CN106377591A - Chinese herbal medicine preparation for preventing and controlling sepia esculenta skin fester diseases - Google Patents
Chinese herbal medicine preparation for preventing and controlling sepia esculenta skin fester diseases Download PDFInfo
- Publication number
- CN106377591A CN106377591A CN201610875284.8A CN201610875284A CN106377591A CN 106377591 A CN106377591 A CN 106377591A CN 201610875284 A CN201610875284 A CN 201610875284A CN 106377591 A CN106377591 A CN 106377591A
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese herbal
- radix
- fructus gardeniae
- preventing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241001441745 Sepia esculenta Species 0.000 title claims abstract description 44
- 201000010099 disease Diseases 0.000 title claims abstract description 30
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract description 30
- 238000002360 preparation method Methods 0.000 title claims abstract description 30
- 241000411851 herbal medicine Species 0.000 title abstract description 10
- 241000746375 Andrographis Species 0.000 claims abstract description 14
- 239000003814 drug Substances 0.000 claims description 39
- 229940079593 drug Drugs 0.000 claims description 24
- 239000008187 granular material Substances 0.000 claims description 15
- 239000010231 banlangen Substances 0.000 claims description 13
- 239000000463 material Substances 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 13
- 230000008901 benefit Effects 0.000 abstract description 5
- 238000004659 sterilization and disinfection Methods 0.000 abstract 2
- 235000018142 Hedysarum alpinum var americanum Nutrition 0.000 abstract 1
- 240000006461 Hedysarum alpinum var. americanum Species 0.000 abstract 1
- 241000334160 Isatis Species 0.000 abstract 1
- 235000014220 Rhus chinensis Nutrition 0.000 abstract 1
- 240000003152 Rhus chinensis Species 0.000 abstract 1
- 241000292546 Taraxacum mongolicum Species 0.000 abstract 1
- 239000013043 chemical agent Substances 0.000 abstract 1
- 238000013329 compounding Methods 0.000 abstract 1
- 231100000614 poison Toxicity 0.000 abstract 1
- 230000007096 poisonous effect Effects 0.000 abstract 1
- 230000001954 sterilising effect Effects 0.000 abstract 1
- 230000004083 survival effect Effects 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 44
- 239000000843 powder Substances 0.000 description 24
- 230000000694 effects Effects 0.000 description 14
- 239000006071 cream Substances 0.000 description 12
- 239000002244 precipitate Substances 0.000 description 12
- 229920002472 Starch Polymers 0.000 description 8
- 238000001035 drying Methods 0.000 description 8
- 239000000284 extract Substances 0.000 description 8
- 239000007788 liquid Substances 0.000 description 8
- 239000012567 medical material Substances 0.000 description 8
- 235000019698 starch Nutrition 0.000 description 8
- 239000008107 starch Substances 0.000 description 8
- 238000003756 stirring Methods 0.000 description 8
- 239000006228 supernatant Substances 0.000 description 8
- 239000000203 mixture Substances 0.000 description 7
- 239000002994 raw material Substances 0.000 description 7
- 206010013786 Dry skin Diseases 0.000 description 4
- 238000009835 boiling Methods 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 239000012141 concentrate Substances 0.000 description 4
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- 238000001914 filtration Methods 0.000 description 4
- 239000012467 final product Substances 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 239000007779 soft material Substances 0.000 description 4
- 229910001220 stainless steel Inorganic materials 0.000 description 4
- 239000010935 stainless steel Substances 0.000 description 4
- 238000003860 storage Methods 0.000 description 4
- 206010059866 Drug resistance Diseases 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- -1 wherein Substances 0.000 description 3
- 241000238371 Sepiidae Species 0.000 description 2
- 208000025865 Ulcer Diseases 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 238000009395 breeding Methods 0.000 description 2
- 230000001488 breeding effect Effects 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 241000238366 Cephalopoda Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241000237852 Mollusca Species 0.000 description 1
- 241001502129 Mullus Species 0.000 description 1
- 241000238370 Sepia Species 0.000 description 1
- 241000472272 Sepiida Species 0.000 description 1
- 241000616933 Trichiurus haumela Species 0.000 description 1
