CN106266139A - A kind of Chinese herbal and crude drugs preparations for preventing and treating industrialized culture red fin east Disease of skin fester - Google Patents
A kind of Chinese herbal and crude drugs preparations for preventing and treating industrialized culture red fin east Disease of skin fester Download PDFInfo
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- CN106266139A CN106266139A CN201610874613.7A CN201610874613A CN106266139A CN 106266139 A CN106266139 A CN 106266139A CN 201610874613 A CN201610874613 A CN 201610874613A CN 106266139 A CN106266139 A CN 106266139A
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- 229940079593 drug Drugs 0.000 title claims abstract description 28
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/233—Bupleurum
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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Abstract
The invention discloses a kind of Chinese herbal and crude drugs preparations preventing and treating industrialized culture red fin east Disease of skin fester, it is prepared from by the Chinese crude drug of following weight portion: based on its parts by weight, Herba Artemisiae Scopariae 12 22 parts, Radix Bupleuri 16 20 parts, Radix Sophorae Flavescentis 12 18, Radix Isatidis 8 12 parts, Cortex Moutan 12 18 parts, Rhizoma Polygoni Cuspidati 12 18 parts, Cortex Phellodendri 26 parts, Flos Lonicerae 8 11 parts, Galla Chinensis 26 parts.By Chinese medicine reasonable formula, anti-inflammation, enhancing immunity effect the most notable, provide a kind of industrialized culture red fin east effective medicine of Disease of skin fester for culture fishery, have instant effect, curative effect really, no drug residue, feature without any side effects.The Chinese herbal and crude drugs preparations of the application present invention, can effectively control industrialized culture red fin east Disease of skin fester, reduces the M & M of Disease of skin fester.
Description
Technical field
The invention belongs to fishery practical technique field, specifically, be used for preventing and treating industrialized culture particularly to one red
Chinese herbal and crude drugs preparations of fin east Disease of skin fester and preparation method thereof.
Background technology
The skin in industrialized culture red fin east includes epidermis and corium two-layer, and possibly together with a kind of special body of gland,
Substantial amounts of mucus can be secreted out of, make skin be rich in mucosity, also can form effective physical protection barrier in fish surface simultaneously,
Protection fish body is from the invasion and attack of pathogenic microorganism.Industrialized culture red fin east, once skin sustains damage, is easily infected thin
Bacterium and produce death.Skin ulceration is industrialized culture red fin east dermatosis more typically, is typically due to parasite and posts
Raw or fish body is infected the inflammation causing skin histology by mechanical injuries secondary bacterial, fungus etc., and affected area is the most downright bad, group
Knitting the formation defect that comes off, shallow defect is rotten to the corn, and deep is ulcer.Industrialized culture red fin east skin can be caused at present to burst
Rotten antibacterial majority belongs to gram negative bacteria, mainly has pseudomonas, Aeromonas, tarda, vibrio etc..Batch production
Cultivate after red fin east body surface festers, basis of microscopic observation, it is possible to find infect that fish body surface meat fiber is downright bad, dissolve,
Muscle fiber interstitial is the most broadening, and edema occurs, simultaneously also with the leaching of the inflammatory cell such as lymphocyte and mononuclear cell
Profit.This disease is often concurrent with fish molds.In low temperature rainy season, position of festering is easy to long fish molds.Rotten afterbody continues development then
May result in bacterial septicemia, each internal organs all may occur in which pathological changes in various degree.
The Disease of skin fester in industrialized culture red fin east, the most all can occur, and treatment difficulty is big, for this
Sick preventing and treating must adhere to the principle of " putting prevention first, anti-overweighting is controlled ".If fish body surface festers, treat such disease not only
Pathogenic bacterium in water body to be killed, more important point is to kill the antibacterial at skin ulceration, takes antibacterials simultaneously orally and removes
Internal pathogenic bacterium.
