CN106377591A - Chinese herbal medicine preparation for preventing and controlling sepia esculenta skin fester diseases - Google Patents
Chinese herbal medicine preparation for preventing and controlling sepia esculenta skin fester diseases Download PDFInfo
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
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Abstract
The invention discloses a Chinese herbal medicine preparation for preventing and controlling sepia esculenta skin fester diseases. The Chinese herbal medicine preparation is prepared from the following Chinese herbal medicines in parts by weight: 16 to 20 parts of isatis root, 16 to 20 parts of fructus gardeniae, 12 to 18 parts of radix sophorae flavescentis, 8 to 12 parts of herba andrographis, 12 to 18 parts of fructus gardeniae, 12 to 18 parts of rhizoma polygoni cuspidati, 2 to 6 parts of radix achyranthis bidentatae, 8 to 11 parts of taraxacum mongolicum, 2 to 6 parts of Chinese gall, and 8 to 20 parts of liquorice root. The Chinese herbal medicine preparation has the advantages that by utilizing the reasonable compounding of traditional Chinese herbal medicines, the sepia esculenta skin fester problem can be prevented and controlled by disinfection and sterilization; the remaining of poisonous and harmful chemical agent in pool water and sepia esculenta is avoided; through using the Chinese herbal medicine preparation provided by the invention, the sepia esculenta skin fester diseases can be effectively prevented and controlled, the survival rate and spawning rate of the sepia esculenta are increased, and the important significance is provided for the propagation of the sepia esculenta.
Description
Technical field
The invention belongs to fishery practical technique field, specifically, it is used for preventing and treating golden cuttlefish skin particularly to one kind and burst
Chinese herbal and crude drugs preparationses of rotten disease and preparation method thereof.
Background technology
Golden cuttlefish Sepia esculenta (Hoyle 1885) also known as cuttlefish, mullet, belong to Mollusca, Cephalopoda, sheath
Subclass, Sepiida, Sepiidae, Sepia, are distributed in Bohai and Yellow Seas, the East Sea, the South Sea, Japanese Science Society and the Philippines sea
Domain, is also the maximum sepiellae seu sepiae of economic worth in northern China marine site, once together with Carnis Pseudosciaenae, Carnis Pseudosciaenae, Trichiurus haumela and be referred to as China
One of traditional four big fishery, are important fished species.But since the eighties in 20th century, due to overfishing and marine environment
The many reasons such as destruction, its stock number substantially fails, and yield drastically declines, and current golden cuttlefish has disappeared in many marine sites.
Because golden cuttlefish has delicious meat, the feature that is of high nutritive value, domestic at present carry out the work of golden cuttlefish seed breeding.The Golden Crow
Crafty skin sticks to be slided, and high resilience is effective physical barriers of protection golden cuttlefish body, but golden cuttlefish breeds the skin of middle appearance
Ulcer disease, leads to the mortality of golden cuttlefish.In golden cuttlefish reproductive process, due to phenomenons such as shipping damages, frequently result in the Golden Crow
The damage of crafty skin, and then lead to golden cuttlefish bacterial infection, funguses, induce Disease of skin fester, ultimately result in golden cuttlefish dead.Institute
How effectively to prevent the Disease of skin fester of golden cuttlefish to be particularly important.
Chinese herbal medicine belongs to natural drug, in application and the research of China, has accumulated rich experience.Using Chinese herbal medicine
Preventing and treating golden cuttlefish Disease of skin fester is increasingly subject to attention and the favor of people, is increasingly widely accepted, is the work with its uniqueness
Inseparable with mechanism, model of action and advantage, put it briefly, herbal control disease has Accommodation, strengthening vital QI to eliminate pathogenic factors, no
Drug resistance and the incomparable feature of other medicines and the advantage such as nuisanceless, effect is good, and there is not antibiotic medicine
Residue problem, breeds products export to the Aquatic product of China highly beneficial.In addition, Chinese herbal medicine also has low price, wide material sources, make
Use the advantages of facilitate, be one of developing direction of fisheries drug from now on.
Content of the invention
It is an object of the invention to provide a kind of Chinese herbal and crude drugs preparationses for preventing and treating golden cuttlefish Disease of skin fester.
