CN106617038B - Health food composition for improving male frequent micturition and urinary incontinence and preparation method and application thereof - Google Patents
Health food composition for improving male frequent micturition and urinary incontinence and preparation method and application thereof Download PDFInfo
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Abstract
The invention discloses a health food composition for improving male frequent micturition and urinary incontinence, a preparation method and application thereof, and belongs to the technical field of health foods. The composition of the invention comprises the following raw material components in parts by weight: 5-20 parts of rape pollen, 2-5 parts of pumpkin seeds and 0.5-3 parts of fructus psoraleae extract; or 5-20 parts of rape pollen, 0.4-5 parts of pumpkin seed oil, 0.4-4 parts of pumpkin seed water extract, 0.0175-0.0702 parts of zinc gluconate, 0.5-3 parts of fructus psoraleae extract and 0.5-3 parts of diaphragma juglandis water extract. The invention adopts a unique extraction method, has high utilization rate of effective components, small waste, good effect and no toxic or side effect.
Description
Technical Field
The invention relates to a health-care food composition, in particular to a health-care food composition for improving male frequent micturition and urinary incontinence, a preparation method and application thereof, belonging to the technical field of health-care foods.
Background
Due to the high incidence of prostate diseases, various countries have developed the research and development of the drugs, wherein the drugs mainly used for treating prostate diseases are "Baoretherapy" in the Moshadong drug, and "Hale" in the Shangen drug and "Duoduohua" in the Peproui drug. Prostatitis and prostatic hyperplasia are mainly treated by Chinese patent medicines, and the main varieties are 'sunitong' of Nanjing Meirui, 'Qianlikang' of Kangbei, 'Uritong' of Evers (Germany), and 'cystine' of Fink (Germany). The health food does not improve the function of the prostate, so the similar products in the market are fewer at present. Although the traditional medicines have obvious effect of improving the symptoms of the prostate diseases, the traditional medicines have potential toxicity after being eaten for a long time, people tend to apply natural components more and more along with continuous discovery of pharmacological and pharmacodynamic mechanisms of new resource foods, China has rich resources, and the efficacy and the safety of the traditional medicines are clear. Therefore, the natural and efficient natural raw materials are found to be a necessary trend.
The traditional Chinese medicine considers that kidneys govern water, kidneys control two yin and govern two bowels, the kidneys and the urinary bladder are in exterior and interior, the opening and closing of the urinary bladder are related to the excretion of urine, the opening and closing of the urinary bladder depends on the gasification of the kidneys, the normal gasification of the kidneys leads to the normal opening and closing of the urinary bladder and the discharge of turbid liquid, and if the gasification of the kidneys is frequent, the opening and closing of the urinary bladder are affected, so that the opening and closing of the urinary bladder are not favorable, and symptoms such as scanty urine, edema and the like are caused; or the bladder is not restricted, and polyuria and enuresis are caused. The preponderance or decline of kidney qi directly affects the qi transformation and opening and closing of the urinary bladder, resulting in the bladder opening and closing being unfavorable or the bladder being unable to restrict, and with symptoms of polyuria and enuresis.
Frequent urination and urinary incontinence are among the common clinical symptoms of the middle-aged and the elderly men. Urinary incontinence is involuntary urination. Uncontrolled urinary incontinence can occur if the intravesical pressure exceeds the pressure required to seal the urethra. Is a common symptom of dysuria, is essentially the manifestation of bladder reservoir dysfunction, and is not an independent disease. But often affects the normal life of the patient, reduces the life quality of the patient, particularly increases the number of urination at night, seriously affects the sleep of the patient, even can cause anxiety and depression, and can also increase the occurrence probability of cardiovascular and cerebrovascular diseases.
The prostate is a male reproductive organ, the anatomical part is special, the medicine is difficult to enter and spread to the periphery, and the traditional Chinese and western medicine treatment feels very troublesome. At present, except physical therapy and prostate massage, drug therapy is indispensable. The therapeutic drugs comprise antibiotics, alpha-receptor blockers, 5 alpha reductase inhibitors, non-steroidal anti-inflammatory agents and the like, although the therapeutic drugs are various, the curative effect is not ideal, the drugs can only inhibit but can not eradicate, the recurrence rate is high, western medicines have certain side effects, the used raw materials are expensive, and the preparation method is complex. Literature queries that the development and maintenance of the physiological state of the prostate depends on the presence of sufficient androgen, especially androgen and estrogen balance, in the body, while the pathogenesis of prostatic hypertrophy is associated with dysregulation and control of the endocrine system. More than 20 amino acids such as glutamic acid, proline, etc. contained in rape pollen can improve the blood circulation of prostate tissue, relieve edema, and relieve urethral obstruction caused by prostatic hyperplasia. The flavonoids have strong antioxidant function and are also used as a key for treating prostatic hyperplasia. The flavonol in pollen has effects of resisting arteriosclerosis, reducing blood lipid and cholesterol, relieving pain, resisting radiation, treating constipation, etc., has therapeutic efficiency of 90% for prostatitis, and can prevent prostatic hyperplasia and prostate dysfunction, and can be used for treating varicose ulcer. The rape pollen can enhance the strength of capillary vessels and reduce blood fat, and has curative effects on diabetes, anemia, constipation, cancer prevention and cancer resistance, and the like. Recent studies have found that pumpkin seeds and pumpkin seeds can also be used for treating urinary system diseases associated with Benign Prostatic Hypertrophy (BPH).
Therefore, the invention researches the etiology and pathogenesis of prostatitis and prostatic hyperplasia on the basis of treatment based on syndrome differentiation, aims to improve the male frequency of micturition and the male incontinence of urine, and selects the raw materials of the health food for improving the male frequency of micturition and the male incontinence of urine to be natural extracts of rape pollen, pumpkin seeds and the like according to the theoretical research of modern pharmacology and efficacy and the actual efficacy research of each raw material, is safe and nontoxic, is supplemented with other medicinal materials to enhance the curative effect, and is the natural raw material with the best effect of improving the male frequency of micturition, the male incontinence of urine and other symptoms. The inventor finally determines the following technical scheme of the invention through repeated experiments, summarization and improvement, and obtains more ideal treatment effect.
One possible technical solution is: a health food composition for improving male pollakisuria and urinary incontinence and application thereof are characterized in that: the feed consists of the following raw material components: 5-20 parts of rape pollen and 5-10 parts of pumpkin seeds. The pumpkin seeds and the rape pollen are selected to have synergistic effect. The treatment method comprises the following steps: the rape pollen is sterilized at high temperature, the pumpkin seeds are cooked and then crushed, and the pumpkin seeds are crushed and then prepared into powder according to a proportion.