- 230000004308 accommodation Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 239000003640 drug residue Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000031891 intestinal absorption Effects 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000027272 reproductive process Effects 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/744—Gardenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
- A61K36/195—Strobilanthes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Insects & Arthropods (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a Chinese herbal medicine preparation for preventing and controlling sepia esculenta skin fester diseases. The Chinese herbal medicine preparation is prepared from the following Chinese herbal medicines in parts by weight: 16 to 20 parts of isatis root, 16 to 20 parts of fructus gardeniae, 12 to 18 parts of radix sophorae flavescentis, 8 to 12 parts of herba andrographis, 12 to 18 parts of fructus gardeniae, 12 to 18 parts of rhizoma polygoni cuspidati, 2 to 6 parts of radix achyranthis bidentatae, 8 to 11 parts of taraxacum mongolicum, 2 to 6 parts of Chinese gall, and 8 to 20 parts of liquorice root. The Chinese herbal medicine preparation has the advantages that by utilizing the reasonable compounding of traditional Chinese herbal medicines, the sepia esculenta skin fester problem can be prevented and controlled by disinfection and sterilization; the remaining of poisonous and harmful chemical agent in pool water and sepia esculenta is avoided; through using the Chinese herbal medicine preparation provided by the invention, the sepia esculenta skin fester diseases can be effectively prevented and controlled, the survival rate and spawning rate of the sepia esculenta are increased, and the important significance is provided for the propagation of the sepia esculenta.
Description
Technical field
The invention belongs to fishery practical technique field, specifically, it is used for preventing and treating golden cuttlefish skin particularly to one kind and burst
Chinese herbal and crude drugs preparationses of rotten disease and preparation method thereof.
Background technology
Golden cuttlefish Sepia esculenta (Hoyle 1885) also known as cuttlefish, mullet, belong to Mollusca, Cephalopoda, sheath
Subclass, Sepiida, Sepiidae, Sepia, are distributed in Bohai and Yellow Seas, the East Sea, the South Sea, Japanese Science Society and the Philippines sea
Domain, is also the maximum sepiellae seu sepiae of economic worth in northern China marine site, once together with Carnis Pseudosciaenae, Carnis Pseudosciaenae, Trichiurus haumela and be referred to as China
One of traditional four big fishery, are important fished species.But since the eighties in 20th century, due to overfishing and marine environment
The many reasons such as destruction, its stock number substantially fails, and yield drastically declines, and current golden cuttlefish has disappeared in many marine sites.
Because golden cuttlefish has delicious meat, the feature that is of high nutritive value, domestic at present carry out the work of golden cuttlefish seed breeding.The Golden Crow
Crafty skin sticks to be slided, and high resilience is effective physical barriers of protection golden cuttlefish body, but golden cuttlefish breeds the skin of middle appearance
Ulcer disease, leads to the mortality of golden cuttlefish.In golden cuttlefish reproductive process, due to phenomenons such as shipping damages, frequently result in the Golden Crow
The damage of crafty skin, and then lead to golden cuttlefish bacterial infection, funguses, induce Disease of skin fester, ultimately result in golden cuttlefish dead.Institute
How effectively to prevent the Disease of skin fester of golden cuttlefish to be particularly important.
Chinese herbal medicine belongs to natural drug, in application and the research of China, has accumulated rich experience.Using Chinese herbal medicine
Preventing and treating golden cuttlefish Disease of skin fester is increasingly subject to attention and the favor of people, is increasingly widely accepted, is the work with its uniqueness
Inseparable with mechanism, model of action and advantage, put it briefly, herbal control disease has Accommodation, strengthening vital QI to eliminate pathogenic factors, no
Drug resistance and the incomparable feature of other medicines and the advantage such as nuisanceless, effect is good, and there is not antibiotic medicine
Residue problem, breeds products export to the Aquatic product of China highly beneficial.In addition, Chinese herbal medicine also has low price, wide material sources, make
Use the advantages of facilitate, be one of developing direction of fisheries drug from now on.
