CN106266138A - A kind of Chinese herbal and crude drugs preparations for preventing and treating industrialized culture left-eyed flounder Disease of skin fester - Google Patents
A kind of Chinese herbal and crude drugs preparations for preventing and treating industrialized culture left-eyed flounder Disease of skin fester Download PDFInfo
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- CN106266138A CN106266138A CN201610874523.8A CN201610874523A CN106266138A CN 106266138 A CN106266138 A CN 106266138A CN 201610874523 A CN201610874523 A CN 201610874523A CN 106266138 A CN106266138 A CN 106266138A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
Abstract
The invention discloses a kind of Chinese herbal and crude drugs preparations preventing and treating industrialized culture left-eyed flounder Disease of skin fester, it is prepared from by the Chinese crude drug of following weight portion: based on its parts by weight, Herba Artemisiae Scopariae 12 22 parts, Radix Bupleuri 16 20 parts, Radix Sophorae Flavescentis 12 18, Rhizoma Coptidis 8 12 parts, Cortex Moutan 12 18 parts, Rhizoma Polygoni Cuspidati 12 18 parts, Cortex Phellodendri 26 parts, Flos Lonicerae 8 11 parts, 26 parts of Radix Glycyrrhizae.By Chinese medicine reasonable formula, anti-inflammation, enhancing immunity effect the most notable, provide a kind of industrialized culture effective medicine of left-eyed flounder Disease of skin fester for culture fishery, have instant effect, curative effect really, no drug residue, feature without any side effects.The Chinese herbal and crude drugs preparations of the application present invention, can effectively control industrialized culture left-eyed flounder Disease of skin fester, reduces the M & M of Disease of skin fester.
Description
Technical field
The invention belongs to fishery practical technique field, specifically, be used for preventing and treating industrialized culture Flounder particularly to one
Chinese herbal and crude drugs preparations of sole class Disease of skin fester and preparation method thereof.
Background technology
The skin of industrialized culture left-eyed flounder includes epidermis and corium two-layer, and possibly together with a kind of special body of gland, energy
Secret out of substantial amounts of mucus, make skin be rich in mucosity, also can form effective physical protection barrier in fish surface simultaneously, protect
Protect the invasion and attack from pathogenic microorganism of the fish body.Industrialized culture left-eyed flounder once skin sustains damage, easily bacterial infection and
Produce death.Skin ulceration is industrialized culture left-eyed flounder dermatosis more typically, is typically due to parasite parasitism or fish
Body is infected the inflammation causing skin histology by mechanical injuries secondary bacterial, fungus etc., and affected area is the most downright bad, tissue loss
Forming defect, shallow defect is rotten to the corn, and deep is ulcer.The antibacterial of industrialized culture left-eyed flounder skin ulceration can be caused at present
Majority belongs to gram negative bacteria, mainly has pseudomonas, Aeromonas, tarda, vibrio etc..Industrialized culture Flounder Pleuronectidae
After Fish body surface festers, basis of microscopic observation, it is possible to find infect the necrosis of fish body surface meat fiber, dissolve, muscle fiber interstitial
The most broadening, there is edema, simultaneously also with the infiltration of the inflammatory cell such as lymphocyte and mononuclear cell.This disease is often
Concurrent with fish molds.In low temperature rainy season, position of festering is easy to long fish molds.Rotten afterbody continues development and then may result in bacillary
Septicemia, each internal organs all may occur in which pathological changes in various degree.
The Disease of skin fester of industrialized culture left-eyed flounder, the most all can occur, and treatment difficulty is big, for this disease
Preventing and treating must adhere to the principle of " put prevention first, anti-overweight control ".If fish body surface festers, treat such disease and not only want
Killing the pathogenic bacterium in water body, more important point is to kill the antibacterial at skin ulceration, takes antibacterials purged body orally simultaneously
Interior pathogenic bacterium.
Present stage many employings western medicine antibiotics is treated, although aquatic medicine controls relatively strict, but western medicine antibiotics is indiscriminate
The most extremely serious by situation so that the treatment difficulty of industrialized culture left-eyed flounder strengthens, and drug residue problem is more and more heavier, gives
Food-safety problem causes serious threat.China's natural resources of Chinese medicinal materials enriches, and by rationally screening Chinese medicine and prescription, makees
First-selected for preventing and treating industrialized culture left-eyed flounder Disease of skin fester, will have very important production practices meaning.