The disadvantages are as follows: 1. high-temperature sterilization easily destroys the activity of rape pollen. 2. The components are single.
One possible technical solution is: a health food composition for improving male pollakisuria and urinary incontinence and application thereof are characterized in that: the feed consists of the following raw material components: 10-15 parts of rape pollen, 2-10 parts of pumpkin seed oil and 0.0175-0.0702 part of zinc gluconate. The treatment method comprises the following steps: rape pollen is sterilized at high temperature, and pumpkin seeds are directly squeezed to obtain pumpkin seed oil and pumpkin seed oil.
The disadvantages are as follows: 1. high-temperature sterilization easily destroys the activity of rape pollen. 2. The direct squeezing method has the advantages of simple process operation, simple and complicated production equipment, flexible production scale and suitability for the production of various vegetable oils, but the squeezing method has the defects of low oil yield, large labor force and low production efficiency. 3. The cake after oil extraction is not better utilized, and energy is wasted.
Disclosure of Invention
The invention aims to provide a health-care food composition for improving male frequent micturition and urinary incontinence, and a preparation method and application thereof.
In order to achieve the purpose, the invention adopts the following technical means:
the invention provides a health-care food composition for improving male frequent micturition and urinary incontinence, which is prepared from the following raw material medicines in parts by weight: 5-20 parts of rape pollen, 2-5 parts of pumpkin seeds and 0.5-3 parts of fructus psoraleae extract; preferably, the traditional Chinese medicine is prepared from the following raw material medicines in parts by weight: 10 parts of rape pollen, 2.5 parts of pumpkin seeds and 1.5 parts of fructus psoraleae extract.
Further, the present invention provides a preparation method for the above health food composition, comprising the steps of:
(1) sterilization
Performing sterilization treatment on rape pollen, then drying, crushing and sieving to obtain a material A for later use;
(2) aging
Curing pumpkin seeds and pumpkin seeds, crushing, and sieving to obtain B, C materials respectively for later use;
(3) ultra-high pressure extraction
Extracting fructus Psoraleae by ultra-high pressure extraction to obtain fructus Psoraleae extract, filtering, evaporating to dryness, and pulverizing to obtain material D;
(4) mixing
Weighing A, B, C, D four materials according to the formula, and mixing well to obtain the final product.
Wherein, the sterilization treatment in the step (1) is preferably low-temperature sterilization treatment; the drying is low-temperature drying; and the sieving is to sieve the mixture by a sieve of 80-100 meshes.
Preferably, the sieving in the step (2) is 80-100 mesh sieving.
Wherein, preferably, the extraction pressure of the ultrahigh pressure extraction method in the step (3) is 100Mpa, the extracting solution is 60vt% ethanol, and the weight ratio of liquid to solid is 90: 1.
the invention also provides another health-care food composition for improving the male frequent micturition and the male incontinence, which is prepared from the following raw material medicines in parts by weight: 5-20 parts of rape pollen, 0.4-5 parts of pumpkin seed oil, 0.4-4 parts of pumpkin seed water extract, 0.0175-0.0702 parts of zinc gluconate, 0.5-3 parts of fructus psoraleae extract and 0.5-3 parts of diaphragma juglandis water extract; preferably, the traditional Chinese medicine is prepared from the following raw material medicines in parts by weight: 10 parts of rape pollen, 2.5 parts of pumpkin seed oil, 2.5 parts of pumpkin seed water extract, 0.0351 parts of zinc gluconate, 1.5 parts of fructus psoraleae extract and 1.5 parts of diaphragma juglandis water extract.
Further, the present invention provides a preparation method for the above health food composition, comprising the steps of:
(1) sterilization
Performing sterilization treatment on rape pollen, then drying, crushing and sieving to obtain a material A for later use;
(2) cold pressing for extraction
Peeling pumpkin seeds, taking the seeds, and squeezing the pumpkin seeds to obtain pumpkin seed oil, namely the material B and a squeezed pumpkin seed cake for later use;
husking pumpkin seeds, taking out seeds, and squeezing the pumpkin seeds to obtain pumpkin seed oil, namely the material C and a squeezed pumpkin seed cake for later use;
(3) water extraction
Extracting the squeezed pumpkin seed cake, pumpkin seed cake and diaphragma juglandis respectively by a water extraction method, filtering, concentrating and drying to respectively obtain a pumpkin seed water extract D, a pumpkin seed water extract E and a diaphragma juglandis water extract F for later use;
(4) ultra-high pressure extraction
Extracting fructus Psoraleae by ultra-high pressure extraction to obtain fructus Psoraleae extract, filtering, evaporating to dryness, and pulverizing to obtain material G;
(5) mixing
Weighing seven materials A-G and zinc gluconate according to the formula, mixing uniformly, and granulating to obtain the final product.
Wherein, the sterilization treatment in the step (1) is preferably low-temperature sterilization treatment; the drying is low-temperature drying; and the sieving is to sieve the mixture by a sieve of 80-100 meshes.
Preferably, the pumpkin seed kernel oil pressing in the step (2) is cold pressing by using an oil press, the temperature of a chamber of the oil press is adjusted to be 70 ℃, the pressure is adjusted to be 3.5Mpa, the rotating speed is adjusted to be 36r/min, and the process is repeated for 3-4 times.
Preferably, the oil pressing of the pumpkin seeds in the step (2) is cold pressing by using an oil press, the temperature of a chamber of the oil press is adjusted to be 80 ℃, the pressure is adjusted to be 3.6Mpa, the rotating speed is adjusted to be 36r/min, and the operation is repeated for 3-4 times.
Wherein, preferably, the extraction temperature of the water extraction in the step (3) is 100 ℃, the extraction time is 1 hour, and the weight ratio of the material liquid is 1: 10-1: 20.
wherein, preferably, the extraction pressure of the ultrahigh pressure extraction method in the step (4) is 100Mpa, the extracting solution is 60vt% ethanol, and the weight ratio of liquid to solid is 90: 1.
the health food composition can be used for preparing health foods for improving the male frequent micturition and the male incontinence.
The functional effects of the components in the formula of the invention are as follows:
rape pollen: the rape is an agricultural economic crop planted in large area in China, the powder source is wide, rape flowers are adopted as northern crops, the quality is pure, the rape pollen is rich in nutrient substances, the rape is capable of tonifying the kidney, strengthening the body and strengthening the waist, and the brass alcohol content is high, so that the rape pollen has the effects of resisting atherosclerosis, treating venous ulcer, reducing cholesterol and resisting radiation, and has a remarkable curative effect on chronic prostatitis.