Content of the invention
It is an object of the invention to provide a kind of Chinese herbal and crude drugs preparationses for preventing and treating golden cuttlefish Disease of skin fester.
The object of the present invention is achieved like this：
A kind of Chinese herbal and crude drugs preparationses for preventing and treating golden cuttlefish Disease of skin fester, by the Chinese crude drug preparation of following weight portion
Become：Radix Isatidis 16-20 part, Fructus Gardeniae 16-20 part, Radix Sophorae Flavescentiss 12-18, Herba Andrographis 8-12 part, Fructus Gardeniae 12-18 part, Rhizoma Polygoni Cuspidati 12-18 part,
Radix Achyranthis Bidentatae 2-6 part, Herba crotalariae albidae 8-11 part, Galla Chinensiss 2-6 part, Radix Glycyrrhizae 8-20 part.
Preferably, the described Chinese herbal and crude drugs preparationses for preventing and treating golden cuttlefish Disease of skin fester, by the Chinese medicine of following weight portion
Material is prepared from：18 parts of Radix Isatidis, 18 parts of Fructus Gardeniae, Radix Sophorae Flavescentiss 16,10 parts of Herba Andrographis, 16 parts of Fructus Gardeniae, 14 parts of Rhizoma Polygoni Cuspidati, 4 parts of Radix Achyranthis Bidentatae, Huang
9 parts of Herba Violae of flower, 4 parts of Galla Chinensiss, 11 parts of Radix Glycyrrhizae.
It is further preferred that the described Chinese herbal and crude drugs preparationses for preventing and treating golden cuttlefish Disease of skin fester are granules.
The preparation method of the Chinese herbal and crude drugs preparationses that above-mentioned each Chinese crude drug preparation cost is invented, comprises the steps：
The first step, prepares clear paste powder：
1) get the raw materials ready：Weigh the above-mentioned Chinese crude drug cleaning up by recipe quantity, pulverize, standby；
2) decoct：Add water to cook, first decocts 8 times that every tank adds water as medical material total amount, keeps 2 hours, carry after ebuillition of heated
Take liquid to filter through 200 mesh filters and enter settling tank；Second decocts the water heating extraction adding 6 times of medical material amount, protects boiling 1.5 little
When, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitate：Extract liquid precipitate 12 hours in settling tank, extract supernatant and filter through 200 mesh filters and steam to triple effect
Send out in device, precipitate presses offal treatment；
4) concentrate：When supernatant is concentrated into relative density for 1.05～1.10 (40 DEG C of mensure) in triple effect evaporator,
Dilute clear cream 200 mesh filter is filtered in suction vacuum decompressioning and concentrating tank, adds ethanol to alcohol content 60% (v/v), place,
Filtration；Concentrating and mix to relative density is to go out cream when 1.10～1.22 (90 DEG C of mensure), to storage cream bucket, standby；
5) it is dried：Wherein vacuum：0.01MPa, temperature：78～82 DEG C, 12～18 hours drying times；
6) beat powder：Smashing fineness 80 mesh sieve, obtains clear paste powder；
Second step, according to clear paste powder：Starch：55% ethanol is 1：1～3：0.1～0.3 weight ratio weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, clear paste powder and starch is put in trough type mixing machine, stirs 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, is pelletized with 12 mesh stainless steel sifts, 60～70 DEG C of dryings 2 hours, takes out, cools and obtain final product described granule
Agent.
The consumption of above-mentioned preventing and treating golden cuttlefish Disease of skin fester Chinese medicine granules is to mix in the ratio of 60-80g/100kg body weight
Pharmaceutical chemistry, allows golden cuttlefish to be administered orally, and being used in conjunction 5-7 days is a course for the treatment of.
The present inventor prevents and treats golden cuttlefish Disease of skin fester with Chinese herbal and crude drugs preparationses, in terms of our experimental result, applies this
Bright Chinese herbal and crude drugs preparationses can effective control golden cuttlefish Disease of skin fester, the sickness rate of reduction golden cuttlefish Disease of skin fester and death
Rate, but also do not produce drug resistance.The present invention by Chinese medicine reasonable formula, anti-inflammation, enhancing immunity effect extremely
Significantly, it is that Aquatic product is bred industry and provided a kind of effectively treatment medicine of golden cuttlefish Disease of skin fester, there is instant effect, curative effect true
Reality, no drug residue, feature without any side effects；Its preparation method is simple, the needs of suitable large-scale production.
