CN106309667A - Chinese herbal medicine preparation for preventing and controlling common diseases of pond cultured penaeus monodon - Google Patents
Chinese herbal medicine preparation for preventing and controlling common diseases of pond cultured penaeus monodon Download PDFInfo
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- CN106309667A CN106309667A CN201610961732.6A CN201610961732A CN106309667A CN 106309667 A CN106309667 A CN 106309667A CN 201610961732 A CN201610961732 A CN 201610961732A CN 106309667 A CN106309667 A CN 106309667A
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- 241000238552 Penaeus monodon Species 0.000 title claims abstract description 35
- 201000010099 disease Diseases 0.000 title claims abstract description 35
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract description 35
- 238000002360 preparation method Methods 0.000 title claims abstract description 29
- 241000411851 herbal medicine Species 0.000 title abstract description 8
- 239000003814 drug Substances 0.000 claims abstract description 43
- 241000746375 Andrographis Species 0.000 claims abstract description 14
- 229940079593 drug Drugs 0.000 claims description 25
- 239000008187 granular material Substances 0.000 claims description 15
- 241000628997 Flos Species 0.000 claims description 13
- 230000000694 effects Effects 0.000 abstract description 17
- 239000003640 drug residue Substances 0.000 abstract description 3
- 230000036039 immunity Effects 0.000 abstract description 2
- 241000205585 Aquilegia canadensis Species 0.000 abstract 1
- 235000008658 Artemisia capillaris Nutrition 0.000 abstract 1
- 241000092668 Artemisia capillaris Species 0.000 abstract 1
- 241000218691 Cupressaceae Species 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 230000003260 anti-sepsis Effects 0.000 abstract 1
- 238000009360 aquaculture Methods 0.000 abstract 1
- 244000144974 aquaculture Species 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 229940126680 traditional chinese medicines Drugs 0.000 abstract 1
- 229940126672 traditional medicines Drugs 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 44
- 239000000843 powder Substances 0.000 description 24
- 241000238557 Decapoda Species 0.000 description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 229920002472 Starch Polymers 0.000 description 8
- 238000009835 boiling Methods 0.000 description 8
- 239000012141 concentrate Substances 0.000 description 8
- 239000006071 cream Substances 0.000 description 8
- 238000000605 extraction Methods 0.000 description 8
- 239000012567 medical material Substances 0.000 description 8
- 239000000203 mixture Substances 0.000 description 8
- 239000002244 precipitate Substances 0.000 description 8
- 235000019698 starch Nutrition 0.000 description 8
- 239000008107 starch Substances 0.000 description 8
- 238000003756 stirring Methods 0.000 description 8
- 239000006228 supernatant Substances 0.000 description 8
- 239000002994 raw material Substances 0.000 description 7
- 239000003795 chemical substances by application Substances 0.000 description 5
- 230000008901 benefit Effects 0.000 description 4
- 238000001035 drying Methods 0.000 description 4
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 238000001556 precipitation Methods 0.000 description 4
- 239000007779 soft material Substances 0.000 description 4
- 229910001220 stainless steel Inorganic materials 0.000 description 4
- 239000010935 stainless steel Substances 0.000 description 4
- 238000010025 steaming Methods 0.000 description 4
- 238000003860 storage Methods 0.000 description 4
- 241000251468 Actinopterygii Species 0.000 description 3
- 206010059866 Drug resistance Diseases 0.000 description 3
- 241000927735 Penaeus Species 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 229940088710 antibiotic agent Drugs 0.000 description 3
- 241000238421 Arthropoda Species 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 2
- 241000238550 Penaeidae Species 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 244000052616 bacterial pathogen Species 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 241000238424 Crustacea Species 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 241000530452 Litopenaeus Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000241034 Palaemon pugio Species 0.000 description 1
- 241000660245 Schistomysis spiritus Species 0.000 description 1
- 206010040943 Skin Ulcer Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 230000004308 accommodation Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000007954 hypoxia Effects 0.000 description 1
- 230000031891 intestinal absorption Effects 0.000 description 1
- 210000000629 knee joint Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