Pumpkin seeds: pumpkin (cucurbita moschata Duch.) is also called guava, cucurbita sativa, etc., and is an annual herb plant of the cucurbitaceae family. The pumpkin has high nutritive value, contains various functional components besides various nutrient components such as free amino acids, carotene, VB, VC, mannitol and the like, and has more researches on pumpkin at home and relatively late research on pumpkin seeds. The pumpkin seeds are mature seeds of pumpkins, and contain rich unsaturated fatty acid, vitamins, bioflavonoids, pumpkin polysaccharide, mineral substances and the like, and the functional components have wide and important biological functions and have good research and application values. The pumpkin seed oil is oil extracted from fully mature pumpkin seeds, is natural and dark green, is fresh and non-greasy, has a nutlet taste, is rich in nutrient components, can provide required nutrient substances for a human body, and is one of high-content nutrient oils. The pumpkin seed oil is obtained by squeezing or extracting pumpkin seeds, and contains oleic acid, linoleic acid, linolenic acid, palmitic acid, stearic acid, arachidic acid, vaccenic acid, erucic acid and other unsaturated fatty acids, wherein the total unsaturated fatty acids account for 74.9% of the total fatty acids, and the content of the oleic acid and the linoleic acid accounts for 35% -50% of the dry weight of the pumpkin seeds. Unsaturated fatty acids contain polyunsaturated fatty acids (PUFA) as the main component; the pumpkin seed oil also contains abundant vitamins such as fat-soluble VE and a certain amount of phylloquinone-vitamin K; the pumpkin seed oil is rich in mineral substances, wherein zinc, magnesium, iron, selenium and the like have special biological effects. Particularly, phytosterol contained therein can treat urinary system disease symptoms of BPH patients, and in conventional medicine, the seeds thereof are used as anthelmintic, emollient, diuretic and tonic, and a tea made from the seeds thereof can treat prostatic hypertrophy. Therefore, the pumpkin seeds have good development prospect in the field of health-care food.
Pumpkin seeds: cucurbita pepo L, also known as Cucurbita aurantia willd, Cucurbita melopepo L. The eating of zucchini has been described by ancient people since the time of the first century, and it has been known since then in China and other countries. The medical scientists in the past consistently acknowledged that it has six functions: nourishing and caring skin, nourishing heart and tranquilizing mind, invigorating stomach and moistening lung, resisting bacteria and strengthening body constitution, loosening bowel to relieve constipation, and relieving chest stuffiness. In addition, it can be used for adjuvant treatment of edema, abdominal distention, polydipsia, skin sore, nephritis, and ascites due to liver cirrhosis. In the conventional medicine, the seeds thereof are used as anthelmintic, emollient, diuretic and tonic, and a tea prepared from the seeds thereof can treat prostatic hypertrophy. There are currently examples of the use of zucchini seeds for the treatment of urological disorders associated with Benign Prostatic Hypertrophy (BPH). The principal ingredients of the cucurbita pepo seeds are phytosterols, and the active compounds are delta 5, delta 7 and delta 8-sterols, wherein the delta 7-sterol is a key active ingredient with high content in the cucurbita pepo seeds and is considered to be used for treating benign prostatic hyperplasia, a small amount of delta 5 and delta 8-sterols also exist in the cucurbita pepo seeds and play a role, and high content of carotenoid, polyunsaturated fatty acid and fat-soluble vitamin also have certain active effects, so that the cucurbita pepo seeds can treat urinary system disease symptoms of BPH patients, and have good development prospects in the field of health foods. At the end of the 19 th century, pumpkin seed oil was used for the treatment of urinary tract disorders. Animal studies have shown that water extracts of cucurbita pepo seeds may improve bladder and urethral function.
Psoralea fruit: fructus Psoraleae is the dried mature fruit of Psoralea corylifolia (Psoralea coriyli-folia L.) belonging to Leguminosae, and has the effects of tonifying kidney, supporting yang, receiving qi, and relieving diarrhea, as recorded in Legong Baozi moxibustion theory. The traditional Chinese medicine is used for treating the symptoms of kidney deficiency, cold diarrhea, spermatorrhea, frequent micturition, cold pain of waist and knees and the like.
Splitting the core wood: the diaphragma juglandis is a wood diaphragm in a kernel of Juglans regia (Juglans regia L.) of Juglandaceae, and is also called walnut shell, walnut cracker, walnut diaphragm and walnut diaphragm. The traditional Chinese medicine considers that the medicine has bitter, astringent and even taste, enters spleen and kidney channels, has the effects of strengthening spleen and kidney, inducing diuresis and clearing heat, treating gonorrhea, hematuria, summer heat and diarrhea and the like, and is suitable for treating enuresis, metrorrhagia, metrostaxis, deafness, spermatorrhea, frequent micturition, leukorrhagia and the like. The walnut diaphragma juglandis is soaked in water for drinking, has the functions of tonifying kidney and arresting seminal emission, also has the effects on hyperhidrosis, frequent micturition, enuresis, kidney deficiency and nocturnal emission, dental ulcer, gingival bleeding, frequent urination and the like, and has certain antibacterial activity.
Zinc gluconate: zinc is present in numerous enzyme systems, such as carbonic anhydrase, respiratory enzyme, lactic acid dehydro acid, superoxide dismutase, alkaline phosphatase, DNA and RNA polymerase, and the like, and is essential for the synthesis of nucleic acids, proteins, carbohydrates and the utilization of vitamin A. Zinc is also an intrinsic component and functional unit of adrenocortical hormone, and the amount of zinc in the prostate is 10 times greater than in other organs, and prostate hyperplasia is associated with zinc deficiency.
The raw material medicaments used in the invention all meet the quality standard requirements of health-care food.
Compared with the prior art, the invention has the beneficial effects that:
the first formula and the preparation method thereof (5-20 parts of rape pollen, 2-5 parts of pumpkin seeds and 0.5-3 parts of fructus psoraleae): on the basis of improving male prostate diseases by combining rape pollen and pumpkin seeds, the health food composition is added with pumpkin seeds and pumpkin seeds for synergistic action, and is added with a fructus psoraleae extract for improving the curative effect, so that the symptoms of male frequent micturition and urinary incontinence can be effectively improved; in addition, the unique preparation method further enhances the health-care efficacy of the food, such as: the low-temperature sterilization method adopted in the step (2) ensures the shape and the vitality of the rape pollen; extracting the fructus psoraleae by using an ultrahigh pressure extraction method adopted in the step (4) to obtain psoralen to the maximum extent; the raw materials have simple preparation process and easy operation, and can be directly taken by patients after being prepared into powder.