Specific embodiment
Further illustrate the present invention below by embodiment.Embodiments of the invention are only used for the present invention is described, and
It is not limitation of the present invention, under the concept thereof of the present invention, the present invention is broadly fallen into the simple modifications of preparation method of the present invention
Claimed scope.With reference to specific embodiment, technical scheme of the present invention is further described.
Embodiment 1
A kind of preventing and treating golden cuttlefish Disease of skin fester Chinese medicine granules, by Radix Isatidis, Fructus Gardeniae, Radix Sophorae Flavescentiss, Herba Andrographis, Fructus Gardeniae,
Rhizoma Polygoni Cuspidati, Radix Achyranthis Bidentatae, Herba crotalariae albidae, Galla Chinensiss, Radix Glycyrrhizae composition, wherein, Radix Isatidis 18kg, Fructus Gardeniae 18kg, Radix Sophorae Flavescentiss 16kg, Herba Andrographis
10kg, Fructus Gardeniae 16kg, Rhizoma Polygoni Cuspidati 14kg, Radix Achyranthis Bidentatae 4kg, Herba crotalariae albidae 9kg, Galla Chinensiss 4kg, Radix Glycyrrhizae 11kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating golden cuttlefish Disease of skin fester, concrete preparation process is as follows：
The first step, prepares clear paste powder：
1) get the raw materials ready：Weigh clear Radix Isatidis 18kg, Fructus Gardeniae 18kg, Radix Sophorae Flavescentiss 16kg, Herba Andrographis 10kg, Fructus Gardeniae 16kg, Rhizoma Polygoni Cuspidati
14kg, Radix Achyranthis Bidentatae 4kg, Herba crotalariae albidae 9kg, Galla Chinensiss 4kg, Radix Glycyrrhizae 11kg are raw material, and wash clean Chinese crude drug is pulverized, standby；
2) decoct：Add water to cook, first decocts 8 times that every tank adds water as medical material total amount, keeps 2 hours, carry after ebuillition of heated
Take liquid to filter through 200 mesh filters and enter settling tank；Second decocts the water heating extraction adding 6 times of medical material amount, protects boiling 1.5 little
When, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitate：Extract liquid precipitate 12 hours in settling tank, extract supernatant and filter through 200 mesh filters and steam to triple effect
Send out in device, precipitate presses offal treatment；
4) concentrate：When supernatant is concentrated into relative density for 1.05～1.10 (40 DEG C of mensure) in triple effect evaporator,
Dilute clear cream 200 mesh filter is filtered in suction vacuum decompressioning and concentrating tank, adds ethanol to alcohol content 60% (v/v), place,
Filtration；Concentrating and mix to relative density is to go out cream when 1.10～1.22 (90 DEG C of mensure), to storage cream bucket, standby；
5) it is dried：Wherein vacuum：0.01MPa, temperature：78～82 DEG C, 12～18 hours drying times；
6) beat powder：Smashing fineness 80 mesh sieve, obtains clear paste powder；
Second step, according to clear paste powder：Starch：55% ethanol is 1：1～3：0.1～0.3 weight ratio weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, clear paste powder and starch is put in trough type mixing machine, stirs 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, is pelletized with 12 mesh stainless steel sifts, 60～70 DEG C of dryings 2 hours, takes out, cools and obtain final product described granule
Agent.
