herbal) be one of heat-clearing and toxic substances removing the most frequently used in the Chinese medicine for animals, enhancing human body immunity power medical material.The Radix Astragali is sweet in flavor and warm in property, returns lung, spleen channel, and 2000 editions veterinary drug allusion quotations are recorded its pharmaceutical decocting piece and are used for poultry invigorating QI to consolidate the body surface resistance, expelling pus and toxin by strengthening QI, expelling pus and promoting granulation, effects such as inducing diuresis to remove edema cure mainly asthenia of pulmonosplenic qi, and the body sweating due to debility goes out, sinking of QI of middle-JIAO, deficiency of vital energy edema, carbuncle sore is difficult bursts, and losing for a long time bursts does not hold back diseases such as blood deficiency.
In clinical use; because modern large-scale cultivation; directly the Chinese medicine crude drug is carried out the mixed feeding administration and usually cause problems such as administration inconvenience, abnormal smells from the patient is dense, absorbance is low; make Radix Astragali drug effect not bring into play fully; take common decocting in water precipitate with ethanol to extract and write " Radix Astragali extract " that record in " Chinese herbal medicine extract " as the Hou Tuanzhang that Chinese Medicine science and technology publishing house publishes; not only waste a large amount of ethanol, also lost the mass efficient composition simultaneously.At present do not retrieve the application of Radix Astragali essenc powder on livestock and poultry pestilence as yet, the extractive technique of the Radix Astragali usually is the extractive technique of human medicine, and technical sophistication, cost height are used for poultry medication and uneconomical; And the said extracted process usually can be removed the nutritional labelings such as protein in the Chinese medicine, and this has improved aquaculture cost virtually again for livestock and poultry cultivation.
Summary of the invention
The purpose of this invention is to provide a kind of Radix Astragali essenc powder preparation with functions such as invigorating QI to consolidate the body surface resistance, expelling pus and toxin by strengthening QI.Be used to cure mainly the animal anemopyretic cold, laryngopharynx swelling and pain, aphtha of the mouth and tongue, diseases such as skin ulcer general edema with yellowish skin poison, but mixed feeding also can be mixed the drink administration, and simultaneously again can be as the raw material of further preparation.Chemical medicinal treatment is generally adopted in bacillary, the viral infection of treatment domestic animal at present, heavy dose of chemical drugs that feeds also makes the intravital normal flora of machine suffer to destroy and imbalance in the treatment disease, causes producing in the body residual in animal foodstuff of Resistant strain and medicine.Radix Astragali nature and flavor hardship, cold can be gone into the heart, lung meridian, and gram positive bacteria and negative bacterium are had certain inhibitory action.And the present invention---the upper respiratory tract infection that the Radix Astragali essenc powder causes for virus can comparatively fast be eliminated symptom, promotes body recovery.The side effect of Radix Astragali essenc powder is little, the no obvious toxic and side effects in oral back, and do not produce drug resistance after using, body is interior without any drug residue.
Another object of the present invention provides a kind of method for making with animal medicament of invigorating QI to consolidate the body surface resistance, expelling pus and toxin by strengthening QI function.
In order to reach purpose of the present invention, the technical scheme of employing is: the invention provides a kind of have invigorating QI to consolidate the body surface resistance, expelling pus and toxin by strengthening QI function animal medicament, it is characterized in that this medicament is is the medicament that raw material is made by the Radix Astragali.
Dose processing method: the Radix Astragali is removed impurity afterwash, cutting, grind then, cross 60 mesh sieves, standby; At first the Radix Astragali after handling is extracted: with the water extraction of 8 times of amounts of medical material, extracting temperature is 95 ± 3 ℃, and being adjusted to pH with 10% acid for the first time is 2-5, decocts 2 hours; Extract for the second time 8 times that will water add to medical material weight, regulating pH with 10% alkali is 8-9, and extraction time is 1.5 hours, and medicinal liquid filters the back merging respectively, and filtrate is concentrated into relative density and is about 1.34-1.36g/cm
3, 70 ℃ thick paste, thick paste carries out vacuum drying, pulverizes; Or merging rear filtrate, to be concentrated into relative density be 1.10-1.20g/cm
3, 70 ℃ clear paste, spray drying promptly gets the Radix Astragali essenc powder, and yield is 15.8%-23.8%.
