CN106334013A - Chinese herbal medicine preparation for preventing skin fester of pond culture Takifugu flavidus - Google Patents
Chinese herbal medicine preparation for preventing skin fester of pond culture Takifugu flavidus Download PDFInfo
- Publication number
- CN106334013A CN106334013A CN201610874911.6A CN201610874911A CN106334013A CN 106334013 A CN106334013 A CN 106334013A CN 201610874911 A CN201610874911 A CN 201610874911A CN 106334013 A CN106334013 A CN 106334013A
- Authority
- CN
- China
- Prior art keywords
- parts
- pond culture
- chinese herbal
- herbal medicine
- skin fester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 29
- 241000411851 herbal medicine Species 0.000 title abstract description 9
- 241000054450 Takifugu flavidus Species 0.000 title abstract 4
- 239000003814 drug Substances 0.000 claims abstract description 42
- 241000723353 Chrysanthemum Species 0.000 claims description 35
- 235000007516 Chrysanthemum Nutrition 0.000 claims description 35
- 201000010099 disease Diseases 0.000 claims description 31
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 31
- 229940079593 drug Drugs 0.000 claims description 23
- 239000008187 granular material Substances 0.000 claims description 15
- 241000628997 Flos Species 0.000 claims description 13
- 230000000694 effects Effects 0.000 abstract description 18
- 230000008901 benefit Effects 0.000 abstract description 5
- 230000003115 biocidal effect Effects 0.000 abstract description 2
- 230000036039 immunity Effects 0.000 abstract description 2
- 241000427159 Achyranthes Species 0.000 abstract 1
- 241000205585 Aquilegia canadensis Species 0.000 abstract 1
- 235000008658 Artemisia capillaris Nutrition 0.000 abstract 1
- 241000092668 Artemisia capillaris Species 0.000 abstract 1
- 235000018958 Gardenia augusta Nutrition 0.000 abstract 1
- 240000001972 Gardenia jasminoides Species 0.000 abstract 1
- 244000292697 Polygonum aviculare Species 0.000 abstract 1
- 235000006386 Polygonum aviculare Nutrition 0.000 abstract 1
- 241000246044 Sophora flavescens Species 0.000 abstract 1
- 238000009360 aquaculture Methods 0.000 abstract 1
- 244000144974 aquaculture Species 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 229940126680 traditional chinese medicines Drugs 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 44
- 210000003491 skin Anatomy 0.000 description 26
- 239000000843 powder Substances 0.000 description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 13
- 239000006071 cream Substances 0.000 description 12
- 239000002244 precipitate Substances 0.000 description 12
- 241000251468 Actinopterygii Species 0.000 description 10
- 239000012567 medical material Substances 0.000 description 9
- 229920002472 Starch Polymers 0.000 description 8
- 238000001035 drying Methods 0.000 description 8
- 239000007788 liquid Substances 0.000 description 8
- 235000019698 starch Nutrition 0.000 description 8
- 239000008107 starch Substances 0.000 description 8
- 238000003756 stirring Methods 0.000 description 8
- 239000006228 supernatant Substances 0.000 description 8
- 239000000203 mixture Substances 0.000 description 7
- 239000002994 raw material Substances 0.000 description 7
- 206010013786 Dry skin Diseases 0.000 description 4
- 238000009835 boiling Methods 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 239000012141 concentrate Substances 0.000 description 4
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- 238000001914 filtration Methods 0.000 description 4
- 239000012467 final product Substances 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 239000007779 soft material Substances 0.000 description 4
- 229910001220 stainless steel Inorganic materials 0.000 description 4
- 239000010935 stainless steel Substances 0.000 description 4
- 238000003860 storage Methods 0.000 description 4
- 206010059866 Drug resistance Diseases 0.000 description 3
- 206010040943 Skin Ulcer Diseases 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 229940088710 antibiotic agent Drugs 0.000 description 3
- 241000283690 Bos taurus Species 0.000 description 2
- 208000025865 Ulcer Diseases 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 244000052616 bacterial pathogen Species 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 210000000629 knee joint Anatomy 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000017074 necrotic cell death Effects 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 241000607534 Aeromonas Species 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010048768 Dermatosis Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 241000589516 Pseudomonas Species 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- 241000607598 Vibrio Species 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000003640 drug residue Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 210000004969 inflammatory cell Anatomy 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000031891 intestinal absorption Effects 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000005087 mononuclear cell Anatomy 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 210000001087 myotubule Anatomy 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 230000024241 parasitism Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 208000013223 septicemia Diseases 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/634—Forsythia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/744—Gardenia