The object of the present invention is achieved like this：
A kind of Chinese herbal and crude drugs preparationses for preventing and treating golden cuttlefish Disease of skin fester, by the Chinese crude drug preparation of following weight portion
Become：Radix Isatidis 16-20 part, Fructus Gardeniae 16-20 part, Radix Sophorae Flavescentiss 12-18, Herba Andrographis 8-12 part, Fructus Gardeniae 12-18 part, Rhizoma Polygoni Cuspidati 12-18 part,
Radix Achyranthis Bidentatae 2-6 part, Herba crotalariae albidae 8-11 part, Galla Chinensiss 2-6 part, Radix Glycyrrhizae 8-20 part.
Preferably, the described Chinese herbal and crude drugs preparationses for preventing and treating golden cuttlefish Disease of skin fester, by the Chinese medicine of following weight portion
Material is prepared from：18 parts of Radix Isatidis, 18 parts of Fructus Gardeniae, Radix Sophorae Flavescentiss 16,10 parts of Herba Andrographis, 16 parts of Fructus Gardeniae, 14 parts of Rhizoma Polygoni Cuspidati, 4 parts of Radix Achyranthis Bidentatae, Huang
9 parts of Herba Violae of flower, 4 parts of Galla Chinensiss, 11 parts of Radix Glycyrrhizae.
It is further preferred that the described Chinese herbal and crude drugs preparationses for preventing and treating golden cuttlefish Disease of skin fester are granules.
The preparation method of the Chinese herbal and crude drugs preparationses that above-mentioned each Chinese crude drug preparation cost is invented, comprises the steps：
The first step, prepares clear paste powder：
1) get the raw materials ready：Weigh the above-mentioned Chinese crude drug cleaning up by recipe quantity, pulverize, standby；
2) decoct：Add water to cook, first decocts 8 times that every tank adds water as medical material total amount, keeps 2 hours, carry after ebuillition of heated
Take liquid to filter through 200 mesh filters and enter settling tank；Second decocts the water heating extraction adding 6 times of medical material amount, protects boiling 1.5 little
When, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitate：Extract liquid precipitate 12 hours in settling tank, extract supernatant and filter through 200 mesh filters and steam to triple effect
Send out in device, precipitate presses offal treatment；
4) concentrate：When supernatant is concentrated into relative density for 1.05～1.10 (40 DEG C of mensure) in triple effect evaporator,
Dilute clear cream 200 mesh filter is filtered in suction vacuum decompressioning and concentrating tank, adds ethanol to alcohol content 60% (v/v), place,
Filtration；Concentrating and mix to relative density is to go out cream when 1.10～1.22 (90 DEG C of mensure), to storage cream bucket, standby；
5) it is dried：Wherein vacuum：0.01MPa, temperature：78～82 DEG C, 12～18 hours drying times；
6) beat powder：Smashing fineness 80 mesh sieve, obtains clear paste powder；
Second step, according to clear paste powder：Starch：55% ethanol is 1：1～3：0.1～0.3 weight ratio weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, clear paste powder and starch is put in trough type mixing machine, stirs 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, is pelletized with 12 mesh stainless steel sifts, 60～70 DEG C of dryings 2 hours, takes out, cools and obtain final product described granule
Agent.
The consumption of above-mentioned preventing and treating golden cuttlefish Disease of skin fester Chinese medicine granules is to mix in the ratio of 60-80g/100kg body weight
Pharmaceutical chemistry, allows golden cuttlefish to be administered orally, and being used in conjunction 5-7 days is a course for the treatment of.
The present inventor prevents and treats golden cuttlefish Disease of skin fester with Chinese herbal and crude drugs preparationses, in terms of our experimental result, applies this
Bright Chinese herbal and crude drugs preparationses can effective control golden cuttlefish Disease of skin fester, the sickness rate of reduction golden cuttlefish Disease of skin fester and death
Rate, but also do not produce drug resistance.The present invention by Chinese medicine reasonable formula, anti-inflammation, enhancing immunity effect extremely
Significantly, it is that Aquatic product is bred industry and provided a kind of effectively treatment medicine of golden cuttlefish Disease of skin fester, there is instant effect, curative effect true
Reality, no drug residue, feature without any side effects；Its preparation method is simple, the needs of suitable large-scale production.