Chinese herbal medicine belongs to natural drug, in application and the research of China, has accumulated rich experience.Utilize Chinese herbal medicine
Preventing and treating industrialized culture left-eyed flounder Disease of skin fester, increasingly by attention and the favor of people, is increasingly widely accepted, is
Inseparable with the mechanism of action of its uniqueness, model of action and advantage, to put it briefly, herbal control disease has adjustment and makees
With, strengthening vital QI to eliminate pathogenic factors, have no drug resistance and feature that the other medicines such as nuisanceless are incomparable and advantage, effective, and do not deposit
In the residue problem of antibiotic medicine, highly beneficial to the animal husbandry products export of China.It addition, Chinese herbal medicine also has price just
Preferably, wide material sources, the advantage such as easy to use, is one of the developing direction of fish medicine from now on.
Summary of the invention
It is an object of the invention to provide a kind of Chinese herbal medicine for preventing and treating industrialized culture left-eyed flounder Disease of skin fester
Preparation.
The object of the present invention is achieved like this:
A kind of Chinese herbal and crude drugs preparations for preventing and treating industrialized culture left-eyed flounder Disease of skin fester, by following weight portion
Medical material is prepared from: Herba Artemisiae Scopariae 16-22 part, Radix Bupleuri 16-20 part, Radix Sophorae Flavescentis 12-18, Rhizoma Coptidis 8-12 part, Cortex Moutan 12-18 part, Rhizoma Polygoni Cuspidati
12-18 part, Cortex Phellodendri 2-6 part, Flos Lonicerae 8-11 part, Radix Glycyrrhizae 2-6 part.
Preferably, the described Chinese herbal and crude drugs preparations for preventing and treating industrialized culture left-eyed flounder Disease of skin fester, by as follows
The Chinese crude drug of weight portion is prepared from: Herba Artemisiae Scopariae 18 parts, Radix Bupleuri 18 parts, Radix Sophorae Flavescentis 16, Rhizoma Coptidis 10 parts, Cortex Moutan 16 parts, Rhizoma Polygoni Cuspidati 14 parts,
Cortex Phellodendri 4 parts, Flos Lonicerae 9 parts, 4 parts of Radix Glycyrrhizae.
It is further preferred that the described Chinese herbal and crude drugs preparations being used for preventing and treating industrialized culture left-eyed flounder Disease of skin fester is
Granule.
By the preparation method of the Chinese herbal and crude drugs preparations that above-mentioned each Chinese crude drug preparation cost is invented, comprise the steps:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh the above-mentioned Chinese crude drug cleaned up by recipe quantity, pulverize, standby；
2) decocting: boiling, first decocts every tank adds water 8 times into medical material total amount, keeps 2 hours, carry after ebuillition of heated
Take liquid and filter entrance settling tank through 200 mesh filters；Second decocts the water heating extraction adding medical material amount 6 times, protects boiling 1.5 little
Time, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitation: in settling tank, extracting solution precipitates 12 hours, extraction supernatant filters to triple effect steaming through 200 mesh filters
Sending out in device, precipitate presses offal treatment；
4) concentrate: when supernatant be concentrated in triple effect evaporator relative density be 1.05～1.10 (40 DEG C of mensuration) time,
By dilute clear paste in 200 mesh filters filter suction vacuum decompressioning and concentrating tank, addition ethanol, to alcohol content 60% (v/v), is placed,
Filter；Concentrate and mix and go out cream when being 1.10～1.22 (90 DEG C of mensuration) to relative density, to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01MPa, temperature: 78～82 DEG C, drying time 12～18 hours；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, puts into clear paste powder in trough type mixing machine with starch, stirs 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, pelletizes with 12 mesh stainless steel sifts, and 60～70 DEG C are dried 2 hours, take out, cool and i.e. obtain described granule
Agent.
The consumption of above-mentioned preventing and treating industrialized culture left-eyed flounder Disease of skin fester Chinese medicine granules is by 50-80g/100kg
The ratio of body weight mixes pharmaceutical chemistry, allows industrialized culture left-eyed flounder be administered orally, and being used in conjunction 5-7 days is a course for the treatment of.