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- 235000008935 nutritious Nutrition 0.000 description 1
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- 239000007787 solid Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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Abstract
The invention discloses a Chinese herbal medicine preparation for preventing and controlling common diseases of pond cultured penaeus monodon. The Chinese herbal medicine preparation comprises the following Chinese traditional medicines by weight part: 12-22 parts of capillary artemisia, 16-20 parts of radix bupleuri, 12-18 parts of radix sophorae flavescentis, 8-12 parts of golden cypress, 12-18 parts of moutan bark, 12-18 parts of common andrographis herb, 2-6 parts of radix achyranthis bidentatae, 8-11 parts of honeysuckle and 2-6 parts of gallnut. The traditional Chinese medicines are reasonably combined; the antisepsis and anti-inflammation effects and the effect of boosting immunity are obvious; a medicine for effectively treating the common diseases of pond cultured penaeus monodon is supplied for aquaculture industry; the Chinese herbal medicine preparation has the characteristics of quick effectiveness, practical curative effect, no drug residue and no toxic or side effect; the Chinese herbal medicine preparation provided by the invention can be used for effectively controlling the common diseases of pond cultured penaeus monodon and reducing the morbidity and mortality of the common diseases.
Description
Technical field
The invention belongs to fishery practical technique field, specifically, be used for preventing and treating pond culture speckle joint particularly to one
Chinese herbal and crude drugs preparations of prawn Common Diseases and preparation method thereof.
Background technology
Penaeus monodon (Penaeus monodon) is commonly called as ghost shrimp, grass shrimp, flower shrimp, ring shrimp, speckle joint shrimp, cattle shape prawn, connection
Big Tiger Prawns is generally called in He Guo food and agricultural organization.Arthropoda (Arthropoda), hapalonychia guiding principle it is under the jurisdiction of on taxonomy
(Crustacea), Decapoda (Decapoda), branch gill suborder (Natantia), Penaeidae (Penaeidae), Penaeus
(Penaeus), Litopenaeus subgenus, be largest kind in Penaeus.Eurysalinity, the high temperature resistant and hypoxia of energy, low temperature is fitted
Stress is more weak.Resistance against diseases is stronger.Individual big, shell is thicker, and edible ratio is less than Chinese prawn, and delicious meat is nutritious.Body
Shell is more solid, stands and arrests with hands.After water, the dry endurance being exposed to air is very strong, can sell shrimp alive.
The Common Diseases of pond culture Penaeus monodon, the most all can occur, and treatment difficulty is big, prevents for this disease
Control the principle that must adhere to " putting prevention first, anti-overweighting is controlled ".If shrimp body surface festers, treat such disease and not only to kill
Pathogenic bacterium in water body, more important point is to kill the antibacterial at skin ulceration, takes orally in antibacterials purged body simultaneously
Pathogenic bacterium.
Present stage many employings western medicine antibiotics is treated, although aquatic medicine controls relatively strict, but western medicine antibiotics is indiscriminate
The most extremely serious by situation so that the treatment difficulty of pond culture Penaeus monodon strengthens, and drug residue problem is more and more heavier, feeding
Product safety problem causes serious threat.China's natural resources of Chinese medicinal materials enriches, by Chinese medicine is rationally screened and prescription, as
Preventing and treating pond culture Penaeus monodon Common Diseases is first-selected, will have very important production practices meaning.
Chinese herbal medicine belongs to natural drug, in application and the research of China, has accumulated rich experience.Utilize Chinese herbal medicine
Preventing and treating pond culture Penaeus monodon Common Diseases, increasingly by attention and the favor of people, is increasingly widely accepted, is and it
Unique mechanism of action, model of action and advantage are inseparable, put it briefly, and herbal control disease has Accommodation, holds up
The most eliminating evil, have no drug resistance and feature that the other medicines such as nuisanceless are incomparable and advantage, effective, and there is not antibiosis
The residue problem of element medicine, highly beneficial to the animal husbandry products export of China.It addition, Chinese herbal medicine also has low price, source
Extensively, the advantage such as easy to use, is one of the developing direction of fish medicine from now on.