A second formula and a preparation method thereof (5-20 parts of rape pollen, 0.4-5 parts of pumpkin seed oil, 0.4-4 parts of pumpkin seed water extract, 0.0175-0.0702 parts of zinc gluconate, 0.5-3 parts of fructus psoraleae and 0.5-3 parts of diaphragma juglandis): on the basis of the formula I, pumpkin seeds and pumpkin seeds are further processed into seed oil and water extract, so that the effective components of the pumpkin seeds and the pumpkin seeds can be better absorbed by a human body; the zinc gluconate and the diaphragma juglandis added simultaneously further enhance the curative effect of the health food composition. In addition, the unique preparation method further enhances the health-care efficacy of the food, such as: the low-temperature sterilization method adopted in the step (2) ensures the shape and the vitality of the rape pollen; the pumpkin seed oil and the pumpkin seed oil are obtained by adopting a cold pressing method, so that the higher oil yield is ensured, and trace nutrient substances in the seed oil can be kept; step (4) further extracting the squeezed seed cake with water to obtain effective substances, fully utilizing raw materials and reducing waste to the minimum; the psoralea fruit ultrahigh pressure extraction method adopted in the step (5) improves the extraction rate of psoralen to the maximum extent, all the substances are mixed and prepared into tablets, so that the tablets are convenient for patients to take, the materials are fully utilized, and the treatment effect is achieved.
The invention researches the pathogenesis of male pollakisuria and urinary incontinence on the basis of treatment based on syndrome differentiation, selects raw materials, adopts a unique extraction method to prepare the health food for improving the prostate disease, and has the advantages of high utilization rate of effective components, small waste, good effect and no toxic or side effect. After the raw materials are processed in a series of ways, the materials are mixed to prepare powder or tablets, which is more beneficial for patients to take and obtains more ideal treatment effect.
Detailed description of the invention
The invention will be further described with reference to specific comparative examples and examples, and the advantages and features of the invention will become more apparent as the description proceeds. These examples are illustrative only and do not limit the scope of the present invention in any way. It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention, and that such changes and modifications may be made without departing from the spirit and scope of the invention.
Comparative example 1
(1) Sterilization
Sterilizing rape pollen at low temperature, drying at low temperature, pulverizing, and sieving with 100 mesh sieve to obtain material A;
(2) aging
Curing pumpkin seeds, crushing the pumpkin seeds, and sieving the pumpkin seeds with a 100-mesh sieve to obtain a material B for later use;
(3) mixing
Weighing 10g of the material A and 5g of the material B according to the formula ratio, and uniformly mixing to obtain the material.
Comparative example 2
(1) Sterilization
Sterilizing rape pollen at low temperature, drying at low temperature, pulverizing, and sieving with 100 mesh sieve to obtain material A;
(2) aging
Curing pumpkin seeds and pumpkin seeds, crushing, and sieving with a 100-mesh sieve to obtain B, C materials respectively for later use;
(3) mixing
Weighing 10g of the material A, 2.5g of the material B and 2.5g of the material C according to the formula ratio, and uniformly mixing to obtain the material.
Example 1
(1) Sterilization
Sterilizing rape pollen at low temperature, drying at low temperature, pulverizing, and sieving with 100 mesh sieve to obtain material A;
(2) aging
Curing pumpkin seeds and pumpkin seeds, crushing, and sieving with a 100-mesh sieve to obtain B, C materials respectively for later use;
(3) ultra-high pressure extraction
Extracting fructus Psoraleae with ultra-high pressure extraction under 100Mpa with 60vt% ethanol solution at a liquid-solid weight ratio of 90: 1, obtaining a fructus psoraleae extract, filtering, evaporating to dryness, and crushing to obtain a material D for later use;
(4) mixing
Weighing 5g of the material A, 4.25g of the material B, 4.25g of the material C and 3g of the material D according to the formula ratio, and uniformly mixing to obtain the material.
Example 2
(1) Sterilization
Sterilizing rape pollen at low temperature, drying at low temperature, pulverizing, and sieving with 100 mesh sieve to obtain material A;
(2) aging
Curing pumpkin seeds and pumpkin seeds, crushing, and sieving with a 100-mesh sieve to obtain B, C materials respectively for later use;
(3) ultra-high pressure extraction
Extracting fructus Psoraleae with ultra-high pressure extraction under 100Mpa with 60vt% ethanol solution at a liquid-solid weight ratio of 90: 1, obtaining a fructus psoraleae extract, filtering, evaporating to dryness, and crushing to obtain a material D for later use;
(4) mixing
Weighing 12g of the material A, 2g of the material B, 2g of the material C and 0.5g of the material D according to the formula ratio, and uniformly mixing to obtain the material.
Example 3
(1) Sterilization
Sterilizing rape pollen at low temperature, drying at low temperature, pulverizing, and sieving with 100 mesh sieve to obtain material A;
(2) aging
Curing pumpkin seeds and pumpkin seeds, crushing, and sieving with a 100-mesh sieve to obtain B, C materials respectively for later use;
(3) ultra-high pressure extraction
Extracting fructus Psoraleae with ultra-high pressure extraction under 100Mpa with 60vt% ethanol solution at a liquid-solid weight ratio of 90: 1, obtaining a fructus psoraleae extract, filtering, evaporating to dryness, and crushing to obtain a material D for later use;
(4) mixing
Weighing 10g of the material A, 2.5g of the material B, 2.5g of the material C and 1.5g of the material D according to the formula ratio, and uniformly mixing to obtain the material.
Comparative example 3
(1) Sterilization
Sterilizing rape pollen at low temperature, drying at low temperature, pulverizing, and sieving with 100 mesh sieve to obtain material A;
(2) cold pressing for extraction
Peeling Cucurbita pepo seeds, taking out seeds, cold pressing the Cucurbita pepo seeds by using an oil press, adjusting the temperature of a barrel of the oil press to 80 ℃, the pressure to 3.6Mpa and the rotating speed to 36r/min, and repeating for 4 times to obtain Cucurbita pepo seed oil, namely a material B and a pressed Cucurbita pepo seed cake for later use;
(3) water extraction
Extracting the squeezed summer squash seed cake by a water extraction method, wherein the extraction temperature is 100 ℃, the extraction time is 1 hour, and the weight ratio of the material liquid to the liquid is 1: 10, filtering, concentrating and drying to respectively obtain pumpkin seed water extract C for later use;
(4) mixing
Weighing 10g of the material A, 5g of the material B, 5g of the material C and 0.0351g of zinc gluconate according to the formula ratio, uniformly mixing, and granulating to obtain the compound feed.