The present inventor prevents and treats industrialized culture left-eyed flounder Disease of skin fester with Chinese herbal and crude drugs preparations, from our experimental result
Seeing, the Chinese herbal and crude drugs preparations of the application present invention can effectively control industrialized culture left-eyed flounder Disease of skin fester, reduces batch production and supports
Grow the M & M of left-eyed flounder Disease of skin fester, but also do not produce drug resistance.The present invention is reasonable by Chinese medicine
Prescription, anti-inflammation, enhancing immunity effect extremely notable, provide a kind of industrialized culture Flounder sole for culture fishery
Effective medicine of class Disease of skin fester, have instant effect, curative effect really, no drug residue, feature without any side effects；Its
Preparation method is simple, is suitable for the needs that large-scale industrial produces.
Detailed description of the invention
The present invention is further illustrated below by embodiment.Embodiments of the invention are only used for illustrating the present invention, and
It not limitation of the present invention, under the concept thereof of the present invention, the simple modifications of preparation method of the present invention is broadly fallen into the present invention
Claimed scope.Below in conjunction with specific embodiment, technical scheme of the present invention is further described.
Embodiment 1
A kind of Chinese medicine granules preventing and treating industrialized culture left-eyed flounder Disease of skin fester, by Herba Artemisiae Scopariae, Radix Bupleuri, Radix Sophorae Flavescentis, Huang
Company, Cortex Moutan, Rhizoma Polygoni Cuspidati, Cortex Phellodendri, Flos Lonicerae, Radix Glycyrrhizae composition, wherein, Herba Artemisiae Scopariae 18kg, Radix Bupleuri 18kg, Radix Sophorae Flavescentis 16kg, Rhizoma Coptidis 10kg,
Cortex Moutan 16kg, Rhizoma Polygoni Cuspidati 14kg, Cortex Phellodendri 4kg, Flos Lonicerae 9kg, Radix Glycyrrhizae 4kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating industrialized culture left-eyed flounder Disease of skin fester, specifically prepares step
Rapid as follows:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh clear Herba Artemisiae Scopariae 18kg, Radix Bupleuri 18kg, Radix Sophorae Flavescentis 16kg, Rhizoma Coptidis 10kg, Cortex Moutan 16kg, Rhizoma Polygoni Cuspidati 14kg,
Cortex Phellodendri 4kg, Flos Lonicerae 9kg, Radix Glycyrrhizae 4kg are raw material, wash clean Chinese crude drug, pulverize, standby；
2) decocting: boiling, first decocts every tank adds water 8 times into medical material total amount, keeps 2 hours, carry after ebuillition of heated
Take liquid and filter entrance settling tank through 200 mesh filters；Second decocts the water heating extraction adding medical material amount 6 times, protects boiling 1.5 little
Time, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitation: in settling tank, extracting solution precipitates 12 hours, extraction supernatant filters to triple effect steaming through 200 mesh filters
Sending out in device, precipitate presses offal treatment；
4) concentrate: when supernatant be concentrated in triple effect evaporator relative density be 1.05～1.10 (40 DEG C of mensuration) time,
By dilute clear paste in 200 mesh filters filter suction vacuum decompressioning and concentrating tank, addition ethanol, to alcohol content 60% (v/v), is placed,
Filter；Concentrate and mix and go out cream when being 1.10～1.22 (90 DEG C of mensuration) to relative density, to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01MPa, temperature: 78～82 DEG C, drying time 12～18 hours；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, puts into clear paste powder in trough type mixing machine with starch, stirs 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, pelletizes with 12 mesh stainless steel sifts, and 60～70 DEG C are dried 2 hours, take out, cool and i.e. obtain described granule
Agent.
