CN1927262A - Medicament for animals with heat clearing, dampness eliminating, and diuresis functions and preparing method thereof - Google Patents
Medicament for animals with heat clearing, dampness eliminating, and diuresis functions and preparing method thereof Download PDFInfo
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- CN1927262A CN1927262A CN 200510015054 CN200510015054A CN1927262A CN 1927262 A CN1927262 A CN 1927262A CN 200510015054 CN200510015054 CN 200510015054 CN 200510015054 A CN200510015054 A CN 200510015054A CN 1927262 A CN1927262 A CN 1927262A
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Abstract
The invention involves the field of veterinary medicine technology, particularly in relation to veterinary medicine which takes lysimachia as materials and has the function of clearing away the heat-evil and depriving the evil wetness, promoting diuresis for stranguria and its preparation method. After refining the lysimachia medicinal substances, wash and cut it into pieces, then extract the ground lysimachia: extract it with eight times the weight of water of the medicine, the extraction temperature is 95 +- 3DEG C, accommodate its pH to 2-5 with 10% acid for the first extraction, decocte for 2 hours; still add the water to eight times the weight of the medicine for the second extraction and accommodate its pH to 8-9 with 10% alkali, 1.5 hours extraction. Merge the physic liquor after they are filtrated respectively, after drying, pulverization lysimachia refined powder is obtained, which has good therapeutic effect in treating livestock and poultry diseases. Since the invention technology adopts water extraction, extracting first with acid then with base, the active ingredients of the drug is retained, effective component of the refined powder overcome the difficulty of hard absorption of lysimachia original medicinal substances. Thereby the invention enhances the economic benefits of culture and reduces drug production costs.
Description
Technical field
The invention belongs to the technical field of herbal medicine, the present invention relates to the Chinese crude drug Herba Lysimachiae is the animal medicament and the method for making thereof of a kind of clearing away heat-damp and promoting diuresis of feedstock production, relieving stranguria by diuresis function.
Background technology
Chinese medicine and pharmacy is one of important component part in the cultural treasure-house of China's medicine, and Chinese herbal medicine then is the culture rarity of China.Aspect animal medicine, traditional Chinese veterinary medicine is also playing crucial effect aspect the Clinics and Practices of livestock and poultry.
Along with the scale of livestock and poultry cultivation and the raising of intensification degree; urate deposition in the poultry body that causes by various infectious factors, nutritional disorder's sexual factor and irritability factor etc.; thereby cause diseases such as various nephropathy, edema disease, gout to become puzzlement raiser's a important problem; at present at above-mentioned situation; usually the method that adopts is to use western medicine, generally is that diuretic is treated.Yet along with people to animal food require more and more higher, the sequela that the Western medicine therapy is brought is also more and more serious.High amount of drug is residual in the animal body directly causes the residual of food Chinese medicine to exceed standard, day by day serious to the threat of health of human body.Therefore, in field of veterinary, replace present veterinary drug, become the trend of veterinary drug development with herbal medicine and animal health product.Yet, at present people usually Chinese crude drug through simply being ground into the last poultry of directly feeding, in view of the special physiological structure of poultry, often can not get good absorption, just increased aquaculture cost virtually.(the different name BIANDIXIANG comes from " wishing solemn examination efficacious prescriptions " not retrieve Herba Lysimachiae at present as yet; Marchantia comes from " the wild spectrum of sending relief to a famine area "; Herba Glechomae is come from " interrogating book on Chinese herbal medicine ") application of smart powder on animal.Herba Lysimachiae has eliminating damp-heat, treating stranguria repercussive effect, is commonly used to diseases such as treatment urine is puckeryly had a pain, jaundice dark coloured urine, liver and bile stone at human.And adopt compound preparation usually.Extracting method for Herba Lysimachiae all is the extracting method that adopts the decocting in water precipitate with ethanol at present, this method has been removed the compositions such as protein in the medicine, and generally after carrying, also to adopt in water organic solvents such as ether, chloroform to extract, easily cause residual so in animal body, influence the quality of animal foodstuff, human body is worked the mischief.And said method is higher for the extraction cost of animal drug, and technology is comparatively complicated, and the extraction that is applied to animal drug is also uneconomical.
