CN104998098B - It is a kind of to improve the solid beverage slept and preparation method - Google Patents
It is a kind of to improve the solid beverage slept and preparation method Download PDFInfo
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Abstract
The present invention provides a kind of solid beverage for improving sleep and preparation methods, its raw material is prepared with parts by weight, is made of 12 parts of radix rehmanniae recen, 12 parts of lily, 9 parts of asparagus fern, 20 parts of reed root, 5 parts of donkey-hide gelatin, 9 parts of wilsonii, 9 parts of fructus lycii, 9 parts of semen ziziphi spinosae, 9 parts of the seed of Oriental arborvitae, 9 parts of Rhizoma Atractylodis Macrocephalae, 9 parts of Poria cocos, 9 parts of Schisandra chinensis, 9 parts of mulberries, 5 parts of oyster, 9 parts of Radix Glycyrrhizae.Solve the problems, such as that treatment insomnia effect is undesirable in the prior art and instructions of taking does not follow Chinese medicine " slow to support " principle.
Description
Technical field
The invention belongs to pharmaceutical technology fields, are related to traditional Chinese medicine technology, especially a kind of solid beverage for improving sleep and system
Preparation Method.
Background technique
Insomnia refers to difficulty falling asleep, and intermediate keep alert while in bed early sleep poor quality, the sleeping time of easily waking up of sleeping significantly reduces, and has tight
The patient of weight also lies awake all night.Chronic insomnia easily causes vexed easy unrest, fatigue and weak, or even with headache, dreaminess, hidrosis, memory
Power decline, can also cause a series of clinical symptoms, and induce some psychosomatic diseases.
The harm of insomnia is it will be apparent that from the point of view of short-term effect, and sleep insufficiency will lead to apathetic, nothing tired out
Power, emotional lability is absent minded, and what is directly affected is work and study in second day.And from the point of long-term development, danger
Evil is even more huge and far-reaching: Most patients chronic insomnia, difficulty falling asleep, easily initiation anxiety disorder；Insomnia simultaneously is to induce certain
The possibility of kind of potential disease, such as vegetative dystonia are susceptible to suffer from that nervous function is hyperfunction, the hidrosis of the trick heart, palpitaition, the heart easily occurs
Rate is accelerated, is short of breath, contraction of muscle, trembling, urgent urination frequent micturition, chest have constriction, abdominal distension and rush down, pharyngeal obstruction sense, hidrosis,
The symptoms such as limbs fatigue, numbness；Insomnia will also result in great harm to the social nature of man, and due to chronic insomnia, people can become
Suspicious, sensitive, irritability and self-doubt, these certainly will influence the interpersonal relationships of its various aspects in family and work, thus
Generate feeling of lonely, sense of defeat.
Chinese medicine is particular about the process of one " slow to support " to the conditioning of human body, takes effect perhaps fast not as good as Western medicine, as long as but right
Disease, can remove old complaint, and temporary solution is effected a permanent cure again.Existing Chinese medicine is more with decoction or pill, mostly takes twice sooner or later, this
The eating method of right place can seriously affect treatment effect often because precipitate thing is to causing patient to forget to take medicine
Fruit.
There is also the prescriptions of traditional Chinese medicine of some treatment insomnias in the prior art, but mostly since compatibility inaccuracy or dose are uncomfortable
It closes, so that therapeutic effect is not obvious.
The TCM knowledge of insomnia: Chinese medicine think have a sleepless night reason it is very much, but " breakdown of the normal physiological coordination between the heart and the kidney " cause to have a sleepless night it is most commonly seen
Reason, " breakdown of the normal physiological coordination between the heart and the kidney " refer to a kind of state that the yin, yang, water, fiery relationship of the heart and kidney are lacked of proper care, it is big dirty to be related to the heart, kidney and liver three
Device, " dialectical record " are recorded: " heart kidney to be met at, and liver leads to its gas, the kidney heart to be met at, and liver leads its saliva, natural soul is fixed and mind is pacified ",
It can be seen that tranquilizing and allaying excitement need to coordinate heart, kidney and the big internal organs of liver three, the drug into the heart channel of Hang-Shaoyin, kidney channel and soothing the liver tonifying Qi should be selected.
The invention proposes a kind of solid beverages for improving sleep, prepare in strict accordance with Chinese medicine compatibility theory, and through excessive
Zoopery and clinical trial verifying are measured, has the effect of improving sleep well；In addition, it is beverage shape that the present invention, which takes mode,
Formula either in motion process, or during rest, can be taken at any time as drink, really reach in daily life
The effect of " slow to support " is arrived.