Embodiment 2
A kind of Chinese medicine granules preventing and treating industrialized culture left-eyed flounder Disease of skin fester, by Herba Artemisiae Scopariae, Radix Bupleuri, Radix Sophorae Flavescentis, Huang
Company, Cortex Moutan, Rhizoma Polygoni Cuspidati, Cortex Phellodendri, Flos Lonicerae, Radix Glycyrrhizae composition, wherein, Herba Artemisiae Scopariae 19kg, Radix Bupleuri 17kg, Radix Sophorae Flavescentis 15kg, Rhizoma Coptidis 9kg,
Cortex Moutan 14kg, Rhizoma Polygoni Cuspidati 13kg, Cortex Phellodendri 3kg, Flos Lonicerae 10kg, Radix Glycyrrhizae 5kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating industrialized culture left-eyed flounder Disease of skin fester, specifically prepares step
Rapid as follows:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh Herba Artemisiae Scopariae 19kg, Radix Bupleuri 17kg, Radix Sophorae Flavescentis 15kg, Rhizoma Coptidis 9kg, Cortex Moutan 14kg, Rhizoma Polygoni Cuspidati 13kg, Huang
Cypress 3kg, Flos Lonicerae 10kg, Radix Glycyrrhizae 5kg are raw material, wash clean Chinese crude drug, pulverize, standby；
2) decocting: boiling, first decocts every tank adds water 8 times into medical material total amount, keeps 2 hours, carry after ebuillition of heated
Take liquid and filter entrance settling tank through 200 mesh filters；Second decocts the water heating extraction adding medical material amount 6 times, protects boiling 1.5 little
Time, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitation: in settling tank, extracting solution precipitates 12 hours, extraction supernatant filters to triple effect steaming through 200 mesh filters
Sending out in device, precipitate presses offal treatment；
4) concentrate: when supernatant be concentrated in triple effect evaporator relative density be 1.05～1.10 (40 DEG C of mensuration) time,
By dilute clear paste in 200 mesh filters filter suction vacuum decompressioning and concentrating tank, addition ethanol, to alcohol content 60% (v/v), is placed,
Filter；Concentrate and mix and go out cream when being 1.10～1.22 (90 DEG C of mensuration) to relative density, to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01MPa, temperature: 78～82 DEG C, drying time 12～18 hours；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, puts into clear paste powder in trough type mixing machine with starch, stirs 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, pelletizes with 12 mesh stainless steel sifts, and 60～70 DEG C are dried 2 hours, take out, cool and i.e. obtain described granule
Agent.
Embodiment 3
A kind of Chinese medicine granules preventing and treating industrialized culture left-eyed flounder Disease of skin fester, by Herba Artemisiae Scopariae, Radix Bupleuri, Radix Sophorae Flavescentis, Huang
Company, Cortex Moutan, Rhizoma Polygoni Cuspidati, Cortex Phellodendri, Flos Lonicerae, Radix Glycyrrhizae composition, wherein, Herba Artemisiae Scopariae 20kg, Radix Bupleuri 20kg, Radix Sophorae Flavescentis 18kg, Rhizoma Coptidis 12kg,
Cortex Moutan 18kg, Rhizoma Polygoni Cuspidati 18kg, Cortex Phellodendri 6kg, Flos Lonicerae 11kg, Radix Glycyrrhizae 6kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating industrialized culture left-eyed flounder Disease of skin fester, specifically prepares step
Rapid as follows:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh Herba Artemisiae Scopariae 19kg, Radix Bupleuri 17kg, Radix Sophorae Flavescentis 15kg, Rhizoma Coptidis 9kg, Cortex Moutan 14kg, Rhizoma Polygoni Cuspidati 13kg, Huang
Cypress 3kg, Flos Lonicerae 10kg, Radix Glycyrrhizae 5kg are raw material, wash clean Chinese crude drug, pulverize, standby；
2) decocting: boiling, first decocts every tank adds water 8 times into medical material total amount, keeps 2 hours, carry after ebuillition of heated
Take liquid and filter entrance settling tank through 200 mesh filters；Second decocts the water heating extraction adding medical material amount 6 times, protects boiling 1.5 little
Time, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitation: in settling tank, extracting solution precipitates 12 hours, extraction supernatant filters to triple effect steaming through 200 mesh filters
Sending out in device, precipitate presses offal treatment；
4) concentrate: when supernatant be concentrated in triple effect evaporator relative density be 1.05～1.10 (40 DEG C of mensuration) time,
By dilute clear paste in 200 mesh filters filter suction vacuum decompressioning and concentrating tank, addition ethanol, to alcohol content 60% (v/v), is placed,
Filter；Concentrate and mix and go out cream when being 1.10～1.22 (90 DEG C of mensuration) to relative density, to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01MPa, temperature: 78～82 DEG C, drying time 12～18 hours；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, puts into clear paste powder in trough type mixing machine with starch, stirs 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, pelletizes with 12 mesh stainless steel sifts, and 60～70 DEG C are dried 2 hours, take out, cool and i.e. obtain described granule
Agent.