Specific embodiment
Further illustrate the present invention below by embodiment.Embodiments of the invention are only used for the present invention is described, and
It is not limitation of the present invention, under the concept thereof of the present invention, the present invention is broadly fallen into the simple modifications of preparation method of the present invention
Claimed scope.With reference to specific embodiment, technical scheme of the present invention is further described.
Embodiment 1
A kind of preventing and treating golden cuttlefish Disease of skin fester Chinese medicine granules, by Radix Isatidis, Fructus Gardeniae, Radix Sophorae Flavescentiss, Herba Andrographis, Fructus Gardeniae,
Rhizoma Polygoni Cuspidati, Radix Achyranthis Bidentatae, Herba crotalariae albidae, Galla Chinensiss, Radix Glycyrrhizae composition, wherein, Radix Isatidis 18kg, Fructus Gardeniae 18kg, Radix Sophorae Flavescentiss 16kg, Herba Andrographis
10kg, Fructus Gardeniae 16kg, Rhizoma Polygoni Cuspidati 14kg, Radix Achyranthis Bidentatae 4kg, Herba crotalariae albidae 9kg, Galla Chinensiss 4kg, Radix Glycyrrhizae 11kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating golden cuttlefish Disease of skin fester, concrete preparation process is as follows：
The first step, prepares clear paste powder：
1) get the raw materials ready：Weigh clear Radix Isatidis 18kg, Fructus Gardeniae 18kg, Radix Sophorae Flavescentiss 16kg, Herba Andrographis 10kg, Fructus Gardeniae 16kg, Rhizoma Polygoni Cuspidati
14kg, Radix Achyranthis Bidentatae 4kg, Herba crotalariae albidae 9kg, Galla Chinensiss 4kg, Radix Glycyrrhizae 11kg are raw material, and wash clean Chinese crude drug is pulverized, standby；
2) decoct：Add water to cook, first decocts 8 times that every tank adds water as medical material total amount, keeps 2 hours, carry after ebuillition of heated
Take liquid to filter through 200 mesh filters and enter settling tank；Second decocts the water heating extraction adding 6 times of medical material amount, protects boiling 1.5 little
When, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitate：Extract liquid precipitate 12 hours in settling tank, extract supernatant and filter through 200 mesh filters and steam to triple effect
Send out in device, precipitate presses offal treatment；
4) concentrate：When supernatant is concentrated into relative density for 1.05～1.10 (40 DEG C of mensure) in triple effect evaporator,
Dilute clear cream 200 mesh filter is filtered in suction vacuum decompressioning and concentrating tank, adds ethanol to alcohol content 60% (v/v), place,
Filtration；Concentrating and mix to relative density is to go out cream when 1.10～1.22 (90 DEG C of mensure), to storage cream bucket, standby；
5) it is dried：Wherein vacuum：0.01MPa, temperature：78～82 DEG C, 12～18 hours drying times；
6) beat powder：Smashing fineness 80 mesh sieve, obtains clear paste powder；
Second step, according to clear paste powder：Starch：55% ethanol is 1：1～3：0.1～0.3 weight ratio weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, clear paste powder and starch is put in trough type mixing machine, stirs 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, is pelletized with 12 mesh stainless steel sifts, 60～70 DEG C of dryings 2 hours, takes out, cools and obtain final product described granule
Agent.
