CN106344669A - Chinese herbal medicine preparation for preventing and treating skin ulcer of offshore net cage cultured sebastes schlegeli - Google Patents
Chinese herbal medicine preparation for preventing and treating skin ulcer of offshore net cage cultured sebastes schlegeli Download PDFInfo
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Abstract
The invention discloses a Chinese herbal medicine preparation for preventing and treating skin ulcer of offshore net cage cultured sebastes schlegeli. The Chinese herbal medicine preparation is prepared from the following Chinese herbal medicines in parts by weight: 12 to 22 parts of herba artemisiae scopariae, 16 to 20 parts of radix bupleuri, 12 to 18 parts of herba andrographitis, 8 to 12 parts of radix isatidis, 12 to 18 parts of coxtex moutan, 12 to 18 parts of rhizoma polygoni cuspidati, 2 to 6 parts of radix achyranthis bidentatae, 8 to 11 parts of honeysuckle flower and 2 to 6 parts of liquorice root. The Chinese herbal medicine preparation has extremely remarkable effects of resisting bacteria and diminishing inflammation, and enhancing the immunity of a traditional Chinese herbal medicine reasonable formula and an effective treatment medicine of the skin ulcer of the offshore net cage cultured sebastes schlegeli is provided for an aquaculture industry; the Chinese herbal medicine preparation has the characteristics of rapid effect, accurate curative effect, no medicine residues and no toxic side effect. When the Chinese herbal medicine preparation provided by the invention is used, the Chinese herbal medicine preparation can be used for effectively controlling the skin ulcer of the offshore net cage cultured sebastes schlegeli and reducing the morbidity and death rate of the skin ulcer.
Description
Technical field
The invention belongs to fishery practical technique field, specifically, it is used for preventing and treating coastal waters cage culture particularly to one kind
Chinese herbal and crude drugs preparationses of the flat Disease of skin fester of Xu Shi and preparation method thereof.
Background technology
Cage culture Xu Shi flat skin in coastal waters includes epidermis and corium two-layer, and also contains a kind of special body of gland,
Substantial amounts of mucus can be secreted out of, make skin be rich in mucosity, also can form effective physical protection barrier on fish body surface simultaneously,
Protect fish body from the invasion and attack of pathogenic microorganism.Once cage culture Xu Shi in coastal waters puts down skin and sustains damage, easily infect thin
Bacterium and produce death.Skin ulceration is the dermatosiss that cage culture Xu Shi in coastal waters puts down more typically, is typically due to parasite and posts
Raw or fish body is subject to the infection such as mechanical injuries secondary bacterial, funguses to cause the inflammation of skin histology, and affected area is then downright bad, group
Knit the formation defect that comes off, erosion, deep is ulcer to shallow defect.Cage culture Xu Shi flat skin in coastal waters can be caused at present to burst
Rotten antibacterial majority belongs to gram negative bacteria, mainly has pseudomonass, Aeromonass, tarda, vibrio etc..Coastal waters net
After the case cultivation flat body surface of Xu Shi festers, basis of microscopic observation, it is possible to find infection fish body table meat fiber necrosis, dissolving,
Muscle fiber interstitial is broadening to some extent, edema occurs, simultaneously also with the leaching of the inflammatory cells such as lymphocyte and mononuclear cell
Profit.This disease is often concurrent with fish molds.In low temperature rainy season, position of festering is easy to long fish moldss.Rotten afterbody continues development then
May result in bacterial septicemia, each internal organs all may occur in which different degrees of pathological changes.
The flat Disease of skin fester of coastal waters cage culture Xu Shi, all can occur throughout the year, and it is big, for this to treat difficulty
The preventing and treating of disease must adhere to the principle of " putting prevention first, anti-overweighting is controlled ".If fish body table festers, treat such disease not only
Pathogenic bacterium in water body to be killed, more important point is the antibacterial killed at skin ulceration, takes antibacterials simultaneously orally and removes
Internal pathogenic bacterium.
How to be treated using western medicine antibiotics at this stage, although aquatic medicine controls relatively strictly, western medicine antibiotics are indiscriminate
With situation still extremely serious so that cage culture Xu Shi flat treatment difficulty in coastal waters increases, medicament residue problem is more and more heavier,
Cause seriously to threaten to food-safety problem.China's natural resources of Chinese medicinal materials enriches, by rationally being screened and prescription to Chinese medicine,
First-selected as the preventing and treating flat Disease of skin fester of coastal waters cage culture Xu Shi, will have very important production practices meaning.