Embodiment 4 clinical trial
The consumption of the Chinese medicine granules of above-mentioned preventing and treating industrialized culture left-eyed flounder Disease of skin fester is by 60g/100kg body
The ratio of weight mixes pharmaceutical chemistry, and oral, being used in conjunction 5 days is a course for the treatment of.Reach to treat the purpose of disease by intestinal absorption after Kou Fu.
On June 28th, 2013, the batch production that area, Rongcheng, Shandong Province certain industrialized culture left-eyed flounder raiser raises is supported
Grow left-eyed flounder morbidity, clinical symptoms: ill industrialized culture left-eyed flounder fish tail shank, trunk or skin of head is burst
Rotten, necrosis comes off, and severe patient festers and is deep into Musclar layer, and the sick fish kiss end having festers.It is typical case's ulcer disease after diagnosing.Then with this
After Chinese medicine granules treatment, medication 2 days described in inventive embodiments 2, the state of an illness is clearly better, the change of health color substantially, mortality rate
Reducing by sky, after 5 days, mortality rate is 0, is almost recovered.
Inventor prevents and treats industrialized culture left-eyed flounder Disease of skin fester with Chinese herbal and crude drugs preparations, from our experimental result
See, no matter be prevention, or treatment, evident in efficacy, but also do not produce drug resistance, promoting through test of many times and little area should
With, achieve good effect, make fishing ground economic benefit significantly improve.
Claims (3)
1. the Chinese herbal and crude drugs preparations being used for preventing and treating industrialized culture left-eyed flounder Disease of skin fester, it is characterised in that: by as follows
The Chinese crude drug of weight portion is prepared from: Herba Artemisiae Scopariae 12-22 part, Radix Bupleuri 16-20 part, Radix Sophorae Flavescentis 12-18, Rhizoma Coptidis 8-12 part, Cortex Moutan 12-
18 parts, Rhizoma Polygoni Cuspidati 12-18 part, Cortex Phellodendri 2-6 part, Flos Lonicerae 8-11 part, Radix Glycyrrhizae 2-6 part.
Chinese herbal and crude drugs preparations for preventing and treating industrialized culture left-eyed flounder Disease of skin fester the most according to claim 1, its
It is characterised by: be prepared from by the Chinese crude drug of following weight portion: Herba Artemisiae Scopariae 18 parts, Radix Bupleuri 18 parts, Radix Sophorae Flavescentis 16, Rhizoma Coptidis 10 parts, Paeonia suffruticosa
Skin 16 parts, Rhizoma Polygoni Cuspidati 14 parts, Cortex Phellodendri 4 parts, Flos Lonicerae 9 parts, 4 parts of Radix Glycyrrhizae.
Chinese herbal and crude drugs preparations for preventing and treating industrialized culture left-eyed flounder Disease of skin fester the most according to claim 1 and 2,
It is characterized in that: it is granule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610874523.8A CN106266138A (en) | 2016-09-30 | 2016-09-30 | A kind of Chinese herbal and crude drugs preparations for preventing and treating industrialized culture left-eyed flounder Disease of skin fester |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610874523.8A CN106266138A (en) | 2016-09-30 | 2016-09-30 | A kind of Chinese herbal and crude drugs preparations for preventing and treating industrialized culture left-eyed flounder Disease of skin fester |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114949083A (en) * | 2022-06-16 | 2022-08-30 | 河北科技师范学院 | Chinese herbal medicine composition for preventing and treating bacterial diseases of flounder |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114949083A (en) * | 2022-06-16 | 2022-08-30 | 河北科技师范学院 | Chinese herbal medicine composition for preventing and treating bacterial diseases of flounder |
| CN114949083B (en) * | 2022-06-16 | 2023-08-04 | 秦皇岛粮丰海洋生态科技开发股份有限公司 | Chinese herbal medicine composition for preventing and treating bacterial diseases of flounder |
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