CN106617038A - Health-care food composition for relieving male frequent urination and urinary incontinence as well as preparation method and application of health-care food composition - Google Patents
Health-care food composition for relieving male frequent urination and urinary incontinence as well as preparation method and application of health-care food composition Download PDFInfo
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Abstract
The invention discloses a health-care food composition for relieving male frequent urination and urinary incontinence as well as a preparation method and application of the health-care food composition, belonging to the technical field of health-care food. The composition is prepared from the following raw material components in parts by weight: 5 to 20 parts of rape flower powder, 2 to 5 parts of cushaw fruit seed, 2 to 5 parts of club bottle gourd fruit seed and 0.5 to 3 parts of fructus psoraleae extract; or the composition is prepared from 5 to 20 parts of the rape flower powder, 0.4 to 5 parts of cushaw fruit seed oil, 0.4 to 4 parts of cushaw fruit seed water extract, 0.4 to 5 parts of club bottle gourd fruit seed oil, 0.4 to 4 parts of club bottle gourd fruit seed water extract, 0.0175 to 0.0702 part of zinc gluconate, 0.5 to 3 parts of the fructus psoraleae extract and 0.5 to 3 parts of seminis juglantis septum water extract. By adopting a unique extraction method, the health-care food composition disclosed by the invention has the advantages of high use rate of effective components, less waste, good effect and no toxic or side effect.
Description
Technical field
The present invention relates to health-care food composition, more particularly to a kind of health care food for improving male sex's frequent micturition, the urinary incontinence
Product composition, with and its preparation method and application, belong to technical field of health care food.
Background technology
Occurred frequently due to prostatic disorders, each state has all carried out the research and development of such medicine, wherein mainly treating prostate
Based on the medicine of disease, its medication mainly has " Proscar " of Mo Shadong pharmacy, " Harnal " of Yamanouchi pharmacy and Pfizer
" can more China ".Prostatitis and hyperplasia of prostate are mainly treated using Chinese patent drug, and principal item has the U.S. auspicious " house in Nanjing
Buddhist nun is led to ", " Qian Lie Kang " of Kang Enbei, " urine is logical " of Evers (Germany), " Cystocaps " of Fink (Germany) etc..And health food
Because not improving prostate this function, in the market like product is fewer.Although conventional medicament improves prostate disease
Disease symptoms are obvious, but long-term consumption has potential toxicity, as the pharmacological effect mechanism of new resource food is constantly sent out
Existing, people are increasingly intended to apply natural component, China to possess rich in natural resources, and their drug effect and security is clear and definite.Cause
This, finding natural, efficient natural material becomes a kind of inexorable trend.
The traditional Chinese medical science thinks, the main water of kidney, the kidney dominating he two YIN-orifices, and main two just, exterior and interior relation between kidney and bladder, the folding of bladder and the excretion of urine
It is relevant, and the folding of bladder, the gasification of kidney is depended on, the gasification of kidney is normal, then bladder folding is normal, and turbid liquid must be let out, if kidney
Gasification often, then affects the folding of bladder, causes bladder folding unfavorable, and sees the diseases such as oliguria, oedema；Or cause bladder to constrain nothing
Power, and see the diseases such as diuresis, the enuresis.The prosperity and decline of kidney qi, directly affects the gasification and folding of bladder, causes bladder folding unfavorable or leads
Cause bladder constraint to have no right, and see the diseases such as diuresis, the enuresis.
Frequent micturition, the urinary incontinence are one of common clinical diseases of middle Laonan's property.The urinary incontinence is exactly unconscious urination.If bladder
Internal pressure exceedes the pressure that closing urethra needs, and the non-controlling urinary incontinence will occur.It is the common sympton of urination disorder illness,
Substantially it is the performance of bladder storage dysfunction, is not an independent disease.But often have influence on the normal life of patient
It is living, reduce the quality of life of patient, especially night urination number of times increases, and has a strong impact on patient sleeps, in addition can cause anxiety and
It is depressed, it is also possible to increase cardiovascular and cerebrovascular disease probability of happening.
Prostate is genital orgnas,male, and the region of anatomy is special, medicine be difficult into and to around spreading, integrative therapy
Feel very thorny.At present in addition to physical treatment, massage of prostate, drug therapy is indispensable.Medicine bag
Include antibiotic, alpha-blocking agent, 5 alpha reductase inhibitors, non-steroidal anti-inflammatory agent etc., although medicine is varied, but treat
Effect is not satisfactory, can only suppress to eradicate, and recurrence rate is higher, and western medicine all has certain side effect, original used
Material expensive and its preparation method complexity.The maintenance of development and physiological status that scripture offers inquiry prostate is depended on to be had in vivo
The balance of enough male sex hormones, especially male sex hormone and female hormone, and the pathogenesis of hypertrophy of the prostate and endocrine
System fading margin is relevant with control imbalance.The several amino acids of contained glutamic acid, proline etc. 20 in rape pollen, can improve prostatitis
The blood circulation of glandular tissue, mitigates oedema, alleviates the urethremphraxis that hypertrophy of the prostate causes.Flavonoid substances therein have very
Strong anti-oxidation function, is also the jinx of hyperplasia of prostate.There is flavonols in pollen anti arteriosclerosis, reducing blood lipid and courage to consolidate
Alcohol, analgesia, radioresistance, the treatment effect such as constipation, to prostatitic therapeutic efficiency up to 90%, and can prevent hypertrophy of the prostate,
Prostatic function is disorderly, can also treat varicose ulcer.Rape pollen can strengthen capillary intensity, and reduction blood fat is right
Treatment diabetes, anaemia, constipation, cancer-resisting etc. are all effective in cure.Recent study finds that pumpkin and pepo also can use
To treat the disease in the urological system related to benign prostatauxe (BPH).
Therefore, the present invention studies prostatitis and the hyperplasia of prostate cause of disease interpretation of the cause, onset and process of an illness on the basis of diagnosis and treatment, to improve
For the purpose of male sex's frequent micturition, the urinary incontinence, the theoretical research and the actual efficacy research of each raw material of Jing foundation modern pharmacology drug effects are selected
Going out to have improves male sex's frequent micturition, the raw material of the health food of the urinary incontinence and has the natural extraction such as rape pollen, pumpkin, pepo
Thing, safety non-toxic is aided with other medicinal materials and heightens the effect of a treatment, and is the day for improving the symptom best results such as male sex's frequent micturition, urinary incontinence
Right raw material.The present inventor is by experiment again and again, summary and improves, the technical side of the present invention under finally determining
Case, and achieve ideal therapeutic effect.
A kind of possible technical scheme：It is a kind of to improve male sex's frequent micturition, the health-care food composition of the urinary incontinence and its application, its
It is characterised by：It is made up of following raw materials according component：5～20 parts of rape pollen, 5～10 parts of pumpkin.By choose pumpkin with
Rape pollen acts synergistically.Processing method：Rape pollen is first cured and crushed afterwards using high-temperature sterilization process, pumpkin, incite somebody to action the two
Make powder after crushing in proportion.
