CN104173905B - A kind of Chinese and Western medicine composite preparation for treating constipation and preparation method thereof - Google Patents
A kind of Chinese and Western medicine composite preparation for treating constipation and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of Chinese and Western medicine composite preparation for treating constipation and preparation method thereof, the preparation includes traditional Chinese medicine ingredients, western medicine composition and auxiliary material, and the traditional Chinese medicine ingredients are made up of following bulk drug：Camellia oleosa seeds, Chinese torreyanut, Perilla frutescens, radish seed, the seed of Oriental arborvitae, dessert almond, japanese plum seed, wild walnut meat, peach kernel, juglandis,semen, fructus cannabis, Snakegourd Seed, fructus amomi, fructus alpiniae oxyphyllae, the western medicine composition are functional oligose.The present invention be directed to deficient and weak YANG QI, raw in cold sensation of the genitalia, and sluggish stomach, yang-energy is not transported, body fluid not constipation due to endogenous cold caused by cloth, can warming kidney and enhancing yang, warm spleen warms up kidney, invigorates the kidney and stops nocturnal emission, treating stranguria promoting blood circulation, to reach the purpose to relax bowel；In addition, selected functional oligose can improve vitamin metabolism, bowel dysfunction is prevented, suppresses the growth of harmful intestinal tract bacteria and pathogenic bacteria, plays a part of improving intestinal environment and protects enteron aisle.Medicament of the present invention is effected a permanent cure by Integrated TCM, Chinese medicine, Western medicine conditioning, is given full play to curative effect, is controlled difficulty in relapse after healing.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, specifically a kind of Chinese and Western medicine composite preparation for treating constipation and its preparation side
Method.
Background technology
Constipation refers to that excrement is detained too long in enteric cavity, and large quantity of moisture is absorbed by intestinal wall, causes excrement dry, hard, is not easy
The phenomenon solved.Constipation is one of digestive system common disease, is mainly in the people of sedentary occupation, either activity very little or
Life is excessively nervous, and in recent years due to the change of dietary structure, the incidence of disease more and more higher of constipation, age of onset is also increasingly
It is low, it is increasingly becoming a big factor of puzzlement people's normal life.
The clinical classification of constipation, it is divided into acute constipation and chronic constipation according to the course of disease or mode of onset；It can be divided into by the cause of disease
Organic constipation and functional consitipation；The position accumulated by excrement block can be divided into colon type constipation and rectum type constipation.
Chinese medical discrimination thinks constipation more caused by insufficiency of the spleen, damage of kidney-YIN, the sinking of qi of middle-jiao and insufficiency of vital energy and blood, can be divided into as
Lower four kinds：Heat is secret, gas is secret, constipation due to endogenous cold, empty secret.
So-called heat is secret, refers to, because stomach and intestine accumulated heat, i.e. dryness-heat stagnating in the interior, consumption hinder body fluid, make large intestine conduction lose profit, dry and hard excrement
Caused by constipation.Heat is secret to be apt to occur in innate excess of YANG in the body, is addicted to drink, eating maror, or the people after pyreticosis.The secret generation of heat is more
Due to innate excess of YANG in the body or the pungent savoury of diet, or after pyreticosis, dryness-heat stagnating in the interior, consumption of body fluid by heat, FU QI being obstructed, and cause enteron aisle strongly fragrant
Heat, lose in making moist.It mainly sees that disease and dialectical main points are that internal fever is obvious, dry and hard excrement, belly turgor, by pain,
Dry halitosis, red tongue body, dry and yellowish fur, pulse condition is sliding and counts.In addition, some internal fevers simultaneous can also be seen, as scanty drak urine, dispute are given birth to
The diseases such as the hot flushing of sore, body.
So-called gas is secret to be referred to due to depression and stagnation of QI, is led to drop dereliction of duty, is made to stop in waste matter, can not descending caused constipation.Gas is secret
It is mainly in sorrow, worries beyond measure, the people that feelings will is not smooth or sitting is much moved.Gas is secret and heat secret belongs to real example constipation.
So-called constipation due to endogenous cold refers to due to deficient and weak YANG QI, raw in cold sensation of the genitalia, causes yang-energy obstructed, enteron aisle transmits powerless, involved and abstruse institute of defecating
The constipation of cause.Constipation due to endogenous cold is mainly in worn with age and patients on long-term.The Chinese medical discrimination main points of constipation due to endogenous cold are：Innate deficiency of YANG in the body, or yang-energy after being ill
Void is declined, so that yin-cold excess, stagnated stomach, and yang-energy is not transported, body fluid not cloth, so form the card of constipation due to endogenous cold.It mainly sees that disease is:Greatly
Just it is involved and abstruse, discharge is difficult, crymodynia in abdomen, four limbs are not warm, waist and knee is sour cold, tongue nature is light, tongue is thin, slow and sunken pulse, and involved and abstruse to defecate, row
Go out difficulty, crymodynia, four limbs are warm in abdomen, heavy pulse condition is its dialectical main points late.Its accompanying symptoms has a clear abundant urine, the complexion white light void such as in vain
It is cold as.Such as belong to cold real stagnation, then card is shown in constipation, turgor of suffering from abdominal pain, hot drink preference, and anemophobia is trembled with fear, and stringy and tense pulse effectively waits card.