Chinese herbal medicine belongs to natural drug, in application and the research of China, has accumulated rich experience.Using Chinese herbal medicine
The preventing and treating flat Disease of skin fester of coastal waters cage culture Xu Shi is increasingly subject to attention and the favor of people, is increasingly widely accepted,
It is that the mechanism of action unique with it, model of action and advantage are inseparable, puts it briefly, herbal control disease has adjustment and makees
With, strengthening vital QI to eliminate pathogenic factors, have no drug resistance and the incomparable feature of other medicines and the advantage such as nuisanceless, effect is good, and does not deposit
In the residue problem of antibiotic medicine, highly beneficial to the animal husbandry products export of China.In addition, Chinese herbal medicine also has price just
Preferably, wide material sources, the advantages of easy to use, are one of developing direction of fish medicine from now on.
Content of the invention
It is an object of the invention to provide a kind of medium-height grass for preventing and treating the flat Disease of skin fester of coastal waters cage culture Xu Shi
Medicine preparation.
The object of the present invention is achieved like this:
A kind of Chinese herbal and crude drugs preparationses for preventing and treating the flat Disease of skin fester of coastal waters cage culture Xu Shi, by following weight portion
Chinese crude drug is prepared from: Herba Artemisiae Scopariae 16-22 part, Radix Bupleuri 16-20 part, Herba Andrographis 12-18, Radix Isatidis 8-12 part, Cortex Moutan 12-18
Part, Rhizoma Polygoni Cuspidati 12-18 part, Radix Achyranthis Bidentatae 2-6 part, Flos Lonicerae 8-11 part, Radix Glycyrrhizae 2-6 part.
Preferably, the described Chinese herbal and crude drugs preparationses for preventing and treating the flat Disease of skin fester of coastal waters cage culture Xu Shi, by such as
The Chinese crude drug of lower weight portion is prepared from: 18 parts of Herba Artemisiae Scopariae, 18 parts of Radix Bupleuri, Herba Andrographis 16,10 parts of Radix Isatidis, 16 parts of Cortex Moutan, tiger
14 parts of cane, 4 parts of Radix Achyranthis Bidentatae, 9 parts of Flos Lonicerae, 4 parts of Radix Glycyrrhizae.
It is further preferred that the described Chinese herbal and crude drugs preparationses for preventing and treating the flat Disease of skin fester of coastal waters cage culture Xu Shi
It is granule.
The preparation method of the Chinese herbal and crude drugs preparationses that above-mentioned each Chinese crude drug preparation cost is invented, comprises the steps:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh the above-mentioned Chinese crude drug cleaning up by recipe quantity, pulverize, standby；
2) decoct: add water to cook, first decocts 8 times that every tank adds water as medical material total amount, keeps 2 hours, carry after ebuillition of heated
Take liquid to filter through 200 mesh filters and enter settling tank；Second decocts the water heating extraction adding 6 times of medical material amount, protects boiling 1.5 little
When, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitate: extract liquid precipitate 12 hours in settling tank, extract supernatant and filter through 200 mesh filters and steam to triple effect
Send out in device, precipitate presses offal treatment；
4) concentrate: when supernatant is concentrated into relative density for 1.05～1.10 (40 DEG C of mensure) in triple effect evaporator,
Dilute clear cream 200 mesh filter is filtered in suction vacuum decompressioning and concentrating tank, adds ethanol to alcohol content 60% (v/v), place,
Filtration；Concentrating and mix to relative density is to go out cream when 1.10～1.22 (90 DEG C of mensure), to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01mpa, temperature: 78～82 DEG C, 12～18 hours drying times；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, clear paste powder and starch is put in trough type mixing machine, stirs 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, is pelletized with 12 mesh stainless steel sifts, 60～70 DEG C of dryings 2 hours, takes out, cools and obtain final product described granule
Agent.
The consumption of the flat Disease of skin fester Chinese medicine granules of above-mentioned preventing and treating coastal waters cage culture Xu Shi is by 50-80g/
The ratio of 100kg body weight mixes pharmaceutical chemistry, allows cage culture Xu Shi flat mouth in coastal waters to take, and being used in conjunction 5-7 days is a course for the treatment of.