Present stage many employings western medicine antibiotics is treated, although aquatic medicine controls relatively strict, but western medicine antibiotics is indiscriminate
It is the most extremely serious by situation so that the treatment difficulty in industrialized culture red fin east strengthens, and drug residue problem is more and more heavier,
Serious threat is caused to food-safety problem.China's natural resources of Chinese medicinal materials enriches, by Chinese medicine is rationally screened and prescription,
First-selected as preventing and treating industrialized culture red fin east Disease of skin fester, will have very important production practices meaning.
Chinese herbal medicine belongs to natural drug, in application and the research of China, has accumulated rich experience.Utilize Chinese herbal medicine
Preventing and treating industrialized culture red fin east Disease of skin fester, increasingly by attention and the favor of people, is increasingly widely accepted,
Being that the mechanism of action with its uniqueness, model of action and advantage are inseparable, put it briefly, herbal control disease has adjustment and makees
With, strengthening vital QI to eliminate pathogenic factors, have no drug resistance and feature that the other medicines such as nuisanceless are incomparable and advantage, effective, and do not deposit
In the residue problem of antibiotic medicine, highly beneficial to the animal husbandry products export of China.It addition, Chinese herbal medicine also has price just
Preferably, wide material sources, the advantage such as easy to use, is one of the developing direction of fish medicine from now on.
Summary of the invention
It is an object of the invention to provide a kind of medium-height grass for preventing and treating industrialized culture red fin east Disease of skin fester
Medicine preparation.
The object of the present invention is achieved like this:
A kind of Chinese herbal and crude drugs preparations for preventing and treating industrialized culture red fin east Disease of skin fester, by following weight portion
Chinese crude drug is prepared from: Herba Artemisiae Scopariae 16-22 part, Radix Bupleuri 16-20 part, Radix Sophorae Flavescentis 12-18, Radix Isatidis 8-12 part, Cortex Moutan 12-18 part,
Rhizoma Polygoni Cuspidati 12-18 part, Cortex Phellodendri 2-6 part, Flos Lonicerae 8-11 part, Galla Chinensis 2-6 part.
Preferably, the described Chinese herbal and crude drugs preparations for preventing and treating industrialized culture red fin east Disease of skin fester, by such as
The Chinese crude drug of lower weight portion is prepared from: Herba Artemisiae Scopariae 18 parts, Radix Bupleuri 18 parts, Radix Sophorae Flavescentis 16, Radix Isatidis 10 parts, Cortex Moutan 16 parts, Rhizoma Polygoni Cuspidati
14 parts, Cortex Phellodendri 4 parts, Flos Lonicerae 9 parts, Galla Chinensis 4 parts.
It is further preferred that the described Chinese herbal and crude drugs preparations for preventing and treating industrialized culture red fin east Disease of skin fester
It it is granule.
By the preparation method of the Chinese herbal and crude drugs preparations that above-mentioned each Chinese crude drug preparation cost is invented, comprise the steps:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh the above-mentioned Chinese crude drug cleaned up by recipe quantity, pulverize, standby；
2) decocting: boiling, first decocts every tank adds water 8 times into medical material total amount, keeps 2 hours, carry after ebuillition of heated
Take liquid and filter entrance settling tank through 200 mesh filters；Second decocts the water heating extraction adding medical material amount 6 times, protects boiling 1.5 little
Time, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitation: in settling tank, extracting solution precipitates 12 hours, extraction supernatant filters to triple effect steaming through 200 mesh filters
Sending out in device, precipitate presses offal treatment；
4) concentrate: when supernatant be concentrated in triple effect evaporator relative density be 1.05～1.10 (40 DEG C of mensuration) time,
By dilute clear paste in 200 mesh filters filter suction vacuum decompressioning and concentrating tank, addition ethanol, to alcohol content 60% (v/v), is placed,
Filter；Concentrate and mix and go out cream when being 1.10～1.22 (90 DEG C of mensuration) to relative density, to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01MPa, temperature: 78～82 DEG C, drying time 12～18 hours；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, puts into clear paste powder in trough type mixing machine with starch, stirs 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, pelletizes with 12 mesh stainless steel sifts, and 60～70 DEG C are dried 2 hours, take out, cool and i.e. obtain described granule
Agent.