Embodiment 2
A kind of preventing and treating golden cuttlefish Disease of skin fester Chinese medicine granules, by Radix Isatidis, Fructus Gardeniae, Radix Sophorae Flavescentiss, Herba Andrographis, Fructus Gardeniae,
Rhizoma Polygoni Cuspidati, Radix Achyranthis Bidentatae, Herba crotalariae albidae, Galla Chinensiss, Radix Glycyrrhizae composition, wherein, Radix Isatidis 19kg, Fructus Gardeniae 17kg, Radix Sophorae Flavescentiss 15kg, Herba Andrographis
9kg, Fructus Gardeniae 14kg, Rhizoma Polygoni Cuspidati 13kg, Radix Achyranthis Bidentatae 3kg, Herba crotalariae albidae 10kg, Galla Chinensiss 5kg, Radix Glycyrrhizae 13kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating golden cuttlefish Disease of skin fester, concrete preparation process is as follows：
The first step, prepares clear paste powder：
1) get the raw materials ready：Weigh Radix Isatidis 19kg, Fructus Gardeniae 17kg, Radix Sophorae Flavescentiss 15kg, Herba Andrographis 9kg, Fructus Gardeniae 14kg, Rhizoma Polygoni Cuspidati 13kg,
Radix Achyranthis Bidentatae 3kg, Herba crotalariae albidae 10kg, Galla Chinensiss 5kg, Radix Glycyrrhizae 13kg are raw material, and wash clean Chinese crude drug is pulverized, standby；
2) decoct：Add water to cook, first decocts 8 times that every tank adds water as medical material total amount, keeps 2 hours, carry after ebuillition of heated
Take liquid to filter through 200 mesh filters and enter settling tank；Second decocts the water heating extraction adding 6 times of medical material amount, protects boiling 1.5 little
When, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitate：Extract liquid precipitate 12 hours in settling tank, extract supernatant and filter through 200 mesh filters and steam to triple effect
Send out in device, precipitate presses offal treatment；
4) concentrate：When supernatant is concentrated into relative density for 1.05～1.10 (40 DEG C of mensure) in triple effect evaporator,
Dilute clear cream 200 mesh filter is filtered in suction vacuum decompressioning and concentrating tank, adds ethanol to alcohol content 60% (v/v), place,
Filtration；Concentrating and mix to relative density is to go out cream when 1.10～1.22 (90 DEG C of mensure), to storage cream bucket, standby；
5) it is dried：Wherein vacuum：0.01MPa, temperature：78～82 DEG C, 12～18 hours drying times；
6) beat powder：Smashing fineness 80 mesh sieve, obtains clear paste powder；
Second step, according to clear paste powder：Starch：55% ethanol is 1：1～3：0.1～0.3 weight ratio weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, clear paste powder and starch is put in trough type mixing machine, stirs 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, is pelletized with 12 mesh stainless steel sifts, 60～70 DEG C of dryings 2 hours, takes out, cools and obtain final product described granule
Agent.
Embodiment 3
A kind of preventing and treating golden cuttlefish Disease of skin fester Chinese medicine granules, by Radix Isatidis, Fructus Gardeniae, Radix Sophorae Flavescentiss, Herba Andrographis, Fructus Gardeniae,
Rhizoma Polygoni Cuspidati, Radix Achyranthis Bidentatae, Herba crotalariae albidae, Galla Chinensiss, Radix Glycyrrhizae composition, wherein, Radix Isatidis 20kg, Fructus Gardeniae 20kg, Radix Sophorae Flavescentiss 18kg, Herba Andrographis
12kg, Fructus Gardeniae 18kg, Rhizoma Polygoni Cuspidati 18kg, Radix Achyranthis Bidentatae 6kg, Herba crotalariae albidae 11kg, Galla Chinensiss 6kg, Radix Glycyrrhizae 15kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating golden cuttlefish Disease of skin fester, concrete preparation process is as follows：
The first step, prepares clear paste powder：
1) get the raw materials ready：Weigh Radix Isatidis 19kg, Fructus Gardeniae 17kg, Radix Sophorae Flavescentiss 15kg, Herba Andrographis 9kg, Fructus Gardeniae 14kg, Rhizoma Polygoni Cuspidati 13kg,
Radix Achyranthis Bidentatae 3kg, Herba crotalariae albidae 10kg, Galla Chinensiss 5kg, Radix Glycyrrhizae 15kg are raw material, and wash clean Chinese crude drug is pulverized, standby；