The present inventor prevents and treats the flat Disease of skin fester of coastal waters cage culture Xu Shi with Chinese herbal and crude drugs preparationses, from our experiment knot
Fruit see, application the present invention Chinese herbal and crude drugs preparationses can the flat Disease of skin fester of effective control coastal waters cage culture Xu Shi, reduce coastal waters
The M ＆ M of the flat Disease of skin fester of cage culture Xu Shi, but also do not produce drug resistance.The present invention is by tradition
Medicine reasonable formula, anti-inflammation, enhancing immunity effect extremely notable, be culture fishery provide a kind of coastal waters net cage support
Grow the effectively treatment medicine of the flat Disease of skin fester of Xu Shi, there is instant effect, curative effect really, no drug residue, without any side effects
Feature；Its preparation method is simple, the needs of suitable scale industrial production.
Specific embodiment
Further illustrate the present invention below by embodiment.Embodiments of the invention are only used for the present invention is described, and
It is not limitation of the present invention, under the concept thereof of the present invention, the present invention is broadly fallen into the simple modifications of preparation method of the present invention
Claimed scope.With reference to specific embodiment, technical scheme of the present invention is further described.
Embodiment 1
A kind of Chinese medicine granules of the flat Disease of skin fester of preventing and treating coastal waters cage culture Xu Shi, by Herba Artemisiae Scopariae, Radix Bupleuri, punching
Lotus, Radix Isatidis, Cortex Moutan, Rhizoma Polygoni Cuspidati, Radix Achyranthis Bidentatae, Flos Lonicerae, Radix Glycyrrhizae composition, wherein, Herba Artemisiae Scopariae 18kg, Radix Bupleuri 18kg, Herba Andrographis 16kg,
Radix Isatidis 10kg, Cortex Moutan 16kg, Rhizoma Polygoni Cuspidati 14kg, Radix Achyranthis Bidentatae 4kg, Flos Lonicerae 9kg, Radix Glycyrrhizae 4kg.
The preparation method of the Chinese medicine granules of the flat Disease of skin fester of above-mentioned preventing and treating coastal waters cage culture Xu Shi, concrete prepares
Step is as follows:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh clear Herba Artemisiae Scopariae 18kg, Radix Bupleuri 18kg, Herba Andrographis 16kg, Radix Isatidis 10kg, Cortex Moutan 16kg, Rhizoma Polygoni Cuspidati
14kg, Radix Achyranthis Bidentatae 4kg, Flos Lonicerae 9kg, Radix Glycyrrhizae 4kg are raw material, and wash clean Chinese crude drug is pulverized, standby；
2) decoct: add water to cook, first decocts 8 times that every tank adds water as medical material total amount, keeps 2 hours, carry after ebuillition of heated
Take liquid to filter through 200 mesh filters and enter settling tank；Second decocts the water heating extraction adding 6 times of medical material amount, protects boiling 1.5 little
When, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitate: extract liquid precipitate 12 hours in settling tank, extract supernatant and filter through 200 mesh filters and steam to triple effect
Send out in device, precipitate presses offal treatment；
4) concentrate: when supernatant is concentrated into relative density for 1.05～1.10 (40 DEG C of mensure) in triple effect evaporator,
Dilute clear cream 200 mesh filter is filtered in suction vacuum decompressioning and concentrating tank, adds ethanol to alcohol content 60% (v/v), place,
Filtration；Concentrating and mix to relative density is to go out cream when 1.10～1.22 (90 DEG C of mensure), to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01mpa, temperature: 78～82 DEG C, 12～18 hours drying times；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, clear paste powder and starch is put in trough type mixing machine, stirs 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, is pelletized with 12 mesh stainless steel sifts, 60～70 DEG C of dryings 2 hours, takes out, cools and obtain final product described granule
Agent.
Embodiment 2
A kind of Chinese medicine granules of the flat Disease of skin fester of preventing and treating coastal waters cage culture Xu Shi, by Herba Artemisiae Scopariae, Radix Bupleuri, punching
Lotus, Radix Isatidis, Cortex Moutan, Rhizoma Polygoni Cuspidati, Radix Achyranthis Bidentatae, Flos Lonicerae, Radix Glycyrrhizae composition, wherein, Herba Artemisiae Scopariae 19kg, Radix Bupleuri 17kg, Herba Andrographis 15kg,
Radix Isatidis 9kg, Cortex Moutan 14kg, Rhizoma Polygoni Cuspidati 13kg, Radix Achyranthis Bidentatae 3kg, Flos Lonicerae 10kg, Radix Glycyrrhizae 5kg.