Comparative example 4
(1) Sterilization
Sterilizing rape pollen at low temperature, drying at low temperature, pulverizing, and sieving with 100 mesh sieve to obtain material A;
(2) cold pressing for extraction
Peeling semen Cucurbitae, collecting seed kernel, cold pressing semen Cucurbitae with oil press, adjusting the temperature of oil press chamber to 70 deg.C, pressure to 3.5Mpa, and rotation speed to 36r/min, repeating for 4 times to obtain semen Cucurbitae oil, material B, and pressed semen Cucurbitae cake;
peeling Cucurbita pepo seeds, taking out seeds, cold pressing the Cucurbita pepo seeds by using an oil press, adjusting the temperature of a barrel of the oil press to 80 ℃, the pressure to 3.6Mpa and the rotating speed to 36r/min, and repeating for 4 times to obtain Cucurbita pepo seed oil, namely a material C and a pressed Cucurbita pepo seed cake for later use;
(3) water extraction
Extracting the pressed pumpkin seed cake and the pressed pumpkin seed cake by a water extraction method respectively at the extraction temperature of 100 ℃ for 1 hour, wherein the weight ratio of the material liquid to the liquid is 1: 10, filtering, concentrating and drying to respectively obtain a pumpkin seed water extract D and a pumpkin seed water extract E for later use;
(4) mixing
Weighing 10g of the material A, 2.5g of the material B, 2.5g of the material C, 2.5g of the material D, 2.5g of the material E and 0.0351g of zinc gluconate according to the formula ratio, uniformly mixing, and granulating to obtain the compound feed.
Comparative example 5
(1) Sterilization
Sterilizing rape pollen at low temperature, drying at low temperature, pulverizing, and sieving with 100 mesh sieve to obtain material A;
(2) cold pressing for extraction
Peeling semen Cucurbitae, collecting seed kernel, cold pressing semen Cucurbitae with oil press, adjusting the temperature of oil press chamber to 70 deg.C, pressure to 3.5Mpa, and rotation speed to 36r/min, repeating for 4 times to obtain semen Cucurbitae oil, material B, and pressed semen Cucurbitae cake;
peeling Cucurbita pepo seeds, taking out seeds, cold pressing the Cucurbita pepo seeds by using an oil press, adjusting the temperature of a barrel of the oil press to 80 ℃, the pressure to 3.6Mpa and the rotating speed to 36r/min, and repeating for 4 times to obtain Cucurbita pepo seed oil, namely a material C and a pressed Cucurbita pepo seed cake for later use;
(3) water extraction
Extracting the pressed pumpkin seed cake, the pressed pumpkin seed cake and the pressed common pistachio herb by adopting a water extraction method, wherein the extraction temperature is 100 ℃, the extraction time is 1 hour, and the weight ratio of material liquid is 1: 10, filtering, concentrating and drying to respectively obtain a pumpkin seed water extract D, a pumpkin seed water extract E and a diaphragma juglandis water extract F for later use;
(4) mixing
Weighing 10g of the material A, 2.5g of the material B, 2.5g of the material C, 2.5g of the material D, 2.5g of the material E, 3g of the material F and 0.0351g of zinc gluconate according to the formula, uniformly mixing, and granulating to obtain the finished product.
Comparative example 6
(1) Sterilization
Sterilizing rape pollen at low temperature, drying at low temperature, pulverizing, and sieving with 100 mesh sieve to obtain material A;
(2) cold pressing for extraction
Peeling semen Cucurbitae, collecting seed kernel, cold pressing semen Cucurbitae with oil press, adjusting the temperature of oil press chamber to 70 deg.C, pressure to 3.5Mpa, and rotation speed to 36r/min, repeating for 4 times to obtain semen Cucurbitae oil, material B, and pressed semen Cucurbitae cake;
peeling Cucurbita pepo seeds, taking out seeds, cold pressing the Cucurbita pepo seeds by using an oil press, adjusting the temperature of a barrel of the oil press to 80 ℃, the pressure to 3.6Mpa and the rotating speed to 36r/min, and repeating for 4 times to obtain Cucurbita pepo seed oil, namely a material C and a pressed Cucurbita pepo seed cake for later use;
(3) water extraction
Extracting the pressed pumpkin seed cake and the pressed pumpkin seed cake by a water extraction method respectively at the extraction temperature of 100 ℃ for 1 hour, wherein the weight ratio of the material liquid to the liquid is 1: 10, filtering, concentrating and drying to respectively obtain a pumpkin seed water extract D and a pumpkin seed water extract E for later use;
(4) ultra-high pressure extraction
Extracting fructus Psoraleae with ultra-high pressure extraction under 100Mpa with 60vt% ethanol solution at a liquid-solid weight ratio of 90: 1, obtaining a fructus psoraleae extract, filtering, evaporating to dryness, and crushing to obtain a material F for later use;
(5) mixing
Weighing 10g of the material A, 2.5g of the material B, 2.5g of the material C, 2.5g of the material D, 2.5g of the material E, 3g of the material F and 0.0351g of zinc gluconate according to the formula, uniformly mixing, and granulating to obtain the finished product.