Shortcoming：1st, high-temperature sterilization easily breaks the activity of ring rape pollen.2nd, composition is single.
A kind of possible technical scheme：It is a kind of to improve male sex's frequent micturition, the health-care food composition of the urinary incontinence and its application, its
It is characterised by：It is made up of following raw materials according component：10～15 parts of rape pollen, 2～10 parts of pumpkin seed oil, pepo oil 2～
10 parts, 0.0175～0.0702 part of zinc gluconate.Processing method：Rape pollen is using high-temperature sterilization process, pumpkin, western calabash
Reed seed obtains pumpkin seed oil and pepo oil using " directly squeezing " method.
Shortcoming：1st, high-temperature sterilization easily breaks the activity of ring rape pollen.2nd, direct expression technological operation is simple, production sets
It is standby can letter can numerous, production scale flexible in size, it is adaptable to the production of each vegetable oil, but milling process has oil yield low, labor
Power is big, the shortcoming of low production efficiency.3rd, the cake after extracting oil preferably is not utilized, and wastes the energy.
The content of the invention
It is an object of the invention to provide can be used to improve male sex's frequent micturition, the health-care food composition of the urinary incontinence and its preparation
Methods and applications.
In order to achieve the above object, present invention employs following technological means：
The present invention provides a kind of health-care food composition for improving male sex's frequent micturition, the urinary incontinence, by following parts by weight
Bulk drug make：5～20 parts of rape pollen, 2～5 parts of pumpkin, 2～5 parts of pepo, Fructus Psoraleae extract 0.5～3
Part；Preferably, it is made up of the bulk drug of following parts by weight：10 parts of rape pollen, 2.5 parts of pumpkin, 2.5 parts of pepo,
1.5 parts of Fructus Psoraleae extract.
Further, the invention provides for the preparation method of above-mentioned health-care food composition, comprising the following steps：
(1) sterilize
Rape pollen is carried out into sterilization treatment, then be dry, pulverize, sieved, obtain material A, it is standby；
(2) cure
Crush after pumpkin, pepo are cured, sieve, respectively obtain material B, C, it is standby；
(3) ultra high pressure extraction
Psoralea corylifolia is extracted using ultrahigh-pressure extraction method, Fructus Psoraleae extract is obtained, filtration is evaporated, crushes, and obtains material D,
It is standby；
(4) mix
Tetra- kinds of materials of A, B, C, D are weighed by formula, is well mixed, obtained final product.
Wherein, it is preferred that sterilization treatment described in step (1) is low temperature sterilization process；The drying is low temperature drying；Institute
State and sieve to cross 80～100 mesh sieves.
Wherein, it is preferred that sieve described in step (2) to cross 80～100 mesh sieves.
Wherein, it is preferred that the extraction pressure of ultrahigh-pressure extraction method described in step (3) is 100Mpa, extract is
The ethanol of 60vt%, solvent and solute weight ratio are 90：1.
The present invention also provides another kind of health-care food composition for improving male sex's frequent micturition, the urinary incontinence, by following weight
The bulk drug of number is made：5～20 parts of rape pollen, 0.4～5 part of pumpkin seed oil, 0.4～4 part of pumpkin water extract, western calabash
0.4～5 part of reed seed oil, 0.4～4 part of pepo water extract, 0.0175～0.0702 part of zinc gluconate, Psoralea corylifolia is extracted
0.5～3 part of thing, 0.5～3 part of diaphragma juglandis water extract；Preferably, it is made up of the bulk drug of following parts by weight：Rape pollen
10 parts, 2.5 parts of pumpkin seed oil, 2.5 parts of pumpkin water extract, 2.5 parts of pepo oil, 2.5 parts of pepo water extract,
0.0351 part of zinc gluconate, 1.5 parts of Fructus Psoraleae extract, 1.5 parts of diaphragma juglandis water extract.
Further, the invention provides for the preparation method of above-mentioned health-care food composition, comprising the following steps：
(1) sterilize
Rape pollen is carried out into sterilization treatment, then be dry, pulverize, sieved, obtain material A, it is standby；
(2) cold press is extracted
Pumpkin is peeled off, and takes seed benevolence, and pumpkin seed is extracted oil, and obtains pumpkin seed oil, i.e. material B, and the pumpkin after squeezing
Seedcake, it is standby；
Pepo is peeled off, and takes seed benevolence, by the oil expression of pepo benevolence, obtains pepo oil, i.e. after material C, and squeezing
Cucurbita pepo seedcake, it is standby；
(3) water extraction
Pumpkin seedcake after squeezing, cucurbita pepo seedcake and diaphragma juglandis are respectively adopted into water extraction method to be extracted, are filtered, it is dense
Contracting, is dried, and respectively obtains pumpkin water extract D, pepo water extract E and diaphragma juglandis water extract F, standby；
(4) ultra high pressure extraction
Psoralea corylifolia is extracted using ultrahigh-pressure extraction method, Fructus Psoraleae extract is obtained, filtration is evaporated, crushes, and obtains material G,
It is standby；
(5) mix
Seven kinds of materials of A-G and zinc gluconate are weighed according to formula, is well mixed, pelletized, obtained final product.
Wherein, it is preferred that sterilization treatment described in step (1) is low temperature sterilization process；The drying is low temperature drying；Institute
State and sieve to cross 80～100 mesh sieves.
Wherein, it is preferred that pumpkin seed extracts oil described in step (2) be to carry out cold press, adjustment oil expression using oil press
Machine press chamber temperature 70 C, pressure 3.5Mpa, rotating speed 36r/min, 3-4 time repeatedly.
Wherein, it is preferred that pepo benevolence is extracted oil described in step (2) be to carry out cold press using oil press, and adjustment is squeezed
80 DEG C of oil machine press chamber temperature, pressure 3.6Mpa, rotating speed 36r/min, 3-4 time repeatedly.
Wherein, it is preferred that the Extracting temperature that water described in step (3) is extracted is 100 DEG C, extraction time is 1 hour, feed liquid
Weight ratio is 1：10～1：20.
Wherein, it is preferred that the extraction pressure of ultrahigh-pressure extraction method described in step (4) is 100Mpa, extract is
The ethanol of 60vt%, solvent and solute weight ratio are 90：1.
The health-care food composition of the present invention can be used to prepare the health food for improving male sex's frequent micturition, the urinary incontinence.
The function of each component is as follows in inventive formulation：
Rape pollen：Rape is the agricultural economy crop of China's establishing in large scale, and powder source is wide, adopts northern crop rape flower,
Quality is pure, and rape pollen nutriment enriches, rape kidney-nourishing, consolidate, strong waist, and alcohol containing brass is higher, with anti-artery
Atherosis, treatment varicose ulcer, reduction cholesterol and radiation-resistant effect, there is significantly treatment to chronic prostatitis
Effect.