The preparation method of the Chinese medicine granules of the flat Disease of skin fester of above-mentioned preventing and treating coastal waters cage culture Xu Shi, concrete prepares
Step is as follows:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh Herba Artemisiae Scopariae 19kg, Radix Bupleuri 17kg, Herba Andrographis 15kg, Radix Isatidis 9kg, Cortex Moutan 14kg, Rhizoma Polygoni Cuspidati
13kg, Radix Achyranthis Bidentatae 3kg, Flos Lonicerae 10kg, Radix Glycyrrhizae 5kg are raw material, and wash clean Chinese crude drug is pulverized, standby；
2) decoct: add water to cook, first decocts 8 times that every tank adds water as medical material total amount, keeps 2 hours, carry after ebuillition of heated
Take liquid to filter through 200 mesh filters and enter settling tank；Second decocts the water heating extraction adding 6 times of medical material amount, protects boiling 1.5 little
When, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitate: extract liquid precipitate 12 hours in settling tank, extract supernatant and filter through 200 mesh filters and steam to triple effect
Send out in device, precipitate presses offal treatment；
4) concentrate: when supernatant is concentrated into relative density for 1.05～1.10 (40 DEG C of mensure) in triple effect evaporator,
Dilute clear cream 200 mesh filter is filtered in suction vacuum decompressioning and concentrating tank, adds ethanol to alcohol content 60% (v/v), place,
Filtration；Concentrating and mix to relative density is to go out cream when 1.10～1.22 (90 DEG C of mensure), to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01mpa, temperature: 78～82 DEG C, 12～18 hours drying times；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, clear paste powder and starch is put in trough type mixing machine, stirs 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, is pelletized with 12 mesh stainless steel sifts, 60～70 DEG C of dryings 2 hours, takes out, cools and obtain final product described granule
Agent.
Embodiment 3
A kind of Chinese medicine granules of the flat Disease of skin fester of preventing and treating coastal waters cage culture Xu Shi, by Herba Artemisiae Scopariae, Radix Bupleuri, punching
Lotus, Radix Isatidis, Cortex Moutan, Rhizoma Polygoni Cuspidati, Radix Achyranthis Bidentatae, Flos Lonicerae, Radix Glycyrrhizae composition, wherein, Herba Artemisiae Scopariae 20kg, Radix Bupleuri 20kg, Herba Andrographis 18kg,
Radix Isatidis 12kg, Cortex Moutan 18kg, Rhizoma Polygoni Cuspidati 18kg, Radix Achyranthis Bidentatae 6kg, Flos Lonicerae 11kg, Radix Glycyrrhizae 6kg.
The preparation method of the Chinese medicine granules of the flat Disease of skin fester of above-mentioned preventing and treating coastal waters cage culture Xu Shi, concrete prepares
Step is as follows:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh Herba Artemisiae Scopariae 19kg, Radix Bupleuri 17kg, Herba Andrographis 15kg, Radix Isatidis 9kg, Cortex Moutan 14kg, Rhizoma Polygoni Cuspidati
13kg, Radix Achyranthis Bidentatae 3kg, Flos Lonicerae 10kg, Radix Glycyrrhizae 5kg are raw material, and wash clean Chinese crude drug is pulverized, standby；
2) decoct: add water to cook, first decocts 8 times that every tank adds water as medical material total amount, keeps 2 hours, carry after ebuillition of heated
Take liquid to filter through 200 mesh filters and enter settling tank；Second decocts the water heating extraction adding 6 times of medical material amount, protects boiling 1.5 little
When, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitate: extract liquid precipitate 12 hours in settling tank, extract supernatant and filter through 200 mesh filters and steam to triple effect
Send out in device, precipitate presses offal treatment；
4) concentrate: when supernatant is concentrated into relative density for 1.05～1.10 (40 DEG C of mensure) in triple effect evaporator,
Dilute clear cream 200 mesh filter is filtered in suction vacuum decompressioning and concentrating tank, adds ethanol to alcohol content 60% (v/v), place,
Filtration；Concentrating and mix to relative density is to go out cream when 1.10～1.22 (90 DEG C of mensure), to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01mpa, temperature: 78～82 DEG C, 12～18 hours drying times；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, clear paste powder and starch is put in trough type mixing machine, stirs 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, is pelletized with 12 mesh stainless steel sifts, 60～70 DEG C of dryings 2 hours, takes out, cools and obtain final product described granule
Agent.