The consumption of above-mentioned preventing and treating industrialized culture red fin east Disease of skin fester Chinese medicine granules is by 50-80g/
The ratio of 100kg body weight mixes pharmaceutical chemistry, allows industrialized culture red fin east be administered orally, and being used in conjunction 5-7 days is a course for the treatment of.
The present inventor, with Chinese herbal and crude drugs preparations preventing and treating industrialized culture red fin east Disease of skin fester, ties from our experiment
Fruit sees, the Chinese herbal and crude drugs preparations of the application present invention can effectively control industrialized culture red fin east Disease of skin fester, reduces factory
Change the M & M cultivating red fin east Disease of skin fester, but also do not produce drug resistance.The present invention is by tradition
Medicine reasonable formula, anti-inflammation, enhancing immunity effect extremely notable, provide a kind of industrialized culture for culture fishery
Effective medicine of red fin east Disease of skin fester, have instant effect, curative effect really, no drug residue, without any side effects
Feature；Its preparation method is simple, is suitable for the needs that large-scale industrial produces.
Detailed description of the invention
The present invention is further illustrated below by embodiment.Embodiments of the invention are only used for illustrating the present invention, and
It not limitation of the present invention, under the concept thereof of the present invention, the simple modifications of preparation method of the present invention is broadly fallen into the present invention
Claimed scope.Below in conjunction with specific embodiment, technical scheme of the present invention is further described.
Embodiment 1
A kind of Chinese medicine granules preventing and treating industrialized culture red fin east Disease of skin fester, by Herba Artemisiae Scopariae, Radix Bupleuri, Radix Sophorae Flavescentis,
Radix Isatidis, Cortex Moutan, Rhizoma Polygoni Cuspidati, Cortex Phellodendri, Flos Lonicerae, Galla Chinensis composition, wherein, Herba Artemisiae Scopariae 18kg, Radix Bupleuri 18kg, Radix Sophorae Flavescentis 16kg, plate
Blue root 10kg, Cortex Moutan 16kg, Rhizoma Polygoni Cuspidati 14kg, Cortex Phellodendri 4kg, Flos Lonicerae 9kg, Galla Chinensis 4kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating industrialized culture red fin east Disease of skin fester, specifically prepares
Step is as follows:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh clear Herba Artemisiae Scopariae 18kg, Radix Bupleuri 18kg, Radix Sophorae Flavescentis 16kg, Radix Isatidis 10kg, Cortex Moutan 16kg, Rhizoma Polygoni Cuspidati
14kg, Cortex Phellodendri 4kg, Flos Lonicerae 9kg, Galla Chinensis 4kg are raw material, wash clean Chinese crude drug, pulverize, standby；
2) decocting: boiling, first decocts every tank adds water 8 times into medical material total amount, keeps 2 hours, carry after ebuillition of heated
Take liquid and filter entrance settling tank through 200 mesh filters；Second decocts the water heating extraction adding medical material amount 6 times, protects boiling 1.5 little
Time, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitation: in settling tank, extracting solution precipitates 12 hours, extraction supernatant filters to triple effect steaming through 200 mesh filters
Sending out in device, precipitate presses offal treatment；
4) concentrate: when supernatant be concentrated in triple effect evaporator relative density be 1.05～1.10 (40 DEG C of mensuration) time,
By dilute clear paste in 200 mesh filters filter suction vacuum decompressioning and concentrating tank, addition ethanol, to alcohol content 60% (v/v), is placed,
Filter；Concentrate and mix and go out cream when being 1.10～1.22 (90 DEG C of mensuration) to relative density, to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01MPa, temperature: 78～82 DEG C, drying time 12～18 hours；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, puts into clear paste powder in trough type mixing machine with starch, stirs 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, pelletizes with 12 mesh stainless steel sifts, and 60～70 DEG C are dried 2 hours, take out, cool and i.e. obtain described granule
Agent.