The secret constipation i.e. caused by asthenic symptoms of so-called void, is due to overstrain, diet internal injury or postpartum, after being ill and aged debility,
Qi-blood deficiency, then large intestine transmission is powerless for the deficiency of vital energy, and then body fluid can not moisten large intestine to the deficiency of blood, and cause stool discharge difficult, so that secret
Tie obstructed.Void is secret to be divided into constipation due to deficiency of vital energy, blood deficiency and constipation and qi and blood all empty classes of constipation three.Empty secret Chinese medical discrimination will be：Patient
Because of overstrain, Nian Gaojin decline or after being ill, postpartum and excessive blood loss so that deficient qi and blood.The deficiency of vital energy then transmits powerless, and the deficiency of blood is then
Large intestine loses honor, therefore sees that constipation or defecation are difficult.Therefore for empty secret and when being divided into two aspects of constipation due to deficiency of vital energy and blood deficiency and constipation.
The dialectical main points and main symptom of constipation due to deficiency of vital energy are:Though patient has awareness of defecation, often earn weak in facing lavatory and exert, earn then sweating shortness of breath, tongue
Matter it is light it is tender, tongue is thin, feeble pulse, and have that complexion white light is white, god tired fright due to decicincy of qi, the after an action of the bowels syndrome of qi deficiency such as weak concurrently.Sometimes it there is also anus
Pendant is compeled, and very then the collapse from qi deficiency such as prolapse of the anus is demonstrate,proved.The dialectical main points and main symptom of blood deficiency and constipation are patient's constipation such as chestnut, because of the deficiency of blood
See the diseases such as simple and unadorned sallow complexion, lip pawl pale tongue, arteries and veins be thin, and have concurrently and have a dizzy spell, the syndrome of blood deficiency such as palpitaition.The deficiency of blood has the deficiency of Yin concurrently simultaneously
Person, be also shown the yin asthenia generating intrinsic heat such as the few Tianjin of dry, dysphoria in chestpalms-soles as.
It is various that the medicament categories of constipation are treated on medical market, it is most of all oneself when constipation occur in many constipation patients
Row goes to pharmacy to buy medicine, hardly realizes, the treatment of constipation should also suit the remedy to the case according to different constipation types.But at present, also
The medicine do not treated specifically for certain type of constipation.
The content of the invention
According to the problem of set forth above, the present invention provides a kind of Chinese and Western medicine composite preparation for treating constipation, and the medicament is special
Constipation due to endogenous cold is treated, it is evident in efficacy, it is uneasy to recur.
Second object of the present invention is to provide a kind of preparation method for the Chinese and Western medicine composite preparation for treating constipation.
The technical scheme is that：A kind of Chinese and Western medicine composite preparation for treating constipation, by weight including Chinese medicine into
Point 40-60 parts, western medicine composition 5-8 parts, auxiliary material 15-25 parts, wherein, the traditional Chinese medicine ingredients by following parts by weight bulk drug group
Into：12-20 parts camellia oleosa seeds, 30-80 parts Chinese torreyanut, 6-10 parts Perilla frutescens, 8-16 parts radish seed, 20-30 parts seed of Oriental arborvitae, 20-40 parts
Dessert almond, 6-18 parts japanese plum seed, 20-60 parts wild walnut meat, 18-56 parts peach kernel, 20-50 parts juglandis,semen, 2-8 parts fructus cannabis, 16-
40 parts of Snakegourd Seeds, 4-12 parts fructus amomi, 7-15 part fructus alpiniae oxyphyllaes, the western medicine composition are functional oligose.
Further, the preparation method of described traditional Chinese medicine ingredients is：
(1) Chinese torreyanut, radish seed, Snakegourd Seed, fructus amomi, fructus alpiniae oxyphyllae are weighed respectively by the proportioning, be respectively placed in pot, with text
It is fiery to fry slowly to ripe, taking-up, cooling；
(2) camellia oleosa seeds, Perilla frutescens, the seed of Oriental arborvitae, dessert almond, japanese plum seed, wild walnut meat, peach kernel, Hu are weighed by the proportioning
Peach kernel, fructus cannabis, mixed with above-mentioned by the Chinese torreyanut of frying, radish seed, Snakegourd Seed, fructus amomi, fructus alpiniae oxyphyllae, shell, shell as not
Shelling completely, ensure shell-containing rate 28% or so, shell-containing rate too it is low be not easy it is fuel-displaced, squeezed with ZX10 screw oil expellers it is fuel-displaced,
Obtain oil and press cake slag is standby；
(3) alcohol reflux that above-mentioned press cake slag is 60-80% with concentration is extracted twice, each 0.5-1.5 hours, closed
And extract solution, filtering, filtrate recycling ethanol, thick paste is concentrated under reduced pressure into, extract powder is made in spray drying, standby；
(4) extract powder that step (3) prepares is added in the oil of step (2) preparation, emulsifying agent is added, by glue
Body is ground, and produces traditional Chinese medicine ingredients.
Further, the functional oligose be FOS, xylo-oligosaccharide, galactooligosaccharide, oligoisomaltose,
Any one in soyabean oligosaccharides or more than one mixtures.
Further, its component of the auxiliary material and parts by weight are respectively：1-3 parts polyglycerol ester, 0.4-0.7 part para hydroxybenzenes
Methyl formate, 0.3-0.5 part sorbierites.Wherein, polyglycerol ester also serves as surfactant, can made insoluble as wetting agent
Evenly spread in the western medicine composition of grease in traditional Chinese medicine ingredients, methyl p-hydroxybenzoate plays antisepsis, mountain as preservative
Pears alcohol serves moulding as plasticizer.