Example 4
(1) Sterilization
Sterilizing rape pollen at low temperature, drying at low temperature, pulverizing, and sieving with 100 mesh sieve to obtain material A;
(2) cold pressing for extraction
Peeling semen Cucurbitae, collecting seed kernel, cold pressing semen Cucurbitae with oil press, adjusting the temperature of oil press chamber to 70 deg.C, pressure to 3.5Mpa, and rotation speed to 36r/min, repeating for 4 times to obtain semen Cucurbitae oil, material B, and pressed semen Cucurbitae cake;
peeling Cucurbita pepo seeds, taking out seeds, cold pressing the Cucurbita pepo seeds by using an oil press, adjusting the temperature of a barrel of the oil press to 80 ℃, the pressure to 3.6Mpa and the rotating speed to 36r/min, and repeating for 4 times to obtain Cucurbita pepo seed oil, namely a material C and a pressed Cucurbita pepo seed cake for later use;
(3) water extraction
Extracting the pressed pumpkin seed cake, the pressed pumpkin seed cake and the pressed common pistachio herb by adopting a water extraction method, wherein the extraction temperature is 100 ℃, the extraction time is 1 hour, and the weight ratio of material liquid is 1: 10, filtering, concentrating and drying to respectively obtain a pumpkin seed water extract D, a pumpkin seed water extract E and a diaphragma juglandis water extract F for later use;
(4) ultra-high pressure extraction
Extracting fructus Psoraleae with ultra-high pressure extraction under 100Mpa with 60vt% ethanol solution at a liquid-solid weight ratio of 90: 1, obtaining a fructus psoraleae extract, filtering, evaporating to dryness, and crushing to obtain a material G for later use;
(5) mixing
Weighing 14G of the material A, 2G of the material B, 2G of the material C, 2G of the material D, 2G of the material E, 0.5G of the material F, 0.5G of the material G and 0.0175G of zinc gluconate according to the formula, uniformly mixing, and granulating to obtain the finished product.
Example 5
(1) Sterilization
Sterilizing rape pollen at low temperature, drying at low temperature, pulverizing, and sieving with 100 mesh sieve to obtain material A;
(2) cold pressing for extraction
Peeling semen Cucurbitae, collecting seed kernel, cold pressing semen Cucurbitae with oil press, adjusting the temperature of oil press chamber to 70 deg.C, pressure to 3.5Mpa, and rotation speed to 36r/min, repeating for 4 times to obtain semen Cucurbitae oil, material B, and pressed semen Cucurbitae cake;
peeling Cucurbita pepo seeds, taking out seeds, cold pressing the Cucurbita pepo seeds by using an oil press, adjusting the temperature of a barrel of the oil press to 80 ℃, the pressure to 3.6Mpa and the rotating speed to 36r/min, and repeating for 4 times to obtain Cucurbita pepo seed oil, namely a material C and a pressed Cucurbita pepo seed cake for later use;
(3) water extraction
Extracting the pressed pumpkin seed cake, the pressed pumpkin seed cake and the pressed common pistachio herb by adopting a water extraction method, wherein the extraction temperature is 100 ℃, the extraction time is 1 hour, and the weight ratio of material liquid is 1: 10, filtering, concentrating and drying to respectively obtain a pumpkin seed water extract D, a pumpkin seed water extract E and a diaphragma juglandis water extract F for later use;
(4) ultra-high pressure extraction
Extracting fructus Psoraleae with ultra-high pressure extraction under 100Mpa with 60vt% ethanol solution at a liquid-solid weight ratio of 90: 1, obtaining a fructus psoraleae extract, filtering, evaporating to dryness, and crushing to obtain a material G for later use;
(5) mixing
Weighing 5G of the material A, 3.5G of the material B, 3.5G of the material C, 3.5G of the material D, 3.5G of the material E, 2G of the material F, 2G of the material G and 0.0702G of zinc gluconate according to the formula, uniformly mixing, and granulating to obtain the compound feed.
Example 6
(1) Sterilization
Sterilizing rape pollen at low temperature, drying at low temperature, pulverizing, and sieving with 100 mesh sieve to obtain material A;
(2) cold pressing for extraction
Peeling semen Cucurbitae, collecting seed kernel, cold pressing semen Cucurbitae with oil press, adjusting the temperature of oil press chamber to 70 deg.C, pressure to 3.5Mpa, and rotation speed to 36r/min, repeating for 4 times to obtain semen Cucurbitae oil, material B, and pressed semen Cucurbitae cake;
peeling Cucurbita pepo seeds, taking out seeds, cold pressing the Cucurbita pepo seeds by using an oil press, adjusting the temperature of a barrel of the oil press to 80 ℃, the pressure to 3.6Mpa and the rotating speed to 36r/min, and repeating for 4 times to obtain Cucurbita pepo seed oil, namely a material C and a pressed Cucurbita pepo seed cake for later use;
(3) water extraction
Extracting the pressed pumpkin seed cake, the pressed pumpkin seed cake and the pressed common pistachio herb by adopting a water extraction method, wherein the extraction temperature is 100 ℃, the extraction time is 1 hour, and the weight ratio of material liquid is 1: 10, filtering, concentrating and drying to respectively obtain a pumpkin seed water extract D, a pumpkin seed water extract E and a diaphragma juglandis water extract F for later use;
(4) ultra-high pressure extraction
Extracting fructus Psoraleae with ultra-high pressure extraction under 100Mpa with 60vt% ethanol solution at a liquid-solid weight ratio of 90: 1, obtaining a fructus psoraleae extract, filtering, evaporating to dryness, and crushing to obtain a material G for later use;
(5) mixing
Weighing 10G of the material A, 2.5G of the material B, 2.5G of the material C, 2.5G of the material D, 2.5G of the material E, 1.5G of the material F, 1.5G of the material G and 0.0351G of zinc gluconate according to the formula, uniformly mixing, and granulating to obtain the compound.
Experimental example 1
In the experimental example, the experimental observation of the pharmaceutical composition on normal rats and frequent micturition model rats is studied to prove the therapeutic effect of the health food composition for improving the frequent micturition and urinary incontinence of men.
1. Materials and methods
1.1 animals
Wistar rats with the weight of 350-450g are selected and provided by the university of traditional Chinese medicine in Heilongjiang.
1.2 drugs and dosages
The compositions prepared according to comparative examples 1 to 6 and examples 1 to 6 were administered in a dose of 3 g/kg. Control drug: sunitin (tolterodine tartrate tablet), Nanjing Meirui pharmaceutical Co., Ltd., dosage of 0.3 mg/kg.
2. Method of producing a composite material
2.1 Effect of the compositions prepared in comparative examples 1 to 6 and examples 1 to 6 on urination in a frequent urination model rat
Normal male rats were 120 and randomly averaged into 15 groups: sham, model, control (Senecin), comparative examples 1-6, examples 1-6. Performing abdominal anesthesia with sodium pentobarbital, fixing the back, depilating and sterilizing the lower part, cutting a small opening 2cm long along the center of the lower abdomen with a scalpel, searching for the hypogastric nerve, pushing the descending colon and rectum to one side, abutting against the posterior abdominal wall at the center of the mesentery at the moment, separating the hypogastric nerves at two sides, cutting off (only performing incision operation in a sham operation group, without cutting off the nerves), suturing the wound, and normally feeding for 2 weeks. After 2 weeks, the control group, comparative examples 1 to 6 and examples 1 to 6 were administered by gavage with the same dose, the sham operation group and the model group were administered with the same dose of distilled water, the rats were individually placed in rat metabolism cages 1 hour later, and the 1 st urination time, the number of urination times within 2 hours and the change in urine volume within 2 hours of each group of rats were observed, and the experimental results are shown in table 1.