Summary of the invention
It is an object of the invention to provide a kind of Chinese herbal and crude drugs preparations for preventing and treating pond culture Penaeus monodon Common Diseases.
The object of the present invention is achieved like this:
A kind of Chinese herbal and crude drugs preparations for preventing and treating pond culture Penaeus monodon Common Diseases, by the Chinese crude drug of following weight portion
It is prepared from: Herba Artemisiae Scopariae 16-22 part, Radix Bupleuri 16-20 part, Radix Sophorae Flavescentis 12-18, Cortex Phellodendri 8-12 part, Cortex Moutan 12-18 part, Herba Andrographis 12-
18 parts, Radix Achyranthis Bidentatae 2-6 part, Flos Lonicerae 8-11 part, Galla Chinensis 2-6 part.
Preferably, the described Chinese herbal and crude drugs preparations for preventing and treating pond culture Penaeus monodon Common Diseases, by following weight
The Chinese crude drug of part is prepared from: Herba Artemisiae Scopariae 18 parts, Radix Bupleuri 18 parts, Radix Sophorae Flavescentis 16, Cortex Phellodendri 10 parts, Cortex Moutan 16 parts, Herba Andrographis 14 parts, cattle
4 parts of knee joint, Flos Lonicerae 9 parts, Galla Chinensis 4 parts.
It is further preferred that described is granule for preventing and treating the Chinese herbal and crude drugs preparations of pond culture Penaeus monodon Common Diseases
Agent.
By the preparation method of the Chinese herbal and crude drugs preparations that above-mentioned each Chinese crude drug preparation cost is invented, comprise the steps:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh the above-mentioned Chinese crude drug cleaned up by recipe quantity, pulverize, standby；
2) decocting: boiling, first decocts every tank adds water 8 times into medical material total amount, keeps 2 hours, carry after ebuillition of heated
Take liquid and filter entrance settling tank through 200 mesh filters；Second decocts the water heating extraction adding medical material amount 6 times, protects boiling 1.5 little
Time, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitation: in settling tank, extracting solution precipitates 12 hours, extraction supernatant filters to triple effect steaming through 200 mesh filters
Sending out in device, precipitate presses offal treatment；
4) concentrate: when supernatant be concentrated in triple effect evaporator relative density be 1.05～1.10 (40 DEG C of mensuration) time,
By dilute clear paste in 200 mesh filters filter suction vacuum decompressioning and concentrating tank, addition ethanol, to alcohol content 60% (v/v), is placed,
Filter；Concentrate and mix and go out cream when being 1.10～1.22 (90 DEG C of mensuration) to relative density, to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01MPa, temperature: 78～82 DEG C, drying time 12～18 hours；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, puts into clear paste powder in trough type mixing machine with starch, stirs 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, pelletizes with 12 mesh stainless steel sifts, and 60～70 DEG C are dried 2 hours, take out, cool and i.e. obtain described granule
Agent.
The consumption of above-mentioned preventing and treating pond culture Penaeus monodon Common Diseases Chinese medicine granules is by 50-80g/100kg body weight
Ratio mix pharmaceutical chemistry, allow pond culture Penaeus monodon be administered orally, being used in conjunction 5-7 days is a course for the treatment of.
The present inventor prevents and treats pond culture Penaeus monodon Common Diseases with Chinese herbal and crude drugs preparations, in terms of our experimental result,
The Chinese herbal and crude drugs preparations of the application present invention can effectively control pond culture Penaeus monodon Common Diseases, reduces pond culture Penaeus monodon
The M & M of Common Diseases, but also do not produce drug resistance.The present invention, by Chinese medicine reasonable formula, antibacterial disappears
Effect scorching, enhancing immunity is extremely notable, provides a kind of pond culture Penaeus monodon Common Diseases for culture fishery
Effectively medicine, have instant effect, curative effect really, no drug residue, feature without any side effects；Its preparation method is simple,
It is suitable for the needs that large-scale industrial produces.
