CN106309668A - Chinese herbal medicine preparation for preventing and controlling common diseases of factory-like breeding solen grandis - Google Patents

Chinese herbal medicine preparation for preventing and controlling common diseases of factory-like breeding solen grandis Download PDF

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CN106309668A
CN106309668A CN201610962477.7A CN201610962477A CN106309668A CN 106309668 A CN106309668 A CN 106309668A CN 201610962477 A CN201610962477 A CN 201610962477A CN 106309668 A CN106309668 A CN 106309668A
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chinese herbal
breeding
common diseases
factory
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王培亮
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Weihai Hongrun Ocean Technology Co Ltd
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Weihai Hongrun Ocean Technology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/19—Acanthaceae (Acanthus family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/19—Acanthaceae (Acanthus family)
    • A61K36/195—Strobilanthes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A61K36/315—Isatis, e.g. Dyer's woad
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489—Sophora, e.g. necklacepod or mamani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/535—Perilla (beefsteak plant)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A61K36/744—Gardenia
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/756—Phellodendron, e.g. corktree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

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Abstract

The invention discloses a Chinese herbal medicine preparation for preventing and controlling common diseases of factory-like breeding solen grandis. The Chinese herbal medicine preparation comprises the following Chinese traditional medicines by weight part: 16-20 parts of isatis root, 16-20 parts of cape jasmine, 12-18 parts of radix sophorae flavescentis, 8-12 parts of common andrographis herb, 12-18 parts of moutan bark, 12-18 parts of purple perilla, 2-6 parts of radix achyranthis bidentatae, 8-11 parts of dandelion, 2-6 parts of golden cypress and 8-20 parts of liquorice. The traditional Chinese herbal medicines are reasonably combined; the problem of the common diseases of factory-like breeding solen grandis can be prevented by disinfecting and sterilizing; the Chinese herbal medicine preparation is adopted by the invention, so that the poisonous and harmful chemical agent is not remained in water pool or solen grandis body; the Chinese herbal medicine preparation can be used for effectively preventing and controlling the common diseases of factory-like breeding solen grandis, can increase the survival rate and spawning rate of the factory-like breeding solen grandis and has significance in breeding the factory-like breeding solen grandis.