Summary of the invention
The present invention proposes the solid beverage and preparation method of a kind of improvement sleep, solves treatment insomnia effect in the prior art
The problem of fruit is undesirable and instructions of taking does not follow Chinese medicine " slow to support " principle.
A kind of solid beverage improving sleep, raw material is prepared with parts by weight, by 12 parts of radix rehmanniae recen, 12 parts of lily, asparagus fern 9
Part, 20 parts of reed root, 5 parts of donkey-hide gelatin, 9 parts of wilsonii, 9 parts of fructus lycii, 9 parts of semen ziziphi spinosae, 9 parts of the seed of Oriental arborvitae, 9 parts of Rhizoma Atractylodis Macrocephalae, 9 parts of Poria cocos,
9 parts of Schisandra chinensis, 9 parts of mulberries, 5 parts of oyster, 9 parts of Radix Glycyrrhizae compositions.
A kind of preparation method making solid beverage, includes the following steps:
Step 1: preparing raw material by above-mentioned parts by weight；
Step 2: Rhizoma Atractylodis Macrocephalae slice, control sheet 2~4mm of thickness are fried to yellowish-brown with honey toast wheat bran, are taken out, weed out honey wheat bran,
Obtain stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran medicine materical crude slice；Radix Glycyrrhizae slice, piece thickness are 2~4mm, are fried using bake with honey to yellow to buff, obtain sweet licorice piece；
Step 3: fructus lycii, mulberries, Schisandra chinensis are removed into impurity；Radix rehmanniae recen, asparagus fern, reed root, Poria cocos, wilsonii slice,
2~4mm of control sheet thickness obtains medicine materical crude slice；Semen ziziphi spinosae, the seed of Oriental arborvitae flatten to obtain medicine materical crude slice, and 80~100 mesh of oyster grinding and sieving obtains oyster
Powder；Donkey-hide gelatin crushed 200~300 meshes and obtain gelatin powder；
Step 4: by the radix rehmanniae recen handled well, asparagus fern, reed root, Poria cocos, fructus lycii, semen ziziphi spinosae, the seed of Oriental arborvitae, Rhizoma Atractylodis Macrocephalae, Poria cocos,
Schisandra chinensis, mulberries, oyster, licorice piece mix, feed intake, and extracting in water twice, is added 10 times of medicinal material inventory for the first time
Water, refluxing extraction 1.5h, second of addition, 8 times of amount water refluxing extraction 1h obtain extracting solution after merging filtering；
Step 5: after lily is pulverized plus 5 times of water impregnate two hours, and filtering obtains extracting solution；
Step 6: merging step 4,5 extracting solutions, be concentrated under reduced pressure into relative density 1.05~1.07, be added in step 3 and prepare
Gelatin powder, be spray-dried to obtain xeraphium after stirring and dissolving；
Step 7: dry granulation obtains granule after corrigent is added in step 6 gained xeraphium, packs to obtain the final product.Preferably,
The method that acanthopanax senticosus saponins are extracted in the step 7 is the extraction that flowed back by organic solvent.
Preferably, in the step 6 vacuum concentration method condition are as follows: pressure be 20~40KPa.
Preferably, spray drying condition is 160~180 DEG C of inlet air temperature, 80~95 DEG C of leaving air temp in the step 6.
Preferably, suspending agent is xanthan gum in the step 7；Flavouring agent is lemon extract, stevioside or sorbierite.
Glutinous rehmannia: property is sweet, trembles with fear.Return heart, liver and kidney channel.Radix rehmanniae recen clearing heat and cooling blood, yin-nourishing are promoted the production of body fluid.For the deep red polydipsia of pyreticosis tongue,
Yin asthenia generating intrinsic heat, hectic fever due to yin labor heat, Heat Diabetes are spitted blood, bleeding from five sense organs or subcutaneous tissue, spot dermexanthesis.