Detailed description of the invention
The present invention is further illustrated below by embodiment.Embodiments of the invention are only used for illustrating the present invention, and
It not limitation of the present invention, under the concept thereof of the present invention, the simple modifications of preparation method of the present invention is broadly fallen into the present invention
Claimed scope.Below in conjunction with specific embodiment, technical scheme of the present invention is further described.
Embodiment 1
A kind of Chinese medicine granules preventing and treating pond culture Penaeus monodon Common Diseases, by Herba Artemisiae Scopariae, Radix Bupleuri, Radix Sophorae Flavescentis, Cortex Phellodendri, male
Cortex Moutan, Herba Andrographis, Radix Achyranthis Bidentatae, Flos Lonicerae, Galla Chinensis composition, wherein, Herba Artemisiae Scopariae 18kg, Radix Bupleuri 18kg, Radix Sophorae Flavescentis 16kg, Cortex Phellodendri 10kg,
Cortex Moutan 16kg, Herba Andrographis 14kg, Radix Achyranthis Bidentatae 4kg, Flos Lonicerae 9kg, Galla Chinensis 4kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating pond culture Penaeus monodon Common Diseases, concrete preparation process is such as
Under:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh clear Herba Artemisiae Scopariae 18kg, Radix Bupleuri 18kg, Radix Sophorae Flavescentis 16kg, Cortex Phellodendri 10kg, Cortex Moutan 16kg, Herba Andrographis
14kg, Radix Achyranthis Bidentatae 4kg, Flos Lonicerae 9kg, Galla Chinensis 4kg are raw material, wash clean Chinese crude drug, pulverize, standby；
2) decocting: boiling, first decocts every tank adds water 8 times into medical material total amount, keeps 2 hours, carry after ebuillition of heated
Take liquid and filter entrance settling tank through 200 mesh filters；Second decocts the water heating extraction adding medical material amount 6 times, protects boiling 1.5 little
Time, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitation: in settling tank, extracting solution precipitates 12 hours, extraction supernatant filters to triple effect steaming through 200 mesh filters
Sending out in device, precipitate presses offal treatment；
4) concentrate: when supernatant be concentrated in triple effect evaporator relative density be 1.05～1.10 (40 DEG C of mensuration) time,
By dilute clear paste in 200 mesh filters filter suction vacuum decompressioning and concentrating tank, addition ethanol, to alcohol content 60% (v/v), is placed,
Filter；Concentrate and mix and go out cream when being 1.10～1.22 (90 DEG C of mensuration) to relative density, to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01MPa, temperature: 78～82 DEG C, drying time 12～18 hours；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, puts into clear paste powder in trough type mixing machine with starch, stirs 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, pelletizes with 12 mesh stainless steel sifts, and 60～70 DEG C are dried 2 hours, take out, cool and i.e. obtain described granule
Agent.