Summary of the invention
To the objective of the invention is in order addressing the above problem, a kind of smart powder preparation of Herba Lysimachiae with functions such as clearing away heat-damp and promoting diuresis, relieving stranguria by diuresis to be provided.Be used to cure mainly the animal jaundice due to damp-heat, pyretic stranguria, stranguria caused by urinary stone, edema, diseases such as toxic swelling, but mixed feeding also can be mixed the drink administration, and simultaneously again can be as the raw material of further preparation.The Herba Lysimachiae nature and flavor are sweet, salty, be slightly cold, and can go into liver, gallbladder, kidney, urinary bladder channel.And the present invention---gout that the smart powder of Herba Lysimachiae causes for the various causes of disease, lithangiuria, renal calculus etc. can comparatively fast be eliminated symptom, promote body recovery.The smart powder side effect of Herba Lysimachiae is little, the no obvious toxic and side effects in oral back, and do not produce drug resistance after using, body is interior without any drug residue.
Technical scheme of the present invention is: a kind of application and the method for making thereof of the smart powder of Herba Lysimachiae on poultry with clearing away heat-damp and promoting diuresis, relieving stranguria by diuresis function.
The invention provides a kind of have clearing away heat-damp and promoting diuresis, relieving stranguria by diuresis function animal medicament, it is characterized in that this medicament is is the medicament that raw material is made by Herba Lysimachiae.
Dose processing method: Herba Lysimachiae is removed impurity afterwash, cutting, grind then, cross 60 mesh sieves, standby; At first the Herba Lysimachiae after handling is extracted: with the water extraction of 8 times of amounts of medical material, extracting temperature is 95 ± 3 ℃, and being adjusted to pH with 10% acid for the first time is 2-5, decocts 2 hours; Extract for the second time 8 times that will water add to medical material weight, regulating pH with 10% alkali is 8-9, and extraction time is 1.5 hours, and medicinal liquid filters the back merging respectively, and filtrate is concentrated into relative density and is about 1.34-1.36g/cm
370 ℃ thick paste, thick paste carries out vacuum drying, pulverizes; Or merging rear filtrate, to be concentrated into relative density be 1.10-1.20g/cm
370 ℃ clear paste, spray drying promptly get the smart powder of Herba Lysimachiae, and yield is 9.5%-14.1%.
A kind of method for making with animal medicament of clearing away heat-damp and promoting diuresis, relieving stranguria by diuresis function, comprise the Herba Lysimachiae medical material is removed impurity afterwash, cutting, grind then, cross 60 mesh sieves, standby, it is characterized in that at first the Herba Lysimachiae after handling being extracted: with the water extraction of 8 times of amounts of medical material, extracting temperature is 95 ± 3 ℃, for the first time being adjusted to pH with 10% acid is 2-5, decocts 2 hours; Extract for the second time 8 times that will water add to medical material weight, pH is 8-9 with the adjusting of 10% alkali, and extraction time is 1.5 hours; Medicinal liquid filters the back respectively and merges, and promptly gets Herba Lysimachiae extracting solution, and Herba Lysimachiae extracting solution is concentrated into relative density and is about 1.34-1.36g/cm
370 ℃ thick paste, thick paste carries out vacuum drying, pulverizes; Or Herba Lysimachiae extracting solution to be concentrated into relative density be 1.10-1.20g/cm
370 ℃ clear paste, spray drying promptly get the smart powder (yield is 9.5%-14.1%) of Herba Lysimachiae.
Have clearing away heat-damp and promoting diuresis, relieving stranguria by diuresis function animal medicament and a method for making thereof according to described, it is characterized in that described acid is hydrochloric acid or lactic acid; Alkali is to regulate pH value with sodium hydroxide.
Finished product of the present invention can be made multiple dosage form as required, adds appropriate amount of auxiliary materials and can be used as injection, is used for intramuscular injection; Directly medicinal can mixed feeding or mix drink; Carry out breast or intestinal perfusion after also can be water-soluble with powder.
It is respond well to confirm that by clinical experiment this medicine is used for the treatment of the pig calculus of urethra, and experimental result is as follows:
The experiment medicine: the smart powder of Herba Lysimachiae, control drug is that the Herba Lysimachiae decoction pieces is made Christina Loosestrife after crushed.