Embodiment 2
A kind of Chinese medicine granules preventing and treating industrialized culture red fin east Disease of skin fester, by Herba Artemisiae Scopariae, Radix Bupleuri, Radix Sophorae Flavescentis,
Radix Isatidis, Cortex Moutan, Rhizoma Polygoni Cuspidati, Cortex Phellodendri, Flos Lonicerae, Galla Chinensis composition, wherein, Herba Artemisiae Scopariae 19kg, Radix Bupleuri 17kg, Radix Sophorae Flavescentis 15kg, plate
Blue root 9kg, Cortex Moutan 14kg, Rhizoma Polygoni Cuspidati 13kg, Cortex Phellodendri 3kg, Flos Lonicerae 10kg, Galla Chinensis 5kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating industrialized culture red fin east Disease of skin fester, specifically prepares
Step is as follows:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh Herba Artemisiae Scopariae 19kg, Radix Bupleuri 17kg, Radix Sophorae Flavescentis 15kg, Radix Isatidis 9kg, Cortex Moutan 14kg, Rhizoma Polygoni Cuspidati 13kg,
Cortex Phellodendri 3kg, Flos Lonicerae 10kg, Galla Chinensis 5kg are raw material, wash clean Chinese crude drug, pulverize, standby；
2) decocting: boiling, first decocts every tank adds water 8 times into medical material total amount, keeps 2 hours, carry after ebuillition of heated
Take liquid and filter entrance settling tank through 200 mesh filters；Second decocts the water heating extraction adding medical material amount 6 times, protects boiling 1.5 little
Time, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitation: in settling tank, extracting solution precipitates 12 hours, extraction supernatant filters to triple effect steaming through 200 mesh filters
Sending out in device, precipitate presses offal treatment；
4) concentrate: when supernatant be concentrated in triple effect evaporator relative density be 1.05～1.10 (40 DEG C of mensuration) time,
By dilute clear paste in 200 mesh filters filter suction vacuum decompressioning and concentrating tank, addition ethanol, to alcohol content 60% (v/v), is placed,
Filter；Concentrate and mix and go out cream when being 1.10～1.22 (90 DEG C of mensuration) to relative density, to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01MPa, temperature: 78～82 DEG C, drying time 12～18 hours；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, puts into clear paste powder in trough type mixing machine with starch, stirs 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, pelletizes with 12 mesh stainless steel sifts, and 60～70 DEG C are dried 2 hours, take out, cool and i.e. obtain described granule
Agent.
Embodiment 3
A kind of Chinese medicine granules preventing and treating industrialized culture red fin east Disease of skin fester, by Herba Artemisiae Scopariae, Radix Bupleuri, Radix Sophorae Flavescentis,
Radix Isatidis, Cortex Moutan, Rhizoma Polygoni Cuspidati, Cortex Phellodendri, Flos Lonicerae, Galla Chinensis composition, wherein, Herba Artemisiae Scopariae 20kg, Radix Bupleuri 20kg, Radix Sophorae Flavescentis 18kg, plate
Blue root 12kg, Cortex Moutan 18kg, Rhizoma Polygoni Cuspidati 18kg, Cortex Phellodendri 6kg, Flos Lonicerae 11kg, Galla Chinensis 6kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating industrialized culture red fin east Disease of skin fester, specifically prepares
Step is as follows:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh Herba Artemisiae Scopariae 19kg, Radix Bupleuri 17kg, Radix Sophorae Flavescentis 15kg, Radix Isatidis 9kg, Cortex Moutan 14kg, Rhizoma Polygoni Cuspidati 13kg,
Cortex Phellodendri 3kg, Flos Lonicerae 10kg, Galla Chinensis 5kg are raw material, wash clean Chinese crude drug, pulverize, standby；
2) decocting: boiling, first decocts every tank adds water 8 times into medical material total amount, keeps 2 hours, carry after ebuillition of heated
Take liquid and filter entrance settling tank through 200 mesh filters；Second decocts the water heating extraction adding medical material amount 6 times, protects boiling 1.5 little
Time, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitation: in settling tank, extracting solution precipitates 12 hours, extraction supernatant filters to triple effect steaming through 200 mesh filters
Sending out in device, precipitate presses offal treatment；
4) concentrate: when supernatant be concentrated in triple effect evaporator relative density be 1.05～1.10 (40 DEG C of mensuration) time,
By dilute clear paste in 200 mesh filters filter suction vacuum decompressioning and concentrating tank, addition ethanol, to alcohol content 60% (v/v), is placed,
Filter；Concentrate and mix and go out cream when being 1.10～1.22 (90 DEG C of mensuration) to relative density, to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01MPa, temperature: 78～82 DEG C, drying time 12～18 hours；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, puts into clear paste powder in trough type mixing machine with starch, stirs 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, pelletizes with 12 mesh stainless steel sifts, and 60～70 DEG C are dried 2 hours, take out, cool and i.e. obtain described granule
Agent.