Lily: lily is the dry meat scale leaf of liliaceous plant tiger lily or Lilium tenuifolium.Lily is common Chinese herbal medicine,
It is that the Ministry of Public Health of China examines the first batch of dual-purpose of drug and food product passed through, nutritional ingredient mainly has protein, starch, polysaccharide and inorganic salts
Deng with good medical value.Chinese medicine thinks that lily sweet and slightly bitter taste is mild-natured.Enter the heart, lung channel.With Yin nourishing and lung moistening, clear away heart-fire
The function of tranquilizing the mind can be used for dry cough due to yin deficiency, overstrain cough hemoptysis, dysphoria palpitates with fear, insomnia and dreamful sleep, absent-minded equal diseases.It is traditional in Chinese medicine
It is commonly used in prescription as monarch drug in a prescription, such as lilii and Anemarrhenae Decoction (effect is antitoxic heart-soothing and sedative, moistening lung and clearing heat) in " gold doctor outline ",
Lilii and Rehmanniae Decoction (effect is profit nourishing heart lung, clearing heat and cooling blood).In the normal life of our mouths, lily is normal during our mouths are often lived
Dietotherapy article not only delicious, nutrition but also has had a good effect effect.
Asparagus fern: this product is the dried root of liliaceae plant asparagus.It autumn, the excavation of two season of winter, cleans, removes stem foot and palpus
Root is set and boils or steam in boiling water to the saturating heart, removes crust, cleaning, drying while hot.It is sweet, bitter, it trembles with fear.Return lung, kidney channel nourishing yin to moisten dryness, clearly
Lung fluid.For dryness of the lung dry cough, pertussis phlegm is glutinous, dry throat and mouth, dry constipation of intestines.
Reed root: this product is the fresh or dry rhizome of gramineae plant reed.Whole year can excavate, remove bud, fibrous root and
Membranaceous leaf, it is fresh or dried.It is sweet, it trembles with fear.It attaches to the lung and stomach meridians.Clearing heat and promoting fluid, relieving restlessness, preventing or arresting vomiting, diuresis.One medicine of reed root, clinically mainly
It, can clearing lung-heat heat and eliminating the phlegm apocenosis and clearing away the stomach-heat and the preventing or arresting vomiting that promotes the production of body fluid for following two aspects.Though its attribute is cold, sweet in flavor
Light and power can only be as the drug of auxiliary with clearing lung-heat stomach.But, it has an advantage, i.e. property is not grown greasy, promotes the production of body fluid evil without loving, all
Warm disease deep love defend, after gas or pyreticosis if any the syndrome of fluid deficiency and thirst, can all apply.
Donkey-hide gelatin: this product is that the skin of equid donkey is decocted, manufactured solid gum is concentrated.Sweet and neutral.Return lung, liver and kidney channel.
It enriches blood enriching yin, moisturizes, stop blooding.For blood deficiency chlorosis, dizziness palpitaition, impotence weakness, dysphoria and insomnia, endogenous deficient wind, xeropulmonary cough,
Overstrain cough hemoptysis, haematemesis hematuria, uterine bleeding of having blood in stool, vaginal bleeding during pregnancy.
Wilsonii: this product is drying, root and rhizome or the stem of Araliaceae wilsonii.Returns spleen, kidney, the heart channel of Hang-Shaoyin.QI invigorating is strong
Spleen tonifies the kidney to relieve mental strain.For the insufficiency of both the spleen and the kindey, asthenia, loss of appetite, soreness of waist and knee joint, insomnia and dreamful sleep.By main to wilsonii
The animal experiment study of extract wilsonii soap former times has though showing that it causes sleep effect without direct and significantly promotes sleep
Effect.
Fructus lycii: fructus lycii is sweet in flavor, it is mild-natured there is the effect of liver-kidney tonifying, cure mainly caused by liver and kidney deficiency, have a dizzy spell, visually not
Clearly, soreness and weakness of waist and knees, positive rash spermatorrhea, cough due to consumptive disease quench one's thirst and draw drink.Researches show that Long-term Oral wolfberry fruit powders can make the body of older population
Matter situation significantly improves, and the situation of vexed insomnia has significant improvement.
Semen ziziphi spinosae: semen ziziphi spinosae is the dry mature seed of rhamnaceae plant wild jujube, and " master is vexatious must not for Shennong's Herbal cloud
Sleep ", it is listed in top grade.Semen ziziphi spinosae nature and flavor are sweet, sour, flat, return liver, gallbladder, the heart channel of Hang-Shaoyin, have tonifying liver, calming heart, arrest sweating, effect of promoting the production of body fluid, more
It is more common tranquilizing soporific Chinese medicine for diseases such as restlessness of asrhenia type and insomnia, horrified to much dream, body void hidrosis, injury thirsts.Semen ziziphi spinosae is total
Saponin(e is the principle active component of semen ziziphi spinosae.Related zoopery discovery: semen ziziphi spinosae total saposins can reduce spontaneous activity in mice,
The central inhibitory action of yellow Jackets is cooperateed with, the central excitation effect of antagonism amphetamine has subliminal hypnosis sedation.