Pumpkin：Pumpkin (cucurbita moschata Duch.), another name pumpkin, meal melon etc., are that Curcurbitaceae is annual
Herbaceous plant.The nutritive value of pumpkin is very high, except containing the nutrition such as various free amino acids, carotene, VB, VC, mannitol into
Exceptionally, also containing multiple efficacies composition, domestic more to the research of pumpkin, the research to pumpkin is started late.Pumpkin is
The mature seed of pumpkin, it contains abundant unrighted acid, vitamin, biological flavone, squash polyoses and mineral matter etc., this
A little functional components have extensive and important biological function, with preferably research and using value.Pumpkin seed oil is from complete
The grease extracted in complete ripe pumpkin, in natural bottle green, salubrious non-greasy, there is a nutty, rich in nutrition content,
It is can to provide one of desired nutritional material and the higher nutritional oil of content to human body.Pumpkin seed oil be pumpkin through squeezing or
Extracting method is obtained, wherein containing oleic acid, linoleic acid, leukotrienes, palmitic acid, stearic acid, arachidic acid, watt gram a kind of reed mentioned in ancient books acid, erucic acid etc.
Unrighted acid, total unrighted acid accounts for the 74.9% of fatty acid total amount, and oleic acid therein, linoleic acid content account for pumpkin
The 35%～50% of seed dry weight.With polyunsaturated fatty acid (PUFA) as main component in unrighted acid；In pumpkin seed oil
Also containing abundant vitamin, such as fat-soluble VE, also containing a certain amount of phylloquinone-vitamin K；Mineral in pumpkin seed oil
Matter content very abundant, wherein zinc, magnesium, iron, selenium etc. have special biological effectiveness.Especially, plant steroid contained therein
Alcohol, can treat the disease in the urological system symptom of patient BPH, and in traditional medicine, its seed is used as antihelmintic, demulcen, diuresis
Agent and tonic, with a plant tea made by its seed hypertrophy of the prostate can be treated.It can be seen that pumpkin is in field of health care food
There is good development prospect.
Pepo：Cucurbita pepo (Cucurbita pepo L.) also known as Cucurbita aurantia Willd.,
Cucurbita melopepo L.Pepo vulgaris Moench.Early in the edible cucurbita pepo of the existing ancients of Christian era century
Record, from that time, in countries such as China, be just known.Successive dynasties, medicine scholar unanimously generally acknowledged that it has six functionses：
Nourishing beauty, mental-tranquilization, stomach invigorating moistening lung, antibacterial salubrity, relax bowel, the wide chest of profit pressure.In addition, it may also be used for auxiliary treatment water
The disease such as swollen abdominal distension, polydipsia, sore and ephritis, cirrhotic ascites.In traditional medicine, its seed be used as antihelmintic, demulcen,
Diuretics and tonic, with a plant tea made by its seed hypertrophy of the prostate can be treated.Cucurbita pepo seed is used at present
The example of the treatment disease in the urological system related to benign prostatauxe (BPH).The main component of pepo is plant steroid
Alcohol, reactive compound is Δ 5, Δ 7 and Δ 8- sterols, and wherein Δ 7- sterols are high in cucurbitae semina content, it is considered to be controlled
The key active ingredients in benign prostate hyperplasia are treated, a small amount of Δ 5, Δ 8- sterols similarly exist in cucurbitae semina and rise
Effect, the carotenoid of high-load, polyunsaturated fatty acid and liposoluble vitamin also have certain active function, can treat
The disease in the urological system symptom of patient BPH, there is good development prospect in field of health care food.19 end of the centurys, pepo
Oil just be used to treat urinary tract illness.Zooscopy shows that cucurbita pepo seed water extract may improve the work(of bladder and urethra
Energy.
Psoralea corylifolia：Psoralea corylifolia is the drying and ripening fruit of legumes psoraleae (Psoralea coryli-folia L.)
It is real, begin to be loaded in《Thunder God big gun moxibustion opinion》, there is tonify the kidney and support yang, receive gas, antidiarrheal.The successive dynasties traditional Chinese medical science is used for kidney deficiency, cold rush down, loses cunning
The symptoms such as essence, frequent urination, waist and knee crymodynia.
Diaphragma juglandis：Diaphragma juglandis is the wooden barrier film in juglandaceae plant English walnut (Juglans regia L.) fruit stone, also known as
English walnut clothing, cracker, English walnut are every, walnut barrier film.The traditional Chinese medical science thinks that this product nature and flavor are bitter, puckery, flat, enters spleen, kidney channel, have invigorating the spleen to reinforce the kidney,
Diuresis heat-clearing, the effects such as control gonorrhoea hematuria, hot summer weather rush down dysentery, it is adaptable to treatment lose drown, blood, deafness under metrorrhagia, control seminal emission, frequent micturition,
With inferior.Drunk with walnut diaphragma juglandis is soaked, the function with the puckery essence of kidney tonifying is burst to hidrosis, frequent micturition, the enuresis, emission due to the kidney deficiency, oral cavity
Ulcer, bleeding gums, urine are many etc. also powerful, and with certain antibacterial activity.
Zinc gluconate：Zinc is present in numerous enzyme systems, such as carbonic anhydrase, respiratory enzyme, LDH, superoxides
It is nucleic acid, protein, the synthesis of carbohydrate and vitamin A during mutase, alkaline phosphatase, DNA and RNA are poly- in enzyme etc.
Utilization institute it is required.The proper constituent and functional unit of zinc or cortex hormone of aadrenaline, the content of zinc exceedes it in prostate
10 times of his organ, the hyperplasia of prostate is relevant with zinc deficiency.
Bulk drug used in the present invention meets Quality Standards of Health Foods requirement.
Compared to prior art, the beneficial effects of the present invention is：
One and preparation method thereof (5～20 parts of rape pollen, 2～5 parts of pumpkin, 2～5 parts of pepo, Psoralea corylifolia of formula
0.5～3 part)：This health-care food composition on the basis of rape pollen is combined with pumpkin and is improved prostatic diseases, more
Addition is acted synergistically from pepo with pumpkin, and adds Fructus Psoraleae extract increase curative effect, can be effectively improved male urine
Frequently, the symptom of the urinary incontinence；Additionally, its unique preparation method for adopting further enhancing the health-care efficacy of this food, for example：
Low temperature sterilization employed in step (2) ensure that the form and vigor of rape pollen；Super-pressure employed in step (4)
Extracting method extracts Psoralea corylifolia, and psoralen is obtained to the full extent；Feed preparation process is easy, easy to operate, makes powder trouble
Person can directly take after mixing it with water, taking convenience.