TABLE 1 Effect of the compositions of comparative examples 1-6 and examples 1-6 on urination in rats of the frequent urination model
Compared with the sham operation△P < 0.05, P < 0.01, to model group.
2.2 Effect of the compositions of examples 1-8 on Normal rat urination
Taking 140 normal male rats, randomly and averagely dividing the rats into 14 groups: blank, control, comparative examples 1-6, examples 1-6. Except for normal feeding, the control group, comparative examples 1 to 6, and examples 1 to 6 were administered by gavage daily at the same dose, and the blank group was administered with the same dose of distilled water for 7 days continuously. Day and night urine volume was observed and recorded in rats before and on days 1, 3 and 7 respectively, and the experimental results are shown in table 2.
TABLE 2 Effect of the compositions of comparative examples 1-6 and examples 1-6 on the urination of normal rats
Ratio to blank△P＜0.05，△△P < 0.01, compared to control group P < 0.05.
3. Conclusion
The data results in table 1 show that the time for the model group to urinate 1 st time is shorter than that of the rats in the sham operation group, and the number of times of urination in 2 hours is increased, and the obvious difference is shown, which indicates that the model building is successful. After the rats take the compositions of the groups 1 to 6 of the comparative examples and the groups 1 to 6 of the examples, the frequency and the urgent micturition degree and the urine volume of the rats are reduced, and the rats have obvious difference compared with the model group; it was further observed that the frequency and volume of the urine were lower in the groups of examples 1-3 than in the groups of comparative examples 1-2, the frequency and volume of the urine were lower in the groups of examples 4-6 than in the groups of comparative examples 3-6, and the frequency and volume of the urine were the lowest in the group of example 6, indicating that the components of the formulation of the present invention coordinate with each other to act positively to achieve the desired therapeutic effect. Wherein:
the frequency and volume of urine in the comparative example 2 group are lower than those in the comparative example 1 group, and the frequency and volume of urine in the comparative example 4 group are lower than those in the comparative example 3 group, so that the combination of pumpkin seeds and pumpkin seeds has stronger inhibition effect on prostatic hyperplasia than that of a single component;
the frequency and the volume of urine in the group of example 3 are lower than those in the group of comparative examples 1-2, and the frequency and the volume of urine in the group of comparative examples 5-6 are lower than those in the group of comparative example 4, which shows that the addition of the diaphragma juglandis or the fructus psoraleae has the effect of promoting the drug effect of the composition;
the frequency and volume of urgency of urination in the example 6 group was lower than those in the comparative examples 5-6, indicating that the efficacy of the composition of the present invention is stronger when diaphragma and psoralea are synergistically present than when they are present separately.
The data results in table 2 show that the urine volume of rats after 3 days and 7 days after the administration of the drug to normal rats is significantly different from that before the administration, further proving that the composition of the invention has certain treatment effect on the frequency and the urgent micturition degree and the urine volume.
Experimental example 2 pharmacodynamic test of efficacy of the pharmaceutical composition of the present invention for improving prostate disease
1. Experimental Material
And (3) testing the sample: the compositions prepared according to comparative examples 1 to 6 and examples 1 to 6 were administered in a dose of 2 g/kg. Molding injection: testosterone propionate. Animal species: kunming mouse. Animal sex and number: male, 122 in total. Animal body weight: 18-22 g.
2. Experimental methods
122 male mice are taken and randomly divided into 14 groups according to the body weight, wherein each group comprises 8-10 male mice, and the groups comprise a blank group, a model group, comparative examples 1-6 groups and examples 1-6 groups. Except for normal feeding, except for the blank control group, the mice of each group were injected with testosterone propionate (5mg/kg) 1 time per day; after 1h, groups 1 to 6 of comparative examples and groups 1 to 6 of examples were each subjected to gavage 1 time, and the blank group and the model group were each subjected to the same volume of distilled water for 30 consecutive days. 24h after the last dose, the mice were sacrificed and the prostate was extracted. Calculation of Prostate Index (PI): prostate weight (mg)/mouse body weight 10. The results of the experiment are shown in Table 3.
TABLE 3 Effect of the compositions of comparative examples 1-6 and examples 1-6 on prostate weight and Prostate Index (PI) in mice
Note:△△represents that the comparison with a blank control group P < 0.01, represents that the comparison with a model group P < 0.01, and represents that the comparison with the model group P < 0.05.
3. Conclusion
As can be seen from Table 3, the compositions of comparative examples 1 to 6 and examples 1 to 6 each had an inhibitory effect on prostatic hyperplasia. Further studies have shown that the prostate indices of the groups of examples 1-3 are lower than those of the groups of comparative examples 1-2, the prostate indices of the groups of examples 4-6 are lower than those of the groups of comparative examples 3-6, and the prostate index of the group of example 6 is the lowest, indicating that the components of the formulation of the present invention are mutually coordinated and together play a positive role, achieving the desired therapeutic effect. Wherein:
the prostate index of the group of comparative example 2 is lower than that of the group of comparative example 1, and the prostate index of the group of comparative example 4 is lower than that of the group of comparative example 3, which shows that the combination of pumpkin seeds and pumpkin seeds has stronger inhibition effect on prostate hyperplasia than that of a single component;
the prostate index of the group of example 3 was lower than that of the groups of comparative examples 1-2, and the prostate index of the groups of comparative examples 5-6 was lower than that of the group of comparative example 4, indicating that the addition of diaphragma juglandis or psoralea corylifolia contributes to the efficacy of the composition of the present invention;
the prostate index of the example 6 group was lower than that of the comparative examples 5-6, indicating that the efficacy of rosewood and psoralea was stronger when they were present synergistically in the compositions of the present invention than when they were present separately.
Experimental example 3 clinical study of the pharmaceutical composition of the present invention on male pollakiuria, urgency and urinary incontinence
Frequent micturition and urgent micturition are common diseases, the incidence rate of the diseases is gradually increased with the increase of the age, the pathogenesis is more complex, and an effective treatment method is lacked at present. The frequency and urgency of urination can reach 20-30 times/day without increasing the total amount of urine. The patient feels urgent micturition but does not feel pain, and the daily life of the patient is seriously affected.