The seed of Oriental arborvitae: this product is the dry mature kernal of cupressaceae plant arbor-vitae.Autumn, two season of winter harvest mature seed, dry, remove
Kind of a skin is removed, kernel is collected.Sweet and neutral.Return heart, kidney, large intestine channel.Mental-tranquilization, hidroschesis, ease constipation.For dysphoria insomnia, palpitaition is seized with terror
It is sad, night sweat due to yin deficiency, dry constipation of intestines.
Rhizoma Atractylodis Macrocephalae: this product is the dry rhizome of compositae plant Rhizoma Atractylodis Macrocephalae.Bitter, sweet, warm.Returns spleen, stomach meridian.Strengthening the spleen and replenishing qi, eliminating dampness benefit
Water, hidroschesis, miscarriage prevention.For spleen eating less, abdominal distention diarrhea, phlegm retention anti-dazzle nervous, oedema, spontaneous perspiration, threatened abortion.Rhizoma Atractylodis Macrocephalae invigorating the spleen, and
Stomach, miscarriage prevention.For spleen eating less, diarrhea loose stool, threatened abortion.
Poria cocos: Poria cocos is the dry sclerotia that On Polyporaceae obtains Bodhisattva.It is sweet in flavor, light, it is mild-natured.Return heart, lung, spleen, kidney channel.Function
Energy clearing damp and promoting diuresis, invigorating the spleen, calming heart.For edema and little urine, phlegm retention anti-dazzle nervous, spleen eating less, just pool diarrhea, confused and worried, and palpitation with fear is lost
It sleeps.China eats Poria cocos, and oneself has bimillennial history, and Poria cocos is classified as " top grade " by Shennong's Herbal, and claiming it, " long term usage is pacified soul and supported
Mind, not hungry macrobiosis ".Poria cocos is one of Chinese medicine " four monarch's eight delicacies ", and the main chemical compositions of Poria cocos are pachymaran.Chen Chunxia etc. is ground
Study carefully the syngignoscism of pachymaran, the experimental results showed that, pachymaran has syngignoscism, pachymaran 100mg/ (kgd)
Continuous intraperitoneal administration 7d can enhance inhibition of the appropriate sodium of sulfuric acid to mouse maincenter, and mouse righting reflex loss duration is sulfuric acid
4.69 times of appropriate sodium control group, it is statistically significant (P < 0.05) with the appropriate sodium control group comparing difference of sulfuric acid.
Schisandra chinensis: this product is the dry mature fruit of magnoliaceae schisandra schisandra chinensis.The former practises title " Chinese Magnoliavine
Son ", the latter, which practises, claims " kadsura longepedunculata ".It picks, dry or is dried after steaming when the fruit matures in the fall, remove carpopodium and impurity.Acid,
Sweet, warm.Return lung, the heart, kidney channel.Astringency inducing, supplementing qi and promoting the production of body fluid, tonifying kidney and calming nerves.For long-last cough and virtual asthma, emission, enuresis frequent micturition,
Endless diarrhea, spontaneous perspiration, night sweat, injury thirst, feeble pulse of losing heart, Heat Diabetes, palpitation and insomnia.
Mulberries: also known as sorosis mulberries before more than 2,000 years have been the hired tonics of Chinese emperors.Because of the special life of mulberry tree
Long environment makes sorosis have the characteristics that spontaneous growth without any pollution so mulberries are otherwise known as " civil sage fruit ".It contains abundant
Activated protein, provitamin A, B1, B2, PP and C, amino acid, malic acid, succinic acid, tartaric acid, carrotene, minerals
It is that there are multiple efficacies to be described as " two by medical field for 4 times of grape that the nutrients such as calcium, phosphorus, iron, copper, zinc, which are 5~6 times of apple,
The best health fruit of eleventh century ".The function that body immunity has anti-aging beautifying face and moistering lotion can be significantly improved by often eating mulberries
Effect.Mulberries food but also can not only be used as medicine, and Chinese medicine thinks that mulberries are sweet in flavor, sour, cold nature.Enter the heart, liver and kidney channel.For strengthening by means of tonics, support
The good fruit of heart intelligence development.It is dry and other effects with Yin-nourishing and body fluid promoting of enriching blood ease constipation of quenching the thirst, cure mainly deficiency of YIN-blood and cause tinnitus of having a dizzy spell, the heart
Throb with fear, irritated insomnia, soreness and weakness of waist and knees, poliosis, quench one's thirst, the diseases such as dry, dry and hard excrement.