A kind of preparation method for the Chinese and Western medicine composite preparation for treating constipation, comprises the following steps：
(1) Chinese torreyanut, radish seed, Snakegourd Seed, fructus amomi, fructus alpiniae oxyphyllae are weighed respectively by the proportioning, be respectively placed in pot, with text
It is fiery to fry slowly to ripe, taking-up, cooling；
(2) camellia oleosa seeds, Perilla frutescens, the seed of Oriental arborvitae, dessert almond, japanese plum seed, wild walnut meat, peach kernel, Hu are weighed by the proportioning
Peach kernel, fructus cannabis, mixed with above-mentioned by the Chinese torreyanut of frying, radish seed, Snakegourd Seed, fructus amomi, fructus alpiniae oxyphyllae, shell, shell as not
Shelling completely, ensure shell-containing rate 28% or so, shell-containing rate too it is low be not easy it is fuel-displaced, squeezed with ZX10 screw oil expellers it is fuel-displaced,
Obtain oil and press cake slag is standby；
(3) alcohol reflux that above-mentioned press cake slag is 60-80% with concentration is extracted twice, each 0.5-1.5 hours, closed
And extract solution, filtering, filtrate recycling ethanol, thick paste is concentrated under reduced pressure into, extract powder is made in spray drying, standby；
(4) extract powder that step (3) prepares is added in the oil of step (2) preparation, emulsifying agent is added, by glue
Body is ground, and produces traditional Chinese medicine ingredients；
(5) after polyglycerol ester mixing being added in above-mentioned traditional Chinese medicine ingredients, western medicine composition, P-hydroxybenzoic acid are sequentially added
Methyl esters, sorbierite, are made soft capsule, produce.
The pharmacology of medicinal material selected by traditional Chinese medicine ingredients is as follows：
Camellia oleosa seeds：Promoting the circulation of qi；Ease constipation；Desinsection.Main qi-stagnating abdominalgia；Dry constipation of intestines；Roundworm；Hookworm；Mange itch.
Chinese torreyanut：Killing insect and eliminating accumulation, moistening dryness for relaxing bowels.For hookworm, roundworm, taeniasis, abdominal pain due to enterositosis, infantile malnutrition, big constipation
Knot.
Perilla frutescens：Acrid flavour；It is warm-natured.Ease constipation；Black hair.Main dry constipation of intestines；Hair is uninteresting.
Radish seed：Fatty oil, volatile oil.There is methyl mercaptan in volatile oil.Deng.Erucic acid containing volume in fat oil., sub- oil
Acid, leukotrienes, glycerol sinapate.
Peach kernel：Bitter sweet, put down.The blood-breaking row stasis of blood, moisturize laxation.Controlling through closing, abdominal mass, pyreticosis store blood, wandering arthritis, malaria, bruise damage
Wound, blood stasis and swelling pain, the dry constipation of blood.
Fructus cannabis：It is sweet, put down.Moisturize, laxation is treating stranguria, promoting blood circulation.Dry constipation of intestines is controlled, is quenched one's thirst, heat gonorrhea, wandering arthritis, dysentery.Menstruation
It is uncomfortable, scabies, tinea leprosy.
The seed of Oriental arborvitae：It is sweet；It is mild-natured.Mental-tranquilization；Arrest sweating；Relax bowel.Main palpitation with fear palpitation；It is forgetful for dysphoria insomnia；It is cloudy
Empty night sweat, dry constipation of intestines.
Dessert almond：It is sweet, it is mild-natured.Moistening lung, relieving asthma.Control consumptive disease cough and asthma, dry constipation of intestines.《Modern Practical Chinese medicinal》：" have moist
Property, take tool laxative effective orally, and have the effect of nourishing.External application is usually used in making dressing during exfoliation, in protective effect.《In Sichuan
Medicine will》：" the energy wide stomach of moistening lung, expelling phlegm and arresting coughing.Control cough due to consumptive disease asthma, trusted subordinate against vexed, especially with control dryness, void cough most
Preferably."
Japanese plum seed：It is bitter；It is flat；It is nontoxic.Dissolving stasis, Li Shui, ease constipation.Main blood stasis pain, traumatic injury, oedema expansion, tinea pedis, intestines
Dry constipation.
Wild walnut meat：It is warm-natured flat, it is sweet.Moistening lung for removing phlegm；Warming kidney and enhancing yang；Moisturizing；Defaecation.Main cough caused by dryness is without phlegm；Void asthma；Waist and knee
It is aching and limp；Dry constipation of intestines；Chapped skin.
Juglandis,semen：It is sweet, temperature.Invigorate the kidney and stop nocturnal emission, warm lung Dingchuan, ease constipation, control kidney deficiency asthma and cough, pain in the back flaccidity of lower limbs, impotence, pass out semen, it is small
Just frequency, urolithiasis, dry feces.
The seed of Oriental arborvitae：It is sweet；It is pungent；It is mild-natured.Mental-tranquilization；Relax bowel.Main palpitation and insomnia；Hidrosis is passed out semen；Dry constipation of intestines.
Snakegourd Seed：Sweet, slight bitter, tremble with fear.Return lung, stomach, large intestine channel.Effect：Clearing heat and eliminating phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens, relax bowel.Snakegourd Fruit
Seed contains unrighted acid 16.8%, protein 5.46%, and contains 17 kinds of amino acid, three patch saponins, multivitamin and calcium,
16 kinds of trace elements such as iron, zinc, selenium.
Fructus amomi：Easing stomach-QI, eliminate dyspepsia, reason stomachache, fast diaphragm, adjust spleen.