A kind of method for making with animal medicament of invigorating QI to consolidate the body surface resistance, expelling pus and toxin by strengthening QI function, comprise Milkvetch Root is removed impurity afterwash, cutting, grind then, cross 60 mesh sieves, standby, it is characterized in that at first the Radix Astragali after handling being extracted: with the water extraction of 8 times of amounts of medical material, extracting temperature is 95 ± 3 ℃, for the first time being adjusted to pH with 10% acid is 2-5, decocts 2 hours; Extract for the second time 8 times that will water add to medical material weight, pH is 8-9 with the adjusting of 10% alkali, and extraction time is 1.5 hours; Medicinal liquid filters the back respectively and merges, and promptly gets Radix Astragali extractive solution, and Radix Astragali extractive solution is concentrated into relative density and is about 1.34-1.36g/cm
3, 70 ℃ thick paste, thick paste carries out vacuum drying, pulverizes; Or Radix Astragali extractive solution to be concentrated into relative density be 1.10-1.20g/cm
3, 70 ℃ clear paste, spray drying promptly gets Radix Astragali essenc powder (yield is 15.8%-23.8%).
Have invigorating QI to consolidate the body surface resistance, expelling pus and toxin by strengthening QI function animal medicament and a method for making thereof according to described, it is characterized in that described acid is hydrochloric acid or lactic acid; Alkali is to regulate pH value with sodium hydroxide.
Finished product of the present invention can be made multiple dosage form as required, adds appropriate amount of auxiliary materials and can be used as injection, is used for intramuscular injection; Directly medicinal can mixed feeding or mix drink; Carry out breast or intestinal perfusion after also can be water-soluble with powder.
It is respond well to confirm that by experiment this medicine is used for the treatment of infectious bronchitis of chicken, and test grouping and result of the test see Table 1, table 2:
The grouping of table 1 test chicken and processing
Annotate: the test drug that the Milkvetch Root matched group is used is that Radix Astragali decoction pieces was through pulverizing the powder of 60 mesh sieves
Table 2 Radix Astragali essenc powder is to the clinical trial result of infectious avian bronchitis
Statistical results show, basic, normal, high dosage group of Radix Astragali essenc powder and Milkvetch Root group mortality rate all extremely significantly are lower than infection matched group (P＜0.01).The cure rate utmost point is significantly higher than and infects matched group (P＜0.01), illustrates that Radix Astragali essenc powder and Milkvetch Root have curative effect preferably to infectious bronchitis of chicken.The mortality rate and the cure rate of basic, normal, high dosage group of Radix Astragali essenc powder and Milkvetch Root group comparison shows that best with middle and high dosage Radix Astragali essenc powder group, its mortality rate extremely significantly is lower than low dosage Radix Astragali essenc powder group and Milkvetch Root group (P＜0.01); Proof Radix Astragali essenc powder has certain therapeutic effect to the treatment infectious bronchitis, and is best with the therapeutic effect of middle and high dosage Radix Astragali essenc powder especially.
Above-mentioned method for making has been broken the traditional human Chinese medicine secondary neutral water extraction or the method for decocting in water precipitate with ethanol, leaching process adopts partly bionical---sour earlier back alkaline extraction, the effective ingredient that has farthest kept the Radix Astragali, be particularly suitable for the poultry medication, in leaching process, do not use organic solvent, reduced the step that also will extract organic solvent, avoided the organic solvent residue problem with behind the organic solvent extraction.Protect the effective ingredient in the medicine to greatest extent, reduced production cost.