Embodiment 4 clinical trial
The consumption of the Chinese medicine granules of above-mentioned preventing and treating industrialized culture red fin east Disease of skin fester is by 60g/100kg
The ratio of body weight mixes pharmaceutical chemistry, and oral, being used in conjunction 5 days is a course for the treatment of.Reach to treat the purpose of disease by intestinal absorption after Kou Fu.
On June 28th, 2013, the batch production that area, Rongcheng, Shandong Province certain industrialized culture red fin east raiser raises
Cultivate the morbidity of red fin east, clinical symptoms: ill industrialized culture Takifugu rubripes caudal peduncle portion, trunk or head skin
Skin festers, and necrosis comes off, and severe patient festers and is deep into Musclar layer, and the sick fish kiss end having festers.It is typical case's ulcer disease after diagnosing.Then
Treating with Chinese medicine granules described in the embodiment of the present invention 2, after medication 2 days, the state of an illness is clearly better, the change of health color substantially, extremely
Rate of dying reduces by sky, and after 5 days, mortality rate is 0, is almost recovered.
Inventor is with Chinese herbal and crude drugs preparations preventing and treating industrialized culture red fin east Disease of skin fester, from our experimental result
See, no matter be prevention, or treatment, evident in efficacy, but also do not produce drug resistance, promoting through test of many times and little area should
With, achieve good effect, make fishing ground economic benefit significantly improve.
Claims (3)
1. the Chinese herbal and crude drugs preparations being used for preventing and treating industrialized culture red fin east Disease of skin fester, it is characterised in that: by such as
The Chinese crude drug of lower weight portion is prepared from: Herba Artemisiae Scopariae 12-22 part, Radix Bupleuri 16-20 part, Radix Sophorae Flavescentis 12-18, Radix Isatidis 8-12 part, Paeonia suffruticosa
Skin 12-18 part, Rhizoma Polygoni Cuspidati 12-18 part, Cortex Phellodendri 2-6 part, Flos Lonicerae 8-11 part, Galla Chinensis 2-6 part.
Chinese herbal and crude drugs preparations for preventing and treating industrialized culture red fin east Disease of skin fester the most according to claim 1,
It is characterized in that: be prepared from by the Chinese crude drug of following weight portion: Herba Artemisiae Scopariae 18 parts, Radix Bupleuri 18 parts, Radix Sophorae Flavescentis 16, Radix Isatidis 10 parts,
Cortex Moutan 16 parts, Rhizoma Polygoni Cuspidati 14 parts, Cortex Phellodendri 4 parts, Flos Lonicerae 9 parts, Galla Chinensis 4 parts.
Chinese herbal medicine system for preventing and treating industrialized culture red fin east Disease of skin fester the most according to claim 1 and 2
Agent, it is characterised in that: it is granule.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104435292A (en) * | 2014-12-29 | 2015-03-25 | 杨成胜 | Chinese herbal medicine preparation for preventing leech ulcer disease |
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2016
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104435292A (en) * | 2014-12-29 | 2015-03-25 | 杨成胜 | Chinese herbal medicine preparation for preventing leech ulcer disease |
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Application publication date: 20170104 |