Fructus alpiniae oxyphyllae：It is pungent, temperature.Warm spleen, warm up kidney, solid and gas, puckery essence.Cold air stomachache is controlled, syncope due to pathogenic cold is vomited and diarrhoea, more salivas, seminal emission, more than urine
Drip, many nights many urine.Frying takes net fructus alpiniae oxyphyllae to put in pot, and it is in burnt brown to fry with high heat to shell, is heaved, and kernel is degree in yellow,
Take out, grind shell.
The pharmacology of western medicine composition is as follows：To large intestine by Bifidobacterium and some lactic acid bacterias after functional oligose intake human body
Utilize, be that the beneficial bacterium in enteron aisle absorbs decomposition, and suppress the propagation of external source pathogenic bacteria and the intrinsic putrefactivebacteria of enteral, reduction has
The generation of malicious tunning and harmful bacteria.And the spoilage organisms such as the Bacillus perfringens of harmful intestinal tract and clostridium can not utilize,
This is due to the acceptor that bifidobacterium cells surface has oligosaccharides, and many oligosaccharides are effective bifidus factors.Bifidobacterium is
A kind of unique endotoxin that neither produces does not produce exotoxin again in human intestine's flora, and no pathogenicity has many physiology work(
The beneficial microbe of energy.There are many health-care effects to human body, such as improve vitamin metabolism, prevent bowel dysfunction, suppress enteron aisle
Middle harmful bacteria and the growth of pathogenic bacteria, beneficial bacterium bacterium is helped to be cooperated by phosphatidic acid and Intestinal epithelial cells, it is and other
Anaerobic bacteria occupies intestinal mucosa surface jointly, forms one layer of membranes barriers with protective effect, prevents the invasion of pernicious bacteria,
Treated constipation so as to reach anti-, suppress the propagation of harmful intestinal tract flora, improve intestinal environment and protection enteron aisle, anti-aging, anti-cancer and
Liver-protective effect.Intestines peristalsis can be stimulated because bifidobacterium fermentation oligosaccharide produces substantial amounts of short chain fatty acids, is increased
The wettability of excrement, and by the raised growth of thalline to keep certain osmotic pressure, so as to prevent the generation of constipation.In addition it is low
Glycan belongs to water-soluble dietary fiber, can promote small bowel peristalsis, also can prevent and mitigate constipation.In addition to above-mentioned function, experiment hair
Also prevention and treatment lactose digestion is bad for existing some functional oligoses, improves the effect that enteron aisle absorbs to mineral element.
Beneficial effects of the present invention are：It is disclosed by the invention it is a kind of treat constipation Chinese and Western medicine composite preparation it is selected it is a variety of in
Medicinal material, raw in cold sensation of the genitalia for deficient and weak YANG QI, stagnated stomach, and yang-energy is not transported, body fluid not constipation due to endogenous cold caused by cloth, can warming kidney and enhancing yang,
Warm spleen warms up kidney, invigorates the kidney and stops nocturnal emission, treating stranguria promoting blood circulation, to reach the purpose to relax bowel；In addition, the functional oligose selected by the present invention
Intestines peristalsis can be stimulated by producing substantial amounts of short chain fatty acids, increase the wettability of excrement, and by the raised growth of thalline to protect
Certain osmotic pressure is held, so as to prevent the generation of constipation, vitamin metabolism can also be improved, prevents bowel dysfunction, suppresses intestines
The growth of harmful bacteria and pathogenic bacteria in road, playing improves intestinal environment and protection enteron aisle, anti-aging, anti-cancer and liver-protective work
With.Medicament of the present invention is effected a permanent cure by Integrated TCM, Chinese medicine, Western medicine conditioning, is given full play to curative effect, will not be recurred after healing.
Embodiment
Embodiment 1：
A kind of Chinese and Western medicine composite preparation for treating constipation, by weight including 40 parts of traditional Chinese medicine ingredients, 5 parts of western medicine composition,
15 parts of auxiliary material, wherein, the traditional Chinese medicine ingredients are made up of the bulk drug of following parts by weight：12 parts of camellia oleosa seedses, 30 portions of Chinese torreyanuts, 6 parts it is white
Perillaseed, 8 parts of radish seeds, 20 parts of seed of Oriental arborvitaes, 20 parts of dessert almonds, 6 parts of japanese plum seeds, 20 parts of wild walnut meats, 18 parts of peach kernels, 20 portions of English walnuts
Benevolence, 2 parts of fructus cannabis, 16 parts of Snakegourd Seeds, 4 parts of fructus amomis, 7 parts of fructus alpiniae oxyphyllaes, the western medicine composition are functional oligose.
Wherein, the functional oligose is FOS, xylo-oligosaccharide, galactooligosaccharide, oligoisomaltose, soybean
Any one in oligosaccharide or more than one mixtures.
Wherein, its component of the auxiliary material and parts by weight are respectively：1 part of polyglycerol ester, 0.4 part of methyl p-hydroxybenzoate,
0.3 part of sorbierite.Wherein, polyglycerol ester also serves as surfactant as wetting agent, can make Western medicine insoluble in grease into
Part is evenly spread in traditional Chinese medicine ingredients, and methyl p-hydroxybenzoate plays antisepsis as preservative, and sorbierite is as plasticizer
Serve moulding.