Laboratory animal: 150 clinical natural occurrences are confirmed as the sick pig of calculus of urethra through animal medicine institute of Agricultural University Of Nanjing pathologic group; Test pig is divided into three groups at random, 50 every group.First group is the smart powder test group of Herba Lysimachiae, and the sick pig after diagnosis is made a definite diagnosis gavages by each 0.1g/kg body weight, connects to drink 5 days.Second group is control medicinal material, and the sick pig after clinical diagnosis is made a definite diagnosis is by every pig of People's Republic of China's veterinary drug allusion quotation recommended dose 15g every day, logotype 5 days.The 3rd group is the chemical medicine group, makes a definite diagnosis every each 0.2g of the oral hydrochlorothiazide in back, every each 0.5～1g of nitrofurantoin, every day 2 times in clinical diagnosis.
The test of the smart treated powder pig of Herba Lysimachiae calculus of urethra
| Group | Experimental animal number (head) | Cure number (head) | Cure rate |
| The smart powder group of Herba Lysimachiae | 50 | 46 | 92％ |
| The control medicinal material group | 50 | 27 | 54％ |
| The chemical medicine group | 50 | 13 | 26％ |
As can be seen from the above table: the smart powder group of Herba Lysimachiae cure rate illustrates that apparently higher than control medicinal material and chemical medicine group this preparation is evident in efficacy.
The invention has the beneficial effects as follows:, confirmed calculus of urethra, jaundice due to damp-heat that the smart treated powder domestic animal of Herba Lysimachiae, poultry cause because of various paathogenic factors, pyretic stranguria by zoopery, stranguria caused by urinary stone, edema, diseases such as toxic swelling have excellent curative, have played the effect of clearing away heat-damp and promoting diuresis, relieving stranguria by diuresis.
Above-mentioned method for making has been broken the traditional human Chinese medicine secondary neutral water extraction or the method for decocting in water precipitate with ethanol, leaching process adopts partly bionical---sour earlier back alkaline extraction, the effective ingredient that has farthest kept Herba Lysimachiae, be particularly suitable for the poultry medication, in leaching process, do not use organic solvent, reduced the step that also will extract organic solvent, avoided the organic solvent residue problem with behind the organic solvent extraction.Protect the effective ingredient in the medicine to greatest extent, reduced production cost.
Confirmed the purposes of the smart powder of Herba Lysimachiae on the treatment livestock and poultry pestilence.Since process using water extraction of the present invention, the method for sour earlier back alkali, water temperature raising degree is higher, has kept the effective ingredient in the medicine, and the active component in the smart powder has overcome the difficult difficulty that absorbs of Herba Lysimachiae crude drug.After water is carried, do not adopt alcohol deposition method, kept the nutritions such as protein in the medicine, after poultry are taken in, help the growth of poultry, thereby improved the economic benefit of culturing, reduced the medicine production cost.Generally speaking reduced aquaculture cost, solved animal food residue problem because of widely applying the chemical drugs treatment to bring.To be used for the treatment of domestic animal, poultry calculus of urethra, gout, renal calculus have excellent curative, played the effect of clearing away heat-damp and promoting diuresis, relieving stranguria by diuresis.
The specific embodiment:
Embodiment 1: depletion money medical herbs material 100kg, with the Herba Lysimachiae raw material wash on request, pick up, cut, dry, pulverized behind 60 mesh sieves standby.Extracting temperature is 95 ± 3 ℃, and amount of water is 8 times of medical material weight for the first time, and with 10% hydrochloric acid solution adjusting pH to 3, extraction time is 2 hours; For the second time amount of water still be 8 times of medical material weight, and with 10% sodium hydroxide solution adjusting pH to 8.5, extraction time is 1 hour.80 ℃ of thickening temperatures, vacuum-0.09Mpa, being concentrated into proportion is 1.20g/cm
3(70 ℃).Spray drying or vacuum decompression crushed after being dried promptly get the smart powder 11.7kg (yield is 11.7%) of Herba Lysimachiae.