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Insects & Arthropods (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a Chinese herbal medicine preparation for preventing skin fester of pond culture Takifugu flavidus. The Chinese herbal medicine preparation is prepared from, by weight parts, 12-22 parts of artemisia capillaris,16-20 parts of radix bupleuri, 12-18 parts of sophora flavescens, 8-12 parts of fructus forsythiae, 12-18 parts of gardenia jasminoides, 12-18 parts of gentrin knotweed, 2-6 parts of achyranthes root, 8-11 parts of honeysuckle and 2-6 parts of gallnut. Conventional traditional Chinese medicines are reasonably composited, effects of antibiosis and antiphlogosis and immunity enhancement are very remarkable, and the effective therapeutic medicine is provided for treating pond culture Takifugu flavidus for the aquaculture industry. The Chinese herbal medicine preparation has the advantages of taking effect quickly, being real in curative effect and free of medicinal residue and having no toxic or side effect. By applying the Chinese herbal medicine preparation, the skin fester of pond culture Takifugu flavidus can be effectively controlled, and the skin fester morbidity and mortality are reduced.
Description
Technical field
The invention belongs to fishery practical technique field, specifically, it is used for preventing and treating pond culture chrysanthemum Huang particularly to one kind
Chinese herbal and crude drugs preparationses of east Disease of skin fester and preparation method thereof.
Background technology
The skin in pond culture chrysanthemum Huang east includes epidermis and corium two-layer, and also contains a kind of special body of gland, energy
Secret out of substantial amounts of mucus, make skin be rich in mucosity, also can form effective physical protection barrier on fish body surface simultaneously, protect
Shield fish body is from the invasion and attack of pathogenic microorganism.Once pond culture chrysanthemum Huang east skin sustains damage, easily bacterial infection and
Produce dead.Skin ulceration is pond culture chrysanthemum Huang east dermatosiss more typically, is typically due to parasite parasitism or fish
Body is subject to the infection such as mechanical injuries secondary bacterial, funguses to cause the inflammation of skin histology, and affected area is then downright bad, tissue loss
Form defect, erosion, deep is ulcer to shallow defect.The antibacterial of pond culture chrysanthemum Huang east skin ulceration can be caused at present
Majority belongs to gram negative bacteria, mainly has pseudomonass, Aeromonass, tarda, vibrio etc..The yellow east of pond culture chrysanthemum
After cube table festers, basis of microscopic observation, it is possible to find infection fish body table meat fiber necrosis, dissolving, muscle fiber interstitial
Broadening to some extent, there is edema, simultaneously also with the infiltration of the inflammatory cells such as lymphocyte and mononuclear cell.This disease is often
Concurrent with fish molds.In low temperature rainy season, position of festering is easy to long fish moldss.Rotten afterbody continuation development then may result in bacillary
Septicemia, each internal organs all may occur in which different degrees of pathological changes.
The Disease of skin fester in pond culture chrysanthemum Huang east, all can occur throughout the year, and it is big, for this disease to treat difficulty
Preventing and treating must adhere to the principle of " put prevention first, anti-overweight control ".If fish body table festers, treat such disease and not only will
Kill the pathogenic bacterium in water body, more important point is the antibacterial killed at skin ulceration, take antibacterials simultaneously orally and remove body
Interior pathogenic bacterium.
How to be treated using western medicine antibiotics at this stage, although aquatic medicine controls relatively strictly, western medicine antibiotics are indiscriminate
With situation still extremely serious so that the treatment difficulty in pond culture chrysanthemum Huang east increases, medicament residue problem is more and more heavier, gives
Food-safety problem causes seriously to threaten.China's natural resources of Chinese medicinal materials enriches, and by rationally being screened and prescription to Chinese medicine, makees
First-selected for preventing and treating pond culture chrysanthemum Huang east Disease of skin fester, will have very important production practices meaning.