Oyster: this product is the shell of the long oyster of Ostreidae animal, ostrea talienwhanensis Crosse or Crassostrea rivularis.Whole year can harvest,
Fleshing is cleaned, is dried.It is salty, it is slightly cold.Return liver, gallbladder, kidney channel.It is transquilization with heavy material, checking exuberance of yang and tonifying yin, resolving hard lump.For insomnia of palpitating with fear,
Dizziness and tinnitus, scrofula subcutaneous nodule, abdominal mass lump in the abdomen.Calcined oyster shell astringency inducing.For spontaneous sweating, band is collapsed in spermatorrhea, acid regurgitation of having a stomachache.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, swollen fruit Radix or glycyrrhiza glabra.Sweet and neutral.Return heart, lung, spleen,
Stomach meridian.It invigorates the spleen and benefits qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.For weakness of the spleen and the stomach, fatigue and weakness, palpitaition
Shortness of breath, coughing with a lot of sputum, stomach duct and abdomen, four limbs contraction, carbuncle sore tumefacting virus alleviate drug toxicity, strong.
Chinese medicine compatibility theory:
Radix rehmanniae recen, lily nourishing Yin and clearing heat are reused in side, relieving restlessness of promoting the production of body fluid is monarch drug in a prescription.Asparagus fern, reed root principal drug assistance nourishing yin and clearing heat,
For ministerial drug.Donkey-hide gelatin, wilsonii, fructus lycii nourishing qi and blood；Semen ziziphi spinosae, the seed of Oriental arborvitae, Rhizoma Atractylodis Macrocephalae mental-tranquilization；Poria cocos restoring normal coordination between heart and kidney；Five
Taste QI invigorating holds back yin；Mulberries clear away heart-fire promoting blood circulation；Oyster tranquilizing mind takes into account its mark, is altogether adjutant.The sweet temperature QI invigorating of radix glycyrrhizae preparata, and can
Coordinating the drug actions of a prescription, to make medicine.Based on our enriching yin effects a permanent cure, supplemented by temporary solution tranquilizing the mind.
Specific embodiment
The following is a clear and complete description of the technical scheme in the embodiments of the invention, it is clear that described embodiment
Only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, the common skill in this field
Art personnel every other embodiment obtained without creative efforts belongs to the model that the present invention protects
It encloses.
The embodiment of the invention provides a kind of solid beverages for improving sleep, and raw material is prepared with parts by weight, by radix rehmanniae recen
12 parts, 12 parts of lily, 9 parts of asparagus fern, 20 parts of reed root, 5 parts of donkey-hide gelatin, 9 parts of wilsonii, 9 parts of fructus lycii, 9 parts of semen ziziphi spinosae, the seed of Oriental arborvitae 9
Part, 9 parts of Rhizoma Atractylodis Macrocephalae, 9 parts of Poria cocos, 9 parts of Schisandra chinensis, 9 parts of mulberries, 5 parts of oyster, 9 parts of Radix Glycyrrhizae compositions.
Glutinous rehmannia in we, lily are monarch drug in a prescription, also have lilii and Rehmanniae Decoction in ancient prescription, because of great profit nourishing heart lung, clearing heat and cooling blood, with
Have the function that purge the sthenic heart-fire；Semen ziziphi spinosae, the seed of Oriental arborvitae, Rhizoma Atractylodis Macrocephalae have the effect of mental-tranquilization, and in addition Rhizoma Atractylodis Macrocephalae can also cooperate and play
The effect of Li Shui avoids that the risk for generating water-sodium retention is used for a long time because of semen ziziphi spinosae；Wilsonii and Schisandra chinensis share great promotion
Sleep effect, currently, research wilsonii and Schisandra chinensis share after to the method for the sedative-hypnotic effect of mouse, using above threshold and threshold
Lower dose of sodium pentobarbitone causes mice sleep method, and the sedative-hypnotic effect that wilsonii and Schisandra chinensis are applied alone and are shared is compared
Research.Using the method that yellow Jackets induced mice is slept, studying wilsonii and Schisandra chinensis improves the dose-effect pass of sleep effect
System.As a result: wilsonii can extend sleeping time (P < 0.01), effective dose 16g/kg, and functioning window is 16~128g/
Kg, effect is the most significant when middle dosage is 64g/kg.Schisandra chinensis can shorten Sleep latency (P < 0.05), effective dose
For 3g/kg, functioning window is 3~12g/kg, and effect is the most significant when middle dosage is 12g/kg.Compared to the blank group, five are pierced
Add the dropping asleep latency (P < 0.01) that can significantly shorten yellow Jackets mouse with Schisandra chinensis combination group, and its sleep can be extended
Time (P < 0.01) can obviously increase the sleep rate (P < 0.05) of sub-threshold dose yellow Jackets mouse, and effect is better than single
With wilsonii group and five tastes subgroup is applied alone；Oyster has the effect of tranquilizing mind, but it is easy without taking for a long time as cinnabar
Generate the danger of mercury poisoning, it is solid for first choice of tranquilizing mind in our.