Embodiment 4 clinical trial
The consumption of the Chinese medicine granules of the flat Disease of skin fester of above-mentioned preventing and treating coastal waters cage culture Xu Shi is by 60g/100kg
The ratio of body weight mixes pharmaceutical chemistry, is administered orally, and being used in conjunction 5 days is a course for the treatment of.Reach the purpose for the treatment of disease by intestinal absorption after oral.
On June 28th, 2013, the coastal waters net that the Shandong Province Rongcheng area flat raiser of certain coastal waters cage culture Xu Shi raises
Case cultivation Xu Shi puts down morbidity, clinical symptoms: the coastal waters cage culture Xu Shi butterfish caudal peduncle portion of illness, trunk or head skin
Skin festers, and necrosis comes off, and severe patient festers and is deep into Musclar layer, festers in some disease fish kiss ends.It is typical ulcer disease after diagnosing.Then
Treated with Chinese medicine granules described in the embodiment of the present invention 2, after medication 2 days, the state of an illness is clearly better, body color change substantially, extremely
Rate of dying reduces by sky, and after 5 days, mortality rate is 0, is almost recovered.
Inventor prevents and treats the flat Disease of skin fester of coastal waters cage culture Xu Shi with Chinese herbal and crude drugs preparationses, from our experimental result
See, no matter being prevention, or treatment, evident in efficacy, but also do not produce drug resistance, promoting through test of many times and small area should
With achieving good effect, so that fishing ground economic benefit is significantly improved.
Claims (3)
1. a kind of Chinese herbal and crude drugs preparationses for preventing and treating the flat Disease of skin fester of coastal waters cage culture Xu Shi it is characterised in that: by such as
The Chinese crude drug of lower weight portion is prepared from: Herba Artemisiae Scopariae 12-22 part, Radix Bupleuri 16-20 part, Herba Andrographis 12-18, Radix Isatidis 8-12 part, male
Cortex Moutan 12-18 part, Rhizoma Polygoni Cuspidati 12-18 part, Radix Achyranthis Bidentatae 2-6 part, Flos Lonicerae 8-11 part, Radix Glycyrrhizae 2-6 part.
2. the Chinese herbal and crude drugs preparationses for preventing and treating the flat Disease of skin fester of coastal waters cage culture Xu Shi according to claim 1,
It is characterized in that: it is prepared from by the Chinese crude drug of following weight portion: 18 parts of Herba Artemisiae Scopariae, 18 parts of Radix Bupleuri, Herba Andrographis 16, Radix Isatidis 10
Part, 16 parts of Cortex Moutan, 14 parts of Rhizoma Polygoni Cuspidati, 4 parts of Radix Achyranthis Bidentatae, 9 parts of Flos Lonicerae, 4 parts of Radix Glycyrrhizae.
3. the Chinese herbal medicine system for preventing and treating the flat Disease of skin fester of coastal waters cage culture Xu Shi according to claim 1 and 2
Agent it is characterised in that: it be granule.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610874799.6A CN106344669A (en) | 2016-09-30 | 2016-09-30 | Chinese herbal medicine preparation for preventing and treating skin ulcer of offshore net cage cultured sebastes schlegeli |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610874799.6A CN106344669A (en) | 2016-09-30 | 2016-09-30 | Chinese herbal medicine preparation for preventing and treating skin ulcer of offshore net cage cultured sebastes schlegeli |
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| Publication Number | Publication Date |
|---|---|
| CN106344669A true CN106344669A (en) | 2017-01-25 |
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ID=57866025
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610874799.6A Withdrawn CN106344669A (en) | 2016-09-30 | 2016-09-30 | Chinese herbal medicine preparation for preventing and treating skin ulcer of offshore net cage cultured sebastes schlegeli |
Country Status (1)
| Country | Link |
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| CN (1) | CN106344669A (en) |
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2016
- 2016-09-30 CN CN201610874799.6A patent/CN106344669A/en not_active Withdrawn
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| C06 | Publication | ||
| PB01 | Publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20170125 |
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| WW01 | Invention patent application withdrawn after publication |