The invention has the beneficial effects as follows: by zoopery, confirmed Radix Astragali essenc treated powder domestic animal, poultry, played the effect of invigorating QI to consolidate the body surface resistance, expelling pus and toxin by strengthening QI because of the respiratory tract disease that infectious bronchitis causes has excellent curative.Confirmed the purposes of Radix Astragali essenc powder on the treatment livestock and poultry pestilence.Since process using water extraction of the present invention, the method for sour earlier back alkali, water temperature raising degree is higher, has kept the effective ingredient in the medicine, and the active component in the smart powder has overcome the difficult difficulty that absorbs of Radix Astragali crude drug.After water is carried, do not adopt alcohol deposition method, kept the nutritions such as protein in the medicine, after poultry are taken in, help the growth of poultry, thereby improved the economic benefit of culturing, reduced the medicine production cost.Be used for the treatment of domestic animal, poultry because of the infectiousness eqpidemic disease has excellent curative, played the effect of invigorating QI to consolidate the body surface resistance, expelling pus and toxin by strengthening QI.
The specific embodiment:
Embodiment 1: get Milkvetch Root 100kg, with Radix Astragali raw material wash on request, pick up, cut, dry, pulverized behind 60 mesh sieves standby.Extracting temperature is 95 ± 3 ℃, and amount of water is 8 times of medical material weight for the first time, the acid for adjusting pH to 3 with 10%, and extraction time is 2 hours; For the second time amount of water still be 8 times of medical material weight, and with 10% alkali adjusting pH to 8.5, extraction time is 1 hour.80 ℃ of thickening temperatures, vacuum-0.09Mpa, being concentrated into proportion is 1.20g/cm
3(70 ℃).Spray drying or vacuum decompression crushed after being dried promptly get Radix Astragali essenc powder 19.8kg (yield is 19.8%).
Certain chicken house chicken group infects chronic respiratory tract disease, and symptoms such as shedding tears appears in most of chicken group, sneeze, cough are not seen obvious improvement with effect after the Drug therapy of treatment Mycoplasma.Adopt medicine of the present invention, 0.05g/ plumage/sky is freely drunk water, carry out five days by a definite date treatment after, most of sick fowl disease close friend changes, symptom disappears substantially, cure rate has reached 92%.
Embodiment 2: get Milkvetch Root 100kg, method for making is with embodiment 1.Can get Radix Astragali essenc powder 20.3kg (yield is 20.3%) after the extraction.Certain pig farm is because of immuning failure, and almost full group is broken out porcine parvovirus, and state of an illness weight differs, and after taking measures to carry out urgent immunity, adds medicine of the present invention, 1g/kg feedstuff, logotype 5 days in feedstuff.Most of sick swine diseases feelings begin to take a turn for the better gradually after 5 days, normal feed of beginning and drinking-water.After continuing to strengthen treatment, be almost recovered.
Claims (4)
1. animal medicament with treatment infectious bronchitis of chicken function is characterized in that being is the medicament that raw material is made by the Radix Astragali
Dose processing method: the Radix Astragali is removed impurity afterwash, cutting, grind then, cross 60 mesh sieves, standby; At first the Radix Astragali after handling is extracted: with the water extraction of 8 times of amounts of medical material, extracting temperature is 95 ± 3 ℃, and being adjusted to pH with 10% acid for the first time is 2-5, decocts 2 hours; Extract for the second time 8 times that will water add to medical material weight, regulating pH with 10% alkali is 8-9, and extraction time is 1.5 hours, and medicinal liquid filters the back merging respectively, and filtrate is concentrated into relative density and is about 1.34-1.36g/cm
3, 70 ℃ thick paste, thick paste carries out vacuum drying, pulverizes; Or filtrate to be concentrated into relative density be 1.10-1.20g/cm
3, 70 ℃ clear paste, spray drying promptly gets the Radix Astragali essenc powder, and yield is 15.8%-23.8%.