2) decoct：Add water to cook, first decocts 8 times that every tank adds water as medical material total amount, keeps 2 hours, carry after ebuillition of heated
Take liquid to filter through 200 mesh filters and enter settling tank；Second decocts the water heating extraction adding 6 times of medical material amount, protects boiling 1.5 little
When, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitate：Extract liquid precipitate 12 hours in settling tank, extract supernatant and filter through 200 mesh filters and steam to triple effect
Send out in device, precipitate presses offal treatment；
4) concentrate：When supernatant is concentrated into relative density for 1.05～1.10 (40 DEG C of mensure) in triple effect evaporator,
Dilute clear cream 200 mesh filter is filtered in suction vacuum decompressioning and concentrating tank, adds ethanol to alcohol content 60% (v/v), place,
Filtration；Concentrating and mix to relative density is to go out cream when 1.10～1.22 (90 DEG C of mensure), to storage cream bucket, standby；
5) it is dried：Wherein vacuum：0.01MPa, temperature：78～82 DEG C, 12～18 hours drying times；
6) beat powder：Smashing fineness 80 mesh sieve, obtains clear paste powder；
Second step, according to clear paste powder：Starch：55% ethanol is 1：1～3：0.1～0.3 weight ratio weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, clear paste powder and starch is put in trough type mixing machine, stirs 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, is pelletized with 12 mesh stainless steel sifts, 60～70 DEG C of dryings 2 hours, takes out, cools and obtain final product described granule
Agent.
Embodiment 4 clinical trial
The consumption of the Chinese medicine granules of above-mentioned preventing and treating golden cuttlefish Disease of skin fester is to mix medicine in the ratio of 60g/100kg body weight
Bait, is administered orally, and being used in conjunction 5 days is a course for the treatment of.Reach the purpose for the treatment of disease by intestinal absorption after oral.
On July 20th, 2016, the golden cuttlefish morbidity that Shandong Province Weihai City nursery is bred, clinical symptoms：Ill
Golden cuttlefish tentacle, trunk or skin of head fester, and necrosis comes off, and severe patient festers and is deep into Musclar layer.It is typical case after diagnosing
Ulcer disease.Then after using Chinese medicine granules treatment, medication 2 days described in the embodiment of the present invention 2, the state of an illness is clearly better, and body color becomes
Change substantially, mortality rate reduces by sky, after 7 days, mortality rate is 0, is almost recovered.
Inventor prevents and treats golden cuttlefish Disease of skin fester with Chinese herbal and crude drugs preparationses, in terms of our experimental result, no matter being prevention,
Or treat, evident in efficacy, but also do not produce drug resistance, through test of many times and small area popularization and application, achieve good
Effect, makes breeding field economic benefit significantly improve.
Claims (3)
1. a kind of Chinese herbal and crude drugs preparationses for preventing and treating golden cuttlefish Disease of skin fester it is characterised in that：Chinese medicine by following weight portion
Material is prepared from：Radix Isatidis 16-20 part, Fructus Gardeniae 16-20 part, Radix Sophorae Flavescentiss 12-18, Herba Andrographis 8-12 part, Fructus Gardeniae 12-18 part, Rhizoma Polygoni Cuspidati
12-18 part, Radix Achyranthis Bidentatae 2-6 part, Herba crotalariae albidae 8-11 part, Galla Chinensiss 2-6 part, Radix Glycyrrhizae 8-20 part.
2. the Chinese herbal and crude drugs preparationses for preventing and treating golden cuttlefish Disease of skin fester according to claim 1 it is characterised in that：By such as
The Chinese crude drug of lower weight portion is prepared from：18 parts of Radix Isatidis, 18 parts of Fructus Gardeniae, Radix Sophorae Flavescentiss 16,10 parts of Herba Andrographis, 16 parts of Fructus Gardeniae, Rhizoma Polygoni Cuspidati
14 parts, 4 parts of Radix Achyranthis Bidentatae, 9 parts of Herba crotalariae albidae, 4 parts of Galla Chinensiss, 11 parts of Radix Glycyrrhizae.