Preparation step is as follows:
Step 1: preparing raw material by above-mentioned parts by weight；
Step 2: Rhizoma Atractylodis Macrocephalae slice, control sheet 2~4mm of thickness are fried to yellowish-brown with honey toast wheat bran, are taken out, weed out honey wheat bran,
Obtain stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran medicine materical crude slice；Radix Glycyrrhizae slice, piece thickness are 2~4mm, are fried using bake with honey to yellow to buff, obtain sweet licorice piece；
Step 3: fructus lycii, mulberries, Schisandra chinensis are removed into impurity；Radix rehmanniae recen, asparagus fern, reed root, Poria cocos, wilsonii slice,
2~4mm of control sheet thickness obtains medicine materical crude slice；Semen ziziphi spinosae, the seed of Oriental arborvitae flatten to obtain medicine materical crude slice, and 80~100 mesh of oyster grinding and sieving obtains oyster
Powder；Donkey-hide gelatin crushed 200~300 meshes and obtain gelatin powder；
Step 4: by the radix rehmanniae recen handled well, asparagus fern, reed root, Poria cocos, fructus lycii, semen ziziphi spinosae, the seed of Oriental arborvitae, Rhizoma Atractylodis Macrocephalae, Poria cocos,
Schisandra chinensis, mulberries, oyster, licorice piece mix, feed intake, and extracting in water twice, is added 10 times of medicinal material inventory for the first time
Water, refluxing extraction 1.5h, second of addition, 8 times of amount water refluxing extraction 1h obtain extracting solution after merging filtering；
Step 5: after lily is pulverized plus 5 times of water impregnate two hours, and filtering obtains extracting solution；
Step 6: merging step 4,5 extracting solutions, be concentrated under reduced pressure into relative density 1.05~1.07, be added in step 3 and prepare
Gelatin powder, be spray-dried to obtain xeraphium after stirring and dissolving；
Step 7: dry granulation obtains granule after corrigent is added in step 6 gained xeraphium, packs to obtain the final product.
Preferably, in the step 6 vacuum concentration method condition are as follows: pressure be 20~40KPa.
Preferably, spray drying condition is 160~180 DEG C of inlet air temperature, 80~95 DEG C of leaving air temp in the step 6.
Preferably, suspending agent is xanthan gum in the step 7；Flavouring agent is lemon extract, stevioside or sorbierite.
Animal experiment
Experiment one: influence of the present invention to sub-threshold dose yellow Jackets mouse sleep time
Experimental material
Drug: through the foregoing embodiment and preparation method obtained solid particle, before test plus 100~200ml water be made into it is solid
Body beverage, for use.
Animal: Kunming mouse 40,20 ± 2g of weight, half male and half female is randomly divided into 2 groups, living environment and feeding patterns phase
Together, experimental group continuous gavage solid beverage 7 days, in 1h after the last administration, 40 mouse peritoneals inject 1% concentration yellow Jackets
50mg/kg, records each mouse sleep quality, and statistical procedures use Chi-square Test, the results are shown in Table 1.
Table 1:
It can be seen that solid beverage proposed by the present invention is small with sub-threshold dose yellow Jackets are dramatically increased by 1 data of table
The sleeping time of mouse.
Experiment 2: the present invention influences mice sleep quality
Experiment method:
Drug: through the foregoing embodiment and preparation method obtained solid particle, before test plus 100~200ml water be made into it is solid
Body beverage, for use.
Animal: Kunming mouse 40,20 ± 2g of weight, half male and half female is randomly divided into 2 groups, living environment and feeding patterns phase
Together, experimental group continuous gavage solid beverage 7 days carry out light during mice sleep and wake up with a start experiment, suddenly at interval of one hour
It turns on light one minute, observes mouse whether there is or not waking up with a start, as a result such as table 2.
Table 2:
It can be seen that solid beverage proposed by the present invention has the effect of improving mice sleep quality by 2 data of table.