A kind of Chinese and Western medicine composite preparation for treating constipation, its preparation method are：
(1) Chinese torreyanut, radish seed, Snakegourd Seed, fructus amomi, fructus alpiniae oxyphyllae are weighed respectively by the proportioning, be respectively placed in pot, with text
It is fiery to fry slowly to ripe, taking-up, cooling；
(2) camellia oleosa seeds, Perilla frutescens, the seed of Oriental arborvitae, dessert almond, japanese plum seed, wild walnut meat, peach kernel, Hu are weighed by the proportioning
Peach kernel, fructus cannabis, mixed with above-mentioned by the Chinese torreyanut of frying, radish seed, Snakegourd Seed, fructus amomi, fructus alpiniae oxyphyllae, shell, shell as not
Shelling completely, ensure shell-containing rate 28% or so, shell-containing rate too it is low be not easy it is fuel-displaced, squeezed with ZX10 screw oil expellers it is fuel-displaced,
Obtain oil and press cake slag is standby；
(3) alcohol reflux that above-mentioned press cake slag concentration is 60% is extracted twice, 0.5 hour every time, merges extraction
Liquid, filtering, filtrate recycling ethanol, thick paste is concentrated under reduced pressure into, extract powder is made in spray drying, standby；
(4) extract powder that step (3) prepares is added in the oil of step (2) preparation, adds emulsifying agent, from following
Annular tube type colloid mill, by colloidal grinding, produce traditional Chinese medicine ingredients；
(5) after polyglycerol ester mixing being added in above-mentioned traditional Chinese medicine ingredients, western medicine composition, P-hydroxybenzoic acid are sequentially added
Methyl esters, sorbierite, are made soft capsule, produce.
Embodiment 2：
A kind of Chinese and Western medicine composite preparation for treating constipation, by weight including 50 parts of traditional Chinese medicine ingredients, western medicine composition 6.5
Part, 20 parts of auxiliary material, wherein, the traditional Chinese medicine ingredients are made up of the bulk drug of following parts by weight：16 parts of camellia oleosa seedses, 55 portions of Chinese torreyanuts, 8 parts
Perilla frutescens, 12 parts of radish seeds, 25 parts of seed of Oriental arborvitaes, 30 parts of dessert almonds, 12 parts of japanese plum seeds, 40 parts of wild walnut meats, 37 parts of peach kernels, 35 parts
Juglandis,semen, 5 parts of fructus cannabis, 28 parts of Snakegourd Seeds, 8 parts of fructus amomis, 11 parts of fructus alpiniae oxyphyllaes, the western medicine composition are functional oligose.
Wherein, the functional oligose is FOS, xylo-oligosaccharide, galactooligosaccharide, oligoisomaltose, soybean
Any one in oligosaccharide or more than one mixtures.
Wherein, its component of the auxiliary material and parts by weight are respectively：2 parts of polyglycerol esters, 0.55 part of methyl p-hydroxybenzoate,
0.4 part of sorbierite.Wherein, polyglycerol ester also serves as surfactant as wetting agent, can make Western medicine insoluble in grease into
Part is evenly spread in traditional Chinese medicine ingredients, and methyl p-hydroxybenzoate plays antisepsis as preservative, and sorbierite is as plasticizer
Serve moulding.
A kind of Chinese and Western medicine composite preparation for treating constipation, its preparation method are：
(1) Chinese torreyanut, radish seed, Snakegourd Seed, fructus amomi, fructus alpiniae oxyphyllae are weighed respectively by the proportioning, be respectively placed in pot, with text
It is fiery to fry slowly to ripe, taking-up, cooling；
(2) camellia oleosa seeds, Perilla frutescens, the seed of Oriental arborvitae, dessert almond, japanese plum seed, wild walnut meat, peach kernel, Hu are weighed by the proportioning
Peach kernel, fructus cannabis, mixed with above-mentioned by the Chinese torreyanut of frying, radish seed, Snakegourd Seed, fructus amomi, fructus alpiniae oxyphyllae, shell, shell as not
Shelling completely, ensure shell-containing rate 28% or so, shell-containing rate too it is low be not easy it is fuel-displaced, squeezed with ZX10 screw oil expellers it is fuel-displaced,
Obtain oil and press cake slag is standby；
(3) alcohol reflux that above-mentioned press cake slag concentration is 70% is extracted twice, 1.0 hours every time, merges extraction
Liquid, filtering, filtrate recycling ethanol, thick paste is concentrated under reduced pressure into, extract powder is made in spray drying, standby；
(4) extract powder that step (3) prepares is added in the oil of step (2) preparation, adds emulsifying agent, from following
Annular tube type colloid mill, by colloidal grinding, produce traditional Chinese medicine ingredients；
(5) after polyglycerol ester mixing being added in above-mentioned traditional Chinese medicine ingredients, western medicine composition, P-hydroxybenzoic acid are sequentially added
Methyl esters, sorbierite, are made soft capsule, produce.
Embodiment 3：
A kind of Chinese and Western medicine composite preparation for treating constipation, by weight including 60 parts of traditional Chinese medicine ingredients, 8 parts of western medicine composition,
25 parts of auxiliary material, wherein, the traditional Chinese medicine ingredients are made up of the bulk drug of following parts by weight：20 parts of camellia oleosa seedses, 80 portions of Chinese torreyanuts, 10 parts it is white
Perillaseed, 16 parts of radish seeds, 30 parts of seed of Oriental arborvitaes, 40 parts of dessert almonds, 18 parts of japanese plum seeds, 60 parts of wild walnut meats, 56 parts of peach kernels, 50 parts of Hus
Peach kernel, 8 parts of fructus cannabis, 40 parts of Snakegourd Seeds, 12 parts of fructus amomis, 15 parts of fructus alpiniae oxyphyllaes, the western medicine composition are functional oligose.