Two and preparation method thereof (5～20 parts of rape pollen, 0.4～5 part of pumpkin seed oil, pumpkin water extracts 0.4 of formula
～4 parts, 0.4～5 part of pepo oil, 0.4～4 part of pepo water extract, 0.0175～0.0702 part of zinc gluconate,
0.5～3 part of Psoralea corylifolia, 0.5～3 part of diaphragma juglandis)：On the basis of formula one, pumpkin and pepo are processed further
For seed oil and water extract so as to which active ingredient can preferably be absorbed by the body；The zinc gluconate of addition and divert one's attention simultaneously
Wood is also further enhanced to the curative effect of this health-care food composition.Additionally, its unique preparation method for adopting enters one
Step enhances the health-care efficacy of this food, for example：Low temperature sterilization employed in step (2) ensure that the form of rape pollen
And vigor；Step (3) obtains pumpkin seed oil and pepo oil using " cold-press ", while higher oil yield efficiency is ensured,
The trace nutrient in seed oil can be retained again；Step (4) further obtains the seedcake after squeezing effectively with water extracting method
Material, makes full use of raw material, and waste is preferably minimized；Psoralea corylifolia superhigh pressure extracting method employed in step (5), maximum journey
The recovery rate of psoralen is improved on degree, tablet is made after all substances are mixed and is facilitated patient to take, make full use of material, reached
To therapeutic effect.
The present invention studies male sex's frequent micturition, the pathogenesis of the urinary incontinence, selected raw material, using only on the basis of diagnosis and treatment
Prepared by special extracting method has the health food for improving prostatic disorders, and active ingredient utilization rate is high, and the little, effect of waste is good, nothing
Any toxic and side effect.After to a series of process of raw material, material is mixed and made into powder or tablet is more conducive to patient and takes,
And achieve ideal therapeutic effect.
Specific implementation method
Further describe the present invention with reference to concrete comparative example and embodiment, advantages of the present invention and feature will be with
Description and it is apparent.But these embodiments are only exemplary, do not constitute any restriction to the scope of the present invention.Ability
Field technique personnel should be understood that without departing from the spirit and scope of the invention can be to the details of technical solution of the present invention
Modify with form or replace, but these modifications and replacement are each fallen within protection scope of the present invention.
Comparative example 1
(1) sterilize
By rape pollen low temperature sterilization, then low temperature drying, crush, cross 100 mesh sieves, obtain material A, it is standby；
(2) cure
Crush after pumpkin is cured, cross 100 mesh sieves, obtain material B, it is standby；
(3) mix
10g material As, 5g material B are weighed by formula ratio, is well mixed, obtained final product.
Comparative example 2
(1) sterilize
By rape pollen low temperature sterilization, then low temperature drying, crush, cross 100 mesh sieves, obtain material A, it is standby；
(2) cure
Crush after pumpkin, pepo are cured, cross 100 mesh sieves, respectively obtain material B, C, it is standby；
(3) mix
10g material As, 2.5g material B, 2.5g material C are weighed by formula ratio, is well mixed, obtained final product.
Embodiment 1
(1) sterilize
By rape pollen low temperature sterilization, then low temperature drying, crush, cross 100 mesh sieves, obtain material A, it is standby；
(2) cure
Crush after pumpkin, pepo are cured, cross 100 mesh sieves, respectively obtain material B, C, it is standby；
(3) ultra high pressure extraction
Psoralea corylifolia is extracted using ultrahigh-pressure extraction method, it is that the ethanol of 60vt%, liquid are solid that extractions pressure is 100Mpa, extract
Weight ratio is 90：1, Fructus Psoraleae extract is obtained, filtration is evaporated, crushes, and obtains material D, standby；
(4) mix
5g material As, 4.25g material B, 4.25g material C, 3g material D are weighed by formula ratio, is well mixed, obtained final product.
Embodiment 2
(1) sterilize
By rape pollen low temperature sterilization, then low temperature drying, crush, cross 100 mesh sieves, obtain material A, it is standby；
(2) cure
Crush after pumpkin, pepo are cured, cross 100 mesh sieves, respectively obtain material B, C, it is standby；
(3) ultra high pressure extraction
Psoralea corylifolia is extracted using ultrahigh-pressure extraction method, it is that the ethanol of 60vt%, liquid are solid that extractions pressure is 100Mpa, extract
Weight ratio is 90：1, Fructus Psoraleae extract is obtained, filtration is evaporated, crushes, and obtains material D, standby；
(4) mix
12g material As, 2g material B, 2g material C, 0.5g material D are weighed by formula ratio, is well mixed, obtained final product.
Embodiment 3
(1) sterilize
By rape pollen low temperature sterilization, then low temperature drying, crush, cross 100 mesh sieves, obtain material A, it is standby；
(2) cure
Crush after pumpkin, pepo are cured, cross 100 mesh sieves, respectively obtain material B, C, it is standby；
(3) ultra high pressure extraction
Psoralea corylifolia is extracted using ultrahigh-pressure extraction method, it is that the ethanol of 60vt%, liquid are solid that extractions pressure is 100Mpa, extract
Weight ratio is 90：1, Fructus Psoraleae extract is obtained, filtration is evaporated, crushes, and obtains material D, standby；
(4) mix
10g material As, 2.5g material B, 2.5g material C, 1.5g material D are weighed by formula ratio, is well mixed, obtained final product.
Comparative example 3
(1) sterilize
By rape pollen low temperature sterilization, then low temperature drying, crush, cross 100 mesh sieves, obtain material A, it is standby；
(2) cold press is extracted
Pepo is peeled off, and takes seed benevolence, and pepo benevolence is carried out into cold press using oil press, adjusts oil extruder bore temperature
80 DEG C, pressure 3.6Mpa, rotating speed 36r/min, 4 times repeatedly, obtain pepo oil, i.e. material B, and squeeze after pepo
Cake, it is standby；
(3) water extraction
Cucurbita pepo seedcake after squeezing is extracted using water extraction method, Extracting temperature is 100 DEG C, extraction time is 1 little
When, feed liquid weight ratio be 1：10, to filter, concentration is dried, and respectively obtains pumpkin water extract C, standby；
(4) mix
10g material As, 5g material B, 5g material C, 0.0351g zinc gluconates are weighed by formula ratio, are well mixed, pelletized,
Obtain final product.