Embodiment 2
A kind of Chinese medicine granules preventing and treating pond culture Penaeus monodon Common Diseases, by Herba Artemisiae Scopariae, Radix Bupleuri, Radix Sophorae Flavescentis, Cortex Phellodendri, male
Cortex Moutan, Herba Andrographis, Radix Achyranthis Bidentatae, Flos Lonicerae, Galla Chinensis composition, wherein, Herba Artemisiae Scopariae 19kg, Radix Bupleuri 17kg, Radix Sophorae Flavescentis 15kg, Cortex Phellodendri 9kg, male
Cortex Moutan 14kg, Herba Andrographis 13kg, Radix Achyranthis Bidentatae 3kg, Flos Lonicerae 10kg, Galla Chinensis 5kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating pond culture Penaeus monodon Common Diseases, concrete preparation process is such as
Under:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh Herba Artemisiae Scopariae 19kg, Radix Bupleuri 17kg, Radix Sophorae Flavescentis 15kg, Cortex Phellodendri 9kg, Cortex Moutan 14kg, Herba Andrographis 13kg,
Radix Achyranthis Bidentatae 3kg, Flos Lonicerae 10kg, Galla Chinensis 5kg are raw material, wash clean Chinese crude drug, pulverize, standby；
2) decocting: boiling, first decocts every tank adds water 8 times into medical material total amount, keeps 2 hours, carry after ebuillition of heated
Take liquid and filter entrance settling tank through 200 mesh filters；Second decocts the water heating extraction adding medical material amount 6 times, protects boiling 1.5 little
Time, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitation: in settling tank, extracting solution precipitates 12 hours, extraction supernatant filters to triple effect steaming through 200 mesh filters
Sending out in device, precipitate presses offal treatment；
4) concentrate: when supernatant be concentrated in triple effect evaporator relative density be 1.05～1.10 (40 DEG C of mensuration) time,
By dilute clear paste in 200 mesh filters filter suction vacuum decompressioning and concentrating tank, addition ethanol, to alcohol content 60% (v/v), is placed,
Filter；Concentrate and mix and go out cream when being 1.10～1.22 (90 DEG C of mensuration) to relative density, to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01MPa, temperature: 78～82 DEG C, drying time 12～18 hours；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, puts into clear paste powder in trough type mixing machine with starch, stirs 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, pelletizes with 12 mesh stainless steel sifts, and 60～70 DEG C are dried 2 hours, take out, cool and i.e. obtain described granule
Agent.
Embodiment 3
A kind of Chinese medicine granules preventing and treating pond culture Penaeus monodon Common Diseases, by Herba Artemisiae Scopariae, Radix Bupleuri, Radix Sophorae Flavescentis, Cortex Phellodendri, male
Cortex Moutan, Herba Andrographis, Radix Achyranthis Bidentatae, Flos Lonicerae, Galla Chinensis composition, wherein, Herba Artemisiae Scopariae 20kg, Radix Bupleuri 20kg, Radix Sophorae Flavescentis 18kg, Cortex Phellodendri 12kg,
Cortex Moutan 18kg, Herba Andrographis 18kg, Radix Achyranthis Bidentatae 6kg, Flos Lonicerae 11kg, Galla Chinensis 6kg.
The preparation method of the Chinese medicine granules of above-mentioned preventing and treating pond culture Penaeus monodon Common Diseases, concrete preparation process is such as
Under:
The first step, prepares clear paste powder:
1) get the raw materials ready: weigh Herba Artemisiae Scopariae 19kg, Radix Bupleuri 17kg, Radix Sophorae Flavescentis 15kg, Cortex Phellodendri 9kg, Cortex Moutan 14kg, Herba Andrographis 13kg,
Radix Achyranthis Bidentatae 3kg, Flos Lonicerae 10kg, Galla Chinensis 5kg are raw material, wash clean Chinese crude drug, pulverize, standby；
2) decocting: boiling, first decocts every tank adds water 8 times into medical material total amount, keeps 2 hours, carry after ebuillition of heated
Take liquid and filter entrance settling tank through 200 mesh filters；Second decocts the water heating extraction adding medical material amount 6 times, protects boiling 1.5 little
Time, extracting solution filters through 200 mesh filters and enters settling tank；
3) precipitation: in settling tank, extracting solution precipitates 12 hours, extraction supernatant filters to triple effect steaming through 200 mesh filters
Sending out in device, precipitate presses offal treatment；
4) concentrate: when supernatant be concentrated in triple effect evaporator relative density be 1.05～1.10 (40 DEG C of mensuration) time,
By dilute clear paste in 200 mesh filters filter suction vacuum decompressioning and concentrating tank, addition ethanol, to alcohol content 60% (v/v), is placed,
Filter；Concentrate and mix and go out cream when being 1.10～1.22 (90 DEG C of mensuration) to relative density, to storage cream bucket, standby；
5) it is dried: wherein vacuum: 0.01MPa, temperature: 78～82 DEG C, drying time 12～18 hours；
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder；
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 weighs clear paste powder, paste
Essence and 55% ethanol, wherein 55% ethanol refers to the ethanol water that volumetric concentration is 55%；
3rd step, puts into clear paste powder in trough type mixing machine with starch, stirs 20 minutes, be slowly added into 55% while stirring
Ethanol, to making soft material, pelletizes with 12 mesh stainless steel sifts, and 60～70 DEG C are dried 2 hours, take out, cool and i.e. obtain described granule
Agent.