Embodiment 2
A kind of preventing and treating golden cuttlefish Disease of skin fester Chinese medicine granules, by Radix Isatidis, Fructus Gardeniae, Radix Sophorae Flavescentiss, Herba Andrographis, Fructus Gardeniae,
Rhizoma Polygoni Cuspidati, Radix Achyranthis Bidentatae, Herba crotalariae albidae, Galla Chinensiss, Radix Glycyrrhizae composition, wherein, Radix Isatidis 19kg, Fructus Gardeniae 17kg, Radix Sophorae Flavescentiss 15kg, Herba Andrographis
9kg, Fructus Gardeniae 14kg, Rhizoma Polygoni Cuspidati 13kg, Radix Achyranthis Bidentatae 3kg, Herba crotalariae albidae 10kg, Galla Chinensiss 5kg, Radix Glycyrrhizae 13kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating golden cuttlefish Disease of skin fester, concrete preparation process is as follows：
The first step, prepares clear paste powder：
1) get the raw materials ready：Weigh Radix Isatidis 19kg, Fructus Gardeniae 17kg, Radix Sophorae Flavescentiss 15kg, Herba Andrographis 9kg, Fructus Gardeniae 14kg, Rhizoma Polygoni Cuspidati 13kg,
Radix Achyranthis Bidentatae 3kg, Herba crotalariae albidae 10kg, Galla Chinensiss 5kg, Radix Glycyrrhizae 13kg are raw material, and wash clean Chinese crude drug is pulverized, standby；
2) decoct：Add water to cook, first decocts 8 times that every tank adds water as medical material total amount, keeps 2 hours, carry after ebuillition of heated
Take liquid to filter through 200 mesh filters and enter settling tank；Second decocts the water heating extraction adding 6 times of medical material amount, protects boiling 1.5 little
When, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitate：Extract liquid precipitate 12 hours in settling tank, extract supernatant and filter through 200 mesh filters and steam to triple effect
Send out in device, precipitate presses offal treatment；
4) concentrate：When supernatant is concentrated into relative density for 1.05～1.10 (40 DEG C of mensure) in triple effect evaporator,
Dilute clear cream 200 mesh filter is filtered in suction vacuum decompressioning and concentrating tank, adds ethanol to alcohol content 60% (v/v), place,
Filtration；Concentrating and mix to relative density is to go out cream when 1.10～1.22 (90 DEG C of mensure), to storage cream bucket, standby；
5) it is dried：Wherein vacuum：0.01MPa, temperature：78～82 DEG C, 12～18 hours drying times；
6) beat powder：Smashing fineness 80 mesh sieve, obtains clear paste powder；
Second step, according to clear paste powder：Starch：55% ethanol is 1：1～3：0.1～0.3 weight ratio weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, clear paste powder and starch is put in trough type mixing machine, stirs 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, is pelletized with 12 mesh stainless steel sifts, 60～70 DEG C of dryings 2 hours, takes out, cools and obtain final product described granule
Agent.
Embodiment 3
A kind of preventing and treating golden cuttlefish Disease of skin fester Chinese medicine granules, by Radix Isatidis, Fructus Gardeniae, Radix Sophorae Flavescentiss, Herba Andrographis, Fructus Gardeniae,
Rhizoma Polygoni Cuspidati, Radix Achyranthis Bidentatae, Herba crotalariae albidae, Galla Chinensiss, Radix Glycyrrhizae composition, wherein, Radix Isatidis 20kg, Fructus Gardeniae 20kg, Radix Sophorae Flavescentiss 18kg, Herba Andrographis
12kg, Fructus Gardeniae 18kg, Rhizoma Polygoni Cuspidati 18kg, Radix Achyranthis Bidentatae 6kg, Herba crotalariae albidae 11kg, Galla Chinensiss 6kg, Radix Glycyrrhizae 15kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating golden cuttlefish Disease of skin fester, concrete preparation process is as follows：
The first step, prepares clear paste powder：
1) get the raw materials ready：Weigh Radix Isatidis 19kg, Fructus Gardeniae 17kg, Radix Sophorae Flavescentiss 15kg, Herba Andrographis 9kg, Fructus Gardeniae 14kg, Rhizoma Polygoni Cuspidati 13kg,
Radix Achyranthis Bidentatae 3kg, Herba crotalariae albidae 10kg, Galla Chinensiss 5kg, Radix Glycyrrhizae 15kg are raw material, and wash clean Chinese crude drug is pulverized, standby；
2) decoct：Add water to cook, first decocts 8 times that every tank adds water as medical material total amount, keeps 2 hours, carry after ebuillition of heated
Take liquid to filter through 200 mesh filters and enter settling tank；Second decocts the water heating extraction adding 6 times of medical material amount, protects boiling 1.5 little
When, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitate：Extract liquid precipitate 12 hours in settling tank, extract supernatant and filter through 200 mesh filters and steam to triple effect
Send out in device, precipitate presses offal treatment；
4) concentrate：When supernatant is concentrated into relative density for 1.05～1.10 (40 DEG C of mensure) in triple effect evaporator,
Dilute clear cream 200 mesh filter is filtered in suction vacuum decompressioning and concentrating tank, adds ethanol to alcohol content 60% (v/v), place,
Filtration；Concentrating and mix to relative density is to go out cream when 1.10～1.22 (90 DEG C of mensure), to storage cream bucket, standby；
5) it is dried：Wherein vacuum：0.01MPa, temperature：78～82 DEG C, 12～18 hours drying times；
6) beat powder：Smashing fineness 80 mesh sieve, obtains clear paste powder；
Second step, according to clear paste powder：Starch：55% ethanol is 1：1～3：0.1～0.3 weight ratio weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, clear paste powder and starch is put in trough type mixing machine, stirs 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, is pelletized with 12 mesh stainless steel sifts, 60～70 DEG C of dryings 2 hours, takes out, cools and obtain final product described granule
Agent.