Chinese herbal medicine belongs to natural drug, in application and the research of China, has accumulated rich experience.Using Chinese herbal medicine
Preventing and treating pond culture chrysanthemum Huang east Disease of skin fester is increasingly subject to attention and the favor of people, is increasingly widely accepted, is
The mechanism of action unique with it, model of action and advantage are inseparable, put it briefly, and herbal control disease has adjustment and makees
With, strengthening vital QI to eliminate pathogenic factors, have no drug resistance and the incomparable feature of other medicines and the advantage such as nuisanceless, effect is good, and does not deposit
In the residue problem of antibiotic medicine, highly beneficial to the animal husbandry products export of China.In addition, Chinese herbal medicine also has price just
Preferably, wide material sources, the advantages of easy to use, are one of developing direction of fish medicine from now on.
Content of the invention
It is an object of the invention to provide a kind of Chinese herbal medicine for preventing and treating pond culture chrysanthemum Huang east Disease of skin fester
Preparation.
The object of the present invention is achieved like this:
A kind of Chinese herbal and crude drugs preparationses for preventing and treating pond culture chrysanthemum Huang east Disease of skin fester, by following weight portion
Medical material is prepared from: Herba Artemisiae Scopariae 16-22 part, Radix Bupleuri 16-20 part, Radix Sophorae Flavescentiss 12-18, Fructus Forsythiae 8-12 part, Fructus Gardeniae 12-18 part, Rhizoma Polygoni Cuspidati 12-
18 parts, Radix Achyranthis Bidentatae 2-6 part, Flos Lonicerae 8-11 part, Galla Chinensiss 2-6 part.
Preferably, the described Chinese herbal and crude drugs preparationses for preventing and treating pond culture chrysanthemum Huang east Disease of skin fester, by as follows
The Chinese crude drug of weight portion is prepared from: 18 parts of Herba Artemisiae Scopariae, 18 parts of Radix Bupleuri, Radix Sophorae Flavescentiss 16,10 parts of Fructus Forsythiae, 16 parts of Fructus Gardeniae, 14 parts of Rhizoma Polygoni Cuspidati, cattle
4 parts of knee joint, 9 parts of Flos Lonicerae, 4 parts of Galla Chinensiss.
It is further preferred that the described Chinese herbal and crude drugs preparationses for preventing and treating pond culture chrysanthemum Huang east Disease of skin fester are
Granule.
The preparation method of the Chinese herbal and crude drugs preparationses that above-mentioned each Chinese crude drug preparation cost is invented, comprises the steps:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh the above-mentioned Chinese crude drug cleaning up by recipe quantity, pulverize, standby；
2) decoct: add water to cook, first decocts 8 times that every tank adds water as medical material total amount, keeps 2 hours, carry after ebuillition of heated
Take liquid to filter through 200 mesh filters and enter settling tank；Second decocts the water heating extraction adding 6 times of medical material amount, protects boiling 1.5 little
When, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitate: extract liquid precipitate 12 hours in settling tank, extract supernatant and filter through 200 mesh filters and steam to triple effect
Send out in device, precipitate presses offal treatment；
4) concentrate: when supernatant is concentrated into relative density for 1.05～1.10 (40 DEG C of mensure) in triple effect evaporator,
Dilute clear cream 200 mesh filter is filtered in suction vacuum decompressioning and concentrating tank, adds ethanol to alcohol content 60% (v/v), place,
Filtration；Concentrating and mix to relative density is to go out cream when 1.10～1.22 (90 DEG C of mensure), to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01mpa, temperature: 78～82 DEG C, 12～18 hours drying times；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, clear paste powder and starch is put in trough type mixing machine, stirs 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, is pelletized with 12 mesh stainless steel sifts, 60～70 DEG C of dryings 2 hours, takes out, cools and obtain final product described granule
Agent.