Wherein, the functional oligose is FOS, xylo-oligosaccharide, galactooligosaccharide, oligoisomaltose, soybean
Any one in oligosaccharide or more than one mixtures.
Wherein, its component of the auxiliary material and parts by weight are respectively：3 parts of polyglycerol esters, 0.7 part of methyl p-hydroxybenzoate,
0.5 part of sorbierite.Wherein, polyglycerol ester also serves as surfactant as wetting agent, can make Western medicine insoluble in grease into
Part is evenly spread in traditional Chinese medicine ingredients, and methyl p-hydroxybenzoate plays antisepsis as preservative, and sorbierite is as plasticizer
Serve moulding.
A kind of Chinese and Western medicine composite preparation for treating constipation, its preparation method are：
(1) Chinese torreyanut, radish seed, Snakegourd Seed, fructus amomi, fructus alpiniae oxyphyllae are weighed respectively by the proportioning, be respectively placed in pot, with text
It is fiery to fry slowly to ripe, taking-up, cooling；
(2) camellia oleosa seeds, Perilla frutescens, the seed of Oriental arborvitae, dessert almond, japanese plum seed, wild walnut meat, peach kernel, Hu are weighed by the proportioning
Peach kernel, fructus cannabis, mixed with above-mentioned by the Chinese torreyanut of frying, radish seed, Snakegourd Seed, fructus amomi, fructus alpiniae oxyphyllae, shell, shell as not
Shelling completely, ensure shell-containing rate 28% or so, shell-containing rate too it is low be not easy it is fuel-displaced, squeezed with ZX10 screw oil expellers it is fuel-displaced,
Obtain oil and press cake slag is standby；
(3) alcohol reflux that above-mentioned press cake slag concentration is 80% is extracted twice, 1.5 hours every time, merges extraction
Liquid, filtering, filtrate recycling ethanol, thick paste is concentrated under reduced pressure into, extract powder is made in spray drying, standby；
(4) extract powder that step (3) prepares is added in the oil of step (2) preparation, adds emulsifying agent, from following
Annular tube type colloid mill, by colloidal grinding, produce traditional Chinese medicine ingredients；
(5) after polyglycerol ester mixing being added in above-mentioned traditional Chinese medicine ingredients, western medicine composition, P-hydroxybenzoic acid are sequentially added
Methyl esters, sorbierite, are made soft capsule, produce.
Typical case：
Case one：Certain is defended, female, 59 years old.With suffering from abdominal pain 3 days, left lower abdomen pain is more obvious, pale complexion, language within 7 days for constipation
Sound is slightly weak, and four limbs are not warm, and happiness heat is cold, and sleep is poor, and tongue nature is light, and tongue is greasy in vain, and to be more in tongue, belly has no bulge, 2013 years 6
The moon 14 is medical.The Chinese and Western medicine composite preparation of present invention treatment constipation is taken after 1 day, stool releases, remission, no stomachache,
Sleep is taken a turn for the better, and after 3 days, defecation is obviously improved, and in 48h, just close to normally, stomachache disappears matter infrequent defecation, continues to take half
After individual month, cure, constipation disappears, and follow-up does not occur constipation in 1 year.
Case two：Lee, female, 25 years old, patient had constipation medical history 4 years, nearly three months exacerbation of symptoms, under dry and hard excrement difficulty,
Sometimes 1 week 1 row, continuous and dull pain in the abdomen, like temperature and be afraid of cold, shortness of breath uncomfortable in chest, weak, limbs burnout of having palpitation receives difference, and tongue nature is light, and tongue is greasy in vain, arteries and veins
It is heavy to moisten.First visit on May 13 in 2013, is diagnosed as constipation.The Chinese and Western medicine composite preparation of present invention treatment constipation is taken after 2 days, greatly
Just release, being defecated after 3 days, qualitative change is soft, and defecation is unobstructed earlier above, and stomachache and other all diseases substantially mitigate.After continuing medication 1 month,
Defecation is normal, and stomachache and other all diseases disappear, and follow-up does not occur constipation in 1 year.
Case three：Liu, man, 38 years old, with constipation more than 2 years, each defecation time length, difficult defecation, the frequent band of stomach
There is slightly distending pain, tongue nature is light, and tongue is white thin greasy, first visit on April 26 in 2013, is diagnosed as constipation.Take in present invention treatment constipation
After Western medicine compound formulation 2 days, the infrequent defecation time shortens 1d, and just matter is dry and hard, and stomachache, abdominal distension symptom improve；After taking 5, just
Secret to be obviously improved, infrequent defecation is in 48h, and just matter disappears close to normally, abdominal distension, stomachache are most of；After one month, constipation disappears
Lose, just matter is normal daily 1~2 time, and abdominal distension, colic symptoms disappear, and have cured, follow-up does not occur constipation in 1 year.
Finally it should be noted that：The above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations；Although
The present invention is described in detail with reference to the foregoing embodiments, it will be understood by those within the art that：It still may be used
To be modified to the technical scheme described in previous embodiment, or equivalent substitution is carried out to which part technical characteristic；And
These modifications are replaced, and the essence of appropriate technical solution is departed from the spirit and model of technical scheme of the embodiment of the present invention
Enclose.