Experiment three: whether there is or not influences on internal organs by the present invention
Experiment method
Will experiment one in Kunming mouse sacrificed by decapitation, coring, liver, spleen, lung, kidney, brain, adrenal gland, ovary, uterus, testis,
It is attached start, lymph node, fixed with 10% formalin solution, specimens paraffin embedding slices, with hematoxylin eosin stain, microscope observes tissue
The variation of form the results are shown in Table 3 and table 4.
Table 3:
Table 4:
It can be seen that compared with the control group by table 3 and 4 data of table, the microscopy results of each internal organs slice, each internal organs
Structure has no significant change, and shows that solid beverage proposed by the present invention is nontoxic.
Clinical trial:
Case 1:
State of an illness brief abstract: 45 years old Lee in Fengtai district of Beijing, male, over the past two years since operating pressure is big, difficulty falling asleep,
The intermediate easily awake and dreaminess of sleep, sleep quality is low, and vexed easy unrest, fatigue and weak, persistently takes hypnotic 1.5 years, during which,
Medical in various big hospital, hospital diagnosis is anxiety disorder, takes all kinds of Chinese and Western medicines and is showed no and is clearly better.It is taken daily May 7 in 2014
With the solid beverage proposed by the present invention for improving sleep, per per day 5 solid beverages of taking after mixing it with water, there is sleeper effect after three days changes
It is kind, it has clear improvement after seven days and memory take a favorable turn, fall asleep after taking January again without hell and high water, no sleep is not intermediate easily wakes up yet
Symptom, during which without other drugs are taken, life, food environment are with previous without big variation.
Case 2:
State of an illness brief abstract: 50 years old Mrs Liu in Hebei Shijiazhuang District, insomnia and dreamful sleep 5 years, not taking hypnotic cannot enter
It sleeps 3 years, angel, diet is poor, and figure is thin, frequent loose watery stool.Improvement proposed by the present invention is taken on January 15th, 2013
The solid beverage of sleep has prominent effect, appetite is compared with the past to have increased four per per day 7 solid beverages of taking after mixing it with water after seven days
/ mono-, stool forming；Sleeper effect improvement after half a month is taken, expression improves；It takes one month, weight is public compared with increasing by 1 before the moon
Jin, sleep no problem；It takes two months, weight body increases by 2.1 kilograms, and expression is normal, and stool restores normal, during which without taking its other medicine
Object, life, food environment are with previous without big variation.
Case 3:
State of an illness brief abstract: zhengding county Middle School Students, 18 years old, a nearly aypnia dreaminess, frequent diarrhea, dry
Without bitter taste, Chang Youwu reason is vexed, the light yellow tongue fur of tongue nature, small and wiry pulse.Improvement sleep proposed by the present invention is taken April 3 in 2015
Solid beverage, per per day 4 solid beverages of taking after mixing it with water, illness is clearly better two days later；Sleep quality restores after taking five,
The state of mind is good, no diarrhea；Body is without any discomfort after taking ten days, and tongue fur is normal, pulse is strong, during which without taking its other medicine
Object, life, food environment are with previous without big variation.
It can be shown by above-mentioned zoopery and clinical case, 1, the solid drink for improving sleep proposed by the invention
Material has the effect of improving sleep well especially have very high treatment to imitate the burnt symptom drawn by work and school work
Fruit；2, the present invention proposes that greatly facilitate patient takes mode in a manner of the taking of drink form, and realizes in " slow to support "
Medical knowledge opinion；3, the present invention proposes that solid beverage absolutely has no toxic side effect.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Within mind and principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.