The consumption of above-mentioned preventing and treating pond culture chrysanthemum Huang east Disease of skin fester Chinese medicine granules is by 50-80g/100kg
The ratio of body weight mixes pharmaceutical chemistry, allows pond culture chrysanthemum Huang east to be administered orally, being used in conjunction 5-7 days is a course for the treatment of.
The present inventor prevents and treats pond culture chrysanthemum Huang east Disease of skin fester with Chinese herbal and crude drugs preparationses, from our experimental result
See, the Chinese herbal and crude drugs preparationses of the application present invention can effective control pond culture chrysanthemum Huang east Disease of skin fester, reduce pond culture
The M ＆ M of chrysanthemum Huang east Disease of skin fester, but also do not produce drug resistance.The present invention is reasonable by Chinese medicine
Prescription, anti-inflammation, enhancing immunity effect extremely notable, be that culture fishery provides a kind of pond culture chrysanthemum Huang east
The effectively treatment medicine of Disease of skin fester, has the characteristics that instant effect, curative effect really, no drug residue, without any side effects；Its
Preparation method is simple, the needs of suitable scale industrial production.
Specific embodiment
Further illustrate the present invention below by embodiment.Embodiments of the invention are only used for the present invention is described, and
It is not limitation of the present invention, under the concept thereof of the present invention, the present invention is broadly fallen into the simple modifications of preparation method of the present invention
Claimed scope.With reference to specific embodiment, technical scheme of the present invention is further described.
Embodiment 1
A kind of Chinese medicine granules of preventing and treating pond culture chrysanthemum Huang east Disease of skin fester, by Herba Artemisiae Scopariae, Radix Bupleuri, Radix Sophorae Flavescentiss, company
Stick up, Fructus Gardeniae, Rhizoma Polygoni Cuspidati, Radix Achyranthis Bidentatae, Flos Lonicerae, Galla Chinensiss composition, wherein, Herba Artemisiae Scopariae 18kg, Radix Bupleuri 18kg, Radix Sophorae Flavescentiss 16kg, Fructus Forsythiae 10kg,
Fructus Gardeniae 16kg, Rhizoma Polygoni Cuspidati 14kg, Radix Achyranthis Bidentatae 4kg, Flos Lonicerae 9kg, Galla Chinensiss 4kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating pond culture chrysanthemum Huang east Disease of skin fester, concrete preparation step
Suddenly as follows:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh clear Herba Artemisiae Scopariae 18kg, Radix Bupleuri 18kg, Radix Sophorae Flavescentiss 16kg, Fructus Forsythiae 10kg, Fructus Gardeniae 16kg, Rhizoma Polygoni Cuspidati 14kg, cattle
Knee joint 4kg, Flos Lonicerae 9kg, Galla Chinensiss 4kg are raw material, and wash clean Chinese crude drug is pulverized, standby；
2) decoct: add water to cook, first decocts 8 times that every tank adds water as medical material total amount, keeps 2 hours, carry after ebuillition of heated
Take liquid to filter through 200 mesh filters and enter settling tank；Second decocts the water heating extraction adding 6 times of medical material amount, protects boiling 1.5 little
When, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitate: extract liquid precipitate 12 hours in settling tank, extract supernatant and filter through 200 mesh filters and steam to triple effect
Send out in device, precipitate presses offal treatment；
4) concentrate: when supernatant is concentrated into relative density for 1.05～1.10 (40 DEG C of mensure) in triple effect evaporator,
Dilute clear cream 200 mesh filter is filtered in suction vacuum decompressioning and concentrating tank, adds ethanol to alcohol content 60% (v/v), place,
Filtration；Concentrating and mix to relative density is to go out cream when 1.10～1.22 (90 DEG C of mensure), to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01mpa, temperature: 78～82 DEG C, 12～18 hours drying times；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, clear paste powder and starch is put in trough type mixing machine, stirs 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, is pelletized with 12 mesh stainless steel sifts, 60～70 DEG C of dryings 2 hours, takes out, cools and obtain final product described granule
Agent.