Claims (3)
1. a kind of Chinese and Western medicine composite preparation for treating constipation, by weight including 40 parts of traditional Chinese medicine ingredients, 5 parts of western medicine composition, auxiliary
15 parts of material, wherein, the traditional Chinese medicine ingredients are made up of the bulk drug of following parts by weight：12 parts of camellia oleosa seedses, 30 portions of Chinese torreyanuts, 6 parts of common perillas
Son, 8 parts of radish seeds, 20 parts of seed of Oriental arborvitaes, 20 parts of dessert almonds, 6 parts of japanese plum seeds, 20 parts of wild walnut meats, 18 parts of peach kernels, 20 portions of English walnuts
Benevolence, 2 parts of fructus cannabis, 16 parts of Snakegourd Seeds, 4 parts of fructus amomis, 7 parts of fructus alpiniae oxyphyllaes, the western medicine composition are functional oligose；
The functional oligose is in FOS, xylo-oligosaccharide, galactooligosaccharide, oligoisomaltose, soyabean oligosaccharides
Any one or more than one mixtures；
Its component of the auxiliary material and parts by weight are respectively：1 part of polyglycerol ester, 0.4 part of methyl p-hydroxybenzoate, 0.3 portion of sorb
Alcohol；Wherein, polyglycerol ester also serves as surfactant, the western medicine composition insoluble in grease can be made uniformly to divide as wetting agent
It is scattered in traditional Chinese medicine ingredients, methyl p-hydroxybenzoate plays antisepsis as preservative, and sorbierite plays moulding work as plasticizer
With；
The preparation method of the Chinese and Western medicine composite preparation of described treatment constipation comprises the following steps：
(1) Chinese torreyanut, radish seed, Snakegourd Seed, fructus amomi, fructus alpiniae oxyphyllae are weighed respectively by the proportioning, be respectively placed in pot, it is slow with slow fire
Fry to ripe, taking-up, cooling；
(2) by it is described proportioning weigh camellia oleosa seeds, Perilla frutescens, the seed of Oriental arborvitae, dessert almond, japanese plum seed, wild walnut meat, peach kernel, juglandis,semen,
Fructus cannabis, mix, shell by the Chinese torreyanut of frying, radish seed, Snakegourd Seed, fructus amomi, fructus alpiniae oxyphyllae with above-mentioned, shell to be not exclusively de-
Shell, ensure shell-containing rate 28% or so, shell-containing rate is too low to be not easy fuel-displaced, is squeezed with ZX10 screw oil expellers fuel-displaced, obtains oil
It is standby with press cake slag；
(3) alcohol reflux that above-mentioned press cake slag concentration is 60% is extracted twice, 0.5 hour every time, merges extract solution, mistake
Filter, filtrate recycling ethanol, thick paste is concentrated under reduced pressure into, extract powder is made in spray drying, standby；
(4) extract powder that step (3) prepares is added in the oil of step (2) preparation, emulsifying agent is added, from circulation pipe
Formula colloid mill, by colloidal grinding, produce traditional Chinese medicine ingredients；
(5) after polyglycerol ester mixing being added in above-mentioned traditional Chinese medicine ingredients, western medicine composition, P-hydroxybenzoic acid first are sequentially added
Ester, sorbierite, are made soft capsule, produce.
2. a kind of Chinese and Western medicine composite preparation for treating constipation, by weight including 50 parts of traditional Chinese medicine ingredients, 6.5 parts of western medicine composition,
20 parts of auxiliary material, wherein, the traditional Chinese medicine ingredients are made up of the bulk drug of following parts by weight：16 parts of camellia oleosa seedses, 55 portions of Chinese torreyanuts, 8 parts it is white
Perillaseed, 12 parts of radish seeds, 25 parts of seed of Oriental arborvitaes, 30 parts of dessert almonds, 12 parts of japanese plum seeds, 40 parts of wild walnut meats, 37 parts of peach kernels, 35 parts of Hus
Peach kernel, 5 parts of fructus cannabis, 28 parts of Snakegourd Seeds, 8 parts of fructus amomis, 11 parts of fructus alpiniae oxyphyllaes, the western medicine composition are functional oligose；
The functional oligose is in FOS, xylo-oligosaccharide, galactooligosaccharide, oligoisomaltose, soyabean oligosaccharides
Any one or more than one mixtures；
Its component of the auxiliary material and parts by weight are respectively：2 parts of polyglycerol esters, 0.55 part of methyl p-hydroxybenzoate, 0.4 portion of sorb
Alcohol；Wherein, polyglycerol ester also serves as surfactant, the western medicine composition insoluble in grease can be made uniformly to divide as wetting agent
It is scattered in traditional Chinese medicine ingredients, methyl p-hydroxybenzoate plays antisepsis as preservative, and sorbierite plays moulding work as plasticizer
With；
A kind of preparation method of described Chinese and Western medicine composite preparation for treating constipation comprises the following steps：
(1) Chinese torreyanut, radish seed, Snakegourd Seed, fructus amomi, fructus alpiniae oxyphyllae are weighed respectively by the proportioning, be respectively placed in pot, it is slow with slow fire
Fry to ripe, taking-up, cooling；
(2) by it is described proportioning weigh camellia oleosa seeds, Perilla frutescens, the seed of Oriental arborvitae, dessert almond, japanese plum seed, wild walnut meat, peach kernel, juglandis,semen,
Fructus cannabis, mix, shell by the Chinese torreyanut of frying, radish seed, Snakegourd Seed, fructus amomi, fructus alpiniae oxyphyllae with above-mentioned, shell to be not exclusively de-
Shell, ensure shell-containing rate 28% or so, shell-containing rate is too low to be not easy fuel-displaced, is squeezed with ZX10 screw oil expellers fuel-displaced, obtains oil
It is standby with press cake slag；
(3) alcohol reflux that above-mentioned press cake slag concentration is 70% is extracted twice, 1.0 hours every time, merges extract solution, mistake
Filter, filtrate recycling ethanol, thick paste is concentrated under reduced pressure into, extract powder is made in spray drying, standby；
(4) extract powder that step (3) prepares is added in the oil of step (2) preparation, emulsifying agent is added, from circulation pipe
Formula colloid mill, by colloidal grinding, produce traditional Chinese medicine ingredients；
(5) after polyglycerol ester mixing being added in above-mentioned traditional Chinese medicine ingredients, western medicine composition, P-hydroxybenzoic acid first are sequentially added
Ester, sorbierite, are made soft capsule, produce.