1. Clinical data and methods
1.1 clinical data and grouping
60 male patients with frequent and urgent micturition with disease course more than 1 month were selected from 2016 to 9, and randomly divided into 3 groups of 20 persons, namely a control group, an example 3 group and an example 6 group.
1.2 inclusion criteria
Gender is male, the age is 35-55 years, and the number of urination at night is more than 3 on average.
1.3 diagnostic criteria
The traditional Chinese medicine symptoms comprise intolerance of cold, cold limbs, frequent micturition, qi deficiency, weakness, soreness of waist and knees, pale tongue with white fur, and patients with bladder and urethra organic lesions and frequent micturition and urgent micturition caused by tumor, renal failure and the like.
1.4 methods of treatment
The control group adopts conventional western medicine treatment, and racanisodamine tablet is orally taken according to dosage (5 mg/tablet, 2 tablets once, 3 times a day); the composition of example 3 was administered in a dose (25 g/time, three times a day) in the group of example 3, and the composition of example 6 was administered in a dose (25 g/time, three times a day) in the group of example 6.
1.5 Observation index
According to the usual work and rest of the patient, the patient can relieve the urine from getting up to sleep to the next morning, and the urine frequency, the urine volume and the continuous recording are carried out for 7 days. And (6) averaging. The observation is carried out for 1 time respectively before taking medicine, 3 months after taking medicine and after the treatment course is finished.
1.6 Effect assessment
The symptom is completely disappeared to be cured, the symptom is obviously relieved to be effective, the symptom which is relieved but not reach 50 percent is effective, and the symptom which is not relieved or even aggravated is ineffective.
2. Results
TABLE 4 index of frequent nocturia in control group
Note:△p < 0.05 compared to pre-treatment, P < 0.05 compared to 3 months of treatment.
TABLE 5 example 3 group index changes of frequency of nocturia
| Before treatment | The treatment period is 3 months | The treatment period is 6 months | |
| Number of times of urination | 5.8±1.3 | 3.6±1.1△ | 2.2±0.9* |
| Night urine volume (ml) | 738.3±145.3 | 632.5±125.7△ | 440.1±121.4* |
Note:△p < 0.05 compared to pre-treatment, P < 0.05 compared to 3 months of treatment.
TABLE 6 example 6 group index changes in frequency of nocturia
| Before treatment | The treatment period is 3 months | The treatment period is 6 months | |
| Number of times of urination | 5.7±1.3 | 3.1±1.1△ | 2.0±0.9* |
| Night urine volume (ml) | 735.5±132.5 | 622.1±110.8△ | 432.1±115.2* |
Note:△p < 0.05 compared to pre-treatment, P < 0.05 compared to 3 months of treatment.
TABLE 7 comparison of the therapeutic effects of the examples and the control group
Note: p < 0.05 compared to control.
The results show that the control group and the administration group have improved nocturia frequency after taking the medicine, the average nocturia frequency and the nocturia volume are obviously reduced, and the health-care food composition has a certain improvement effect on male urinary frequency and urinary urgency.
Claims (8)
1. A health food composition for improving male pollakisuria and urinary incontinence is characterized by comprising the following raw material components in parts by weight: 5-20 parts of rape pollen, 0.4-5 parts of pumpkin seed oil, 0.4-4 parts of pumpkin seed water extract, 0.0175-0.0702 parts of zinc gluconate, 0.5-3 parts of fructus psoraleae extract and 0.5-3 parts of diaphragma juglandis water extract.
2. A health food composition for improving male pollakisuria and urinary incontinence is characterized by comprising the following raw material components in parts by weight: 10 parts of rape pollen, 2.5 parts of pumpkin seed oil, 2.5 parts of pumpkin seed water extract, 0.0351 parts of zinc gluconate, 1.5 parts of fructus psoraleae extract and 1.5 parts of diaphragma juglandis water extract.
3. A process for preparing a health food composition according to claim 1 or 2, comprising the steps of:
(1) sterilization
Performing sterilization treatment on rape pollen, then drying, crushing and sieving to obtain a material A for later use;
(2) cold pressing for extraction
Peeling pumpkin seeds, taking the seeds, and squeezing the pumpkin seeds to obtain pumpkin seed oil, namely the material B and a squeezed pumpkin seed cake for later use;
husking pumpkin seeds, taking out seeds, and squeezing the pumpkin seeds to obtain pumpkin seed oil, namely the material C and a squeezed pumpkin seed cake for later use;
(3) water extraction
Extracting the squeezed pumpkin seed cake, pumpkin seed cake and diaphragma juglandis respectively by a water extraction method, filtering, concentrating and drying to respectively obtain a pumpkin seed water extract D, a pumpkin seed water extract E and a diaphragma juglandis water extract F for later use;
(4) ultra-high pressure extraction
Extracting fructus Psoraleae by ultra-high pressure extraction to obtain fructus Psoraleae extract, filtering, evaporating to dryness, and pulverizing to obtain material G;
(5) mixing
Weighing seven materials A-G and zinc gluconate according to the parts by weight of the materials in the claim 1 or 2, uniformly mixing and granulating to obtain the product.
4. The production method according to claim 3, wherein the sterilization treatment in step (1) is a low-temperature sterilization treatment; the drying is low-temperature drying; and the sieving is to sieve the mixture by a sieve of 80-100 meshes.
5. The preparation method according to claim 3, wherein the squeezing of the pumpkin seeds in the step (2) is cold pressing by using an oil press, and the temperature of a chamber of the oil press is adjusted to 70 ℃, the pressure is adjusted to 3.5Mpa, the rotating speed is adjusted to 36r/min, and the steps are repeated for 3-4 times; the method for pressing the pumpkin seed kernels comprises the steps of performing cold pressing by using an oil press, adjusting the temperature of a chamber of the oil press to 80 ℃, adjusting the pressure to 3.6Mpa, adjusting the rotating speed to 36r/min, and repeating the steps for 3-4 times.
6. The preparation method according to claim 3, wherein the water extraction in the step (3) is performed at an extraction temperature of 100 ℃, for an extraction time of 1 hour, and in a feed-liquid weight ratio of 1: 10-1: 20.
7. the method according to claim 3, wherein the ultrahigh pressure extraction in step (4) is performed under an extraction pressure of 100MPa, an extraction solution of 60vt% ethanol, and a liquid-solid weight ratio of 90: 1.
8. use of the health food composition of claim 1 or 2 for preparing a health food for improving male pollakiuria and urinary incontinence.
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