Embodiment 2
A kind of Chinese medicine granules of preventing and treating pond culture chrysanthemum Huang east Disease of skin fester, by Herba Artemisiae Scopariae, Radix Bupleuri, Radix Sophorae Flavescentiss, company
Stick up, Fructus Gardeniae, Rhizoma Polygoni Cuspidati, Radix Achyranthis Bidentatae, Flos Lonicerae, Galla Chinensiss composition, wherein, Herba Artemisiae Scopariae 19kg, Radix Bupleuri 17kg, Radix Sophorae Flavescentiss 15kg, Fructus Forsythiae 9kg,
Fructus Gardeniae 14kg, Rhizoma Polygoni Cuspidati 13kg, Radix Achyranthis Bidentatae 3kg, Flos Lonicerae 10kg, Galla Chinensiss 5kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating pond culture chrysanthemum Huang east Disease of skin fester, concrete preparation step
Suddenly as follows:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh Herba Artemisiae Scopariae 19kg, Radix Bupleuri 17kg, Radix Sophorae Flavescentiss 15kg, Fructus Forsythiae 9kg, Fructus Gardeniae 14kg, Rhizoma Polygoni Cuspidati 13kg, Radix Achyranthis Bidentatae
3kg, Flos Lonicerae 10kg, Galla Chinensiss 5kg are raw material, and wash clean Chinese crude drug is pulverized, standby；
2) decoct: add water to cook, first decocts 8 times that every tank adds water as medical material total amount, keeps 2 hours, carry after ebuillition of heated
Take liquid to filter through 200 mesh filters and enter settling tank；Second decocts the water heating extraction adding 6 times of medical material amount, protects boiling 1.5 little
When, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitate: extract liquid precipitate 12 hours in settling tank, extract supernatant and filter through 200 mesh filters and steam to triple effect
Send out in device, precipitate presses offal treatment；
4) concentrate: when supernatant is concentrated into relative density for 1.05～1.10 (40 DEG C of mensure) in triple effect evaporator,
Dilute clear cream 200 mesh filter is filtered in suction vacuum decompressioning and concentrating tank, adds ethanol to alcohol content 60% (v/v), place,
Filtration；Concentrating and mix to relative density is to go out cream when 1.10～1.22 (90 DEG C of mensure), to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01mpa, temperature: 78～82 DEG C, 12～18 hours drying times；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, clear paste powder and starch is put in trough type mixing machine, stirs 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, is pelletized with 12 mesh stainless steel sifts, 60～70 DEG C of dryings 2 hours, takes out, cools and obtain final product described granule
Agent.
Embodiment 3
A kind of Chinese medicine granules of preventing and treating pond culture chrysanthemum Huang east Disease of skin fester, by Herba Artemisiae Scopariae, Radix Bupleuri, Radix Sophorae Flavescentiss, company
Stick up, Fructus Gardeniae, Rhizoma Polygoni Cuspidati, Radix Achyranthis Bidentatae, Flos Lonicerae, Galla Chinensiss composition, wherein, Herba Artemisiae Scopariae 20kg, Radix Bupleuri 20kg, Radix Sophorae Flavescentiss 18kg, Fructus Forsythiae 12kg,
Fructus Gardeniae 18kg, Rhizoma Polygoni Cuspidati 18kg, Radix Achyranthis Bidentatae 6kg, Flos Lonicerae 11kg, Galla Chinensiss 6kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating pond culture chrysanthemum Huang east Disease of skin fester, concrete preparation step
Suddenly as follows:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh Herba Artemisiae Scopariae 19kg, Radix Bupleuri 17kg, Radix Sophorae Flavescentiss 15kg, Fructus Forsythiae 9kg, Fructus Gardeniae 14kg, Rhizoma Polygoni Cuspidati 13kg, Radix Achyranthis Bidentatae
3kg, Flos Lonicerae 10kg, Galla Chinensiss 5kg are raw material, and wash clean Chinese crude drug is pulverized, standby；
2) decoct: add water to cook, first decocts 8 times that every tank adds water as medical material total amount, keeps 2 hours, carry after ebuillition of heated
Take liquid to filter through 200 mesh filters and enter settling tank；Second decocts the water heating extraction adding 6 times of medical material amount, protects boiling 1.5 little
When, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitate: extract liquid precipitate 12 hours in settling tank, extract supernatant and filter through 200 mesh filters and steam to triple effect
Send out in device, precipitate presses offal treatment；
4) concentrate: when supernatant is concentrated into relative density for 1.05～1.10 (40 DEG C of mensure) in triple effect evaporator,
Dilute clear cream 200 mesh filter is filtered in suction vacuum decompressioning and concentrating tank, adds ethanol to alcohol content 60% (v/v), place,
Filtration；Concentrating and mix to relative density is to go out cream when 1.10～1.22 (90 DEG C of mensure), to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01mpa, temperature: 78～82 DEG C, 12～18 hours drying times；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, clear paste powder and starch is put in trough type mixing machine, stirs 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, is pelletized with 12 mesh stainless steel sifts, 60～70 DEG C of dryings 2 hours, takes out, cools and obtain final product described granule
Agent.