2. a kind of animal medicament with treatment infectious bronchitis of chicken function according to claim 1 is characterized in that described acid is hydrochloric acid or lactic acid; Alkali is sodium hydroxide.
3. method for making with animal medicament of treatment infectious bronchitis of chicken function is characterized in that realizing by following technical step:
1) Milkvetch Root is removed impurity afterwash, cutting, ground then, cross 60 mesh sieves, standby;
2) Radix Astragali after handling is carried out extracting for the first time: with the water extraction of 8 times of amounts of medical material, extracting temperature is 95 ± 3 ℃, and being adjusted to pH with 10% acid for the first time is 2-5, decocts 2 hours;
3) extract for the second time 8 times that will water add to medical material weight, pH is 8-9 with the adjusting of 10% alkali, and extraction time is 1.5 hours;
4) medicinal liquid filters the back merging respectively, promptly gets Radix Astragali extractive solution;
5) Radix Astragali extractive solution is concentrated into relative density and is about 1.34-1.36g/cm
3, 70 ℃ thick paste, thick paste carries out vacuum drying, pulverizes, and gets the Radix Astragali essenc powder; Or Radix Astragali extractive solution is concentrated into relative density is 1.10-1.20g/cm
3, 70 ℃ clear paste, spray drying promptly gets the Radix Astragali essenc powder, and yield is 15.8%-23.8%.
4. a kind of method for making with animal medicament of treatment infectious bronchitis of chicken function according to claim 3 is characterized in that described acid is hydrochloric acid or lactic acid; Alkali is sodium hydroxide.
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| CN 200510015121 CN1935181B (en) | 2005-09-20 | 2005-09-20 | Animal medicament with the functioin of curing infectious bronchitis of chicken, and its preparing method |
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| CN1935181B true CN1935181B (en) | 2011-01-19 |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1533707A (en) * | 2003-03-28 | 2004-10-06 | 重庆石柱土家族自治县合力饲料厂 | Disease resistant quick fertilizing magic series, quick fertilizing extract series Chinese herbal medicine concentrated feed |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1533707A (en) * | 2003-03-28 | 2004-10-06 | 重庆石柱土家族自治县合力饲料厂 | Disease resistant quick fertilizing magic series, quick fertilizing extract series Chinese herbal medicine concentrated feed |
Non-Patent Citations (6)
| Title |
|---|
| 姜力等.黄芪多糖注射液对鸡传染性喉气管炎的防治试验.黑龙江畜牧兽医 1.1997,(1),24. |
| 姜力等.黄芪多糖注射液对鸡传染性喉气管炎的防治试验.黑龙江畜牧兽医 1.1997,(1),24. * |
| 孙瑞敏等.黄芪多糖的提取.南开大学学报38 1.2005,38(1),33-36. |
| 孙瑞敏等.黄芪多糖的提取.南开大学学报38 1.2005,38(1),33-36. * |
| 李树珍等.黄芪不同提取工艺多糖含量的比较.中草药26 8.1995,26(8),408-410. |
| 李树珍等.黄芪不同提取工艺多糖含量的比较.中草药26 8.1995,26(8),408-410. * |
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Assignee: Hunan Sinoland Biological Pharmaceutical Co., Ltd. Assignor: Tianjin Ruipu Biotechnology Co., Ltd. Contract record no.: 2011120000094 Denomination of invention: Animal medicament with the functioin of curing infectious bronchitis of chicken, and its preparing method Granted publication date: 20110119 License type: Exclusive License Open date: 20070328 Record date: 20110719 |
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Assignee: Hunan Sinoland Biological Pharmaceutical Co., Ltd. Assignor: Tianjin Ringpu Biotechnology Co., Ltd. Contract record no.: 2011120000094 Date of cancellation: 20161216 |
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