3. a kind of Chinese and Western medicine composite preparation for treating constipation, by weight including 60 parts of traditional Chinese medicine ingredients, 8 parts of western medicine composition, auxiliary
25 parts of material, wherein, the traditional Chinese medicine ingredients are made up of the bulk drug of following parts by weight：20 parts of camellia oleosa seedses, 80 portions of Chinese torreyanuts, 10 parts of common perillas
Son, 16 parts of radish seeds, 30 parts of seed of Oriental arborvitaes, 40 parts of dessert almonds, 18 parts of japanese plum seeds, 60 parts of wild walnut meats, 56 parts of peach kernels, 50 portions of English walnuts
Benevolence, 8 parts of fructus cannabis, 40 parts of Snakegourd Seeds, 12 parts of fructus amomis, 15 parts of fructus alpiniae oxyphyllaes, the western medicine composition are functional oligose；
The functional oligose is in FOS, xylo-oligosaccharide, galactooligosaccharide, oligoisomaltose, soyabean oligosaccharides
Any one or more than one mixtures；
Its component of the auxiliary material and parts by weight are respectively：3 parts of polyglycerol esters, 0.7 part of methyl p-hydroxybenzoate, 0.5 portion of sorb
Alcohol；Wherein, polyglycerol ester also serves as surfactant, the western medicine composition insoluble in grease can be made uniformly to divide as wetting agent
It is scattered in traditional Chinese medicine ingredients, methyl p-hydroxybenzoate plays antisepsis as preservative, and sorbierite plays moulding work as plasticizer
With；
A kind of preparation method of described Chinese and Western medicine composite preparation for treating constipation comprises the following steps：
(1) Chinese torreyanut, radish seed, Snakegourd Seed, fructus amomi, fructus alpiniae oxyphyllae are weighed respectively by the proportioning, be respectively placed in pot, it is slow with slow fire
Fry to ripe, taking-up, cooling；
(2) by it is described proportioning weigh camellia oleosa seeds, Perilla frutescens, the seed of Oriental arborvitae, dessert almond, japanese plum seed, wild walnut meat, peach kernel, juglandis,semen,
Fructus cannabis, mix, shell by the Chinese torreyanut of frying, radish seed, Snakegourd Seed, fructus amomi, fructus alpiniae oxyphyllae with above-mentioned, shell to be not exclusively de-
Shell, ensure shell-containing rate 28% or so, shell-containing rate is too low to be not easy fuel-displaced, is squeezed with ZX10 screw oil expellers fuel-displaced, obtains oil
It is standby with press cake slag；
(3) alcohol reflux that above-mentioned press cake slag concentration is 80% is extracted twice, 1.5 hours every time, merges extract solution, mistake
Filter, filtrate recycling ethanol, thick paste is concentrated under reduced pressure into, extract powder is made in spray drying, standby；
(4) extract powder that step (3) prepares is added in the oil of step (2) preparation, emulsifying agent is added, from circulation pipe
Formula colloid mill, by colloidal grinding, produce traditional Chinese medicine ingredients；
(5) after polyglycerol ester mixing being added in above-mentioned traditional Chinese medicine ingredients, western medicine composition, P-hydroxybenzoic acid first are sequentially added
Ester, sorbierite, are made soft capsule, produce.
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| CN105639391A (en) * | 2015-12-29 | 2016-06-08 | 中粮集团有限公司 | Drink having bowel-relaxing function and application of drink |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1879739A (en) * | 2006-05-15 | 2006-12-20 | 孙书杰 | Chinese medicinal preparation for treating constipation |
| CN101103811A (en) * | 2007-08-09 | 2008-01-16 | 修正药业集团股份有限公司 | Health food capable of relaxing the bowels |
| CN101703225A (en) * | 2009-10-27 | 2010-05-12 | 吕学栋 | Compound five-kernel composition with effect of relaxing bowel |
| CN103768481A (en) * | 2012-10-19 | 2014-05-07 | 李征 | Traditional Chinese medicinal formula for treating constipation |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1879739A (en) * | 2006-05-15 | 2006-12-20 | 孙书杰 | Chinese medicinal preparation for treating constipation |
| CN101103811A (en) * | 2007-08-09 | 2008-01-16 | 修正药业集团股份有限公司 | Health food capable of relaxing the bowels |
| CN101703225A (en) * | 2009-10-27 | 2010-05-12 | 吕学栋 | Compound five-kernel composition with effect of relaxing bowel |
| CN103768481A (en) * | 2012-10-19 | 2014-05-07 | 李征 | Traditional Chinese medicinal formula for treating constipation |
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