Embodiment 4 clinical trial
The consumption of the Chinese medicine granules of above-mentioned preventing and treating pond culture chrysanthemum Huang east Disease of skin fester is by 60g/100kg body
The ratio of weight mixes pharmaceutical chemistry, is administered orally, and being used in conjunction 5 days is a course for the treatment of.Reach the purpose for the treatment of disease by intestinal absorption after oral.
On June 28th, 2013, the pond culture that certain pond culture chrysanthemum Huang east raiser of Shandong Province Rongcheng area raises
The east morbidity of chrysanthemum Huang, clinical symptoms: ill pond culture chrysanthemum yellow east fish tail shank, trunk or skin of head are burst
Rotten, necrosis comes off, and severe patient festers and is deep into Musclar layer, festers in some disease fish kiss ends.It is typical ulcer disease after diagnosing.Then use this
After Chinese medicine granules treatment, medication 2 days described in inventive embodiments 2, the state of an illness is clearly better, body color change substantially, mortality rate
Reduce by sky, after 5 days, mortality rate is 0, is almost recovered.
Inventor prevents and treats pond culture chrysanthemum Huang east Disease of skin fester with Chinese herbal and crude drugs preparationses, from our experimental result
See, no matter being prevention, or treatment, evident in efficacy, but also do not produce drug resistance, promoting through test of many times and small area should
With achieving good effect, so that fishing ground economic benefit is significantly improved.
Claims (3)
1. a kind of Chinese herbal and crude drugs preparationses for preventing and treating pond culture chrysanthemum Huang east Disease of skin fester it is characterised in that: by as follows
The Chinese crude drug of weight portion is prepared from: Herba Artemisiae Scopariae 12-22 part, Radix Bupleuri 16-20 part, Radix Sophorae Flavescentiss 12-18, Fructus Forsythiae 8-12 part, Fructus Gardeniae 12-18
Part, Rhizoma Polygoni Cuspidati 12-18 part, Radix Achyranthis Bidentatae 2-6 part, Flos Lonicerae 8-11 part, Galla Chinensiss 2-6 part.
2. the Chinese herbal and crude drugs preparationses for preventing and treating pond culture chrysanthemum Huang east Disease of skin fester according to claim 1, its
It is characterised by: be prepared from by the Chinese crude drug of following weight portion: 18 parts of Herba Artemisiae Scopariae, 18 parts of Radix Bupleuri, Radix Sophorae Flavescentiss 16,10 parts of Fructus Forsythiae, Fructus Gardeniae
16 parts, 14 parts of Rhizoma Polygoni Cuspidati, 4 parts of Radix Achyranthis Bidentatae, 9 parts of Flos Lonicerae, 4 parts of Galla Chinensiss.