Certain chicken house chicken group infects the kidney infectious bronchitis virus, most of chicken group breathes fast, nasal cavity has mucus, coughs, gets rid of head and calls hoarse, appetite descends, drinking-water heightens, the loose stool of the white sample of ash discharge, and sick chicken becomes thin, cuing open the visible kidney enlargement of inspection has a large amount of urate deposition etc., does not see obvious improvement with effect after the chemotherapy of treatment virosis.Adopt medicine of the present invention, 100g converts water 100kg, freely drinks water, carry out five days by a definite date treatment after, most of sick fowl disease close friend changes, symptom disappears substantially, cure rate has reached 93.5%.
Embodiment 2: depletion money medical herbs material 100kg, method for making is with embodiment 1.Can get the smart powder 12.1kg (yield is 12.1%) of Herba Lysimachiae after the extraction.Certain pig farm outburst bowel oedema disease, state of an illness weight differs, and after taking measures to carry out urgent immunity, adds medicine of the present invention, 1g/kg feedstuff, logotype 5 days in feedstuff.Most of sick swine diseases feelings begin to take a turn for the better gradually after 5 days, normal feed of beginning and drinking-water.After continuing to strengthen treatment, be almost recovered.
Claims (3)
1, a kind of have clearing away heat-damp and promoting diuresis, a relieving stranguria by diuresis function animal medicament, it is characterized in that this medicament is is the medicament that raw material is made by Herba Lysimachiae
Dose processing method: Herba Lysimachiae is removed impurity afterwash, cutting, grind then, cross 60 mesh sieves, standby; At first the Herba Lysimachiae after handling is extracted: with the water extraction of 8 times of amounts of medical material, extracting temperature is 95 ± 3 ℃, and being adjusted to pH with 10% acid for the first time is 2-5, decocts 2 hours; Extract for the second time 8 times that will water add to medical material weight, regulating pH with 10% alkali is 8-9, and extraction time is 1.5 hours, and medicinal liquid filters the back merging respectively, and filtrate is concentrated into relative density and is about 1.34-1.36g/cm
370 ℃ thick paste, thick paste carries out vacuum drying, pulverizes; Or filtrate to be concentrated into relative density be 1.10-1.20g/cm
370 ℃ clear paste, spray drying promptly get the smart powder of Herba Lysimachiae, and yield is 9.5%-14.1%.
2, a kind of method for making with animal medicament of clearing away heat-damp and promoting diuresis, relieving stranguria by diuresis function, comprise the Herba Lysimachiae medical material is removed impurity afterwash, cutting, grind then, cross 60 mesh sieves, standby, it is characterized in that at first the Herba Lysimachiae after handling being extracted: with the water extraction of 8 times of amounts of medical material, extracting temperature is 95 ± 3 ℃, for the first time being adjusted to pH with 10% acid is 2-5, decocts 2 hours; Extract for the second time 8 times that will water add to medical material weight, pH is 8-9 with the adjusting of 10% alkali, and extraction time is 1.5 hours; Medicinal liquid filters the back respectively and merges, and promptly gets Herba Lysimachiae extracting solution, and Herba Lysimachiae extracting solution is concentrated into relative density and is about 1.34-1.36g/cm
370 ℃ thick paste, thick paste carries out vacuum drying, pulverizes; Or filtrate to be concentrated into relative density be 1.10-1.20g/cm
370 ℃ clear paste, spray drying promptly get the smart powder of Herba Lysimachiae, and yield is 9.5%-14.1%.
3, describedly have clearing away heat-damp and promoting diuresis, relieving stranguria by diuresis function animal medicament and a method for making thereof according to claim 1 and 2, it is characterized in that described acid is hydrochloric acid or lactic acid; Alkali is to regulate pH value with sodium hydroxide.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200510015054 CN1927262A (en) | 2005-09-09 | 2005-09-09 | Medicament for animals with heat clearing, dampness eliminating, and diuresis functions and preparing method thereof |
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| CN 200510015054 CN1927262A (en) | 2005-09-09 | 2005-09-09 | Medicament for animals with heat clearing, dampness eliminating, and diuresis functions and preparing method thereof |
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| CN1927262A true CN1927262A (en) | 2007-03-14 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103330074A (en) * | 2013-06-23 | 2013-10-02 | 李其珍 | Feed for growing and fattening pigs |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103330074A (en) * | 2013-06-23 | 2013-10-02 | 李其珍 | Feed for growing and fattening pigs |
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