Description

A kind of Chinese herbal and crude drugs preparations for preventing and treating plant modification razor shell Common Diseases
Technical field
The invention belongs to fishery practical technique field, specifically, be used for preventing and treating plant modification particularly to one big Chinese herbal and crude drugs preparations of Solen strictus Common Diseases and preparation method thereof.
Background technology
Razor shell (SolengrandisDunker) is subordinate to lamellibranchiata, different tooth subclass, curtain clam mesh, Solen strictus section, Solen strictus belong to, wide General it is distributed in coastal area of china various places, lives in Intertidal zone to the shallow sea of negative 20 meters of depth of waters.Razor shell individuality is relatively big, dressing percentage is high, Meat flavour is delicious and nutritious, be the embedded type shellfish of people's eating, good market prospect, economic worth are higher.Shell is long, reaches 14 centimetres, 4～5 times that a length of shell of general shell is high.Bright fracture edge is parallel with ventral margin, the most recessed in the middle part of ventral margin.Roof is positioned at Foremost, shell leading edge cuts shape, rear end circle to shell.Two shells are filled the span of a man's arms in thick bamboo tube shape, rear and front end opening.Chitin crisp fritter.Shell mass color is sliding, By yellowish-brown shell skin, sometimes there is pale red colored ribbon.Growth line is obvious, arranges along trailing edge and ventral margin direction.Shell inner face white or slightly Band purple, it is seen that pale red colored ribbon.Hinge is little, and two shells respectively have one piece of main tooth.Solen strictus approximates with razor shell, its main distinction Being that shell pole extends, 6～7 times that a length of shell of shell is high, shell is thin, and two shells are equal, and Carnis Sinonovacula is containing abundant protein, calcium, ferrum, selenium, dimension life The nutrients such as element A, flavour is delicious, is of high nutritive value, has the function of qi-restoratives.In sum, razor shell is a kind of high-quality High protein, low-fat food, it is of high nutritive value, delicious flavour, has good market prospect and value of exploiting and utilizing.
In recent years, China's Coastal Areas cultivated shellfish massive mortality event frequently occurs, and the shellfish kind related to is with foster Grow area and scope is continuously increased, make shellfishery suffer great economic loss.Cultivated shellfish massive mortality problem is Cause the extensive attention at aquaculture family.The cultivated shellfish bionosis cause of death, mainly has: virus, antibacterial, parasitic former Worm, rickettsia-like organism, class chlamydia, mycoplasma-like organism(MLO) etc..
Chinese herbal medicine belongs to natural drug, in application and the research of China, has accumulated rich experience.Utilize Chinese herbal medicine Preventing and treating plant modification razor shell Common Diseases, increasingly by attention and the favor of people, is increasingly widely accepted, is and it Unique mechanism of action, model of action and advantage are inseparable, put it briefly, and herbal control disease has Accommodation, holds up The most eliminating evil, have no drug resistance and feature that the other medicines such as nuisanceless are incomparable and advantage, effective, and there is not antibiosis The residue problem of element medicine, breeds products export to the Aquatic product of China highly beneficial.It addition, Chinese herbal medicine also has low price, come The advantages such as source is extensive, easy to use, are one of the developing direction of fish medicine from now on.
Summary of the invention
It is an object of the invention to provide a kind of Chinese herbal and crude drugs preparations for preventing and treating plant modification razor shell Common Diseases.
The object of the present invention is achieved like this:
A kind of Chinese herbal and crude drugs preparations for preventing and treating plant modification razor shell Common Diseases, by the Chinese crude drug of following weight portion It is prepared from: Radix Isatidis 16-20 part, Fructus Gardeniae 16-20 part, Radix Sophorae Flavescentis 12-18, Herba Andrographis 8-12 part, Cortex Moutan 12-18 part, Folium Perillae 12-18 part, Radix Achyranthis Bidentatae 2-6 part, Herba crotalariae albidae 8-11 part, Cortex Phellodendri 2-6 part, Radix Glycyrrhizae 8-20 part.
Preferably, the described Chinese herbal and crude drugs preparations for preventing and treating plant modification razor shell Common Diseases, by following weight Part Chinese crude drug be prepared from: Radix Isatidis 18 parts, Fructus Gardeniae 18 parts, Radix Sophorae Flavescentis 16, Herba Andrographis 10 parts, Cortex Moutan 16 parts, Folium Perillae 14 parts, Radix Achyranthis Bidentatae 4 parts, Herba crotalariae albidae 9 parts, Cortex Phellodendri 4 parts, 11 parts of Radix Glycyrrhizae.
It is further preferred that described is granule for preventing and treating the Chinese herbal and crude drugs preparations of plant modification razor shell Common Diseases Agent.
By the preparation method of the Chinese herbal and crude drugs preparations that above-mentioned each Chinese crude drug preparation cost is invented, comprise the steps:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh the above-mentioned Chinese crude drug cleaned up by recipe quantity, pulverize, standby；
2) decocting: boiling, first decocts every tank adds water 8 times into medical material total amount, keeps 2 hours, carry after ebuillition of heated Take liquid and filter entrance settling tank through 200 mesh filters；Second decocts the water heating extraction adding medical material amount 6 times, protects boiling 1.5 little Time, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitation: in settling tank, extracting solution precipitates 12 hours, extraction supernatant filters to triple effect steaming through 200 mesh filters Sending out in device, precipitate presses offal treatment；