3. the Chinese herbal and crude drugs preparationses for preventing and treating pond culture chrysanthemum Huang east Disease of skin fester according to claim 1 and 2,
It is characterized in that: it is granule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610874911.6A CN106334013A (en) | 2016-09-30 | 2016-09-30 | Chinese herbal medicine preparation for preventing skin fester of pond culture Takifugu flavidus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610874911.6A CN106334013A (en) | 2016-09-30 | 2016-09-30 | Chinese herbal medicine preparation for preventing skin fester of pond culture Takifugu flavidus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106334013A true CN106334013A (en) | 2017-01-18 |
Family
ID=57839808
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610874911.6A Withdrawn CN106334013A (en) | 2016-09-30 | 2016-09-30 | Chinese herbal medicine preparation for preventing skin fester of pond culture Takifugu flavidus |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106334013A (en) |
-
2016
- 2016-09-30 CN CN201610874911.6A patent/CN106334013A/en not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104971132B (en) | It is a kind of for preventing and treating the Chinese materia medica preparation of long octopus Disease of skin fester | |
| CN104887958A (en) | Traditional Chinese medicine preparation for treating enteritis of Chinese softshell turtles and preparation method of traditional Chinese medicine preparation | |
| CN106266138A (en) | A kind of Chinese herbal and crude drugs preparations for preventing and treating industrialized culture left-eyed flounder Disease of skin fester | |
| CN106334005A (en) | Chinese herbal medicine preparation for preventing skin fester of industrial culture sebastes schlegeli | |
| CN106334013A (en) | Chinese herbal medicine preparation for preventing skin fester of pond culture Takifugu flavidus | |
| CN106334014A (en) | Chinese herbal medicine preparation for preventing skin fester of industrial cultureTakifugu flavidus | |
| CN106420966A (en) | Chinese herbal medicine preparation for preventing common diseases of pond-cultured Fenneropenaeus chinensiss | |
| CN106266146A (en) | A kind of Chinese herbal and crude drugs preparations for preventing and treating plant modification Concha Tridacna squamosa Common Diseases | |
| CN106265984A (en) | A kind of Chinese herbal and crude drugs preparations for preventing and treating pond culture Penaeus vannamei Common Diseases | |
| CN106377601A (en) | Traditional Chinese herbal medicine preparation for preventing and treating skin ulceration of flatfish cultured in offshore cages | |
| CN106361873A (en) | Chinese herbal medicine preparation for preventing and controlling skin fester disease of black sea bream cultured in inshore net cage | |
| CN106344669A (en) | Chinese herbal medicine preparation for preventing and treating skin ulcer of offshore net cage cultured sebastes schlegeli | |
| CN106361810A (en) | Chinese herbal medicine preparation for preventing and treating skin fester diseases of pseudosciaena crocea in industrial aquaculture | |
| CN106266083A (en) | A kind of Chinese herbal and crude drugs preparations for preventing and treating pond culture red fin east Disease of skin fester | |
| CN106334004A (en) | Chinese herbal medicine preparation for preventing skin fester of industrial culture sebastes schlegeli | |
| CN106334017A (en) | Chinese herbal medicine preparation for preventing skin fester of offshore cage culture fugu rubripes | |
| CN106309641A (en) | Chinese herbal medicine preparation for preventing and treating skin fester disease of offshore cage-cultured takifugu flavidus | |
| CN106265965A (en) | A kind of Chinese herbal and crude drugs preparations for preventing and treating industrialized culture black porgy Disease of skin fester | |
| CN106266145A (en) | A kind of Chinese herbal and crude drugs preparations for preventing and treating plant modification green grass or young crops willow clam Common Diseases | |
| CN106266139A (en) | A kind of Chinese herbal and crude drugs preparations for preventing and treating industrialized culture red fin east Disease of skin fester | |
| CN103432294A (en) | Traditional Chinese medicine oral liquid for treating prawn eye disease and preparation method thereof | |
| CN106266005A (en) | A kind of Chinese herbal and crude drugs preparations for preventing and treating coastal waters cage culture Paralichthys olivaceus Disease of skin fester | |
| CN106309580A (en) | Chinese herbal medicine preparation for preventing and treating common diseases of pond-cultured portunus trituberculatus | |
| CN106361834A (en) | Chinese herbal preparation for preventing and treating common diseases generated in industrialized aquaculture of penaeus vannamei | |
| CN106377591A (en) | Chinese herbal medicine preparation for preventing and controlling sepia esculenta skin fester diseases |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20170118 |
|
| WW01 | Invention patent application withdrawn after publication |