Embodiment 4 clinical trial
The consumption of the Chinese medicine granules of above-mentioned preventing and treating pond culture Penaeus monodon Common Diseases is by 60g/100kg body weight
Ratio mixes pharmaceutical chemistry, and oral, being used in conjunction 5 days is a course for the treatment of.Reach to treat the purpose of disease by intestinal absorption after Kou Fu.
On June 28th, 2013, the pond culture speckle that certain pond culture cultivating penaeus monodon family, area, Rongcheng, Shandong Province is raised
Joint prawn morbidity, clinical symptoms: ill pond culture Penaeus monodon fish tail shank, trunk or skin of head fester, downright bad
Coming off, severe patient festers and is deep into Musclar layer, and the sick fish kiss end having festers.It is typical case's ulcer disease after diagnosing.Then real by the present invention
Executing described in example 2 Chinese medicine granules treatment, after medication 2 days, the state of an illness is clearly better, and substantially, mortality rate drops the change of health color by sky
Low, after 5 days, mortality rate is 0, is almost recovered.
Inventor prevents and treats pond culture Penaeus monodon Common Diseases with Chinese herbal and crude drugs preparations, in terms of our experimental result, no
Pipe is prevention, or treatment, evident in efficacy, but also does not produce drug resistance, through test of many times and little area popularization and application, obtains
Good effect, makes the fishing ground economic benefit significantly improve.
Claims (3)
1. the Chinese herbal and crude drugs preparations being used for preventing and treating pond culture Penaeus monodon Common Diseases, it is characterised in that: by following weight
The Chinese crude drug of part is prepared from: Herba Artemisiae Scopariae 12-22 part, Radix Bupleuri 16-20 part, Radix Sophorae Flavescentis 12-18, Cortex Phellodendri 8-12 part, Cortex Moutan 12-18
Part, Herba Andrographis 12-18 part, Radix Achyranthis Bidentatae 2-6 part, Flos Lonicerae 8-11 part, Galla Chinensis 2-6 part.
Chinese herbal and crude drugs preparations for preventing and treating pond culture Penaeus monodon Common Diseases the most according to claim 1, its feature
It is: be prepared from by the Chinese crude drug of following weight portion: Herba Artemisiae Scopariae 18 parts, Radix Bupleuri 18 parts, Radix Sophorae Flavescentis 16, Cortex Phellodendri 10 parts, Cortex Moutan 16
Part, Herba Andrographis 14 parts, Radix Achyranthis Bidentatae 4 parts, Flos Lonicerae 9 parts, Galla Chinensis 4 parts.
Chinese herbal and crude drugs preparations for preventing and treating pond culture Penaeus monodon Common Diseases the most according to claim 1 and 2, it is special
Levy and be: it is granule.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610961732.6A CN106309667A (en) | 2016-11-04 | 2016-11-04 | Chinese herbal medicine preparation for preventing and controlling common diseases of pond cultured penaeus monodon |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610961732.6A CN106309667A (en) | 2016-11-04 | 2016-11-04 | Chinese herbal medicine preparation for preventing and controlling common diseases of pond cultured penaeus monodon |
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|---|---|---|---|
| CN201610961732.6A Withdrawn CN106309667A (en) | 2016-11-04 | 2016-11-04 | Chinese herbal medicine preparation for preventing and controlling common diseases of pond cultured penaeus monodon |
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| Country | Link |
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| CN (1) | CN106309667A (en) |
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2016
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Application publication date: 20170111 |