4) concentrate: when supernatant be concentrated in triple effect evaporator relative density be 1.05～1.10 (40 DEG C of mensuration) time, By dilute clear paste in 200 mesh filters filter suction vacuum decompressioning and concentrating tank, addition ethanol, to alcohol content 60% (v/v), is placed, Filter；Concentrate and mix and go out cream when being 1.10～1.22 (90 DEG C of mensuration) to relative density, to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01MPa, temperature: 78～82 DEG C, drying time 12～18 hours；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, puts into clear paste powder in trough type mixing machine with starch, stirs 20 minutes, be slowly added into 55% while stirring Ethanol, to making soft material, pelletizes with 12 mesh stainless steel sifts, and 60～70 DEG C are dried 2 hours, take out, cool and i.e. obtain described granule Agent.
The consumption of above-mentioned preventing and treating plant modification razor shell Common Diseases Chinese medicine granules is by 60-80g/100kg body weight Ratio mix pharmaceutical chemistry, allow plant modification razor shell be administered orally, being used in conjunction 5-7 days is a course for the treatment of.
The present inventor prevents and treats plant modification razor shell Common Diseases with Chinese herbal and crude drugs preparations, in terms of our experimental result, The Chinese herbal and crude drugs preparations of the application present invention can effectively control plant modification razor shell Common Diseases, reduces plant modification razor shell The M & M of Common Diseases, but also do not produce drug resistance.The present invention, by Chinese medicine reasonable formula, antibacterial disappears Effect scorching, enhancing immunity is extremely notable, breeds industry for Aquatic product and provides a kind of plant modification razor shell Common Diseases Effectively medicine, have instant effect, curative effect really, no drug residue, feature without any side effects；Its preparation method is simple, It is suitable for the needs of large-scale production.
Detailed description of the invention
The present invention is further illustrated below by embodiment.Embodiments of the invention are only used for illustrating the present invention, and It not limitation of the present invention, under the concept thereof of the present invention, the simple modifications of preparation method of the present invention is broadly fallen into the present invention Claimed scope.Below in conjunction with specific embodiment, technical scheme of the present invention is further described.
Embodiment 1
A kind of Chinese medicine granules preventing and treating plant modification razor shell Common Diseases, by Radix Isatidis, Fructus Gardeniae, Radix Sophorae Flavescentis, punching Lotus, Cortex Moutan, Folium Perillae, Radix Achyranthis Bidentatae, Herba crotalariae albidae, Cortex Phellodendri, Radix Glycyrrhizae composition, wherein, Radix Isatidis 18kg, Fructus Gardeniae 18kg, Radix Sophorae Flavescentis 16kg, Herba Andrographis 10kg, Cortex Moutan 16kg, Folium Perillae 14kg, Radix Achyranthis Bidentatae 4kg, Herba crotalariae albidae 9kg, Cortex Phellodendri 4kg, Radix Glycyrrhizae 11kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating plant modification razor shell Common Diseases, concrete preparation process is such as Under:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh clear Radix Isatidis 18kg, Fructus Gardeniae 18kg, Radix Sophorae Flavescentis 16kg, Herba Andrographis 10kg, Cortex Moutan 16kg, Folium Perillae 14kg, Radix Achyranthis Bidentatae 4kg, Herba crotalariae albidae 9kg, Cortex Phellodendri 4kg, Radix Glycyrrhizae 11kg are raw material, wash clean Chinese crude drug, pulverize, standby；
2) decocting: boiling, first decocts every tank adds water 8 times into medical material total amount, keeps 2 hours, carry after ebuillition of heated Take liquid and filter entrance settling tank through 200 mesh filters；Second decocts the water heating extraction adding medical material amount 6 times, protects boiling 1.5 little Time, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitation: in settling tank, extracting solution precipitates 12 hours, extraction supernatant filters to triple effect steaming through 200 mesh filters Sending out in device, precipitate presses offal treatment；
4) concentrate: when supernatant be concentrated in triple effect evaporator relative density be 1.05～1.10 (40 DEG C of mensuration) time, By dilute clear paste in 200 mesh filters filter suction vacuum decompressioning and concentrating tank, addition ethanol, to alcohol content 60% (v/v), is placed, Filter；Concentrate and mix and go out cream when being 1.10～1.22 (90 DEG C of mensuration) to relative density, to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01MPa, temperature: 78～82 DEG C, drying time 12～18 hours；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, puts into clear paste powder in trough type mixing machine with starch, stirs 20 minutes, be slowly added into 55% while stirring Ethanol, to making soft material, pelletizes with 12 mesh stainless steel sifts, and 60～70 DEG C are dried 2 hours, take out, cool and i.e. obtain described granule Agent.
Embodiment 2
A kind of Chinese medicine granules preventing and treating plant modification razor shell Common Diseases, by Radix Isatidis, Fructus Gardeniae, Radix Sophorae Flavescentis, punching Lotus, Cortex Moutan, Folium Perillae, Radix Achyranthis Bidentatae, Herba crotalariae albidae, Cortex Phellodendri, Radix Glycyrrhizae composition, wherein, Radix Isatidis 19kg, Fructus Gardeniae 17kg, Radix Sophorae Flavescentis 15kg, Herba Andrographis 9kg, Cortex Moutan 14kg, Folium Perillae 13kg, Radix Achyranthis Bidentatae 3kg, Herba crotalariae albidae 10kg, Cortex Phellodendri 5kg, Radix Glycyrrhizae 13kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating plant modification razor shell Common Diseases, concrete preparation process is such as Under:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh Radix Isatidis 19kg, Fructus Gardeniae 17kg, Radix Sophorae Flavescentis 15kg, Herba Andrographis 9kg, Cortex Moutan 14kg, Folium Perillae 13kg, Radix Achyranthis Bidentatae 3kg, Herba crotalariae albidae 10kg, Cortex Phellodendri 5kg, Radix Glycyrrhizae 13kg are raw material, wash clean Chinese crude drug, pulverize, standby；