Comparative example 4
(1) sterilize
By rape pollen low temperature sterilization, then low temperature drying, crush, cross 100 mesh sieves, obtain material A, it is standby；
(2) cold press is extracted
Pumpkin is peeled off, and takes seed benevolence, and pumpkin seed is carried out into cold press, adjustment oil extruder bore temperature 70 using oil press
DEG C, pressure 3.5Mpa, rotating speed 36r/min, 4 times repeatedly, obtain pumpkin seed oil, i.e. material B, and the pumpkin seedcake after squeezing, it is standby
With；
Pepo is peeled off, and takes seed benevolence, and pepo benevolence is carried out into cold press using oil press, adjusts oil extruder bore temperature
80 DEG C, pressure 3.6Mpa, rotating speed 36r/min, 4 times repeatedly, obtain pepo oil, i.e. material C, and squeeze after pepo
Cake, it is standby；
(3) water extraction
Pumpkin seedcake and cucurbita pepo seedcake after squeezing is respectively adopted into water extraction method to be extracted, Extracting temperature be 100 DEG C,
Extraction time be 1 hour, feed liquid weight ratio be 1：10, to filter, concentration is dried, and respectively obtains pumpkin water extract D and western calabash
Reed seed water extract E, it is standby；
(4) mix
10g material As, 2.5g material B, 2.5g material C, 2.5g material D, 2.5g material E, 0.0351g are weighed by formula ratio
Zinc gluconate, is well mixed, granulation, obtains final product.
Comparative example 5
(1) sterilize
By rape pollen low temperature sterilization, then low temperature drying, crush, cross 100 mesh sieves, obtain material A, it is standby；
(2) cold press is extracted
Pumpkin is peeled off, and takes seed benevolence, and pumpkin seed is carried out into cold press, adjustment oil extruder bore temperature 70 using oil press
DEG C, pressure 3.5Mpa, rotating speed 36r/min, 4 times repeatedly, obtain pumpkin seed oil, i.e. material B, and the pumpkin seedcake after squeezing, it is standby
With；
Pepo is peeled off, and takes seed benevolence, and pepo benevolence is carried out into cold press using oil press, adjusts oil extruder bore temperature
80 DEG C, pressure 3.6Mpa, rotating speed 36r/min, 4 times repeatedly, obtain pepo oil, i.e. material C, and squeeze after pepo
Cake, it is standby；
(3) water extraction
Pumpkin seedcake after squeezing, cucurbita pepo seedcake and diaphragma juglandis are respectively adopted into water extraction method to be extracted, Extracting temperature
For 100 DEG C, extraction time be 1 hour, feed liquid weight ratio be 1：10, to filter, concentration is dried, and respectively obtains the extraction of pumpkin water
Thing D, pepo water extract E and diaphragma juglandis water extract F, it is standby；
(4) mix
By formula weigh 10g material As, 2.5g material B, 2.5g material C, 2.5g material D, 2.5g material E, 3g material F,
0.0351g zinc gluconates, are well mixed, granulation, obtain final product.
Comparative example 6
(1) sterilize
By rape pollen low temperature sterilization, then low temperature drying, crush, cross 100 mesh sieves, obtain material A, it is standby；
(2) cold press is extracted
Pumpkin is peeled off, and takes seed benevolence, and pumpkin seed is carried out into cold press, adjustment oil extruder bore temperature 70 using oil press
DEG C, pressure 3.5Mpa, rotating speed 36r/min, 4 times repeatedly, obtain pumpkin seed oil, i.e. material B, and the pumpkin seedcake after squeezing, it is standby
With；
Pepo is peeled off, and takes seed benevolence, and pepo benevolence is carried out into cold press using oil press, adjusts oil extruder bore temperature
80 DEG C, pressure 3.6Mpa, rotating speed 36r/min, 4 times repeatedly, obtain pepo oil, i.e. material C, and squeeze after pepo
Cake, it is standby；
(3) water extraction
Pumpkin seedcake and cucurbita pepo seedcake after squeezing is respectively adopted into water extraction method to be extracted, Extracting temperature be 100 DEG C,
Extraction time be 1 hour, feed liquid weight ratio be 1：10, to filter, concentration is dried, and respectively obtains pumpkin water extract D and western calabash
Reed seed water extract E, it is standby；
(4) ultra high pressure extraction
Psoralea corylifolia is extracted using ultrahigh-pressure extraction method, it is that the ethanol of 60vt%, liquid are solid that extractions pressure is 100Mpa, extract
Weight ratio is 90：1, Fructus Psoraleae extract is obtained, filtration is evaporated, crushes, and obtains material F, standby；
(5) mix
By formula weigh 10g material As, 2.5g material B, 2.5g material C, 2.5g material D, 2.5g material E, 3g material F,
0.0351g zinc gluconates, are well mixed, granulation, obtain final product.
Embodiment 4
(1) sterilize
By rape pollen low temperature sterilization, then low temperature drying, crush, cross 100 mesh sieves, obtain material A, it is standby；
(2) cold press is extracted
Pumpkin is peeled off, and takes seed benevolence, and pumpkin seed is carried out into cold press, adjustment oil extruder bore temperature 70 using oil press
DEG C, pressure 3.5Mpa, rotating speed 36r/min, 4 times repeatedly, obtain pumpkin seed oil, i.e. material B, and the pumpkin seedcake after squeezing, it is standby
With；
Pepo is peeled off, and takes seed benevolence, and pepo benevolence is carried out into cold press using oil press, adjusts oil extruder bore temperature
80 DEG C, pressure 3.6Mpa, rotating speed 36r/min, 4 times repeatedly, obtain pepo oil, i.e. material C, and squeeze after pepo
Cake, it is standby；
(3) water extraction
Pumpkin seedcake after squeezing, cucurbita pepo seedcake and diaphragma juglandis are respectively adopted into water extraction method to be extracted, Extracting temperature
For 100 DEG C, extraction time be 1 hour, feed liquid weight ratio be 1：10, to filter, concentration is dried, and respectively obtains the extraction of pumpkin water
Thing D, pepo water extract E and diaphragma juglandis water extract F, it is standby；
(4) ultra high pressure extraction
Psoralea corylifolia is extracted using ultrahigh-pressure extraction method, it is that the ethanol of 60vt%, liquid are solid that extractions pressure is 100Mpa, extract
Weight ratio is 90：1, Fructus Psoraleae extract is obtained, filtration is evaporated, crushes, and obtains material G, standby；
(5) mix
14g material As, 2g material B, 2g material C, 2g material D, 2g material E, 0.5g material F, 0.5g materials are weighed by formula
G, 0.0175g zinc gluconate, is well mixed, granulation, obtains final product.