3. the Chinese herbal and crude drugs preparationses for preventing and treating golden cuttlefish Disease of skin fester according to claim 1 and 2 it is characterised in that：
It is granule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610875284.8A CN106377591A (en) | 2016-09-30 | 2016-09-30 | Chinese herbal medicine preparation for preventing and controlling sepia esculenta skin fester diseases |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610875284.8A CN106377591A (en) | 2016-09-30 | 2016-09-30 | Chinese herbal medicine preparation for preventing and controlling sepia esculenta skin fester diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106377591A true CN106377591A (en) | 2017-02-08 |
Family
ID=57937212
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610875284.8A Pending CN106377591A (en) | 2016-09-30 | 2016-09-30 | Chinese herbal medicine preparation for preventing and controlling sepia esculenta skin fester diseases |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106377591A (en) |
-
2016
- 2016-09-30 CN CN201610875284.8A patent/CN106377591A/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104971132B (en) | It is a kind of for preventing and treating the Chinese materia medica preparation of long octopus Disease of skin fester | |
| CN106377591A (en) | Chinese herbal medicine preparation for preventing and controlling sepia esculenta skin fester diseases | |
| CN106266145A (en) | A kind of Chinese herbal and crude drugs preparations for preventing and treating plant modification green grass or young crops willow clam Common Diseases | |
| CN106420966A (en) | Chinese herbal medicine preparation for preventing common diseases of pond-cultured Fenneropenaeus chinensiss | |
| CN106266146A (en) | A kind of Chinese herbal and crude drugs preparations for preventing and treating plant modification Concha Tridacna squamosa Common Diseases | |
| CN106265984A (en) | A kind of Chinese herbal and crude drugs preparations for preventing and treating pond culture Penaeus vannamei Common Diseases | |
| CN106334005A (en) | Chinese herbal medicine preparation for preventing skin fester of industrial culture sebastes schlegeli | |
| CN106266138A (en) | A kind of Chinese herbal and crude drugs preparations for preventing and treating industrialized culture left-eyed flounder Disease of skin fester | |
| CN106309639A (en) | Chinese herbal medicine preparation for preventing and treating skin fester disease of octopus vulgaris | |
| Chaolan et al. | Application of Chinese herbal medicine additives in aquaculture | |
| CN106309582A (en) | Chinese herbal medicine preparation for preventing and controlling common diseases of factory-like breeding chlamys farreri | |
| CN106309580A (en) | Chinese herbal medicine preparation for preventing and treating common diseases of pond-cultured portunus trituberculatus | |
| CN106389553A (en) | Chinese herbal medicine preparation for controlling common diseases of industrialized bred conches | |
| CN106334013A (en) | Chinese herbal medicine preparation for preventing skin fester of pond culture Takifugu flavidus | |
| CN106377601A (en) | Traditional Chinese herbal medicine preparation for preventing and treating skin ulceration of flatfish cultured in offshore cages | |
| CN106309668A (en) | Chinese herbal medicine preparation for preventing and controlling common diseases of factory-like breeding solen grandis | |
| CN106309597A (en) | Chinese herbal medicine preparation for preventing and controlling common diseases of factory-like breeding comb shell | |
| CN106334014A (en) | Chinese herbal medicine preparation for preventing skin fester of industrial cultureTakifugu flavidus | |
| CN106334016A (en) | Chinese herbal medicine preparation for preventing skin fester of octopus ocellatus | |
| CN106361873A (en) | Chinese herbal medicine preparation for preventing and controlling skin fester disease of black sea bream cultured in inshore net cage | |
| CN106361810A (en) | Chinese herbal medicine preparation for preventing and treating skin fester diseases of pseudosciaena crocea in industrial aquaculture | |
| CN106309640A (en) | Chinese herbal medicine preparation for preventing and treating common diseases of factory-bred argopecten irradians | |
| CN106421067A (en) | Chinese herbal medicine preparation for controlling common diseases of factory bred mercenaria | |
| CN106309667A (en) | Chinese herbal medicine preparation for preventing and controlling common diseases of pond cultured penaeus monodon | |
| CN106309641A (en) | Chinese herbal medicine preparation for preventing and treating skin fester disease of offshore cage-cultured takifugu flavidus |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20170208 |