2) decocting: boiling, first decocts every tank adds water 8 times into medical material total amount, keeps 2 hours, carry after ebuillition of heated Take liquid and filter entrance settling tank through 200 mesh filters；Second decocts the water heating extraction adding medical material amount 6 times, protects boiling 1.5 little Time, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitation: in settling tank, extracting solution precipitates 12 hours, extraction supernatant filters to triple effect steaming through 200 mesh filters Sending out in device, precipitate presses offal treatment；
4) concentrate: when supernatant be concentrated in triple effect evaporator relative density be 1.05～1.10 (40 DEG C of mensuration) time, By dilute clear paste in 200 mesh filters filter suction vacuum decompressioning and concentrating tank, addition ethanol, to alcohol content 60% (v/v), is placed, Filter；Concentrate and mix and go out cream when being 1.10～1.22 (90 DEG C of mensuration) to relative density, to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01MPa, temperature: 78～82 DEG C, drying time 12～18 hours；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, puts into clear paste powder in trough type mixing machine with starch, stirs 20 minutes, be slowly added into 55% while stirring Ethanol, to making soft material, pelletizes with 12 mesh stainless steel sifts, and 60～70 DEG C are dried 2 hours, take out, cool and i.e. obtain described granule Agent.
Embodiment 3
A kind of Chinese medicine granules preventing and treating plant modification razor shell Common Diseases, by Radix Isatidis, Fructus Gardeniae, Radix Sophorae Flavescentis, punching Lotus, Cortex Moutan, Folium Perillae, Radix Achyranthis Bidentatae, Herba crotalariae albidae, Cortex Phellodendri, Radix Glycyrrhizae composition, wherein, Radix Isatidis 20kg, Fructus Gardeniae 20kg, Radix Sophorae Flavescentis 18kg, Herba Andrographis 12kg, Cortex Moutan 18kg, Folium Perillae 18kg, Radix Achyranthis Bidentatae 6kg, Herba crotalariae albidae 11kg, Cortex Phellodendri 6kg, Radix Glycyrrhizae 15kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating plant modification razor shell Common Diseases, concrete preparation process is such as Under:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh Radix Isatidis 19kg, Fructus Gardeniae 17kg, Radix Sophorae Flavescentis 15kg, Herba Andrographis 9kg, Cortex Moutan 14kg, Folium Perillae 13kg, Radix Achyranthis Bidentatae 3kg, Herba crotalariae albidae 10kg, Cortex Phellodendri 5kg, Radix Glycyrrhizae 15kg are raw material, wash clean Chinese crude drug, pulverize, standby；
2) decocting: boiling, first decocts every tank adds water 8 times into medical material total amount, keeps 2 hours, carry after ebuillition of heated Take liquid and filter entrance settling tank through 200 mesh filters；Second decocts the water heating extraction adding medical material amount 6 times, protects boiling 1.5 little Time, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitation: in settling tank, extracting solution precipitates 12 hours, extraction supernatant filters to triple effect steaming through 200 mesh filters Sending out in device, precipitate presses offal treatment；
4) concentrate: when supernatant be concentrated in triple effect evaporator relative density be 1.05～1.10 (40 DEG C of mensuration) time, By dilute clear paste in 200 mesh filters filter suction vacuum decompressioning and concentrating tank, addition ethanol, to alcohol content 60% (v/v), is placed, Filter；Concentrate and mix and go out cream when being 1.10～1.22 (90 DEG C of mensuration) to relative density, to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01MPa, temperature: 78～82 DEG C, drying time 12～18 hours；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, puts into clear paste powder in trough type mixing machine with starch, stirs 20 minutes, be slowly added into 55% while stirring Ethanol, to making soft material, pelletizes with 12 mesh stainless steel sifts, and 60～70 DEG C are dried 2 hours, take out, cool and i.e. obtain described granule Agent.
Embodiment 4 clinical trial
The consumption of the Chinese medicine granules of above-mentioned preventing and treating plant modification razor shell Common Diseases is by 60g/100kg body weight Ratio mixes pharmaceutical chemistry, and oral, being used in conjunction 5 days is a course for the treatment of.Reach to treat the purpose of disease by intestinal absorption after Kou Fu.
On July 20th, 2016, the plant modification razor shell morbidity that Weihai City, Shandong Province nursery is bred, clinical condition Shape: ill plant modification razor shell tentacle, trunk or skin of head fester, and necrosis comes off, and severe patient festers and is deep into Musclar layer.It is typical case's ulcer disease after diagnosing.Then with Chinese medicine granules treatment described in the embodiment of the present invention 2, after medication 2 days, the state of an illness Being clearly better, substantially, mortality rate reduces the change of health color by sky, and after 7 days, mortality rate is 0, is almost recovered.
Inventor prevents and treats plant modification razor shell Common Diseases with Chinese herbal and crude drugs preparations, in terms of our experimental result, no Pipe is prevention, or treatment, evident in efficacy, but also does not produce drug resistance, through test of many times and little area popularization and application, obtains Good effect, makes the breeding field economic benefit significantly improve.