Embodiment 5
(1) sterilize
By rape pollen low temperature sterilization, then low temperature drying, crush, cross 100 mesh sieves, obtain material A, it is standby；
(2) cold press is extracted
Pumpkin is peeled off, and takes seed benevolence, and pumpkin seed is carried out into cold press, adjustment oil extruder bore temperature 70 using oil press
DEG C, pressure 3.5Mpa, rotating speed 36r/min, 4 times repeatedly, obtain pumpkin seed oil, i.e. material B, and the pumpkin seedcake after squeezing, it is standby
With；
Pepo is peeled off, and takes seed benevolence, and pepo benevolence is carried out into cold press using oil press, adjusts oil extruder bore temperature
80 DEG C, pressure 3.6Mpa, rotating speed 36r/min, 4 times repeatedly, obtain pepo oil, i.e. material C, and squeeze after pepo
Cake, it is standby；
(3) water extraction
Pumpkin seedcake after squeezing, cucurbita pepo seedcake and diaphragma juglandis are respectively adopted into water extraction method to be extracted, Extracting temperature
For 100 DEG C, extraction time be 1 hour, feed liquid weight ratio be 1：10, to filter, concentration is dried, and respectively obtains the extraction of pumpkin water
Thing D, pepo water extract E and diaphragma juglandis water extract F, it is standby；
(4) ultra high pressure extraction
Psoralea corylifolia is extracted using ultrahigh-pressure extraction method, it is that the ethanol of 60vt%, liquid are solid that extractions pressure is 100Mpa, extract
Weight ratio is 90：1, Fructus Psoraleae extract is obtained, filtration is evaporated, crushes, and obtains material G, standby；
(5) mix
5g material As, 3.5g material B, 3.5g material C, 3.5g material D, 3.5g material E, 2g material F, 2g are weighed by formula
Material G, 0.0702g zinc gluconate, is well mixed, granulation, obtains final product.
Embodiment 6
(1) sterilize
By rape pollen low temperature sterilization, then low temperature drying, crush, cross 100 mesh sieves, obtain material A, it is standby；
(2) cold press is extracted
Pumpkin is peeled off, and takes seed benevolence, and pumpkin seed is carried out into cold press, adjustment oil extruder bore temperature 70 using oil press
DEG C, pressure 3.5Mpa, rotating speed 36r/min, 4 times repeatedly, obtain pumpkin seed oil, i.e. material B, and the pumpkin seedcake after squeezing, it is standby
With；
Pepo is peeled off, and takes seed benevolence, and pepo benevolence is carried out into cold press using oil press, adjusts oil extruder bore temperature
80 DEG C, pressure 3.6Mpa, rotating speed 36r/min, 4 times repeatedly, obtain pepo oil, i.e. material C, and squeeze after pepo
Cake, it is standby；
(3) water extraction
Pumpkin seedcake after squeezing, cucurbita pepo seedcake and diaphragma juglandis are respectively adopted into water extraction method to be extracted, Extracting temperature
For 100 DEG C, extraction time be 1 hour, feed liquid weight ratio be 1：10, to filter, concentration is dried, and respectively obtains the extraction of pumpkin water
Thing D, pepo water extract E and diaphragma juglandis water extract F, it is standby；
(4) ultra high pressure extraction
Psoralea corylifolia is extracted using ultrahigh-pressure extraction method, it is that the ethanol of 60vt%, liquid are solid that extractions pressure is 100Mpa, extract
Weight ratio is 90：1, Fructus Psoraleae extract is obtained, filtration is evaporated, crushes, and obtains material G, standby；
(5) mix
By formula weigh 10g material As, 2.5g material B, 2.5g material C, 2.5g material D, 2.5g material E, 1.5g material F,
1.5g material G, 0.0351g zinc gluconates, are well mixed, granulation, obtain final product.
Experimental example 1
This experimental example passes through research pharmaceutical composition to normal rat and the Germicidal efficacy of frequent micturition rat model, to prove this
What invention was provided improves male sex's frequent micturition, the therapeutic action of the health-care food composition of the urinary incontinence.
1. materials and methods
1.1 animals
The Wistar rats of body weight 350-450g are chosen, is provided by Heilongjiang University of Chinese Medicine.
1.2 medicines and consumption
Composition according to obtained by comparative example 1-6 and embodiment 1-6, dose is 3g/kg.Comparison medicine：She Niting (wine
Stone acid tolterodine tablet), Meirui Pharmaceutical Co., Ltd, Nanjing, dose is 0.3mg/kg.
2. method
The impact that composition obtained by 2.1 comparative examples 1-6 and embodiment 1-6 is urinated to frequent micturition rat model
Normal male rats 120 are taken, stochastic averagina is divided into 15 groups：Sham-operation group, model group, control group (She Niting),
Comparative example 1-6 group, embodiment 1-6 group.Yellow Jackets intraperitoneal anesthesia, back fixation are used, bottom is lost hair or feathers, sterilization, uses scalpel
The osculum of 2cm length is cut along Ventral Midline, hypogastric nerve is searched, pushes descending colon and rectum to side, in mesenterium just now
Central authorities abut posterior abdominal wall, there is the as hypogastric nerve that the white fiber of 2 hair thicknesses is almost parallel with ureter, separate both sides
Hypogastric nerve, cuts off (sham-operation group only does cutting operation, does not cut off nerve), sews up a wound, normal to raise 2 weeks.It is right after 2 weeks
According to group, comparative example 1-6 group, embodiment 1-6 group according to dosage gastric infusion, sham-operation group and model group give the distillation of same dose
Water, was respectively charged into rat in rat metabolism cage after 1 hour by packet, observation each group the 1st urination time of rat, in 2 hours
Number of micturitions and the urine volume in 2 hours change, and experimental result is referring to table 1.
The impact that the composition of the comparative example 1-6 group of table 1 and embodiment 1-6 group is urinated to frequent micturition rat model
With sham-operation group ratio△P ＜ 0.05, with model group than * P ＜ 0.05, * * P ＜ 0.01.
Impact of the 2.2 embodiment 1-8 compositions to normal rat urine
Normal male rats 140 are taken, stochastic averagina is divided into 14 groups：Blank group, control group, comparative example 1-6 group, embodiment
1-6 groups.In addition to normal raising, the daily according to dosage gastric infusion of control group, comparative example 1-6 group, embodiment 1-6 group, blank group is given
Give the distilled water of same dose, successive administration 7 days.Before administration and it is administered and observes and record within the 1st, 3,7 days rat daytime
With evening urine volume, experimental result is referring to table 2.
Impact of the composition of the comparative example 1-6 group of table 2 and embodiment 1-6 group to normal rat urine
With blank group ratio△P ＜ 0.05,△△P ＜ 0.01, with control group than * P ＜ 0.05.
3. conclusion
The data result of table 1 shows that model group shortens compared with the 1st urination time of rat of sham-operation group, urination time in 2 hours
Number increases, and has obvious difference, illustrates modeling success.Rat is taking the group of comparative example 1-6 group and embodiment 1-6 group
After compound, its urine urgency-frequency degree and urine volume have reduction, there is notable difference compared with model group；Further look at and draw,
The urine urgency-frequency degree of embodiment 1-3 group and urine volume are less than comparative example 1-2 group, the urine urgency-frequency degree of embodiment 4-6 group and urine
Amount is less than comparative example 3-6 group, and the urine urgency-frequency degree and urine volume of 6 groups of embodiment are minimum, illustrates the formula each component of the present invention
Between it is mutually coordinated, positive effect is played jointly, achieve preferable therapeutic effect.Wherein：
The urine urgency-frequency degree and urine volume of 2 groups of comparative example be less than 1 group of comparative example, the urine urgency-frequency degree of 4 groups of comparative example and
Urine volume is less than 3 groups of comparative example, illustrates inhibitory action of the pumpkin with the combination of pepo than one-component to hyperplasia of prostate
It is higher；
The urine urgency-frequency degree and urine volume of 3 groups of embodiment is less than comparative example 1-2 group, the urine urgency-frequency journey of comparative example 5-6 group
Degree and urine volume are less than 4 groups of comparative example, illustrate that diaphragma juglandis or the addition of Psoralea corylifolia play a driving role to the drug effect of the present composition；
The urine urgency-frequency degree and urine volume of 6 groups of embodiment is less than comparative example 5-6 group, illustrates that diaphragma juglandis and Psoralea corylifolia collaboration are deposited
It is more higher than the drug effect in the presence of difference when being among composition of the invention.