Embodiment 4 clinical trial
The consumption of the Chinese medicine granules of above-mentioned preventing and treating golden cuttlefish Disease of skin fester is to mix medicine in the ratio of 60g/100kg body weight
Bait, is administered orally, and being used in conjunction 5 days is a course for the treatment of.Reach the purpose for the treatment of disease by intestinal absorption after oral.
On July 20th, 2016, the golden cuttlefish morbidity that Shandong Province Weihai City nursery is bred, clinical symptoms：Ill
Golden cuttlefish tentacle, trunk or skin of head fester, and necrosis comes off, and severe patient festers and is deep into Musclar layer.It is typical case after diagnosing
Ulcer disease.Then after using Chinese medicine granules treatment, medication 2 days described in the embodiment of the present invention 2, the state of an illness is clearly better, and body color becomes
Change substantially, mortality rate reduces by sky, after 7 days, mortality rate is 0, is almost recovered.
Inventor prevents and treats golden cuttlefish Disease of skin fester with Chinese herbal and crude drugs preparationses, in terms of our experimental result, no matter being prevention,
Or treat, evident in efficacy, but also do not produce drug resistance, through test of many times and small area popularization and application, achieve good
Effect, makes breeding field economic benefit significantly improve.
Claims (3)
1. a kind of Chinese herbal and crude drugs preparationses for preventing and treating golden cuttlefish Disease of skin fester it is characterised in that：Chinese medicine by following weight portion
Material is prepared from：Radix Isatidis 16-20 part, Fructus Gardeniae 16-20 part, Radix Sophorae Flavescentiss 12-18, Herba Andrographis 8-12 part, Fructus Gardeniae 12-18 part, Rhizoma Polygoni Cuspidati
12-18 part, Radix Achyranthis Bidentatae 2-6 part, Herba crotalariae albidae 8-11 part, Galla Chinensiss 2-6 part, Radix Glycyrrhizae 8-20 part.
2. the Chinese herbal and crude drugs preparationses for preventing and treating golden cuttlefish Disease of skin fester according to claim 1 it is characterised in that：By such as
The Chinese crude drug of lower weight portion is prepared from：18 parts of Radix Isatidis, 18 parts of Fructus Gardeniae, Radix Sophorae Flavescentiss 16,10 parts of Herba Andrographis, 16 parts of Fructus Gardeniae, Rhizoma Polygoni Cuspidati
14 parts, 4 parts of Radix Achyranthis Bidentatae, 9 parts of Herba crotalariae albidae, 4 parts of Galla Chinensiss, 11 parts of Radix Glycyrrhizae.
3. the Chinese herbal and crude drugs preparationses for preventing and treating golden cuttlefish Disease of skin fester according to claim 1 and 2 it is characterised in that：
It is granule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610875284.8A CN106377591A (en) | 2016-09-30 | 2016-09-30 | Chinese herbal medicine preparation for preventing and controlling sepia esculenta skin fester diseases |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610875284.8A CN106377591A (en) | 2016-09-30 | 2016-09-30 | Chinese herbal medicine preparation for preventing and controlling sepia esculenta skin fester diseases |
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| Publication Number | Publication Date |
|---|---|
| CN106377591A true CN106377591A (en) | 2017-02-08 |
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ID=57937212
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610875284.8A Pending CN106377591A (en) | 2016-09-30 | 2016-09-30 | Chinese herbal medicine preparation for preventing and controlling sepia esculenta skin fester diseases |
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| CN (1) | CN106377591A (en) |
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2016
- 2016-09-30 CN CN201610875284.8A patent/CN106377591A/en active Pending
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Application publication date: 20170208 |