Claims (3)

1. the Chinese herbal and crude drugs preparations being used for preventing and treating plant modification razor shell Common Diseases, it is characterised in that: by following weight The Chinese crude drug of part is prepared from: Radix Isatidis 16-20 part, Fructus Gardeniae 16-20 part, Radix Sophorae Flavescentis 12-18, Herba Andrographis 8-12 part, Cortex Moutan 12- 18 parts, Folium Perillae 12-18 part, Radix Achyranthis Bidentatae 2-6 part, Herba crotalariae albidae 8-11 part, Cortex Phellodendri 2-6 part, Radix Glycyrrhizae 8-20 part.
Chinese herbal and crude drugs preparations for preventing and treating plant modification razor shell Common Diseases the most according to claim 1, its feature It is: be prepared from by the Chinese crude drug of following weight portion: Radix Isatidis 18 parts, Fructus Gardeniae 18 parts, Radix Sophorae Flavescentis 16, Herba Andrographis 10 parts, Paeonia suffruticosa Skin 16 parts, Folium Perillae 14 parts, Radix Achyranthis Bidentatae 4 parts, Herba crotalariae albidae 9 parts, Cortex Phellodendri 4 parts, 11 parts of Radix Glycyrrhizae.
Chinese herbal and crude drugs preparations for preventing and treating plant modification razor shell Common Diseases the most according to claim 1 and 2, it is special Levy and be: it is granule.
CN201610962477.7A 2016-11-04 2016-11-04 Chinese herbal medicine preparation for preventing and controlling common diseases of factory-like breeding solen grandis Withdrawn CN106309668A (en)

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Application publication date: 20170111