The data result of table 2 shows, to rat urine volume after the 3rd day after normal rat medication and the 7th day compared with before administration
There were significant differences, further demonstrates the composition of the present invention and has certain therapeutic effect to urine urgency-frequency degree and urine volume.
The pharmaceutical composition of the present invention of experimental example 2 is to improving the pharmacodynamics test of effect of prostatic disorders
1. experiment material
Test sample：Composition according to obtained by comparative example 1-6 and embodiment 1-6, dose is 2g/kg.Modeling is injected
Agent：Testosterone propionate.Animal germline：Kunming mouse.Animal Sex and quantity：Male, totally 122.The weight of animals：18～
22g。
2. experimental technique
Male mice 122 is taken, by body weight 14 groups are randomly divided into, 8～10 per group, respectively blank group, model group, right
Ratio 1-6 group, embodiment 1-6 group.In addition to normal raising, remaining each group mouse is subcutaneous daily in addition to blank control group for each group mouse
1 testosterone propionate (5mg/kg) of injection；Comparative example 1-6 group and according to dosage gastric infusion 1 time respectively of embodiment 1-6 group after 1h,
Blank group and model group give the distilled water of same volume, continuous 30 days.After last dose 24h, mouse is put to death, extract prostate.
Calculate prostate index (PI)：Weight of prostate (mg)/Mouse Weight * 10.Experimental result is referring to table 3.
Impact of the composition of comparative example 1-6 of table 3 and embodiment 1-6 to mouse prostate weight and prostate index (PI)
Note：△△P ﹤ 0.01 are compared in expression with blank control group, and * * are represented and compared P ﹤ 0.01 with model group, and * is represented and model
Group compares P ﹤ 0.05.
3. conclusion
From table 3 it is observed that the composition of comparative example 1-6 and embodiment 1-6 can play suppression to hyperplasia of prostate
Effect.Further research shows that the prostate index of embodiment 1-3 group is less than comparative example 1-2 group, the prostatitis of embodiment 4-6 group
Gland index is less than comparative example 3-6 group, and the prostate index of 6 groups of embodiment is minimum, illustrates phase between the formula each component of the present invention
Mutually coordinate, positive effect is played jointly, achieve preferable therapeutic effect.Wherein：
The prostate index that 2 groups of comparative example is less than 1 group of comparative example, and the prostate index that 4 groups of comparative example is less than comparative example 3
Group, illustrates that pumpkin is more higher to the inhibitory action of hyperplasia of prostate than one-component with the combination of pepo；
The prostate index that 3 groups of embodiment is less than comparative example 1-2 group, and the prostate index of comparative example 5-6 group is less than contrast
4 groups of example, illustrates that diaphragma juglandis or the addition of Psoralea corylifolia play a driving role to the drug effect of the present composition；
The prostate index that 6 groups of embodiment is less than comparative example 5-6 group, illustrates that diaphragma juglandis and Psoralea corylifolia collaboration are present in this
It is more higher than the drug effect in the presence of difference when among bright composition.
The pharmaceutical composition of the present invention of experimental example 3 to male sex's frequent micturition, urgent urination, the urinary incontinence clinical research
Urine urgency-frequency is a kind of common disease, and with the increase at age, its incidence of disease gradually increases, and pathogenesis compared with
For complexity, effective treatment method is lacked at present.Urine urgency-frequency controlled micturition number of times is up to 20～30 times/d, and total volume of urine is without increasing
Plus.Patient has urgency but painless, drastically influence the daily life of patient.
1. clinical data and method
1.1 clinical datas and packet
In in March, 2016 to the man that selection 60 is with frequent micturition, urgent urination as illness between in September, 2016 and the course of disease was more than 1 month
Property patient, is randomly divided into 3 groups, per group of 20 people, respectively control group, 3 groups of embodiment, 6 groups of embodiment.
1.2 inclusive criterias
Sex is the male sex, and the age, night total urination time was averagely more than 3 times between 35-55 year.
1.3 diagnostic criteria
Tcm symptom is aversion to cold and cold limbs, frequent urination, the powerless deficiency of vital energy, soreness of waist and knee, pale tongue with white fur, excludes bladder and urethra
The urine urgency-frequency patient that organic disease patient and tumour, renal failure etc. cause.
1.4 treatment methods
Control group adopts regular western medicine treatment, according to dosage (5mg/ pieces, one time 2,3 times a day) oral Racanisodamine
Piece；According to dosage (25g/ time, a day three times) takes the composition of embodiment 3 to 3 groups of embodiment, 6 groups of embodiment according to dosage (25g/
Secondary, a day three times) take the composition of embodiment 6.
1.5 observation index
Work and rest at ordinary times by patient, solution to the greatest extent urine is gone to bed the following period of time got up only to morning next day of having fallen asleep, record urine
Number of times, continuously urine amount, record 7 days.Average.Before medication, medication 3 months and the course for the treatment of terminate after each observation 1 time.
1.6 effective evaluations
Symptom is wholly absent to cure, and symptom substantially mitigates as effective, symptom mitigation but not up to 50% for effective, disease
Shape does not mitigate even plus severe one is invalid.
2. result
The control group enuresis nocturna frequency index situation of change of table 4
Note：△P ＜ 0.05 compared with pre-treatment, the * P ＜ 0.05 compared with treatment 3 months.
5 embodiment of table, 3 groups of enuresis nocturna frequency index situations of change
| Before treatment | Treatment 3 months | Treatment 6 months | |
| Urine | 5.8±1.3 | 3.6±1.1△ | 2.2±0.9* |
| Nocturnal urine volume (ml) | 738.3±145.3 | 632.5±125.7△ | 440.1±121.4* |
Note：△P ＜ 0.05 compared with pre-treatment, the * P ＜ 0.05 compared with treatment 3 months.
6 embodiment of table, 6 groups of enuresis nocturna frequency index situations of change
| Before treatment | Treatment 3 months | Treatment 6 months | |
| Urine | 5.7±1.3 | 3.1±1.1△ | 2.0±0.9* |
| Nocturnal urine volume (ml) | 735.5±132.5 | 622.1±110.8△ | 432.1±115.2* |
Note：△P ＜ 0.05 compared with pre-treatment, the * P ＜ 0.05 compared with treatment 3 months.