Claims (4)
1. a kind of solid beverage for improving sleep, which is characterized in that raw material is prepared with parts by weight, by 12 parts of radix rehmanniae recen, lily
12 parts, 9 parts of asparagus fern, 20 parts of reed root, 5 parts of donkey-hide gelatin, 9 parts of wilsonii, 9 parts of fructus lycii, 9 parts of semen ziziphi spinosae, the seed of Oriental arborvitae 9
Part, 9 parts of Rhizoma Atractylodis Macrocephalae, 9 parts of Poria cocos, 9 parts of Schisandra chinensis, 9 parts of mulberries, 5 parts of oyster, 9 parts of Radix Glycyrrhizae compositions, preparation method include such as
Lower step:
Step 1: preparing raw material by above-mentioned parts by weight；
Step 2: Rhizoma Atractylodis Macrocephalae slice, control sheet 2~4mm of thickness are fried to yellowish-brown with honey toast wheat bran, are taken out, weed out honey wheat bran,
Obtain stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran medicine materical crude slice；Radix Glycyrrhizae slice, piece thickness are 2~4mm, are fried using bake with honey to yellow to buff, obtain sweet Radix Glycyrrhizae drink
Piece；
Step 3: fructus lycii, mulberries, Schisandra chinensis are removed into impurity；Radix rehmanniae recen, asparagus fern, reed root, Poria cocos, wilsonii slice, control
2~4mm of piece thickness obtains medicine materical crude slice；Semen ziziphi spinosae, the seed of Oriental arborvitae flatten to obtain medicine materical crude slice, and 80~100 mesh of oyster grinding and sieving obtains oyster
Powder；Donkey-hide gelatin crushed 200~300 meshes and obtain gelatin powder；
Step 4: by the radix rehmanniae recen handled well, asparagus fern, reed root, Poria cocos, fructus lycii, semen ziziphi spinosae, the seed of Oriental arborvitae, Rhizoma Atractylodis Macrocephalae, Poria cocos, five
Taste, mulberries, oyster, licorice piece mix, feed intake, and twice, 10 times of medicinal material inventory of water is added in extracting in water for the first time,
Refluxing extraction 1.5h, second of addition, 8 times of amount water refluxing extraction 1h, obtains extracting solution after merging filtering；
Step 5: after lily is pulverized plus 5 times of water impregnate two hours, and filtering obtains extracting solution；
Step 6: merging step 4,5 extracting solutions, be concentrated under reduced pressure into relative density 1.05~1.07, be added in step 3 and prepare
Gelatin powder, be spray-dried to obtain xeraphium after stirring and dissolving；
Step 7: dry granulation obtains granule after corrigent and suspending agent is added in step 6 gained xeraphium, packs to obtain the final product.
2. the solid beverage of a kind of improvement sleep according to claim 1, which is characterized in that depressurized in the step 6
The condition of concentration method are as follows: pressure is 20~40KPa.
3. the solid beverage of a kind of improvement sleep according to claim 1, which is characterized in that spraying in the step 6
Drying condition is 160~180 DEG C of inlet air temperature, 80~95 DEG C of leaving air temp.
4. a kind of solid beverage for improving sleep according to claim 1, which is characterized in that suspending agent in the step 7
For xanthan gum；Corrigent is lemon extract, stevioside or sorbierite.
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| CN106721841A (en) * | 2016-11-14 | 2017-05-31 | 天津金匮堂生物科技有限公司 | A kind of spina date seed solid beverage |
| CN106562167A (en) * | 2016-11-14 | 2017-04-19 | 天津金匮堂生物科技有限公司 | Solid beverage capable of promoting peaceful sleep and realizing weight reducing |
| CN106616175A (en) * | 2016-11-14 | 2017-05-10 | 天津金匮堂生物科技有限公司 | Sugar-free spina date seed solid beverage |
| CN106578813A (en) * | 2016-11-23 | 2017-04-26 | 天津金匮堂生物科技有限公司 | Formula and making method of spina date seed-containing solid beverage |
| CN106901120A (en) * | 2017-02-10 | 2017-06-30 | 天津金匮堂生物科技有限公司 | A kind of spina date seed solid beverage and preparation method thereof |
| CN109247554A (en) * | 2018-11-29 | 2019-01-22 | 东阿阿胶股份有限公司 | A kind of glue ginseng suanzaoren decoction and preparation method thereof |
| CN112568351A (en) * | 2020-02-05 | 2021-03-30 | 河北康平健康产业有限责任公司 | Spina date seed oligosaccharide solid beverage capable of treating insomnia and preparation method thereof |
| CN112314819A (en) * | 2020-10-30 | 2021-02-05 | 成都致耀医药科技有限公司 | Plant beverage for improving sleep and preparation method thereof |
| CN114190505A (en) * | 2021-12-15 | 2022-03-18 | 哈尔滨健领医疗科技有限公司 | Sleep-aiding solid beverage and preparation method thereof |
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Effective date of registration: 20190109 Address after: 050000 Warehouse No. 1, Provincial Academy of Agricultural Sciences, 598 Pingxi Road, Xinhua District, Shijiazhuang City, Hebei Province Patentee after: Hebei Kangping Health Industry Co., Ltd. Address before: 050000 Unit 602, Unit 3, 244 Xinhua Road, Qiaoxi District, Shijiazhuang City, Hebei Province Patentee before: Xie Xiaoliang |