The embodiment group of table 7 and control group Comparison of therapeutic
Note：* P ＜ 0.05 compared with control group.
As a result show, control group makes moderate progress with administration group enuresis nocturna frequency after medication, average enuresis nocturna number of times and nocturnal urine output
Significantly reduce, the health-care food composition for illustrating the present invention has some improvement to male sex's frequent micturition, urgent urination.
Claims (10)
1. a kind of health-care food composition for improving male sex's frequent micturition, the urinary incontinence, it is characterised in that by the raw material group of following weight portion
Part composition：5～20 parts of rape pollen, 2～5 parts of pumpkin, 2～5 parts of pepo, 0.5～3 part of Fructus Psoraleae extract；It is preferred that
, described health-care food composition is made up of the material component of following weight portion：10 parts of rape pollen, 2.5 parts of pumpkin, west
2.5 parts of cucurbit seed, 1.5 parts of Fructus Psoraleae extract.
2. the preparation method of health-care food composition described in claim 1, it is characterised in that comprise the following steps：
(1) sterilize
Rape pollen is carried out into sterilization treatment, then be dry, pulverize, sieved, obtain material A, it is standby；
(2) cure
Crush after pumpkin, pepo are cured, sieve, respectively obtain material B, C, it is standby；
(3) ultra high pressure extraction
Psoralea corylifolia is extracted using ultrahigh-pressure extraction method, Fructus Psoraleae extract is obtained, filtration is evaporated, crushes, and obtains material D, standby
With；
(4) mix
Weight portion as described in claim 1 weighs respectively tetra- kinds of materials of A, B, C, D, is well mixed, and obtains final product.
3. preparation method according to claim 3, it is characterised in that sterilization treatment described in step (1) is low temperature sterilization
Process；The drying is low temperature drying；It is described to sieve to cross 80～100 mesh sieves；Sieve described in step (2) to cross 80～100
Mesh sieve；Ultrahigh-pressure extraction method described in step (3) extract pressure be 100Mpa, extract be the ethanol of 60vt%, liquid weighs admittedly
Amount is than being 90：1.
4. a kind of health-care food composition for improving male sex's frequent micturition, the urinary incontinence, it is characterised in that by the raw material group of following weight portion
Part composition：5～20 parts of rape pollen, 0.4～5 part of pumpkin seed oil, 0.4～4 part of pumpkin water extract, pepo oil 0.4
～5 parts, 0.4～4 part of pepo water extract, 0.0175～0.0702 part of zinc gluconate, Fructus Psoraleae extract 0.5～3
Part, 0.5～3 part of diaphragma juglandis water extract；Preferably, described health-care food composition by following weight portion material component group
Into：10 parts of rape pollen, 2.5 parts of pumpkin seed oil, 2.5 parts of pumpkin water extract, 2.5 parts of pepo oil, pepo water
2.5 parts of extract, 0.0351 part of zinc gluconate, 1.5 parts of Fructus Psoraleae extract, 1.5 parts of diaphragma juglandis water extract.
5. the preparation method of health-care food composition described in claim 4, it is characterised in that comprise the following steps：
(1) sterilize
Rape pollen is carried out into sterilization treatment, then be dry, pulverize, sieved, obtain material A, it is standby；
(2) cold press is extracted
Pumpkin is peeled off, and takes seed benevolence, and pumpkin seed is extracted oil, and obtains pumpkin seed oil, i.e. material B, and the pumpkin seedcake after squeezing,
It is standby；
Pepo is peeled off, and takes seed benevolence, by the oil expression of pepo benevolence, obtains pepo oil, i.e. material C, and the west after squeezing
Cucurbit seedcake, it is standby；
(3) water extraction
Pumpkin seedcake after squeezing, cucurbita pepo seedcake and diaphragma juglandis are respectively adopted into water extraction method to be extracted, are filtered, concentration is done
It is dry, pumpkin water extract D, pepo water extract E and diaphragma juglandis water extract F are respectively obtained, it is standby；
(4) ultra high pressure extraction
Psoralea corylifolia is extracted using ultrahigh-pressure extraction method, Fructus Psoraleae extract is obtained, filtration is evaporated, crushes, and obtains material G, standby
With；
(5) mix
Seven kinds of materials of A-G and zinc gluconate are weighed according to the weight portion described in claim 4, is well mixed, pelletized, obtained final product.
6. preparation method according to claim 5, it is characterised in that sterilization treatment described in step (1) is low temperature sterilization
Process；The drying is low temperature drying；It is described to sieve to cross 80～100 mesh sieves.
7. preparation method according to claim 5, it is characterised in that by pumpkin seed oil expression to make described in step (2)
Carry out cold press with oil press, 70 DEG C of adjustment oil extruder bore temperature, pressure 3.5Mpa, rotating speed 36r/min, 3-4 time repeatedly；It is described
It is to carry out cold press, 80 DEG C of adjustment oil extruder bore temperature, pressure 3.6Mpa, rotating speed using oil press by the oil expression of pepo benevolence
36r/min, 3-4 time repeatedly.
8. preparation method according to claim 5, it is characterised in that the Extracting temperature that water described in step (3) is extracted is
100 DEG C, extraction time be 1 hour, feed liquid weight ratio be 1：10～1：20.
9. preparation method according to claim 5, it is characterised in that the extraction of ultrahigh-pressure extraction method described in step (4)
Pressure be 100Mpa, extract be the ethanol of 60vt%, solvent and solute weight ratio be 90：1.
10. the health-care food composition described in claim 1 or 4 is in preparation improves male sex's frequent micturition, urinary incontinence health food
Using.
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| CN109568470A (en) * | 2019-01-24 | 2019-04-05 | 哈尔滨快好药业有限公司 | Shenkangning capsules, which combine zinc gluconate oral administration solution, is improving the application in the symptoms such as kidney-yang deficiency person's frequent urination at night urinary incontinence urine urgency-frequency |
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Effective date of registration: 20171009 Address after: 150025 Zhuhai Road, Limin District, Hulan District, Heilongjiang, Harbin Applicant after: Harbin quick good Pharmaceutical Co., Ltd. Address before: 150025 middle section of Beijing Road, Limin economic and Technological Development Zone, Harbin City, Heilongjiang Applicant before: Loctite Harbin Pharmaceutical Co., Ltd. |
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Address after: 150025 Zhuhai Road, Limin District, Hulan District, Heilongjiang, Harbin Applicant after: Letai Pharmaceutical Co.,Ltd. Address before: 150025 Zhuhai Road, Limin District, Hulan District, Heilongjiang, Harbin Applicant before: HARBIN KUAIHAO PHARMACEUTICAL Co.,Ltd. |
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